Rozprawy doktorskie na temat „PBD”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Sprawdź 50 najlepszych rozpraw doktorskich naukowych na temat „PBD”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Przeglądaj rozprawy doktorskie z różnych dziedzin i twórz odpowiednie bibliografie.
Smellie, Melissa. "Molecular and cellular pharmacology of rationally designed PBD dimers". Thesis, University of Portsmouth, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261402.
Pełny tekst źródłaBurger, A. M., Paul M. Loadman, D. E. Thurston, R. Schultz, H. H. Fiebig i Michael C. Bibby. "Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119)". Italian Society of Chemotherapy and the Italian Federation of Human and Animal Mycopathology, 2007. http://hdl.handle.net/10454/4571.
Pełny tekst źródłaThe pyrrolobenzodiazepine monomer DRH-417 is a member of the anthramycin group of anti-tumor antibiotics that bind covalently to the N2 of guanine within the minor groove of DNA. DRH-417 emerged from the EORTC-Drug Discovery Committee and NCI 60 cell line in vitro screening programs as a potent antiproliferative agent with differential sensitivity towards certain cancer types such as melanoma, breast and renal cell carcinoma (mean IC(50) = 3 nM). DRH-417 was therefore tested for in vivo activity. The maximum tolerated dose (MTD) was established as 0.5 mg/kg given i.p. Marked anti-tumor activity was seen in two human renal cell cancers, one breast cancer and a murine colon tumor model (p<0.01). A selective HPLC (LC/MS) analytical method was developed and plasma pharmacokinetics determined. At a dose of 0.5 mg kg(-1), the plasma AUC was 540 nM h (197.1 ng h ml(-1)) and the peak plasma concentration (171 nM [62.4 ng ml(-1)]) occurred at 30 min., reaching doses levels well above those needed for in vitro antiproliferative activity. Genomic profiling of in vivo sensitive tumors revealed that the latter have an activated insulin-like growth factor signaling pathway.
Chrisospathis, Aristomenis 1969. "A new approach in blade shape adjustment in PBD-14 design mode". Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8606.
Pełny tekst źródłaIncludes bibliographical references (leaves 68-70).
The purpose of this study is to develop a more efficient and robust algorithm for adjusting the blade shape as a part of a coupled lifting-surface design/analysis code for marine propulsors developed at MIT, known as PBD-14. The algorithm for adjusting the blade shape in the current version of PBD-14 works satisfactorily in most cases. However, with more complex schemes such as ducted propulsors and/or higher load distributions, the process has to be carefully monitored by the user and the blade surface can develop corrugations in the spanwise direction. A different approach investigated in this study is based on an idea of aligning the blade shape by tracing streamlines. In order to satisfy the kinematic boundary condition, the final blade shape has to exactly match the streamlines of the flow field in which the propeller blade operates. The algorithm that is developed traces streamlines by calculating the total velocity on a grid of points and then exactly fits the blade on this grid of points. Initial tests of this algorithm have demonstrated its robustness by producing accurate blade shapes both in uniform and in more complicated flow fields. Finally, propeller fabrication is investigated, and tolerance issues as well as propeller inspection methods, traditional and modem, are examined. A cost analysis is performed that investigates the economic impact of manufacturing an example propeller according to a certain tolerance system.
by Aristomenis Chrisospathis.
S.M.and Nav.E.
Hipps, Henry. "Developing a continuous emulsion PBD-Graft-SAN polymerization process: factors for morphology control". Thesis, Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/10973.
Pełny tekst źródłaGamom, Ngounou Ewo Roland Christian. "Déploiement d'applications parallèles sur une architecture distribuée matériellement reconfigurable". Thesis, Cergy-Pontoise, 2015. http://www.theses.fr/2015CERG0773/document.
Pełny tekst źródłaAmong the architectural targets that could be buid a system on chip (SoC), dynamically reconfigurable architectures (DRA) offer interesting potential for flexibility and dynamicity . However this potential is still difficult to use in massively parallel on chip applications. In our work we identified and analyzed the solutions currently proposed to use DRA and found their limitations including: the use of a particular technology or proprietary architecture, the lack of parallel applications consideration, the difficult scalability, the lack of a common language adopted by the community to use the flexibility of DRA ...In our work we propose a solution for deployment on an DRA of a parallel application using standard SoC design flows. This solution is called MATIP ( textit {MPI Application Platform Task Integreation}) and uses primitives of MPI standard Version 2 to make communications and to reconfigure the MP-RSoC architecture . MATIP is a Platform-Based Design (PBD) level solution.The MATIP platform is modeled in three layers: interconnection, communication and application. Each layer is designed to satisfies the requirements of heterogeneity and dynamicity of parallel applications. For this, MATIP uses a distributed memory architecture and utilizes the message passing parallel programming paradigm to enhance scalability of the platform.MATIP frees the designer of all the details related to interconnection, communication between tasks and management of dynamic reconfiguration of the hardware target. A demonstrator of MATIP was performed on Xilinx FPGA through the implementation of an application consisting of two static and two dynamic hardware tasks. MATIP offers a bandwidth of 2.4 Gb / s and latency of 3.43 microseconds for the transfer of a byte. Compared to other MPI platforms (TMD-MPI, SOC-MPI MPI HAL), MATIP is in the state of the art
Kaliszczak, Maciej. "Rational design of pyrrolobenzodiazepine derivatives". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4923.
Pełny tekst źródłaHai, Bin. "Development and Implementation of New In Situ Techniques for the Study of Interfacial Phenomena". Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1259695728.
Pełny tekst źródłaHawkins, Rachel Marina. "Design, synthesis and biological evaluation of novel PBD-heterocycle and conjugates as potential transcription factor binding inhibitors". Thesis, University College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498774.
Pełny tekst źródłaLobo, Junior Marco Aurélio. "Design para a competitividade no Brasil: o caso do Projeto Design Export". reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/23983.
Pełny tekst źródłaSubmitted by Raquel Almeida (raquel.df13@gmail.com) on 2017-07-10T20:58:23Z No. of bitstreams: 1 2017_MarcoAurélioLoboJunior.pdf: 2897522 bytes, checksum: a5317ddbbd7608a6c09f80a610a74df4 (MD5)
Approved for entry into archive by Raquel Viana (raquelviana@bce.unb.br) on 2017-07-31T21:42:52Z (GMT) No. of bitstreams: 1 2017_MarcoAurélioLoboJunior.pdf: 2897522 bytes, checksum: a5317ddbbd7608a6c09f80a610a74df4 (MD5)
Made available in DSpace on 2017-07-31T21:42:52Z (GMT). No. of bitstreams: 1 2017_MarcoAurélioLoboJunior.pdf: 2897522 bytes, checksum: a5317ddbbd7608a6c09f80a610a74df4 (MD5) Previous issue date: 2017-07-31
O objetivo deste trabalho foi analisar o design para a competitividade internacional de produtos brasileiros, tendo como estudo de caso o Projeto Design Export, da Agência Brasileira de Promoção das Exportações e Investimentos (Apex-Brasil). Desde o início do século XXI percebe-se que o preço competitivo e a alta qualidade do produto não são mais as garantias para manter e conquistar mercados. Destaca-se as contribuições do design para enfrentar esses novos desafios no desenvolvimento de elementos e características que identificam e diferenciam os produtos e serviços das empresas em relação aos seus competidores, tanto no mercado nacional quanto no internacional. Para isso, foi necessário pesquisar: a história recente da competitividade internacional brasileira; o Programa Brasileiro do Design (PBD) e seus resultados e consequências no setor industrial; os principais programas de apoio ao design para o aumento da competitividade, em outros países; e o papel da Apex-Brasil, na inserção do design para o aumento das exportações brasileiras, por meio dos resultados do Projeto Design Export. O trabalho em parceria dos atores envolvidos – designers, empresários, associações setoriais e gestores – esteve diretamente relacionado ao sucesso do processo de gestão do projeto, que proporcionou melhores condições de competição para as empresas exportadoras, pois demonstrou e revelou a importância da utilização do design no processo de desenvolvimento de novos produtos, novas embalagens, novas marcas e novos serviços. Foram 610 empresas brasileiras sensibilizadas para o design, com 144 empresas visitadas e 114 empresas diagnosticadas quanto ao uso do design. Foram contratados 50 escritórios de design, que desenvolveram 108 projetos, em 60 cidades de 7 estados brasileiros. A experiência direta contribuiu para criar uma cultura de inovação entre as empresas brasileiras envolvidas, o que poderá resultar no aumento da excelência da produção industrial brasileira com vistas à exportação e no fomento ao mercado profissional de design e áreas afins.
The aim of the present study is to analyze the role of design in the international competitiveness of Brazilian products, through a case study from the Design Export Project from the Brazilian Trade and Investment Promotion Agency (Apex-Brasil). In the beginning of the 21st century, competitive prices and higher quality of a product were not guarantees of conquering and keeping international markets. Thus, the contributions of design in the development of elements and characteristics must be noted, as they serve to identify and distinguish the companies’ products and services from their competitors. In this context, the first step was the research of four mains issues: the recent story of the Brazilian international competitiveness; the Brazilian Design Program, its results and consequences in the industrial sector; the most important design support programs to improve competitiveness abroad; and the role of the Brazilian Trade and Investment Promotion Agency in the insertion of design in the development of Brazilian exports through the Design Export Project. The partnership between designers, entrepreneurs, trade associations and project managers was directly related with the success of the Project administration, which supplied better competitive conditions to the involved export companies. In such way, the project showed and revealed the importance of using design in the development process of new products, packages, brands and services. Out of 610 companies that were made aware of the importance of design, 144 companies were visited and 144 companies were alerted to the importance of the proper use of design. 50 design agencies were hired, developing 108 projects in 60 cities of 7 Brazilian states. Such direct experience contributed to the creation of a culture of innovation within the companies involved. This culture will possibly result in an increase of the excellence of Brazilian industrial export production, and in the stimulation of the market of design and its related areas.
Thompson, Thaddeus. "Rheological Study of Linear and Nonlinear Viscoelastic Behavior for Silica-Reinforced Polybutadiene and Polystyrene". University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1134566032.
Pełny tekst źródłaGONZALEZ, GONZALEZ JUVENAL 629192, i GONZALEZ JUVENAL GONZALEZ. "Detección de éter etílico en mezcla con etanol empleando compuestos poliméricos a base de polivinilpirrolidona (pvp), polibutadieno (pbd) y negro de carbono". Tesis de maestría, Universidad Autónoma del Estado de México, 2016. http://hdl.handle.net/20.500.11799/66101.
Pełny tekst źródłaGONZALEZ, GONZALEZ JUVENAL 629192, i GONZALEZ JUVENAL GONZALEZ. "Detección de éter etílico en mezcla con etanol empleando compuestos poliméricos a base de Polivinilpirrolidona (PVP), Polibutadieno (PBD) y Negro de Carbono". Tesis de maestría, UAEM, 2016. http://hdl.handle.net/20.500.11799/66120.
Pełny tekst źródłaStenlund, Anna, Sanna Sjöström i Cecilia Wännberg. "PRIVACY BY DESIGN likheter och skillnader mellan leverantörer och betällare : En studie med fokus på inställning, kunskap och utmaningar". Thesis, Umeå universitet, Institutionen för informatik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-148135.
Pełny tekst źródłaSaell, Franziska. "Female and male audiences' perception on a plant-based (Vegan) diet after having viewed the documentary film What the Health : How perception on a plant-based diet (Vegan) changes after having watched the documentary film What the Health". Thesis, Högskolan för lärande och kommunikation, Jönköping University, HLK, Medie- och kommunikationsvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48296.
Pełny tekst źródłaErrami, Jalal. "Modelling DNA Hairpins". Lyon, École normale supérieure (sciences), 2007. http://www.theses.fr/2007ENSL0403.
Pełny tekst źródłaDNA beacons are made of short single strands of DNA with terminal regions consisting of complementary base sequences. As a result, the two end-regions can self-assemble in a short DNA double helix, called the stem, while the remaining central part of the strand makes a loop. In this closed configuration, the single strand has the shape of a hairpin. Such hairpin conformations are important in determining the secondary structure of long single strands of DNA or RNA. In this thesis, we have developed two different models in order to study the thermodynamics and the kinetics of such systems. The first one is a planar square lattice model inspired by the lattice models which have been used to study protein folding. The second one includes the physical ingredients of the lattice model but without the constraint of the lattice. It combines polymer theory and the Peyrard-Bishop and Dauxois (PBD) model of DNA melting. With this approach we can compare our results quantitatively with the experimental ones
Maxwell, Megan Amanda, i n/a. "PEX1 Mutations in Australasian Patients with Disorders of Peroxisome Biogenesis". Griffith University. School of Biomolecular and Biomedical Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040219.100649.
Pełny tekst źródłaMaxwell, Megan Amanda. "PEX1 Mutations in Australasian Patients with Disorders of Peroxisome Biogenesis". Thesis, Griffith University, 2004. http://hdl.handle.net/10072/366184.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Jarrett, John M. "Synthesis and In-Vitro Cell Viability/Cytotoxicity Studies of Novel Pyrrolobenzodiazepine Derivatives". Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/honors/361.
Pełny tekst źródłaSöderström, Gunilla. "On the combustion and photolytic degradation products of some brominated flame retardants". Doctoral thesis, Umeå University, Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-107.
Pełny tekst źródłaMany modern products, especially electronic goods, are protected by brominated flame retardants (BFR). Some of the most common flame retardants are polybrominated diphenylethers (PBDE), tetrabromobisphenol-A (TBBP-A) and hexabromocyclododecane (HBCD). These compounds have been found in environmental samples and shown to have physiological effects on experimental animals. This thesis considers end-of-life aspects of brominated flame retardants. When spread in the environment, these compounds may be degraded into other forms. For example, if sludge contaminated with PBDE is used as an agricultural fertilizer, the PBDE could be degraded by sunlight to species of PBDE with lower degree of bromination and, to some extent, also form polybrominated dibenzofurans (PBDF). In addition, PBDF and polybrominated dibenzo-p-dioxins (PBDD) are formed during combustion of brominated flame retardants. When waste products with brominated flame retardants are co-combusted with household waste or other chlorinated fuel, polybrominated- chlorinated dibenzo-p-dioxins (PBCDD) and polybrominated- chlorinated dibenzofurans (PBCDF)will be formed. The bromin/chlorine composition of dioxins and furans is dependent on the bromine/chlorine ratio in the fuel, but the types of brominated flame retardants that are being combusted is less important. In the studies reported here, bromine levels higher than "normal" for household waste has been used. The results show that there is a pronounced increase in total dioxin levels in fluegas when when bromine is present, implying that waste containing brominated flame retardants should only be incinerated at combustion plants with effecient air pollution control devices.
Mingle, David. "Synthesis, Characterization and Biological Evaluation of Novel (S,E)-11-[2-(Arylmethylene) Hydrazono] Pyrrolo [2,1-c] [1,4] Benzodiazepine Derivatives". Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etd/3596.
Pełny tekst źródłaWilkinson, Gary P. "Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303". Thesis, University of Bradford, 2004. http://hdl.handle.net/10454/12542.
Pełny tekst źródłaFollet-Houttemane, Claudine. "Les Phases oxyfluorées du système BiO-Pbo-PbF stabilité-propriétés électriques, caractéristiques structurales /". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376051434.
Pełny tekst źródłaMagnusson, Wilhelm. "The EU General Data Protection Regulations and their consequences on computer system design". Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-213025.
Pełny tekst źródłaVid framställningen av denna avhandling är det mindre än ett år innan EUs nya dataskyddsförordning (GDPR) träder i kraft. Många har bristande förståelse av de nya förordningarna och rykten av varierande korrekthet cirkulerar inom IT industrin. Denna avhandling utför en kritisk undersökning utav de delar inom GDPR som berör system design och arkitektur och beskriver dess innebörd för system design. De nya lagarna jämförs med de föregående dataskyddslagarna (Direktiv 95/46/EC) för att påvisa de modifikationer som kommer krävas för att anpassa datorsystem till de nya förordningarna. Genom att undersöka de äldre dataskyddslagarnas effekt på industrin görs även förutsägelser kring hur GDPR kommer påverka IT industrin inom den närmaste framtiden. Än av de intressantare frågorna är vilka metoder som finns tillgängliga för att underlätta systemanpassningar relaterade till dataskyddsförordningar. Denna avhandling syftar att identifiera de mest etablerade av dessa typer av processer och jämföra deras lämplighet i förhållande till GDPR.
Wilkinson, Gary Paul. "Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents : pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303". Thesis, University of Bradford, 2004. http://hdl.handle.net/10454/12542.
Pełny tekst źródłaEllis, Cameron B. "Tribopairs in Wellbore Drilling: A Study of PCD Tilting Pad Bearings in an Electric Submersible Pump". BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7233.
Pełny tekst źródłaRenner, Annelies. "Mise au point de tests "preuve de principe" pour l'étude des inhibiteurs de la Plk1 et caractérisation de la Plk1 en tant que cible dans le traitement des leucémies aigües myéloïdes". Toulouse 3, 2008. http://thesesups.ups-tlse.fr/430/.
Pełny tekst źródłaPolo-like kinase 1, a major regulator of mitosis, is found overexpressed in many cancers and its overexpression correlates with a bad prognosis. Experimentally, the constitutive expression of Plk1 induces transformation of NIH3T3 cells and confer them the ability to initiate new tumours in athymic mice. In addition, Plk1 depletion in cancer cells induces apoptosis, suggesting that Plk1 may be a new pharmacological target in anticancer therapies. The first aim of my thesis was to generate molecular and cellular tools in order to characterize the activity of Plk1 inhibitors, evaluate the implication of Plk1 in different steps of cell division and to find new partners Plk1. We generated inducible cell lines allowing the expression of wild type and mutants' forms (inactivated, overactivated) of Plk1, and the analysis of their impact on growth, proliferation, cell cycle and also on known substrates of Plk1. As expected, the higher the activity of Plk1 is, the best its impact on these biological processes. We have tested on these inducible cell lines several inhibitors of Plk1, and developed an assay allowing a rapid and highly efficient evaluation of the effect of these inhibitors on the Plk1 pathway. The Luminex methodology was used on cell extracts in order to assess the activity of Plk1 on its downstream effectors. This methodology appears to be very efficient to analyse the effects of putative Plk1 inhibitors in cellulo. The second aim of my thesis was to analyse the status and role of Plk1 in a malignant hemopathy, Acute Myeloid Leukemia (AML). AML is a clonal hemopathy characterized by a block in differentiation and by an uncontrolled proliferation of immature leukemic cells. Molecular mechanisms involved in the dysregulation of cell cycle in AML are still poorly understood. We have characterized the expression and the role of Plk1 in AML cell lines and primary cells and analysed the consequences of a specific Plk1 inhibition in this pathology. .
Löfstrand, Karin. "Trends and exposure of naturally produced brominated substances in Baltic biota - with focus on OH-PBDEs, MeO-PBDEs and PBDDs". Doctoral thesis, Stockholms universitet, Institutionen för material- och miljökemi (MMK), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54421.
Pełny tekst źródłaAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: In press. Paper 4: Manuscript.
Andersson, Carl, i John Pettersson. "Behovet av ökad kontroll i stålbyggnadskonstruktioner". Thesis, Linnéuniversitetet, Institutionen för byggteknik (BY), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-85778.
Pełny tekst źródłaIn the work the need of increased inspections of steel structures with respect to errors of execution was examined. On 1 June 1994, the Swedish parliament decided to change the Planning and Building Act (PBL) and the changes came into force in 1995, where the entire responsibility for the construction and control of a building was placed on the developer. After the winters of 2009/10 and 2010/11, when several roofs collapsed by the snow weight, a number of design and execution faults were discovered. During the thesis work it was investigated what happens to the safety of building structures in steel that undergo changes during its lifetime and a comparison with current regulations was made. A field study and several interviews were conducted where the focus was on execution errors and how changes in regulations led to today's self-control systems that affect the number of execution errors. The results of the work show that there may be a need to review the current control system and that the number of serious execution errors in the case study object increased after 1995.
Gonzalez, Walter G. "Protein-Ligand Interactions and Allosteric Regulation of Activity in DREAM Protein". FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2503.
Pełny tekst źródłaKhan, Simeen. "Colloidal PbS and PbS/CdS Core/Shell Nanosheets". Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1447955111.
Pełny tekst źródłaFlayhan, Ali. "Reconnaissance phage-bactérie dans le système phage T5 - E. Coli : Caractérisation biochimique et structurale du complexe FhuA-pb5 et de la protéine caudale pb9". Paris 7, 2012. http://www.theses.fr/2012PA077164.
Pełny tekst źródłaThis thesis approached the first step of infection in the System E. Coli - phage T5. My research has focused on the characterization of the complex formed between pb5, the receptor binding protein (RBP) of T5 and its receptor FhuA, on the surface of E. Coli. I showed that the complex FhuA-pb5 is very stable and determined the "plug" domain of FhuA as a novel interaction site of pb5. Complex formation does not induce major rearrangements of pb5 and/or FhuA. Only subtle conformational changes during complex formation, at the secondary structures level, were identified and assigned to pb5. These changes would be at the origin of the signal transmission to the phage. 3D crystals (8 À) and 2D crystals (3 À) were obtained. Small-angle neutron and X-ray scattering studies yielded a model of pb5 isolated and within the complex. These models are in agreement with the low resolution structure of pb5 and the complex, obtained by electron microscopy, and show that the binding interface covers the entire extracellular section of FhuA. Pb5 binds to FhuA by one of its ends in a way that its major axis and the axis of the FhuA barrel are aligned. Unlike the various RBPs described so far, pb5 seems composed of a single domain and is present in one copy at the distal end of the T5's straight fiber. Furthermore, I worked on the overexpression, purification, characterization and the structure of pb9, a protein that was located in the conical part of the tail of T5. The first experimental electron density map is obtained and the resolution of its atomic structure is underway
Price, Jamie H., Aimee Govett, Misty Davis, Robyn Ivester, Teresa Howard i Lisa Messimer. "PBL Meets PBL: Project-Based Learning Meets Planet-Based Learning". Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6025.
Pełny tekst źródłaSepúlveda, Valenzuela Gabriel Ignacio. "Evaluación de la diversidad genética de los genes PB2, PB1 y PA del complejo polimerasa del virus influenza tipo A de origen porcino en Chile". Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/171772.
Pełny tekst źródłaEl virus influenza A (FLUAV) ha sido ampliamente estudiado debido a su gran importancia en salud pública y animal. Una de las razones de esto es su gran variabilidad genética otorgada en gran medida por el proceso de reassorment o reordenamiento genético. Este estudio consistió en la determinación de la diversidad genética de los genes que componen el complejo polimerasa del virus, es decir, los genes que codifican para la polimerasa básica 2 (PB2), la polimerasa básica 1 (PB1) y la polimerasa ácida (PA) de virus aislados de planteles porcinos de producción intensiva en Chile y evidenciar procesos de reordenamientos genéticos independientes de dichos genes. Para esto, se analizaron 2824 muestras desde 33 planteles porcinos mediante diagnóstico viral por RT-PCR en tiempo real, aislamiento viral, amplificación de segmentos virales por RT-PCR multisegmento y secuenciación por Illumina. Se obtuvieron un total de 89 secuencias genómicas de PB2 y 92 tanto de PB1 como de PA. Luego se realizó un análisis filogenético con estas secuencias nucleotídicas, más secuencias de referencia mediante el método Maximum likelihood. Todas las secuencias para los tres genes estudiados pertenecen al linaje pandémico del 2009. Se constató además la presencia de reordenamientos de estos genes en aproximadamente un 35% de los casos. Estos resultados permitieron conocer sobre la diversidad genética de los genes que componen el complejo polimerasa de FLUAV en Chile y pesquisar fenómenos de reordenamientos de estos. Además, permitieron evidenciar posibles quiebres de bioseguridad en parte de las producciones porcinas intensivas en Chile, debido a las relaciones filogenéticas encontradas entre virus de diferentes planteles. Futuros estudios son necesarios para confirmar y entender estos hallazgos
The influenza A virus (FLUAV) has been extensively studied for the importance in public and animal health. The virus presented high genetic diversity, due to in part, by the reassortment events. The aim of this study it was to determinate the genetic diversity of the segments 1 (PB2), 2 (PB1) and 3 (PA) of FLUAV isolated from swine in intensive production farms in Chile and too evidence reassortment events in these genes. For this, 2824 samples were collected from 33 pig farms. Real time RT-PCR, viral isolation, and full genome sequencing were performed. A total of 89 genomic sequences of PB2 and 92 genomic sequences for PB1 and PA were obtained. Using phylogeny, we determinate that all segment belonged into the pandemic 09 cluster. The results suggest reassortment events of these genes in approximately 35% of the cases. This is the first study about the genetic diversity of the PB2, PB1 and PA, internal genes and to evidence reassortment events of them in swine population. In addition, the phylogeny suggests direct or indirect transmission between farms. Further studies are needed to better understand the viral dynamic of polymerase genes
FONDECYT 11170877 y ANILLO ACT 1408
Friedman, Sandra de Castro. "Arcabouço teórico para discussões sobre o panorama multifacetado da privacidade na era digital". Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/12371.
Pełny tekst źródłaApproved for entry into archive by Daniella Sodre (daniella.sodre@ufpe.br) on 2015-03-13T12:59:12Z (GMT) No. of bitstreams: 2 Dissertaçao Sandra Friedman.pdf: 3093791 bytes, checksum: a8717835d5925a6a173e5d53ca7694bb (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)
Made available in DSpace on 2015-03-13T12:59:12Z (GMT). No. of bitstreams: 2 Dissertaçao Sandra Friedman.pdf: 3093791 bytes, checksum: a8717835d5925a6a173e5d53ca7694bb (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2013-08-30
Ameaças como vazamento de dados, roubo de identidade, vigilância, criação de perfis e dossiês, bem como as políticas de privacidade mutantes das redes sociais estão frequentemente relacionadas com danos à reputação e perda da privacidade. Este estudo faz uma explanação geral da legislação no contexto internacional e um exame crítico em artigos, documentos e pesquisas de opinião, analisando as questões de privacidade da informação – e as definições de privacidade como um todo – investigando as diferentes facetas da privacidade e como a tecnologia nos desafia a realinhar nossas expectativas de privacidade. Trabalhamos com a hipótese de que o cuidado com a proteção à privacidade de dados pessoais tende a figurar entre as qualidades buscadas por usuários de aplicativos de software, e, portanto, deverá se constituir em elemento fundamental de vantagem competitiva no mercado de aplicativos. Nossa hipótese foi suportada pela descoberta de estratégias e uma miríade de soluções de software para a proteção da privacidade nas fases de coleta, armazenamento, processamento e disseminação de informações. A privacidade está em necessidade urgente de preservação e as estratégias regulatórias vigentes parecem não estar à altura da tarefa. As empresas, que levam em conta a privacidade como um valor inerente aos projetos e desenvolvimento de seus produtos e tecnologias, estimulam o espírito de inovação e destacam-se no mercado, construindo um relacionamento de confiança com seus clientes e usuários. Espera-se trazer conhecimento científico a estudantes e profissionais comprometidos com a ética, com os valores de liberdade e autonomia e interessados no tema privacidade da informação.
Lind, Herta. "Meningsfullt lärande med PBL?" Thesis, Linköping University, Department of Educational Science (IUV), 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-888.
Pełny tekst źródłaArbetet handlar om huruvida man kan få till ett meningsfullt lärande genom att använda sig av metoden PBL, problembaserat lärande, i grundskolan. Jag gör en kort presentation av lärande under 1900-talet för att därefter koncentrera mig på tre pedagoger, Marton, Säljö och Dewey. Utifrån dessa tre pedagogers syn på lärande undersöker jag PBL. Jag beskriver hur metoden PBL fungerar och hur den är uppbyggd. Mycket i PBL överensstämmer med vad Marton, Säljö och Dewey anser vara ett lärande som ger bra resultat. Som motvikt har jag tagitmed Inger Enkvist som står för en helt annan syn på hur skolan ska arbeta.
Andersen, Alexander. "Regional fysisk planering - I vägvalet om att planera enligt PBL eller utanför PBL". Thesis, Blekinge Tekniska Högskola, Institutionen för fysisk planering, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-22107.
Pełny tekst źródłaCuba, B. Elmer. "Estimación del PBI potencial y de la brecha del PBI: Perú 1970-1995". Economía, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/117258.
Pełny tekst źródłaHarris, Joel Mark. "Static characteristics and rotordynamic coefficients of a four-pad tilting-pad journal bearing with ball-in-socket pivots in load-between-pad configuration". [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3194.
Pełny tekst źródłaLantto, Joni, i Henri Lehtonen. "Medborgarinflytande i detaljprocessen : En jämförelse mellan PBL 1987 samt PBL 2010 ur ett demokratiperspektiv". Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183582.
Pełny tekst źródłaPersson, Filip. "Med PBL i geografiundervisningens centrum". Thesis, Malmö högskola, Fakulteten för lärande och samhälle (LS), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-36130.
Pełny tekst źródłaVlk, Bronislav. "Možnosti videokonferencí v PBX Asterisk". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219738.
Pełny tekst źródłaHensley, John Eric. "Rotordynamic coefficients for a load-between-pad, flexible-pivot tilting pad bearing at high loads". Texas A&M University, 2006. http://hdl.handle.net/1969.1/4404.
Pełny tekst źródłaErrami, Jalal. "Modélisation d'un simple brin d'ADN : Configuration en "épingle à cheveux"". Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2007. http://tel.archives-ouvertes.fr/tel-00156784.
Pełny tekst źródłaIto, Edson Noriyuki. "Estudos microrreológicos da blenda PBT/SAN". Universidade Federal de São Carlos, 2006. https://repositorio.ufscar.br/handle/ufscar/647.
Pełny tekst źródłaFinanciadora de Estudos e Projetos
This work was motivated by the need of a better understanding of the microrheological characteristics of polybutylene terephthalate, PBT, polymer blends, such as the matrix phase PBT and the styrene-acrylonitrile, SAN copolymer as dispersed phase. The main purpose of the microrheological studies carried out was to analyze the rheological behavior and the morphology, as well as their correlation, in the preparation of the PBT/SAN immiscible blend, with and without the use of an interfacial compatibilizer. The rheological behavior was analyzed by torque rheometry, rotational rheometry with parallelplates geometry, and capillary rheometry. The interfacial tensions were measured by the modified ellipsoidal drop retraction method, using an optical polarized light microscope coupled to a hot stage. Two complementary techniques were used in the morphological analyses: scanning electron microscopy (SEM) with tetrahydrofuran (THF) extraction of the dispersed phase, and transmission electron microscopy (TEM) with rutene tetroxide (RuO4) deposition in the dispersed phase. The interfacial tension between the PBT polymer and the SAN copolymer was found to increase as the molar mass of the PBT increased. The use of rotational rheometry with parallel plates at low shear rates allowed the increase in viscosity to be quantified as a function of the reaction of the polymeric macromolecules in the PBT/SAN blend compatibilized or not with the interfacial compatibilizer, the MMA-GMA-EA copolymer. Based on the morphological characterizations, an analysis was made of the fibril formation mechanisms, break up and coalescence of the particles of dispersed phase and their interactions with the addition of interfacial compatibilizers. The rotational rheometry at low shear rates proved to be extremely efficient in the analysis of blend compatibilization, which is usually analyzed by torque rheometry. It was checked that, at high shear rates, the viscosity ratio influenced the formation of more finely dispersed phases.
O motivo que levou à realização deste trabalho de doutorado consistiu na necessidade de um melhor entendimento das características microrreológicas de blendas poliméricas constituídas de poli(tereftalato de butileno), PBT, como fase matriz, e do copolímero estireno-acrilonitrila, SAN, como fase dispersa. Os estudos microrreológicos realizados tiveram como enfoque principal analisar o comportamento reológico e a morfologia, bem como suas correlações na preparação da blenda imiscível PBT/SAN, com e sem a utilização de um compatibilizante interfacial. Nas análises do comportamento reológico, foram utilizadas reometria de torque, reometria rotacional na geometria de placas paralelas e reometria capilar. As medidas de tensões interfaciais foram realizadas através do método de retração de gotas elipsoidais modificado, utilizando-se de um microscópio óptico com luz polarizada acoplado a um estágio a quente. Nas análises morfológicas, foram utilizadas duas técnicas complementares, através de microscopia eletrônica de varredura (MEV) com extração da fase dispersa com tetrahidrofurano (THF) e por microscopia eletrônica de transmissão (MET) com a deposição de tetróxido de rutênio (RuO4) sobre a fase dispersa. Utilizando-se do método de retração de gota modificado, verificou-se que a tensão interfacial entre o polímero PBT e o copolímero SAN aumenta com o aumento da massa molar do PBT. Utilizando-se da reometria de placas paralelas a baixas taxas de cisalhamento, foi possível quantificar o aumento de viscosidade em função da reação das macromoléculas poliméricas na blenda PBT/SAN, compatibilizada ou não com o agente de compatibilização interfacial (o terpolímero metacrilato de metilametacrilato de glicidila-acrilato de etila, MMA-GMA-EA). Por meio das caracterizações morfológicas, foi possível analisar os mecanismos de formação de fibrilas, cominuição e coalescência das partículas de fase dispersa e de suas interações com a adição de agentes de compatibilização interfacial. A técnica de reometria rotacional de placas paralelas em baixas taxas de cisalhamento mostrou-se extremamente eficiente na análise de compatibilização de blendas, que, na maioria das vezes, é feita através de reometria de torque. Verificou-se que, a altas taxas de cisalhamento, a razão de viscosidade influencia a formação de fases mais finamente dispersas em função da taxa de cisalhamento aplicada à blenda PBT/SAN.
Sestak, Mark R. Carleton University Dissertation Computer Science. "Traffic flow monitoring in PBX networks". Ottawa, 1990.
Znajdź pełny tekst źródłaBenýšek, Jiří. "Vazba GSM modemu na PBX Asterisk". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218255.
Pełny tekst źródłaOrsák, David. "Zabezpečení Open source PBX proti útokům". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219480.
Pełny tekst źródłaHynek, Luboš. "Metody zajištění IP PBX proti útokům". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220328.
Pełny tekst źródłaJaneček, Václav. "Open source PBX Kamailo a OpenSIPs". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220656.
Pełny tekst źródłaBednář, Vít. "Implementace protokolu SIP v PBX Asterisk". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-317016.
Pełny tekst źródła