Rozprawy doktorskie na temat „Paludisme – Complications (médecine) – Chez l'enfant”
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Vianou, Koffi Bertin. "Analyse du système hôte-parasite chez le patient pour un traitement adapté du neuropaludisme". Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES008.
Pełny tekst źródłaAnalysis of host-parasite interaction in cerebral malaria patients for appropriate treatment. Cerebral malaria, a fatal neurological complication of Plasmodium falciparum infection, occurs mainly in children under the age of five in sub-Saharan Africa. Despite treatment with intravenous artesunate, mortality remains high. A better understanding of the pathophysiology of cerebral malaria will enable us to envisage new, more suitable types of treatment. A cohort of Beninese children presenting with either uncomplicated malaria (UM) or cerebral malaria (CM) was set up. Children with CM were followed up at three days and 1 month (D3, D30) after their inclusion in the study (D0). This thesis focused on three aspects of the host response through the following questions: 1) Is endothelial activation impacted by the type of parasite infecting the host? 2) Is the monocyte response affected during cerebral malaria? and 3) Can we identify specific biomarkers of death during cerebral malaria? Using a co-culture model (Hbec-5i and infected red blood cells -iRBCs- from patients), we showed́ by RT-qPCR that cytoadherence of infected red blood cells from children with CM to endothelial cells increased the expression level of the Nrf2 gene on the endothelial cells. Comparison between clinical groups (CM and UM) of endothelial activation biomarkers measured in co-culture supernatants (with or without contact between the two cell types) showed no significant difference. These results suggest that cytoadherence of iRBCs to ECs alone is not sufficient to induce the production of activation biomarkers by ECs. Concerning the impact of cerebral malaria on monocyte response, the results showed a decrease in the proportion of non-classical monocytes and an alteration in the phagocytosis capacity of total monocytes during acute cerebral malaria (D0), followed by a return to a normal distribution at D3 and then D30. Non-classical monocytes showed a better opsonic and non-opsonic phagocytosis capacity compared with the phagocytosis capacity of the classical and intermediate monocytes. Transcriptional profiling of monocytes revealed that malaria severity was associated with altered expression of CD16, CR1, CR3, TLR2, involved in opsonic phagocytosis, and Tim3, involved in modulating parasite clearance. These results suggest that non-classical monocytes play a key role in the immune response set up during cerebral malaria, and that monocyte function would be controlled at the transcriptomic level. Further studies are required to identify the origin of these control mechanisms. Finally, plasma and urinary biomarkers were measured in children suffering from cerebral malaria. Univariate analysis revealed associations between the occurrence of death from CM and elevated plasma levels of TNF, IL-1, IL-10, CXCL9, Granzyme B, angiopoietin-2 and low levels of urinary PGEM. After multivariate logistic regression analysis, IL-8 appeared to be strongly associated with the occurrence of death for a plasma concentration 57.5 pg/mL at D0 followed by a rapid decreasing at D3 and D30 in surviving children. Biomarkers kinetics (D0, D3, D30) enabled us to distinguish a marker profiles of disease aggravation and resolution. This work reveals that cerebral malaria generates an activation of the antioxidant response by the vascular endothelium, as well as an alteration of the monocyte response via the diminished capacity of non-classical monocytes to eliminate iRBCs by phagocytosis. Furthermore, IL-8 as a biomarker associated with death also underlines the importance of the neutrophil response during cerebral malaria
Martin, Ingrid. "La chimiothérapie anticancéreuse chez l'enfant : complications, prévention et traitement". Paris 5, 1994. http://www.theses.fr/1994PA05P051.
Pełny tekst źródłaMasson, Philippe. "Etude des facteurs de risque de calcification rénale chez l'enfant broncho-dysplasique". Bordeaux 2, 1992. http://www.theses.fr/1992BOR23016.
Pełny tekst źródłaDuval, Cécile. "Thrombophlébite septique du sinus caverneux chez l'enfant : à propos d'un cas". Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M108.
Pełny tekst źródłaMoret, Valérie. "Le reflux gastro-oesophagien chez l'enfant". Paris 5, 1994. http://www.theses.fr/1994PA05P069.
Pełny tekst źródłaDuboze, Muriel. "Cécité acquise au cours de l'hémoglobinose SC : à propos d'un cas". Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M096.
Pełny tekst źródłaEl, Moutassir Zineb. "Risques et complications thromboemboliques au cours des maladies inflammatoires chroniques de l'intestin chez l'enfant". Paris 5, 1996. http://www.theses.fr/1996PA05P181.
Pełny tekst źródłaTölg, Cécilia. "Cholécystectomie chez l'enfant drépanocytaire : étude rétrospective des huit dernières années en Martinique". Bordeaux 2, 2000. http://www.theses.fr/2000BOR23095.
Pełny tekst źródłaViaud, Brigitte. "Les granulomatoses hépatiques infectieuses chez l'enfant : à propos de 8 cas". Bordeaux 2, 1993. http://www.theses.fr/1993BOR23100.
Pełny tekst źródłaRichier, Marie-Anne. "Aspects des mastoi͏̈dites de l'enfant au centre hospitalier de Pau". Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M053.
Pełny tekst źródłaFabry, Valérie. "Les deuxièmes tumeurs malignes de l'enfant : à propos de 14 observations". Bordeaux 2, 2001. http://www.theses.fr/2001BOR23008.
Pełny tekst źródłaDesroys, du Roure Laurence. "Auto-immunité et glycoprotéines lymphocytaires désialylées chez les sujets HIV-positifs". Paris 5, 1994. http://www.theses.fr/1994PA05P094.
Pełny tekst źródłaCorbin-Berrigan, Laurie-Ann. "Division de l'attention et traversée d'obstacle fixe chez une population d'enfants nés prématurément, en âge scolaire : implications cognitives et motrices". Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/29466/29466.pdf.
Pełny tekst źródłaThe aim of this study was to evaluate cognitive and motor performances of preterm children (24-36 weeks of gestation) aged 9 years (N=9; mean age: 9.41(0.65) years) and to compare them to full term born children’s (N=7; mean age: 9.39(0.62) years) performances. The protocol used, obstacle negotiation while dual tasking, was ecological in nature and represented motor and cognitive challenges that school-aged children face while performing recreational and sporting activities. Three dimentional movement analysis were done in order to quantify cognitive and motor performances. Participants walked under four conditions: unobstructed walking, obstructed walking, walking with Animal-Stroop task, and obstructed walking with Animal-Stroop task. Results demonstrate that the differences in performance between groups increases as the tasks become harder. These results confirm that premature children when facing a complex environment involving both cognitive and motor tasks will show decrements/adjustments in both tasks. This population is able to perform complex tasks but needs to reallocate their attention to focus on the motor requirements of the task in order to succeed.
Gery, Florence. "Gangliogliome et épilepsie". Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M065.
Pełny tekst źródłaPillet, Pascal. "Syndrome d'activation macrophagique dans les maladies rhumatismales de l'enfant : intérêt de la ciclosporine". Bordeaux 2, 1995. http://www.theses.fr/1995BOR23015.
Pełny tekst źródłaSénéchal, Anne-Marie. "Déficits moteurs mineurs chez les enfants nés très prématurés âgés de 5 ans 9 mois". Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25214/25214.pdf.
Pełny tekst źródłaBarby, Marie-Laure. "Le syndrome de régression caudale chez l'enfant de mère diabétique : données actuelles : à propos d'une observation". Bordeaux 2, 1990. http://www.theses.fr/1990BOR25266.
Pełny tekst źródłaOhnona, Margalith. "Infection fongique systémique chez l'enfant leucémique : étude clinique et évaluation de l'utilisation de l'amphotéricine B liposomale". Paris 5, 1995. http://www.theses.fr/1995PA05P124.
Pełny tekst źródłaLeborgne, Max. "Les glomérulonéphrites aiguës post-streptococciques chez l'enfantbTexte imprimé : données actuelles et étude rétrospective de 30 cas hospitalisés au CHRU de Pointe-à-Pitre (Guadeloupe)". Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M114.
Pełny tekst źródłaMonjauze, Cécile. "Langage et épilepsie à pointes centro-temporales : déficits et séquelles". Tours, 2007. http://www.theses.fr/2007TOUR2028.
Pełny tekst źródłaThe aim of this work was to study the effects of Epilepsy with Centro-Temporal Spikes (ECTS) on language development, in a population of 27 subjects aged 7 to 16. Our results confirm that the prevalence of language impairment associated with ECTS is significantly greater in this population than in an ordinary one, and our longitudinal study supports the hypothesis of long-term effects. Phonology, morphosyntax and written language were the most impaired domains. Morphosyntactic difficulties, the focus of this thesis, were characterized by an avoidance of structures which syntactic theory identifies as complex in French (3rd person accusative clitics, relative clauses). The subjects also produced more morphosyntactic errors, especially in complex syntactic contexts. These results are compatible with a hypothesis of immaturity or impairment of performance systems. A complementary hypothesis of malfunction of the fronto-temporal network is offered as an avenue to explore
Le, Turdu Claudine. "Intérêt de la médecine nucléaire dans le diagnostic en urgence des complications de la drépanocytose chez l'enfant : projet de protocole d'étude en Guadeloupe". Bordeaux 2, 1990. http://www.theses.fr/1990BOR25274.
Pełny tekst źródłaBayle, Laurence. "Encéphalites virales aiguës de l'enfant : étude de l'évolution d'une population de 53 enfants atteints entre 1984 et 1994". Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M142.
Pełny tekst źródłaVersapuech, Julie. "Les hémangiomes périorbitaires : étude de 46 cas". Bordeaux 2, 2000. http://www.theses.fr/2000BOR23046.
Pełny tekst źródłaRech-Billaud, Marianne. "Le syndrome de Kawasaki : à propos de 10 cas : étude rétrospective du 01.01.1987 au 31.12.1996 dans le service de pédiatrie de l'hôpital de Bayonne". Bordeaux 2, 1997. http://www.theses.fr/1997BOR2M143.
Pełny tekst źródłaJabbour, Elie. "Erythroblastopénie aigue à parvovirus B 19 et anémies hémolytiques congénitales : à propos de 3 cas et d'une revue de la littérature". Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M182.
Pełny tekst źródłaLarivière, Thierry. "La bronchiolite folliculaire : à propos d'un cas". Bordeaux 2, 1998. http://www.theses.fr/1998BOR2M095.
Pełny tekst źródłaSallaberry-Watteau, Marion. "Troubles neurologiques congénitaux et roaccutane : à partir de deux observations". Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M107.
Pełny tekst źródłaBittan, Carole. "Impact du G-CSF dans les neutropénies chimio-induite chez les enfants en rechute de leucémies aigue͏̈s lymphoblastiques". Paris 5, 1994. http://www.theses.fr/1994PA05P216.
Pełny tekst źródłaMeillour, Armelle. "Devenir des nouveaux-nés à terme ayant présenté des convulsions néonatales post-anoxiques : étude dans le service de pédiatrie du centre hospitalier de la cote basque sur 12 ans". Bordeaux 2, 1994. http://www.theses.fr/1944BOR2M051.
Pełny tekst źródłaSoussotte, Catherine. "Aspects IRM des tumeurs des voies optiques de l'enfant dans la neurofibromatose de type 1 (NF 1). (Etude comparative en présence ou en l'absence de NF 1)". Bordeaux 2, 1998. http://www.theses.fr/1998BOR23028.
Pełny tekst źródłaNguyen, Thi Quynh Huong. "Insuffisance rénale chronique : épidémiologie de l'insuffisance rénale chronique chez l'enfant à l'Hôpital national pédiatrique de Hanoi et analyse histologique de l'expression du récepteur B1 de la bradykinine sur des biopsies de transplants rénaux". Toulouse 3, 2009. http://thesesups.ups-tlse.fr/918/.
Pełny tekst źródłaThe incidence of end stage renal disease (ESRD) has steadily increased in France and in all developed countries, representing a major public health problem. However, as in most developing countries, epidemiological data on the incidence of chronic kidney disease are greatly lacking in Vietnam, especially in children. The National Paediatric Hospital in Hanoi is a unique centre for treating chronic kidney diseases of all children from northern and central Vietnam. This work has revealed that the incidence of chronic renal failure in children is 5. 1 per million. Children are admitted to hospital very late and the rate of refusal of treatment is very high, especially in families not covered by social security (39% among beneficiaries against 72% among non-beneficiaries). The ESRD patients need replacement therapy, dialysis or transplantation, Kidney transplantation, when possible, is the best treatment for patients with ESRD. But despite the progress and steady improvement in the survival of kidney transplants, most of them develop long-term progressive deterioration of function due to the development and installation of chronic inflammation and interstitial fibrosis. The mechanism of the development of chronic kidney graft is a broad field of research in uro-nephrology. The bradykinin B1-receptor (B1R) is a pro-inflammatory receptor, hardly expressed in physiological conditions and induced in a large variety of tissues during chronic inflammation. The objective of this second part is to study the variation of the B1R expression during the first year following kidney graft by using an immunohistological analysis approach. This work shows that in these patients, the B1R expression is significantly correlated to the rate of creatinine (p <0. 05), the systolic blood pressure (p <0. 05) and finally to interstitial inflammation (p <0. 01). These encouraging results could lead to new therapeutic strategies in chronic allograft nephropathy. This thesis carried out in parallel to the National Paediatric Hospital in Hanoi, Vietnam and INSERM 858 unity, Toulouse, France, focuses on two major fields of kidney failure: epidemiology and physiological mechanisms
Chajes, Muriel. "Le devenir des enfants de mères psychotiques". Bordeaux 2, 1996. http://www.theses.fr/1996BOR23053.
Pełny tekst źródłaFresneau, Brice. "Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant Investigating the Heterogeneity of Alkylating Agents' Efficacy and Toxicity Between Sexes: A Systematic Review and Meta-Analysis of Randomized Trials Comparing Cyclophosphamide and Ifosfamide (MAIAGE Study) Is Alpha-Fetoprotein Decline a Prognostic Factor of Childhood Non-Seminomatous Germ Cell Tumours? Results of the French TGM95 Study New Insight into Severe Ototoxicity after Childhood Cancer. Is there an Impact of Melphalan and Busulfan? A French Childhood Cancer Survivor Study A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated with High-Dose Methotrexate: Data from the OS2006/Sarcoma-09 Trial". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS034.
Pełny tekst źródłaTherapeutic advances in pediatric oncology have improved survival rates reaching over 80%. In order to increase cure rates and decrease complications and treatment sequelae, international collaborative efforts led to the development of therapeutic trials stratified on major prognostic factors including biological factors. However, treatment adaptation to individual patient characteristics remains marginal.In this thesis, our objective was to better understand how somatic (tumor-related) and constitutional (patient-related) characteristics could modify efficacy and toxicity of anticancer therapies used in pediatric oncology. Several works were performed: 1- Prognostic analysis of tumor markers: assessment of the alpha-foetoprotéine (AFP) decline prognostic value in childhood malignant germ cell tumors; 2- Prognostic analysis of constitutional factors: (i) assessment of the interaction between gender and type of alkylating agents on efficacy and acute toxicity; (ii) assessment of the efficacy and toxicity impact of genetic polymorphisms in patients with osteosarcoma treated with high-dose methotrexate; 3- Risk factors analysis of long-term toxicities: analysis of severe ototoxicity in the French Childhood Cancer Survivors Study (FCCSS)
Doger, de Spéville Élodie. "Impact d’une tumeur de la fosse postérieure sur le développement intellectuel et mnésique de l’enfant". Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB017/document.
Pełny tekst źródłaPediatric posterior fossa tumors (PFT) account for two-thirds of all pediatric brain tumors. The most common malignant PFT is medulloblastoma (40%), followed by ependymoma (10%). Surgery, radiotherapy and/or chemotherapy are the current therapeutic approaches. As a result of the progress of treatment, event-free survival has significantly improved. Unfortunately, these children suffer from many cognitive impairments partly attributed to radiotherapy, especially in young children. Alleviating neurocognitive impairments has become one of the major challenges of pediatric oncology. Using an approach combining neuroimaging and neuropsychology, this work examines the relationship between treatments and neuropsychological performances as a function of age in children treated for PFT. The experimental contribution is based on two main axes. The first axis uses an exploratory approach to investigate the relationship between the decline of intellectual functioning and radiation dose distribution. For this purpose, we analyze, with a whole brain analysis, the relation between regional biological dose and changes over time of different cognitive scores (IQ, processing speed and working memory). Our results suggest a positive association between working memory decline and high dose (Equivalent Uniform Dose, EUD) delivered to the orbitofrontal regions, whereas decline of processing speed seems more related to EUD in the temporal lobes and posterior fossa. The 2nd axis uses a hypothesis-driven approach to determine the susceptibility of episodic memory (EM) impairment and hippocampal alteration in young child PFT patients (2-13yo). This part is structured around two aims: First, the assessment of PFT EM performances, thanks to an EM task, in comparison to Controls; second, the exploration of longitudinal patterns of hippocampal volume as a potential neural substrate underlying EM performance. The main results support the evidence of EM impairment in the PFT condition, which varied according to age: in the younger patients (<7yo) impairment was global while in the older it involved only the long term recognition of temporal details (i.e. ‘When’). However, at this stage of the work, several methodological difficulties mainly related to the registration parameters of the segmentation algorithm prevent us from achieving hippocampal volume analysis. This work brings new knowledge about the role of some risk factors on specific cognitive difficulties. Preventing long-term impairments of these children remains a challenge for years to come