Rozprawy doktorskie na temat „Olfactory system”
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Clark, Stephen. "Aging in the mammalian olfactory system /". View online, 2009. http://repository.eiu.edu/theses/docs/32211131566906.pdf.
Pełny tekst źródłaFarivar, Shabnam Sarah Laurent Gilles. "Cytoarchitecture of the locust olfactory system /". Diss., Pasadena, Calif. : California Institute of Technology, 2005. http://resolver.caltech.edu/CaltechETD:etd-04212005-143332.
Pełny tekst źródłaPascarella, Giovanni. "Targeting the complexity of mouse olfactory system". Doctoral thesis, SISSA, 2008. http://hdl.handle.net/20.500.11767/4677.
Pełny tekst źródłaMillman, Daniel Joseph. "Emergence of Reward Coding in the Olfactory System". Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493347.
Pełny tekst źródłaMedical Sciences
Prieto, Godino Laura Lucía. "Embryonic development of the olfactory system in Drosophila melanogaster". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609400.
Pełny tekst źródłaChe, Harun Fauzan Khairi. "Mimicking the human olfactory system : a portable e-mucosa". Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3130/.
Pełny tekst źródłaHawkins, Sara Joy. "The timing of regeneration in the amphibian olfactory system". Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15444.
Pełny tekst źródłaComprehending the mechanisms that make lifelong neurogenesis possible has a clear interest for the better understanding of the basic principles that govern cellular and molecular interactions in the nervous system, as well as a relevant clinical interest. The limited ability of the central nervous system to generate new neurons in order to replace those that have been lost is a formidable obstacle to recovery from neuronal damage caused by injury or neurodegenerative disease. The olfactory system (OS) is an ideal system to study the process of neuronal recovery after injury, as it is known for its lifelong capacity to replenish cells lost during natural turnover, as well as its remarkable ability to regenerate after severe lesion. The olfactory epithelium (OE) shows neurogenesis throughout life. Newly differentiated olfactory receptor neurons (ORNs) are continuously reintegrated into an existing circuitry to maintain the sense of smell. The aim of this thesis is to describe the morphological and functional alterations that occur over time in the OS of larval Xenopus laevis, after transection of the olfactory nerve (ON). Results obtained using immunohistochemistry essays, as well as sensory neuron labeling and calcium imaging techniques, indicate that ORN cell death reaches its peak 48 hours after transection, and that proliferating stem cells found in the basal cell layer of the OE are quickly upregulated after lesion. Supporting cells seem to maintain both morphological and functional integrity after transection of the ON. The OE recovers its original morphological structure 1 week after transection, at which time the first axons reach the olfactory bulb (OB) and begin the process of reinnervation. Spontaneous activity of mitral/tufted cells occurs in the OB during the first weeks after transection but no odor-induced activity is observed. After 3-4 weeks glomerular responses were observed in some animals upon application of stimulus, but the response and glomerular morphology are clearly altered as compared to control. After 6-7 weeks responses seem to have fully recovered, indicating that the OS of larval X. laevis recovers morphologically and functionally 6-7 weeks after ON transection.
O estudo dos mecanismos responsáveis pela neuro-regeneração tem um marcado interesse para a compreensão dos princípios básicos que governam as interações celulares e moleculares no sistema nervoso, bem como um interesse clínico relevante. A limitada capacidade do sistema nervoso central para dar origem a novos neurónios é um obstáculo formidável para a recuperação do sistema após lesão neuronal ou doença neurodegenerativa. O sistema olfativo é um sistema ideal para o estudo do processo de recuperação após lesão neuronal, pois é conhecido no mundo científico pela sua capacidade contínua e vitalícia para repor células perdidas durante a renovação celular natural, bem como a sua notável capacidade para regenerar após uma lesão grave. O epitélio olfativo apresenta a capacidade para dar origem a novos neurónios ao longo de toda a vida. Neurónios sensoriais olfativos diferenciados são continuamente reintegrados num circuito já existente, mantendo assim o sentido do olfato. O objetivo desta tese é descrever as alterações morfológicas e funcionais que ocorrem ao longo do tempo no sistema olfativo de Xenopus laevis em estado larvar, após o corte do nervo olfativo. Os resultados obtidos através do uso de ensaios de imunohistoquímica, bem como técnicas de marcação neuronal sensorial e de imagiologia de cálcio, indicam que a morte celular na população de neurónios sensoriais olfativos atinge o seu máximo 48 horas após a lesão, e que células estaminais encontradas na camada basal do epitélio olfativo são positivamente reguladas após lesão e proliferam rapidamente. Células de suporte parecem manter tanto a integridade morfológica como funcional após o corte do nervo olfativo. O epitélio olfativo recupera a sua estrutura morfológica inicial 1 semana após a lesão, momento em que os primeiros axónios atingem o bolbo olfativo e começam o processo de reintegração. Ocorre atividade espontânea das células mitrais/tufados do bolbo olfativo durante as primeiras semanas após a lesão, mas nenhuma atividade induzida por estímulo com odor foi observada. Depois de 3-4 semanas, atividade glomerular foi observada em alguns animais após a aplicação de estímulos, mas a resposta e morfologia glomerular foram claramente alteradas em relação ao controlo. Depois de 6-7 semanas as respostas parecem ter recuperado totalmente, indicando que o sistema olfativo de X. laevis em estado larvar recupera morfológica e funcionalmente 6-7 semanas após o corte do nervo olfativo.
Lee, Mary Elizabeth. "Axon growth and neuron-glia interactions in the olfactory system /". Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/5684.
Pełny tekst źródłaSinding, Charlotte, François Valadier, Viviana Al-Hassani, Gilles Feron, Anne Tromelin, Ioannis Kontaris i Thomas Hummel. "New determinants of olfactory habituation". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-227051.
Pełny tekst źródłaLim, Jung-Eun Jane. "INVESTIGATING THE ROLE OF NEUROGLIAN IN OLFACTORY RECEPTOR AXON PATHFINDING IN THE DEVELOPING OLFACTORY SYSTEM OF DROSOPHILA MELANOGASTER". Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192534.
Pełny tekst źródłaTucker, Eric S. "Dynamic interactions between olfactory receptor axons and glial cells from the olfactory system of the moth Manduca sexta". Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280217.
Pełny tekst źródłaSandström, Malin. "Early Information Processing in the Vertebrate Olfactory System : A Computational Study". Licentiate thesis, KTH, Numerical Analysis and Computer Science, NADA, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4408.
Pełny tekst źródłaThe olfactory system is believed to be the oldest sensory system. It developed to detect and analyse chemical information in the form of odours, and its organisation follows the same principles in almost all living animals - insects as well as mammals. Likely, the similarities are due to parallel evolution - the same type of organisation has arisen more than once. Therefore, the olfactory system is often assumed to be close to optimally designed for its tasks. Paradoxically, the workings of the olfactory system are not yet well known, although several milestone discoveries have been made during the last decades. The most well-known is probably the disovery of the olfactory receptor gene family, announced in 1991 by Linda Buck and Richard Axel. For this and subsequent work, they were awarded a Nobel Prize Award in 2004. This achievement has been of immense value for both experimentalists and theorists, and forms the basis of the current understanding of olfaction. The olfactory system has long been a focus for scientific interest, both experimental and theoretical. Ever since the field of computational neuroscience was founded, the functions of the olfactory system have been investigated through computational modelling. In this thesis, I present the basis of a biologically realistic model of the olfactory system. Our goal is to be able to represent the whole olfactory system. We are not there yet, but we have some of the necessary building blocks; a model of the input from the olfactory receptor neuron population and a model of the olfactory bulb. Taking into account the reported variability of geometrical, electrical and receptor-dependent neuronal characteristics, we have been able to model the frequency response of a population of olfactory receptor neurons. By constructing several olfactory bulb models of different size, we have shown that the size of the bulb network has an impact on its ability to process noisy information. We have also, through biochemical modelling, investigated the behaviour of the enzyme CaMKII which is known to be critical for early olfactory adaptation (suppression of constant odour stimuli).
Luktsystemet anses allmänt vara det äldsta sensoriska systemet. Det utvecklades för att upptäcka och analysera kemisk information i form av lukter, och det är organiserat efter samma principer hos nästan alla djurarter: insekter så väl som däggdjur. Troligen beror likheterna på parallell evolution -- samma organisation har uppstått mer än en gång. Därför antas det ofta att luktsystemet är nära optimalt anpassat för sina arbetsuppgifter. Paradoxalt nog är luktsystemets arbetssätt ännu inte väl känt, även om flera banbrytande framsteg gjorts de senaste decennierna. Det mest välkända är nog upptäckten av genfamiljen av luktreceptorer, som tillkännagavs 1991 av Linda Buck och Rikard Axel. För detta och efterföljande arbete belönades de med Nobelpriset år 2004. Upptäckten har varit mycket värdefull för både experimentalister och teoretiker, och formar grunden för vår nuvarande förståelse av luktsystemet. Luktsystemet har länge varit ett fokus för vetenskapligt intresse, både experimentellt och teoretiskt. Ända sedan fältet beräkningsbiologi grundades har luktsystemet undersökts genom datormodellering. I denna avhandling presenterar jag grunden för en biologiskt realistisk modell av luktsystemet. Vårt mål är att kunna representera hela luktsystemet. Så långt har vi ännu inte nått, men vi har några av de nödvändiga byggstenarna: en modell av signalerna från populationen av luktreceptorceller, och en modell av luktbulben. Genom att ta hänsyn till nervcellernas rapporterade variationer i geometriska, elektriska och receptor-beroende karaktärsdrag har vi lyckats modellera svarsfrekvenserna från en population av luktreceptorceller. Genom att konstruera flera olika stora modeller av luktbulben har vi visat att storleken på luktbulbens cellnätverk påverkar dess förmåga att behandla brusig information. Vi har också, genom biokemisk modellering, undersökt beteendet hos enzymet CaMKII, som är kritiskt viktigt för adaptering (undertryckning av ständigt närvarande luktstimuli) i luktsystemet.
Vukovic, Jana. "An in vitro and in vitro study on the role of the glycoprotein fibulin-3 in olfactory nerve growth and repair". University of Western Australia. School of Anatomy and Human Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0182.
Pełny tekst źródłaFranceschini, Isabelle A. "Cellular and molecular studies on olfactory bulb ensheathing cells". Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301803.
Pełny tekst źródłaPersson, Eva. "Bioactivation and transport of foreign materials in the olfactory system /". Uppsala : Dept. of Pharmacology and Toxicology, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/v145.pdf.
Pełny tekst źródłaGhaninia, Majid. "Olfaction in mosquitoes : neuroanatomy and electrophysiology of the olfactory system /". Alnarp : Dept. of Plant Protection Biology, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200793.pdf.
Pełny tekst źródłaIsles, Anthony Roger. "Investigations of parent of origin effects in the olfactory system". Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621562.
Pełny tekst źródłaJansson, Björn. "Models for the transfer of drugs from the nasal cavity to the central nervous system /". Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905.
Pełny tekst źródłaDahlin, Maria. "Nasal administration of compounds active in the central nervous system : Exploring the olfactory system". Doctoral thesis, Uppsala University, Department of Pharmacy, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-545.
Pełny tekst źródłaThe nasal administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly absorbed through the nasal mucosa, resulting in a rapid onset of action, and also avoiding degradation in the gastrointestinal tract and first-pass metabolism in the liver. The olfactory receptor cells, which are in direct contact with both the environment and the central nervous system (CNS), are potential routes for drugs into the CNS. The olfactory pathway thus circumvents the blood brain barrier (BBB) which prevents many systemically administered drugs from entering the brain.
The studies used compounds active in the CNS and the experiments were performed in rodents. The nasal bioavailability of (S)-UH-301, NXX-066 and [3H]-dopamine was investigated in a rat model; uptake into the cerebrospinal fluid (CSF) was compared after nasal and intravenous administration. The concentrations of S-UH-301 and NXX-066 in plasma and CSF were measured with high performance liquid chromatography. The possible transfer of dopamine and neurotensin along the olfactory pathway after nasal administration to mice was studied using brain tissue sampling and autoradiography. The radioactivity content in blood, CSF and dissected brain tissue samples after administration of [3H]-dopamine and [3H]-neurotensin was assessed using liquid scintillation, and thin layer chromatography (TLC) was used to investigate the metabolic fate of [3H]-dopamine.
The results of this thesis suggest that nasal administration of CNS-active compounds with low oral bioavailability is an interesting and workable alternative to intravenous injection. The small lipophilic compounds (S)-UH-301 and NXX-066 were rapidly and completely absorbed after nasal administration, although hard evidence of direct transfer from the nose remains elusive. Radioactivity measurements in the olfactory bulb following nasal administration of
[3H]-dopamine and [3H]-neurotensin indicate that transfer occurred. The TLC results showed the presence of unchanged dopamine in the olfactory bulb but it is less clear from initial results with neurotensin, which radioactive products of this molecule reached the olfactory bulb, and further studies are required.
Sandström, Malin. "Computational Modelling of Early Olfactory Processing". Doctoral thesis, KTH, Beräkningsbiologi, CB, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12090.
Pełny tekst źródłaDetektion av kemiska ämnen anses allmänt vara den äldsta sensoriska förmågan. De kemiska sinnena, lukt och smak, utvecklades för att upptäcka och analysera kemisk information i form av luft- eller vattenburna ämnen, för att hitta mat och partners, och för att undvika fara. Luktsystemet är organiserat efter samma principer hos nästan alla djurarter, insekter såväl som däggdjur. Troligen beror likheterna på parallell evolution – samma organisation verkar ha uppstått mer än en gång. Därför antas det ofta att luktsystemet är nära optimalt anpassat för sina arbetsuppgifter.Paradoxalt nog är luktsystemets arbetsprinciper ännu inte väl kända, även om flera banbrytande framsteg gjorts de senaste decennierna. Det mest välkända är nog upptäckten av genfamiljen av luktreceptorer, som tillkännagavs 1991 av Linda Buck och Rikard Axel. För detta och efterföljande arbete belönades de med Nobelpriset år 2004. Upptäckten har varit mycket värdefull för både experimentalister och teoretiker, och är grunden för vår nuvarande förståelse av luktsystemet. Luktsystemet har länge varit ett fokus för vetenskapligt intresse inom flera fält, experimentella såväl som teoretiska, och har ofta använts som ett modellsystem. Och ända sedan fältet beräkningsneurobiologi grundades har luktsystemet undersökts genom datormodellering. I denna avhandling presenterar jag flera ansatser till biologiskt realistiskaberäkningsmodeller av luktsystemet, med tonvikt på de tidigare delarna av ryggradsdjurens luktsystem – luktreceptorceller och luktbulben. Jag har undersökt beteendet hos enzymet CaMKII, som anses vara kritiskt viktigt för adaptation (undertryckning av ständigt närvarande luktstimuli) i luktsystemet, i en biokemisk modell. Genom att konstruera flera olika stora modeller av luktbulben har jag visat att storleken på luktbulbens cellnätverk påverkar dess förmåga att behandla brusig information. Genom att ta hänsyn till nervcellernas rapporterade variationer i geometriska, elektriska och receptor-beroende karaktärsdrag har jag lyckats modellera svarsfrekvenserna från en population av luktreceptorceller. Jag har använt denna modell för att hitta de nyckelprinciper som styr huvuddelen av luktreceptorneuron-populationens svar, ochundersökt några av de tänkbara konsekvenserna av dessa nyckelprinciper i efterföljande studier av luktreceptorneuron-populationen och luktbulben – det vi kallar ”fuzzy concentration coding”-hypotesen.
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Raman, Baranidharan. "Sensor-based machine olfaction with neuromorphic models of the olfactory system". Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/4984.
Pełny tekst źródłaSandström, Malin. "Early information processing in the vertebrate olfactory system : a computational study /". Stockholm : Numerisk analys och datalogi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4408.
Pełny tekst źródłaTallkvist, Jonas. "Nickel permeation pathways in the small intestine and the olfactory system /". Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1997. http://epsilon.slu.se/avh/1997/91-576-5422-0.gif.
Pełny tekst źródłaAuffarth, Benjamin. "Machine Learning Techniques with Specific Application to the Early Olfactory System". Doctoral thesis, KTH, Beräkningsbiologi, CB, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-90474.
Pełny tekst źródłaQC 20120224
Dubuque, Suzanne Hope. "Tyrosine kinase activity in the developing olfactory system of Manduca sexta". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282786.
Pełny tekst źródłaYarid, Colin R., Rudy T. Chapman i Diego J. Rodriguez-Gil. "Maturation and synapse formation of olfactory sensory neurons after injury". Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/94.
Pełny tekst źródłaKaplan, Bernhard. "Modeling prediction and pattern recognition in the early visual and olfactory systems". Doctoral thesis, KTH, Beräkningsbiologi, CB, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-166127.
Pełny tekst źródłaQC 20150504
Cameron, Nicholas John. "Developing Olfactory Ensheathing Cells for ex vivo Delivery of GDNF". Thesis, Griffith University, 2010. http://hdl.handle.net/10072/365205.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
Full Text
Amaya, Daniel Alejandro. "Integration of the Peripheral and Central Nervous System During Development of the Murine Olfactory Nerve". Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367158.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
Hoare, Derek J. "Olfactory coding in a simple neural system : integrative processes and behavioural outputs". Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493945.
Pełny tekst źródłaSpice, Rachel Helen. "The molecular basis of thiol odorant sensitivity in the mammalian olfactory system". Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406662.
Pełny tekst źródłaBroome, Bede Michael Konishi Masakazu. "Population coding and reconstruction of complex stimuli in the locust olfactory system /". Diss., Pasadena, Calif. : Caltech, 2006. http://resolver.caltech.edu/CaltechETD:etd-03142006-171138.
Pełny tekst źródłaCassenaer, Stijn Laurent Gilles Konishi Masakazu. "Spike-timing dependent plasticity and synchronous oscillations in an invertebrate olfactory system /". Diss., Pasadena, Calif. : California Institute of Technology, 2008. http://resolver.caltech.edu/CaltechETD:etd-12202007-160330.
Pełny tekst źródłaWeiss, Lukas [Verfasser]. "Information processing in the olfactory system of different amphibian species / Lukas Weiss". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1218780711/34.
Pełny tekst źródłaSwiergiel, Jennifer Joan. "Expression of Pax-6 in the developing olfactory system of Xenopus laevis". Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187103.
Pełny tekst źródłaPENNAZZA, GIORGIO. "SAMPLING AND SENSING STRATEGIES FOR NOVEL APPLICATIONS WITH AN ARTIFICIAL OLFACTORY SYSTEM". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2005. http://hdl.handle.net/2108/177.
Pełny tekst źródłaEveryday, everyone of us uses the five senses, very often without consciousness at all of using them, but simply exploiting the results. The results consist in an interpretation of the real world around us. Olfaction is probably one of the senses humans have lost potentiality to exploit during evolution, but odour is a very important source of data, because of the power of synthesis of a lot of interactions and parameters we are not able to collect, read and elaborate at the same time. An existing technology, the Electronic Nose of the Sensors and Microsystems Group of the University of Rome ‘Tor Vergata’, is the objective of this Thesis. The aim is to ask fundamental questions about it, and by studying the possible solutions, reach the whole system improvement. The great potentialities of artificial olfactory systems can be exploited in many fields. This multidisciplinary range of applications asks for designing of dedicated sampling systems depending on the different scope. Although the working principle and the sensitive material are the basis on which these devices are developed, the sampling, within the measure chain, is a fundamental step to optimize the whole system performances. According to these considerations the best way for designing “ad hoc“ experimental set is to specialize a specific sampling procedure for each application. In this thesis three different studies are considered: medical and environmental applications, and odour sampling in static conditions. In particular, the experience of the six years of experiments dedicated to lung cancer study by mean of e-nose breath analysis is illustrated.
Borowski, Peter. "Stochastic dynamics in olfactory signal transduction and development". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1159519135136-22697.
Pełny tekst źródłaDie Sinne der Tiere (und Menschen) dienen dazu, Informationen über die Aussenwelt in neuronale, ' interne' Information zu 'übersetzen'. Im Falle des Geruchssinns sind dies Informationen über die Art und Konzentration von Geruchsstoffen. In den letzten 15 Jahren wurden grosse Fortschritte im experimentellen Verständnis der ersten beiden Stufen des Geruchssinns gemacht, sowohl was die Signaltransduktion in den Zilien der Geruchszellen betrifft, als auch bezüglich der ersten 'Schaltstelle' im Gehirn, dem olfaktorischen Bulbus (sowie in der Verbindung dieser beiden Stufen). Die Entwicklung theoretischer Studien, die die experimentell gewonnenen Daten klassifizieren können, befindet sich dagegen erst am Anfang. Ziel der vorliegenden Arbeit ist es, zum theoretischen Verständnis dieser ersten beiden Stufen beizutragen. Die erste Verarbeitung der olfaktorischen Information, die olfaktorische Signaltransduktion, wird durch ein komplexes chemisches Netzwerk in den Sinneszellen bewerkstelligt. In dieser Dissertation werden Methoden der nichtlinearen Dynamik, kombiniert mit Netzwerktheorie (stöchiometrische Netzwerkanalyse) benutzt, um einen negativen Rückkopplungsmechanismus zu identifizieren, der einige in neuerer Zeit gewonnene experimentelle Ergebnisse erklären kann, u.a. Oszillationen der Kalziumkonzentration oder die Anpassung der Zelle an starke Reize. Bei dieser Rückkopplung handelt es sich um eine experimentell gut bestätigte Hemmung eines Kationenkanals durch den Kalziumkomplex des Proteins Calmodulin. Das Ergebnis der vier gekoppelten nichtlinearen deterministischen Differenzialgleichungen, die das dynamische Verhalten des Systems beschreiben, stimmt quantitativ mit experimentellen Daten überein. Eine Bifurkationsanalyse zeigt die Robustheit der oszillierenden Lösung gegenüber Veränderungen der verwendeten Parameter und macht Vorhersagen möglich, die als experimentelle Tests des vorgeschlagenen Mechanismus dienen können. Eine weitere Abstrahierung der oben beschriebenen Signaltransduktionseinheit führt zu einem stochastischen Zweiniveausystem mit negativer Rückkopplung, das nicht nur in Signalsystemen gefunden werden kann, sondern auch in anderen Bereichen der Zellbiologie. Im Gegensatz zu der oben beschriebenen, komplett deterministischen Beschreibung zeigt das hier betrachtete Modellsystem intrinsisches Rauschen. Der Einfluss der Rückkopplung auf das Rauschen sowie auf die Signalübertragungseigenschaften des Moduls werden detailliert analysiert, indem mit Hilfe verschiedener analytischer Methoden Mittelwerte, Korrelations- und Antwortfunktionen des Systems ausgerechnet werden. Diese Methoden habe alle gemein, dass das intrinsische Rauschen des Systems aus der Dynamik selbst berechnet wird und nicht ' von Hand' eingefügt wird. Um allgemeingültige Ausdrücke für die Mittelwerte zu bekommen, wird eine Mastergleichung aufgestellt und gelöst. Die Korrelations- und Antwortfunktionen werden für schwache Rückkopplung mit Hilfe einer Pfadintegralmethode ausgerechnet, und eine einfachere, selbstkonsistente Methode begrenzter Gültigkeit wird für mögliche Erweiterungen des Systems, z.B. die Berücksichtigung von Diffusion, entwickelt. Die Ergebnisse der verschiedenen analytischen Methoden werden miteinander und mit den Ergebnissen ausführlicher numerischer Simulationen verglichen. Die betrachteten Grössen ermöglichen Aussagen über die Qualität der Signaltransduktion dieses Moduls sowie über die positiven und negativen Effekte der Rückkopplung auf diese. Ein weiteres Beispiel für interessante und von stochastischen Effekten beeinflusste Dynamik findet man einen Schritt weiter in der olfaktorischen Signalverarbeitung: Die während der Entwicklung stattfindende Ausbildung der neuronalen Karte auf der Oberfläche des olfaktorischen Bulbus, der zweiten Stufe des olfaktorischen Systems. Die Dynamik dieser sehr komplexen biologischen Musterbildung wird mittels numerischer Simulationen untersucht, wobei der Schwerpunkt auf drei verschiedene Aspekte axonalen Wachstums gesetzt wird. Die Reaktion axonaler Wachstumskegel auf mögliche chemische Signalstoffe wird verschieden detailliert beschrieben. Es gibt deutliche experimentelle Hinweise auf Wechselwirkung zwischen Axonen, was in den Modellen auf verschiedene Arten implementiert wird. Schliesslich wird die Erneuerung der Axone betrachtet und im vielversprechendsten Modell, in dem viele Axone als wechselwirkende gerichtete random walkers simuliert werden, berücksichtigt und analysiert. Für jeden dieser drei Aspekte können entsprechende experimentelle Ergebnisse qualitativ reproduziert werden
Strauch, Christina [Verfasser], Denise [Akademischer Betreuer] Manahan-Vaughan i Christian [Akademischer Betreuer] Bellebaum. "Exploration of olfactory information processing within different components and associated structures of the olfactory system / Christina Strauch. Gutachter: Denise Manahan-Vaughan ; Christian Bellebaum". Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1099703875/34.
Pełny tekst źródłaBanger, Kulwinder Kaur. "Glutathione S-transferases of the rat nasal cavity". Thesis, Liverpool John Moores University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261475.
Pełny tekst źródłaLai, Sen-Lin. "Neural Diversity in the Drosophila Olfactory Circuitry: A Dissertation". eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/340.
Pełny tekst źródłaTonsor, Michael M. "Interaction of apoE with estrogen in the olfactory system during nerve maintenance and recovery /". View online, 2009. http://repository.eiu.edu/theses/docs/32211131566909.pdf.
Pełny tekst źródłaClark, Jessica. "Effects of Sensory Ablation on the Young and Aged Ventriculo-Olfactory Neurogenic System". Thesis, Griffith University, 2013. http://hdl.handle.net/10072/366315.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
Full Text
Kuijten, M. M. P. "Characterisation of the olfactory system for cell-based therapies to treat neurodegenerative disease". Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1511817/.
Pełny tekst źródłaEckstein, Eugenia [Verfasser], i Frank [Akademischer Betreuer] Zufall. "Trpm4 and Trpm5 in the murine olfactory system / Eugenia Eckstein ; Betreuer: Frank Zufall". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1203128940/34.
Pełny tekst źródłaRawal, Shilpa [Verfasser], i Karl-Friedrich [Akademischer Betreuer] Fischbach. "The role of IRM Protein Kirre in the olfactory system of Drosophila melanogaster". Freiburg : Universität, 2015. http://d-nb.info/1125903732/34.
Pełny tekst źródłaWilliams, Sarah. "The cellular and molecular changes occurring in the degenerating and regenerating olfactory system". Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272844.
Pełny tekst źródłaNemeth, Daniel C. "Evolution of the Coeloconic Sensilla in the Peripheral Olfactory System of Drosophila Mojavensis". University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504798790782263.
Pełny tekst źródłaLogin, Hande. "Activity-regulated retinoic acid signaling in olfactory sensory neurons". Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89022.
Pełny tekst źródłaDannecker, Luiz Eduardo Cabral Von. "Ric-8B, um provável GEF para Galpha-olf, promove expressão funcional de receptores olfatórios". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-18092006-132143/.
Pełny tekst źródłaOdorants are detected by a large family of odorant receptors (ORs) expressed in the olfactory neurons in the nose. The activated receptors couple to an olfactory-specific G-protein (Galphaolf), which activates adenylyl cyclase III to produce cAMP. Increased cAMP levels activate cyclic nucleotide-gated channels, causing cell membrane depolarization. The information provided by the odorant receptors is transmitted to specific regions of the brain leading to odorant perception. The determination of the odorant specificities of the different ORs will contribute to the understanding of how odorants are discriminated by the olfactory system. However, only a few ORs have been linked to odorants they recognized to date because ORs are not efficiently expressed in heterologous cells since they are poorly expressed on the cell surface. Here we used yeast two-hybrid to search for potential regulators for Galphaolf. We found that Ric-8B (for Resistant to Inhibitors of Cholinesterase), a putative GTP exchange factor, is able to interact with Gaolf. Like Gaolf, Ric-8B is predominantly expressed in the mature olfactory sensory neurons and also in a few regions in the brain. The highly restricted and colocalized expression patterns of Ric-8B and Galphaolf strongly indicate that Ric-8B is a functional partner for Galphaolf. We show that Ric-8B is able to potentiate Galphaolf-dependent cAMP accumulation in human embryonic kidney 293 cells and therefore may be an important component for odorant signal transduction. Finally, we show that Ric-8B promotes efficient heterologous expression of ORs. Our results show that Ric-8B enhances accumulation of Galphaolf at the cell cortex, indicating that it promotes functional OR expression probably by improving the efficiency of OR coupling to Galphaolf. Our results demonstrate that the employment of Ric-8B in a high-throughput system will allow the functional screening of the OR family members and thereby provide further insight into the mechanisms of odor perception.
Veleva, Desi. "The Role of Vitamin D on Cell Proliferation in the Olfactory System and the Brain". Thesis, Griffith University, 2010. http://hdl.handle.net/10072/365417.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
Full Text