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Gotowa bibliografia na temat „Or 4-1561”

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Data publikacji: 25 lipca 2024

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Artykuły w czasopismach na temat "Or 4-1561"

Mahiques Climent, Joan, i Helena Rovira Cerdà. "'Aquí se contienen cuatro obras muy santas', todas expurgadas y atribuidas a Joan Timoneda". SCRIPTA. Revista Internacional de Literatura i Cultura Medieval i Moderna 2, nr 2 (16.12.2013): 108. http://dx.doi.org/10.7203/scripta.2.2651.

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Resumen: Estudiamos y editamos las siguientes poesías devotas: 1) Digas, hortelano; 2) A vos, Virgen pía, estrella que guía; 3) Yo conozco, digo y cuento; 4) Oíd, reina que al cielo. La edición más antigua conocida que las reúne todas, aunque sine notis, se publicó en Valencia hacia 1561-1563, con una rúbrica que atribuía la primera a Joan Timoneda, la tercera a Francisco de Argüello y la última a Ángel González. Otros testimonios posteriores, y también algunos índices expurgatorios, consideran que las cuatro obras fueron compuestas por Timoneda, a quien Pere Salvà i Mallén asignó de manera más particular la segunda, es decir la Pavana de Nuestra Señora, aunque esta fue impresa en un pliego poético datable hacia 1533-1535 y, por tanto, parece anterior al período de actividad literaria del mencionado poeta. Si durante los siglos XVI-XVII estos poemas se difundieron conjuntamente en forma de pliego suelto, se nota la ausencia de testimonios impresos en el Setecientos, justo cuando entraron en los índices de libros prohibidos. Aparte de describir las fuentes antiguas localizadas, establecemos algunas conexiones entre estas cuatro obras y otras muestras poéticas circunscritas al contexto valenciano de mediados del siglo XVI.Palabras clave: Siglo XVI, poesía castellana, transmisión textual, edición, Valencia, Joan Timoneda, contrafactumAbstract: We study and edit four Spanish poems with the following opening lines: 1) Digas, hortelano; 2) A vos, Virgen pía, estrella que guía; 3) Yo conozco, digo y cuento; 4) Oíd, reina que al cielo. The earliest known edition that includes all of them was published sine notis (but probably in Valencia from 1561 to 1563) with a rubric that attributed the first work to Joan Timoneda, the third one to Francisco de Argüello and the last one to Ángel González. Some later literary sources and indexes of forbidden books consider that the four pieces were composed by Joan Timoneda, at whom Pere Salvà i Mallén assigned more specifically the second poem, titled Pavana de Nuestra Señora, although it was printed in a chapbook datable circa 1533-1535 and therefore it seems written prior to Timoneda’s output. These four pieces were published together in chapbook form during the sixteenth and seventeenth centuries, but there is no evidence of its printed transmission during the eighteenth century, just when they were expurgated. We describe some known printed books and manuscripts transmitting these poems, and we relate them to another poetic works emerged in mid-sixteenth century Valencia.Keywords: Sixteenth century; Spanish poetry; textual transmission; edition; Valencia; Joan Timoneda; contrafactum

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Xue, Fei, Jinjiang Li i Min Zhang. "Distribution of α p 2 Modulo One with Prime Variable p of a Special Form". Journal of Mathematics 2021 (6.03.2021): 1–22. http://dx.doi.org/10.1155/2021/5516049.

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Let P r denote an almost-prime with at most r prime factors, counted according to multiplicity. In this paper, it is proved that, for α ∈ ℝ / ℚ , β ∈ ℝ , and 0 < θ < 10 / 1561 , there exist infinitely many primes p , such that α p 2 + β < p − θ and p + 2 = P 4 , which constitutes an improvement upon the previous result.

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Orlovskiy, B. M., i I. A. Osadcha. "THE TOPICAL ISSUES OF LEGISLATIVE REGULATION OF CRIMINAL OFFENSES AGAINST SEXUAL FREEDOM AND PERSONAL INVIOLABILITY". Constitutional State, nr 43 (26.10.2021): 143–50. http://dx.doi.org/10.18524/2411-2054.2021.43.240992.

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The article is devoted to the study of topical issues of legislative regulation of criminal offenses against sexual freedom and sexual integrity of the person, provided for Articles 152–1561 of the Criminal Code of Ukraine. In the process of research the author identified a number of shortcomings and gaps in their legislative regulation, namely: 1) contradictions in terms of «the child» (the Criminal Code does not specify which age group is included in this concept), «the minor» (a person aged 14 to 18 under Article 32 of the Civil Code of Ukraine) and «the person under 16 years of age». These contradictions arise between the content of the dispositions and the titles of Articles 156 «Corruption of minors» and 1561 «Solicitation of children for sexual purposes» of the Criminal Code of Ukraine; 2) it lack of legislative concretization of the concept of «indecent assault» in Art. 156 «Corruption of minors»; 3) dualism and competition of legal norms in the application of Part 4 of Art. 152 «Rape» and Art. 155 «Committing acts of a sexual nature with a person under the age of sixteen», associated with the presence in both articles of the possibility of «voluntary consent» of «the person under 14 years of age» to commit sexual intercourse; 4) clarification of the possibility of practical application of Art. 1561 «Sexual harassment of a child». The author proposed the following changes and additions to the provisions of the Criminal Code of Ukraine to eliminate these shortcomings: 1) to formulate the name of Art. 156 as «Corruption of a person under the age of sixteen» and Art. 1561 as «Solicitation for sexual purposes of a person under the age of sixteen»; 2) to define the concept of «lecherous acts» in Art. 156 «Corruption of minors», for example, as «acts related to the physical and/or intellectual depravity of the victim in the sexual sphere», including those related to «exposure or touching the genitals, incitement to natural and unnatural sexual intercourse, conducting cynical conversations on sexual topics»; 3) to exclude from the text of the disposition part 4 of Art. 152 the concept of «voluntary consent» and supplement Art. 155 by the part 3, that provides the next: «The acts provided in part one of this article, committed against a person under the age of fourteen, – will be punishable by imprisonment for a term of ten to fifteen years». It is the presence of legible, consistent and justified criminal law norms in criminal offenses against sexual freedom and integrity of the person will ensure reliable legal protection of moral values of the child and society in Ukraine and proper implementation of criminal law policy of the Ukrainian state.

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Api, A. M., D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli i in. "RIFM fragrance ingredient safety assessment, hexanoic acid, 4-methyl-, CAS Registry Number 1561-11-1". Food and Chemical Toxicology 122 (grudzień 2018): S780—S788. http://dx.doi.org/10.1016/j.fct.2018.11.050.

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Tarkiainen, Kari. "Tallinna ja Harju-Viru rüütelkonna alistumine Rootsile 1561: vormid ja põhjused [Abstract: The capitulation of the town of Tallinn and the Harju-Viru knighthood to Sweden in 1561: forms and causes]". Ajalooline Ajakiri. The Estonian Historical Journal, nr 1 (3.05.2017): 39. http://dx.doi.org/10.12697/aa.2017.1.02.

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The subjugation of Northern Estonia to Swedish rule in 1561 is described in all general presentations of history, yet by and large, the course of events has not been traced in newer research. This period of history is very remarkable in three aspects. First of all, it was important for Sweden’s political history because over the course of the subsequent hundred years, Sweden became a major power in the Baltic Sea region, in reference to which the expression dominium maris Baltici is used. Secondly, the events of 1561–62 were of local importance because they led to the demise of the State of the Livonian Order in Livonia, which also meant the end of the Middle Ages in that region. The third viewpoint concerning the effect of these events to constitutional law is perhaps even more important. They started the transformation of previously unitary Sweden into a European conglomerate state where in addition to the motherland, there were other distinctive parts with different rights, so called provinces. Only a part of this chain of events will be examined in this study, namely the visit of the Swedish envoys Klas Kristersson Horn, Hans Larsson Björnram and Herman Bruser to Tallinn from March to June of 1561 and the events following this visit after the coronation of the king in Stockholm towards the end of the summer. There is abundant source material related to the deliberations (correspondence, presentations, documents verifying privileges, descriptions of oral conversations) and part of it has been published, but there are many loose ends in this material, first and foremost in regard to questions related to constitutional issues. A completely new picture of the history of the birth of Sweden as a great power emerges as a result of the careful reading of the sources. Unlike later developments, to a great extent the initiative came from Tallinners themselves. Their vision was affected both by the fear of Russia and by the wish to use the opportunities offered by trade with the east. Complete concord prevailed in these matters between the Tallinners and Sweden’s young king Erik XIV. The Harju-Viru knighthood and the nobility of Järvamaa followed the example of Tallinn’s senior magistrates and town council. The vote with acclamation that took place in Tallinn, where the participants chose “with hand and mouth” the king of Sweden as their ruler, was of central importance. This was followed by detailed consultations, where Horn, Björnram and Bruser in accordance with their authorisation agreed to the existing privileges of the corporations. Two separate “acts of recognition” (Huldigung) took place in Tallinn on 4 and 6 June 1951, the content of which was typical in the case of the declaration of the sovereign as ruler. The central elements of these ceremonies were the oath of allegiance and the affirmation of the ruler, ecclesiastical ceremonies and various kinds of expressions of joy. After this, a delegation from the knighthood and the city travelled to Sweden, but they were late (perhaps for diplomatic reasons) for the king’s coronation celebrations held in Uppsala in June of 1561. In this way they did not have to take the oath of allegiance the same way as the Swedes. The final phase of the events took place in audiences with Erik XIV in Stockholm as well as its surrounding area. The promises and the written oaths taken in Tallinn were reviewed on the basis of Sweden’s legal expertise and even though the Swedes were not always satisfied with them, the king affirmed them all the same. He was emphatically benevolent and even approved the privileges presented by the delegations without reading them, asking only whether there was not anything in them contrary to natural law. Thus the privileges of both the knighthood and the city were approved in Norrköping on 2 August 1561. The Riksradet (Council of the Realm) did not participate in making the final decisions and the king also did not request any recommendation from the Riksdag (Sweden’s parliament). Instead, he relied on the permit that Riksdag had already granted to Gustav Vasa in the summer of 1560 “to set foot in Livonia”. The reason as seen from Sweden for incorporating Tallinn and its surrounding region was undoubtedly primarily mercantile. Several features of the policy of Erik XIV, and the selection of envoys (Horn and Björnram) from among persons who knew Russian trade the best, are indicative of this. Yet other reasons also had their effect, for instance state security and the ruler’s ambition and vanity. On the whole, Sweden’s path to becoming a great power can be explained on the basis of the complexity theory and especially the path dependence featured in this theory, where decision-making is limited to the path that has previously been selected. The distinctive feature of the events that took place in Tallinn was the fact that they had the strong support of the city’s inhabitants and that very little military force was used, while on the other hand money was spent liberally to pay for both bribes and awards.

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Latupapua, Andrias Izaac. "Groundwater Investigation with Geoelectrical Method in Dulah Laut Village, Tual City". Agrologia 11, nr 1 (14.05.2022): 12. http://dx.doi.org/10.30598/ajibt.v11i1.1538.

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Groundwater availability in small islands with limestone is generally low. In order determine the availability and quality of groundwater, geoelectrical measurements were carried out with the Schlumberger electrode configuration on two tracks of Dulah Laut 1 and Dulah Laut 2. The results showed that the rock resistivity in Dulah Laut Village ranged from 27.4 – 1561 Ωm. Groundwater at the Dulah Laut 1 and Dulah Laut 2 were found at a depth of 5.21 m and 7.93 m below ground surface, respectively. The groundwater potential zone with resistivity of less than 150 Ωm was found at a depth of 4 m below the surface. Groundwater quality was classified as moderately polluted with high salinity.

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Омар, Мохаммед, Фарук Омар, Мухамаджон Идибоевич Исмоилов i Андрей Владимирович Остроух. "Using of Pattern Recognition in Various Specialization". Automation and Control in Technical Systems, nr 4 (19.01.2015): 32. http://dx.doi.org/10.12731/2306-1561-2014-4-4.

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Ekkart, Rudolf E. O. "Twee onbekende luiken met stichtersportretten door Aertgen van Leyden". Oud Holland - Quarterly for Dutch Art History 114, nr 2-4 (2001): 125–30. http://dx.doi.org/10.1163/187501701x00424.

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AbstractIn the Musée des Beaux-Arts at Lille there are two shutters from a North-Netherlandish commemorative painting (fig. 2/3) which on comparison with two others in the museums at Valenciennes (fig. i) and La Fère may be attributed to the painter Aertgen van Leyden. The coats of arms painted on the outsides of the shutters (fig-4/5) identify the sitters as Claes Alewijn Claeszz., burgomaster of Leiden (d. 1561), and his wife Anna Cornelisdr. van der Hooch (d.1558) with their children. The whereabouts of the central panel are unknown, but the work must have been painted for the Pieterskerk in Leiden, where the same couple's tombstone, made by the Frisian carver Pieter Dircksz., still is (fig. 6).

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Karpina, Veronika R., Svitlana S. Kovalenko, Sergiy M. Kovalenko, Oleksandr G. Drushlyak, Natalya D. Bunyatyan, Victoriya A. Georgiyants, Vladimir V. Ivanov, Thierry Langer i Louis Maes. "A Novel Series of [1,2,4]Triazolo[4,3-a]Pyridine Sulfonamides as Potential Antimalarial Agents: In Silico Studies, Synthesis and In Vitro Evaluation". Molecules 25, nr 19 (30.09.2020): 4485. http://dx.doi.org/10.3390/molecules25194485.

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For the development of new and potent antimalarial drugs, we designed the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment. The library of 1561 compounds has been investigated by both virtual screening and molecular docking methods using falcipain-2 as a target enzyme. 25 chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC50 = 2.24 and 4.98 μM, respectively. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs.

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Wipfli, Mark S., Richard W. Merritt i William W. Taylor. "Low Toxicity of the Black Fly LarvicideBacillus thuringiensisvar.israelensisto Early Stages of Brook Trout (Salvelinus fontinalis), Brown Trout (Salmo trutta), and Steelhead Trout (Oncorhynchus my kiss) following Direct and Indirect Exposure". Canadian Journal of Fisheries and Aquatic Sciences 51, nr 6 (1.06.1994): 1451–58. http://dx.doi.org/10.1139/f94-145.

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Mortality of brook trout (Salvelinus fontinalis), brown trout (Salmo trutta), and steelhead trout (Oncorhynchus mykiss) from eyed embryo to 82 mm fork length, exposed to Bacillus thuringiensis var. israelensis (B.t.i.) in the laboratory increased when dosages exceeded recommended rates by 12 000× or more. There was generally no toxicity difference between denatured (autoclaved) and nondenatured B.t.i. for all three trout species at all B.t.i. concentrations tested, indicating that mortality was due to formulation components and not B.t.i. toxin. The 48-h LC50values for brown and brook trout alevins ranged from 1561 to 2321 ppm for both denatured and nondenatured B.t.i. Scanning electron micrographs showed particle and mucus accumulation on gill surfaces from fish exposed to 2000 ppm B.t.i. for 4 h. Oxygen and carbon dioxide levels in blood from exposed (4000 ppm B.t.i. for 4 h) and unexposed fish were similar. Brown trout of 43 mm fork length fed excess B.t.i.-killed or live black flies (Cnephia dacotensis) ate similar quantities of each larval type, and both groups experienced similar mortalities and growth rates at 30-d postexposure.

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Rozprawy doktorskie na temat "Or 4-1561"

Boni, Enrica. "Temporalités dans les Novelle de Matteo Bandello et les Ecatommiti de Giovan Battista Giraldi Cinzio". Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCA168.

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Cette étude se propose d’enquêter sur les temporalités dans les Novelle (1554 et 1573) de Matteo Bandello et dans les Ecatommiti (1565) de Giovan Battista Giraldi Cinzio. Ces deux ouvrages se distinguent des autres recueils de nouvelles du XVIe siècle par leur proximité chronologique et, surtout, par leurs singularités et nouveautés structurelles : émiettement temporel et formel de l’histoire-cadre dans le recueil de Bandello ; et irruption, au milieu des successions narratives du novelliere de Giraldi, d’un long texte théorique, Dialoghi della vita civile, dont les trois parties correspondent aux trois âges de la vie (l’enfance, l’adolescence et l’état adulte). Nos auteurs, qui ont vécu les secousses des Guerres d’Italie, puis la stabilité retrouvée sur des bases nouvelles, rendent compte, par des choix très différents dans l’approche du modèle du Décaméron, d’une période de transformation sociale, politique, culturelle et scientifique qui questionne plusieurs aspects de la nature et de la maîtrise du Temps. Après une première partie consacrée à l’analyse du temps chronologique et des données concrètes et mesurables (indication de l'heure, représentation des âges de la vie humaine), l'étude examine la mise en fiction des temporalités dans les deux recueils, afin de saisir les possibles enjeux théoriques de la construction narrative de la durée. L'analyse se focalisera en particulier sur les rapports entre « temps du récit » et « temps de l'histoire », ainsi que sur les liens entre dimensions temporelle et spatiale.Enfin, l'étude abordera la question de la mise en écriture du présent historique des auteurs, à partir des conceptions linguistiques et historiographiques de chacun. De ce point de vue, les perspectives différentes (mais parfois convergentes) de Bandello et de Giraldi infléchissent la mise en écriture de l’Histoire dans leurs recueils respectifs, en déterminant une élaboration complexe du rapport entre passés proche et lointain, présent et futur
This study aims to investigate temporalities in Matteo Bandello’s Novelle (1554 and 1573) and Giovan Battista Giraldi Cinzio’s Ecatommiti (1565). These two literary works are distinct from other sixteenth-century collections of novellas in their chronological proximity and, above all, their structural innovations and peculiarities: temporal and formal fragmentation of the frame story in Bandello’s collection; and the irruption, amid the narrative sequences of Giraldi’s novelliere, of a long theoretical text, Dialoghi della vita civile, made up of three parts that correspond to the three stages of life (childhood, adolescence and adulthood). The authors, who experienced the upheavals of the Italian Wars, then stability restored on a new foundation, approach the model of the Decameron in very different ways, while each giving an account of a time of social, political, cultural and scientific change that questions many aspects of nature and man’s mastery over Time. After a first part, which concentrates on the treatment of chronological time and concrete, measurable data (indications of time, representations of the stages of human life), the study considers the fictional presentation of time lines in the two collections, in order to grasp the possible theoretical issues of the narrative construction of time scales. The analysis will especially focus on the relationships between “narrative time” and “discourse time”, as well as on the links between temporal and spatial dimensions. Finally, the study addresses the issue of putting the historical present of the authors in writing, relying on the linguistic and historiographical views held by each of them. From this point of view, the different (though sometimes convergent) perspectives of Bandello and Giraldi influenced the way in which History was put in writing in their respective collections, triggering an intricate relationship between near and distant past, present and future

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Vanballenberghe, Nathalie. "Aspects of genre in the secular vocal music of Cornelis Verdonck (1563/4-1625)". Thesis, University of Aberdeen, 2007. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231717.

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The composer Comelis Verdonck (1563/4-1625) lived and worked in Antwerp at end of the sixteenth century and early seventeenth century. Although his compositions were published in famous anthologies, his life and work remained neglected. Max Seiffert and Paul Bergmans both worked on Verdonck's biography. However, the popularity of the name Verdonck and the lack of official documents made their task a difficult one. Although it had been suggested that there might have been two musicians with the same name, until now, no one has disentangled the evidence. First hand research in the Antwerp City Archive and Antwerp Cathedral Archive has brought new material to light proving that there were at least two musicians called Comelis Verdonck associated with Antwerp at the end of the sixteenth century. One of them is responsible for the music forming the subject of this study. In the course of this thesis, Comelis Verdonck will be placed within the context of musical life in Antwerp, his relations with his patrons and colleagues, and the importance of his works within the Antwerp print culture. Two case studies will highlight the aspects of genre and Verdonck's predilection for the French texted compositions. A comparative study ofVerdonck's chanson Thyrcis vouloit mourir with Italian madrigals setting Guarini's poem Tirsi morir volea and an examination of Bicinia Sive Cantiones (1590) (an anthology of two-voice works including several ofVerdonck's works) reveal the great influence of madrigal writing on the chanson genre. Verdonck's two major publications Poesies Françoises (1599) and Madrigali a Sei (1603) will each be examined in separate chapters. This study is completed by the first modem edition of all known (some incomplete) works by Verdonck.

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Floren, Michael. "Capturing Complex Microenvironments for Directed Stem Cell Differentiation". Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1569/1/Floren_Thesis_(4).pdf.

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Loss of vascular function associated with cardiovascular disease, such as arthrosclerosis, represents the leading medical epidemic in the United States and typically requires surgical intervention through synthetic or autologous vascular grafts. To overcome the limitations associated with adult cell sources, which are often restricted by supply or compromised by disease, mesenchymal stem cells (MSCs) have emerged as potential candidates for vascular tissue engineering. While evidence suggests the roles of several factors influencing MSC differentiation into vascular phenotypes, including matrix rigidity, geometry and chemistry, the phenomena associated with these events are still largely unknown. Further, the development of mature vascular phenotypes, such as vascular smooth muscle cells (vSMCs), with functional behavior remains elusive to the research community. This thesis proposed to engineer and direct specific and mature vascular differentiation from MSCs by way of highly tailored matrices mimicking the vascular niche environment. Taking inspiration from natural organization, we contend that a biomimetic design approach to tissue scaffolds that display features of the natural cellular microenvironment whilst mimicking the bulk tissue properties may elicit highly specific differentiation of MSCs to vascular phenotypes. To validate our hypothesis, we employed a systemic approach incorporating physical and chemical microenvironmental cues, i.e. stiffness, biological ligands and chemical factors, with the aim to augment vascular phenotype expression, functionality, and final incorporation into a tailored biomaterial scaffolds. First, we present a novel technique for the preparation of silk hydrogels directly from high pressure CO2 environments without the need for crosslinking agents or additional additives such as surfactants or co-solvents. Through this novel method, we demonstrate the utility of CO2 as a volatile electrolyte, capable of sufficiently influencing the sol-gel transition of silk proteins, resulting in the formation of stable hydrogels with properties suitable for biomedical applications. Second, we hypothesized that suitable soluble factor regimen and matrix rigidity can instruct MSC differentiation towards more mature, functional vSMCs. To address this, we investigated cellular differentiation on tunable SF hydrogels prepared using a solvent-free CO2 processing method. The focus of this portion of the thesis is on exploiting the combined use of substrate stiffness and growth factor (TGF- β1) on SF matrices, with the aim of correlating the effects on the vascular commitment of human mesenchymal stem cells (hMSCs). Our data reveal that hMSC differentiation into mature SMCs can be achieved within modest culture periods (72 h) by combining appropriate SF hydrogel stiffness (33 kPa) with growth factor (TGF-β1). These findings advance our understanding of how complex multicomponent biomaterials, whereby mimicking the intricacy of natural tissue environments, can play a significant role in developing optimal stem cell differentiation protocols. Third, we postulated that the presentation of ECM proteins on 3D matrices with tunable stiffness will augment the differentiation of MSCs to vascular lineages. To address this, we established a high-throughput ECM platform based on soft, fibrous PEG hydrogels meanwhile highly-tunable in stiffness and 3-dimensional geometry. Using this technique, we identified several microenvironments supporting MSC adhesion, spreading and differentiation toward early vascular lineages. This portion of the thesis supports the hypothesis that a complex milieu exists coupling protein functional behavior with substrate rigidity and that this phenomenon may potentially be exploited through proper application of high-throughput screening methodologies. In the final work of this thesis, we explored the integration of ECM-derived small engineered peptides with 3D soft matrices to refine the differentiation of MSCs to vascular phenotypes, and further successfully recapitulate the complex vascular niche necessary for specific and efficient MSC differentiation into vascular lineages. In line with this, we report the development of a microarray platform based on electrospun nanofibrous hydrogels of photoclickable thiol-ene poly(ethylene glycol) (PEG) hydrogels. Here, we demonstrate the ability to control primary cell adhesion to soft, fibrous hydrogels functionalized with RGD peptide. However, future work will be focused on designing combinatorial peptide studies, whereby, the integration of several biological ligands of interest with tunable physical properties can instruct stem cell differentiation in a highly specific manner. This thesis has provided fundamental insights into the effects of physiological stimuli on vascular differentiation of MSC in terms of the specificity and maturity of the final differentiated cells. Better understanding of such mechanisms will prove paramount in the sequential stages of MSC differentiation to mature vascular cells. Additionally, the findings of this thesis will help to better define the process of regenerating functional healthy vascular tissue from MSCs. Altogether, a combinatorial approach investigating the effects of matrix elasticity, biological ligands and growth factors on MSC differentiation in a 3D nanofiber culture will be critical towards understanding and recapitulating MSC differentiation in the in vivo vascular environment.

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Lücken, Jana. "Transformations of Energy-Related Small Molecules at Dinuclear Complexes". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-1563-4.

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Feuchtinger, Clas-Steffen [Verfasser]. "Vernunft auf Anordnung : Das Kindeswohl im Elternstreit bei Trennung und Scheidung Pflichtberatung gemäß § 156 Abs. 1 S. 4 FamFG als Ausdruck von Elternverantwortung und Staatlichem Wächteramt gemäß Art. 6 Abs. 2 GG / Clas-Steffen Feuchtinger". Frankfurt : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2012. http://d-nb.info/1042426511/34.

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Maldonado-Arocho, Francisco J. "Characterization of host-pathogen interaction of two bacterial toxins anthrax edema toxin and Escherichia coli cytolethal distending toxin /". Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1973060671&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Lipsky, Ari Moshe. "Bayesian decision-theoretic trial design operating characteristics and ethics, an approximate method, and time-trend bias /". Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1970030561&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Davis, Ann. "So I'm done because I'm confused now measuring metacognition in elementary algebra community college students /". Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=2026651711&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Potter, Philip Barton Key. "Soft interdependence and international conflict". Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1970606971&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Cho, Hye-Won Jennifer. "Performance practice issues in Franz Schubert's Fantasy in C major ("Wanderer fantasy"), D. 7960". Diss., Restricted to subscribing institutions, 2010. http://proquest.umi.com/pqdweb?did=2023755691&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Książki na temat "Or 4-1561"

Ballabriga, Mariano Alejandro Faci. Crónica del Justicia de Aragón D.Juan de Lanuza V, 1563/4-2000. [Zaragoza]: El Justicia de Aragón, 2000.

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Orlovskie derevni: Rekonstrukt︠s︡ii︠a︡ istoricheskogo sostava, 1566-2014 gg. : v 4-kh tt. Orël: Izdatelʹstvo FGBOU VO Orlovskiĭ GAU, 2015.

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Glaser, Josef. Schönbrunner Chronik: Versuch einer bau- und wohngeschichtliche Dokumentation über 4 Jahrhunderte, 1560-1987. Wyd. 4. Wien: Schlosshauptmannschaft Schönbrunn, 1987.

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Mistelis, Loukas A. Comparative International Commercial Arbitration. The Hague, Netherlands: Kluwer Law International, 2003.

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Naranjo, Claudio. Charakter und Neurose. Wiesbaden: Springer Fachmedien Wiesbaden, 2017. http://dx.doi.org/10.1007/978-3-658-15611-4.

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Sassen, Barbara. Gezondheidsbevordering door verpleegkundigen. Houten: Bohn Stafleu van Loghum, 2016. http://dx.doi.org/10.1007/978-90-368-1560-4.

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Friesen, Jeff. Java I/O, NIO and NIO.2. Berkeley, CA: Apress, 2015. http://dx.doi.org/10.1007/978-1-4842-1565-4.

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Herman, Gabor T., i Attila Kuba, red. Discrete Tomography. Boston, MA: Birkhäuser Boston, 1999. http://dx.doi.org/10.1007/978-1-4612-1568-4.

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Rocha, Álvaro, José Luís Reis, Marc K. Peter i Zorica Bogdanović, red. Marketing and Smart Technologies. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1564-4.

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Moore, Paul A. The Hidden Power of Smell. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-15651-4.

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Części książek na temat "Or 4-1561"

Hanlon, Gregory. "French wars of religion 1561–1629". W European Military Rivalry, 1500–1750, 63–77. Abingdon, Oxon : Routledge, 2020.: Routledge, 2020. http://dx.doi.org/10.4324/9780429428913-4.

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Alesius, Alexander. "4. Assertio (1564)". W Antitrinitarische Streitigkeiten, 132–75. Göttingen: Vandenhoeck & Ruprecht, 2013. http://dx.doi.org/10.13109/9783666560156.132.

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Bajetta, Carlo M. "Letter 4 February–April/May 1566". W Elizabeth I's Italian Letters, 25–44. New York: Palgrave Macmillan US, 2017. http://dx.doi.org/10.1057/978-1-137-43553-8_4.

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Martin, J. C. "Hull Lecture No. 4 Fast Circuits, Diodes and Cathodes for e-Beams". W J. C. Martin on Pulsed Power, 117–23. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1561-0_8.

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Hirota, E., K. Kuchitsu, T. Steimle, J. Vogt i N. Vogt. "156 C8H8O3 4-Hydroxy-3-methoxybenzaldehyde". W Molecules Containing Three or Four Carbon Atoms and Molecules Containing Five or More Carbon Atoms, 333. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41504-3_287.

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"4 Luis de Góngora y Argote (1561–1627): Into the Dark". W Love Poetry in the Spanish Golden Age, 95–133. Boydell and Brewer, 2013. http://dx.doi.org/10.1515/9781782041832-006.

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"III. France: Paris And Poitiers (1563/4–1569)". W Andrew Melville and Humanism in Renaissance Scotland 1545-1622, 61–99. BRILL, 2011. http://dx.doi.org/10.1163/ej.9789004205390.i-375.20.

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Zon, Bennett. "A General Introduction to Post-Tridentine Liturgical Books and Plainchant in Europe". W The English Plainchant Revival, 7–8. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780198165958.003.0003.

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Abstract The Council of Trent was convened officially by Pope Paul III (1534-49) in a bull of 22 May 1542. On I 3 December 1545 the Council assembled for the first time, attended by a rather small group including ‘three legates, one cardinal, four archbishops, twenty-one bishops, and five generals of orders’. Over the next eighteen years the Council convened for twenty-five sessions until its last meeting on 4 December 1563. Decrees concerning music occurred late in the proceedings, namely at sessions 22, 23, and 24, on 17 September 1562, 15 July 1563, and II November 1563 respectively. Amongst the many concerns addressed at these sessions were ‘the curtailment of liturgical texts, the unintelligibility of the sacred words, the insertion of non-churchly songs, and worldly and lengthy organ compositions’ . Of these issues it was the curtailment of liturgical texts, particularly in regard to the hymns of the Breviary, which would directly affect the development of plainchant.

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Miola, Robert S. "Nicholas Sander". W Early Modern Catholicism, 58–62. Oxford University PressOxford, 2007. http://dx.doi.org/10.1093/oso/9780199259854.003.0006.

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Abstract In the Wrst wave of Catholic exiles under Elizabeth, Nicholas Sander (1530–81) became a priest and professor of theology at Louvain. He wrote a weighty defence of the Church, De visibili monarchia ecclesiae (Louvain, 1571), as well as a Catholic account of the changes in religion in England, De schismate Anglicano (Cologne, 1585) (see histories). His A Treatise of the Images of Christ (1566) defended Catholic beliefs and practices against Protestant iconoclasm, speciWcally against the attack of Bishop Jewel, A Reply unto M. Harding’s Answer (1565), who condemned Catholic veneration of images as idolatry (see also Foxe’s depiction, Fig. 4). In the selections below Sander recalls with horror the Lutheran desecration of Catholic icons in Antwerp.

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"1562 4 Elizabeth". W The Elizabethan New Year’s Gift Exchanges, 1559–1603, redaktor Jane A. Lawson, 55–72. British Academy, 2013. http://dx.doi.org/10.1093/oseo/instance.00098722.

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Streszczenia konferencji na temat "Or 4-1561"

Sun, Jing, Linjun Chen, Xiaohui Deng i Siguo Hao. "Abstract 1561: Leukemia cell-derived exosomes targeted dendritic cells can induce more strong anti-leukemia response than exosomes alone". W Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1561.

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Greenwood, Alexander C. B., Andi Shahaj, Changjia Chen, Brian T. Kirby, Alexei V. Gladyshev, Peter G. Kazansky i Li Qian. "Towards the Generation of Photon Pairs at 780 and 1560 nm in Periodically-Poled Silica Fiber". W CLEO: Applications and Technology. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/cleo_at.2023.jtu2a.93.

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We show the Sum-Frequency Generation characteristics of our periodically-poled silica fiber source for spontaneous parametric downconversion at 780 and 1560 nm; efficiencies are on an order of 4 × 10-6 and photon bandwidths of ~489 GHz.

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Jung, Doohwan, Jong Seok Park, Gregory V. Junek, Sandra I. Grijalva, Sagar R. Kumashi, Adam Wang, Sensen Li, Hee Cheol Cho i Hua Wang. "A 21952-Pixel Multi-Modal CMOS Cellular Sensor Array with 1568-Pixel Parallel Recording and 4-Point Impedance Sensing". W 2019 Symposium on VLSI Circuits. IEEE, 2019. http://dx.doi.org/10.23919/vlsic.2019.8778043.

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Misra, Anil, i Lance A. Roberts. "Probabilistic Axial Load Displacement Relationships for Drilled Shafts". W Geo-Frontiers Congress 2005. Reston, VA: American Society of Civil Engineers, 2005. http://dx.doi.org/10.1061/40777(156)4.

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Laporta, P., i O. Svelto. "Diode Pumped Erbium-Ytterbium Microlasers". W The European Conference on Lasers and Electro-Optics. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/cleo_europe.1996.ctul4.

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Laser oscillators based on Er3+-doped glasses and fibers have recently become the subject of great interest, in particular for their potential use in optical communication systems operating in the 1530-1560 nm region [1-2]. In the last few years, miniaturized, practical and efficient ErbiumYtterbium glass lasers, end-pumped at 980 nm by InGaAs semiconductor lasers, have been developed by our group [3-4]. These devices are based on a suitably codoped Erbium and Ytterbium phosphate glass, where the concentrations of both dopant ions have been optimized to enhance the absorption of the pump light in very short absorption lengths (200 μm to 2.5 mm) and to achieve low threshold pump powers and high slope efficiencies. The basic resonator structure is very short (a few mm) and compact. CW single-frequency operation may be achieved either by inserting an intracavity Fabry Perot etalon as the mode selecting element [4], or using a monolithic microchip cavity with a mode separation larger than the gain bandwidth of the laser medium [5].

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Simões, Gianna Monteiro Farias, i Solange Maria Leder. "No desconforto do lar". W XIX ENCONTRO NACIONAL DE TECNOLOGIA DO AMBIENTE CONSTRUÍDO. UFRGS, 2022. http://dx.doi.org/10.46421/entac.v19i1.2008.

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Esse trabalho investiga as condições de conforto térmico na habitação de baixa renda, com foco nas intervenções dos moradores na edificação e as ações adaptativas. A pesquisa de campo compreendeu entrevista semiestruturada com residentes e monitoramento de variáveis térmicas. Quatro tipos arquitetônicos foram analisados, sendo 156 habitações. Vivendo em alto desconforto térmico (4 - 5,5° C acima da temperatura recomendada), os padrões de vida ficam comprometidos devido a modificações realizadas sem orientação técnica associadas a janelas e portas disfuncionais de baixa qualidade. Aos moradores restam estratégias adaptativas como: uso constante de ventiladores, dormir na sala, permanecer no exterior da habitação.

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Тимофеева, Т. П. "THE TOMB OF THE NATIVITY MONASTERY IN THE COLLECTION OF GSMZ". W Археология Владимиро-Суздальской земли. Crossref, 2019. http://dx.doi.org/10.25681/iaras.2019.978-5-94375-304-6.153-168.

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В статье выясняется происхождение белокаменной гробницы из Владимиро-Суздальского музея-заповедника, которая приписывалась святому князю Александру Невскому. Поместиться в ней мог только человек, рост которого не превышал 156 см. Князь, согласно Житию, составленному через 20 лет после его смерти, отличался высоким ростом. Его первоначальное погребение находилось в соборе Рождественского монастыря г. Владимира. В «Описании древних гробниц» первой половины XVII в. в соборе упоминаются, кроме Александра Невского, еще три погребения неизвестных лиц. По описям XIX в., после переноса мощей святого в 1723 г. в Петербург о них напоминала только решетка в форме гроба. В 1930 г. при сносе собора, перестроенного в XIX в., под его фундаментом обнаружились 4 белокаменные гробницы. Одна из них оказалась во Владимирском музее. На фотографии, хранящейся в музее, запечатлена гробница из Рождественского собора с останками человека. Именно в ней можно предполагать мнимую гробницу Александра Невского. The article reveals the origin of the white stone tomb from the Vladimir-Suzdal Museum-reserve, which was attributed to the Holy Prince Alexander Nevsky. It could only fit a man whose height did not exceed 156 cm Prince, according to the Life, compiled 20 years after his death, was of high growth. His initial burial was in the Cathedral of the Nativity monastery of Vladimir. In the “Description of ancient tombs” the first half of the XVII century in the Cathedral are mentioned, in addition to Alexander Nevsky, the three burials of unknown persons. According to descriptions of the nineteenth century, after the transfer of the relics of the Saint in 1723 in Petersburg, they resembled only a lattice in the shape of a coffin. In 1930, during the demolition of the Cathedral, rebuilt in the XIX century, 4 white-stone tombs were found under its Foundation. One of them was in the Vladimir Museum. The photo, stored in the Museum, shows the tomb of the Nativity Cathedral with the remains of a man. It is possible to assume the imaginary tomb of Alexander Nevsky in it.

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Potron, G., O. Toupance, C. Droulle, J. Chanard, A. Kher i P. Barbier. "USE OF A LOW MOLECULAR WEIGHT HEPARIN (LMWH) KABI 2165 DURING HAEMODIALYSIS : DETERMINATION OF LOWEST EFFECTIVE DOSE-MEMBRANE DEPENDANT DOSAGE REGIMEN". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643221.

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The L.M.W.H., Kabi 2165 was compared to standard heparin in stable chronic haemodialysis patients in order to determine the lowest effective dose.An initial dose of 1,000 to 2,500 anti-Xa units followed by an additional dose of 750 to 1,500 anti-Xa units, 1 or 2 hours after the start of the c’alysis was associated with clotting and bleeding complications on 156 dialysis performed in 8 patients: 33 partial coagulations of extracorporeal circulation and 16 minor bleeding events. This dosage regimen corresponds to half of that of standard heparin needed in the same patients to prevent clinical problems.In 9 patients treated with haemodialysis for 4 hours or less using cuprophane membrane, a single dose of 80 anti-Xa units/kg given at the start of dialysis achieved a sufficient antithrombotic effect on 195 dialysis, but minor bleeding complications were observed in 4 cases.On 270 dialysis perfomed in 12 patients using polyacrylonitrile membrane, it was necessary to increase by 1,000 anti-Xa units this previous dosage to obtain satisfactory effectiveness.The biological activities measured in this study indicates that : rises in fibrinopeptide A and platelet factor 4 were associated with clotting in the extracorporeal circulation.Increased levels of factors VIII : RAg and decreased levels of prekal1ierein in the predialysis blood sanples were corrected by Kabi 2165.In conclusion, Kabi 2165 would appear to be an effective and easier antithrombotic agent in patients on chronic haemodialysis.

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Wayne, W. Scott, Ryan A. Barnett, Jeffrey M. Cutright i Ted E. Stewart. "On-Site Emissions and Fuel Consumption Measurement to Compare Locomotive Fuel Injector Performance". W ASME 2006 Internal Combustion Engine Division Fall Technical Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/icef2006-1522.

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As part of the Norfolk-Southern Railroad’s on-going investigation into fuel consumption reductions for their fleet of 3000 locomotives, the Center for Alternative Fuels, Engines and Emissions at West Virginia University conducted on-site locomotive engine performance and emissions measurements to characterize the performance, fuel consumption and emissions associated with fuel injectors from two injector suppliers. Emissions and fuel consumption were measured using the West Virginia University Transportable Locomotive Emissions Testing Laboratory, which was set up at the Norfolk-Southern Heavy Repair Facility in Roanoke, Virginia. The tests were conducted to evaluate potential emissions and fuel consumption differences between two fuel injector suppliers using an EMD GP38-2 locomotive equipped with a 2100 hp (1566 kW), 16-cylinder, EMD 16-645E engine. The test locomotive engine was freshly overhauled and certified to the EPA locomotive Tier 0 emissions standards. Emissions and fuel consumption measurements were conducted according to the Federal Test Procedures defined in the Code of Federal Regulations 40CFR Part 92 Subpart B [1]. The engine was first tested in the “as overhauled” configuration with the OEM fuel injectors to establish the baseline emissions and fuel consumption. The baseline FTP results confirmed that this locomotive was in compliance with the Federal Tier 0 emissions standards. The OEM specification fuel injectors were replaced with “Fuel Saver” injectors designed and manufactured by an aftermarket injector supplier referred to in this paper as Supplier B. The Supplier B injectors reduced fuel consumption on the average of 2–4% for each notch, except for Notch 4 and Low Idle. However, the Supplier B injectors increased the NOx levels by 20–30% for almost every notch, which is an expected result due to the improved combustion efficiency.

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Mease, PJ, H. Marzo-Ortega, A. Poder, F. Van den Bosch, J. Wollenhaupt, E. Lespessailles, M. McIlraith, L. Teng i S. Hall. "FRI0512 Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with long-term (156-week) improvements in basdai in psoriatic arthritis patients: pooled results from 3 phase iii, randomized, controlled trials". W Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3299.

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Raporty organizacyjne na temat "Or 4-1561"

Idárraga-Ortiz, Sergio Alejandro, Martha Cervantes Díaz i Viviana Marcela Vargas Leal. Modalidades y tecnologías de enseñanza en la educación superior: ejercicio cienciométrico y de minería de texto. Universidad Santo Tomás, lipiec 2023. http://dx.doi.org/10.15332/li.ivt.2023.000019.

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En la actualidad, las Instituciones de Educación Superior (IES) asumen un importante reto en relación con los Objetivos de Desarrollo Sostenible, en especial con relación al objetivo 4 denominado Educación de Calidad; para que la oferta educativa de las IES sea oportuna y responda a las necesidades del entorno es necesario adoptar las nuevas modalidades de enseñanza-aprendizaje y las nuevas tecnologías que impulsen una reforma educativa que propenda por la promoción del conocimiento en las nuevas realidades. En Colombia, las instituciones de educación superior compiten con la oferta nacional e internacional, por ello es crucial identificar las tendencias educativas y los referentes en modalidades de formación y métodos de enseñanza en la Educación superior, para ello se desarrolló un ejercicio de vigilancia tecnológica con aplicación de análisis bibliométrico y minería de textos que arrojó los siguientes resultados: se puede observar una tendencia creciente en la divulgación de los trabajos de investigación, en los que 2020 y 2021 son los años de mayor actividad científica, coincidiendo estos con la pandemia del COVID-19, la tasa de crecimiento anual (2010 -2022) fue de 23,35% con un R² = 0,9912; la mayoría de las publicaciones se ubican en las Ciencias sociales (32%), seguido por las Ciencias computacionales (29%), ingeniería (12%), medicina (5%) y matemáticas (4%); los países líderes en esta producción son Estados Unidos produjo 3413 (15,07%), seguido por el Reino Unido con 1894 (8,36%), España con 1762 (7,78%) y China con 1567 (6,92%), a nivel latinoamericano, Brasil aportó 471 (2,08%) documentos, seguido por México con 310 (1,37%), Colombia con 194 (0,86%), Ecuador con 156 (0,69%); del análisis de términos clave se resaltan el e-learning y online learning como las modalidades con mayor abordaje por parte de los investigadores. Por otra parte, a partir de la identificación de la oferta de la Universidad Santo Tomás seccional Bucaramanga se realizaron análisis cienciométricos específicos para las áreas de conocimiento relacionadas con cada división académica, con lo cual se identificaron las instituciones líderes en innovación educativa a nivel global y de Latinoamérica. Finalmente se realizó una revisión de las tendencias en metodologías de enseñanza y aprendizaje de las que se destacan con mayor interés la implementación de e-learning, metodologías híbridas con presencialidad flexible, la formación a través de microcredenciales y la necesidad de adoptar las tecnologías de la educación 4.0, tales como el Big data, la inteligencia artificial, la robótica y el Internet de las Cosas (IoT).

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Clausen, Jay, Michael Musty, Anna Wagner, Susan Frankenstein i Jason Dorvee. Modeling of a multi-month thermal IR study. Engineer Research and Development Center (U.S.), lipiec 2021. http://dx.doi.org/10.21079/11681/41060.

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Inconsistent and unacceptable probability of detection (PD) and false alarm rates (FAR) due to varying environmental conditions hamper buried object detection. A 4-month study evaluated the environmental parameters impacting standoff thermal infra-red(IR) detection of buried objects. Field observations were integrated into a model depicting the temporal and spatial thermal changes through a 1-week period utilizing a 15-minute time-step interval. The model illustrates the surface thermal observations obtained with a thermal IR camera contemporaneously with a 3-d presentation of subsurface soil temperatures obtained with 156 buried thermocouples. Precipitation events and subsequent soil moisture responses synchronized to the temperature data are also included in the model simulation. The simulation shows the temperature response of buried objects due to changes in incoming solar radiation, air/surface soil temperature changes, latent heat exchange between the objects and surrounding soil, and impacts due to precipitation/changes in soil moisture. Differences are noted between the thermal response of plastic and metal objects as well as depth of burial below the ground surface. Nearly identical environmental conditions on different days did not always elicit the same spatial thermal response.

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Rempel, K. U., A. E. Williams-Jones i K. Fuller. An experimental investigation of the solubility and speciation of uranium in hydrothermal ore fluids. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328995.

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Experimental data on the solubility and speciation of uranium in hydrothermal solution is required to improve genetic models for the formation of ore deposits, yet very few data of this type have been published. Of particular interest is the oxidation state of the uranium in solution, as conventional wisdom suggests that U is dissolved in the oxidized U(VI) state and precipitated as reduced U(IV) minerals, yet recent experiments have shown ppm-level solubility for U(IV). This study investigated the mobility of reduced U(IV) and oxidized U(VI) in acidic (pH = 2), fluoride- bearing and alkaline (pH = 10), chloride-bearing solutions at 100-200°C and 1 to 15.8 bars (0.1-1.58 MPa). Preliminary data for the mobility of U(IV) in pH 2 fluids with 0.01 m F- show concentrations of 1.76 to 3.92 ppm U at 200°C, indicating that, contrary to common belief, the reduced U(IV) can be transported in solution. We have also conducted experiments on U(VI) solubility in pH 2 fluoride-bearing, and pH 10 chloride-bearing solutions. Uranium concentrations in the F- -bearing experiments ranged from 624 to 1570 ppm (avg. 825 ppm, n = 6) at 100°C, 670 to 1560 ppm (avg. 931 ppm, n = 4) at 150°C, and 3180 to 7550 ppm (avg. 5240, n = 9) at 200°C. In comparison, U concentrations in the Cl- -bearing runs range from 86.1 to 357 ppm (avg. 185 ppm, n = 15) at 200°C. Clearly, oxidized U(VI) is very readily mobilized in hydrothermal fluids. However, the measured concentrations of U(VI) are independent of those of F- or Cl-, suggesting the formation of U oxide or hydroxide species rather than U chlorides or fluorides. These experimental data will be verified and supplemented in future experiments, which will be used to derive the stoichiometry and thermodynamic constants for the dominant uranium species in hydrothermal solutions. The data from this study will then be integrated into a comprehensive genetic model for uranium ore-forming systems.

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McPheeters, Melissa, Elizabeth A. O'Connor, Sean Riley, Sara M. Kennedy, Christiane Voisin, Kaitlin Kuznacic, Cory P. Coffey, Mark Edlund, Georgiy Bobashev i Daniel E. Jonas. Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review. Agency for Healthcare Research and Quality (AHRQ), listopad 2023. http://dx.doi.org/10.23970/ahrqepccer262.

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Background. Unhealthy alcohol use is the third leading preventable cause of death in the United States, accounting for more than 140,000 deaths annually. Only 0.9 percent of Americans who reported having alcohol use disorder (AUD) in the past year indicated they received medication-assisted AUD treatment. Methods. We updated a 2014 Agency for Healthcare Research and Quality (AHRQ) report on pharmacotherapy for AUD treatment, following AHRQ Evidence-based Practice Center Guidance. We assessed efficacy and comparative effectiveness of specific medications for improving consumption outcomes (Key Question [KQ] 1) and health outcomes (KQ 2). We assessed harms (KQ 3) and sought to identify evidence for the use of pharmacotherapy to treat AUD in primary care (KQ 4) and among subgroups (KQ 5). When possible, we conducted quantitative analyses using random-effects models to estimate pooled effects. When quantitative analyses could not be conducted, we used qualitative approaches. Results. We included 118 studies (156 articles) in our review, which included 81 studies (106 articles) from the 2014 review and 37 studies (50 articles) published since then. Studies generally included counseling co-interventions in all study groups, and the benefits observed reflect the added benefit of medications beyond those of counseling and placebo. Oral naltrexone at the 50 mg dosage had moderate strength of evidence (SOE) for reducing return to any drinking, return to heavy drinking, percent drinking days, and percent heavy drinking days. The addition of a new randomized controlled trial of injectable naltrexone conducted in a population experiencing homelessness resulted in positive outcomes for a reduction in drinking days and heavy drinking days with low SOE. Acamprosate had moderate SOE for a significant reduction in return to any drinking and reduction in drinking days. Topiramate had moderate SOE for several outcomes as well, but with greater side effects. Two other medications demonstrated low SOE for benefit in at least one consumption outcome—baclofen (reduced return to any drinking) and gabapentin (reduced return to drinking and to heavy drinking). With no new studies on disulfiram, there remains inadequate evidence for efficacy compared to placebo for preventing return to any drinking or for other alcohol consumption outcomes. No new eligible studies provided head-to-head comparisons. Conclusions. Oral naltrexone at the 50 mg dose had moderate strength of evidence across multiple outcomes and relative ease of use as a once-daily oral medication. Acamprosate and topiramate also have moderate evidence of benefit with a less desirable side effect profile (topiramate) and a higher pill burden (acamprosate). Clinicians and patients may want to consider which treatment outcomes are most important when choosing among the medications. Current data are largely insufficient for understanding health outcomes. Finally, there is relatively little research to assess the use of medications for AUD among subgroups (9 studies) or in primary care settings (1 study).

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