Gotowe bibliografie tematyczne / Paraplegic men

Gotowa bibliografia na temat „Paraplegic men”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 20 lutego 2023

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Artykuły w czasopismach na temat "Paraplegic men"

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Dionyssiotis, Yannis, Konstantina Petropoulou, Christina-Anastasia Rapidi, Panagiotis Papagelopoulos, Nikolaos Papaioannou, Antonios Galanos, Paraskevi Papadaki i Georgios P. Lyritis. "Body Composition in Paraplegic Men". Journal of Clinical Densitometry 11, nr 3 (lipiec 2008): 437–43. http://dx.doi.org/10.1016/j.jocd.2008.04.006.

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Gross, A. J., D. H. Sauerwein, J. Kutzenberger i R. H. Ringert. "Penile prostheses in paraplegic men". British Journal of Urology 78, nr 2 (sierpień 1996): 262–64. http://dx.doi.org/10.1046/j.1464-410x.1996.08021.x.

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Pruthi, N., Chanchal Pruthi i P. Sutharamn. "Protective Clothing for Paraplegic Men". Journal of Human Ecology 20, nr 2 (październik 2006): 103–8. http://dx.doi.org/10.1080/09709274.2006.11905911.

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Gass, G. C., E. M. Camp, E. R. Nadel, T. H. Gwinn i P. Engel. "Rectal and rectal vs. esophageal temperatures in paraplegic men during prolonged exercise". Journal of Applied Physiology 64, nr 6 (1.06.1988): 2265–71. http://dx.doi.org/10.1152/jappl.1988.64.6.2265.

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This study investigated the rectal (Tre), esophageal (Tes), and skin (Tsk) temperature changes in a group of trained traumatic paraplegic men pushing their own wheelchairs on a motor-driven treadmill for a prolonged period in a neutral environment. There were two experiments. The first experiment (Tre and Tsk) involved a homogeneous group (T10-T12/L3) of highly trained paraplegic men [maximum O2 uptake (VO2max) 47.5 +/- 1.8 ml.kg-1.min-1] exercising for 80 min at 60–65% VO2max.Tre and Tsk (head, arm, thigh, and calf) and heart rate (HR) were recorded throughout. O2 uptake (VO2), minute ventilation (VE), CO2 production (VCO2), and heart rate (HR) were recorded at four intervals. During experiment 1 significant changes in HR and insignificant changes in VCO2, VE, and VO2 occurred throughout prolonged exercise. Tre increased significantly from 37.1 +/- 0.1 degrees C (rest) to 37.8 +/- 0.1 degrees C after 80 min of exercise. There were only significant changes in arm Tsk. Experiment 2 involved a nonhomogeneous group (T5-T10/T11) of active paraplegics (VO2max 39.9 +/- 4.3 ml.kg-1.min-1) exercising at 60–65% VO2max for up to 45 min on the treadmill while Tre and Tes were simultaneously recorded. Tes rose significantly faster than Tre during exercise (dT/dt 20 min: Tes 0.050 +/- 0.003 degrees C/min and Tre 0.019 +/- 0.005 degrees C/min), and Tes declined significantly faster than Tre at the end of exercise. Tes was significantly higher than Tre at the end of exercise. Our results suggest that during wheelchair propulsion by paraplegics, Tes may be a better estimate of core temperature than Tre.
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Sindrup, J. H., H. Wroblewski, J. Kastrup i F. Biering-Sørensen. "Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men". Clinical Science 82, nr 1 (1.01.1992): 47–54. http://dx.doi.org/10.1042/cs0820047.

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1. Lower-leg subcutaneous adipose tissue blood flow rates were measured over 12-20 h under ambulatory conditions by means of the 133Xe-washout technique in nine paraplegic men, all with complete spinal cord lesions at or below the Th 6 level, and in nine age-matched healthy men. Portable CdTe(Cl) detectors and datastorage units were used. 2. The central and local sympathetic vasoconstrictive activity at the lower leg was measured under laboratory conditions by means of the l33Xe-washout technique and a stationary NaI(TI) detector system. 3. The paraplegic men were found to have intact central and local sympathetic vasoconstrictive activity in their lower legs. Moreover, they all had a nocturnal hyperaemic blood flow phase of the same magnitude and duration as the control subjects. 4. The possibility that the somaesthetic nerves play a role in the hyperaemic response could be excluded, as all the paraplegic men suffered from complete lower-leg somaesthetic denervation. 5. A significant correlation was found between the time of going to bed and the nightly hyperaemic response in the right and left lower legs (P < 0.01). 6. It is concluded that the present data are in accordance with the concept of a central nervous or humoral elicitation of nocturnal hyperaemia, although local metabolic and other factors might participate as well. Paraplegic men have an intact regulation of the postural and nocturnal changes in peripheral blood flow whether of central sympathetic or humoral origin.
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BRINDLEY, G. S., D. SAUERWEIN i W. F. HENDRY. "Hypogastric Plexus Stimulators for Obtaining Semen from Paraplegic Men". British Journal of Urology 64, nr 1 (lipiec 1989): 72–77. http://dx.doi.org/10.1111/j.1464-410x.1989.tb05526.x.

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Blockmans, D., i O. Steeno. "Physostigmine as a Treatment for Anejaeulation with Paraplegic Men/Physostigmin als Behandlung bei Anejakulation infolge Paraplegie". Andrologia 20, nr 4 (24.04.2009): 311–13. http://dx.doi.org/10.1111/j.1439-0272.1988.tb00692.x.

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Gass, G. C., i E. M. Camp. "Effects of prolonged exercise in highly trained traumatic paraplegic men". Journal of Applied Physiology 63, nr 5 (1.11.1987): 1846–52. http://dx.doi.org/10.1152/jappl.1987.63.5.1846.

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This study investigated the cardiovascular and metabolic responses to prolonged wheelchair exercise in a group of highly trained, traumatic paraplegic men. Six endurance-trained subjects with spinal cord lesions from T10 to T12/L3 underwent a maximal incremental exercise test in which they propelled their own track wheelchairs on a motor-driven treadmill to exhaustion to determine maximal O2 uptake (VO2max) and related variables. One week later each subject exercised in the same wheelchair on a motorized treadmill at 60–65% of VO2max for 80 min in a thermoneutral environment (dry bulb 22 degrees C, wet bulb 17 degrees C). Approximately 10 ml of venous blood were withdrawn both 20 min and immediately before exercise (0 min), after 40 and 80 min of exercise, and 20 min postexercise. Venous blood was analyzed for hematocrit (Hct), hemoglobin (Hb), and lactate, and the separated plasma was analyzed for glucose, K+, Na+, Cl-, free fatty acid (FFA), and osmolality. VO2, CO2 production (VCO2), minute ventilation (VE), respiratory exchange ratio (R), net efficiency, and wheelchair strike rate were determined at four intervals throughout the exercise period. Data were analyzed with an analysis of variance repeated-measures design and a Scheffe post hoc test. VO2max was 47.5 +/- 1.8 (SE) ml.min-1.kg-1 with maximal VE BTPS and maximal heart rate (HR) being 100.1 +/- 3.8 l/min and 190 +/- 1 beats/min, respectively. During prolonged exercise there were no significant changes in VO2, VCO2, VE, R, net efficiency, wheelchair strike rate, and lactate, glucose, and Na+ concentrations. Significant increases occurred in HR, FFA, K+, Cl-, osmolality, Hb, and Hct throughout exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cutajar, Ruth, i Anne Roberts. "The Relationship between Engagement in Occupations and Pressure Sore Development in Saudi Men with Paraplegia". British Journal of Occupational Therapy 68, nr 7 (lipiec 2005): 307–14. http://dx.doi.org/10.1177/030802260506800704.

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Various research studies have explored the factors that predispose people with spinal cord injuries to pressure sore development. Two hundred risk factors have been associated with pressure sore occurrence. One of the variables commonly reported to affect pressure sore occurrence is a decreased level of activity (Vidal and Sarrias 1991, Fuhrer et al 1993). This concurs with the philosophy of occupational therapy that a reduction in activity can generate pathology (Miller et al 1988). This research study investigated whether decreased participation in occupational activities (work, leisure and activities of daily living) was related to pressure sore occurrence in paraplegic men. The sample was selected randomly from the occupational therapy discharge files of a rehabilitation facility in Saudi Arabia. The data were collected by means of a telephone questionnaire from a total of 58 men, over a 3-month period. The study showed that there was a large increase in unemployment in paraplegic men following injury (from 10% to 59%) and, as might be expected, manual workers were more vulnerable than office workers. The study found no significant association between pressure sore occurrence and whether or not the individual was employed. However, it showed a statistically significant association between unemployment and pressure sores severe enough to lead to hospitalisation. The study also found a statistically significant association between individuals' independence in activities of daily living and the number of pressure sores that they had reported in the last 2 years. These findings indicate the potential importance of clients remaining occupationally active for their wellbeing and the significant contribution that occupational therapists can make by enabling rehabilitation of occupational activities.
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Mungovan, Sean, Greg Gass i Elizabeth Gass. "Effects Of Lower Limb Elevation And Compression On Cardiovascular Function In Men Who Are Paraplegic". Medicine & Science in Sports & Exercise 37, Supplement (maj 2005): S313. http://dx.doi.org/10.1249/00005768-200505001-01625.

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Rozprawy doktorskie na temat "Paraplegic men"

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Mungovan, Sean F., i n/a. "The Effect of Elevation and Venous Occlusion Pressure on Cardiovascular Function in Physically Active Men Who Are Paraplegic". Griffith University. School of Physiotherapy and Exercise Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040917.084824.

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The purpose of the present investigation was to: 1) Determine the relationship between cardiac output (estimated using the acetylene rebreathing methodology) and oxygen consumption in a homogeneous group of men who are paraplegic. 2) Investigate whether lower limb elevation increases stroke volume and decreases heart rate at rest and during submaximal arm exercise. 3) Investigate whether the application of constant circumferential pneumatic pressure applied to dependent lower limbs increases stroke volume and decreases heart rate at rest and during submaximal arm exercise.
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Mungovan, Sean F. "The Effect of Elevation and Venous Occlusion Pressure on Cardiovascular Function in Physically Active Men Who Are Paraplegic". Thesis, Griffith University, 2004. http://hdl.handle.net/10072/365190.

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The purpose of the present investigation was to: 1) Determine the relationship between cardiac output (estimated using the acetylene rebreathing methodology) and oxygen consumption in a homogeneous group of men who are paraplegic. 2) Investigate whether lower limb elevation increases stroke volume and decreases heart rate at rest and during submaximal arm exercise. 3) Investigate whether the application of constant circumferential pneumatic pressure applied to dependent lower limbs increases stroke volume and decreases heart rate at rest and during submaximal arm exercise.
Thesis (Masters)
Master of Philosophy (MPhil)
School of Physiotherapy and Exercise Science
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Louw, Helenard Kingsley Madiba. "“Half a man?” Still a human: Narratives on the impact of a spinal cord injury on coloured men living with paraplegia". Master's thesis, Faculty of Humanities, 2019. http://hdl.handle.net/11427/30536.

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There is an overwhelming body of research in the Global North that focuses on the narratives of the impact of a spinal cord injury on men living with paraplegia, while existing research in South Africa and the Global South lacks knowledge on these narratives. This study explored the narratives on the impact of a spinal cord injury on fifteen coloured men living with paraplegia on the Cape Flats. This study adopted a life story approach, as a primary research methodology, and examined how these men constructed and told their life stories, how meanings and experiences of living with paraplegia were conveyed, and how they negotiated the intersection of disability, masculinity, race, class and sexuality in their lives. A participatory action research (PAR) methodology, photo-voice, was used as a complimentary methodology which depicted how these men visually represented the way they think main-stream society sees them and the way they see themselves. Drawing on Frank’s (1995) work on narratives and illness, this study used two life stories and theoretically shows how life stories with a central focus on paraplegia as a spinal cord injury are constructed and narrated. Through a narrative thematic analysis, themes and sub-themes highlighted the complexities and tensions in the construction and performance of masculinities after the injury. The following themes emerged from the narratives: feelings of shame and infantilization, a loss of independency, dehumanizing social perceptions of being a man living with a disability, vulnerability to violence, and challenges in sexual intercourse and intimacy. The narratives also show that a man in this context can develop a positive sense of self through learning to live independently, strategies to prevent violence, redefining sex, and redefining what it means to be a man and ‘disabled’.
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Sishuba, Gladys Jabulile Elizabeth. "Sexuality in the male paraplegic". Diss., 1996. http://hdl.handle.net/10500/16048.

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The aim of the study was to provide a platform for the male paraplegic to explore the implications of the disability on his sexuality. A qualitative research method was utilised. In-depth interviews were conducted during October 1995 and February 1996 using a sample often black male in-patients at the beginning of their rehabilitation program and during their initial hospitalisation at Kalafong Hospital in Pretoria. The results of the study indicated that the newly injured person has a great need to talk about the impact of the injury on his life. Three major areas of concern emerged: physical appearance, loss of control and independence and relationships. All three areas were perceived to have an impact on sexuality. Rejection of the redefined intimacy by the able-bodied spouse, was perceived as a threat to sexual adjustment.
Social Work
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Shoukier, Moneef. "Zur molekularen und funktionellen Charakterisierung von Mutationen in den SPG4- und SPG7- Genen". Thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B18B-8.

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Eisenberg, André. "Molekulare Charakterisierung des COPS5-Gens und seines Genproduktes als Kandidat für die Spastische Spinalparalyse". Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B1B3-C.

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Książki na temat "Paraplegic men"

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Martin, Chris. Greenwich mean time. Southwold, Suffolk: ScreenPress Books, 1999.

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Proulx, Monique. Invisible man at the window. Vancouver: Douglas & McIntyre, 1994.

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Invisible man at the window. Vancouver: Douglas & McIntyre, 1994.

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Kilby, Joan. Family matters. Toronto: Harlequin, 2004.

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Inoue, Takehiko. Real. Redaktorzy Werry John (Translator), Dutro Steve, Whitley Yukiko i Nakatani Andy. San Francisco: VIZ Media, 2009.

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1937-, Taylor Jim, red. Rick Hansen: Man in motion. Vancouver: Douglas & McIntyre, 1987.

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McFadden, Maryann. The book lover. Vienna, NJ: Three Women Press, 2012.

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Moyes, Jojo. Mig før dig. Wyd. 2. Kbh: Cicero, 2013.

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Moyes, Jojo. Me Before You. London: Penguin Books Ltd, 2016.

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Moyes, Jojo. Me Before You. London, England: Penguin Books, 2012.

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Części książek na temat "Paraplegic men"

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Dionyssiotis, Yannis. "Body Composition in Spinal Cord Injured–Paraplegic Men". W Handbook of Anthropometry, 2317–39. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-1788-1_143.

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van der Kooij, Herman, Edwin van Asseldonk, Gijs van Oort, Victor Sluiter, Amber Emmens, Heide Witteveen, Nevio Luigi Tagliamonte i in. "Symbitron: Symbiotic Man-Machine Interactions in Wearable Exoskeletons to Enhance Mobility for Paraplegics". W Biosystems & Biorobotics, 361–64. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-01887-0_69.

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Martiñón, Susana, i Ricardo Hernández-Miramontes. "Use of Exoskeletons in the Treatment and Rehabilitation of Paraplegia Patients". W Paraplegia. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94920.

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This chapter presents a review that includes five robotic exoskeletons used in the rehabilitation of paraplegic patients, highlighting the qualities of each one and offering the doctor and the rehabilitator a tool to select the exoskeleton that is most appropriate to the needs of their patient and a more satisfying and integral therapy. A systematic search was carried out in different platforms of scientific interest, the publications that met the inclusion criteria were selected. The information collected was classified and synthesized, resulting in a review that covers the five most relevant exoskeletons for the rehabilitation of paraplegic patients. Concluding with a tool that helps the therapist select the most appropriate exoskeleton for each patient.
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Kumar, Kishore R., Carolyn M. Sue, Alexander Münchau i Christine Klein. "Hereditary Spastic Paraplegia". W Neurogenetics, 139–42. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199383894.003.0025.

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Levin, Morris. "Post-traumatic Paraplegia". W Emergency Neurology, 93–96. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199862856.003.0020.

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Stevenson, Roger E., Charles E. Schwartz i R. Curtis Rogers. "Goldblatt Spastic Paraplegia Syndrome". W Atlas of X-Linked Intellectual Disability Syndromes, 96. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199811793.003.0047.

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Stevenson, Roger E., Charles E. Schwartz i R. Curtis Rogers. "XLID-Spastic Paraplegia-Athetosis". W Atlas of X-Linked Intellectual Disability Syndromes, 295. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199811793.003.0152.

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Kinsman, Michael, Kyle Smith i Mariah Sami. "Intractable Spinal Spastic Paraplegia". W Functional Neurosurgery, C14—C14.P70. Oxford University PressNew York, 2019. http://dx.doi.org/10.1093/med/9780190887629.003.0014.

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Abstract Spasticity is a common medically refractory sequela of spinal cord injury. When medicines such as baclofen and tizanidine do not provide adequate benefit or when the side effects of these medications are impairing quality of life, surgical strategies can be considered. Percutaneous thoracolumbar radio-frequency rhizotomies and intrathecal baclofen delivery are two effective strategies for intractable spasticity. For patients being considered for intrathecal pump placement, an intrathecal trial of baclofen via lumbar puncture with pre- and postinjection assessment of spasticity is prudent. For patients with intrathecal baclofen pumps, baclofen withdrawal due to system failure is a serious complication that must be managed aggressively.
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Stevenson, Roger E., Charles E. Schwartz i R. Curtis Rogers. "XLID-Spastic Paraplegia, Type 7". W Atlas of X-Linked Intellectual Disability Syndromes, 293. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199811793.003.0151.

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Wijdicks, Eelco F. M., Alejandro A. Rabinstein, Sara E. Hocker i Jennifer E. Fugate. "Acute Paraplegia After Aortic Surgery". W Neurocritical Care, 107–12. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190602659.003.0015.

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Streszczenia konferencji na temat "Paraplegic men"

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Kagawa, Takahiro, i Yoji Uno. "Gait pattern generation for a power-assist device of paraplegic gait". W RO-MAN 2009 - The 18th IEEE International Symposium on Robot and Human Interactive Communication. IEEE, 2009. http://dx.doi.org/10.1109/roman.2009.5326348.

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Fenner, Fernanda, Francisco José Luis de Sousa, Hilton Mariano da Silva Jr i Andrei Fernandes Joaquim. "Aortic thrombosis presenting with low back pain and paraplegia: a medical alert". W XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.741.

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Context:The importance of a thorough neurological examination of the patient should always include research into differential diagnoses such as vascular syndromes, increasingly common in our population. Case report: A 46-year-old man evaluated and screened by the Neurosurgery’s department team, after an initial complaint of sudden onset low back pain and acute weakness in both lower limbs. The patient was healthy before the event. Patient didn’t have pathological history or use of chronic medications, referring only to use sporadic medication for sexual impotence, approximately 6 months ago. Observation revealed pale cold lower limbs, with livedo reticularis. Pulses of the femoral artery were absent bilaterally. Neurological examination revealed complete flaccid paraplegia with neurological level of L1. Below this level loss of pain, light touch and temperature sensation (0/2 in all dermatomes on both extremities), muscle weakness (0/5 in all neurotomes bilaterally), absent tendon and plantar reflexes. Axial tomography of the lumbar spine didn’t reveal vertebral lesions or pressure within the spinal canal. Consultation of the vascular surgeon confirmed absence of blood flow through femoral arteries and emergency angiotomography of the abdominal aorta showed complete occlusion of the descending aorta, upper renal arteries. Patient underwent percutaneous embolectomy treatment, with successful revascularization of lower extremities; unfortunately died about 10 hours after surgery due the development of revascularization syndrome. Conclusions: Acute aortic occlusion is a catastrophic event and can present itself as flaccid paraplegia, leading to misdiagnosis and loss of valuable time for positive outcome. Vascular examination should always be performed on each patient with neurological deficit in lower limbs, especially patients with clinical history of peripheral vascular disease. Immediate start of treatment is imperative to improve survival rates.
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Mneimneh, Farah, Nesreen Ghaddar, Kamel Ghali, Charbel Moussalem i Ibrahim Omeis. "Modeling the Effect of Cooling Vest on Body Thermal Response of People With Paraplegia During Exercise". W ASME 2019 Heat Transfer Summer Conference collocated with the ASME 2019 13th International Conference on Energy Sustainability. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/ht2019-3474.

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Abstract Persons with thoracic spinal cord injury (SCI), also named as people with paraplegia (PA), are encouraged to participate in sport activities for sake of improving their quality of life and health. Yet, heat strain is a major consequence of SCI after which the body loses its ability to regulate its temperature. Disruption in body temperature regulation and instability in core temperature (Tcr) endangers the patient health especially when subjected to extreme ambient conditions or high level of physical activity. Since thermophysiology is disrupted after SCI, using conventional personal cooling methods may not be effective on PA in a way similar to that of able-bodied people (AB). Experimental studies evaluated the effect of phase change material (PCM) and ice cooling vests on thermal response of PA during exercise. Results showed no change in Tcr values for both types of vest during exercise. This study aims at studying the effectiveness of PCM cooling vest for PA during exercise at intensity level of 6.5 MET within 21.1–23.9 °C room temperature and 50% relative humidity. A multi-segmented bioheat model of PA coupled with PCM cooling vest model (fabric-PCM-PA model) was deployed to predict Tcr values at different design conditions of the vest. Segmental core and skin temperatures profiles and the sensible and latent heat losses were obtained for torso segments to assess the percentage of enhancement in the cooling vest performance. Results showed that Tcr value of the body and Tcr values of the torso segments didn’t change at different design conditions of the vest; yet sensible heat losses were increased for all torso segments and latent heat losses were reduced. Decreases in latent heat losses affected Tsk values at the torso. Simulations were performed using fabric-PCM model integrated with PA bioheat model applying variation of skin coverage area, melting point of PCM and combination of both designs. An effective design of the vest for PA was found when using PCM packet at 10°C melting point and coverage area about 40% of torso because sensible heat losses were the highest compared to the other design cases of the vest.
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Pinto, Wladimir Bocca Vieira de Rezende, Bruno de Mattos Lombardi Badia, Igor Braga Farias, José Marcos Vieira de Albuquerque Filho, Roberta Ismael Lacerda Machado, Paulo Victor Sgobbi de Souza i Acary Souza Bulle Oliveira. "Expanding the neurological and imaging phenotype of women with adult-onset X- linked Adrenoleukodystrophy." W XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.019.

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Background: X-linked Adrenoleukodystrophy (X-ALD) represents a key inherited metabolic disorder in neurological practice, representing an important differential diagnosis in different neurological contexts. Symptomatic female patients have been scarcely studied in large cohorts. Objectives: Evaluation of clinical, laboratory and genetic findings from a Brazilian cohort of women with X-ALD. Methods, design and setting: We performed a retrospective observational study of clinical, biochemical, genetic, neuroimaging and neurophysiological aspects of 10 Brazilian female patients with X-linked Adrenoleukodystrophy under clinical follow-up at the Neurometabolic Unit, Division of Neuromuscular Diseases, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. Results: Mean age at diagnosis was 46.2 years and at symptom-onset was 39 years. Female patients presented with spastic paraparesis and neurogenic bladder (60%), cognitive decline (50%), demyelinating sensorimotor polyneuropathy (40%), cerebellar ataxia (30%), epilepsy (20%), apraxia and psychotic symptoms (10%). The most common misdiagnosis were Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia. The main neuroimaging findings were corticospinal tract hyperintensity and cervical and thoracic spinal cord atrophy (60%), unspecific white matter changes (40%) and typical parieto-occipital leukodystrophy. All patients had abnormal profiles of plasma very-long chain fatty acids, all with elevated C26 levels and 80% with elevated C24 levels, but all with abnormally raised C26:C22 and C26:C24 ratio. The most common pathogenic variant observed was c.311G>A (p.Arg104His) (60%). Conclusions: Female patients with ABCD1 pathogenic variants must be carefully evaluated for neuropsychiatric disturbances and followed-up until elderly due to the common occurrence of variable motor, autonomic and sensory compromise.
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Green, D., T. Cohn, P. Filbrandt, V. Ito, M. Y. Lee, J. Press i W. C. Vandenberg. "THROMBOEMBOLISM PROPHYLAXIS IN SPINAL CORD INJURY: FIXED VS ADJUSTED DOSE HEPARIN". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643596.

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We had previously estimated the incidence of deep vein thrombosis (DVT) in untreated spinal cord injury patients with complete motor paralysis to be 78% (Paraplegia 20:227, 1982). Therefore, we have begun to randomize patients to receive prophylaxis with either fixed dose heparin (5,000 u every 12 h subcutaneously) or adjusted dose heparin (mean dose, 13,890 u every 12 h). Treatment is started within 72 hrs of injury, and continued for 12 weeks. Nineteen subjects have received the fixed dose for 155 weeks, and 21 the adjusted dose for 153 weeks (p = N.S.). Patients have had daily clinical examinations for thromboembolism/bleeding, and weekly doppler flow and impedance plethysmography studies. All suspected DVTs have been confirmed by venography. The activated partial thromboplastin time (aPTT) with the fixed dose has average 26 ± 1.5s (S.D.) and with the adjusted dose, 39.6 ± 7.6s (p < 0.001). There have been 2 episodes of pulmonary embolism and 2 DVTs in the fixed dose group and 1 DVT in an adjusted dose patient whose aPTT never rose above 26s. The thromboses were noted after 2, 3, 3, 4, and 6 weeks of prophylaxis. Bleeding occurred in 2 patients on the adjusted dose regimen and required withdrawal of the heparin; no subject on the fixed dose bled. Our preliminary conclusion is that heparin prophylaxis significantly reduced the frequency of thromboembolism in spinal cord injury patients. While fewer and less severe thrombotic events have occurred in those receiving adjusted doses, the decrease has not yet reached statistical significance (x2 = 1.16). Furthermore, there appears to be a small, but definite risk of bleeding on this regimen. Thus, additional patients are being studied to determine the optimum use of heparin in this population.
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