Spis treści
Gotowa bibliografia na temat „Nuclear mitotic apparatus”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Zobacz listy aktualnych artykułów, książek, rozpraw, streszczeń i innych źródeł naukowych na temat „Nuclear mitotic apparatus”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Artykuły w czasopismach na temat "Nuclear mitotic apparatus"
Yang, C. H., i M. Snyder. "The nuclear-mitotic apparatus protein is important in the establishment and maintenance of the bipolar mitotic spindle apparatus." Molecular Biology of the Cell 3, nr 11 (listopad 1992): 1259–67. http://dx.doi.org/10.1091/mbc.3.11.1259.
Pełny tekst źródłaShima, David T., Noemí Cabrera-Poch, Rainer Pepperkok i Graham Warren. "An Ordered Inheritance Strategy for the Golgi Apparatus: Visualization of Mitotic Disassembly Reveals a Role for the Mitotic Spindle". Journal of Cell Biology 141, nr 4 (18.05.1998): 955–66. http://dx.doi.org/10.1083/jcb.141.4.955.
Pełny tekst źródłaPrice, Carolyn M., i David E. Pettijohn. "Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly". Experimental Cell Research 166, nr 2 (październik 1986): 295–311. http://dx.doi.org/10.1016/0014-4827(86)90478-7.
Pełny tekst źródłaJones, J. C., A. E. Goldman, H. Y. Yang i R. D. Goldman. "The organizational fate of intermediate filament networks in two epithelial cell types during mitosis." Journal of Cell Biology 100, nr 1 (1.01.1985): 93–102. http://dx.doi.org/10.1083/jcb.100.1.93.
Pełny tekst źródłaJohnston, J. A., i R. D. Sloboda. "A 62-kD protein required for mitotic progression is associated with the mitotic apparatus during M-phase and with the nucleus during interphase." Journal of Cell Biology 119, nr 4 (15.11.1992): 843–54. http://dx.doi.org/10.1083/jcb.119.4.843.
Pełny tekst źródłaTang, T. K., C. J. Tang, Y. J. Chao i C. W. Wu. "Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms". Journal of Cell Science 107, nr 6 (1.06.1994): 1389–402. http://dx.doi.org/10.1242/jcs.107.6.1389.
Pełny tekst źródłaPaul, E. C., i A. Quaroni. "Identification of a 102 kDa protein (cytocentrin) immunologically related to keratin 19, which is a cytoplasmically derived component of the mitotic spindle pole". Journal of Cell Science 106, nr 3 (1.11.1993): 967–81. http://dx.doi.org/10.1242/jcs.106.3.967.
Pełny tekst źródłaChu, Xiaogang, Xuanyu Chen, Qingwen Wan, Zhen Zheng i Quansheng Du. "Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle". Journal of Biological Chemistry 291, nr 38 (26.07.2016): 20055–67. http://dx.doi.org/10.1074/jbc.m116.724831.
Pełny tekst źródłaNguyen, Christine L., i Karl Münger. "Human Papillomavirus E7 Protein Deregulates Mitosis via an Association with Nuclear Mitotic Apparatus Protein 1". Journal of Virology 83, nr 4 (3.12.2008): 1700–1707. http://dx.doi.org/10.1128/jvi.01971-08.
Pełny tekst źródłaWozniak, Richard, Brian Burke i Valérie Doye. "Nuclear transport and the mitotic apparatus: an evolving relationship". Cellular and Molecular Life Sciences 67, nr 13 (8.04.2010): 2215–30. http://dx.doi.org/10.1007/s00018-010-0325-7.
Pełny tekst źródłaRozprawy doktorskie na temat "Nuclear mitotic apparatus"
Sparks, Cynthia A. "Cloning and Cell Cycle Analysis of NuMA, a Phosphoprotein That Oscillates Between the Nucleus and the Mitotic Spindle". eScholarship@UMMS, 1995. https://escholarship.umassmed.edu/gsbs_diss/35.
Pełny tekst źródłaRajeevan, Ashwathi. "Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells". Thesis, 2023. https://etd.iisc.ac.in/handle/2005/6078.
Pełny tekst źródłaHu, Hui-mei, i 胡惠美. "I. Genomic Organization and Promoter Analysis of the Mouse AIE1 Protein Kinase Gene II. The Expression and Functional Analysis of the Nuclear Mitotic Apparatus Protein (NuMA) During Early Mouse Embryonic Development". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/86586989699922791788.
Pełny tekst źródła國防醫學院
生命科學研究所
89
I. Genomic Organization and Promoter Analysis of the Mouse AIE1 Protein Kinase Gene We previously described two novel testis-specific protein kinases, AIE1 (mouse) and AIE2 (human), that share high amino acid (a.a.) identities with the kinase domains of fly Aurora, yeast Ipl1 and frog Eg2 (Tseng et al., 1998). Here we report the entire intron/exon organizations of the AIE1 gene and analyze the expression patterns of AIE1 mRNA during testis development. The cis-acting elements in the promoter region, and the transcription factors that may affect AIE1 expression, are also investigated. By screening a mouse genomic library, I have obtained the entire 18.5 kb AIE1 genomic sequence. The mouse AIE1 gene spans ~8 kilobases (kb) and contains seven exons. The results from primer extension assay indicated that the AIE1 gene has two transcription initiation sites: PE1 (minor form, -34 bp from 103d cDNA clone) and PE2 (major form, -18 bp from 103d cDNA clone). The sequences of the exon-intron boundaries of the AIE1 gene conform to the consensus sequences (GT/AG) of splicing donor and acceptor sites of most eukaryotic genes. Comparative sequence analysis revealed that the gene structure is highly conserved between mouse AIE1 and human AIE2. However, much less homology was found in the sequence outside the kinase domain. I have also mapped the AIE1 gene to mouse chromosome 7A2-A3 by fluorescent in situ hybridization (FISH). RT-PCR analysis has demonstrated that AIE1 mRNAs are predominantly expressed in testis, kidney, and sperm; but are not present in egg and in the embryonic tissues in early developmental stage. Northern blot analysis showed that AIE1 mRNA is expressed at a low level at day 14 and reaches its plateau at day 19 in the developing postnatal testis. RNA in situ hybridization indicated that the expression of AIE1 transcripts were restricted to meiotically active germ cells with highest levels detected in late pachytene spermatocytes. These findings suggest that AIE1 may play a role in spermatogenesis, particularly during the stages of meiosis. I have transfected a series of 5''-end deletion constructs of AIE1 promoter that fused with a luciferase reporter gene (AIE1p-Luc) into a mouse testis cell line to define the minimum region for AIE1 expression. My results showed that the promoter region (nt. -659 ~ -583) is essential for PE1 transcription initiation, while the region (nt. -442 ~ -343) is important for for PE2 transcription initiation. I also demonstrated that the Sp1/hsp70 binding site is necessary for PE2 transcription initiation and the CRE-like element (nt. -1093 ~ -1103) is essential for AIE1 expression. The influence of other transcription factors or protein kinases are analyzed by cotransfected with various deleted AIE1p-Luc constructs. My preliminary results showed that (1) PKA can avtivate, but MEKK-1 inhibit the AIE1p activity; (2) the l-TZFP is a repressor, but the s-TZFP is an activator. Furthermore, several specific transcription factors, such as TZFP (testis zinc finger protein) and CRE binding protein, that bind to the promoter region of AIE1 gene have been identified by the electrophoresis mobility shift assay (EMSA). The competition assay demonstrated the binding specificity. These results will help us to understand the control mechanism of AIE1 gene expression. II. The Expression and Functional Analysis of the Nuclear Mitotic Apparatus Protein (NuMA) During Early Mouse Embryonic Development The nuclear mitotic apparatus protein (NuMA) was first described by Lydersen and Pettijohn (1980) as a predominantly nuclear protein that is present in the interphase nucleus and is concentrated at the spindle pole of mitotic cells. Recently, cDNA clones that cover the entire coding region of human NuMA have been isolated and sequenced (Compton et al., 1992; Yang et al., 1992). Structure analysis reveals that NuMA is composed of a long a-helical central core flanked by two globular domains. We have recently shown that human NuMA is composed of at least three isoforms that differ mainly at the carboxy terminus. Multiple NuMA isoforms are generated by alternative splicing of a common mRNA precursor from a single NuMA gene (Tang et al., 1993). The NuMA-l (T33 / p230) was present in interphase nuclei and was concentrated at the polar regions of the spindle apparatus in mitotic cells. NuMA-m (U4 / p195) and NuMA-s (U6 / p194) were present in the interphase cytosol and appeared to be mainly located at the centrosomal region. When cells entered into mitosis, NuMA-m and -s moved to the mitotic spindle pole (Tang et al., 1994). In the mouse oocytes, the centrioles were reported to appear first in blastocysts (Magnuson and Epstein, 1984). Therefore, early mouse embryos offer an opportunity to elucidate the mechanisms of microtubule nucleation and spindle morphogenesis in the acentriolar centrosome. To investigate the expression patterns of different NuMA proteins or mRNAs during early mouse embryogenesis, the second part of my thesis is to clone and sequence the mouse homologue of human NuMA cDNA. By screening a mouse spleen cDNA library, I obtained the cDNA clones that cover the entire NuMA coding region. I also used the primer extension assay to define the transcription initiation site of NuMA mRNA. Furthermore, I have characterized the expression pattern of different NuMA isoforms in mouse tissues and during early stage of mouse embryonic development by RT-PCR method. My results showed that NuMA-l is present in all mouse tissues and in the 1.5 d.p.c. to 4.5 d.p.c. embryos. Interestingly, NuMA-m is expressed in all examined tissues except sperm, while NuMA-s is not detectable. Furthermore, the +42 bp NuMA isoform was detected in all tissues, while the -42 bp NuMA isoform was detected in testis and kidney only. To analyze the functional effect of NuMA on embryonic development, I injected mouse embryos with either antisense oligonucleotides (complementary to NuMA mRNA) or polyclonal antibodies against NuMA. Our results showed that injection of anti-NuMA antibody did significantly interfer the cell division during embryo-genesis. It suggested that NuMA may play a role in the cell division during early embryonic development.
Części książek na temat "Nuclear mitotic apparatus"
"NuMA (nuclear mitotic apparatus, centrophilin, ∼11q13)". W Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1380. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_11697.
Pełny tekst źródłaHe, D., C. Zeng i B. R. Brinkley. "Nuclear Matrix Proteins as Structural and Functional Components of the Mitotic Apparatus". W Structural and Functional Organization of the Nuclear Matrix, 1–74. Elsevier, 1996. http://dx.doi.org/10.1016/s0074-7696(08)62614-5.
Pełny tekst źródłaPettijohn, David E. "Nonhistone Chromosomal Proteins of the Mitotic Apparatus: Proposed Role in Nuclear Reassembly". W Progress in Nonhistone Protein Research, 139–50. CRC Press, 2018. http://dx.doi.org/10.1201/9781351076067-7.
Pełny tekst źródłaTang, Chieh-ju C., i Tang K. Tang. "Subcellular Localization and Gene Mapping of Human Nuclear Mitotic Apparatus Protein (NuMA) by Confocal Fluorescence Microscopy". W Focus on Multidimensional Microscopy, 220–32. World Scientific Publishing Co., 1999. http://dx.doi.org/10.1142/9789812817105_0016.
Pełny tekst źródła