Gotowe bibliografie tematyczne / Olfactory stem cells

Gotowa bibliografia na temat „Olfactory stem cells”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 19 lutego 2023

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Artykuły w czasopismach na temat "Olfactory stem cells"

Galeano, Carlos, Zhifang Qiu, Anuja Mishra, Steven L. Farnsworth, Jacob J. Hemmi, Alvaro Moreira, Peter Edenhoffer i Peter J. Hornsby. "The Route by Which Intranasally Delivered Stem Cells Enter the Central Nervous System". Cell Transplantation 27, nr 3 (marzec 2018): 501–14. http://dx.doi.org/10.1177/0963689718754561.

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Intranasal administration is a promising route of delivery of stem cells to the central nervous system (CNS). Reports on this mode of stem cell delivery have not yet focused on the route across the cribriform plate by which cells move from the nasal cavity into the CNS. In the current experiments, human mesenchymal stem cells (MSCs) were isolated from Wharton’s jelly of umbilical cords and were labeled with extremely bright quantum dots (QDs) in order to track the cells efficiently. At 2 h after intranasal delivery in immunodeficient mice, the labeled cells were found under the olfactory epithelium, crossing the cribriform plate adjacent to the fila olfactoria, and associated with the meninges of the olfactory bulb. At all times, the cells were separate from actual nerve tracts; this location is consistent with them being in the subarachnoid space (SAS) and its extensions through the cribriform plate into the nasal mucosa. In their location under the olfactory epithelium, they appear to be within an expansion of a potential space adjacent to the turbinate bone periosteum. Therefore, intranasally administered stem cells appear to cross the olfactory epithelium, enter a space adjacent to the periosteum of the turbinate bones, and then enter the SAS via its extensions adjacent to the fila olfactoria as they cross the cribriform plate. These observations should enhance understanding of the mode by which stem cells can reach the CNS from the nasal cavity and may guide future experiments on making intranasal delivery of stem cells efficient and reproducible.

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Wetzig, Andrew, Alan Mackay-Sim i Wayne Murrell. "Characterization of Olfactory Stem Cells". Cell Transplantation 20, nr 11-12 (grudzień 2011): 1673–91. http://dx.doi.org/10.3727/096368911x576009.

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Roisen, F. J., K. M. Klueber, C. L. Lu, L. M. Hatcher, A. Dozier, C. B. Shields i S. Maguire. "Adult human olfactory stem cells". Brain Research 890, nr 1 (styczeń 2001): 11–22. http://dx.doi.org/10.1016/s0006-8993(00)03016-x.

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Ozdener, H., C. Di Poto, N. Rawson, L. K. Pannell i J. N. Baraniuk. "Proteomics of the Olfactory Stem Cells". Journal of Allergy and Clinical Immunology 123, nr 2 (luty 2009): S261. http://dx.doi.org/10.1016/j.jaci.2008.12.1009.

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McDonald, Cameron, Alan Mackay-Sim, Denis Crane i Wayne Murrell. "Could Cells from Your Nose Fix Your Heart? Transplantation of Olfactory Stem Cells in a Rat Model of Cardiac Infarction". Scientific World JOURNAL 10 (2010): 422–33. http://dx.doi.org/10.1100/tsw.2010.40.

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This study examines the hypothesis that multipotent olfactory mucosal stem cells could provide a basis for the development of autologous cell transplant therapy for the treatment of heart attack. In humans, these cells are easily obtained by simple biopsy. Neural stem cells from the olfactory mucosa are multipotent, with the capacity to differentiate into developmental fates other than neurons and glia, with evidence of cardiomyocyte differentiationin vitroand after transplantation into the chick embryo. Olfactory stem cells were grown from rat olfactory mucosa. These cells are propagated as neurosphere cultures, similar to other neural stem cells. Olfactory neurospheres were grownin vitro, dissociated into single cell suspensions, and transplanted into the infarcted hearts of congeneic rats. Transplanted cells were genetically engineered to express green fluorescent protein (GFP) in order to allow them to be identified after transplantation. Functional assessment was attempted using echocardiography in three groups of rats: control, unoperated; infarct only; infarcted and transplanted. Transplantation of neurosphere-derived cells from adult rat olfactory mucosa appeared to restore heart rate with other trends towards improvement in other measures of ventricular function indicated. Importantly, donor-derived cells engrafted in the transplanted cardiac ventricle and expressed cardiac contractile proteins.

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Mollichella, Marie-Laure, Violaine Mechin, Dany Royer, Patrick Pageat i Pietro Asproni. "Isolation and Characterization of Cat Olfactory Ecto-Mesenchymal Stem Cells". Animals 12, nr 10 (17.05.2022): 1284. http://dx.doi.org/10.3390/ani12101284.

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The olfactory mucosa contains olfactory ecto-mesenchymal stem cells (OE-MSCs) which show stemness features, multipotency capabilities, and have a therapeutic potential. The OE-MSCs have already been collected and isolated from various mammals. The aim of this study was to evaluate the feasibility of collecting, purifying and amplifying OE-MSCs from the cat nasal cavity. Four cats were included in the study. Biopsies of olfactory mucosa were performed on anesthetized animals. Then, the olfactory OE-MSCs were isolated, and their stemness features as well as their mesodermal differentiation capabilities were characterized. Olfactory mucosa biopsies were successfully performed in all subjects. From these biopsies, cellular populations were rapidly generated, presenting various stemness features, such as a fibroblast-like morphology, nestin and MAP2 expression, and sphere and colony formation. These cells could differentiate into neural and mesodermal lineages. This report shows for the first time that the isolation of OE-MSCs from cat olfactory mucosa is possible. These cells showed stemness features and multilineage differentiation capabilities, indicating they may be a promising tool for autologous grafts and feline regenerative medicine.

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Murrell, Wayne, François Féron, Andrew Wetzig, Nick Cameron, Karisha Splatt, Bernadette Bellette, John Bianco, Chris Perry, Gabriel Lee i Alan Mackay-Sim. "Multipotent stem cells from adult olfactory mucosa". Developmental Dynamics 233, nr 2 (2005): 496–515. http://dx.doi.org/10.1002/dvdy.20360.

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Sacramento, S., S. Rebelo i O. A. B. da Cruz e Silva. "Olfactory mucosa stem cells differentiate into neuron-like cells". Microscopy and Microanalysis 21, S6 (sierpień 2015): 28–29. http://dx.doi.org/10.1017/s1431927614013816.

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Tomé, Mercedes, Susan L. Lindsay, John S. Riddell i Susan C. Barnett. "Identification of Nonepithelial Multipotent Cells in the Embryonic Olfactory Mucosa". STEM CELLS 27, nr 9 (21.05.2009): 2196–208. http://dx.doi.org/10.1002/stem.130.

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VanHook, Annalisa M. "Inflammation induces stem cell quiescence". Science Signaling 12, nr 605 (29.10.2019): eaaz9665. http://dx.doi.org/10.1126/scisignal.aaz9665.

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Rozprawy doktorskie na temat "Olfactory stem cells"

Wetzig, Andrew R., i n/a. "Olfactory Stem Cells From Adult Rats". Griffith University. School of Biomolecular and Biomedical Science, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070724.121953.

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The formation of neurospheres was important in demonstrating that neurogenesis in the adult brain may be fuelled by a stem cell population. The olfactory mucosa is another site of neurogenesis which, in humans, has been observed to contain a stem cell population through the formation of neurospheres (Murrell et al., 2005). Stem cells can be defined as cells capable of self-renewal and multipotency. The aim of this study was to investigate the potential of rat olfactory stem cells growing as neurospheres. The hypothesis is that the rat olfactory mucosa contains a 'true' stem cell population that can be cultured as neurospheres and that will demonstrate multipotency by differentiating into 'non-olfactory' cell types and possess the capacity for self-renewal, if provided with the appropriate environmental niche. Here it was found that adult rat olfactory mucosa is capable of generating neurospheres when cultured in EGF and bFGF. Evidence of self-renewal was provided by the formation of six generations of neurospheres, the formation of neurospheres from single cells and the expression of markers associated with self-renewal by neurosphere cells. The multipotency of olfactory neurosphere cells was demonstrated through manipulation of the stem cell niche. In defined culture conditions, extracellular matrix molecules and growth factors were able to induce the differentiation of neurosphere cells down the dopaminergic lineage pathway. When co-cultured with differentiating cells, neonatal myoblasts and 3T3-L1 cells, olfactory neurosphere cells were able to differentiate and incorporate into a skeletal muscle myotube and differentiate into adipocytes, respectively. In conclusion it was found that the adult rat olfactory mucosa is capable of generating neurospheres. When presented with an appropriate niche neurosphere cells are able to self-renew and demonstrate multipotency.

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Sacramento, Sónia Raquel Capela. "Establishing model systems from olfactory mucosa stem cells". Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11806.

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Mestrado em Biomedicina Molecular
As células estaminais são uma classe distinta de células, devido às suas capacidades de regeneração e diferenciação em vários tipos de células especializadas. Os nichos onde estas se encontram servem-lhes de sustentação e permitem a sua manutenção num estado indiferenciado, afectando a sua regeneração e diferenciação através de estímulos. As células estaminais dividem-se em duas classes: embrionárias (pluripotentes) e adultas (multipotentes), embora também existam células estaminais pluripotentes induzidas. Nos últimos anos tem-se estudado a possibilidade de utilizar sistemas baseados em células estaminais no estudo de neuropatologias. Assim sendo, os objectivos desta dissertação foram o isolamento e proliferação de células estaminais da mucosa olfactiva, a indução destas células para a formação de neurosferas e a sua diferenciação para células tipo neuronais (NLC) e células derivadas de neurosferas (ONS). Também se procedeu à diferenciação das ONS e à caracterização dos modelos celulares NLC e ONS. Para se atingir os objectivos definidos, foram recolhidas biópsias de mucosa olfactiva e isolaram-se células estaminais de epitélio e da lâmina própria. As células estaminais da mucosa olfactiva proliferaram e foram induzidas a formar neurosferas com um meio de cultura específico (DMEM/F12 com ITS-X, EGF e FGF2). As neurosferas foram posteriormente diferenciadas em células ONS (com meio DMEM/F12) e em NLC (com meio neurobasal suplementado com NGF, B27, glutamina e glutamato). Imagens obtidas durante o tempo de diferenciação das NLC foram analisadas tendo em conta parâmetros morfométricos. As células ONS foram adaptadas à cultura em meio sem soro e diferenciadas em células tipo neurónios (usando meio DMEM/F12 com N2 e meio DMEM/F12 com B27). Os resultados obtidos indicam que estabelecemos culturas primárias de células estaminais da mucosa olfactiva de rato. A eficiência dos protocolos de isolamento e proliferação foi confirmada pela marcação com nestina através de imunofluorescência e pela formação de neurosferas. A análise morfométrica das NLC indicou que diferenciámos as neurosferas para células tipo neuronal, devido à sua morfologia neuronal e à expressão do marcador neuronal β-tubulina III. Foram também estabelecidas culturas de células ONS, posteriormente diferenciadas através da redução de soro, apresentando um fenótipo tipo neuronal quando mantidas em meio definido. Contudo, devem ser realizadas experiências futuras para a caracterização deste novo modelo celular. Os nossos resultados permitem-nos concluir que estabelecemos e caracterizámos novos sistemas modelo baseados em células estaminais. Estes resultados são relevantes uma vez que tais modelos podem ser usados para o estudo de mecanismos celulares e moleculares envolvidos em inúmeras neuropatologias, nomeadamente na Doença de Alzheimer.
Stem cells are a distinct class of cells, characterized by their ability to self-renew and differentiate into several specialized cell types. The niche of stem cells provides them support, favors their existence in an undifferentiated state and affects, by stimuli, their self-renewal and cellular fate. Stem cells can be divided in two broad classes: embryonic (pluripotent) and somatic stem cells (multipotent), although induced pluripotent stem cells are also a reality nowadays. The possibility of investigating neuropathologies using stem cell based systems has attracted interest among researchers in the last few years. Therefore, the main objectives of this dissertation were the isolation and proliferation of olfactory mucosa stem cells that were further induced to form neurospheres and further differentiated into neuron-like cells (NLC) and olfactory neurosphere-derived cells (ONS). ONS differentiation and the characterization of NLC and ONS model systems were also performed. For the accomplishment of these objectives, olfactory mucosa biopsies were collected and epithelium and lamina propria stem cells isolated. The well proliferating olfactory mucosa stem cells were induced to form neurospheres using a specific culture medium (DMEM/F12 supplemented with ITS-X, EGF and FGF2). The neurospheres were then differentiated into ONS cells (using DMEM/F12 medium) and into NLC (using neurobasal medium supplemented with NGF, B27, glutamine and glutamate). Morphometric analysis of neuron-like cells was performed on microphotographs taken at several time points during the differentiation procedure. ONS cells were adapted to serum deprivation and differentiated into neuronal-like cells (using DMEM/F12 with N2 medium and DMEM/F12 with B27 medium). Our results indicate that we successfully established primary rat cultures from olfactory mucosa stem cells. The efficiency of the isolation/proliferation procedure was confirmed by positive immunostaining with stemness marker nestin and also by their ability to form neurospheres. The morphometric analysis of NLC revealed that we successfully differentiated neurosphere-forming cells into neuron-like cells, since they assume a neuronal like phenotype and they highly express the neuronal marker β-tubulin III. Additionally, ONS cultures were established and further differentiated by gradual serum deprivation. In fact, these cells presented neuronal-like phenotypic characteristics when cultured in defined medium. However, additional experiments for characterization of this new model system should be performed. From our results we can conclude that we efficiently established and characterized new stem cells model systems. These results are of paramount importance since they will be used for the study of cellular and molecular mechanisms underlying several neuropathologies, including Alzheimer’s disease

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Wells, Karen Elizabeth. "Characterisation of the stem/precursor cells of the rat olfactory epithelium". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613198.

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Momma, Stefan. "Neural stem cells and their contribution to neurogenesis in the adult mammalian brain /". Stockholm : Karolinska institutet, 2002. http://diss.kib.ki.se/2002/91-7349-324-4/.

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Murdoch, Barbara. "Identification, regulation and lineage tracing of embryonic olfactory progenitors". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/994.

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Neurogenesis occurs in exclusive regions in the adult nervous system, the subventricular zone and dentate gyrus in the brain, and olfactory epithelium (OE) in the periphery. Cell replacement after death or injury, occurs to varying degrees in neural tissue, and is thought to be dependent upon the biological responses of stem and/or progenitor cells. Despite the progress made to identify adult OE and central nervous system (CNS) progenitors and lineage trace their progeny, our spatial and temporal understanding of embryonic OE neuroglial progenitors has been stalled by the paucity of identifiable genes able to distinguish individual candidate progenitors. In the developing CNS, radial glia serve as both neural progenitors and scaffolding for migrating neuroblasts and are identified by the expression of a select group of antigens, including nestin. Here, I show that the embryonic OE contains a novel radial glial-like progenitor (RGLP) that is not detected in adult OE. RGLPs express the radial glial antigens nestin, GLAST and RC2, but not brain lipid binding protein (BLBP), which, distinct from CNS radial glia, is instead found in olfactory ensheathing cells, a result confirmed using lineage tracing with BLBP-cre mice. Nestin-cre-mediated lineage tracing with three different reporters reveals that only a subpopulation of nestin-expressing RGLPs activate the “CNS-specific” nestin regulatory elements, and produce spatially restricted neurons in the OE and vomeronasal organ. The dorsal-medial restriction of transgene-activating cells is also seen in the embryonic OE of Nestin-GFP transgenic mice, where GFP is found in a subpopulation of GFP+ Mash1+ neuronal progenitors, despite the fact that endogenous nestin expression is found in RGLPs throughout the OE. In vitro, embryonic OE progenitors produce three biologically distinct colony subtypes, that when generated from Nestin-cre/ZEG mice, produce GFP+ neurons, recapitulating their in vivo phenotype, and are enriched for the most neurogenic colony subtype. Neurogenesis in vitro is driven by the proliferation of nestin+ progenitors in response to FGF2. I thus provide evidence for a novel neurogenic precursor, the RGLP of the OE, that can be regulated by FGF2, and provide the first evidence for intrinsic differences in the origin and spatiotemporal potential of distinct progenitors during OE development.

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Patel, Nirmal Praful School of Medicine UNSW. "Olfactory progenitor cell transplantation into the mammalian inner ear". Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/26180.

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A practical consideration in the development of cellular therapy technology for the inner ear is the development of an in vitro model for assessing the optimal conditions for successful application of cells. The first part of this thesis describes the adaptation of the cochleovestibular structure harvested from P1 mouse pups for analysis of factors critical for the optimal implantation of stem cells in the inner ear. Results of these studies establish that the c17.2 neural stem cell line can be introduced into the cochleovestibular structure in vitro. Using this model, c17.2 cells demonstrated survival predominantly within the vestibule and basal spiral ganglion regions. Furthermore, the addition of the ototoxin, cisplatin and the neurotrophin, Brain Derived Neurotrophic Growth Factor (BDNF) enhanced the survival and migration/dispersion of c17.2 cells within the cochleovestibular explant. The second part of this thesis examines the hypothesis that olfactory neurosphere (ONS) and progenitor cells harvested from the olfactory epithelium represent a viable source of graft material for potential therapeutic applications in the inner ear. Olfactory epithelium represents a unique source of pluripotent cells that may serve as either homografts or autografts. The feasibility of ONSs to survive and integrate into a mammalian cochlea in vivo was assessed. The ONSs were isolated as a crude fraction from the olfactory epithelium of P1 to P3 day old swiss webster mouse pups, ubiquitously expressing the Green Fluorescent Protein (GFP) marker. The ONSs were microinjected into the cochleae of adult CD1 male mice. Four weeks following their implantation, ONS cells expressing the GFP marker and stained by Nestin were identified in all areas of the cochlea and vestibule, including the spiral ganglion. Robust survival and growth of the implanted ONS and ONS derived cells in the cochlea also included the development of ???tumor-like??? clusters, a phenomenon not observed in control animals implanted with c17.2 neural stem cells. Collectively, the results of this thesis illustrate the potential of olfactory neurosphere and progenitor cells to survive in the inner ear and expose a potential harmful effect of their transplantation.

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Malik, Astha. "Circadian Clocks in Neural Stem Cells and their Modulation of Adult Neurogenesis, Fate Commitment, and Cell Death". Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1434986257.

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Kalincik, Tomas Medical Sciences Faculty of Medicine UNSW. "Disturbances of autonomic functions in spinal cord injury: autonomic dysreflexia and thermoregulation". Publisher:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/43516.

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Disorders of the autonomic nervous system constitute serious complications of spinal cord injury (SCI) and their treatment is usually highly prioritised by spinal patients. Among these, autonomic dysreflexia and impaired thermoregulation are potentially life threatening conditions and require effective management. Olfactory ensheathing cells (OECs), progenitor cells and polymeric scaffolds have been tested in animal models of SCI and some of them have been considered for clinical trials. However, evaluation of the effect of such interventions on autonomic functions has received only rudimentary attention and would require a more thorough experimental assessment before the methods are utilised in human patients. This thesis tested two potential therapeutic strategies for autonomic dysreflexia and examined disorders of thermoregulatory functions in a rat model of spinal cord transection. Magnitude and duration of autonomic dysreflexia were evaluated with radio telemetry in spinalised animals treated with (i) implants of OECs and olfactory neurosphere-derived cells seeded in poly(lactic co glycolic) porous scaffolds or with (ii) transplants of OECs alone. (iii) Effects of SCI and of OECs on the morphology of sympathetic preganglionic neurons (SPNs; which are involved in pathogenesis of autonomic dysreflexia) stained for NADPH diaphorase were examined. (iv) Doppler ultrasonography and infrared thermography were used to assess responses of tail blood flow and surface temperature to cold. Transplants of OECs alone, but not in combination with olfactory neurosphere-derived cells and polymeric scaffolds, resulted in significantly shortened episodes of autonomic dysreflexia. This may be attributed to the alterations to the morphology of SPNs adjacent to the lesion: a transient increase in the morphometric features of the SPNs was evoked by spinal cord transection and this was further altered by transplantation of OECs. The thesis also showed that local responses of tail blood flow and temperature to cold were not abolished by complete SCI suggesting that temperature homeostasis could still be maintained in response to cold. It is hypothesised that OECs facilitate improved recovery from autonomic dysreflexia through alteration of the morphology of SPNs. Furthermore, it is suggested that the role of the tail in heat conservation can be regulated by mechanisms that are independent of the descendent neural control from supraspinal centres.

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Johnstone, Steven Andrew. "A comparative study of the biological and molecular properties of mesenchymal stem cells isolated from bone marrow and the olfactory system". Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6308/.

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Neurodegenerative conditions such as Multiple Sclerosis (MS) and spinal cord injury (SCI) affect hundreds of thousands of people each year worldwide, and numerous cell transplant-based therapeutic strategies are being investigated to aid in the repair and regeneration of the central nervous system. Of particular interest are mesenchymal stem cells (MSCs), due to their differentiation potential, their immunomodulatory effects, and their ability to stimulate various biological properties due to the substantial variety of growth factors, chemokines, and other signalling molecules secreted by these cells. MSCs taken from the bone marrow (BM-MSCs) have demonstrated significant reparative potential in animal models of both MS and SCI. The question I address throughout this thesis however, is whether MSCs from another niche; the olfactory mucosa (OM-MSCs), are a preferable or at least alternative candidate for such therapies, compared to BM-MSCs, and if they are, why are they? Previous studies have shown that OM-MSCs can be purified and grown from human olfactory mucosa and when incubated with rat glial/neuronal co-cultures are capable of increasing axonal myelination, an effect not elicited by BM-MSCs. This potentially has great therapeutic benefit for a range of neurodegenerative conditions, as a significant part of the regenerative process involves replacing the protective myelin membrane which ensheaths axons. A comparative study of the two types of MSCs shows a number of similarities, including the expression of the same panel of MSC markers, a 64% homology in miRNA expression, an ability to differentiate towards bone and fat, and a propensity for bone formation when cultured on osteogenic nanotographies. This thesis also outlines a number of differences between each phenotype which suggest that OM-MSCs could even be a preferred alternative, especially in neuroregenerative therapies. OM-MSCs were shown to express significantly more Nestin than BM-MSCs, and to proliferate at a significantly higher rate, two observations which may be related. This increased proliferation would have enormous benefit for their use, as BM-MSCs are mitotically quite slow, and any MSC-based therapies would require very large numbers of cells. Twenty six different miRNA were shown to be differentially expressed between BM-MSCs and OM-MSCs. Three of these; miR-140-5p, miR-146a-5p, and miR-335-5p were linked to three important biological functions; myelination, cell survival, and cell proliferation respectively. These three biological functions, importantly, are ones which were observed as being behavioural differences between OM-MSCs and BM-MSCs. OM-MSCs were also shown to secrete significantly more of the pro-myelinating chemokine, CXCL12, which was confirmed as being regulated by the microRNA, miR-140-5p. This offered a potential mechanism for the pro-myelinating effect of OM-MSCs, and also opens up new research potential for investigating therapeutic targets to regulate myelination. The data presented in this thesis shows many similarities between BM-MSCs and OM-MSCs, but it also highlights some profound differences which suggest that either they originate from a different lineage entirely, or that the cellular niche that they reside in does indeed affect the differentiation and behaviour of mesenchymal stem cells.

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Kolterud, Åsa. "The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems". Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-306.

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During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. A central issue in organogenesis is how a cell interprets such extrinsic signals and adopts a specific fate, and how the cell in response to this signal establishes reciprocal signaling. Transcription factors play a critical role in this process and my thesis focuses on the role of the LIM-homeodomain transcription factor, Lhx2, in the development of three different organ systems, the liver, the hematopoietic system and the olfactory system. The liver is formed from endoderm of the ventral foregut and mesenchyme of the septum transversum (st) and its development depends upon signaling interactions between these two tissues. As the liver becomes a distinct organ it is colonized by hematopoietic cells and serves as hematopoietic organ until birth. The fetal liver provides a microenvironment that supports the expansion of the entire hematopoietic system (HS) including the hematopoietic stem cells (HSCs). Liver development in Lhx2-/- embryos is disrupted leading to a lethal anemia due to insufficient support of hematopoiesis. To further investigate the role of Lhx2 in liver development I analyzed gene expression from the Lhx2 locus during liver development in wild-type and Lhx2-/- mice. Lhx2 is expressed in the liver associated st mesenchymal cells that become integrated in the liver and contribute to a subpopulation of hepatic stellate cells in adult liver. Lhx2 is not required for the formation of these mesenchymal cells, suggesting that the phenotype in Lhx2-/- livers is due to the presence of defective mesenchymal cells. The putative role of Lhx2 in the expansion of the HS was examined by introducing Lhx2 cDNA into embryonic stem cells differentiated in vitro. This approach allowed for the generation of immortalized multipotent hematopoietic progenitor cell (HPC) lines that share many characteristics with normal HSCs. The Lhx2-dependent generation of HSC-like cell lines suggests that Lhx2 plays a role in the maintenance and/or expansion of the HS. To isolate genes putatively linked to Lhx2 function, genes differentially expressed in the HPC lines were isolated using a cDNA subtraction approach. This allowed for the identification of a few genes putatively linked to Lhx2 function, as well as several stem cell-specific genes. The antagonist of Wnt signalling, Dickkopf-1 (Dkk-1), was identified in the former group of genes as it showed a similar expression pattern in the fetal liver, as that of Lhx2 and expression of Dkk-1 in fetal liver and in HPC lines appeared to be regulated by Lhx2. This suggests that Dkk-1 plays a role in liver development and/or HSC physiology during embryonic development. During development of the olfactory epithelium (OE) neuronal progenitors differentiate into mature olfactory sensory neurons (OSNs) that are individually specified into over a thousand different subpopulations, each expressing a unique odorant receptor (OR) gene. The expression of Lhx2 in olfactory neurons suggested a potential role for Lhx2 in the development of OSNs. To address this OE from Lhx2-/- and wild-type mice was compared. In the absence of functional Lhx2 neuronal differentiation was arrested prior to onset of OR expression. Lhx2 is thus required for the development of OSN progenitors into functional, individually specified OSNs. Thus, Lhx2 trigger a variety of cellular responses in different organ systems that play important roles in organ development in vivo and stem cell expansion in vitro.

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Książki na temat "Olfactory stem cells"

Calof, Anne. Systems Biology of Neural Stem Cells: Lessons from the Olfactory Epithelium. Morgan & Claypool Life Science Publishers, 2014.

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Calof, Anne L. Systems Biology of Neural Stem Cells: Lessons from the Olfactory Epithelium. Morgan & Claypool Life Science Publishers, 2014.

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Kempermann, MD, Gerd. Adult Neurogenesis 2. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199729692.001.0001.

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This resource is aimed at those interested in adult neurogenesis and stem cell biology of the adult brain, and covers the historical background and describes in detail adult neurogenesis in the hippocampus as well as the subventricular zone and olfactory bulb. It then discusses the regulatory mechanisms, and the subject of neurogenesis outside the "canonical" neurogenic regions of rodents and primates, as well as how adult neurogenesis in different species. It concludes with coverage of the provocative hypotheses that link failing adult neurogenesis with diseases such as temporal lobe epilepsy, major depression, schizophrenia, brain tumors, and dementias.

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Części książek na temat "Olfactory stem cells"

Richter, Miranda, Kathryn Westendorf i A. Jane Roskams. "Culturing Olfactory Ensheathing Cells from the Mouse Olfactory Epithelium". W Neural Stem Cells, 95–102. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-133-8_9.

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Barnett, Susan C., i A. Jane Roskams. "Olfactory Ensheathing Cells: Isolation and Culture from the Neonatal Olfactory Bulb". W Neural Stem Cells, 85–94. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-133-8_8.

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Malnic, Bettina, i Lucia Armelin-Correa. "Neurogenesis in the Olfactory Epithelium". W Perspectives of Stem Cells, 35–45. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3375-8_3.

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Suzuki, Yuko, i Masako Takeda. "Stem Cells of Olfactory Cells During Development". W Olfaction and Taste XI, 41–44. Tokyo: Springer Japan, 1994. http://dx.doi.org/10.1007/978-4-431-68355-1_16.

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Schwob, James E., Woochan Jang i Eric H. Holbrook. "Stem Cells of the Adult Olfactory Epithelium". W Neural Development and Stem Cells, 201–22. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3801-4_8.

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Schwob, James E., i Woochan Jang. "Stem Cells of the Adult Olfactory Epithelium". W Neural Development and Stem Cells, 219–33. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1385/1-59259-914-1:219.

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Féron, François, Chris Perry, Stéphane D. Girard i Alan Mackay-Sim. "Isolation of Adult Stem Cells from the Human Olfactory Mucosa". W Methods in Molecular Biology, 107–14. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-574-3_10.

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Enwere, Emeka, i Samuel Weiss. "Do Forebrain Neural Stem Cells Have a Role in Mammalian Olfactory Behavior?" W Stem Cells in the Nervous System: Functional and Clinical Implications, 67–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18883-1_5.

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Franceschini, Valeria, Simone Bettini, Riccardo Saccardi i Roberto P. Revoltella. "Stem Cell Transplantation Supports the Repair of Injured Olfactory Neuroepithelium After Permanent Lesion". W Trends in Stem Cell Biology and Technology, 283–97. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-905-5_16.

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Andrianov, Viacheslav V., Guzel G. Yafarova, Julia P. Tokalchik, Aleksandra S. Zamaro, Liya V. Bazan, Vladimir A. Kulchitsky i Khalil L. Gainutdinov. "Effects of Perineural Stem Cell Implantation on Motor Activity and Content of NO and Copper in the Olfactory System After Brain Ischemia". W Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics, 486–95. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71637-0_56.

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Streszczenia konferencji na temat "Olfactory stem cells"

Volkenstein, S., C. Sengstock, M. Rövekamp i S. Dazert. "Olfactory stem cells - a promising autologous approach to cell based therapies". W 100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN? Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1728954.

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Sengstock, C., S. Volkenstein, M. Rövekamp, S. Dazert, TA Schildhauer i M. Köller. "Autologous multipotent stem cells from human olfactory mucosa for treatment of sensory neural hearing loss". W Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686894.

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Sengstock, C., A. Neubaur, V. Stefan, B. Pintea, S. Dazert, R. Martínez-Olivera, T. Schildhauer i M. Köller. "Behaviour of isolated Olfactory Stem Cells within Cerebrospinal Fluid: a Prerequisite for Cell Therapy after Spinal Cord Injury". W Deutscher Kongress für Orthopädie und Unfallchirurgie. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1717436.

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Timme, Cindy R., Barbara H. Rath, Kevin Camphausen i Philip J. Tofilon. "Abstract 4171: Preferential radioresistance of glioblastoma stem-like tumor cells that migrate to the olfactory bulb". W Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4171.

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Marei, Hany, i Asmaa Althani. "Human Olfactory Bulb Neural Stem Cell Based Therapy for CNS Traumatic and Neurodegenerative Diseases". W Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2016. http://dx.doi.org/10.5339/qfarc.2016.hbpp1046.

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