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Bell, Lana Michelle. "The medical complications of childhood obesity". University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0139.
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[Truncated abstract] Introduction: Childhood obesity is currently a serious worldwide public health issue associated with many medical and psychosocial complications. The increasing disease burden with the potential for the development of medical co-morbidities has implications for future health care provision. This thesis adds to the understanding of the medical complications of overweight and obesity in childhood. Design and Aims: Two different, but related, research studies are reported. The first study is a cross-sectional study, designed to quantify the medical complications of childhood obesity in primary school-aged children in Western Australia. This study aims to identify the medical complications of primary school children with overweight/obesity. The study also aims to compare the medical complications of obesity in a community sample who have never sought treatment with a clinical sample who are actively seeking treatment for overweight/obesity. Finally, this study also aims to examine the relationship between the medical complications of childhood obesity and a continuum of children's Body Mass Index z-scores, including those in the normal range. The second study is an exercise intervention study to investigate the effect of exercise on one specific medical complication of obesity, namely insulin resistance. This study aims to determine if a structured eight-week exercise program significantly changes insulin resistance in obese children, and to determine if this decrease in insulin resistance is associated with changes in body composition and inflammatory markers. ... Conclusion: The prevalence of the medical complications of overweight and obesity in primary school children indicates that all children should have body mass index regularly checked from a young age. Children who are overweight/obese should be screened for the presence of co-morbidities despite a young age. Parents and health professionals needs to be educated that childhood obesity is associated with medical co-morbidities and is not simply a social or cosmetic concern. The continuous nature of the BMI z-score/co-morbidities relationship suggests that public health and health education strategies should include adopting a populationbased approach to weight management. This continuous relationship means that even in the normal BMI spectrum, the risk of developing co-morbidities rises with increasing BMI. Such an approach would encourage maintenance of normal weight for all children, rather than targeting overweight/obese children only. Increased activity and decreased sedentary behaviours should be recommended for all children in line with the population-based public health approach suggested above. However, exercise has a specific role in weight management strategies for overweight/obese children, and in management strategies for adiposityrelated co-morbidities. Significant metabolic benefits of exercise occur in the absence of changes in body shape and weight. After an exercise program, simple blood investigations (such as lipid profiles, fasting insulin and OGTTs) are likely to miss important metabolic improvements and anthropometry (BMI calculation, waist circumference) may be more indicative of potential metabolic improvement and decreased co-morbidity risk.
2
Okwuosa, Veronica A. "Obesity among Latino children". Thesis, California State University, Long Beach, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1522591.
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Obesity is described as a chronic disease affecting adults, children, and adolescents. It has become a significant burden for the healthcare system and is considered one of the top health problems contributing to severe complications from childhood through adulthood. Obesity represents one of the most worrisome health problems in the United States, because it directly affects the health of individuals.
The research objective was to educate parents and grandparents of Latino children under age 17 regarding the importance of healthy food choices and physical activity. The aim was to empower parents and grandparents to practice health promotion and disease prevention. A descriptive design with pretest and posttest was utilized to indicate the knowledge gained by participants after the instructional phase. The result of the data analysis indicated an increase for the majority of participants regarding their level of understanding about healthy eating and the importance of physical activity.
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Rowlinson, Madaleine. "Obesity stigma in young children". Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/1740/.
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The prevalence of obesity has increased over recent years but obesity stigma remains widespread. The main aim of this study was to examine whether the hypothesised rejection of fatness by young children is specific to overweight or common to other visible difference. Whether the body size of the character’s peer group moderates or accentuates the rejection was also examined. One hundred and fifty, four to six year old school children (79 girls, 71 boys, mean age of 5 years and 7 months), were individually interviewed. The main character was presented in a story as either overweight, in a wheelchair or average weight. The character’s peer group was also varied in weight. Two methods were used to evaluate the character’s perceived attributes. The main and comparison characters were rated on five point scales. Then participants chose which character was most likely to possess the attribute. Participants also made a friendship choice. Forced choice attribute questions showed a preference for the average weight over the overweight character for happiness with her looks, number of friends, likelihood of receiving party invites, being good at school work and likelihood of winning a race. The character in a wheelchair was also rejected but on fewer attributes. Ratings showed significant differences on similar attributes but the mean scores were neutral or positive, rather than negative. On the friendship choice between the overweight and average weight characters children rejected the overweight character. The weight of the character’s peer group was also found to affect perceptions of the main character. Young children perceive and evaluate obesity differently to other visible difference but not overwhelmingly negatively. Peer relationships appear to be the attribute most affected. Social context also appears to be important at this age. The way in which children are asked to make judgements appears to affect the degree of negativity.
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Yeung, Chun-yu. "Adipocyte- and epidermal-fatty acid-binding proteins in relation to obesity and its medical complications". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B44204565.
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Jones, S. M. "The ocular complications in children with epidermolysis bullosa". Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1338582/.
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Epidermolysis bullosa (EB) describes a group of inherited bullous disorders affecting the basement membrane zone of skin and mucous membranes. It is characterised by fragility and blistering of the skin and mucosa following friction or mechanical trauma. Ocular features are thought to result from a lack of adherence and disruption of the corneal and/or conjunctival epithelium. This thesis aimed to prospectively evaluate the ocular complications occurring in children with EB via comprehensive ocular examination including assessment of the anterior segment, posterior segment and ocular movements. Findings demonstrated the majority of EB patients exhibit signs of meibomian gland dysfunction (MGD) and decreased tear break up time (TBUT), abnormal tear films on Tearscope® evaluation and ocular surface anomalies. Two further cohorts were studied; a) Age-matched control patients with no anterior segment pathology to provide normative data on MGD and TBUT and b) Children diagnosed with MGD who did not suffer from EB to compare the ocular surface phenotype in these, with that in children with EB and MGD. Having identified MGD and an abnormal ocular surface in children with EB, and shown effective management of MGD in otherwise healthy children, translational research was performed to evaluate the effect of potential therapeutic options at a cellular level. Skills in tissue culture and flow cytometry were developed to work with two untransfected conjunctival cell lines (Immortalized Cell Line (IOBA-NHC) and the Wong-Kilbourne derivative of Chang cells) as an in vitro method to investigate the effect of the current therapeutic agents for MGD on the conjunctival epithelial inflammatory response. In conclusion this thesis furthers our understanding of the ocular phenotype in EB subtypes, the aetiology of ocular features and the appropriate management. Findings may allow future therapeutic developments with greater specificity for children with EB.
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Singh, Rashmi Roshan. "Enteral feeding methods and surgical complications in children". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057352/.
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Background: In the unwell child who is unable to feed orally, various methods for enteral feeding having been advocated. The ideal method for a particular child has to be tailored according to his/her anatomy, physiology and requirements. The impact of complex medical background on outcomes and complications following a surgical procedure in children remains largely unrecognized. Aims: 1. To determine whether percutaneous endoscopic gastrostomy (PEG) is superior to radiologically inserted gastrostomy (RIG) 2. To determine outcomes following surgical jejunostomy (SJ) or radiologically inserted gastro-jejunal (RGJ) tube 3. To study complications after surgery and determine its effect Methods: A double-blinded randomised controlled trial was conducted in children needing gastric feeding, who received either a PEG or RIG. They were followed up for up to 3 years to record any complication. Retrospective reviews of buried bumpers (a specific complication of gastrostomy), and the nutritional outcomes following jejunostomy placement (SJ or RGJ) was carried out. Available scoring systems for post-operative complications were reviewed and initial development of a new paediatric complexity scoring system was performed. Results: In the trial 198 children were randomised (100 PEG and 98 RIG). They were followed up to a median of 1 year (6 weeks to 3 years). There was no difference between total number of complications or the rate of complications, following PEG or RIG. Both SJ and RGJ are able to maintain and improve growth in a carefully selected group of children. There is a need for validation of a developed paediatric complexity scoring system. Conclusions: PEG and RIG have equivalent rates of complications. SJ and RGJ cannot be compared as they are used for patients at different stages in a spectrum of malnutrition. Impact of the complexity of paediatric patients on their post-operative complications needs thorough consideration to improve outcomes.
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Liu, Tsz-chiu, i 廖子超. "Lipocalin-2 is a pro-inflammatory adipokine causally involved in obesity-associated endothelial dysfunction". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45589434.
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Stewart, Victoria Stephanie. "Weight-loss interventions performed to reduce the risk of obesity-related complications". ScholarWorks, 2014. https://scholarworks.waldenu.edu/dissertations/109.
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The management of obesity before a woman conceives is one of the most effective efforts a woman can take in decreasing her risk of obesity-related complications during pregnancy. Evidence supports the idea that maternal obesity influences maternal and fetal outcomes, leading to maternal and fetal morbidities. Physicians acknowledge the importance of screening women for obesity, but many do not refer patients for weight-loss therapy. In this study, the health belief model was used to explore the associations between participants' obesity risk of complications during pregnancy, the number of weight-loss interventions they attempted to implement prior to pregnancy, and how they viewed the success of their interventions. Participants were a random sample of 95 obese pregnant women older than 19 years participating in the supplemental WIC program in an urban community in Newark, New Jersey. A quantitative nonexperimental correlational study using descriptive and inferential statistics was used to analyze the data. The results of this study indicated that obese pregnant women did not perceive the risks associated with obesity as a problem, nor was there an association among the types of weight-loss methods attempted, the overall success of their weight-loss interventions, and ethnicity. Women who tried exercise and dietary restrictions or exercise only were more likely to experience success than those who tried other methods or combinations of methods (p = 0.012). The data provided can lead to better informed strategies by health care professionals to develop standards in healthcare, particularly obstetrics and gynecology offices and clinics, to help obese women be more compliant with treatment recommendations for reducing the risks of obesity-related health problems.
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Bailey, Swneke. "Genetic insights into obesity and its associated metabolic complications: a multiethnic perspective". Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104623.
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Obesity has become one of the biggest threats to global health, as it frequently co-occurs with a constellation of type 2 diabetes (T2D) and cardiovascular disease (CVD) risk factors and is associated with increased mortality. Genetic factors account for a substantial portion of the phenotypic variance in obesity and each of the correlated vascular disease risk factors. In this thesis, I describe the identification of several common genetic variants that predispose carriers to the complications associated with obesity. First, I report the identification of common variation within the gene of a protein secreted by visceral adipose tissue, visfatin, and demonstrate the influence of these variants on the inter-individual variation in fasting insulin levels. Second, I describe the identification of an interaction between the use of thiazolidinediones (TZDs), a class of anti-hyperglycemic medication, and variation in the nuclear factor of activated T-cells cytoplasmic component 2 (NFATC2) gene that results in edema and potentially congestive heart failure (CHF). Next, using a South Asian population sample for gene discovery, I identify a novel association between variation in the dipeptidyl peptidase 4 (DPP4) gene, a target of incretin-based anti-hyperglycemic medication, and apolipoprotein B (apoB) levels, a CVD risk factor and marker of the dyslipidemia associated with obesity. In addition, using observed differences between the Europeans and South Asians I was able to identify heterogeneity in the association between DPP4 and apoB caused by adiposity. Finally, I report an association between variation in the sterol regulatory element binding protein 1 (SREBF1) gene and body mass index (BMI) and demonstrate its potential contribution to observed differences in BMI among different ethnicities around the world. I also present data that strongly suggest that these differences may have been due to recent positive selection at this locus in human populations. The findings in this thesis illustrate the importance of common genetic variants in the pathogenesis of obesity, as well as its associated complications and highlight the regulation of glucose by adipose tissue as an important underlying feature.L'obésité est devenue une des plus grandes menaces dans la santé publique, étant donné qu'elle est fréquemment co-reliée avec des facteurs de risque du diabète de type 2 (T2D) et de la maladie cardiovasculaire (CVD), et est donc associée à une mortalité accrue. Les facteurs génétiques représentent une partie substantielle de la variation phénotypique de l'obésité, ainsi que des facteurs de risque des maladies vasculaires qui y sont associés. Dans cette thèse, je décris l'identification de plusieurs variants génétiques communs qui prédisposent les porteurs aux complications associées à l'obésité. D'abord, je décris l'identification d'une variation commune dans le gène d'une protéine sécrétée par le tissu adipeux viscéral, visfatin, et démontre l'influence de ces variants sur la variation interindividuelle d'une insulinémie à jeun. Deuxièmement, je décris l'identification d'une interaction entre l'utilisation des thiazolidinediones une classe de médicaments anti-hyperglycémiques, et une variation génétique dans le gène nuclear factor of activated T-cells cytoplasmic component 2 (NFATC2) qui aboutit à l'œdème et potentiellement à l'insuffisance cardiaque congestive. Ensuite, en utilisant un échantillon de la population asiatique du Sud dans la découverte de gènes, j'identifie une nouvelle association entre la variation du gène dipeptidyl peptidase 4 (DPP4), une cible de la médication anti-hyperglycémique basée sur l'incretin, et les niveaux de l'apolipoprotéine B (apoB), un facteur de risque du CVD et un marqueur de la dyslipidémie associée à l'obésité. De plus, en utilisant des différences observées entre les Européens et les Asiatiques du Sud, j'ai pu identifier l'hétérogénéité dans l'association entre DPP4 et apoB causé par l'adiposité. Finalement, je décris une association entre la variation du gène sterol regulatory element binding protein 1 (SREBF1) et l'indice de masse corporelle (BMI) et démontre sa contribution potentielle aux différences de BMI observées parmi différentes ethnicités dans le monde entier. Je présente aussi des données qui suggèrent fortement que ces différences peuvent être dues à une récente sélection positive à ce locus dans des populations humaines. Les découvertes de cette thèse illustrent l'importance des variants génétiques communs dans la pathogenèse de l'obésité, ainsi que les complications qui s'y rattachent et mettent en évidence la régulation de glucose par le tissu adipeux comme étant une caractéristique sous-jacente importante.
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Kaw, Roop, Priyanka Bhateja, y. Mar Hugo Paz, Adrian V. Hernández, Anuradha Ramaswamy, Loutfi S. Aboussouan i Abhishek Deshpande. "Postoperative Complications in Patients with Unrecognized Obesity Hypoventilation Syndrome Undergoing Elective Non-cardiac Surgery". American College of Chest Physicians, 2015. http://hdl.handle.net/10757/558500.
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BACKGROUND: Among patients with obstructive sleep apnea (OSA) a higher number of medical morbidities are known to be associated with those that have obesity hypoventilation syndrome (OHS) compared to OSA alone. OHS can therefore pose a higher risk of postoperative complications after elective non-cardiac surgery (NCS) and is often unrecognized at the time of surgery. The objective of this study was to retrospectively identify patients with OHS and compare their postoperative outcomes with those who have OSA alone. METHODS: Patients meeting criteria for OHS were identified within a large cohort of patients with OSA who underwent elective NCS at a major tertiary care center. We identified postoperative outcomes associated with OSA and OHS as well as the clinical determinants of OHS (BMI, AHI). Multivariable logistic or linear regression models were used for dichotomous or continuous outcomes, respectively. RESULTS: Patients with hypercapnia from definite or possible OHS, and overlap syndrome are more likely to develop postoperative respiratory failure [OR: 10.9 (95% CI 3.7-32.3), p<0.0001], postoperative heart failure (p<0.0001), prolonged intubation [OR: 5.4 (95% CI 1.9-15.7), p=0.002), postoperative ICU transfer (OR: 3.8 (95% CI 1.7-8.6), p=0.002]; longer ICU (beta coefficient: 0.86; SE: 0.32, p=0.009) and hospital length of stay (beta coefficient: 2.94; SE: 0.87, p=0.0008) when compared to patients with OSA. Among the clinical determinants of OHS, neither BMI nor AHI showed associations with any postoperative outcomes in univariable or multivariable regression. CONCLUSIONS: Better emphasis is needed on preoperative recognition of hypercapnia among patients with OSA or overlap syndrome undergoing elective NCSRevisión por pares
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Tin, Sze-pui Pamela, i 田詩蓓. "Lifestyle, self-esteem and obesity among children". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196449.
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Background: Childhood obesity remains a major public health concern. While preventing childhood obesity is important, the effectiveness of existing prevention strategies is indefinite. Important obesity contributors are speculated to be overlooked while the role of well-studied obesity-related factors has been questioned.
Objectives:
1) Although the association between lifestyle and obesity is seemingly well-established, how an overlooked dietary factor, breakfast location, associates with obesity was investigated
2) At a time where inconsistencies in findings for the frequently studied association between TV viewing and obesity still exist, this thesis tested for the existence of the said association in the understudied Chinese population
3) The effect of mental health on childhood obesity is understudied. Using self-esteem as a mental health indicator, the effect of self-esteem on childhood obesity was investigated
To understand the role of lifestyle factors in the association between self-esteem and obesity, how 4) breakfast habit and 5) TV viewing habit associates with self-esteem was explored
Methods: A cohort of 83405 primary 4 (P4) Department of Health Student Health Service participants (49.7% male, mean age 9.9 years) in 1998-2000 were successfully tracked for 2 years into primary 6 (P6). A self-administered health questionnaire collected information on the breakfast and TV habits of participants alongside other lifestyle characteristics. Self-esteem was assessed using the four Culture Free Self-Esteem Inventories for Children (SEI) subscales. Body mass index (BMI) was derived using objectively measured weight and height. Weight status was classified in accordance to International Obesity Task Force standards. Logistic, multinomial logistic and linear regression were used to yield adjusted odds ratios (AOR) and β-coefficients for becoming overweight/obese in P6 (among P4 normal weight children), breakfast skipping/location, TV viewing habit and SEI subscale scores. Breakfast skipping behaviour was tested as a mediator in the association between self-esteem and obesity using standard mediation procedures. Breakfast and TV viewing habits were tested as effect modifiers in the same association by inclusion of interaction terms in models.
Results: Among normal weight P4 children, those who skipped breakfast (AOR: 1.24; 95% CI: 1.02 to 1.51) or ate away from home (1.39; 1.20 to 1.60) were more likely to become overweight/obese in P6. Poor self-esteem was also associated with higher AORs for becoming overweight/obese, particularly among girls.
While TV viewing in P4 did not predict overweight/obesity in P6, those who increased TV watching hours (≤2h/day to 2h/day) during the two follow-up years were 32% more likely to become overweight/obese in P6 than their counterparts who maintained watching ≤2h/day.
Breakfast habit and self-esteem was bi-directionally associated. Although a curvilinear inverted J-shaped relation between P4 TV viewing and P6 self-esteem was observed, self-esteem did not predict TV viewing habit.
While neither breakfast nor TV viewing habit significantly interacted with self-esteem to predict obesity, breakfast skipping was found to be a potential partial mediator in the association between self-esteem and obesity.
Conclusion: Breakfast location, self-esteem and TV viewing patterns over time are important to consider in relation to childhood obesity. Additionally, the association between self-esteem and obesity could be mediated by lifestyle factors.published_or_final_version
Community Medicine
Doctoral
Doctor of Philosophy
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Stenberg, Erik. "Preventing complications in bariatric surgery". Doctoral thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50649.
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Obesity is a major public health problem. Bariatric surgery is currently the only available treatment that offers sufficient weight-loss and metabolic benefits over time. Although bariatric surgery is considered safe now, serious complications still occur. The aim of this thesis was to identify factors associated with an increased risk for postoperative complication after laparoscopic gastric bypass surgery. Study I included patients operated with laparoscopic gastric bypass surgery in Sweden from May 2007 until September 2012. The risk for serious complication was low (3.4%). Suffering an intraoperative adverse event or conversion of the operation to open surgery were the strongest risk factors for postoperative complication. The annual operative volume and experience of the procedure at the institution were also important risk factors. Patient-specific risk factors appeared to be less important although age was associated with an increased risk. In Study II, a raised glycated haemoglobin A1c (HbA1c) was evaluated as a risk factor for serious postoperative complications in non-diabetics. A higher incidence of serious postoperative complications was seen with elevated HbA1c values, even at levels classified as ‘‘pre-diabetic’’. Study III was a multicentre, randomised clinical trial (RCT). 2507 patients planned for laparoscopic gastric bypass surgery were randomised to either mesenteric defects closure or non-closure. Closure of the mesenteric defects reduced the rate of reoperation for small bowel obstruction from 10.2% to 5.5% at 3 years after surgery. A small increase in the rate of serious postoperative complication within the first 30 days was seen with mesenteric defects closure. This relatively small increase in risk was however outweighed by the marked reduction of later reoperations for small bowel obstruction. Study IV was a comparison between study III and an observational study on the same population under the same period of time. Although the observational study reached the same conlusion as the RCT, the efficacy of mesenteric defects closure was less pronounced. Observational studies may thus be an alternative to RCTs under situations when RCTs are not feasible. The efficacy may however be underestimated.
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He, Qing, i 何淸. "Childhood obesity: definition, risk factors and consequences". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31240252.
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He, Qing. "Childhood obesity : definition, risk factors and consequences /". Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21904145.
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Yeung, Chun-yu, i 楊振宇. "Adipocyte- and epidermal-fatty acid-binding proteins in relation to obesity and its medical complications". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B44204565.
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Ong, Kwok-leung, i 王國良. "Genetic variants of obesity- and inflammation-related genes in hypertension: genetic association studiesusing candidate gene approach". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45200555.
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Fuchs, Florent. "Obésité maternelle et macrosomie foetale : complications et prise en charge obstétricale". Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS037/document.
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Contexte : L'obésité est considérée par l'OMS comme une « épidémie » mondiale en raison de l'essor de sa prévalence et de ses conséquences sur la santé. Chez les patientes enceintes, son impact semble tout aussi préoccupant et sa prévalence en France atteint actuellement 10%. Certaines complications de l'obésité chez la femme enceinte ont été peu étudiées et notamment le lien particulier avec la macrosomie fœtale.Objectifs : Mieux appréhender la prise en charge des patientes enceintes obèses et de certaines complications qui en découlent.Méthodes : Trois séries de données différentes ont servi pour répondre à différentes questions sur la thématique de l'obésité et de la macrosomie. 1) Une évaluation de la faisabilité et de la qualité d'une échographie obstétricale du 2ème trimestre chez les patientes obèses a été réalisée via une étude mono centrique avec recueil prospectif des données. 2) Une étude des facteurs de risques de complications maternelles en cas d'accouchement d'un enfant macrosome, indépendamment de l'obésité maternelle et du poids de naissance de l'enfant a été menée sous la forme d'une étude prospective de cohorte d'enfant de plus de 4000g dans deux maternités d'Ile de France. 3) Enfin, une comparaison de la relation entre les complications maternelles de la grossesse et /ou néonatales et l'obésité a été menée entre la France (4 maternités de type III) et le Québec (données issues d'une étude randomisée dans toute la province) entre 2009 et 2011 via une étude comparative de deux échantillons transversaux de femmes enceintes (26 973 accouchements en France et 83 545 accouchements au Québec). Résultats : 1) Une échographie du deuxième trimestre de la grossesse chez une population obèse est possible, avec un taux de réussite en une fois de 70,4 %, (versus 82% ; p=0,08). Les facteurs d'amélioration de ce taux étaient : passer plus de temps lors de l'échographie (p=0,03), déplacer le fœtus de sorte que son dos soit en position latérale ou postérieure (p=0,01), et échographie réalisée par des échographistes expérimentés (p=0,03). Néanmoins, la qualité des images reste significativement moins bonne dans la population obèse (p=0,001). 2) La survenue de complications maternelles lors de la tentative d'accouchement vaginal d'un enfant de plus de 4000 g est de 6%. Les facteurs de risque de complications maternelles, outre le poids de naissance de l'enfant (p=0,004, Risque attribuable (RA)=10%), sont l'origine asiatique de la mère (p=0,04 ; RA=3%), une durée longue du travail (>10h) (p=0,02 ; RA=12%), et une césarienne au cours du travail (p=0,004 ; RA=17%). Les patientes multipares ayant déjà accouché par voie vaginale d'un enfant macrosome avaient un risque diminué de complications maternelles (p=0,03). 3) La prévalence de l'obésité était de 9,1% en France et 16,8% au Québec (p<0,001). L'obésité était associée de manière statistiquement significative (p<0,0001), à la fois en France et au Québec, à un risque accru de diabète gestationnel, de troubles hypertensifs de la grossesse, de prééclampsie, de mort fœtale in utero, d'accouchement par césarienne et de macrosomie. L'association était différente en France et au Québec (p interaction <0,005), pour la survenue du diabète gestationnel, de complications hypertensives de la grossesse et pour la macrosomie, avec une augmentation plus importante des complications avec l'IMC au Québec par rapport à la France.Conclusion : La compréhension de certaines complications inhérentes à l'obésité (complications médicales de la grossesse, faisabilité et qualité du dépistage échographique, complications obstétricales) est améliorée par les résultats de cette thèseBackground: According to WHO, obesity is considered as an "epidemic" condition due to the global growth of its prevalence and its impact on patient health. For pregnant patients, its impact seems equally worrying and its prevalence is now reaching 10% in France. Some complications of obesity in pregnant women have been little studied and particularly the special link with fetal macrosomia.Objectives: To better understand care and obstetric outcome of obese pregnant patients as well as some of their complications such as fetal macrosomia.Methods: Three different sets of data were used to deal with questions regarding obesity and macrosomia. 1) Assessment of feasibility and quality of second trimester ultrasound scan in obese patients was performed through a mono centric case-control study with prospective data collection. 2) A study of risk factors for maternal complications in case of the delivery of a macrosomic child, regardless of maternal obesity and child's birth weight, was conducted as a prospective cohort study including children with birthweight above 4000g in two “Ile de France” maternity wards. 3) Finally, a comparison of the relationship between maternal and/or neonatal complications of pregnancy and obesity was conducted in France (4 type III maternity wards) and in Quebec (data from a randomized study throughout the province) between 2009 and 2011 through a comparative study of two cross-sectional samples of pregnant women (26,973 births in France and 83,545 births in Quebec).Results: 1) Second trimester ultrasound scan in obese pregnant women is feasible, with a success rate of 70.4% (versus 82%; p=0.08). Factors of improvement were: to spend more time at ultrasound (p=0.03), to move the fetus so that its back is in lateral or posterior position (p=0.01) and when ultrasound was performed by experienced sonographers (p=0.03). However, the quality of the image remains significantly lower in the obese population (p=0.001). 2) The occurrence of maternal complications, when attempting vaginal birth of a child of more than 4000g, was 6%. Beyond childbirth weight (p=0.004, attributable risk (AR) = 10%), the risk factors of maternal complications were Asian ethnicity (p=0.04; AR=3%), prolonged labor (> 10h) (p=0.02; AR=12%), and caesarean section during labor (p=0.004; AR=17%). Multiparous women with a previous vaginal delivery of a macrosomic child had a lower risk of maternal complications (p=0.03). 3) The prevalence of obesity was 9.1% in France and 16.8% in Quebec (p <0.001). Obesity was significantly (p <0.0001) associated with, both in France and in Quebec, an increased risk of gestational diabetes, hypertensive disorders of pregnancy, preeclampsia, stillbirth, cesarean delivery and macrosomia. The strength of the association was different in France and Quebec (p of interaction <0.005) for the occurrence of gestational diabetes, hypertensive complications of pregnancy and macrosomia, with a larger increase in complications with body mass index in Quebec compared to France.Conclusion: Understanding some inherent complications of obesity (medical complications of pregnancy, feasibility and quality of ultrasound screening, obstetric complications) is enhanced by the result of this work
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Hayden, Wade Helen A. "A proposed psychosocial consequences model of childhood obesity /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3044785.
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Duncan, Elizabeth Karndu. "Obesity and its determinants in girls from five ethnic groups a thesis submitted to the Auckland University of Technology in fulfilment of the degree of Doctor of Philosophy, July 2008 /". Click here to access this resource online, 2008. http://hdl.handle.net/10292/463.
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Au, W. M. "Childhood obesity in Hong Kong medical and psychological sequelae /". Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971416.
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Harrison, Sarah. "Stereotyping and stigmatisation of obesity in young children". Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511127.
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Warren, Janet M. "Strategies for the prevention of obesity in children". Thesis, Oxford Brookes University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251367.
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Paisi, Martha. "Obesity and dental caries in children in Plymouth". Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/9582.
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Background: Obesity and dental caries are two of the most common conditions affecting children and both have significant implications on children’s wellbeing and future health. Even though research into the relationship between the two conditions has been conducted for many years, results to date remain equivocal. Furthermore, the majority of the studies only examined individual-level determinants of the two conditions. Aim: The current work aimed to examine the nature, direction and effect size of the relationship between obesity and caries in children in Plymouth, United Kingdom. It also aimed to better understand the individual and the broader environmental determinants of the two conditions. Methods: The study was divided into three parts: a systematic review examining the relationship between the two conditions in children and adolescents using a validated and study design specific tool; an analysis of extant data concerning Plymouth children’s weight status and dental caries using a spatial approach; and lastly a school survey of local children aged four to six years, where different types of obesity were examined in relation to dental caries. In the latter survey, several neighbourhood-level and individual characteristics were also examined in relation to the two conditions. Results: The systematic review indicated that there was no consistent association between high Body Mass Index and caries in individuals less than 18 years old. The ecological study identified spatial clusters of obesity and caries in Plymouth children and the results supported the importance of developing geographically focused prevention and intervention strategies which take into account the presence of spatial heterogeneity. The school survey did not find evidence of a relationship between any type of obesity and caries in Plymouth children but identified several indicators that affect the distribution of the two conditions. Conclusions: This work has given insight into the nature, direction and size of the relationship between obesity and caries in Plymouth children and has highlighted several indicators which need to be considered when developing local public health interventions.
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Sheu, Jiunn-jye. "Psychosocial antecedents of selected dietary behaviors among sixth grade Taiwanese children /". Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
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Boesch, Richard Paul. "Outcomes and complications of fundoplication in children with cystic fibrosis". Cincinnati, Ohio : University of Cincinnati, 2008. http://www.ohiolink.edu/etd/view.cgi?acc_num=ucin1204839634.
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Thesis (M.S. of Epidemiology)--University of Cincinnati, 2008.Advisor: Dr. James E Heubi. Title from electronic thesis title page (viewed May 12, 2008). Includes abstract. Keywords: fundoplication; cystic fibrosis; pulmonary function; nutrition. Includes bibliographical references.
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Charles, Hammond. "Neuropsychiatric complications of efavirenz in children with HIV-1 infection". Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29289.
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Background: Efavirenz is associated with transient neuropsychiatric manifestations but the impact on neurocognition is unknown. Genetically determined black South Africans who are slow metabolizers of efavirenz may be at risk of toxicity. This study describes neuropsychiatric and neurocognitive manifestations of South African children with suspected efavirenz neurotoxicity. Method: This retrospective study describes clinical features of 12 children with suspected efavirenz neurotoxicity (2008 – 2014). Results: Twelve children were referred (aged 3 years 4 months to 12 years, mean 7 years 8 months; 8 indigenous African (black) and 4 mixed ancestry). Six had acute neuropsychiatric manifestations after 2-8 weeks (mean 5 weeks) on efavirenz including drowsiness, seizures, sleep disturbances, behavioural changes, ataxia and slurred speech. Symptoms resolved over a few weeks in four. Two black children were phenotypically slow metabolizers with high plasma efavirenz concentrations above normal range resulting in discontinuation of efavirenz. Nine children had neurocognitive concerns potentially exacerbated by long-term efavirenz (6-72 months therapy; mean 31 months), and showed poor performance in all neurocognitive domains. Conclusion: Efavirenz causes transient neuropsychiatric adverse effects and may contribute to poor longterm neurocognitive outcomes in HIV-infected children. Genetically slow metabolizers are at risk of neurotoxicity. Prospective studies comparing efavirenz-treated and efavirenz-naïve children are needed.
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BOESCH, RICHARD PAUL. "Outcomes and complications of fundoplication in children with cystic fibrosis". University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204839634.
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Eaves, Audrey Denise Houmard Joseph A. "Effects of parental obesity on fat metabolism during submaximal exercise in children". [Greenville, N.C.] : East Carolina University, 2009. http://hdl.handle.net/10342/1905.
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Thesis (M.S.)--East Carolina University, 2009.Presented to the faculty of the Department of Exercise and Sport Science. Advisor: Joseph Houmard. Title from PDF t.p. (viewed May 4, 2010). Includes bibliographical references.
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Ebner, Jessica. "Raising awareness of school counselors regarding issues of childhood obesity". Online version, 2008. http://www.uwstout.edu/lib/thesis/2008/2008ebnerj.pdf.
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Misner, Scottie. "Promoting Healthy Weight in Children". College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2003. http://hdl.handle.net/10150/146447.
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Yang, Bo, i 杨波. "Role of lipocalin-2 in cardiac dysfunction associated with aging and dietary obesity". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47869641.
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Obesity is closely related to many medical complications such as type 2 diabetes,
hypertension and heart failure. Obesity and other factors, including elevated blood
glucose levels, hypertension, and dyslipidemia, constitute a constellation of symptoms
known as the metabolic syndrome, which are the risk factors for coronary artery
disease. Lipocalin-2 is a pro-inflammatory adipokine causally involved in the
development of obesity-associated metabolic and cardiovascular diseases. Recent
clinical and experimental evidences demonstrate an association between augmented
circulating lipocalin-2 and cardiac dysfunction. However, little is known about the
detailed roles of lipocalin-2 in regulating pathophysiological functions of the heart.
The present study was designed to compare the heart functions of mice with normal
(WT) or deficient lipocalin-2 (Lcn2-KO) expression and to examine the molecular
mechanisms underlying lipocalin-2-mediated deteriorated effects in hearts.
Echocardiographic analysis revealed that the myocardial contractile function was
significantly improved in hearts of Lcn2-KO mice, under both standard chow and
high fat diet conditions. The heart function before and after I/R injury (20-min of
global ischemia followed by 60-min of reperfusion) was assessed using the
Langendorff perfusion system. Compared with WT littermates, hearts from Lcn2-KO
mice showed improved functional recovery and reduced infarct size following I/R.
These phenomena can be observed in mice under both standard chow and high fat
feeding conditions.
Under baseline condition, the mitochondrial function of hearts from Lcn2-KO
mice was significantly enhanced, as demonstrated by biochemical analysis of
respiratory chain activity, markers of biogenesis and oxidative stress, as well as
electron microscopic investigation of the mitochondrial ultrastructure. Acute or
chronic administration of lipocalin-2 impaired cardiac functional recovery to I/R and
dampened the mitochondrial function in hearts of Lcn2-KO mice. These effects were
associated with an extensive modification of the fatty acyl chain compositions of
intracellular phospholipids. In particular, lipocalin-2 facilitated the redistribution of
linoleic acid (C18:2) among different types of phospholipid, including cardiolipin,
which is exclusively located in the mitochondria inner membrane.
The direct effects of lipocalin-2 on both H9c2 and NCM cells were also
examined. TUNEL assay and flow cytometry analysis demonstrated that lipocalin-2
treatment promoted apoptosis in cardiomyocytes. Lipocalin-2 induced an early phase
of phosphatidylserine exposure, followed by Bax-translocation and caspase-3
cleavage. The results collectively suggested that lipocalin-2 initiated the intrinsic
mitochondria-mediated apoptotic pathway. In the hearts of Lcn2-KO mice,
significantly reduced number of apoptotic cells was observed after I/R injury.
In conclusion, lacking of lipocalin-2 improved heart function recovery during I/R
injury via mitochondrial function restoration, phospholipids remodeling, and
inhibition of cardiomyocytes apoptosis.published_or_final_version
Pharmacology and Pharmacy
Doctoral
Doctor of Philosophy
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Sahu, Soumyadip. "Cross-talk of Leptin and Thrombospondin-1 in Atherosclerotic Complications". Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1492525184445034.
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Jones, Caroline Helen Dorothy. "Exploring the short-sleep obesity association in young children". Thesis, Durham University, 2011. http://etheses.dur.ac.uk/856/.
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There is strong and consistent epidemiological evidence that short sleep duration is associated with increased risk of obesity from early childhood. Childhood obesity and inadequate sleep have negative consequences for health and well-being, and the ability to target both of these public health concerns with a novel obesity intervention involving sleep extension is appealing; yet little is known about the mechanisms linking short sleep with obesity. In adults, hormonal mechanisms have been proposed; in young children, behavioural mechanisms and parenting are likely to be involved. Furthermore, the wider social and cultural determinants of short sleep and obesity should be incorporated into sleep-obesity research. This study aimed to explore some aspects of the sleep-obesity link in preschool children, using an exploratory design with a mixture of quantitative and qualitative methods, and applying an evolutionary medicine perspective. Participants were 109 3-year-old children and their parents in Stockton-on-Tees. Children’s sleep (validated by actigraphy), food intake and activity over 4 days/5 nights were assessed by parental diary report, and body composition was measured. Parents’ attitudes were explored using semi-structured interviews. Combined daytime and nighttime sleep duration was associated with central fat. Alternate parenting strategies were identified, based on regulation and consistency (routine-led), or child-governance and lack of regulation (routine-free). Building on the trends identified and the literature reviewed, I propose two hypotheses to explain the short sleep-obesity link in young children: the Behavioural Mechanisms Hypothesis (dietary and activity behaviours mediate or confound the association), and the Parental Confounding Hypothesis (parenting strategies, which vary with SES, impact on both children’s sleep duration and obesity risk). Parenting impacts children’s health by either limiting or facilitating discordance between children’s experiences in evolutionarily novel environments, and their biological make-up. I conclude that sleep-based obesity interventions should consider the wider context of children’s behaviours, particularly strategies of parenting.
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Hopman, Mariette Wilhelmina. "The psychological and social concomitants of obesity in children". Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239701.
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Kipping, Ruth. "Preventing obesity in children : developing a school-based intervention". Thesis, University of Bristol, 2010. http://hdl.handle.net/1983/82f67451-9d0a-4531-8aef-8b4b69c35372.
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The prevalence of childhood obesity has increased to epidemic proportions in Western Europe and North America. School-based interventions to prevent obesity have shown evidence of a reduction in the odds of obesity and weight, but most studies are from the US. The aims of this thesis are to examine the feasibility of transferring a US school based obesity prevention intervention for 9 to 10 year olds in England and to complete a feasibility study and pilot cluster randomised controlled trial of this intervention. The intervention is called 'Active for life year 5' (AFLY5). Using data from nationally representative surveys I found that obesity was at least 8% higher in US children aged 9-10 than English children. I found it is feasible and acceptable to adapt a US obesity prevention intervention to England. The intervention may lead to improvements in sedentary behaviour, physical activity, active travel to school, and eating healthy portions of fruit/vegetables, snacks and high energy drinks in English children. However, my pilot studies were too small to provide precise estimates that exclude the null. Homeworks engage some parents and may support behaviour change in a proportion of children. A sample size of 1300 children and 52 schools would be required for a full scale trial. A full-scale RCT of the intervention will provide robust evidence of the effectiveness of the intervention to decrease sedentary behaviour, increase physical activity and healthy eating. There are opportunities to integrate the intervention into existing public health initiatives.
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Fernandes, Raquel Alexandra Rodrigues. "Molecular mechanisms in obesity and intensive training in children". Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/22363.
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Mestrado em Biomedicina MolecularPhysical inactivity is a major risk for obesity. This chronic disease results from a caloric imbalance causing an enlargement of adipocytes by excessive fat storage. With an increasing prevalence, childhood obesity is correlated with endothelial dysfunction, inflammation and oxidative stress conducting to the development of other diseases not only in children but also during adulthood. In other hand, numerous children practice exercise of high duration or intensity in high competition sports, which can have harmful effects at physical, physiological and psychological level. In high competition young athletes, oxidative stress and immunosuppression can happen leading to an elevated risk of infection. However, an improved lipid profile is found in childhood athletes. Thus, the objective of the present study was to analyze the impact of childhood obesity as well as intense swimming training in body composition, inflammation and lipid profile, through blood analysis, bioimpedance and immunodetection of the pro-inflammatory cytokines (IL-6 and TWEAK), a myokine (Myostatin) and an acute-phase protein (CRP). For that, 24 young people were recruited into three groups: obese, athlete and lean. The obese group had high levels of body fat, an atypical lipid profile (low HDL and high LDL), high levels of lactate dehydrogenase in the blood indicating tissue damage, chronic inflammation (high IL-6, CRP and TWEAK) and low muscle mass (high Myostatin) without muscle damage (low CK). However, low serum levels of hepatic enzyme (AST and ALT) in these obese children do not associate obesity with liver disease. In other hand, intense physical exercise is not a harmfull activity for young athletes, since the lipid profile is improved and the increased levels of inflammatory markers is not significant. The main benefit of intensive training is the decreased levels of glucose being a protective role for diabetes.
A inatividade física é um dos principais riscos para a obesidade. Esta doença crónica resulta de um desiquilíbrio calórico causando um alargamento dos adipócitos através do excesso de armazenamento de gordura. Com um aumento da prevalência, a obesidade infantil correlaciona-se com a disfunção endotelial, inflamação e stress oxidativo, conduzindo ao desenvolvimento de outras doenças não só em criança, mas também durante a idade adulta. Por outro lado, muitas crianças praticam exercício de elevada duração ou intensidade em desportos de alta competição, o que pode ter efeitos prejudiciais a nível físico, fisiológico e psicológico. Em jovens atletas de alta competição, stress oxidativo e imunossupressão podem ocorrer levando ao elavado risco de infeção. No entanto, perfis lipídicos melhorados são encontrados em crianças atletas. Desta forma, o objetivo do presente estudo foi analizar o impacto da obesidade infantil bem como de treinos intensivos de natação na composição corporal, inflamação e perfil lipídico através de análises ao sangue, bioimpedância e imunodeteção de citocinas pró-inflamatórias (IL-6 e TWEAK), uma miocina (Miostatina) e uma proteina de fase aguda (CRP). Para tal, foram recrutados 24 jovens divididos em três grupos: obesos, atletas e normoponderais. O grupo de obesos apresentou elevados níveis de gordura corporal, um perfil lipídico atípico (baixo HDL e elevado LDL), níveis elevados de lactato desidrogenase no sangue indicando dano tecidual, inflamação crónica (elevado IL-6, CRP e TWEAK) e massa muscular diminuida (elevada Miostatina) sem dano muscular (baixo CK). No entanto os baixos níveis de enzimas hepáticas (AST e ALT) no soro não associam a obesidade com doença hepática. Por outro lado, o exercício físico intenso não é uma atividade prejudicial para os jovens atletas, uma vez que o perfil lipídico é melhorado e o aumento dos níveis de marcadores inflamatórios não é significativo. O principal benefício do treino intensivo é a diminuição dos níveis de glucose tendo um papel protetor para a diabetes.
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Onyeka, Uche. "Neighborhood-Level Predictors and Obesity Among African-American Children". ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4881.
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The steady raise in childhood obesity is a major public health problem nationally and globally. Childhood obesity is primarily caused by an imbalance between caloric intake and caloric expenditure. The increase in childhood obesity rates over the past 3 decades suggested involvement of environmental and behavioral factors in the obesity epidemic. While childhood obesity is considered a public health crisis in the United States, only limited research is available about the potential impact of neighborhood-level factors such as access to healthy food, neighborhood safety, and risk-free outdoor playgrounds. The purpose of this study was to examine if any relationships existed between childhood obesity and type of diet, level of physical activity, and neighborhood-level risk factors and childhood obesity. This study accessed the California Health Interview Survey (CHIS) 2009-2014 data sets. Chi-square tests and multivariate logistic regression were used to evaluate the associations between independent and dependent variables. The Wald test was used to assess the effects of each individual predictor, while adjusting for other predictors. The findings of this study showed no significant associations between childhood obesity and neighborhood safety; parental educational level; presence of parks, playgrounds, or open spaces; neighborhood walkability; neighborhood safety and support; and gender. Low physical activity levels, however were a significant risk factor for increase obesity. This study may lead to positive social change, enhancing individual lives and whole communities, by drawing the awareness of public health officials and policy makers to the importance of neighborhood factors associated with high body mass index.
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Ross, Kristie R. "Sleep Disordered Breathing, Obesity, and Asthma Severity in Children". Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1291296902.
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Basil, Janet S. "Retrospective Study of Obesity in Children with Down Syndrome". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882782.
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Alexander, Mary A., i Jacqueline Blank Sherman. "Factors Related to Obesity in Mexican American School Children". Mexican American Studies & Research Center, The University of Arizona (Tucson, AZ), 1992. http://hdl.handle.net/10150/624813.
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Paxton, Heather L. "The effects of childhood obesity on self-esteem". Huntington, WV : [Marshall University Libraries], 2005. http://www.marshall.edu/etd/descript.asp?ref=518.
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Lichtenfeld, Marc Jeremy. "Health transitions in school children overweight and obesity in Broome County, New York /". Diss., Online access via UMI:, 2009.
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Moore, Brie Ashley. "Examining FIT WEB a new approach to the conceptualization and treatment of pediatric obesity /". abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3258767.
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Boukhris, Tommy Tahar. "A public response to childhood obesity : evaluating the fresh fruit and vegetable program in Texas schools /". View online, 2007. http://ecommons.txstate.edu/arp/260/.
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Amir, Nili S. "Frequency of Complications Following Spinal Fusion in Children with Cerebral Palsy". eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1070.
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Background:
Neuromuscular Scoliosis is a frequent complication of Cerebral Palsy that requires surgical management including spinal fusion. The objective of this observational study was to describe differences in the frequency of postoperative complications in children with Cerebral Palsy following spinal fusion surgery compared to children with Idiopathic Scoliosis.
Methods:
The 2016 Kids’ Inpatient Database was queried to identify pediatric patients (old) with concurrent diagnoses of Cerebral Palsy and Neuromuscular Scoliosis undergoing spinal fusion surgery. Cases were compared to children without Cerebral Palsy and with a diagnosis of Idiopathic Scoliosis undergoing the same procedure. Fitted Poisson regression analysis with robust variance was performed to estimate relative risks in the frequency of various clinical complications while adjusting for several potentially confounding variables of importance.
Results:
A total of 660 cases and 5,244 comparators were identified. Compared to children with Idiopathic Scoliosis, children with Cerebral Palsy were younger (13.6 vs. 14.3 years), more likely to be male (54% vs. 23%), and more likely to have had governmental insurance (52% vs. 32%). They also had longer hospital lengths of stay (8 days vs. 4 days). After adjusting for a number of potentially confounding sociodemographic and clinical variables, children with Cerebral Palsy were more likely to have postoperative pulmonary, gastrointestinal, and surgical complications, receive blood transfusions, and be admitted to the ICU.
Conclusions:
Children with Cerebral Palsy have an increased risk of complications following spinal fusion surgery leading to longer hospital stays. These results further inform surgical decision-making and anticipatory guidance for these children and their caregivers.
46
McGloin, Aileen Frances. "Energy balance in children and lean children at high and low risk of obesity". Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274129.
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Matthews, Jenna Lynn. "Average beverage intake and average BMI in 2-5 year old WIC children". Huntington, WV : [Marshall University Libraries], 2002. http://www.marshall.edu/etd/descript.asp?ref=135.
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Chay, Wang George. "Thrombo-embolic complications and coagulation factor abnormalities in Chinese children after Fontan-type operation". Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971544.
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Newman, Lisa K. "The Association between BMI-for-age and Intra- and Post-General Anesthesia Airway Complications". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337213041.
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Nguyen, Thanh Wirat Kamsrichan. "Obesity and related factors among students grad 7-12 in Phuttha Monthon District, Nakhon Pathom Province, Thailand /". Abstract, 2008. http://mulinet3.li.mahidol.ac.th/thesis/2551/cd414/5038005.pdf.
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