Gotowe bibliografie tematyczne / Organ transplantation

Gotowa bibliografia na temat „Organ transplantation”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 1 sierpnia 2024

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Artykuły w czasopismach na temat "Organ transplantation"

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Tumin, Makmor, Khaled Tafran, Wan Ahmad Hafiz Wan Md Adnan i Ahmad Farid Osman. "Assessing Countries’ Deceased Organ Donation and Transplantation Performance". MARCH 2023 19, nr 2 (13.03.2023): 170–74. http://dx.doi.org/10.47836/mjmhs.19.2.25.

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Introduction: Donors per million population and transplantations per million population are standardized, widely used indicators to assess and compare countries’ performance in organ donation and transplantation. This study aims to investigate these two particular metrics of organ donation and transplantation performance, and to introduce a new index, namely, ‘transplantations per patients on the waiting list’. Methods: Secondary analyses of data on 23 countries in 2016 were used to construct the transplantations per patients on the waiting list indicator for kidney, liver, pancreas, heart, and lung transplantation, as well as for the transplantation of any of the five aforementioned organs. Results: According to the transplantations per patients on the waiting list, the best-performing countries in terms of organ donation and transplantation are Belarus for kidney transplantation, Finland for liver and pancreas transplantation, Australia for heart transplantation, and France for lung transplantation. Considering all five organs together, Sweden, Australia, Finland, Austria, and Poland were the top five best-performing countries, followed by Spain in the sixth position. Conclusion: The deceased transplantations per patients on the waiting list can be an alternative indicator to assess performance, along with the widely-used donors and transplantations per million population, but still has its limitations in certain scenarios.
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Vukovic, Milivoje, Nebojsa Moljevic, Zoran Milosevic, Nenad Katanic i Dragan Krivokuca. "Multiple organ procurement". Medical review 60, nr 7-8 (2007): 339–42. http://dx.doi.org/10.2298/mpns0708339v.

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Introduction. Liver transplantation is the most demanding of all solid organ transplantations. It requires perfect organization and motivation of health care professionals, patients and their families. This article deals with the procedure for multiple organ procurement, reviews criteria for organ donation and describes the surgical technique for multiple organ procurement. Discussion. Adequate selection and evaluation of cadaveric donors and of organs for transplantation should include early identification of potential donors, and early diagnosis of brain death. The procurement of the highest number of viable organs for transplantation requires excellence in each of the phases. Early and aggressive physiologic support in the maintenance of potential donors can reduce organ donor loss due to irreversible asystole or multiorgan failure (it is almost always possible to maintain organ perfusion pressure) and increase the number of organs without increasing post-transplant morbidity or mortality. The ideal donor is a young, previously healthy, brain dead, victim of an accident. Conclusion. The surgical procedure for multiple organ procurement from brain death donors must be performed without intraopertive organ damage. .
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Milijić, Svetlana, i Aleksandar Nikolić. "Ethics in Organ Transplantation". Acta Facultatis Medicae Naissensis 35, nr 2 (1.06.2018): 87–93. http://dx.doi.org/10.2478/afmnai-2018-0010.

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Abstract Organ transplantation is specific medical procedure which is used as a way of treatment. Transplantation is often the only way of curing a patient. Today, hundreds of people in the world live successfully with donor organs, and transplantations as medical interventions are performed routinely. In Europe, about 10,000 patients are saved annually by transplantation, but there are far larger numbers of those waiting for their so-called rescue organ. In all countries, transplant medicine is regulated by special laws, regulations and conventions that provide medical, legal, and ethical regulations. Organ donation is an act of charity and giving, and not a contract on movement. Righteousness and fairness are emphasized in transplantation medicine. The question of organ transplanting affects the most intimate issues of human integrity, human dignity, health and illness. That is why certain instructions, rules of conduct and treatment are required from ethics. Today, in ethical dilemmas regarding organ transplantation, less emphasis is placed on imperative ethics, which emphasizes the idea of obligation, and more emphasis is placed on the so-called indicative ethics in which the idea of general accountability and solidarity is in the foreground. In cases of transplanting organs from a living patient, it is a doctor`s duty to provide complete information to the donor and the recipient about the purpose and nature of the procedure itself, success probability, consequences, possible risks and noted adverse reactions. In cases of transplanting from a cadaver, the basic ethical question is defining brain death and respect for the deceased. The main reason of a small number of donors is lack of information, fear of organ donating and ethical questions related to transplantation.
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Opoku, John Kwaku. "ORGAN TRANSPLANTATION MEDICINE: RELIGIOUS AND ETHICAL CONSIDERATIONS". Volume-1: Issue-9 (November, 2019) 1, nr 9 (7.12.2019): 13–21. http://dx.doi.org/10.36099/ajahss.1.9.2.

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There are not enough solid organs available to meet the needs of patients with organ failure. Thousands of patients every year die on the waiting lists for transplantation. Yet there is currently available, underutilized, potential source of organs. Many patients die in intensive care following withdrawal of life-sustaining treatment whose organs could be used to save the lives of others. At present the majority of these organs go to waste. In this paper, I consider and evaluate a range of religious and ethical responses to improve the quality of organ transplantations available today. The responses of four world religions (Christianity, Islam, Buddhism and Hinduism) towards organ transplantation are considered. We argue that religious involvement in medical technologies like transplantation medicine gives to individuals the greatest chance of being able to help others with their organs after death under well-guided means. It is believed that attempts to increase patient autonomy will be realised in the light of religion and ethics.
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N.V. Kuznetsova, N. V. x., i A. I. Merzlyakova. "COMPARATIVE ANALYSIS OF THE LEGAL REGULATION OF ORGAN DONATION IN THE RUSSIAN FEDERATION, SWITZERLAND AND THE UNITED STATES OF AMERICA". Bulletin of Udmurt University. Series Economics and Law 32, nr 6 (24.11.2022): 1088–93. http://dx.doi.org/10.35634/2412-9593-2022-32-6-1088-1093.

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For a long time, the transplantation of organs and tissues from one person to another has remained an unsolvable medical problem. Nowadays, donor organ transplantation is a common and successful way to treat patients with terminal organ failure, which undoubtedly makes it more in demand. The largest percentage of all organ transplants involves transplants from people who have already died. In this regard, an important issue is the possibility for a person to express his or her will regarding the posthumous removal of organs for transplantation, and the mechanisms and possibilities of this expression of will as such. The article deals with the provisions of Russian, US and Swiss legislation regulating the organization and functioning of the organ transplantation system in each country; legal relations in the field of organ and tissue transplantation as well as the mechanisms of citizens' will regarding the posthumous removal of organs and tissues for transplantation purposes. Legal problems of realization of such will in the Russian Federation are covered. The ways of solving the arising problems are offered. The role of legislation, including the presumption on the removal of organs, and other factors influencing the increase in the number of transplantations carried out in the country are considered.
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Gautier, S. V., i S. M. Khomyakov. "Organ donation and transplantation in the Russian Federation in 2016 9th report of the National Registry". Russian Journal of Transplantology and Artificial Organs 19, nr 2 (23.06.2017): 6–26. http://dx.doi.org/10.15825/1995-1191-2017-2-6-26.

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Aim. To carry out monitoring of the organization and tendencies in the development of organ donation and transplantation in the Russian Federation in 2016. Materials and methods. Questioning of the heads of all the centers of transplantation is carried out. The comparative analysis of the obtained data in dynamics of the years, between certain regions of the Russian Federation and transplantation centers is done. Results. According to the register 35 centers of kidney transplantation, 22 centers of liver transplantation and 11 centers of heart transplantation were functioning in the Russian Federation in 2016. The waiting list of kidney transplantation in 2016 included 4818 potential recipients that make 14% of total number of the patients (35 000) receiving dialysis. The rate of donor activity in 2016 made 3.3 p. m. p. Efficiency of donor programs in 2016 continued to increase: the share of multiorgan retrieval made 64.1%, average number of organs received from one effective donor made 2.7. In 2016 the rate of kidney transplantation made 7.4 p. m. p., the rate of liver transplantation made 2.6 p. m. p.; the rate of heart transplantation made 1.5 p. m. p. In 2016 the number of transplantations in the Russian Federation increased by 14.8% in comparison with 2015 having overcome the level of 1700 organs transplantation. The Moscow region still remains to be the core of stability and development of the organ donation and transplantation in the country where 10 centers of transplantation function and half of all kidney transplantations and more than 70% of all liver and heart transplantations are carried out. Conclusion. The results of 2016 were positively affected by the introduction of targeted financial support of medical activity, related to organ donation, from federal budget resources. Among unresolved problems which constrain the development there are collision of legal regulation of licensing of medical activities for organ donation and transplantation, lack of the state order for the organization of transplantological medical care in each region, lack of responsibility of the heads of the regions and medical organizations for the organization of organ donation. Positive tendencies of the development of organ donation and transplantation in Russia call for further monitoring, strengthening and building.
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Kovtun, G. I., B. M. Todurov i O. A. Kanyura. "History and actual problems of organ donation". Cardiac surgery and interventional cardiology, nr 1-2 (19.09.2023): 5–14. http://dx.doi.org/10.31928/2305-3127-2023.1-2.514.

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The review is devoted to the history of the development of organ transplantation and the analysis of models of organ transplantation in countries that are leaders in the field of transplantation. Organs transplantation abroad has become an effective method of treatment that saves lives, but it is also an indicator of the success of the country’s development as a whole, an important element of national pride and prestige. However, performing transplantations is associated with problems of an organizational, as well as legal, moral and ethical nature. The main problem is a shortage of donor organs. The review analyzes measures aimed at increasing the level of donation in the world and promoting the development of transplantology.
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Glyantsev, S. P. "Phenomenon of Demikhov. In the Sklifosovsky Institute (1960–1986). Fighting "windmills" or lack of conditions (1961)". Transplantologiya. The Russian Journal of Transplantation 10, nr 4 (21.12.2018): 336–46. http://dx.doi.org/10.23873/2074-0506-2018-10-4-336-346.

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The article describes the results of V.P. Demikhov's working at N.V. Sklifosovsky Institute for Emergency Medicine in 1961. We have presented a brief report of his laboratory activities and a prospective working plan that included preparing for vital organ transplantations in clinic, conducting immunological and morphological studies, resolving resuscitation issues, all aimed at: 1) revitalizing dead people and their organs for transplantatio, and 2) preserving the vitality of the isolated organs before transplantation. For the first time in the history of national surgery, the question of "brain death" was raised as a criterion for the possibility of organ harvesting. However, the documents we have reviewed demonstrated that such a plan was impossible to be realized with the efforts of a single institution. V.P. Demikhov was advised to revise the plan, abridge it, and bring it into line with the modest potential of the Institute to organ transplantations.
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Tokalak, Ibrahim, Hamdi Karakayali, Gökhan Moray, Nevzat Bilgin i Mehmet Haberal. "Coordinating Organ Transplantation in Turkey: Effects of the National Coordination Center". Progress in Transplantation 15, nr 3 (wrzesień 2005): 283–85. http://dx.doi.org/10.1177/152692480501500313.

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In January 2001, the National Coordination Center, which brought tissue and organ procurement and transplantation under the Turkish Health Ministry, was established in Turkey. The main aims of this organization are to expand cadaveric donation and increase the number of transplantable organs supplied by cadaveric donors. We compared the proportions of cadaveric organ transplantations that were performed in Turkey before and after the national coordination system was established. Of all the cadaveric transplantations completed to date, 91.6% of kidney and 71.5% of liver procedures were done before implementation of the new system, and 8.4% and 28.5%, respectively, were performed after the system was established. The data show that the frequency of cadaveric donation has increased, as well as the number of cadaveric organ transplantations performed annually. The new national transplantation coordination system is making a good start at increasing cadaveric transplantation in Turkey. This system will hopefully lead to a larger organ pool and shorter waiting lists in future.
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Rodrigues-Filho, Edison Moraes, Cristiano Augusto Franke i José Roque Junges. "Lung transplantation and organ allocation in Brazil". Revista de Saúde Pública 53 (7.03.2019): 23. http://dx.doi.org/10.11606/s1518-8787.2019053000445.

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The philosophy of organ allocation is the result of two seemingly irreconcilable principles: utilitarianism and distributive justice. The process of organ donation and transplantation in Brazil reveals large inequalities between regions and units of the Federation, from the harvesting of organs to their implantation. In this context, lung transplantation is performed in only a few centers in the country and is still a treatment with limited long-term results. The allocation of the few organs harvested for the few procedures performed is defined mainly by chronology, a criterion that is not linked to necessity, which is a criterion of distributive justice, and neither to utility, a criterion of utilitarianism. This article reviews the organ allocation philosophy focusing on the case of lung transplantations in Brazil.
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Rozprawy doktorskie na temat "Organ transplantation"

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Desai, Rajeev Ramarao. "Organ transplantation related cancer". Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6907/.

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Cancer is an important cause of mortality among the recipients of organ transplantation. Cancer transmitted from the donors has poor outcome and the fear of such transmission results in non-acceptance of certain organs. Study of the recipients in the UK over 10 years identified 15 cases of transmitted cancers. The rate of cancer transmission was 0.05%.The risk of cancer transmission was 9 times higher from donors older than 45 years. A comparison of the organ donor data with the guidelines classifying the donor’s risk showed that a selected cohort of donors, who are classed as high risk of cancer transmission, could safely donate their organs resulting in valuable additional survival for the recipients, with low risk of cancer transmission. These results provide evidence, for modification of donor classification guidelines resulting in increased availability of safe organs for transplantation. The risk of recurrence after transplantation of cancers treated before transplantation was low in selected recipients undergoing transplantation after a 2 year-wait following the diagnosis of cancer. No association was found between the donor-recipient CMV status and the risk of post-transplant cancer. This research estimated the risk of cancer transmission to the organ transplant recipients enabling improved risk assessment in transplantation.
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Pummer-Verté, Lila. "Organ donation and transplantation /". Online version of thesis, 1995. http://hdl.handle.net/1850/12252.

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Ruers, Theodoor Jacques Marie. "Selective immunosuppression in organ transplantation". Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5415.

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Hardstaff, Ruth. "Compliance post solid organ transplantation". Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493240.

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The twentieth century was a time of a lot of advances in medicine, none more so than in the field of transplantation. Thanks to the pioneering work of many different people in a variety of different fields it is now possible to transplant bone marrow and solid organs. Transplantation is a truly multidisciplinary specialty where patient care is shared between physicians and surgeons. As in all medical specialties good nursing care is essential and requires a high degree of specialisation. Pathologists are key in post operative management in order to promptly diagnose problems so that treatment can be commenced with the minimum of delays.
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Shubane, Nancy. "Black critical care nurses' perceptions of organ donation and organ transplantation". Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-10262009-185326/.

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Puig-Pey, Comas Isabel. "Phenotypic and Transcriptional Biomarkers In Organ Transplantation". Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/927.

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This is a compound work comprising two independent studies.

1. Characterization of gamma-delta-T cell subsets in organ transplantation

gamma-delta-T cells are innate-type lymphocytes that preferentially act as regulators of local effector immune responses. Recent reports found an altered distribution of the two main subpopulations of blood gamma-delta-T cells (V-delta-1 and V-delta-2) in operationally tolerant liver transplant recipients. Based on this, gamma-delta-T cells subset quantification was proposed as a biomarker of immunologic risk in liver transplantation. The specific characteristics of gamma-delta-T cell subsets in transplantation remain however unknown. We have investigated here the phenotype, repertoire and functional properties of gamma-delta-T cell subsets in a large population of allograft recipients. Our results indicate that alterations in the gamma-delta-T cell compartment are not restricted to tolerant liver recipients. In fact, most immunosuppressed liver and kidney recipients also display an enlarged peripheral blood gamma-delta-T cell pool mainly resulting from an expansion of V-delta-1 T cells exhibiting an oligoclonal repertoire and different phenotypic and cytokine production traits than V-delta-2 T cells. We propose that persistent viral infections are likely to contribute to these alterations. Our data provide novel insight in the biology of gamma-delta-T cells and a rationale for exploring these lymphocytes in more depth into the pathogenesis of viral infections in transplantation.

2. Comparative Transcriptional and Phenotypic Peripheral Blood Analysis of Kidney Recipients under Cyclosporin A or Sirolimus Monotherapy
Due to its low level of nephrotoxicity and capacity to harness tolerogenic pathways, sirolimus (SRL) has been proposed as an alternative to calcineurin inhibitors in organ transplantation. However, the exact mechanisms underlying its unique immunosuppressive profile in humans are still not well understood. In the current study, we aimed to depict the in vivo effects of SRL in comparison with cyclosporine A (CSA) by employing gene expression profiling and multiparameter flow cytometry on blood cells collected from stable kidney recipients under monotherapy with either SRL or CSA. In addition, the overall effect of these drugs on immunoregulatory pathways was assessed by measuring a transcriptional signature characteristic of operationally tolerant kidney recipients. Samples from SRL recipients displayed an increased frequency of effector memory T cells and were enriched in NFkB-related pro-inflammatory expression pathways and in monocyte and NK cell lineage-specific transcripts. Furthermore neither SRL nor CSA induced a gene expression profile comparable with that of tolerant kidney recipients. In conclusion, we show here that the overall pattern of SRL effect in vivo is dominated by innate immune cells and NFkB-related pro-inflammatory events. These data provide novel insights on the complex effects of SLR on the immune system in clinical transplantation.
"Biomarcadors fenotípics i transcripcionals
en el transplantament d'òrgans"

TEXT:


1. Estudi de les cèl·lules T gamma-delta A l'al·lotransplantament d'òrgans

1.1 Objectius
- Investigació detallada de la freqüència, fenotip, repertori del TCR i característiques funcionals de les poblacions Vdelta1 i Vdelta2 en sang perifèrica en trasplantats.
- Determinar si l'òrgan trasplantat, la teràpia immunosupressora i la presència d'infeccions víriques influeixen en la distribució i propietats de les subpoblacions gamma-delta.
- Avaluar el valor clínic de la quantificació de les cèl·lules T gamma-delta com a biomarcador diagnòstic de trasplantats tolerants operacionals de fetge.

1.2 Resultats
Es van quantificar les poblacions de gamma-delta totals, Vdelta1, Vdelta2 i ràtio Vdelta1/Vdelta2 en 201 trasplantats de fetge estables (STA-Liver), 29 tolerants operacionals trasplantats de fetge (TOL), 50 trasplantats estables de ronyó (STA-Kidney), 50 malalts amb insuficiència hepàtica terminal (ESLD) i 34 controls sans (CONT). Vem observar un increment de la població gamma-delta total en tots els grups de pacients trasplantats respecte CONT, que venia determinat per un increment de la població Vdelta1, més significatiu en el cas dels TOL, i una disminució de Vdelta2.
Vem demostrar que les freqüències del fenotip són estables en el temps determinant el percentatge d'expressió de Vdelta1 i Vdelta2 dues vegades amb 14 mesos de diferència.
El fenotipatge realitzat a les poblacions Vdelta1 i Vdelta2 en 19 pacients STA-Liver, va mostrar que aquestes subpoblacions expressen marcadors cel·lulars de superfície, intracel·lulars i funcionals diferents entre si. Aquests marcadors, però no serviren per diferenciar una cohort de 9 TOL i 10 STA-Liver. Vàrem assajar la utilitat diagnòstica dels percentatges de Vdelta1 i Vdelta2 per diferenciar TOL i STA-Liver utilitzant una corba ROC. Els resultats no varen ser positius.
Vam correlacionar la freqüència d'infeccions víriques persistents amb la distribució de les subpoblacions T gamma-delta. CMV i HCV, provocaven una alteració independent entre si i significativa en el ràtio Vdelta1/Vdelta2. Vam estudiar, finalment la diversitat clonal del TCR de la població Vdelta1. Es va clonar i seqüenciar la CDR3 del TCR Vdelta1. Els TOL mostren una tendència, estadísticament significativa, cap a un repertori restringit del TCR Vdelta1. Vam determinar si aquestes seqüències de nucleòtids es traduïen en grups d'aminoàcids compartits en la CDR3 de V1 però el resultat fou negatiu.

1.3. Conclusions
- La majoria dels receptors d'un transplantament mostren un increment en sang perifèrica de la població de cèl·lules T gamma-delta.
- La distribució alterada en sang perifèrica de les subpoblacions T gamma-delta és estable en un període de temps establert.
- Les infeccions per CMV i HCV afecten la freqüència relativa de les subpoblacions gamma-delta i el ràtio Vdelta1/Vdelta2 en sang perifèrica en pacients trasplantats de fetge.
- Les cèl·lules T Vdelta1 mostren ser fenotípica i funcionalment diferents de les Vdelta2.
- El repertori de CDR3 del receptor de les cèl·lules T Vdelta1 està restringit en receptors de fetge tolerants operacionals.
- Ni la quantificació de subpoblacions T gamma-delta ni la seva caracterització fenotípica permeten discriminar de forma acurada entre TOL i els STA-Liver.

2. Anàlisi fenotípic i transcripcional de receptors d'un transplantament de ronyó en monoteràpia amb CsA o sirolimus

2.1 Objectius
- Establir els efectes in vivo de sirolimus i CsA en sang perifèrica utilitzant tècniques de cribatge d'alt rendiment, per generar un perfil fenotípic i transcripcional de les dues cohorts de pacients.
- Determinar l'expressió d'una sèrie de biomarcadors associats a tolerància en aquests pacients, a partir d'un perfil generat anteriorment en tolerants operacionals renals.

2.2 Resultats
Es varen determinar les diferències fenotípiques de les dues cohorts i vàrem determinar que els pacients tractats amb sirolimus (SRL) mostraven un increment en la població CD4 de memòria efectora (CD45RA-CCR7-) respecte els pacients CSA. El grup SRL també presentava un increment en l'expressió de cèl·lules Tregs (CD4+CD25highFoxp3+) comparat amb CSA.
Vam fer estudis de microarray d'Affymetrix a partir de sang perifèrica. Vam fer un anàlisi comparatiu de dades utilitzant SAM (FDR<5%). El resultat d'aquest anàlisi ens va permetre identificar un total de 486 gens upregulated i 586 gens downregulated en el grup SRL respecte CSA.
Per interpretar el conjunt de gens diferentment expressats vam utilitzar el mètode GSEA, que ens va permetre identificar un enriquiment en el grup SRL de vies de senyalització relacionades amb mTOR i vies pro-inflamatòries comparat tant amb CSA com amb el grup d'individus sans.
Utilitzant Haematolgy Expression Atlas vam identificar una representació significativa de trànscrits específics per monòcits i cèl·lules NK en SRL, i per cèl·lules T CD4+ i limfòcits B en el grup CSA.
El software IPA-Tox va identificar NFκB com la via de senyalització més representativa respecte els gens estudiats.
Per últim vàrem determinar la prevalença de biomarcadors relacionats amb tolerància operacional en pacients trasplantats de ronyót. Dels 37 pacients estudiats només 1 SRL i 3 CSA varen ser predits com a potencialment tolerants.

2.3 Conclusions
- Els receptors estables d'un transplantament de fetge en monoteràpia amb sirolimus presenten un increment significatiu de la població TregFoxp3+ respecte tractament amb CsA.
¬- El perfil d'expressió en sang perifèrica del pacients tractats amb sirolimus mostra un enriquiment en vies metabòliques pro-inflamatòries i gens involucrats ambla senyalització mTOR.
-IPA-Tox identifica, entre les respostes farmacològiques prèviament definides, a NFκB com la via de senyalització més toxicològica a partir dels gens diferentment expressats.
- L'aplicació d'una signature de tolerància operacional prèviament definida no és capaç d'identificar diferències entre els pacients tractats amb CsA i els que reben sirolimus.
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Ahmed, Irfan. "Improved techniques of organ preservation in transplantation". Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423000.

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Cohen, Bernard. "Balancing supply and demand in organ transplantation". [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=6980.

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Motallebzadeh, Reza. "Tertiary lymphoid organogenesis in solid organ transplantation". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608121.

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Falconer, Stuart John. "Tacrolimus pharmacogenomics in abdominal solid organ transplantation". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31355.

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Background: Abdominal solid organ transplantation has evolved from an experimental procedure to a well-established therapy within a few decades. This success is largely due to the introduction of calcineurin inhibitor immunosuppression. Tacrolimus is the most widely used calcineurin inhibitor but has a narrow therapeutic range which requires close drug monitoring to prevent both toxicity and inadequate immunosuppression. Previous studies in renal transplantation have shown that genetic polymorphisms, CYP3A5, CYP3A4*22 and ABCB1 can influence the bioavailability and pharmacokinetics of tacrolimus. These polymorphisms are closely linked to ethnicity and have never been studied in a Scottish population before. Additionally, increasing evidence suggests that high variability of tacrolimus is linked to increased graft loss in kidney transplant patients. Methods: 5889 subjects were genotyped for the genetic polymorphisms CYP3A5 A > G allele transition, CYP3A4*22 C > T and ABCB1 C > T transition. This included 4899 healthy individuals from Generation Scotland bio-resource and 990 patients who underwent renal, liver, or simultaneous pancreas kidney transplants or were organ donors. Tacrolimus dose, trough level and renal function were measured at 11 time points from date of transplant up to and including 12 months post-transplant. Clinical data including episodes of acute rejection, graft and patient survival were compared between the different genotypes. Separate analyses were undertaken for kidney, SPK transplants, as well as liver transplants, the latter looking at recipient and liver donor genotype. A separate cohort of 103 renal transplant patients converted from twice-daily to once-daily tacrolimus had their tacrolimus variability calculated and compared with graft survival. Results: The distribution of the 3 different genotypes of CYP3A5, CYP3A4*22 and ABCB1 were comparable with other Caucasian populations studied previously. In renal transplant recipient expression of the A allele (GA/AA) led to significantly increased dose requirements of tacrolimus and initially lower tacrolimus trough levels. The different genotypes of ABCB1 had no effect. Expression of a CYP3A4*22 T allele trended towards a lower tacrolimus dose requirement but this was not significant. There was no difference in renal function, graft survival or patient survival with any of the polymorphisms. SPK patients had comparable results. In the liver transplant patients, the donor genotype had a greater influence than the recipient one. The donors with CYP3A5 A allele expression had significantly higher tacrolimus dose requirements and lower initial tacrolimus levels. This was apparent to a lesser extent with the recipient expression of CYP3A5 and did not reach statistical significance at all time points. There was no significant difference in tacrolimus dose requirements or level with either donor or recipient expression of ABCB1 or CYP3A4*22. There was a significantly higher incidence of acute rejection in donor CYP3A5 A allele expressers of liver transplant patients in univariate and multivariate analysis. There was no significant different in acute rejection with ABCB1 or CYP3A4*22 genotype. No differences in graft or patient survival with either donor or recipient genotype of any of the 3 polymorphisms were noted. Conversion from twice-daily to once-daily tacrolimus in the first 12 months post-transplant reduced tacrolimus variability. Patients with high tacrolimus variability pre and post conversion had significantly greater graft loss than patients with low tacrolimus variability. Conclusion: CYP3A5 expression results in increased tacrolimus requirements to achieve adequate immunosuppression in renal transplant and SPK patients. Donor rather than recipient CYP3A5 expression is relevant for liver transplantation and dose requirements. There may be an association with donor CYP3A5 expression in liver transplant patients and acute rejection which needs further evaluation. ABCB1 and CYP3A4*22 do not appear to have a significant impact in any of the organ transplants. High tacrolimus variability is associated increased graft loss in renal transplant patients.
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Książki na temat "Organ transplantation"

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Klein, Andrew, Clive Lewis i Joren C. Madsen, red. Organ Transplantation. Cambridge: Cambridge University Press, 2011. http://dx.doi.org/10.1017/cbo9780511994876.

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F, Cardella John, i Amplatz Kurt, red. Organ transplantation. Philadelphia: Saunders, 1987.

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J, Roberts Arthur, i Painvin G. Arnaud, red. Organ transplantation. Philadelphia: Saunders, 1986.

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West, Richard. Organ transplantation. London: Office of Health Economics, 1991.

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M, Abouna George J., Kumar M. S. A i White Arthur G, red. Organ transplantation 1990. Dordrecht: Kluwer Academic Publishers, 1991.

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Mamode, Nizam, i Raja Kandaswamy, red. Abdominal Organ Transplantation. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118483664.

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Abouna, G. M., M. S. A. Kumar i A. G. White, red. Organ Transplantation 1990. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3386-9.

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H, Toledo-Pereyra Luis, red. Organ preservation for transplantation. Wyd. 3. Austin, Tex: Landes Bioscience, 2010.

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G, Gruessner Rainer W., i Benedetti E, red. Living donor organ transplantation. New York: McGraw-Hill, Health Professions Division, 2008.

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1926-, Starzl Thomas E., Shapiro Ron 1954- i Simmons Richard L. 1934-, red. Atlas of organ transplantation. New York: Gower Medical Pub., 1992.

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Części książek na temat "Organ transplantation"

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Ata, Barış, John J. Friedewald i A. Cem Randa. "Organ Transplantation*". W Handbook of Healthcare Analytics, 187–215. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781119300977.ch9.

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Iltis, Ana S. "Organ Transplantation". W Encyclopedia of Global Bioethics, 1–11. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-05544-2_317-1.

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Deutsch, Erwin, i Hans-Ludwig Schreiber. "Organ Transplantation". W Medical Responsibility in Western Europe, 674–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70449-9_71.

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Zaidi, Shabih H. "Organ Transplantation". W Ethics in Medicine, 197–210. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01044-1_7.

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Ellis, Harold, i Sala Abdalla. "Organ transplantation". W A History of Surgery, 237–47. Third edition. | Boca Raton, Florida: CRC Press, [2019] |: CRC Press, 2018. http://dx.doi.org/10.1201/9780429461743-15.

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Iltis, Ana S. "Organ Transplantation". W Encyclopedia of Global Bioethics, 2073–82. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-09483-0_317.

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Al-Bar, Mohammed Ali, i Hassan Chamsi-Pasha. "Organ Transplantation". W Contemporary Bioethics, 209–25. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18428-9_13.

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Stauch, Marc, i Kay Wheat. "Organ transplantation". W Text, Cases and Materials on Medical Law and Ethics, 537–90. Sixth edition. | Milton Park, Abingdon, Oxon ; New York, NY : Routledge, [2019]: Routledge, 2018. http://dx.doi.org/10.4324/9781315168326-11.

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Kirnap, Mahir, i Mehmet Haberal. "Organ Preservation". W Transplantation Surgery, 89–102. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55244-2_6.

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Spiegel, Hans U., i Daniel Palmes. "Organ Preservation". W Transplantation Surgery, 265–94. London: Springer London, 2001. http://dx.doi.org/10.1007/978-1-4471-3689-7_13.

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Streszczenia konferencji na temat "Organ transplantation"

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Pritsker, A. Alan B., Michael E. Kuhl, John P. Roberts, Margaret D. Allen, James F. Burdick, David L. Martin, Janet S. Reust i in. "Organ transplantation policy evaluation". W the 27th conference. New York, New York, USA: ACM Press, 1995. http://dx.doi.org/10.1145/224401.224813.

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Mladenović, Tamara. "Etički i pravni aspekti uzimanja organa od umrlih maloletnih lica". W XVI Majsko savetovanje. University of Kragujevac, Faculty of Law, 2020. http://dx.doi.org/10.46793/upk20.483m.

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Organ transplantation, as an extremely demanding, but impоrtant medical intervention, has always provided significant scope for opposing different legal and ethical principles. That scope is being expanded by considering the possibility that a sensitive category of persons, such as minors, may appear in the role of donor. While transplantation of organs from living minors is prohibited for the above reasons, cadaveric transplantation of organs from deceased children is legal in the law of the Republic of Serbia. This paper analyzes precisely such legally regulated organ donation, which implies the possibility of the appearance of a deceased minor as a donor. While, on the one hand, there is a growing need to take organs from children in order to transplant them and preserve the life of another child of appropriate age, such a decision has a significant emotional impact, above all, on the parents of the child. Keeping in mind that parents appear as the only authorized holders of the right to decide on the transplantation of an organ of a deceased minor, it is necessary to analyze the legal nature of the rights they have on the body and organs of the child. Also, it is necessary to point out the importance of more precise legal regulation of the conditions under which such transplantation can be performed, as well as the necessity of ensuring the autonomy of the will of the minor in terms of organ donation, which he could achieve for life.
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Mladenović, Tamara. "Etički i pravni aspekti uzimanja organa od umrlih maloletnih lica". W XVI Majsko savetovanje. University of Kragujevac, Faculty of Law, 2020. http://dx.doi.org/10.46793/upk20.483m.

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Organ transplantation, as an extremely demanding, but impоrtant medical intervention, has always provided significant scope for opposing different legal and ethical principles. That scope is being expanded by considering the possibility that a sensitive category of persons, such as minors, may appear in the role of donor. While transplantation of organs from living minors is prohibited for the above reasons, cadaveric transplantation of organs from deceased children is legal in the law of the Republic of Serbia. This paper analyzes precisely such legally regulated organ donation, which implies the possibility of the appearance of a deceased minor as a donor. While, on the one hand, there is a growing need to take organs from children in order to transplant them and preserve the life of another child of appropriate age, such a decision has a significant emotional impact, above all, on the parents of the child. Keeping in mind that parents appear as the only authorized holders of the right to decide on the transplantation of an organ of a deceased minor, it is necessary to analyze the legal nature of the rights they have on the body and organs of the child. Also, it is necessary to point out the importance of more precise legal regulation of the conditions under which such transplantation can be performed, as well as the necessity of ensuring the autonomy of the will of the minor in terms of organ donation, which he could achieve for life.
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Wang, Jinguo, i Na Wang. "Organ Transplantation and Relevant Law". W 2016 International Conference on Education, Management Science and Economics. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/icemse-16.2016.72.

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Živojinović, Dragica. "NAČELA POSTUPKA PRESAĐIVANjA LjUDSKIH ORGANA U SRPSKOM PRAVU". W XVIII Majsko savetovanje. University of Kragujevac, Faculty of Law, 2022. http://dx.doi.org/10.46793/xviiimajsko.587z.

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Organ transplantation is a form of a specialty treatment aimed at saving, prolonging and improving the quality of life of gravely ill patients. Although the organ transplantation is a field of medicine, this procedure is connected to the need for respecting and protecting of a number of individual rights which makes it also the subject of the regulatory framework. In that context, the goal of this paper is to investigate the principles which lay the grounds for the procedure of human organs transplantation in Serbian law and to answer the question whether the provisions of Serbian Law on human organ transplantation allow the adequate implementation of these principles. In order to reach this goal, the author of this paper compares the national concepts on this matter to those adopted in German and Croatian law, as well as to those foreseen in the European supranational law passed by the Council of Europe. Following a detailed analysis of the meaning and the scope of influence of each of four major Serbian law principles of human organ transplantation on the protection of basic human rights and dignity of both the organ donor and recipient, which constitutes the major part of the paper, in the concluding remarks the author presents her recommendations for the improvement of the existing norms regulating this matter.
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Rao, Vinaya, Ravi S. Behara i Ankur Agarwal. "Predictive Modeling for Organ Transplantation Outcomes". W 2014 IEEE International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2014. http://dx.doi.org/10.1109/bibe.2014.58.

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Nazarov, V. V., i A. K. Martusevich. "MICROWAVE MONITORINGOF ORGAN VIABILITY DURING TRANSPLANTATION". W Terahertz and Microwave Radiation: Generation, Detection and Applications (ТЕRА-2023). Moscow: Our Style, 2023. http://dx.doi.org/10.59043/9785604953914_74.

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Naveed, Khushbakht, Zofishan Hameed, Aqsa Khalid, Adeena Hamid, Beenish Fatima i Amna Batool. "Exploratory study on organ donation and organ transplantation in Pakistan". W ICTD '19: Tenth International Conference on Information and Communication Technologies and Development. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3287098.3287145.

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Srilatha, P., K. Siri Reddy, A. Sruthi Reddy, Devarasetty Kedhar i Moru Bhavana. "Organ Connect: A Digital Platform for Organ Donation and Transplantation". W 2023 3rd International Conference on Innovative Mechanisms for Industry Applications (ICIMIA). IEEE, 2023. http://dx.doi.org/10.1109/icimia60377.2023.10426416.

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V, Siva Sankar, i Sukanya S. T. "Using Hashing Algorithm for the Organ Procurement and Transplant Network". W The International Conference on scientific innovations in Science, Technology, and Management. International Journal of Advanced Trends in Engineering and Management, 2023. http://dx.doi.org/10.59544/slmx2075/ngcesi23p55.

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Today’s organ donation and transplantation systems pose different requirements and challenges in terms of registration, donor-recipient matching, organ removal, organ delivery, and transplantation with legal, clinical, ethical, and technical constraints. Therefore, an end-to-end organ donation and transplantation system is required to guarantee a fair and efficient process to enhance patient experience and trust. Propose a private Ethereum blockchain-based solution to enable organ donation and transplantation management in a manner that is fully decentralized, secure, traceable, auditable, private, and trustworthy. Develop smart contracts and present six algorithms along with their implementation, testing, and validation details. Evaluate the performance of the proposed solution by performing privacy, security, and confidentiality analyses as well as comparing our solution with the existing solutions. As a result, a ranked list is generated as an output and provided to the transplantation surgeons. Next, the transplant surgeon decides whether the organ is appropriate for the patient based on various considerations, such as the donor’s medical records and the current health of the prospective recipient. Later, when a transplant surgeon accepts the donated organ, the donor’s surgeon is notified to remove the donated organ.
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Raporty organizacyjne na temat "Organ transplantation"

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Basu, Sayani. Organ Transplantation: A New Lease of Life. Science Repository, luty 2021. http://dx.doi.org/10.31487/sr.blog.24.

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There is a growing debate over organ transplantation which is a successive therapeutic option for the treatment of end-stage organ diseases but the ethical issues associated with the shortage of transplantable organs must also be taken into account.
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Fallon, John, Richard Dumbill i Peter Friend. Organ preservation in renal transplantation. BJUI Knowledge, wrzesień 2023. http://dx.doi.org/10.18591/bjuik.0753.

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Callison, Kevin, Michael Darden i Keith Teltser. Externalities from Medical Innovation: Evidence from Organ Transplantation. Cambridge, MA: National Bureau of Economic Research, wrzesień 2023. http://dx.doi.org/10.3386/w31673.

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De Mel, Stephanie, Kaivan Munshi, Soenje Reiche i Hamid Sabourian. Herding with Heterogeneous Ability: An Application to Organ Transplantation. Cambridge, MA: National Bureau of Economic Research, październik 2021. http://dx.doi.org/10.3386/w29412.

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Wang, Li Fang, Yan Ting Cao, Tegeleqi Bu, Lin Fu, Jun Li Liu i Jing Zhao. Do We Receive Cytomegalovirus Vaccination Before Solid Organ Transplant: a Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, listopad 2022. http://dx.doi.org/10.37766/inplasy2022.11.0143.

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Review question / Objective: We compared cytomegalovirus (CMV) vaccination for solid organ transplantation recipients ( SOTs) with placebo treatment, to investigate the efficacy and safety for the prevention of CMV infection in SOTs. Condition being studied: Patients after solid organ transplantation subsequently become immunosuppressed, and cytomegalovirus (CMV) is the most common opportunistic pathogen to this population. The prevalence of CMV infection can reach 50% in the general population, and further up to 64-72% in solid organ transplant recipients (SOTs). CMV seropositive donors (CMV D+) puts even more pressure of CMV infection for SOTs. Post-transplant CMV infection can lead to neutropenia, lymphopenia, thrombocytopenia, tissue/end-organ invasive CMV disease (gastroenteritis, pneumonia, hepatitis, encephalitis), other infectious diseases, graft dysfunction, and multiple organ failure. CMV can disturb immune cell function, thus is one of the major risk factors that increase mortality within 6 months after transplantation. However, practical, effective method to prevent postoperative CMV infection for SOTs remains unresolved. Vaccination of CMV is only at clinical trials stage. To date, there is a lack of guidelines or consensus for preventing CMV disease for SOTs. Given the increasing clinical trials of CMV vaccination, it is important to clarify the evidence-based benefits and risks of CMV vaccination for SOTs, and to provide the best CMV disease prevention measurements.
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Bornholz, Robert, i James Heckman. Measuring Disparate Impacts and Extending Disparate Impact Doctrine to Organ Transplantation. Cambridge, MA: National Bureau of Economic Research, grudzień 2004. http://dx.doi.org/10.3386/w10946.

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Kaufman, Christina L. Positioning Vascularized Composite Allotransplantation within the Spectrum of Solid Organ Transplantation. Fort Belvoir, VA: Defense Technical Information Center, październik 2014. http://dx.doi.org/10.21236/ada618393.

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zhang, mingxiong, xiang ma, xuejun wang, guiting zhang, mengqiu zheng, weihao ma i youguo dai. Effect of Remote Ischemic Conditioning on organ transplantation: a meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, maj 2023. http://dx.doi.org/10.37766/inplasy2023.5.0056.

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Goodmonson, Courtney. Donation of organs for transplantation : an investigation of attitudes and behavior. Portland State University Library, styczeń 2000. http://dx.doi.org/10.15760/etd.454.

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Jin, Dachuan, Zhongfeng Cui, Tao Zhou, Baoqiang Guo, Shunqin Jin, Guangming Li i Chunming Zhang. Comparison of therapeutic effects of various stem cell types, sources, and routes of administration on chronic decompensated cirrhosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, styczeń 2023. http://dx.doi.org/10.37766/inplasy2023.1.0050.

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Review question / Objective: The aim of this study was to compare the therapeutic effects of various stem cell types, sources and routes of administration on chronic decompensated cirrhosis by using network meta-analysis. Condition being studied: Liver cirrhosis is an important public health problem that puzzles the world. It is divided into compensatory stage and decompensated stage. Once the patient enters decompensated stage, the treatment is very limited, and liver transplantation is currently the best and only approach to improve the survival rate of decompensated cirrhosis4. However, liver transplantation is difficult to be widely applied due to the lack of donor organs and high cost. Therefore, it is very important to study the alternative treatment of liver transplantation. Stem cell therapy as a promising frontier treatment for decompensated cirrhosis, is becoming one of the best feasible alternatives to liver transplantation in recent 20 years. It is very important and necessary to optimize the factors such as cell sources, types, and delivery route, etc. before taking stem cell therapy as a routine clinical treatment. It is believed that the network meta-analysis of the efficacy of various types of stem cells from different sources and routes of administration in the treatment of chronic decompensated cirrhosis can provide useful very clues for clinical practice.
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