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Öberg, Anna, and Charlotta Ruth. "Passing On—The Power of Oral Transmission." Nordic Journal of Dance 14, no. 1 (2023): 116–23. http://dx.doi.org/10.2478/njd-2023-0012.
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Abstract Living Documents is a series of looped live installations developed between 2017 and 2019 based on five artist-choreographers and how they work. The project was initiated by Dominik Grünbühel and Charlotta Ruth as an artistic response to the following research question: What is liveness and what can it be? The research was directed towards the necessity—but also difficulty—of documenting live performances. This text reflects how the method of passing on (in Swedish, tradera) through the collaborative process with choreographer Anna Öberg, whose practice is based in Swedish folk dance, has come to influence the documentary approach. By resonating how passing on in the cosmology of Folk Traditions is different to other methods of physical and oral transfer, Öberg together with Ruth develop how passing on can be valuable beyond the realm of Folk Tradition. Specifically, they unfold the ways in which this multi-sensorial transfer of material and knowledge from person to person and context to context can inspire documentary and reflexive translations between media and different aesthetic realms and thereby contribute to creative ways of sharing knowledge in the field of artistic research.
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Baskerville, Rachel F. "THE TELLING POWER OF CCA — A NEW ZEALAND ORAL HISTORY." Accounting Historians Journal 26, no. 1 (1999): 1–26. http://dx.doi.org/10.2308/0148-4184.26.1.1.
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This report presents results of research on the failure of the inflation accounting standard in New Zealand. Presentation of the results in three narratives highlights that any such research is a series of interlocking and overlapping events, and that narrative is a direct and efficient means of communicating both causal and transactional components which contributed towards the outcomes. Isolation of the three narratives was chosen to demonstrate that it is not useful to extol an explanatory or interpretative paradigm for accounting history if it is advocated at the expense of sequential accounts of events.
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Khan, Nauman Rauf, Hira Khosa, Asma Shakoor, Sameen Zohra, Maria Jabbar, and Hira Butt. "Tissue Ablation Using Lasers: A Case Series." Journal of Health and Rehabilitation Research 4, no. 3 (2024): 1–7. http://dx.doi.org/10.61919/jhrr.v4i3.1220.
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Background: Lasers have recently been discovered as effective treatment modalities in dentistry, offering benefits such as reduced bleeding, infection, treatment and healing durations, and significantly improving patient convenience. They have found a wide range of applications in dentistry, from periodontal therapy to post-extraction healing, allowing for surgical procedures without sutures and minimizing post-operative bleeding by sealing blood vessels. Objective: To evaluate the efficacy of diode laser treatment for tissue ablation in the oral cavity, particularly focusing on cases of excessive gingival growth (gummy smile) and peri-implantitis. Methods: This case series involved two patients: a 19-year-old female undergoing orthodontic treatment with excessive gingival growth and a gummy smile, and a 50-year-old female with peri-implantitis. Both patients were treated using a 980 nm diode laser. Laser parameters included a pulsed operational mode with a frequency of 5 kHz, peak power of 3 W, average power of 1.5 W, and a fiber diameter of 200 µm, with a 50% duty cycle. Data collection involved pre-operative and post-operative clinical examinations, including intraoral photographs, to document gingival overgrowth and treatment outcomes. Post-operative assessments were conducted at regular intervals to evaluate healing, erythema, swelling, and signs of infection. Statistical analysis was performed using SPSS version 25. Results: In the first case, laser treatment reduced gingival overgrowth from 6-7 mm to 0 mm, with no erythema or swelling and minimal pain (VAS score from 4/10 to 1/10). Esthetic improvement was rated as excellent. In the second case, laser treatment resolved gingival overgrowth, eliminated bleeding on probing, and reduced pain (VAS score from 5/10 to 1/10). Implant abutments were clean, with no inflammation. Conclusion: Diode laser therapy is effective for tissue ablation in the oral cavity, ensuring the restoration of esthetics and function. It offers precise tissue removal, reduced post-operative bleeding, and accelerated healing, making it a valuable tool in modern dental practice.
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Shetler, Jan Bender. "The Politics of Publishing Oral Sources from the Mara Region, Tanzania." History in Africa 29 (2002): 413–26. http://dx.doi.org/10.2307/3172172.
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The intense scholarly debate concerning the shift from orality to literacy has not often directly concerned African historians in spite of the fact that many work closely with oral sources. In the process of publishing a series of locally-written histories, I discovered that transforming oral tradition into written form is ultimately political. It raised a number of important ethical dilemmas for me as a scholar and brought to my attention the power relations inherent in these transactions. Oral knowledge and its transformation is not neutral or entirely benevolent. I found out that the change from an oral to a written knowledge base takes power out of the hands of community elders and puts it into the public domain, where literate men have the advantage and where community security may be vulnerable. As scholars we need to face our own involvement in these political processes, even if we cannot ultimately control them.
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Biesbrock, Aaron R., Linda M. Bayuk, Marie-Vee Santana, Darin S. Yates, and Robert D. Bartizek. "The Clinical Effectiveness of a Novel Power Toothbrush and Its Impact on Oral Health." Journal of Contemporary Dental Practice 3, no. 2 (2002): 1–10. http://dx.doi.org/10.5005/jcdp-3-2-1.
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Abstract This review details the invention and clinical testing of a new power toothbrush designed to provide a low cost, effective toothbrush, which has a combination of a round oscillating head in conjunction with fixed bristles. The data demonstrate this power toothbrush (Crest® SpinBrush™) is an effective cleaning toothbrush with respect to plaque removal. Four independent 4-period crossover studies, where subjects used each brush twice, have demonstrated that brushing with this power toothbrush results in 10-40% greater plaque removal relative to a series of control manual toothbrushes. Separate research has confirmed that adults and children tend to brush longer, 35.8% and 38.3% respectively, when using this power toothbrush relative to manual toothbrushes. In addition, it has been shown to be superior to a battery-powered toothbrush (Colgate ActiBrush™) in two independent studies and has demonstrated comparable efficacy to a leading powered toothbrush (Oral-B Ultra Plaque Remover®). In parallel, this power toothbrush has also been shown to be safe relative to manual and power toothbrushes. Citation Biesbrock AR, Bayuk LM, Santana MV, et. al. The Clinical Effectiveness of a Novel Power Toothbrush and Its Impact on Oral Health. J Contemp Dent Pract 2002 May;(3)2: 001-010.
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Rampi, Andrea, Marco Lanzillotta, Gaia Mancuso, Alessandro Vinciguerra, and Lorenzo Dagna. "IgG4-Related Disease of the Oral Cavity. Case Series from a Large Single-Center Cohort of Italian Patients." International Journal of Environmental Research and Public Health 17, no. 21 (2020): 8179. http://dx.doi.org/10.3390/ijerph17218179.
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A series of destructive and tumefactive lesions of the oral cavity are increasingly recognized as part of the IgG4-related disease (IgG4-RD) spectrum. We herein examined the clinical, serological, radiological, and histological features of a series of patients referred to our clinic because of oral cavity lesions ultimately attributed to IgG4-RD. In particular, we studied 6 consecutive patients out of 200 patients referred to the immunology outpatient unit who presented with erosive and/or tumefactive lesions of the oral cavity. All patients underwent serum IgG4 measurement, nasal endoscopy, radiological studies, and histological evaluation of tissue specimens. The histological studies included immunostaining studies to assess the number of IgG4+ plasma cells/High-Power Field (HPF) for calculation of the IgG4+/IgG+ plasma cell ratio. Six patients (3% of the entire cohort) were diagnosed with IgG4-RD of the oral cavity based on histological evaluation. A major complaint at presentation was oral discomfort due to bulging mass. A mild to no increase in serum IgG4 was observed. Different patterns of organ involvement were associated with oral lesions. Five patients were treated with immunosuppressive therapy and two patients promptly responded to B-cell depletion with rituximab. Watchful waiting was decided in one patient with no major clinical symptoms. Involvement of the oral cavity is an infrequent manifestation of IgG4-RD but should be taken into consideration as a possible differential diagnosis of tumefactive or erosive lesions once neoplastic conditions are excluded. A histological examination of biopsy samples from the oral cavity represents the mainstay for diagnosis of IgG4-RD.
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Cavalli, Nicolo, Silvio Taschieri, Clara Carrara, et al. "Non‐surgical treatment protocol of peri‐implantitis with topical doxycycline and air‐polishing with erythritol powder: A case series." Clinical Oral Implants Research 30, S19 (2019): 237. http://dx.doi.org/10.1111/clr.193_13509.
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King, James R., and Norman A. Stahl. "Between word and text in life narratives." Narrative Inquiry 25, no. 1 (2015): 184–202. http://dx.doi.org/10.1075/ni.25.1.11kin.
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The purpose of this essay is to examine the relationships between “the oral” and “the written” in a particular application of narrative research (life rendering research). First, we examine a functional and valuing contrast between oral and written language within oral history methods. Second, we present a critical examination of the use of these linguistic predispositions as they impact life history narratives. Next, we examine a particularly close analogy between oral history and psychiatric patient write-up. Finally, the historical oral/written tension located in oral history practice is located within the frameworks of newer, media-based literacies. The tensions that these intentions create are particularly acute in power-based relationships, such as those between interviewers and informants. Therefore, the organization of the paper is a series of issues that combine to form a critical look at the use of informants’ words in the written narratives of the oral history as a form of discourse synthesis (Spivey, 1997).
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Strate, J., M. A. Cugini, P. R. Warren, J. G. Qaqish, H. J. Galustians, and N. C. Sharma. "A comparison of the plaque removal efficacy of two power toothbrushes: Oral-B Professional Care Series versus Sonicare Elite." International Dental Journal 55, no. 3 (2005): 151–56. http://dx.doi.org/10.1111/j.1875-595x.2005.tb00312.x.
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Liacouras, Chris A., William J. Wenner, Kurt Brown, and Eduardo Ruchelli. "Primary Eosinophilic Esophagitis in Children: Successful Treatment with Oral Corticosteroids." Journal of Pediatric Gastroenterology and Nutrition 26, no. 4 (1998): 380–85. http://dx.doi.org/10.1002/j.1536-4801.1998.tb00803.x.
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ABSTRACTBackground:The histologic appearance of esophageal eosinophils has been correlated with esophagitis and gastroesophageal reflux disease in children. Esophageal eosinophilia that persists despite traditional antireflux therapy may not represent treatment failure, but instead may portray early eosinophilic gastroenteritis or allergic esophagitis. In this study, a series of pediatric patients with severe esophageal eosinophilia who were unresponsive to aggressive antireflux therapy were examined and their clinical and histologic response to oral corticosteroid therapy assessed.Methods:Of 1809 patients evaluated prospectively over 2.5 years for symptoms of gastroesophageal reflux, 20 had persistent symptoms and esophageal eosinophilia, despite aggressive therapy with omeprazole and cisapride. These patients were treated with 1.5 mg/kg oral methylprednisolone per day, divided into twice‐daily doses for 4 weeks. All patients underwent clinical, laboratory, and histologic evaluation before and after treatment.Results:Histologic findings in examination of specimens obtained in pretreatment esophageal biopsies in children with primary eosinophilic esophagitis indicated significantly greater eosinophilia (34.2 ± 9.6 eosinophils/high‐power field [HPF]) compared with that in children with gastroesophageal reflux disease who responded to medical therapy (2.26± 1.16 eosinophils/HPF; p < 0.001). After corticosteroid therapy, all but one patient with primary eosinophilic esophagitis had dramatic clinical improvement, supported by histologic examination (1.5± 0.9 eosinophils/HPF, p < 0.0001).Conclusions:Pediatric patients in a series with marked esophageal eosinophilia and chronic symptoms of gastroesophageal reflux disease unresponsive to aggressive medical antire‐flux therapy had both clinical and histologic improvement after oral corticosteroid therapy.
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Op 't Eijnde, B., M. Van Leemputte, F. Brouns, et al. "No effects of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis." Journal of Applied Physiology 91, no. 5 (2001): 2275–81. http://dx.doi.org/10.1152/jappl.2001.91.5.2275.
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A double-blind randomized study was performed to evaluate the effect of oral ribose supplementation on repeated maximal exercise and ATP recovery after intermittent maximal muscle contractions. Muscle power output was measured during dynamic knee extensions with the right leg on an isokinetic dynamometer before (pretest) and after (posttest) a 6-day training period in conjunction with ribose (R, 4 doses/day at 4 g/dose, n = 10) or placebo (P, n = 9) intake. The exercise protocol consisted of two bouts ( A and B) of maximal contractions, separated by 15 s of rest. Bouts A and B consisted of 15 series of 12 contractions each, separated by a 60-min rest period. During the training period, the subjects performed the same exercise protocol twice per day, with 3–5 h of rest between exercise sessions. Blood samples were collected before and after bouts A and B and 24 h after bout B. Knee-extension power outputs were ∼10% higher in the posttest than in the pretest but were similar between P and R for all contraction series. The exercise increased blood lactate and plasma ammonia concentrations ( P < 0.05), with no significant differences between P and R at any time. After a 6-wk washout period, in a subgroup of subjects ( n = 8), needle-biopsy samples were taken from the vastus lateralis before, immediately after, and 24 h after an exercise bout similar to the pretest. ATP and total adenine nucleotide content were decreased by ∼25 and 20% immediately after and 24 h after exercise in P and R. Oral ribose supplementation with 4-g doses four times a day does not beneficially impact on postexercise muscle ATP recovery and maximal intermittent exercise performance.
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Peng, Dongxiao. "A Method of Improving Oral English Teaching Based on PLS-SEM." Advances in Multimedia 2022 (May 11, 2022): 1–11. http://dx.doi.org/10.1155/2022/6474790.
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To improve the quality of oral English teaching, we must first analyze the factors that affect teaching. Second, it examines the relationship between these factors in order to aid the teaching staff’s oral English instruction and improve the learners’ oral English pronunciation. As a result, determining how to analyze the relationship between various factors in the process of oral English teaching is a problem that is still being worked on. In response to this issue, this paper proposes a partial least squares-structural equation modeling (PLS-SEM) method for improving oral English teaching. The central idea of this method is to first analyze and summarize all relevant factors affecting oral English teaching as thoroughly as possible. Second, the influencing factors are quantified into specific numerical data, and the data are subjected to a series of preprocessing steps. Third, the PLS-SEM model is trained, and the preprocessed data are fed into the statistical analysis. Finally, the relationship between the factors is summarized based on the statistical analysis results. This paper evaluates the PLS-SEM model in terms of reliability and validity in order to validate the effectiveness of the method used. The PLS-SEM model developed in this paper for improving oral English teaching has high reliability, validity, and explanatory power. This method-based oral English teaching strategy can improve students’ oral English levels and has a high practical application value.
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Ucherek, Dorota. "Magiczno-religijna mozaika. Źródła obrazów postaci bogów Krain Wewnętrznego Morza z „Sagi o Zbóju Twardokęsku” Anny Brzezińskiej." Literatura i Kultura Popularna 27 (December 29, 2021): 213–45. http://dx.doi.org/10.19195/0867-7441.27.16.
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The aim of this article is to find the sources of images of the Inner Sea Lands gods in Anna Brzezińska’s “Saga of Twardokęsek the Brigand”. The author presents the most important features of these characters, their most recognizable actions and attributes, comparing them with possible prototypes derived from Greek, Roman, Scandinavian, Slavic, and Hindu mythology, as well as Christianity. She points out that the gods in Brzezińska’s saga, although worshipped, are not omnipotent and do not possess full creative powers. They turn out to be only slightly more powerful than their off spring, the fruit of their relationships with humans — witches. Shaping human fates, they are only able to recreate ancient patterns over and over again and are subject to a higher power (similarly to how the Greek gods were subject to Fatum). In their images, we can also find traces of inspiration from the classic mythopoetic fantasy, especially Ursula K. Le Guin’s series about the Earthsea. Thus, these images can be seen as a magical-religious mosaic, which evokes associations with the considerations of classical anthropology on the relations between magic and religion. The author also puts forward the hypothesis about treating these images as a metaphor for the process of creating literature, especially in its original, oral form.
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Batista, Patrícia, Pedro Miguel Rodrigues, Miguel Ferreira, et al. "Validation of Psychophysiological Measures for Caffeine Oral Films Characterization by Machine Learning Approaches." Bioengineering 9, no. 3 (2022): 114. http://dx.doi.org/10.3390/bioengineering9030114.
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(1) Background: The oral films are a new delivery system that can carry several molecules, such as neuromodulator molecules, including caffeine. These delivery systems have been developed and characterized by pharmacokinetics assays. However, new methodologies, such as psychophysiological measures, can complement their characterization. This study presents a new protocol with psychophysiological parameters to characterize the oral film delivery systems based on a caffeine model. (2) Methods: Thirteen volunteers (61.5% females and 38.5% males) consumed caffeine oral films and placebo oral films (in different moments and without knowing the product). Electrocardiogram (ECG), electrodermal (EDA), and respiratory frequency (RF) data were monitored for 45 min. For the data analysis, the MATLAB environment was used to develop the analysis program. The ECG, EDA, and RF signals were digitally filtered and processed, using a windowing process, for feature extraction and an energy mean value for 5 min segments. Then, the data were computed and presented to the entries of a set of Machine Learning algorithms. Finally, a data statistical analysis was carried out using SPSS. (3) Results: Compared with placebo, caffeine oral films led to a significant increase in power energy in the signal spectrum of heart rate, skin conductance, and respiratory activity. In addition, the ECG time-series power energy activity revealed a better capacity to detect caffeine activity over time than the other physiological modalities. There was no significant change for the female or male gender. (4) Conclusions: The protocol developed, and the psychophysiological methodology used to characterize the delivery system profile were efficient to characterize the drug delivery profile of the caffeine. This is a non-invasive, cheap, and easy method to apply, can be used to determine the neuromodulator drugs delivery profile, and can be implemented in the future.
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Rajkumar, R., Dınesh Valluru, Siva Satya Sreedhar .., et al. "Enhanced Jaya Optimization Algorithm with Deep Learning Assisted Oral Cancer Diagnosis on IoT Healthcare Systems." Journal of Intelligent Systems and Internet of Things 11, no. 2 (2024): 97–110. http://dx.doi.org/10.54216/jisiot.110209.
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Recently, healthcare systems integrate the power of deep learning (DL) models with the connectivity and data processing capabilities of the Internet of Things (IoT) to enhance the early recognition and diagnosis of disease. Oral cancer diagnosis comprises the detection of cancerous or pre-cancerous abrasions in the oral cavity. Timely identification is essential for successful treatment and enhanced prognosis. Here is an overview of the key aspects of oral cancer diagnosis. One potential benefit of utilizing DL for oral cancer detection is that it analyses huge counts of data fast and accurately, and it could not need clear programming of the rules for recognizing abnormalities. This can create the procedure of detecting oral cancer more effective and efficient. Thus, the study presents an Enhanced Jaya Optimization Algorithm with Deep Learning Based Oral Cancer Classification (EJOADL-OCC) method. The presented EJOADL-OCC method aims to classify and detect the existence of oral cancer accurately and effectively. To accomplish this, the presented EJOADL-OCC method initially exploits median filtering for the noise elimination. Next, the feature vector generation process is performed by the residual network (ResNetv2) model with EJOA as a hyperparameter optimizer. For accurate classification of oral cancer, a continuously restricted Boltzmann machine with a deep belief network (CRBM-DBN) model. The simulated validation of the EJOADL-OCC algorithm is tested by the series of simulations and the outcome demonstrates its supremacy over present DL approaches.
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Sadalova, Tamara. "Altaian Folklore Motifs about Shunu-Batyr." Бюллетень Калмыцкого научного центра Российской академии наук 3, no. 23 (2022): 109–19. http://dx.doi.org/10.22162/2587-6503-2022-3-23-109-119.
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Introduction. The article analyzes folklore motifs of Altaian historical legends associated with the name of the famous historical figure — ShunuBatyr. The study proves topical enough since texts of historical legends in the Altaian oral tradition tend to reflect actual historical events, and thus are of particular interest. Goals. The article aims to examine texts of Altaian legends about Shunu-Batyr from the perspective of folklore historicism manifested therein. Materials and methods. The paper deals with samples of oral narratives recorded at different times. The employed research methods include the comparative/historical and comparative/descriptive ones. Results. The work reveals that a characteristic feature of the considered legends is a fairly high degree of ‘historicity’ manifested both in the character proper that has a real historical prototype, and in plot episodes associated with certain historical events. The legends of Shunu-Batyr summarize a series of conflicts pertaining to a specific historical event — struggle for power in the Dzungar Khanate. Our analysis reveals that the historicity of Altaian legends proves reliable enough, though events of the past tend to be interpreted in oral texts through traditional views and representations inherent to Altaian folklore.
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Cooper, B., M. Ahlquist, R. M. Friedman, B. Loughner, and M. Heft. "Properties of high-threshold mechanoreceptors in the oral mucosa. I. Responses to dynamic and static pressure." Journal of Neurophysiology 66, no. 4 (1991): 1272–79. http://dx.doi.org/10.1152/jn.1991.66.4.1272.
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1. Mechanical response properties of high-threshold mechanoreceptors (HTMs) of the goat oral mucosa were determined by single-unit recording from the palatine and alveolar nerves and from the trigeminal ganglion. The following observations were made. 2. HTMs of the oral mucosa could be separated into two subgroups on the basis of their threshold to mechanical stimulation. Intense pressure receptors (IPRs) comprised a group of A-delta afferents with thresholds of 2-16 g. Mechanonociceptors (MNs) comprised a group of relatively slowly conducting afferents (A-delta and C-fibers) with a higher threshold range (16-300 g). 3. In most instances, MNs lacked pressure-transducing capacity. Tests of reactivity to dynamically or statically applied stimuli revealed that significant functions were rarely fit between MN activity and pressure (4/20 cases). 4. IPRs differed from MNs by their pressure-transducing properties. The afferent response interval was in inverse proportion to the applied pressure. Significant pressure interval functions were fit in 16/20 cases. The relationship between pressure and response interval was best described by power functions. 5. Tests of reactivity to dynamically or statically applied stimuli revealed that IPRs preferred static pressure. Tighter fits and steeper slopes were observed in power functions fit to data generated by statically applied stimuli (mean fitted function, dynamic test: LnISI = -0.97 LnP + 3.4; mean fitted function, static test: LnISI = -1.6 LnP + 4.71). 6. Pressures-frequency thresholds (PFTs), asymptotes (PFAs), and mean response intervals (MRIs) were determined for IPRs from the static test series. The first two values are the pressures that produce the lower and upper limits of response frequency of mucosal HTMs (mean PFT, 1.48 N/mm2; mean PFA, 3.34 N/mm2). The MRI (28 ms) is simply computed from the function. When PFTs and PFAs are combined with activation threshold and power functions, they provide a relatively complete description of the range and form of reactivity of the IPR of the oral mucosa.
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Cherniak, Olha, Lilia Savchuk, Oksana Ripolovska, et al. "Ultrasonographic Identification of the Parotid Cystadenolymphoma (Warthin’s Tumor) by Oral and Maxillofacial Surgeons: Supplement to the Matsuda and Colleagues’ Classification." Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology 6, no. 7 (2022): 92–110. http://dx.doi.org/10.23999/j.dtomp.2022.7.1.
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Warthin’s tumor (WT), which is also known as papillary cystadenoma lymphomatosum, monomorphic parotid adenoma, adenolymphoma, cystadenolymphoma, and branchiogenic adenoma, is to be differentiated (in surgical practice) from other parotid masses. The purposes of our retrospective case series study are: (1) to describe ultrasound morphology (sonomorphology) of the WT in patients referred to our hospital, (2) based on the presented cases to propose a supplement to the Matsuda and colleagues’ classification (2017) of anechoic area patterns of the WT, and (3) to expand the knowledge of oral and maxillofacial surgeons for the preoperative ultrasonographic verification of the WT and for choosing the most appropriate surgical technique. Over three years, 5 patients (mean age, 65.4 years) with parotid WT had been examined with gray-scale, color, and power Doppler ultrasonography. Cystic components are visualized in all five WT cases but in different proportions. Case 1 and 4 showed the presence of septations. According to Matsuda and colleagues’ (2017) classification of anechoic area patterns, in our cases the US patterns of the WTs belong only to Group 3 (i.e., with large anechoic areas) (n = 4) and Group 4 (multiple and sponge-like anechoic areas) (n = 1). Moreover, based on the presented five cases, we offer an addition to the classification of Japanese authors. In conclusion, our supplement to Matsuda and colleagues’ classification of anechoic area patterns of the WT can help surgeons around the globe to be more accurate in preoperative verification of cystadenolymphoma. This case series illustrate the growing importance of ultrasonography in the professional life of oral and maxillofacial and head and neck surgeons. Based on the cystic structure of this benign tumor and the ultrasound appearance presented in our case series, we propose to continue using the term “cystadenolymphoma” with a purpose to emphasize the tumor`s structure.
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Heintze, Beatrix. "Afrika-Archiv: A New Series of the Frobenius Institute for the Purpose of Publishing Source Material." History in Africa 24 (January 1997): 437–39. http://dx.doi.org/10.2307/3172045.
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“[D]as Wirkungsvolle wird gepflegt, die Gewissenhaftigkeit schwindet; an Stelle der Fähigkeit zu bergründen, der Kraft zu überzeugen, tritt die Sicherheìt im Behaupten.”[T]hat what impresses is cultivated, conscientiousness dwindles; the capability to explain, the power to convince are replaced by self-confidence in asserting.There is nothing more absurd—yet also nothing more common—than a scholarly lifetime of publishing based on materials to which no one else has access.The series “Afrika Archiv” (“Africa Archives”) was founded recently with the aim of publishing source material referring to the history and anthropology of Africa. In this connection the term “source material” shall be considered in a very broad sense. Thus, beside the usual library and other written sources, as well as written records of oral traditions, for instance, even editions of ethnographic collections or photographic documentation will be taken into consideration. African scholars will be able to publish material from their own countries to which we Europeans and Americans have only difficult access. Western scholars, on the other hand, could publish sources from public and private European or American archives, museums, or even widely dispersed articles in periodicals and newspapers on African history of the nineteenth century which are available only with great difficulty and expenditure of time. As a reviewer once commented, such source editions will still continue to be valued when contemporary interpretations have already long fallen into oblivion.Endeavors to record systematically varied sources on the history of the continent, the cultural and scientific history of Africa, and to make the essentials generally available to the scientific public still appear inadequate.
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Zhang, Hao, Zhenxia Xu, Zhixian Qiao, et al. "Encapsulation of Functional Plant Oil by Spray Drying: Physicochemical Characterization and Enhanced Anti-Colitis Activity." Foods 11, no. 19 (2022): 2993. http://dx.doi.org/10.3390/foods11192993.
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In this study, an encapsulation system was developed for functional plant oil delivery. Through a series of orthogonal experiments and single factor experiments, the raw material compositions, emulsification conditions, and spray drying conditions for the preparation of flaxseed oil and safflower seed oil powders were optimized, and the final encapsulation efficiency was as high as 99% with approximately 50% oil loading. The storage stability experiments showed that oil powder’s stability could maintain its physicochemical properties over six months. Oral supplementation of the spray-dried flaxseed oil powder exhibited a significant and better effect than flaxseed oil on alleviating colitis in C57BL/6J mice. It suppressed the pro-inflammatory cell factors, including IL-6 and TNF-α, and repaired gut microbial dysbiosis by increasing the microbial diversity and promoting the proliferation of probiotic taxa such as Allobaculum. This work suggests that spray-dried flaxseed oil powder has great potential as a nutraceutical food, with spray drying being a good alternative technique to improve its bioactivity.
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Kerrigan, William. "Collecting Stories About Strip-Mining." Teaching History: A Journal of Methods 28, no. 1 (2003): 22–28. http://dx.doi.org/10.33043/th.28.1.22-28.
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The study of history has always been an interdisciplinary exercise that borrows generously from the methods and insights provided by other disciplines, but the narrative method continues to remain central to the discipline of history. Telling stories as a method of explaining how things have changed or why things are the way they are is at the heart of most historical endeavors. Despite the centrality of story-telling-to the discipline of history, until relatively recently, historians have given little critical consideration to the narrative as a method of explanation, and non-historians, our students among them, even less so. Most of the students in my classroom enter with the understanding that history is merely a series of stories, and that stories are merely a collection of facts. It is important, however, to make students of history aware that the narrative is a method of explanation, that story-telling is not merely the process of ordering a series of facts. One of the most valuable lessons students of history can learn, I believe, is that narratives can be constructed in ways that will lead different storytellers ( and their audiences) to quite different conclusions. The use of oral history in the classroom can be an effective method to help students understand the power of the narrative.
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Noudelmann, Francois. "Philosophical Aurality." PMLA/Publications of the Modern Language Association of America 135, no. 2 (2020): 412–18. http://dx.doi.org/10.1632/pmla.2020.135.2.412.
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The Notion of Aurality, by Going Beyond the Usual Distinction Between Written and Oral Language, Raises Questions About the nature of listening while reading. The academic rehabilitation of orality in relation to writing has certainly made way for audible performing arts. It has also led to reassessments of cultures in all continents and archipelagoes that favor oral transmission. However, this attention to the auditory should not cause us to forget an orality inside writing, which comes not only from its inspiration but also from its very material. Let us therefore follow Friedrich Nietzsche's injunction to remove the plugs from our ears (332) and forget the legend of ideas being silent, abstracted from any sonic reality. Even if we do not use the expression “oral philosophy,” we must remember that many discourses since antiquity, especially those of Socrates, have been oral performances. Our reading of ancient philosophy should therefore be sensitive to this acoustic dimension. But Western philosophy has constantly been suspicious of hearing, probably because the ear is always suspected of passivity, compared to an eye that objectifies reality. Since the ears have no lids to interrupt perception, they allow the sonic matter of the world to pass through without the subject's being able to control it. Consequently, the history of metaphysics presents a series of interdictions against sounds, and warnings about their enchanting power and their betrayal of the meaning they are supposed to carry. The desire to channel and domesticate the anarchy of sounds reflects a philosophical malentendu: sound is both misheard and misunderstood.
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Cotomacio, Claudia Carrara, Luana Campos, and Fabiana Martins. "The oral manifestations of scurvy in the 21st century." Research, Society and Development 10, no. 12 (2021): e344101220569. http://dx.doi.org/10.33448/rsd-v10i12.20569.
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Scurvy is a vitamin deficiency historically associated with pirates and sailors that affects collagen synthesis, leading to hemorrhage, skin, and oral lesions. In the 18th century, the lack of consumption of foods rich in vitamin C was found to cause such a severe condition, whose early diagnosis increases the likelihood of a better prognosis. A 58-year-old female patient complained of fatigue, body pain, and gingival bleeding for nearly 24 months. In 2001, she was diagnosed with lupus, now in remission, and osteoporosis more recently. On clinical examination, gingivitis with spontaneous bleeding was observed, despite the patient’s good hygiene, as well as some petechiae over the body. Due to the hypothesis of a possible autoimmune dermatological disease, the patient was referred to a dermatologist, who requested a series of tests, including vitamin C dosage. The results showed a concentration below 0.25mg / dL (IR, 4 to 2.0 mg / dL), and thus the diagnosis of scurvy was established. The patient was administered vitamin C replacement and in about 3 months, the symptoms started to improve. In some cases, such as this, hospitalization is required for intravenous replacement due to bleeding risks. This case report highlights the importance of the dentist in the early diagnosis and treatment of scurvy. This condition causes oral lesions that are often confused with other more common conditions, such as gingivitis or autoimmune dermatological response. Therefore, we recommend a comprehensive physical examination and anamnesis, including dietary history.
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Wahyudi, Risqi, Afnan Septi Mulyani, Alfi Nur Ramadhani, et al. "EDUKASI MENYIKAT GIGI DENGAN BENAR SEBAGAI UPAYA PENCEGAHAN GIGI BERLUBANG (KARIES) PADA MURID SD NEGERI 4 SUREN KABUPATEN JEMBER." BERNAS: Jurnal Pengabdian Kepada Masyarakat 3, no. 4 (2022): 526–32. http://dx.doi.org/10.31949/jb.v3i4.3255.
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Brushing teeth is the easiest way to maintain dental and oral health. Elementary school age children have a susceptibility to problems with teeth and mouth. Risk factors that are still driving the high prevalence of dental cavities (caries) in children include: incorrect brushing techniques; inappropriate brushing time and frequency; intake of cariogenic food and drink; low supervision from parents; and the lack of knowledge of children on how to maintain dental and oral health. The problem of cavities in children interferes with the growth and development and attendance of children at school. The purpose of the study: to improve the knowledge and skills of students at SD Negeri 4 Suren on how to brush their teeth properly. Research method: the activity was carried out offline at SD Negeri 4 Suren, on Saturday, August 20, 2022. A series of counseling activities included licensing to the principal of SD Negeri 4 Suren, giving a tooth brushing practice pretest, delivering material verbally assisted by poster media, material in in the form of power points, educational videos, followed by a demonstration of phantom teeth followed by hands-on practice, and giving posttest. Results and conclusions: The pretest results showed 2 out of 10 students answered correctly, while the posttest results showed all students answered the questions correctly. This shows that counseling activities increase students' insight into
 dental and oral health.
 Keywords: dental health; caries; Suren Village
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CHENG, Hua, Linling LI, Juan HUA, Honghui YUAN, and Shuiyuan CHENG. "A Preliminary Preparation of Endophytic Bacteria CE3 Wettable Powder for Biological Control of Postharvest Diseases." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 43, no. 1 (2015): 159–64. http://dx.doi.org/10.15835/nbha4319699.
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Recently, there has been an increasing interest among researchers in using combinations of biological control agents to exploit potential synergistic effects among them. In the present study, there were investigated commercially acceptable formulations of Bacillus cereus CE3 wetting powder with long storage life and retained efficacy to control chestnut and other fruit rot caused by Endothia parasitica (Murr) and Fusarium solani. The study sought to develop a new B. cereus formulation that would be more effective and better suited to the conditions of field application. By a series of experiments, the formulation was confirmed as follows: 60% B. cereus freeze-dried powder, 28.9% diatomite as carrier, 4% sodium lignin sulfonate as disperser, 6% alkyl naphthalene sulfonate as wetting agent, 1% K2HPO4 as stabilizer, 0.1% β-cyclodextrin as ultraviolet protectant. The controlling experiments showed that the diluted 100 times of 60% B. cereus wetting powder had 79.47% corrosion rate to chestnut pathogens; and this result is comparable to the diluted 1,000 times of 70% thiophanate-methyl. Safety evaluation results showed that rats acute oral lethal dose 50% was 5,000.35, therefore application of B. cereus wettable powder could not cause a person or animal poisoning. This work illustrated that 60% B. cereus wetting powder had commercial potential; however, to apply this formulation as a biological pesticide in the field, masses production processes need to be further studied.
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Sett, Alisha. "Photo Circle: A Short History of the Nepal Picture Library." Cabinet, Vol. 2, no. 2 (2017): 56–69. http://dx.doi.org/10.47659/m3.056.art.
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This is a short history of the Nepal Picture Library (NPL), Nepal’s first large-scale digital photo archive encompassing over 50,000 photographs collected in less than a decade. It is a rare institution; a catalogued visual resource open to the public with scores of intimate family collections, the historic and the mundane captured over decades by photojournalists, and portraits made in photo studios across the country. The essay provides insight into the strength, scope and potential of this community-created archive. Founded and managed by Photo Circle, a platform for photography in Kathmandu, NPL has published books, done several exhibitions in museums and public spaces across Nepal, and exhibited their collections internationally. Tracing the origins and the impact of NPL through a series of interviews, the essays reveals not only the transformative power of their methods of public engagement but also the deep concern for visual culture fostered in their volunteers particularly among photographers serving as amateur archivists. Keywords: archive, Kathmandu, Nepal, oral history, public history
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Feldman, Leah. "Reading Gogol’ in Azeri: Parodic Genealogies and the Revolutionary Geopoetics of 1905." Slavic Review 75, no. 2 (2016): 256–78. http://dx.doi.org/10.5612/slavicreview.75.2.256.
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AbstractThis essay investigates the geopoetic strategies through which Muslim writers contributed to as well as undermined the consolidation of the Russian literary canon. Its central focus is the Azeri writer Celil Memmedquluzade’s translation of Gogol’’s work, revealing the politicization of Gogol”s poetics in the Muslim south Caucasus in 1905. Drawing upon Gogol’’s prose about the Russian provinces, its translation in the Caucasus, and its resurrection in literary theory, I illustrate the ways in which the poetics of the imperial provinces intersected with the Russian and Soviet imperial gaze, highlighting the internalizing force of imperial expansion as well as the radical alterity of the colonial experience. The early twentieth century was marked by a series of revolutionary upheavals in the imperial capital and periphery, as well as a Bolshevik ideological campaign to envision literature as an enlightened enterprise, that is, one characterized by both its scientific and political power. In dialectical fashion, the creation of a revolutionary poetics involved a repetition of Gogol’’s prose in order to reconcile and thus transcend the series of binaries associated with nineteenth century literature: center/periphery, oral/written, self/other. Gogol’’s resurrection in Memmedquluzade’s translations and in the hands of his Formalist and postcolonial critics highlights the role of Russian imperial geopoetics in simultaneously sustaining and subverting a revolutionary literary culture
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Sharpless, Katherine E., David L. Anderson, Joseph M. Betz, et al. "Preparation and Characterization of a Suite of Ephedra-Containing Standard Reference Materials." Journal of AOAC INTERNATIONAL 89, no. 6 (2006): 1483–95. http://dx.doi.org/10.1093/jaoac/89.6.1483.
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Abstract The National Institute of Standards and Technology, the U.S. Food and Drug Administration, Center for Drug Evaluation and Research and Center for Food Safety and Applied Nutrition, and the National Institutes of Health, Office of Dietary Supplements, are collaborating to produce a series of Standard Reference Materials (SRMs) for dietary supplements. A suite of ephedra materials is the first in the series, and this paper describes the acquisition, preparation, and value assignment of these materials: SRMs 3240 Ephedra sinica Stapf Aerial Parts, 3241 E. sinica Stapf Native Extract, 3242 E. sinica Stapf Commercial Extract, 3243 Ephedra-Containing Solid Oral Dosage Form, and 3244 Ephedra-Containing Protein Powder. Values are assigned for ephedrine alkaloids and toxic elements in all 5 materials. Values are assigned for other analytes (e.g., caffeine, nutrient elements, proximates, etc.) in some of the materials, as appropriate. Materials in this suite of SRMs are intended for use as primary control materials when values are assigned to in-house (secondary) control materials and for validation of analytical methods for the measurement of alkaloids, toxic elements, and, in the case of SRM 3244, nutrients in similar materials.
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Lauritano, Dorina, Alberta Lucchese, Federica Gabrione, Dario Di Stasio, Javier Silvestre Rangil, and Francesco Carinci. "The Effectiveness of Laser-Assisted Surgical Excision of Leukoplakias and Hyperkeratosis of Oral Mucosa: A Case Series in A Group of Patients." International Journal of Environmental Research and Public Health 16, no. 2 (2019): 210. http://dx.doi.org/10.3390/ijerph16020210.
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Introduction: In the different branches of dentistry, the use of laser to solve different clinical situations is increasing due to numerous advantages that have been studied in literature since the 70s. Leucoplakia and hyperkeratosis can benefit from laser-assisted treatment. In most cases biopsy sampling, histological examination and, if no malignant cells are present, the follow-up is needed. However, even if the lesion is free of dysplasia patients often ask to eliminate these white spots that are always a cause of concern. Aim: From these numerous requests comes the idea of setting up a laser-assisted protocol as less invasive as possible to be offered to patients. The aim of the study is to find a laser-assisted protocol for the surgical excision of leucoplakia and hyperkeratosis that can both improve the clinical aspect of the lesion and be sustainable for patients. The null hypothesis has been identified in the following statement: the treatment is effective and efficient at the same time; where effectiveness was tested with the following criteria: size of the lesion, tactile perception, discomfort, pain; and efficiency with the following criteria: pain and discomfort perceived during the treatment. Materials and methods: To collect all data, a specially designed medical record was used. The diode laser was used with a pulsed mode and the maximum power corresponds to 1.8 W. No anaesthesia was used. Before laser-assisted treatment, the fibre was activated and was used with a contact overflowing. Results: Our results show a decrease in the size of the lesion statistically significant. No pain was referred during treatment, except for a slight burning sensation. Conclusion: In conclusion we can state that the treatment is both efficient and effective.
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Fusco, Roberta, Angela Trovato Salinaro, Rosalba Siracusa, et al. "Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model." Antioxidants 10, no. 5 (2021): 778. http://dx.doi.org/10.3390/antiox10050778.
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Background: Every year, men use cyclophosphamide to treat various cancers and autoimmune diseases. On the one hand, this chemotherapy often has the beneficial effect of regressing the tumor, but on the other hand, it leads to infertility due to excessive oxidative stress and apoptosis in the testes caused by its metabolite, acrolein. Methods: The objective of this study was to evaluate the beneficial power of a new compound called Hidrox®, containing 40–50% hydroxytyrosol, in counteracting the damage related to fertility induced by cyclophosphamide. The study was conducted using a single intraperitoneal injection of cyclophosphamide at a dose of 200 mg/kg b.w, in distilled water at 10 mL/kg b.w. The treatment was administered via the oral administration of Hidrox® at a dose of 50 mg/kg. Results: Our study confirms that the use of cyclophosphamide causes a series of sperm and histological alterations strongly connected with oxidative stress, lipid peroxidation, and apoptosis. Conclusion: Our results demonstrate for the first time that Hidrox® protects testes from CYP-induced alterations by the modulation of physiological antioxidant defenses.
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Thomas, Jeanice B., Katherine E. Sharpless, Staci Mitvalsky, Mark Roman, James Yen, and Mary B. Satterfield. "Determination of Caffeine and Caffeine-Related Metabolites in Ephedra-Containing Standard Reference Materials Using Liquid Chromatography with Absorbance Detection and Tandem Mass Spectrometry." Journal of AOAC INTERNATIONAL 90, no. 4 (2007): 934–40. http://dx.doi.org/10.1093/jaoac/90.4.934.
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Abstract The concentrations of caffeine and caffeine-related compounds in 2 ephedra-containing reference materials have been determined by 3 independent methods with measurements performed by the National Institute of Standards and Technology (NIST) and a collaborating laboratory. Results from the 3 methods were used for value assignment of caffeine, theobromine, and theophylline in these Standard Reference Materials (SRMs). The methods used at NIST to determine the concentration levels of caffeine, theobromine, and theophylline in SRM 3243 Ephedra-Containing Solid Oral Dosage Form and SRM 3244 Ephedra-Containing Protein Powder used reversed-phase liquid chromatography with absorbance detection and tandem mass spectrometry. These reference materials are part of the first suite in a series of NIST SRMs that provide concentration values for multiple components in dietary supplements. These SRMs are primarily intended for method validation and for use as control materials to support the analysis of dietary supplements and similar materials.
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Michel, Raphaella Coelho, Rafael Ferreira, Erika Beatriz Spada de Carvalho, et al. "Xenogeneic collagen matrix for the treatment of multiple gingival recessions in esthetics areas: a case series with 24-month follow-up." Research, Society and Development 10, no. 10 (2021): e349101018776. http://dx.doi.org/10.33448/rsd-v10i10.18776.
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Introduction: Multiple gingival recessions (GR) are often associated with high hypersensitivity and esthetics concerns due to exposed roots. The collagen matrix (CM) associated with coronally advanced flap (CAF) may be a suitable treatment for multiple GR in esthetic areas. However, there is a lack of long term follow up investigations. Objective: To evaluate a 24-month follow-up of the CM + CAF treatment for multiple RT1 GRs in esthetics areas. Materials and Methods: Six patients presenting 6 adjacent Cairo’s gingival recessions type 1 (RT1) in the anterior maxilla were treated with CM + CAF, and based on these patients a brief statistical analysis was conduct. The evaluated parameters included gingival recession depth (GRD), gingival recession width (GRW), probing depth (PD), clinical attachment level (CAL), keratinized tissue width (KTW), gingival thickness (GT), and mean root coverage (MRC). Patient-related outcomes measurements (PROMs) were assessed using an oral health impact profile (OHIP-14) questionnaire and visual analogue scale (VAS). Results: There was significant improvement in GRD, GRW, and CAL measurements at 3 months postoperatively (p<0.05). Besides, CAL also increased from 12 months to 24 months’ follow-up (p=0.0023). The MRC percentage was 82%. PD, GT, and KTW presented no statistical difference. PROMs revealed a high score for esthetics (82.2%) and a significant reduction in hypersensitivity and surgical pain/discomfort. Conclusions: Considering the limitations of a case series, the use of CM + CAF on RT1 multiple gingival recessions in esthetic areas demonstrated positive outcomes after 24 months.
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Aquino, Rita P., Giulia Auriemma, Giulio M. Conte, et al. "Development of Chitosan/Mannitol Microparticles as Delivery System for the Oral Administration of a Spirulina Bioactive Peptide Extract." Molecules 25, no. 9 (2020): 2086. http://dx.doi.org/10.3390/molecules25092086.
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Spirulina platensis contains several compounds showing nutritional and therapeutic benefits. Recently, a series of peptides able to reduce the blood pressure level and to enhance the endothelial vasorelaxation was isolated from the hydrolyzed highly water-soluble Spirulina extract (HSE). However, HSE shows critical organoleptic characteristics also having poor intestinal permeability, limiting absorption when orally delivered. This research aims to overcome the critical issues through the encapsulation of HSE in Chitosan/Mannitol—(CM)-based microparticles by spray drying. The produced powders (CM-HSE) showed good process yield (≈70%) and encapsulation efficiency (≈100%) also having good derived flow properties as well as stability up to six months storage. The microparticles constituting the spray-dried powder resulted in an amorphous micrometric state (d50 ≈ 14 µm) able to retain dark colour and unpleasant smell of raw HSE. Moreover, the in vitro permeation study by Franz cell indicated that the engineered microparticles are able to enhance the permeation of HSE through an intestinal biomimetic barrier (551.13 μg/cm2 CM-HSE vs. 315.46 μg/cm2 HSE at 270 min).
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Stilwell, Sean, Ibrahim Hamza, and Paul E. Lovejoy. "The Oral History of Royal Slavery in the Sokoto Caliphate: An Interview with Sallama Dako." History in Africa 28 (2001): 273–91. http://dx.doi.org/10.2307/3172218.
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A powerful community of royal slaves emerged in Kano Emirate in the wake of Usman dan Fodio's jihad (1804-08), which established the Sokoto Caliphate. These elite slaves held administrative and military positions of great power, and over the course of the nineteenth century played an increasing prominent role in the political, economic, and social life of Kano. However, the individuals who occupied slave offices have largely been rendered silent by the extant historical record. They seldom appear in written sources from the period, and then usually only in passing. Likewise, certain officials and offices are mentioned in official sources from the colonial period, but only in the context of broader colonial concerns and policies, usually related to issues about taxation and the proper structure of indirect rule.As the following interview demonstrates, the collection and interpretation of oral sources can help to fill these silences. By listening to the words and histories of the descendents of royal slaves, as well as current royal slave titleholders, we can begin to reconstruct the social history of nineteenth-century royal slave society, including the nature of slave labor and work, the organization the vast plantation system that surrounded Kano, and the ideology and culture of royal slaves themselves.The interview is but one example of a series of interviews conducted with current and past members of this royal slave hierarchy by Yusufu Yunusa. As discussed below, Sallama Dako belonged to the royal slave palace community in Kano. By royal slave, we mean highly privileged and powerful slaves who were owned by the emir, known in Hausa as bayin sarki (slaves of the emir or king).
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Nascimento, Juliana de Souza do, Alcides Ricardo Gonçalves, Miqueias Martins Lima Silva, et al. "Photodynamic therapy and Photobiomodulation as adjuvant treatment of oral and facial manifestations in patients with COVID-19 hospitalized in the intensive care unit: a case series." Research, Society and Development 11, no. 12 (2022): e32111233833. http://dx.doi.org/10.33448/rsd-v11i12.33833.
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Orofacial injuries resulting from Coronavirus-19 (COVID-19) are reported in the current literature. The etiology of these manifestations is still unknown, but them seem to have an association between the prone position and patient’s immunosuppression. Clinical features range from nonspecific ulcers to vesicles that may mimic viral infections. The search for a clinical protocol for the cure of these lesions is necessary. Thus, some studies about photobiomodulation, a low-level light therapy with regenerative tissue action, associated with antimicrobial photodynamic therapy, as a promising adjuvant treatment. Therefore, the present study aims to report a series of cases where photobiomodulation and photodynamic therapy were used in patients positive for COVID-19 and presented orofacial lesions during the time of hospitalization in the intensive care unit. In all cases, tissue regeneration was complete, demonstrating the effectiveness of photobiomodulation and photodynamic therapy as adjuvant therapy associated with the use of medicines.
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Beis, Lukas, Yaser Mohammad, Chris Easton та Yannis P. Pitsiladis. "Failure of Glycine-Arginine-α-Ketoisocaproic Acid to Improve High-Intensity Exercise Performance in Trained Cyclists". International Journal of Sport Nutrition and Exercise Metabolism 21, № 1 (2011): 33–39. http://dx.doi.org/10.1123/ijsnem.21.1.33.
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Oral supplementation with glycine-arginine-α-ketoisocaproic acid (GAKIC) has previously been shown to improve exhaustive high-intensity exercise performance. There are no controlled studies involving GAKIC supplementation in well-trained subjects. The aim of the current study was to examine the effects of GAKIC supplementation on fatigue during high-intensity, repeated cycle sprints in trained cyclists. After at least 2 familiarization trials, 10 well-trained male cyclists completed 2 supramaximal sprint tests each involving 10 sprints of 10 s separated by 50-s rest intervals on an electrically braked cycle ergometer. Subjects ingested 11.2 g of GAKIC or placebo (Pl) during a period of 45 min before the 2 experimental trials, administered in a randomized and double-blind fashion. Peak power declined from the 1st sprint (M ± SD; Pl 1,332 ± 307 W, GAKIC 1,367 ± 342 W) to the 10th sprint (Pl 1,091 ± 229 W, GAKIC 1,061 ± 272 W) and did not differ between conditions (p = .88). Mean power declined from the 1st sprint (Pl 892 ± 151 W, GAKIC 892 ± 153 W) to the 10th sprint (Pl 766 ± 120 W, GAKIC 752 ± 138 W) and did not differ between conditions (p = .96). The fatigue index remained at ~38% throughout the series of sprints and did not differ between conditions (p = .99). Heart rate and ratings of perceived exertion increased from the 1st sprint to the 10th sprint and did not differ between conditions (p = .11 and p = .83, respectively). In contrast to previous studies in untrained individuals, these results suggest that GAKIC has no ergogenic effect on repeated bouts of high-intensity exercise in trained individuals.
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Hordiienko, O. I., and T. A. Hroshovyi. "Study of the quantitative factors influence on pharmaco-technological properties of powder masses and tablets with plant extracts and essential oil." Farmatsevtychnyi zhurnal, no. 1 (February 17, 2021): 35–42. http://dx.doi.org/10.32352/0367-3057.1.21.04.
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The available range of phytopreparations for topical use in the oral cavity does not fully meet the needs of patients as mainly medicinal plant raw materials and tinctures of domestic production represent it. Therefore, we developed a pharmaceutical composition in the form of tablets based on dry extracts herb of Geranium sanguineum L., Geranium sibiricum L. and essential oil of Salvia sclare. To optimize the composition of the tablets it is necessary to study and select the necessary excipients and their quantities, which was the purpose of the work.
 In order to study the influence of 10 quantitative factors on the properties of powder masses and the main quality indicators of tablets with plant extracts and essential oil, the method of random balance was used. The obtained powder mixtures and tablets based on them were subjected to the determination of the following pharmaco-technological parameters: bulk density, tapped density, flowability, the angle of repose, the uniformity of weight, tablet hardness testing, the friability test, disintegration time, desirability function.
 The pharmaco-technological index of bulk density improves with an increase in the amount of Pregelatinized Starch, Mannitol 60, Emcompress, as well as a decrease in the amount of Neusilin UFL2 and Neusilin US2. Regarding the tapped density, Neusilin US2 significantly affects it, with the increase of which this indicator decreases.
 With the introduction of more Neusilin US2, Mannitol 60, Pregelatinized Starch, Ludipress, Emcompress and Magnesium Stearate, the value of the angle of repose is improved.
 The average mass has the greatest influence on fluidity, at its decrease this indicator improves. The same happens with the introduction of Neusilin UFL2, Neusilin US2, Pregelatinized Starch and Magnesium Stearate.
 The uniformity of weight of all series of tablets fluctuates within ± 5%, and friability to 1%, which meets the requirements of the State Pharmacopoeia of Ukraine. Also, despite the results obtained, all series of tablets were very strong, with the lowest tablet hardness testing – 159 N. The disintegration of the tablets varies within 6 minutes.
 After evaluating the results of the scattering diagrams of all pharmaco-technological parameters as well as the desirability function, Neusilin US2, МCC 102, Sodium croscarmellose, Mannitol 60 and Magnesium Stearate were selected for further research. The average weight of tablets should be increased to 0.55 g.
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Sachuk, Roman, Yaroslav Stravskyy, Bogdan Gutyj, Tetiana Velesyk, Orest Katsaraba, and Sergii Zhyhaliuk. "Study of acute toxicity of the drug «Kolidev 8M» with a single intragastric injection in laboratory animals." ScienceRise: Biological Science, no. 2(27) (June 30, 2021): 44–48. http://dx.doi.org/10.15587/2519-8025.2021.235952.
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«Kolidev 8M» (powder for oral use) is a veterinary drug used to treat ornamental birds (pheasants, peacocks) in diseases of the digestive tract caused by microorganisms sensitive to colistin.
 In the study of the drug «Kolidev 8M» for oral administration, along with the confirmation of therapeutic properties, it is necessary to determine the LD50 obtained in the process of studying acute toxicity.
 The aim of research. The aim of research was to determine the acute toxicity of the veterinary drug «Kolidev 8M» (powder for oral administration) under the conditions of intragastric administration to white mice.
 Materials and methods of research. To achieve this aim, an experiment was conducted on 114 males of nonlinear white mice kept under optimal conditions in the vivarium of DEVIE LLC (Rivne, Ukraine). In the first series of experiments on the principle of analogues was formed control and three experimental groups of 6 animals each (n=6). The drug in the form of a solution was administered once orally using a esophageal gastric tube in doses of 500,0; 2000,0 and 4000,0 mg/kg body weight by absolute weight of the drug. The animals of the control group were injected with distilled water.
 After taking into account the results of the first experiment in the next experiment, 6 experimental groups were formed – mice, which were administered the drug «Kolidev 8M» in the form of a solution in doses (by absolute weight of the drug) – 500,0; 1000,0; 1500,0; 2000.0; 2500,0; 3000,0; 3500 and 4000,0 mg/kg body weight, as well as the control group – animals that were injected with distilled water with a volume of 0.5 cm3 according to similar regulations (Zapadniuk, 1983; Kotsiumbas, 2005; Karkyshchenko & Hrachev, 2010). There were 6 animals in each group (n=6). After their death, a pathological autopsy was performed (Zharov A. et al., 2003).
 The average lethal dose of LD50 was calculated by the method of probit analysis by Prozorovsky V.B.
 Research results. According to the results of research, it was found that the LD50 of the drug «Kolidev 8M» (powder for oral administration) under the conditions of its single intragastric administration to male mice is 2024,72±232,45 mg/kg, LD10 – 392,87 mg/kg, LD16 – 751,56 mg/kg, LD84 – 3297,88 mg/kg, LD90 – 3656,57 mg/kg, LD100 – 3934,47 mg/kg body weight, respectively.
 According to the results of an acute toxicological experiment with intragastric administration of the drug «Kolidev 8M» to white male mice, LD50 was 2024,72±232,45 mg/kg body weight. This allows, according to toxicity, to refer this drug to class IV – low-toxic substances (LD50 501,0-5000,0 mg/kg body weight), and the degree of danger to class III – moderately safe substances (LD50 151,0-5000,0 mg/kg body weight).
 Conclusions and prospects for further research. The drug «Kolidev 8M» in terms of toxicity belongs to class IV – low-toxic substances, and the degree of danger to class III – moderately safe substances.
 Further studies will be the next stage of pre-registration trials aimed at studying the subacute toxicity of the drug «Kolidev 8M»
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Modi, Vivek Suresh, Karan Jatwani, Sridevi Rajeeve, et al. "Comparison of Rivaroxaban with Argatroban in Heparin Induced Thrombocytopenia Using Historical Controls : A Case-Control Study." Blood 132, Supplement 1 (2018): 4996. http://dx.doi.org/10.1182/blood-2018-99-120364.
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Abstract Introduction Heparin-induced thrombocytopenia (HIT) is an uncommon and a serious complication of heparin therapy. Currently, only two intravenous Direct Thrombin Inhibitors (DTI) are approved for its therapy. However, their cost and frequent monitoring make the Direct-Acting Oral Anticoagulants (DOACs) an attractive option for its treatment. Several case series and systematic reviews have been published with positive results for use of NOACs in HIT. No head to head trials comparing NOACs and DTI have been published as infrequency of cases make such a study prohibitive. The landmark multicenter trials establishing the role of Argatroban in the treatment of HIT used historical controls to establish it's efficacy. In this study, we aim to compare a cohort of patients treated with Rivaroxaban as recruited from prior case series with a historical cohort treated with Argatroban to establish it's safety and efficacy compared to Argatroban. Methods: A literature review was done using Embase and Pubmed to find HIT patients treated with Rivaroxaban. A total of 14 publications were found including case studies, case series, and systematic reviews. A database was created of a total of 51 HIT patients treated with Rivaroxaban alone or argatroban followed by Rivaroxaban using all the publications. All the cases were confirmed HIT cases based on Serotonin release assay and/or HIT antibody. Platelet nadir and Platelet count at the start of therapy as noted wherever possible. Patients with known bleeding diathesis and bleeding sites were excluded from both the cohorts. Outcomes were thrombosis after initiation of therapy and bleeding after initiation of therapy. The cohort was compared with a historical cohort of patients treated with Argatroban alone in the paper published by Lewis et al. Chi-square test was done to compare new thrombosis and bleeding during hospitalization. Results: No significant difference was found in the rates of new thrombosis (OR: 0.18, CI: 0.02-1.36, p: 0.06). 5% of patients had major bleeding in the argatroban cohort while none of the patients had major bleeding in Rivaroxaban cohort. Conclusion: The study indicates that Argatroban is not significantly better in the treatment of HIT in preventing new thrombosis. However, the bleeding complications might be lower with Rivaroxaban therapy compared to Argatroban therapy. The study is limited by less than ideal comparability of cohorts and low power. However, it provides only such evidence of it's kind. Table. Table. Disclosures No relevant conflicts of interest to declare.
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Miyazaki, Yoshiyuki, Masaji Nakamizo, Kazuhiro Kawahara, Hideaki Takeuchi, Daisuke Tachikawa, and Koji Yamada. "Augmentation of salivary IgA production in healthy subjects by fucoidan-agaricus mix ingestion." Journal of Immunology 196, no. 1_Supplement (2016): 207.8. http://dx.doi.org/10.4049/jimmunol.196.supp.207.8.
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Abstract Fucoidan is a series of sulfated polysaccharides derived from brown algae, and have reported to have various biological activities. Previously, we demonstrated that fucoidan derived from Cladosiphon okamuranus and Undaria pinnatifida effectively augmented anti-tumor immunity in combination with Agaricus blazei mycelia extract. In this study, we evaluated the capacity of the fucoidan-agaricus mix (FAM) to enhance oral mucosal immune function. Fifteen healthy volunteers (mean age, 41.2 years old; range, 22–56 years old; 8 males, 7 females) ingested 4 capsules each containing 250 mg FAM powder every day for 12 weeks. As a result, the mean of secretory rates of salivary secretory immunoglobulin A (sIgA) tended to be increased by the FAM administration for 4 and 12 weeks as compared with the initial value. The enhanced salivary sIgA secretion was more distinctly observed in subject group whose initial values of salivary sIgA secretory rate were lower than the total average. Furthermore, the intake of FAM led to significant augmentation in the salivary sIgA secretion (by 1.3-fold) in the group of subjects under 40 years of age. On the other hand, concanavalin A-induced blastogenic response of peripheral blood mononuclear cells and serum IgA concentration was not elevated during this trial. Therefore, it was suggested that FAM stimulated functional maturation rather than expansion of B lymphocyte. The intake of FAM did not significantly affect NK cell activities. In addition, the safety of FAM consumption was confirmed because no abnormal findings were observed in general clinical tests. From the results, it was suggested that intake of FAM was useful in augmentation of oral mucosal immune defense via enhancing salivary sIgA production.
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Yamamoto, Katsumi, Hiroshi Noro, Yu Sato, et al. "Endoscopic submucosal dissection to relieve a flexure of the gastric conduit after esophagectomy." Endoscopy International Open 06, no. 03 (2018): E350—E353. http://dx.doi.org/10.1055/s-0043-121883.
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Abstract Background and study aims A 70-year-old-man underwent an esophagectomy and posterior mediastinal reconstruction for esophageal cancer that was curatively resected. Although the patient was allowed to eat after surgery, he repeatedly vomited after drinking water or eating meals and required continuous hospitalization. An upper gastrointestinal series and endoscopic examination revealed an obstruction due to the flexure of the gastric conduit, which was repeatedly treated with endoscopic balloon dilation. Endoscopic balloon dilation was completely ineffective, however, because the obstruction was not due to a small lumen diameter, but rather to severe flexure. We hypothesized that the power of contraction provided by ulcer scar formation after mucosal resection could straighten the flexure, and thus removed a piece of the mucosa 8 cm in diameter on the oral side of the flexure by endoscopic submucosal dissection (ESD) 4 months after the esophagectomy. Endoscopic examination on post-ESD Day 10 revealed that the gastric conduit flexure was straightened due to ulcer scarring, and obstruction at the flexure opened over time. Meals were restarted and the patient could eat without vomiting. He was discharged from the hospital 5 weeks after ESD. This is the first case report of obstruction due to flexure of the gastric conduit after esophagectomy that was successfully treated with mucosectomy using ESD. Mucosectomy using ESD may be an effective treatment option for obstruction due to flexure of the gastric conduit after esophagectomy.
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Ried, L. Douglas, Bentson H. McFarland, Richard E. Johnson та Kathleen K. Brody. "β-Blockers and Depression: The More the Murkier?" Annals of Pharmacotherapy 32, № 6 (1998): 699–708. http://dx.doi.org/10.1345/aph.17185.
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OBJECTIVE: To review the literature regarding the purported association between oral ingestion of β-blocker drugs and depressed mood. DATA SOURCE: MEDLINE was searched for published articles using the key words propranolol, atenolol, metoprolol, nadolol, timolol, β-blocker, β-adrenergic antagonist, or β-adrenergic blocker in combination with the key words depression, depressive symptomatology, major depressive disorder, or depressed mood from January 1966 through December 1996. DATA SYNTHESIS: Findings regarding the association are equivocal. Plausible explanations include study design, case definition, and confounding disease states. Most of the evidence supporting an association has used case series and case reports. Findings from cross-sectional observational studies and case–control studies are equivocal. Case definition and measurement instruments may partially explain these inconsistencies. Studies using a diagnosis of depression generally do not support the relationship. Trials using depressive symptoms are about evenly split, but they have generally enrolled a small number of patients and have questionable statistical power. Studies defining antidepressant prescriptions dispensed as a marker for depression generally support the association. Evidence exists both for and against the hypothesis that lipophilic β-blockers cause more depression than do hydrophilic β-blockers. CONCLUSIONS: β-Blockers may have been unjustly associated with depression and their use avoided for that reason. Future studies into the association between depression and β-blocker use should evaluate whether the association is affected by case definition and study design characteristics, including disease, dose–response, bias, measurement error, or ability to precisely measure the length of the exposure.
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Kayum, Shahin, Sahil Kooner, Ryan M. Khan, et al. "Safety and Effectiveness of Outpatient Total Ankle Arthroplasty." Foot & Ankle Orthopaedics 6, no. 4 (2021): 247301142110578. http://dx.doi.org/10.1177/24730114211057888.
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Background: Total ankle arthroplasty (TAA) is a surgical procedure commonly reserved for patients suffering from symptomatic end-stage ankle arthritis. As the number of TAAs increases, so does the associated economic burden. Given these economic constraints, there has been interest in the feasibility of outpatient TAA. The purpose of this study is to evaluate the safety, efficacy, and satisfaction of patients undergoing outpatient TAA. Methods: This is a retrospective case series of consecutive patients who underwent outpatient TAA from July 2018 to June 2019. Inclusion criteria included any patient undergoing a primary TAA in the outpatient setting. This was defined as discharge on the same day of surgery or within 12 hours of surgery. All surgeries were completed by a single experienced surgeon through an anterior approach using the Cadence Total Ankle System. Prior to surgery, all patients received a popliteal nerve block. Patients were then discharged home with oral analgesic and a popliteal nerve catheter, which they removed after 48 hours. The primary outcome of interest was postoperative pain control, which was measured using a numeric scale. Secondary outcomes included complication rate, readmission rate, and patient satisfaction. A review of the current literature was then completed to supplement our results. Results: In total, 41 patients were included in our analysis. In terms of the primary outcome, the average numeric scale score was 1.98, indicating excellent pain control. Additionally, nearly all 41 patients stated they were very satisfied with their postoperative pain control regimen. In terms of secondary outcomes, the majority of patients stated they were satisfied with discharge on the same day as surgery. There were no readmissions or major complications in our outpatient TAA cohort. When asked if they would recommend the care they experienced to a friend with the same condition, 95% of patients said that they would recommend this care pathway. Our literature review included 5 original studies, which were all retrospective level IV studies. These studies uniformly demonstrated the safety and efficacy of outpatient TAA. Conclusions: The results of our study demonstrate the outpatient TAA is associated with excellent pain control using a multidisciplinary pain approach. The use of standardized outpatient postoperative pathways was effective in preventing readmissions and complications, while still resulting in high patient satisfaction scores. A review of the literature complemented our results, as there are largely no significant differences between outpatient and inpatient TAA. Level of Evidence: Level IV, case series.
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Baer, A. S., Philip Houghton, Greg Bankoff, et al. "Book Reviews." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 156, no. 1 (2000): 107–68. http://dx.doi.org/10.1163/22134379-90003858.
Pełny tekst źródłaStreszczenie:
- A.S. Baer, Philip Houghton, People of the Great Ocean; Aspects of human biology of the early Pacific. Cambridge: Cambridge University Press, 1996, x + 292 pp. - Greg Bankoff, Vicente L. Rafael, Figures of criminality in Indonesia, the Philippines, and colonial Vietnam. Ithaca, NY: Cornell University Southeast Asis Program, 1999, 258 pp. - Harold Brookfield, Donald Denoon, The Cambridge history of the Pacific Islanders. Cambridge: Cambridge University Press, 1997, xvi + 518 pp., Stewart Firth, Jocelyn Linnekin (eds.) - Cynthia Chou, Shoma Munshi, Clifford Sather, The Bajau Laut; Adaptation, history, and fate in a maritime fishing society of south-eastern Sabah. Kuala Lumpur: Oxford University Press, 1997, xviii + 359 pp. - Cynthia Chou, Shoma Munshi, Krishna Sen, Gender and power in affluent Asia. London: Routledge, 1998, xiii + 323 pp., Maila Stivens (eds.) - Freek Colombijn, Arne Kalland, Environmental movements in Asia. Richmond, Surrey: Curzon, 1998, xiii + 296 pp. [Nordic Institute of Asian Studies, Man and Nature in Asia Series 4.], Gerard Persoon (eds.) - Kirsten W. Endres, Phan Huy Chu, Hai trinh chi luoc; Récit sommaire d’un voyage en mer (1833); Un émissaire Vietnamien à Batavia. Paris: EHESS, 1994, viii + 228 pp. [Cahier d’Archipel 25.] - Aone van Engelenhoven, Veronica Du Feu, Rapanui. London: Routledge, 1996, xv + 217 pp. [Routledge Descriptive Grammars.] - Fukui Hayao, Peter Boomgard, Paper landscapes; Explorations in the environmental history of Indonesia, 1997, vi + 424 pp. Leiden: KITLV Press. [Verhandelingen 178.], Freek Colombijn, David Henley (eds.) - Volker Heeschen, J. Miedema, Texts from the oral tradition in the south-western Bird’s Head Peninsula of Irian Jaya; Teminabuan and hinterland. Leiden: DSALCUL, Jakarta: ISIR, 1995, vi + 98 pp. [Irian Jaya Source Materials 14.] - Volker Heeschen, J. Miedema, Texts from the oral tradition in the southern Bird’s Head Peninsula of Irian Jaya; Inanwatan-Berau, Arandai-Bintuni, and hinterland. Leiden: DSALCUL, Jakarta: ISIR, 1997, vii + 120 pp. [Irian Jaya Source Materials 15.] - Robert W, Hefner, Daniel Chirot, Essential outsiders: Chinese and Jews in the modern transformation of Southeast Asia and Central Europe. Seattle: University of Washington Press, 1997, vii + 335 pp., Anthony Reid (eds.) - Bob Hering, Lambert Giebels, Soekarno, Nederlandsch onderdaan; Biografie 1901-1950. Amsterdam: Bert Bakker, 1999, 531 pp. - Karin van Lotringen, David Brown, The state and ethnic politics in Southeast Asia. London: Routledge, 1994, xxi + 354 pp. - Ethan Mark, Takashi Shiraishi, Approaching Suharto’s Indonesia from the margins. Ithaca, NY: Cornell University Southeast Asia Program, 1994, 153 pp. - Harry Poeze, J.A. Manusama, Eigenlijk moest ik niet veel hebben van de politiek; Herinneringen aan mijn leven in de Oost 1910-1953. Utrecht: Moluks Historisch Museum, ‘s-Gravenhage: Bintang, 1999, 301 pp. - Nico Schulte Nordholt, Hans Antlöv, Exemplary centre, administrative periphery; Rural leadership and the New Order in Java. Richmond, Surrey: Curzon Press, 1995, xi + 222 pp. [Nordic Institute of Asian Studies, Monograph Series 68.] - Cornelia M.I. van der Sluys, Danielle C. Geirnaert-Martin, The woven land of Laboya; Socio-cosmic ideas and values in West Sumba, eastern Indonesia. Leiden: Centre for Non Western Studies, Leiden University, 1992, xxxv + 449 pp. [CNWS Publications 11.] - Nicholas Tarling, Tom Marks, The British acquisition of Siamese Malaya (1896-1909). Bangkok: White Lotus Press, 1997, vii + 167 pp. - B.J. Terwiel, Chanatip Kesavadhana, Chulalangkorn, roi de Siam: Itineraire d’un voyage à Java en 1886. Paris: EHESS, 1993, vi + 204 pp. [Cahier d’Archipel 20.] - Jaap Timmer, Polly Wiessner, Historical vines; Enga networks of exchange, ritual, and warfare in Papua New Guinea, with translations and assistance by Nitze Pupu. Washington: Smithsonian Institution Press, 1998, xvii + 494 pp., Akii Tumu (eds.) - Robert van Niel, Margaret Leidelmeijer, Van suikermolen tot grootbedrijf; Technische vernieuwing in de Java-suikerindustrie in de negentiende eeuw. Amsterdam: Nederlandsch Economisch-Historisch Archief, 1997, 367 pp. [NEHA Series 3.] - Fred R. von der Mehden, Shanti Nair, Islam in Malaysian foreign policy. London: Routledge, 1997, xiv + 301 pp. - Lourens de Vries, Volker Heeschen, An ethnographic grammar of the Eipo language, spoken in the central mountains of Irian Jaya (West New Guinea), Indonesia. Berlin: Dietrich Reimer Verlag, 1998, 411 pp. - Waruno Mahdi, A. Teeuw, De ontwikkeling van een woordenschat; Het Indonesisch 1945-1995. Amsterdam: Koninklijke Nederlandse Akademie van Wetenschappen, 1998, 51 pp. [Mededelingen der Koninklijke Nederlandse Akademie van Wetenschappen (new series) 61-5.] - Roxana Waterson, Robert L. Winzeler, Indigenous architecture in Borneo; Traditional patterns and new developments, 1998, xi + 234 pp. Phillips, Maine: Borneo Research Council. [BRC Proceedings Series 5.]
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Vivcharyk, Nataliia. "Transformation of Folklore Images and Motifs in Dara Korniy’s Novel “Honykhmarnyk”." Journal of Vasyl Stefanyk Precarpathian National University 10, no. 1 (2023): 225–32. http://dx.doi.org/10.15330/jpnu.10.1.225-232.
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The article examines folklore motifs and images of Dara Kornyi's novel "Honykhmarnyk", which is offered to be analyzed in the Ukrainian literature class in the 11th grade in the context of studying modern literature. It is indicated that the writer contributed to the development of the urban fantasy genre, and her work is rooted in folklore and mythology, which will allow students to deepen their knowledge of oral folk art, to draw parallels with the works they studied in high school, in particular Lesia Ukrainka's "Forest Song" and "Shadows of forgotten ancestors" by Mykhailo Kotsiubynskyi. It is proven that the synthesis of arts as a characteristic feature of the style, folklore echoes, poetic epigraphs, and mentions of the names of famous artists significantly expand the context of the work and generate allusions that should be analyzed in class. The title of the novel and the names of individual sections indicate its connection with mythology and folklore. The work contains many legends, tales, and folk songs, and artistically interprets the image of a duplicitous man who belongs to the corpus of Ukrainian "lower mythology". The article analyzes the main signs of a two-headed person and also focuses on rituals that can reduce the power of Gradobur. In parallel with the image of Honykhmarnyk, the history of the herbalist family, to which Alina belongs, is described. A whole series of legends, tales, and superstitions are woven into the artistic fabric of the work, in particular, about the power of charms that protect against evil spirits. One of the aspects of the research was the legend of the family curse and Alina's efforts to break the closed circle. The struggle between good and evil in the work is marked as a confrontation between black and white magic.
 It has been proven that the Carpathian and Lviv topos play an important role in the novel, in the coordinates at which the main characters interact. It is revealed that nature reveals the true nature of the heroes, and the patron of the city guards the secrets of its inhabitants. It is illustrated that Dara Korniy resorts to erasing the boundaries between reality, memories, dreams, and real and parallel worlds, and paintings serve as a kind of portals to the afterlife. The main character tries to separate two beings and save the soul of her beloved. It is indicated that the journeys to the afterlife are filled with horror, so they resemble fragments of Gothic works, but the power of her love can overcome all obstacles.
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Viljoen, Jeanne-Marie. "Being (in)formed by indigenous voices: First steps to using graphic narratives to decolonise speculative fiction." Image & Text, no. 37 (November 1, 2023): 1–22. http://dx.doi.org/10.17159/2617-3255/2023/n37a37.
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The Greenlandic visual artist Nuka K. Godtfredsen and his literary and scientific collaborators have produced a series of four graphic narratives to represent distinct moments in Greenland's history, spanning the pre-colonised and colonial period. These narratives employ aspects of magic realism and adopt an approach to narrative that focuses on the supernatural and presents modes of being that contrast with their audiences' understanding of realities that are ordinarily (only) visible. I argue that these graphic narratives use strategies from speculative fiction that frame the modern European presence in Greenland and the narrative of colonialism as one of several multiple realities in the Arctic, rather than its central axis, leaving open the possibility for indigenous Greenlanders to speak on their own terms. This enables these graphic narratives to illuminate aspects of knowledge (including features of oral legend and supernatural encounters) that were previously discredited in colonial discourse. Furthermore, I show that attending to how embodied aspects of Greenlandic Inuit storytelling traditions can be captured in the graphic narrative medium may be an effective decolonial strategy, which could be employed by speculative fiction. I thus advocate methodologies for speculative fiction that strategically broaden its boundaries in order to address its intractable colonial legacy. Informed by approaches that focus attention on form - such as Marks's haptic visuality (2000) and visual theories of the power of hand-drawn comics (Groensteen 2010, Chute 2008) to engage the reader/viewer in both an embodied and reflective way - I assert that including graphic narratives which employ strategies of speculative fiction may present a unique opportunity for the genre to mount a powerful challenge to a colonial knowledge production.
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Radenkovic, Silvia, Christin Johnsen, Andreas Schulze, et al. "Novel insights into the phenotype and long-term D-gal treatment in PGM1-CDG: a case series." Therapeutic Advances in Rare Disease 4 (January 2023): 263300402211502. http://dx.doi.org/10.1177/26330040221150269.
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Phosphoglucomutase-1-congenital disorder of glycosylation (PGM1-CDG) (OMIM: 614921) is a rare autosomal recessive inherited metabolic disease caused by the deficiency of the PGM1 enzyme. Like other CDGs, PGM1-CDG has a multisystemic presentation. The most common clinical findings include liver involvement, rhabdomyolysis, hypoglycemia, and cardiac involvement. Phenotypic severity can vary, though cardiac presentation is usually part of the most severe phenotype, often resulting in early death. Unlike the majority of CDGs, PGM1-CDG has a treatment: oral D-galactose (D-gal) supplementation, which significantly improves many aspects of the disorder. Here, we describe five PGM1-CDG patients treated with D-gal and report both on novel clinical symptoms in PGM1-CDG as well as the effects of the D-gal treatment. D-gal resulted in notable clinical improvement in four patients, though the efficacy of treatment varied between the patients. Furthermore, there was a significant improvement or normalization in transferrin glycosylation, liver transaminases and coagulation factors in three patients, creatine kinase (CK) levels in two, while hypoglycemia resolved in two patients. One patient discontinued the treatment due to urinary frequency and lack of clinical improvement. Furthermore, one patient experienced recurrent episodes of rhabdomyolysis and tachycardia even on higher doses of therapy. D-gal also failed to improve the cardiac function, which was initially abnormal in three patients, and remains the biggest challenge in treating PGM1-CDG. Together, our findings expand the phenotype of PGM1-CDG and underline the importance of developing novel therapies that would specifically treat the cardiac phenotype in PGM1-CDG. Plain Language Summary An update on benefits and challenges of treating PGM1-CDG with galactose PGM1-CDG is a rare genetic disorder that affects glycosylation, an important biochemical process happening in every cell of the body. Because glycosylation is essential for correct functioning of the cells and happens in every tissue and organ, patients with PGM1-CDG can have a variety of symptoms affecting many different organs. Main symptoms include low blood glucose levels, hyperinsulinism, bleeding disorder, liver, muscle, heart problems, and so on. This disorder is usually diagnosed based on the genetic testing, patient’s symptoms, and transferrin glycosylation test, which detects abnormalities in glycosylation in blood. So far, more than 60 patients have been reported. Unlike many genetic disorders, PGM1-CDG has a treatment in the form of a sugar called galactose, which naturally occurs in milk, and can treat many symptoms of the disorder. The patients are advised to take it every day by mouth in the form of powder. Here, we describe five more patients with PGM1-CDG, who were treated with galactose. Each of the patients had novel symptoms and they responded to the treatment differently, which helps us to better understand the disorder and the effects of therapy better. We found that many symptoms improved or normalized; however, some patients experienced persistent symptoms and even adverse events that made them stop treatment. Unfortunately, we did not observe any improvement of heart-related issues. Given that heart issues are the most severe aspect of PGM1-CDG and can result in early death, therapies that target heart issues in PGM1-CDG are still necessary. In conclusion, we describe novel aspects of PGM1-CDG, which will help understand and diagnose the disorder better, and highlight the importance of developing new therapies for this disorder that would specifically treat the heart.
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Metz, Holly. "McFeely Muscle: The Campaign to Ruin George Harper." New Jersey Studies: An Interdisciplinary Journal 2, no. 1 (2016): 11. http://dx.doi.org/10.14713/njs.v2i1.24.
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<p>The twenty-two-year reign of Hoboken political boss Bernard N. McFeely (including seventeen as mayor) has long been under-reported in the national press and almost completely overlooked by historians. Bernard McFeely’s extensive FBI file, recently released under the Freedom of Information Act, provides an opportunity to remedy this lapse, and to consider his rule (1925-1947) alongside other post-World War I urban political machines. Unlike his over-boss, Jersey City mayor and statewide machine leader Frank Hague, or machine bosses in Boston, Memphis, and Kansas City—all of whom retained power by matching bullying with programs that gained the affection of poor and working class constituents—McFeely was stingy with public funds and mostly relied on force to secure his hold. The coercion and beatings attributed to McFeely and his cohorts in oral histories and court records are detailed in his FBI file. This article focuses on one series of documents, relating to a 1937-1938 campaign to ruin the milk business of George Harper, who was said to have displeased then-mayor McFeely by consorting with his political opponents. Harper provided the FBI with daily records of the enforced boycott of his business; they provide a blow-by-blow account of McFeely bossism in action.</p><p><span style="font-family: 'Times New Roman',serif; font-size: 10pt; mso-fareast-font-family: 'MS Mincho'; mso-fareast-theme-font: minor-fareast; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">A version of this talk was originally delivered at the NJ Forum Conference, Kean University, on November 22, 2014. </span></p>
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Fedosenko, A. А., Yu V. Scrypynets, I. I. Leonenko, A. V. Yegorova, S. N. Kashutskуy, and V. P. Antonovich. "Determination of the glucose residues on pharmaceutical equipment surfaces by both methods: polarimetry and HPLC." Farmatsevtychnyi zhurnal, no. 5 (September 4, 2018): 83–89. http://dx.doi.org/10.32352/0367-3057.5.15.05.
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Cleaning of equipment in the production of medicines is an important requirement of good manufacturing practice (GMP). As a rule, the same process equipment is used for the production of a number of different drugs that may result in cross-contamination. In order to prevent the contamination there is need in efficient cleaning of equipment used with the validation methods for each part of equipment. There is need as well to prove and establish acceptable residual limits of active pharmaceutical ingredients (API) on the surface of the equipment after purification (purity acceptance criteria) based on the therapeutic dose of API, toxicity, volume of series, the surface area of the used equipment.
 The aim of this work is the development of the simple and selective polarimetry and HPLC methods for determining residual amounts of glucose in washings from surfaces of pharmaceutical equipment after production of the drug. The object of the research is glucose, which is a part of the drug Regidron, powder for oral solution of 18.9 g per sachet. The swab Alpha® Sampling Swab TX715; membrane filters 0.20 µm; Minisart RC 15 «Sartorius» (Germany) were used. The polarimetric and HPLC methods for determination of glucose residues in washings from surfaces of pharmaceutical equipment after production the Regidron were developed.
 The recovery rates of glucose from swabs and pharmaceutical equipment surfaces are more than 90%. The proposed simple and rapid methods are characterized by satisfactory metrological characteristics and can be recommended to determine the residues of glucose in controlling the quality of cleaning pharmaceutical equipment.
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Fields, Neville J., Kirsten R. Palmer, Daniel L. Rolnik, et al. "CO-Sprout—A Pilot Double-Blinded Placebo-Controlled Randomised Trial of Broccoli Sprout Powder Supplementation for Pregnant Women with COVID-19 on the Duration of COVID-19-Associated Symptoms: Study Protocol." Nutrients 15, no. 18 (2023): 3980. http://dx.doi.org/10.3390/nu15183980.
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Since its discovery in late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been estimated to be responsible for at least 769.3 million infections and over 6.95 million deaths. Despite significant global vaccination efforts, there are limited therapies that are considered safe and effective for use in the management of COVID-19 during pregnancy despite the common knowledge that pregnant patients have a much higher risk of adverse outcomes. A bioactive compound found in broccoli sprout—sulforaphane—is a potent inducer of phase-II detoxification enzymes promoting a series of potentially beneficial effects notably as an antioxidant, anti-inflammatory, and anti-viral. A pilot, double-blinded, placebo-controlled randomised trial is to be conducted in Melbourne, Australia, across both public and private hospital sectors. We will assess a commercially available broccoli sprout extract in pregnant women between 20+0 and 36+0 weeks gestation with SARS-CoV-2 infection to investigate (i) the duration of COVID-19 associated symptoms, (ii) maternal and neonatal outcomes, and (iii) biomarkers of infection and inflammation. We plan to enrol 60 outpatient women with COVID-19 irrespective of vaccination status diagnosed by PCR swab or RAT (rapid antigen test) within five days and randomised to 14 days of oral broccoli sprout extract (42 mg of sulforaphane daily) or identical microcrystalline cellulose placebo. The primary outcome of this pilot trial will be to assess the feasibility of conducting a larger trial investigating the duration (days) of COVID-19-associated symptoms using a broccoli sprout supplement for COVID-19-affected pregnancies. Pregnant patients remain an at-risk group for severe disease following infection with SARS-CoV-2 and currently unclear consequences for the offspring. Therefore, this study will assess feasibility of using a broccoli sprout supplement, whilst providing important safety data for the use of sulforaphane in pregnancy.