Rozprawy doktorskie na temat „Olfactory epithelium”
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Schmachtenberg, Oliver. "Nitric oxide in the olfactory epithelium". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962820598.
Pełny tekst źródłaVedin, Viktoria. "Molecular and functional anatomy of the mouse olfactory epithelium". Doctoral thesis, Umeå : Umeå universitet, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-868.
Pełny tekst źródłaHsu, Pi-en. "Growth Factor Expression Associated With Regulation of Olfactory Neurogenesis". Thesis, Griffith University, 2005. http://hdl.handle.net/10072/367546.
Pełny tekst źródłaThesis (Masters)
Master of Philosophy (MPhil)
School of Biomolecular and Biomedical Sciences
Full Text
Blomster, Linda. "Role of fractalkine/CX3CL1 signalling in the regenerating olfactory epithelium". Thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-905.
Pełny tekst źródłaReed, C. J. "Studies of cytochrome P-450-dependent reactions in the olfactory epithelium". Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374871.
Pełny tekst źródłaWells, Karen Elizabeth. "Characterisation of the stem/precursor cells of the rat olfactory epithelium". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613198.
Pełny tekst źródłaChamberlain, Mark Peter. "The toxicity of methyl iodide : in vivo and in vitro mechanistic studies in the rat nasal cavity and cerebellum". Thesis, Liverpool John Moores University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244461.
Pełny tekst źródłaKilgour, Joanne Dawn. "Development and validation of an in vitro rat nasal epithelial model for predicting respiratory tract toxicity". Thesis, Liverpool John Moores University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361508.
Pełny tekst źródłaJang, Woochan. "The presence of fos-like immunoreactivity in neurons in the vomeronasal epithelium of mice /". free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9842591.
Pełny tekst źródłaMcCurdy, Richard D., i n/a. "Investigations of Olfactory Mucosa to Test the Neurodevelopmental Nature of Psychoses". Griffith University. School of Biomolecular and Biomedical Science, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20051121.133824.
Pełny tekst źródłaMcCurdy, Richard D. "Investigations of Olfactory Mucosa to Test the Neurodevelopmental Nature of Psychoses". Thesis, Griffith University, 2005. http://hdl.handle.net/10072/366460.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Rieling, Janine Ann. "Sensory receptor neuron turnover in the olfactory epithelium of the snail, Achatina fulica : an autoradiographical study". Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63382.
Pełny tekst źródłaGliem, Sebastian Verfasser], Detlev [Akademischer Betreuer] Schild, Ralf [Akademischer Betreuer] Heinrich i Jürgen [Akademischer Betreuer] [Wienands. "Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis / Sebastian Gliem. Gutachter: Detlev Schild ; Ralf Heinrich ; Jürgen Wienands. Betreuer: Detlev Schild". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1042304998/34.
Pełny tekst źródłaManzini, Ivan. "Diversity of transduction mechanisms in receptor neurons of the main olfactory epithelium in Xenopus laevis tadpoles". Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975110926.
Pełny tekst źródłaJoseph, Kyle Barnes. "Co-Localization of Basal and Proliferative Cells in the Murine Main Olfactory Epithelium and Vomeronasal Organ after Injury with Cyclophosphamide". ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/684.
Pełny tekst źródłaEdwards, Damian Andrew. "Nicotine as an odorant : a biochemical and electrophysiological study of receptors for nicotine in the olfactory epithelium of the rat". Thesis, University of Warwick, 1987. http://wrap.warwick.ac.uk/39023/.
Pełny tekst źródłaKolterud, Åsa. "The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems". Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-306.
Pełny tekst źródłaDe, las Heras Rachel, i n/a. "Neuronal Differentiation: A Study Into Differential Gene Expression". Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040225.161725.
Pełny tekst źródłaDe, las Heras Rachel. "Neuronal Differentiation: A Study Into Differential Gene Expression". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367735.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Girerd, Cédric. "Conception de robots à tubes concentriques et application à l'inspection des cellules olfactives". Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAD005/document.
Pełny tekst źródłaThis PhD thesis is part of the ANR NEMRO project, whose goal is to study the hypothetical correlation between olfactory deficiency and neurodegenerative diseases. For this purpose, an optical biopsy of the olfactory epithelium must be performed. However, this area is not accessible today with conventional tools. To go beyond this limitation, we propose to investigate the use a concentric tube robot (CTR). Its synthesis is performed from medical images. It takes into account the stability criteria, inter-subject variability, and is associated to a FTL (Follow-The-Leader) deployment. As the device is mounted on the subject, it has to be compact and lightweight. Thus, a specific deployment sequence simplifies the actuation unit, and an implementation is proposed using multimaterial additive manufacturing. Preliminary evaluations of the FTL deployment capabilities and the key components of the device allowed to validate the approach chosen for the NEMRO project, and its feasibility
Guo, Luzhi. "Ultrastructural characteristics of cultured embryonic mouse olfactory epithelial and bulb cells". Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798462/.
Pełny tekst źródłaMolinas, Adrien. "Mise en évidence de transporteurs de la résistance pléiotropique dans la muqueuse olfactive et leur implication dans la réponse aux odorants chez les rongeurs". Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00763536.
Pełny tekst źródłaNguyen, Duc Trung. "L'olfaction dans la polypose nasosinusienne avec et sans l'hamartome épithéliale respiratoire adématoïde de la fente olfactive". Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0233/document.
Pełny tekst źródłaBackground: The olfactory outcome after surgery of the olfactory clefts (OC) in patients with nasal polyposis (NP) is unknown. Objectifs: 1) to refine the description of the polyps' origin within the different subcompartments of the ethmoidal bone; 2) to investigate correlations, before and after surgery, between the sense of smell self-ratings and measures of olfactory function, and self-ratings of sense of smell and nasal obstruction; 3) to assess the olfactory outcome after surgery of ethmoidal labyrinths and OC for either Eosinophilic Polyps (EP) or Respiratory Epithelial Adenomatoid Hamartoma (REAH) in patients with nasal polyposis (NP). Samples: All patients with NP operated according to the nasalization procedure from September 2009 to November 2010 in our tertiary hospital (CHU de Nancy) were enrolled in these retrospective and prospective studies. Results: 1) Polyps were found in the middle meatus (98%), in the posterior olfactory fossa (75%), in the superior meatus (61%), on the middle turbinate proper (50%) and in the anterior olfactory fossa (40%); 2) Overall, self-ratings and measures of olfactory function correlated strongly preoperatively (r = - 0.66, p < 0.0001) and postoperatively (r = -0.67 at 6 weeks and -0.66 at 7 months, p < 0.0001). This relationship was better in patients with previous surgery. The correlation was weaker before (r = -0.35, p=0.01) than after surgery in hyposmic/anosmic patients (r = -0.74, p < 0.0001 at 6 weeks and r = -0.73, p = 0.0002 at 7 months) and wasn't found in normosmic patients. Self-ratings of nasal patency and smell were not correlated when the two complaints were dissociated; 3) There was a close relationship between the presence of REAH-OC and the duration of NP disease (p=.0009), asthma (p=.004) and previous surgery (p=.0006). Predictors of poor olfactory outcomes after surgery were low TI score before surgery (p = 0.028), history of previous middle turbinate resection (p = 0.0018), and recent middle turbinate resection (p = 0.04). Polyp histology and surgery of the OC were not predictors of poor olfactory outcomes. Conclusion: The evaluation of the sense of smell in patients with NP should be performed in combination of psychophysic tests and self-ratings of the olfactory function. The resection of REAH or EP of the OC in patients with NP does not worsen but instead can improve the postoperative olfaction
Gliem, Sebastian. "Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis". Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B5B9-D.
Pełny tekst źródłaSchmachtenberg, Oliver [Verfasser]. "Nitric oxide in the olfactory epithelium / von Oliver Schmachtenberg". 2001. http://d-nb.info/962820598/34.
Pełny tekst źródłaLee, Ting-Hein, i 李亭輝. "The expression of neuronal intermediate filament proteins in the developing mouse olfactory epithelium and olfactory bulb". Thesis, 1998. http://ndltd.ncl.edu.tw/handle/90410238719307512234.
Pełny tekst źródłaBrozzetti, Lorenzo. "Neurodegeneration associated-proteins in human olfactory epithelium: immunocytochemical and biomolecular study in healthy subjects and patients with synucleinopathies". Doctoral thesis, 2020. http://hdl.handle.net/11562/1017250.
Pełny tekst źródłaLiang, Kai-Hao, i 梁凱豪. "Characterization of the DNA elements that regulate the expression of CYP11A1 promoter in mouse olfactory epithelium". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/65057000411803513176.
Pełny tekst źródła國立臺灣大學
生理學研究所
101
Abstract Steroid hormones are mainly synthesized in adrenal cortex, gonads and placenta. Recent studies indicate that they are also produced in CNS. These so-called neurosteroids do affect physiological functions including neural survival, myelination, neurogenesis, etc. CYP11A1 encodes P450scc (cytochrome P450 side chain cleavage), which catalyzes the first and the rate-limiting step during steroidogenesis that changes cholesterol into pregnenolone. Thus, CYP11A1 plays an important part in steroidogenesis. CYP11A1 can be expressed in steroidogenic tissue, but at low level in brain. This makes CYP11A1 difficult to be detected and studied in brain. We tried to investigate the regulation and distribution of CYP11A1 by transgenic mice and proved that 4.4 kb length of CYP11A1 promoter is able to promote Cre recombinase expression in brain. Furthermore, we have curtailed the range which may contain the potential DNA elements in CYP11A1 promoter. In this thesis, we spliced the potential regulatory sequence into short segments and incubated them with mouse olfactory epithelium nuclear extracts for electrophoretic mobility shift assay (EMSA). Our results indicate that the binding sequences of olfactory epithelium nuclear molecules do exist in CYP11A1 promoter and may play important roles in its neural regulation. Since using transgenic mice for promoter research costs time and money, we are looking for some other in vitro transgenic system. Therefore, we constructed the retina electroporation system. We sent CYP11A1 promoter with Cre recombinase as the reporter gene in to retina tissue dissociated from mice cub. The results showed that although the retina electroporation system is able to transfect plasmids in to retina tissue, it still cannot help the weak promoter to trigger the reporter gene expression. In summary, this system is suitable for promoter studies except CYP11A1 promoter.
Jou, Yuan-Jia, i 周原加. "Effects of Neuregulin-1 Gene Mutation on the Structure and Neurogenesis of the Olfactory Epithelium in Adult Mice". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/67634559478064973745.
Pełny tekst źródła國立臺灣大學
解剖學暨生物細胞學研究所
100
Olfactory system is closely associatied with emotion and memory. Olfactory malfunction may lead to abnormal emotion, and this may play roles in mood-related disease, such as schizophrenia. Previous studies indicate that abnormal olfactory functions are common symptoms of schizophrenics, which include disturbed identification, discrimination, memory, and detection of odors. As shown by MRI scans, reduced bulb volumes were seen in schizophrenic patients. Neuregulin 1 (NRG1) is thought to be one of the susceptibility genes of schizophrenia. Neuregulin 1 (NRG1) and its receptors, ErbBs, may play important roles in the development of nervous system. Thus, the goal of this experiment was to examine the effects of the mutation of NRG1 gene on the olfaction and olfactory epithelium (OE) neurogenesis. Following behavioral observation 8 week-old wildtype (WT, NRG1+/+) and mutant (Mut, NRG1+/-) mice were intraperitoneally injected with bromodeoxyuridine (BrdU), 150 mg/kg, once daily for 3 consecutive days. On the 4th day (BrdU-D4), 10th day (BrdU-D10), 21st day (BrdU-D21) and 28th day (BrdU-D28) the mice were subjected to preparation for immunocytochemistry on their OE. Our results are as follows. 1. Behavior test results: NRG1 mutant mice showed decreased average body weight by about 9.2%. As revealed from the open field test, the distance and duration traveled by mutant mice were similar in the central and peripheral parts of the field respectively to that of WT. The olfactory habituation/dishabituation test revealed that, mutant mice were unable to discriminate different odors and litter odors. 2. Morphological results: (A) In the dorsal region of OE (i) The numbers of BrdU-positive cells were increased by 94.6% and 65.8% in the BrdU-D4 and BrdU-D10 mutant mice, compared to WT, whereas BrdU-D21 and BrdU-D28 mutant mice were similar to WT. (ii) Mutant mice contained 45.6% less number of the doublecortin (DCX) , a marker for neuroblasts, positive cells than that of WT. (iii) The levels of the olfactory marker protein (OMP) for mature olfactory receptor neurons (ORNs) were decreased by 28.9% and 18.6% in its expression area and OD in the Mutant mice. (iv) OE of mutant mice had 37.6% lower number of calretinin (CR) positive cells. (v) Mutant mice had 75.8% more number of cleaved caspase 3 positive cells. (B) In the septal region of OE (i) The numbers of BrdU-positive cells were increased by 62.1%, 54.5% and 54.6% in the BrdU-D4, BrdU-D10 and BrdU-D28 mutant mice, compared to WT, whereas BrdU-D21 mutant mice were similar to WT. (ii) Mutant mice contained 31.5% less number of the doublecortin (DCX) positive cells than that of WT. (iii) Mutant mice had 38.5% more number of cleaved caspase 3 positive cells, whereas OMP and CR expression were similar to WT. (C) Electron microscopy revealed that compared to that of WT, the number of nuclear membrane pores seemed incereased in the mutant basal cell and a single cilium arose from its basal part in the mutant ORN, instead of the multiple cilia arising from one single basal part in WT ORNs. Our results also confirmed the presence of NRG1 and ErbB 2 receptor in OE. These point out that the abnormal NRG1 protein may bind to the ErbB 2, leading to altered intracellular signaling of those specific cells. In the mutant mice, the decreased number and abnormal ultrastructure of olfactory receptor neurons may be related to their abnormal behavior and increased neurogenesis and apoptosis. NRG1 gene activity apparently is critically involved in the proliferation, differentiation and survival of neural cells, and thus may play important roles in the pathogenesis of schizophrenia.
Manzini, Ivan [Verfasser]. "Diversity of transduction mechanisms in receptor neurons of the main olfactory epithelium in Xenopus laevis tadpoles / submitted by Ivan Manzini". 2003. http://d-nb.info/975110926/34.
Pełny tekst źródłaAdler, Jenny [Verfasser]. "Charakterisierung des Plasmamembranproteoms aus dem olfaktorischen Epithel von Mus musculus = Characterization of the plasma membrane proteome of the olfactory epithelium from Mus musculus / vorgelegt von Jenny Adler". 2008. http://d-nb.info/993947727/34.
Pełny tekst źródłaKurtanska, Silvia. "Pharmakologische Charakterisierung der purinergen Rezeptoren der Stützellen der olfaktorischen Mukosa des larvalen Xenopus laevis". Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B1CE-1.
Pełny tekst źródłaŠmít, Daniel. "Analýza dynamických interakcí těl axonů a jejich biofyzikální modelování". Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-354435.
Pełny tekst źródłaCarter, Lindsay A. "Olfactory epithelial horizonal basal cells : an assessment of stem cell candidacy and behavioural regulation in vivo and in vitro". Thesis, 2002. http://hdl.handle.net/2429/12405.
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