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1

Fraser, Andrew K. Obstructive sleep apnoea and allied disorders. Glasgow: Scottish Forum for Public Health Medicine, 1997.

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Rees, Karen. Mechanisms of arousal responses from NREM sleep in patients with obstructive sleep apnoea. Salford: University ofSalford, 1995.

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Nicoll, Deborah J. Prospective evaluation of pulse transit time in the diagnosis and management of the obstructive sleep apnoea/hypopnoea syndrome. Oxford: Oxford Brookes University, 1999.

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4

Carr, Michele M. Pediatric obstructive sleep apnea. Alexandria, VA: American Academy Of Otolaryngology--Head and Neck Surgery Foundation, 2007.

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name, No. Snoring and obstructive sleep apnea. Wyd. 3. Philadelphia, PA: Lippincott Willians & Wilkins, 2003.

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6

Kim, Ki Beom, Reza Movahed, Raman K. Malhotra i Jeffrey J. Stanley, red. Management of Obstructive Sleep Apnea. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54146-0.

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de Vries, Nico, Madeline Ravesloot i J. Peter van Maanen, red. Positional Therapy in Obstructive Sleep Apnea. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-09626-1.

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Salman, Salam O., red. Modern Management of Obstructive Sleep Apnea. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11443-5.

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Kim, Su-Jung, i Ki Beom Kim, red. Orthodontics in Obstructive Sleep Apnea Patients. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-24413-2.

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10

Sacchetti, Lisandro M., i Priscilla Mangiardi. Obstructive sleep apnea: Causes, treatment and health implications. New York: Nova Science Publishers, 2012.

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11

Woodson, B. Tucker. Obstructive sleep apnea syndrome: Diagnosis and treatment. Alexandria, VA: American Academy of Otolaryngology--Head and Neck Surgery Foundation, 1996.

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Deenadayal, D. S., i Vyshanavi Bommakanti. Management of Snoring and Obstructive Sleep Apnea. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6620-9.

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13

Heiser, Clemens, i Nico de Vries, red. Upper Airway Stimulation in Obstructive Sleep Apnea. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-89504-4.

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14

Vicini, Claudio, Paul T. Hoff i Filippo Montevecchi, red. TransOral Robotic Surgery for Obstructive Sleep Apnea. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34040-1.

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15

Woodson, B. Tucker, Kenny Peter Pang i Brian W. Rotenberg. Advanced surgical techniques in snoring and obstructive sleep apnea. San Diego, CA: Plural Pub., 2013.

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16

Brooks, Dina. The effects of obstructive sleep apnea on blood pressure. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1997.

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17

Handelsman, Harry. Continuous positive airway pressure for the treatment of obstructive sleep apnea in adults. Rockville, Md: National Center for Health Services Research and Health Care Technology Assessment, U.S. Dept. of Health and Human Services, Public Health Service, 1987.

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18

Obstructive sleep apnea in adults: Relationship with cardiovascular and metabolic disorders. Basel: Karger, 2011.

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19

Seo, Jungmin. Development of Implantable Electronics as Novel Approaches to Obstructive Sleep Apnea. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8327-8.

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20

Craig, Sonya, i Sophie West. Obstructive sleep apnoea. Redaktorzy Patrick Davey i David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0136.

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Obstructive sleep apnoea (OSA) is caused by the repetitive closure of the pharynx during sleep, leading to sleep fragmentation and, often, daytime somnolence. Traditionally, it is defined as either the number of apnoeas (complete cessation of breathing for longer than 10 seconds) or hyponoeas (reduction in air flow by >50%) per hour in an overnight sleep study. However, it must be remembered that this definition is arbitrary, and OSA is better viewed as a spectrum with trivial snoring at one end and severe, almost continuous obstruction at the other. In addition to the sleep-study findings, if the patient is sleepy during the day, as defined by the Epworth Sleepiness Scale, then this condition is termed ‘obstructive sleep apnoea syndrome’. This distinction is important, as patients with this syndrome usually warrant treatment.
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21

Johnson, Jonas T., Jack L. Gluckman i Mark H. Sanders. Obstructive Sleep Apnoea. Informa Healthcare, 2001.

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22

Johnson, Jonas T., Jack L. Gluckman i Mark H. Sanders. Obstructive Sleep Apnoea. Taylor & Francis Group, 2003.

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23

Johnson, Jonas T., Jack Gluckman i Jack Sanders. Obstructive Sleep Apnoea. Taylor & Francis Group, 2001.

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24

Barbé, Ferran, i Jean-Louis Pépin, red. Obstructive Sleep Apnoea. European Respiratory Society, 2015. http://dx.doi.org/10.1183/2312508x.erm6715.

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Selim, Bernardo, i Kannan Ramar. Beyond positive airway pressure therapy: experimental and non-conventional treatments in sleep apnoea. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0259.

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With decreased adherence to positive airway pressure therapy to treat sleep apnoeas, non-conventional treatments based on new therapeutic targets are emerging. In central sleep apnoea syndrome associated with heart failure, phrenic nerve stimulation and non-conventional pharmacological treatments such as carbonic anhydrase inhibitors, gas therapies, and cardiac devices are novel alternative therapies. In obstructive sleep apnoea, a better understanding of predominant pathophysiological pathways is characterizing diverse clinical phenotypes. For patients with low arousal threshold, sedatives or hypnotics might be effective, whereas for those with unstable ventilatory control, carbonic anhydrase inhibitors or oxygen might improve obstructive sleep apnoea. For patients with upper airway muscle dysfunction, an increase in pharyngeal tone might be beneficial. This chapter describes ‘experimental’ therapies and novel technologies to treat these disorders.
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Walder, Dave, i Paul Reading. Narcolepsy: still sleepy on CPAP. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199657742.003.0011.

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Sleep disorders are an increasingly common reason for referral to the respiratory clinic, and our understanding of the different aetiologies is increasing. The commonest sleep disorder is sleep apnoea, but other sleep disorders can cause similar symptoms. Narcolepsy is a neurological disorder that affects the brain’s ability to regulate the normal sleep-wake cycle and often presents with similar symptoms to obstructive sleep apnoea, daytime hypersomnolence, and disturbed night-time sleeping but is largely underdiagnosed. This chapter discusses a patient who presented with symptoms of daytime somnolence and witnessed apnoeas and details the investigations required for a diagnosis of narcolepsy. It covers the more specialized sleep studies required for a clinical diagnosis and the treatment options available for patients with this condition.
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27

Epstein, Lawrence J. Sleep disorders. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198778240.003.0007.

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Over 70 described sleep disorders disrupt the sleep of an estimated 50–70 million Americans. The disorders present with a broad array of symptoms but result in the individual not getting the health, cognitive, and restorative benefits of a good night’s sleep. The disorders have been categorized into the following categories: insomnia, sleep-related breathing disorders, central disorders of hypersomnolence, circadian rhythm sleep–wake disorders, parasomnias, and sleep-related movement disorders. This chapter reviews each category and provides details on the symptoms, pathophysiology, and treatment of the most common disorder in each category, including insomnia, obstructive sleep apnoea, narcolepsy, restless legs syndrome, and REM sleep behaviour disorder. The presenting complaint is the key to diagnosis, directing subsequent evaluation.
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28

Edwards, Bradley A., i Garun S. Hamilton. Sleep and respiratory disorders. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198778240.003.0009.

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A number of sleep-related breathing and respiratory disorders impact our ability to achieve a good night’s sleep. Unfortunately, these disorders are becoming increasingly common—a phenomenon that has been linked to the rising obesity rates in society. In this chapter we aim to provide an overview of how some of the most common disorders (particularly obstructive sleep apnoea) contribute to poor sleep, review how these disorders/diseases impact both the individual and society, and discuss some of the key challenges and hurdles that we, as a society, will need to overcome if we are to maximize sleep quality in the community.
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Zaiwalla, Zenobia, i Roo Killick. Sleep disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688395.003.0035.

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As sleep medicine advances, there is increasing demand on services including neurophysiology to investigate sleep disorders. This chapter classifies the sleep disorders according to the main symptom presenting to the clinician, including excessive daytime sleepiness, insomnia, patients sleeping at the wrong times due to a circadian rhythm disorder, and movements or behaviours in sleep. The clinical presentation of common sleep disorders in each category are outlined, including obstructive sleep apnoea, narcolepsy, restless leg syndrome, periodic leg movements disorder, circadian rhythm disorders, and non-rapid eye movement and rapid eye movement parasomnias. The chapter discusses the overlap of symptoms in different sleep disorders, and the importance of selecting appropriate sleep studies, and recognizes the pitfalls, both clinical and in interpretation of sleep studies. The difficulties in diagnosing narcolepsy and differentiating from other causes of excessive daytime sleepiness, and when to investigate parasomnias is explained.
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30

Mosimann, Urs Peter, i Bradley F. Boeve. Sleep disorders. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0051.

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This book chapter reviews the most common sleep disorders in older adults and their treatment. It begins with a brief review of sleep physiology and then gives an outline on how to take a comprehensive sleep history. Sleep is commonly defined as a periodic temporary loss of consciousness with restorative effects. There are physiological sleep changes related to ageing, but sleep disorders are not part of normal ageing and are often associated with mental or physical disorders, pain and neurodegenerative disease. The most common sleep disorders include insomnia, obstructive sleep apnoea, restless legs syndrome, REM sleep behaviour disorder, excessive daytime somnolence and circadian rhythms disorders. An in depth clinical history, including if possible bed-partner’s information, is the key to diagnosis. Patients need to be informed about the physiological sleep changes and the principles of sleep hygiene. They can benefit from pharmacological and non-pharmacological treatment strategies.
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31

Miller, Michelle A. Sleep, inflammation, and disease. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198778240.003.0012.

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Sleep is a fundamental requirement for living individuals. Sleep disturbances and sleep disorders have extensive effects on the immune system, affecting one’s susceptibility to, and ability to fight off, infections—both bacterial and viral—and the subsequent development of different diseases. This is mediated by the increase in pro-inflammatory cytokines associated with sleep loss and disruption. A number of common conditions, such as obesity, cardiovascular disease, metabolic syndrome, obstructive sleep apnoea syndrome, rheumatoid arthritis, and systemic lupus erythematosus, all share pro-inflammatory mechanisms and the presence of sleep disturbances. Early identification of sleep disorders, and the associated adverse inflammatory and metabolic risk factors, in affected individuals would have a clear clinical benefit.
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32

Millar, Professor Ann B., Dr Richard Leach, Dr Rebecca Preston, Dr Richard Leach, Dr Richard Leach, Dr Wei Shen Lim, Dr Richard Leach i in. Respiratory diseases and respiratory failure. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199565979.003.0005.

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Chapter 5 covers respiratory diseases and respiratory failure, including clinical presentations of respiratory disease, assessment of diffuse lung disease, hypoxaemia, respiratory failure, and oxygen therapy, pneumonia, mycobacterial infection, asthma, chronic obstructive pulmonary disease (COPD), lung cancer, mediastinal lesions, pneumothorax, pleural disease, asbestos-related lung disease, diffuse parenchymal (interstitial) lung disease, sarcoidosis, pulmonary hypertension, acute respiratory distress syndrome, bronchiectasis and cystic fibrosis, bronchiolitis, eosinophilic lung disease, airways obstruction, aspiration syndromes, and near-drowning, pulmonary vasculitis, the immunocompromised host, sleep apnoea, and rare pulmonary diseases.
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33

Dodds, Chris, Chandra M. Kumar i Frédérique Servin. Cognitive dysfunction and sleep disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735571.003.0014.

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Cognitive dysfunction is largely a problem in the elderly, but it can occur at any age. The two major presentations, delirium and postoperative cognitive dysfunction (POCD), are compared. Risks for delirium are explored; key points from the patient’s history and possible ways to ameliorate the onset are then reviewed. The presentation of POCD is described, and the lack of our understanding of its causes is highlighted. Known triggers such as centrally active anticholinergic drugs or pain are identified. Current thinking in the inflammatory responses within microglia and astrocytes is summarized. Sleep in the elderly is contrasted with that in younger persons, and the main stages of sleep, SWS and REM, described. The impact and importance of the effects that surgery/anaesthesia has on sleep stages is reviewed. Obstructive sleep apnoea is described, including its effect on the safety of anaesthesia and recovery. Periodic limb movement disorders and early Parkinson disease are described.
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Harder, Louise, i Atul Malhotra. Pathophysiology and therapeutic strategy for sleep disturbance in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0225.

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Robust data have shown that sleep disruption and inadequate sleep duration in the general population impact neurocognitive function and produce cardiometabolic sequelae. Despite widespread recognition of the importance of sleep as an essential homeostatic function, there are relatively few data regarding the importance of sleep in critically-ill patients. Obstructive sleep apnoea is a common respiratory condition that is prevalent in the ICU and can be particularly problematic pre-intubation, post-extubation, and in the peri-operative setting. Considerable discussion regarding the impact of sleep versus sedation has occurred, with some insights emerging from improvements in our understanding of basic neurobiology. Sleep disturbance may also have an impact in critically-ill mechanically-ventilated patients by contributing to the development of delirium, which is associated with poor outcomes. However, further data are required to determine the ideal strategy to optimize sleep in the ICU and whether such strategies will in turn improve hard outcomes of critically-ill patients.
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Herbert, Lara, i Bruce McCormick. Respiratory disease. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198719410.003.0005.

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This chapter describes the anaesthetic management of the patient with respiratory disease. It describes the assessment of respiratory function and preoperative respiratory investigations, and ventilatory strategies to reduce pulmonary complications. Common respiratory conditions covered include respiratory tract infection, smoking, asthma, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, obstructive sleep apnoea, sarcoidosis, restrictive pulmonary disease, and the patient with a transplanted lung. For each topic, preoperative investigation and optimization, treatment, and anaesthetic management are described. Recommendations for the patient who may require post-operative respiratory support (e.g. non-invasive ventilation) are provided.
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Herbert, Lara, i Bruce McCormick. Respiratory disease. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198719410.003.0005_update_001.

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This chapter describes the anaesthetic management of the patient with respiratory disease. It describes the assessment of respiratory function and preoperative respiratory investigations, and ventilatory strategies to reduce pulmonary complications. Common respiratory conditions covered include respiratory tract infection, smoking, asthma, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, obstructive sleep apnoea, sarcoidosis, restrictive pulmonary disease, and the patient with a transplanted lung. For each topic, preoperative investigation and optimization, treatment, and anaesthetic management are described. Recommendations for the patient who may require post-operative respiratory support (e.g. non-invasive ventilation) are provided.
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Cohen, Edmond. Upper airway obstruction in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0079.

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Upper airway obstruction (UAO) from any cause should be considered a life-threatening emergency. In a conscious patient, UAO may present as respiratory distress, stridor, dyspnoea, altered voice, cyanosis, cough, decreased or absent breath sounds, wheezing, the hand-to-the-throat choking sign in the case of a foreign body, facial swelling, and distended neck veins. The cause of UAO should be identified and airway management devices must be immediately available prior to any airway manipulation CT scan, flexible bronchoscopy, and pulmonary function tests should be performed to evaluate the cause and the extent of the obstruction. Obstructive sleep apnoea (OSA) patients are at increased risk of developing UAO. Endotracheal intubation, insertion of a supraglottic device, laser therapy, and endotracheal stents maybe life-saving
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38

1960-, Kushida Clete Anthony, red. Obstructive sleep apnea. New York, NY: Informa Healthcare USA, 2007.

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Kushida, Clete A. Obstructive Sleep Apnea. Taylor & Francis Group, 2007.

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Squire, Peter. Obstructive Sleep Apnea. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0012.

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Adenotonsillectomy has become first-line treatment for obstructive sleep apnea (OSA) and it is increasingly performed as a day-case procedure. A diagnosis of OSA increases the risk for postoperative respiratory morbidity from 1% to approximately 20% and unfortunately, the clinical history may be unreliable at distinguishing which children are at greatest risk. The gold standard investigation is overnight polysomnography (PSG), but this is a scarce resource considering the number of procedures performed. Fortunately, overnight home pulse oximetry also provides a useful stratification of severity and may predict postoperative problems. Children with OSA have a respiratory drive and airway tone that may be exquisitely sensitive to anesthetic and analgesic agents. Accordingly, the anesthesiologist needs to identify which patients are most at risk, and therefore which patients can be managed as “day cases,” what is an appropriate anesthetic regimen, and how best to monitor these patients postoperatively.
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Rogula, Tomasz G., Adriana Martin i Ivan Alberto Zepeda Mejia. Obstructive Sleep Apnea. Redaktorzy Tomasz Rogula, Philip Schauer i Tammy Fouse. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190608347.003.0018.

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Obstructive sleep apnea (OSA) is highly prevalent in morbidly obese patients, although it is surprisingly underdiagnosed and undertreated. OSA can increase the risk of serious and life-threating complications in the perioperative period of bariatric surgery. Nevertheless, this potential risk can be minimized with adequate preoperative screening and perioperative management. The perioperative management of patients with OSA will affect the preparation for surgery, airway management, anesthetic selection, and monitoring. This chapter discusses and presents the best evidences available for the management of patients with OSA in order to decrease both the prevalence of undiagnosed patients and the morbidity associated with bariatric surgery.
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42

Ryan, Laura, i Paul Hopkins. Obstructive Sleep Apnea. Redaktorzy Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel i Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0011.

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Adenotonsillectomy is one of the most commonly performed surgeries in children and is the mainstay treatment for obstructive sleep apnea (OSA). Children with OSA have a higher risk of perioperative respiratory morbidity. Diagnosis of OSA is made by overnight polysomnography, but this resource is rare and expensive so children at risk for OSA must be identified based on parental history. Patients with risk factors for postoperative respiratory complications may need to be monitored in the hospital overnight. Anesthetic challenges associate with adenotonsillectomy include perioperative analgesia, prevention and treatment of postoperative nausea and vomiting, risk of airway fire, and management of airway obstruction.
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Kushida, Clete A. Obstructive Sleep Apnea. CRC Press, 2007. http://dx.doi.org/10.1201/9781420061819.

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Obstructive Sleep Apnea. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03936-079-6.

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Kushida, Clete A. Obstructive Sleep Apnea. Taylor & Francis Group, 2007.

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1960-, Kushida Clete Anthony, red. Obstructive sleep apnea. New York, NY: Informa Healthcare USA, 2007.

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47

Jolly, Elaine, Andrew Fry i Afzal Chaudhry, red. Respiratory medicine. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199230457.003.0018.

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Chapter 18 covers the basic science and clinical topics relating to respiratory medicine which trainees are required to learn as part of their basic training and demonstrate in the MRCP. The chapter starts with an introduction to the respiratory system, before covering respiratory defence and physiology, respiratory investigations, respiratory failure, pneumonia, tuberculosis, cystic fibrosis, bronchiectasis, pleural effusion, chronic obstructive pulmonary Disease, adult respiratory distress syndrome, asthma , fungal lung diseases, pulmonary embolism , lung cancer, pulmonary fibrosis, extrinsic allergic alveolitis, occupational lung diseases, sarcoidosis, Cor pulmonale and pulmonary hypertension, pneumothorax, cough and haemoptysis, pulmonary eosinophilia, and obstructive sleep apnoea.
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48

Devlin, Hugh, i Rebecca Craven. The respiratory system. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759782.003.0008.

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The respiratory system in relation to dentistry is the topic of this chapter. Gaseous exchange in the lungs is mainly controlled by central chemoreceptors sensing a change in the pH of the cerebrospinal fluid. These receptors then activate a respiratory response which returns the blood and cerebrospinal fluid pH to normal. Localized airway obstruction, obstructive sleep apnoea, and lung disease can cause hypoxaemia (a low arterial oxygen oncentration) and hypercapnia (a raised carbon dioxide concentration in the blood). We emphasize the specific dental issues in patients with asthma, i.e. the dry mouth when taking β‎‎2-adrenergic agonists and the management of an acute asthmatic attack. Specific points of relevance to the dentist are summarized in sections throughout the chapter.
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Nasimudeen, Abdul. Screening for respiratory disease. Redaktorzy Patrick Davey i David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0352.

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Routine screening for respiratory diseases is currently not available to the general healthy population, with the exception of screening for cystic fibrosis. This chapter discusses the screening strategies in place for cystic fibrosis, TB, and other conditions, such as COPD, lung cancer, alpha-1 antitrypsin deficiency, pulmonary hypertension, pulmonary arteriovenous malformation, and obstructive sleep apnoea, for which screening can be applied. While screening has the potential to improve quality of life through early diagnosis and management, it is not an easy process and cannot offer a guarantee of protection.
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50

Obstructive Sleep Apnea (Fast Facts). Health Press (UK), 2004.

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