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Artykuły w czasopismach na temat "NOS2A"
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Lepiller, Sandrine, Nathalie Franche, Eric Solary, Johanna Chluba i Véronique Laurens. "Comparative analysis of zebrafish nos2a and nos2b genes". Gene 445, nr 1-2 (wrzesień 2009): 58–65. http://dx.doi.org/10.1016/j.gene.2009.05.016.
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Bloch, Kenneth D., Johanna R. Wolfram, Donna M. Brown, Jesse D. Roberts, David G. Zapol, John J. Lepore, Galina Filippov, Jeffrey E. Thomas, Howard J. Jacob i Donald B. Bloch. "Three Members of the Nitric Oxide Synthase II Gene Family (NOS2A, NOS2B, and NOS2C) Colocalize to Human Chromosome 17". Genomics 27, nr 3 (czerwiec 1995): 526–30. http://dx.doi.org/10.1006/geno.1995.1086.
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Chai, Jun, Qinglu Wang, Bo Qin, Shengkui Wang, Youtao Wang, Muhammad Shahid, Kai Liu, Yifang Zhang i Weijie Qu. "Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle". PLOS ONE 16, nr 6 (17.06.2021): e0253339. http://dx.doi.org/10.1371/journal.pone.0253339.
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Bovine tuberculosis (bTB) is a global zoonotic disease that has detrimental economic impacts worldwide. The NOS2A gene plays a key role in immunological control of many infectious diseases. However, research on the association between NOS2A polymorphisms and bTB infection in Holstein cattle reared on the Yunnan-Guizhou plateau of China is scarce. This study investigated a possible linkage between NOS2A polymorphisms and risk of developing bTB in Chinese Holstein cattle. The NOS2A gene was genotyped in 144 bTB-infected Holstein cows and 139 healthy controls were genotyped through nucleotide sequencing. Ten single-nucleotide polymorphisms (SNPs) were detected, six of which were associated with susceptibility/resistance patterns of bTB. Furthermore, the C/T genotypes of 671 and 2793, and T/T genotype of E22 (+15) were significantly associated with susceptibility risk; the G/A genotype of 2857, T/T genotype of E9 (+65), and C/C genotype of E9 (+114) probably increased resistance to bTB. In addition, the haplotypes of NOS2A-2 and NOS2A-9 were risk factors for bTB susceptibility, while the NOS2A-5 and NOS2A-8 haplotypes were contributing protective variants against tuberculosis. There is a significant association between variation in SNPs of NOS2A and tuberculosis susceptibility/resistance pattern. These findings suggest that substitution of genetic selection would be helpful for eradicating bTB. However, further investigation is required to study the underlying mechanism through which NOS2A polymorphisms affect bTB infection.
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Tsutsumi, Seiji, Xi Zhang, Keiko Takata, Kazuhiro Takahashi, Richard H. Karas, Hirohisa Kurachi i Michael E. Mendelsohn. "Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2". Journal of Endocrinology 199, nr 2 (27.08.2008): 267–73. http://dx.doi.org/10.1677/joe-07-0292.
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Estrogen has both rapid and longer term direct effects on cardiovascular tissues mediated by the two estrogen receptors, ESR1 and ESR2. Previous work identified that estrogen regulates the expression of inducible nitric oxide synthase (NOS2A) in vascular smooth muscle cells (VSMC). ESR2 knockout mice have vascular dysfunction due to dysregulation of NOS2A expression and these mice are hypertensive (Zhu et al. Science 2002 295 505–508). Here, we report studies to examine the differential regulation of NOS2A gene expression by ESR1 and 2. Immunoblotting and RT-PCR studies revealed that different VSMC lines expressed different levels of ESR1 and ESR2 protein and mRNA. VSMC from different vascular beds were studied, including aortic VSMC expressing ESR1 and radial (Rad) VSMC expressing ESR2. E2 inhibited NO production and NOS2A protein expression in aortic VSMC. Human NOS2A promoter–reporter studies revealed suppression of NOS2A reporter activity by E2 in aortic VSMC, and stimulation of NOS2A reporter activity by E2 in Rad arterial VSMC. In heterologous expression studies of COS-7 cells lacking endogenous ER, E2 treatment of COS-7 cells did not alter NOS2A reporter activity in the presence of ESR1, while reporter activity increased 2.3-fold in the presence of ESR2. Similar experiments in COS-7 cells using the selective estrogen receptor modulator raloxifene showed that raloxifene caused a reduction in NOS2A reporter activity with ESR1 coexpression and an increase with ESR2 coexpression. Rat VSMC expressing ESR2 but not ESR1 also showed increased NOS2A reporter activity with E2 treatment, an effect lost when ESR1 was introduced into the cells. Taken together, these data support that hNOS2A transcription is regulated positively by ESR2 and negatively by ESR1 in VSMC, supporting differential actions of these two estrogen receptors on a physiologically relevant gene in VSMC.
5
Gogna, Rajan, Esha Madan i Periannan Kuppusamy. "RPA-Dependent Melting of Triplex DNA at NOS2a Gene Promoter is Indispensible for p53-Mediated NOS2a Synthesis and Cardioprotection". Free Radical Biology and Medicine 53 (listopad 2012): S168. http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.460.
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Batozhargalova, B. Ts, Yu L. Mizernitsky, S. E. Dyakova, N. V. Petrova i R. A. Zinchenko. "Clinical and genetic associations of NO-synthase and arginase gene polymorphisms and gene-gene interactions in children with bronchial asthma". Voprosy praktičeskoj pediatrii 15, nr 5 (2020): 7–17. http://dx.doi.org/10.20953/1817-7646-2020-5-7-17.
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Objective. To analyze the association between NOS1, NOS2, NOS3, ARG1, and ARG2 gene polymorphisms and clinical, laboratory, and functional characteristics of bronchial asthma (BA) in children by evaluating gene-gene interactions. Patients and methods. We have evaluated the associations between the NOSs and ARG genes and gene-gene interactions in 107 children with BA. We performed comparative genetic analysis of associations between polymorphic variants of candidate genes in 107 BA patients and clinical manifestations of the disease, laboratory, and functional parameters. Results. We have found an association between the short (S) allele and SS genotype of the NOS1 (AAT)n gene and early disease onset (<5 years), severe BA, and antiinflammatory targeted therapy (with omalizumab and combination inhaled corticosteroids with long-acting β2-agonists). We have also revealed an association between the short (S) allele and SS genotype of the NOS1 (AAT)n gene, as well as long (L) alleles and LL genotypes of the NOS2A (CCTTT)n gene in BA patients and elevated FeNO levels in the exhaled air. The following association have also been identified: between alleles and genotypes containing long (L) tandem repeats in the NOS2A (CCTTT)n gene and reduced FEV1; between AG genotype of the ARG2 gene (rs3742879), alleles and genotypes containing long tandem repeats (L) of the NOS2А (CCTTT)n gene and reduced FEV1/ FVC; between alleles and genotypes containing long tandem repeats (L), combinations of genotypes SL+LL of the NOS2А (CCTTT)n and impaired patency at the level of the middle bronchi FEF50; between allele G, heterozygous genotype AG of the ARG2 (rs3742879) gene with impaired patency at the level of peripheral bronchi FEF75. Conclusion. Our analysis of gene-gene interactions has demonstrated phenotypic characteristics of BA: early BA onset, severe BA, decreased FEV1 and FEF50, increased NO concentration in exhaled air, and presence of fungal and epidermal sensitization. Key words: children, bronchial asthma, NOS and ARG gene polymorphisms, gene-gene interactions
7
De Luca, Chiara, Agnese Gugliandolo, Carlo Calabrò, Monica Currò, Riccardo Ientile, Desanka Raskovic, Ludmila Korkina i Daniela Caccamo. "Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances". Mediators of Inflammation 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/245308.
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Oxidative stress and inflammation play a pathogenetic role in idiopathic environmental intolerances (IEI), namely, multiple chemical sensitivity (MCS), fibromyalgia (FM), and chronic fatigue syndrome (CFS). Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A −2.5 kb (CCTTT)nas well as Ser608Leu and NOS3 −786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects. Patients and controls had similar distributions of NOS2A Ser608Leu and NOS3 −786T>C polymorphisms. Interestingly, the NOS3 −786TT genotype was associated with increased nitrite/nitrate levels only in IEI patients. We also found that the NOS2A −2.5 kb (CCTTT)11allele represents a genetic determinant for FM/CFS, and the (CCTTT)16allele discriminates MCS from SMCS patients. Instead, the (CCTTT)8allele reduces by three-, six-, and tenfold, respectively, the risk for MCS, SMCS, and FM/CFS. Moreover, a short number of (CCTTT) repeats is associated with higher concentrations of nitrites/nitrates. Here, we first demonstrate that NOS3 −786T>C variant affects nitrite/nitrate levels in IEI patients and that screening for NOS2A −2.5 kb (CCTTT)npolymorphism may be useful for differential diagnosis of various IEI.
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Varadé, Jezabel, José Ramón Lamas, Miguel Fernández-Arquero, Juan Ángel Jover, Emilio G. de la Concha, Alfonso Martínez, Benjamín Fernández-Gutierrez i Elena Urcelay. "NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis". Nitric Oxide 21, nr 3-4 (grudzień 2009): 171–74. http://dx.doi.org/10.1016/j.niox.2009.07.005.
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Xu, Weiming, Steve Humphries, Masafumi Tomita, Toshiko Okuyama, Michihiro Matsuki, David Burgner, Dominic Kwiatkowski, Lizhi Liu i Ian G. Charles. "Survey of the Allelic Frequency of a NOS2A Promoter Microsatellite in Human Populations: Assessment of the NOS2A Gene and Predisposition to Infectious Disease". Nitric Oxide 4, nr 4 (sierpień 2000): 379–83. http://dx.doi.org/10.1006/niox.2000.0290.
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Schulte, C., M. Sharma, J. C. Mueller, P. Lichtner, J. Prestel, D. Berg i T. Gasser. "Comprehensive association analysis of the NOS2A gene with Parkinson disease". Neurology 67, nr 11 (11.12.2006): 2080–82. http://dx.doi.org/10.1212/01.wnl.0000247672.41736.bd.
Pełny tekst źródłaRozprawy doktorskie na temat "NOS2A"
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Silveira, VirgÃnia RÃgia Souza da. "Polimorfismos nos genes interleucina10, NOS2A e ESR2 em portadores de periodontite crÃnica e agressiva". Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13821.
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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel SuperiorConselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
Alguns mediadores inflamatÃrios como a interleucina-10 (IL-10), a molÃcula do Ãxido nÃtrico (NO) e o hormÃnio estrÃgeno parecem participar do processo inflamatÃrio da doenÃa periodontal (DP). Este trabalho teve por objetivo: 1) revisar a relaÃÃo coma DP da IL-10, NO e estrÃgeno, assim como polimorfismos presentes nesses genes, respectivamente: IL10, isoformas das Ãxido nÃtrico sintases (NOS) e receptores de estrÃgeno (ESR) (capÃtulo 1); 2) investigar a associaÃÃo dos genes IL10, NOS2A e ESR2 na periodontite crÃnica (PC) e agressiva (PAg) (capÃtulo 2); 3) avaliar o tratamento periodontal prÃvio (TPP) e hÃbitos de higiene oral em portadores de periodontite agressiva generalizada (PAgG) (capÃtulo3). No estudo 1, foi realizada uma revisÃo de literatura incluindo estudos clÃnicos em humanos, com publicaÃÃes na lÃngua inglesa, que investigaram o papel da IL-10, do NO e estrÃgeno e polimorfismos genÃticos relacionados a esses mediadores na DP. No estudo 2, foram investigados os SNPs (Single Nucleotide Polymorphism ou polimorfismos de base Ãnica) -1087G>A (rs1800896), -819C>T (rs1800871) e -592C>A (rs1800872) no promotor do gene IL10, +2087G>A (rs2297518) no gene NOS2A e +1730G>A (rs4986938) no gene ESR2 em 50 pacientes com PAg, 61 pacientes com PC e 61 pacientes-controle. No estudo 3, foram avaliados 55 pacientes com PAgG mediante exame clÃnico periodontal, hÃbitos de higiene oral e tratamento periodontal prÃvio (TPP). Os resultados mostraram no estudo 1, que nÃveis elevados de IL-10 e NO estÃo correlacionados com a PC. Foram encontradas associaÃÃes dos SNPs -592 e -819 do gene IL10 com a periodontite crÃnica e do haplÃtipo ATA com a periodontite crÃnica e agressiva. Existem evidÃncias positivas do uso da terapia de reposiÃÃo com estrÃgeno sobre os tecidos periodontais em mulheres na pÃs-menopausa. No estudo 2, o genÃtipo +2087GG no gene NOS2A mostrou tendÃncia a uma associaÃÃo significante com a DP (p= 0,05; OR= 0,44; 95% IC= 0,20-0,95). NÃo foram encontradas associaÃÃes com DP na anÃlise de genÃtipos dos genes IL10 e ESR2 ou haplÃtipos do gene IL10. No estudo 3 os pacientes que nÃo utilizavam o fio dental apresentavam uma chance reduzida em 84% de terem realizado TPP (p= 0,005; OR= 0,16; 95% IC= 0,04-0,59). Conclui-se que concentraÃÃes elevadas de IL-10 e NO podem ser encontradas nos tecidos periodontais inflamados e existem associaÃÃes dos polimorfismos genÃticos no promotor do gene Interleucina-10 com a periodontite crÃnica e agressiva. IndivÃduos que carregam o genÃtipo GG no SNP +2087 do gene NOS2A tendem a serem mais protegidos contra o desenvolvimento de DP. Nos pacientes com PAgG houve uma relaÃÃo significativa entre o uso de fio dental e a presenÃa de TPP.
Some inflammatory mediators such as interleukin-10 (IL-10), the molecule of nitric oxide (NO) and the hormone estrogen can participate in the inflammatory periodontal disease (PD). This study aimed to: 1) review the relationship of IL 10, NO and estrogen as well as genetic polymorphisms linked to genes encoding IL 10, isoforms of NOS and estrogen receptors with the DP (Chapter 1); 2) to investigate the association of IL-10, NOS2A and ESR2 genes in chronic periodontitis (CP) and aggressive (AP) (Chapter 2); 3) assess the relationship between prior periodontal treatment (PPT) e oral hygiene habits in patients with generalized aggressive periodontitis (GAP) (chapter 3). In study 1 was carried out a literature review and included clinical studies in humans, with publications in the English language that investigated the role of IL 10, NO and estrogen and related genetic polymorphisms in PD. In study 2 were investigated SNPs (single nucleotide polymorphisms) -1087G> A (rs1800896), -819C> T (rs1800871) and -592C> A (rs1800872) in the IL10 gene, + 2087G> A (rs2297518) in NOS2A gene and + 1730G> A (rs4986938) in ESR2 gene in 50 AP patients, 61 CP patients and 61 control patients. In study 3, 55 patients with generalized aggressive periodontitis (GAP) were analyzed through clinical periodontal examination and collection of data of oral hygiene and prior periodontal treatment (PPT). Study 1 showed that levels of IL 10 and NO are correlated with the PC. Associations were found for SNPs -592 and -819 of the IL 10 gene with chronic periodontitis and haplotype ATA with chronic and aggressive periodontitis. There is positive evidence of the use of replacement therapy with estrogen on the periodontal tissues in postmenopausal women. In study 2 patients with genotype + 2087GG in NOS2A gene showed a trend toward a significant association with PD (p = 0.05; OR = 0.44; 95% CI = 0.20 to 0.95). There were no significant associations with PD in the genotype analysis of IL 10 and ESR2 genes or haplotypes of IL 10 gene. In study 3 patients who did not use dental floss had a reduced chance in 84% of undergoing TPP (p = 0.005; OR = 0.16; 95% CI = 0.04 to 0.59). It is concluded that high concentrations of IL-10 and NO can be found in inflamed periodontal tissues. Subjects with the GG genotype in the SPN +2087 NOS2A gene were protected against the development of PD. There was a significant relationship between the use of dental floss and the presence of previous periodontal treatment.
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Silveira, Virgínia Régia Souza da. "Polimorfismos nos genes interleucina10, NOS2A e ESR2 em portadores de periodontite crônica e agressiva". reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/15538.
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SILVEIRA, Virgínia Régia Souza da. Polimorfismos nos genes interleucina10, NOS2A e ESR2 em portadores de periodontite crônica e agressiva. 2015. 98 f. Tese (Doutorado em Odontologia) - Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, 2015.Submitted by denise santos (denise.santos@ufc.br) on 2016-03-17T11:37:57Z No. of bitstreams: 1 2015_tese_vrssilveira.pdf: 1561293 bytes, checksum: 0a986c2265513567ad7dcd0581acee92 (MD5)
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Some inflammatory mediators such as interleukin-10 (IL-10), the molecule of nitric oxide (NO) and the hormone estrogen can participate in the inflammatory periodontal disease (PD). This study aimed to: 1) review the relationship of IL 10, NO and estrogen as well as genetic polymorphisms linked to genes encoding IL 10, isoforms of NOS and estrogen receptors with the DP (Chapter 1); 2) to investigate the association of IL-10, NOS2A and ESR2 genes in chronic periodontitis (CP) and aggressive (AP) (Chapter 2); 3) assess the relationship between prior periodontal treatment (PPT) e oral hygiene habits in patients with generalized aggressive periodontitis (GAP) (chapter 3). In study 1 was carried out a literature review and included clinical studies in humans, with publications in the English language that investigated the role of IL 10, NO and estrogen and related genetic polymorphisms in PD. In study 2 were investigated SNPs (single nucleotide polymorphisms) -1087G> A (rs1800896), -819C> T (rs1800871) and -592C> A (rs1800872) in the IL10 gene, + 2087G> A (rs2297518) in NOS2A gene and + 1730G> A (rs4986938) in ESR2 gene in 50 AP patients, 61 CP patients and 61 control patients. In study 3, 55 patients with generalized aggressive periodontitis (GAP) were analyzed through clinical periodontal examination and collection of data of oral hygiene and prior periodontal treatment (PPT). Study 1 showed that levels of IL 10 and NO are correlated with the PC. Associations were found for SNPs -592 and -819 of the IL 10 gene with chronic periodontitis and haplotype ATA with chronic and aggressive periodontitis. There is positive evidence of the use of replacement therapy with estrogen on the periodontal tissues in postmenopausal women. In study 2 patients with genotype + 2087GG in NOS2A gene showed a trend toward a significant association with PD (p = 0.05; OR = 0.44; 95% CI = 0.20 to 0.95). There were no significant associations with PD in the genotype analysis of IL 10 and ESR2 genes or haplotypes of IL 10 gene. In study 3 patients who did not use dental floss had a reduced chance in 84% of undergoing TPP (p = 0.005; OR = 0.16; 95% CI = 0.04 to 0.59). It is concluded that high concentrations of IL-10 and NO can be found in inflamed periodontal tissues. Subjects with the GG genotype in the SPN +2087 NOS2A gene were protected against the development of PD. There was a significant relationship between the use of dental floss and the presence of previous periodontal treatment.
Alguns mediadores inflamatórios como a interleucina-10 (IL-10), a molécula do óxido nítrico (NO) e o hormônio estrógeno parecem participar do processo inflamatório da doença periodontal (DP). Este trabalho teve por objetivo: 1) revisar a relação coma DP da IL-10, NO e estrógeno, assim como polimorfismos presentes nesses genes, respectivamente: IL10, isoformas das óxido nítrico sintases (NOS) e receptores de estrógeno (ESR) (capítulo 1); 2) investigar a associação dos genes IL10, NOS2A e ESR2 na periodontite crônica (PC) e agressiva (PAg) (capítulo 2); 3) avaliar o tratamento periodontal prévio (TPP) e hábitos de higiene oral em portadores de periodontite agressiva generalizada (PAgG) (capítulo3). No estudo 1, foi realizada uma revisão de literatura incluindo estudos clínicos em humanos, com publicações na língua inglesa, que investigaram o papel da IL-10, do NO e estrógeno e polimorfismos genéticos relacionados a esses mediadores na DP. No estudo 2, foram investigados os SNPs (Single Nucleotide Polymorphism ou polimorfismos de base única) -1087G>A (rs1800896), -819C>T (rs1800871) e -592C>A (rs1800872) no promotor do gene IL10, +2087G>A (rs2297518) no gene NOS2A e +1730G>A (rs4986938) no gene ESR2 em 50 pacientes com PAg, 61 pacientes com PC e 61 pacientes-controle. No estudo 3, foram avaliados 55 pacientes com PAgG mediante exame clínico periodontal, hábitos de higiene oral e tratamento periodontal prévio (TPP). Os resultados mostraram no estudo 1, que níveis elevados de IL-10 e NO estão correlacionados com a PC. Foram encontradas associações dos SNPs -592 e -819 do gene IL10 com a periodontite crônica e do haplótipo ATA com a periodontite crônica e agressiva. Existem evidências positivas do uso da terapia de reposição com estrógeno sobre os tecidos periodontais em mulheres na pós-menopausa. No estudo 2, o genótipo +2087GG no gene NOS2A mostrou tendência a uma associação significante com a DP (p= 0,05; OR= 0,44; 95% IC= 0,20-0,95). Não foram encontradas associações com DP na análise de genótipos dos genes IL10 e ESR2 ou haplótipos do gene IL10. No estudo 3 os pacientes que não utilizavam o fio dental apresentavam uma chance reduzida em 84% de terem realizado TPP (p= 0,005; OR= 0,16; 95% IC= 0,04-0,59). Conclui-se que concentrações elevadas de IL-10 e NO podem ser encontradas nos tecidos periodontais inflamados e existem associações dos polimorfismos genéticos no promotor do gene Interleucina-10 com a periodontite crônica e agressiva. Indivíduos que carregam o genótipo GG no SNP +2087 do gene NOS2A tendem a serem mais protegidos contra o desenvolvimento de DP. Nos pacientes com PAgG houve uma relação significativa entre o uso de fio dental e a presença de TPP.
3
Tajouri, Lotfi, i n/a. "Gene Expression Analysis and Genetic Studies in Multiple Sclerosis". Griffith University. School of Health Science, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20060111.123933.
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Multiple Sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). As part of this disorder the myelin sheath undergoes degeneration, leading to alterations in the conductivity of axons, and impaired function. The onset of the disease occurs in young adults and clinical pathology is characterised by varying severity. These include i) Relapsing Remitting MS (RR-MS), ii) Secondary Progressive MS (SP-MS) and iii) Primary Progressive MS (PP-MS). MS is more prevalent in women and accounts for more than two thirds of all MS sufferers. MS is considered to be a multifactorial disorder with both genetic and environmental components. The prevalence of MS is dependent on geographical localisation, with lower sunlight exposure linked to higher prevalence. Also, studies show an increased risk in close relatives, or in identical twins, indicating a significant genetic component to the disorder. There are a number of genes that may plausibly be involved in MS pathophysiology. These include myelin-related genes, such as the myelin basic protein (MBP), immune-related genes, such FC receptor and osteopontin, and heat shock proteins such as xb crystallin. These candidate genes have been implicated in a variety of ways but usually through immunological and/or genetic studies. One of the most consistent findings in recent years has been the association of disease with alterations in the specific major histocompatibility complex (MHC) localised to chromosome 6p21.3, and includes MHC I, II, III. Genome wide screens have permitted the identification of loci in the genome, which are associated with MS susceptibility. The number of genes involved in MS is unknown and several case-control association studies have been undertaken to reveal the involvement of potential candidate genes. In general terms, current research is aimed at determining allelic variation of candidate genes. Such genes have been implicated in MS because they reside within susceptible regions of the chromosome associated with MS or they have a plausible potential pathophysiological role in MS. Candidate loci investigated in this study, for association with MS susceptibility, include members of the nitric oxide synthase family of metabolic proteins (inducible NOS, iNOS/NOS2A and neuronal NOS, nNOS), methylenetetrahydrofolate reductase (MTHFR), catechol-O-methyl transferase (COMT), and vitamin D receptor (VDR). The MS population used in all studies consisted of over 100 MS cases and gender, age and ethnicity matched controls. In our study of inducible and neuronal NOS genes, PCR based assays were developed to amplify a region of both promoters that contained known microsatellite variation. Supporting phyisological data suggests that the neuroinflammatory aspects of MS are associated with aberrant NO production, which may be due to aberrant regulation of NOS activity. Specific amplified products were identified by fluorescent capillary electrophoresis and allele frequencies were statistically compared using chi-squared analysis. In the nNOS and iNOS study, no association was identified with allele frequency variation and MS susceptibility (nNOS: ?2=5.63, P=0.962; iNOS: ?2=3.4; P=0.082). Similarly, no differences in allele frequencies were observed for gender or clinical course for both markers (Pvalue greater than 0.05). In short, results from this study indicate that the NOS promoter variations studied do not play a significant role in determining susceptibility to MS in the tested population. The COMT and MTHFR genes are localised at 22q12-13 and 1p36.3 respectively, regions of the genome that have been found to be positively associated with MS susceptibility. In our research, we set out to examine the G158A change in the 4th exon of the COMT gene. This functional mutation leads to an amino acid change (valine to methionine) that is directly associated with changes in the activity of COMT. The MTHFR enzyme plays a role in folate metabolism, and can be implicated in the turnover of homocysteine. Previous investigations have shown that high levels of homocysteine are encountered in MS patients, where it is also linked to demyelination in the CNS. In our study the aim was to examine the C677T variation (alanine to valine amino acid change) in the exon 4 coding region of the MTHFR gene and the G158A variation in the COMT gene. Restriction fragment length polymorphism (RFLP) analysis and gel electrophoresis was used to identify specific alleles for both COMT and MTHFR. However, as with the NOS study, no specific association was identified between MS susceptibility and variation for either of the tested COMT or MTHFR (Pvalue greater than 0.05) variants. In a final genomic investigation of the MS population, three variations in the VDR gene were analysed for association with MS susceptibility and pathology. Using RFLP analysis, three VDR variants were investigated with genotypes detected using the Taq I, Apa I and Fok I restriction enzymes. In contrast to previous genotypic analyses, this study did show a positive association, specifically between the functional variation in exon 9 of the VDR gene and MS (Taq I, 2= 7.22, P= 0.0072). Interestingly, the Apa I variant of VDR was also found to be associated with MS ( 2=4.2, P=0.04). The Taq I and Apa I variants were also found to be in very strong and significant linkage disequilibrium (D'=0.96, Pvalue less than 0.0001) and their associations were more prominent with the progressive forms of MS (SP-MS and PP-MS). In addition to genotypic analysis of a clinical population, additional research was undertaken to identify novel targets for MS susceptibility studies. Global gene expression analysis was undertaken using comparative subtractive fluorescent microarray technology to examine differences in gene activity (expression) in age and sex matched MS plaque tissue and anatomically matched normal white matter (NWM). MS plaques were obtained post mortem from MS sufferers with no drug history in the last two months before death and matched anatomically to healthy white matter from donors with no previous neurological disorders. Target arrays consisted of 5000 cDNAs and analysis was conducted using the Affymetrix 428 scanner. In this way, 139 genes were shown to be differentially regulated in MS plaque tissue compared to NWM. Of these, 69 genes showed a common pattern of expression in the chronic active and acute plaque tissues investigated (Pvalue less than 0.0001, a=0.73); while 70 transcripts were uniquely differentially expressed ( 1.5-fold) in either acute or chronic active lesions. To validate the gene expression profile results, quantitative real time reverse transcriptase (RT) PCR (Q-PCR) analysis was performed. 12 genes were selected because they were shown to be differentially expressed by array analysis in this study, or because of their involvement in MS pathology. These included transferrin (TF), superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPX1), glutathione S-transferase pi (GSTP1), crystallin, alpha-B (CRYAB), phosphomannomutase 1 (PMM1), tubulin beta-5 (TBB5), inositol 1,4,5-trisphosphate 3-kinase B (ITPKB), calpain 1 (CAPNS1), osteopontin (SPP1 or OPN), as well as the signal transducer and activator of transcription 1 (STAT1) and protein inhibitor of activated STAT1 (PIAS1). Both absolute (copy number) and comparative differences in the relative levels of expression in MS lesions and NWM were determined for each gene. The results from this study revealed a significant correlation of real time PCR results with the microarray data, while a significant correlation was also found between comparative and absolute determinations of fold. As with the results of array analysis, a significant difference in gene expression patterning was identified between chronic active and acute plaque pathologies. For example, a up to 50-fold increase in SPP1 and ITPKB levels in acute plaques contrasted with the 5-fold or less increase in chronic active plaques (P less than 0.0.1, unpaired t-Test). Of particular note, gamma-amino butyric acid receptor ?2 (GABG2), integrin ?5 (ITGB5), complement component 4B (C4B), parathyroid hormone receptor 1 (PTHR1) were found up-regulated in MS and glial derived neurotropic factor ?2 (GDNFA2), insulin receptor (INSR), thyroid hormone receptor ZAKI4 (ZAKI4) were found down-regulated in MS. Data also revealed a decreased expression of the immune related genes STAT1 and PIAS1 in acute plaques. In conclusion, this research used both genomic analysis and technologies in gene expression to investigate both known and novel markers of MS pathology and susceptibility. The study developed tools that may be used for further investigation of clinical pathology in MS and have provided interesting initial expression data to further investigate the genes that play a role in MS development and progression.
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Tajouri, Lotfi. "Gene Expression Analysis and Genetic Studies in Multiple Sclerosis". Thesis, Griffith University, 2005. http://hdl.handle.net/10072/366467.
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Multiple Sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). As part of this disorder the myelin sheath undergoes degeneration, leading to alterations in the conductivity of axons, and impaired function. The onset of the disease occurs in young adults and clinical pathology is characterised by varying severity. These include i) Relapsing Remitting MS (RR-MS), ii) Secondary Progressive MS (SP-MS) and iii) Primary Progressive MS (PP-MS). MS is more prevalent in women and accounts for more than two thirds of all MS sufferers. MS is considered to be a multifactorial disorder with both genetic and environmental components. The prevalence of MS is dependent on geographical localisation, with lower sunlight exposure linked to higher prevalence. Also, studies show an increased risk in close relatives, or in identical twins, indicating a significant genetic component to the disorder. There are a number of genes that may plausibly be involved in MS pathophysiology. These include myelin-related genes, such as the myelin basic protein (MBP), immune-related genes, such FC receptor and osteopontin, and heat shock proteins such as xb crystallin. These candidate genes have been implicated in a variety of ways but usually through immunological and/or genetic studies. One of the most consistent findings in recent years has been the association of disease with alterations in the specific major histocompatibility complex (MHC) localised to chromosome 6p21.3, and includes MHC I, II, III. Genome wide screens have permitted the identification of loci in the genome, which are associated with MS susceptibility. The number of genes involved in MS is unknown and several case-control association studies have been undertaken to reveal the involvement of potential candidate genes. In general terms, current research is aimed at determining allelic variation of candidate genes. Such genes have been implicated in MS because they reside within susceptible regions of the chromosome associated with MS or they have a plausible potential pathophysiological role in MS. Candidate loci investigated in this study, for association with MS susceptibility, include members of the nitric oxide synthase family of metabolic proteins (inducible NOS, iNOS/NOS2A and neuronal NOS, nNOS), methylenetetrahydrofolate reductase (MTHFR), catechol-O-methyl transferase (COMT), and vitamin D receptor (VDR). The MS population used in all studies consisted of over 100 MS cases and gender, age and ethnicity matched controls. In our study of inducible and neuronal NOS genes, PCR based assays were developed to amplify a region of both promoters that contained known microsatellite variation. Supporting phyisological data suggests that the neuroinflammatory aspects of MS are associated with aberrant NO production, which may be due to aberrant regulation of NOS activity. Specific amplified products were identified by fluorescent capillary electrophoresis and allele frequencies were statistically compared using chi-squared analysis. In the nNOS and iNOS study, no association was identified with allele frequency variation and MS susceptibility (nNOS: ?2=5.63, P=0.962; iNOS: ?2=3.4; P=0.082). Similarly, no differences in allele frequencies were observed for gender or clinical course for both markers (Pvalue greater than 0.05). In short, results from this study indicate that the NOS promoter variations studied do not play a significant role in determining susceptibility to MS in the tested population. The COMT and MTHFR genes are localised at 22q12-13 and 1p36.3 respectively, regions of the genome that have been found to be positively associated with MS susceptibility. In our research, we set out to examine the G158A change in the 4th exon of the COMT gene. This functional mutation leads to an amino acid change (valine to methionine) that is directly associated with changes in the activity of COMT. The MTHFR enzyme plays a role in folate metabolism, and can be implicated in the turnover of homocysteine. Previous investigations have shown that high levels of homocysteine are encountered in MS patients, where it is also linked to demyelination in the CNS. In our study the aim was to examine the C677T variation (alanine to valine amino acid change) in the exon 4 coding region of the MTHFR gene and the G158A variation in the COMT gene. Restriction fragment length polymorphism (RFLP) analysis and gel electrophoresis was used to identify specific alleles for both COMT and MTHFR. However, as with the NOS study, no specific association was identified between MS susceptibility and variation for either of the tested COMT or MTHFR (Pvalue greater than 0.05) variants. In a final genomic investigation of the MS population, three variations in the VDR gene were analysed for association with MS susceptibility and pathology. Using RFLP analysis, three VDR variants were investigated with genotypes detected using the Taq I, Apa I and Fok I restriction enzymes. In contrast to previous genotypic analyses, this study did show a positive association, specifically between the functional variation in exon 9 of the VDR gene and MS (Taq I, 2= 7.22, P= 0.0072). Interestingly, the Apa I variant of VDR was also found to be associated with MS ( 2=4.2, P=0.04). The Taq I and Apa I variants were also found to be in very strong and significant linkage disequilibrium (D'=0.96, Pvalue less than 0.0001) and their associations were more prominent with the progressive forms of MS (SP-MS and PP-MS). In addition to genotypic analysis of a clinical population, additional research was undertaken to identify novel targets for MS susceptibility studies. Global gene expression analysis was undertaken using comparative subtractive fluorescent microarray technology to examine differences in gene activity (expression) in age and sex matched MS plaque tissue and anatomically matched normal white matter (NWM). MS plaques were obtained post mortem from MS sufferers with no drug history in the last two months before death and matched anatomically to healthy white matter from donors with no previous neurological disorders. Target arrays consisted of 5000 cDNAs and analysis was conducted using the Affymetrix 428 scanner. In this way, 139 genes were shown to be differentially regulated in MS plaque tissue compared to NWM. Of these, 69 genes showed a common pattern of expression in the chronic active and acute plaque tissues investigated (Pvalue less than 0.0001, a=0.73); while 70 transcripts were uniquely differentially expressed ( 1.5-fold) in either acute or chronic active lesions. To validate the gene expression profile results, quantitative real time reverse transcriptase (RT) PCR (Q-PCR) analysis was performed. 12 genes were selected because they were shown to be differentially expressed by array analysis in this study, or because of their involvement in MS pathology. These included transferrin (TF), superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPX1), glutathione S-transferase pi (GSTP1), crystallin, alpha-B (CRYAB), phosphomannomutase 1 (PMM1), tubulin beta-5 (TBB5), inositol 1,4,5-trisphosphate 3-kinase B (ITPKB), calpain 1 (CAPNS1), osteopontin (SPP1 or OPN), as well as the signal transducer and activator of transcription 1 (STAT1) and protein inhibitor of activated STAT1 (PIAS1). Both absolute (copy number) and comparative differences in the relative levels of expression in MS lesions and NWM were determined for each gene. The results from this study revealed a significant correlation of real time PCR results with the microarray data, while a significant correlation was also found between comparative and absolute determinations of fold. As with the results of array analysis, a significant difference in gene expression patterning was identified between chronic active and acute plaque pathologies. For example, a up to 50-fold increase in SPP1 and ITPKB levels in acute plaques contrasted with the 5-fold or less increase in chronic active plaques (P less than 0.0.1, unpaired t-Test). Of particular note, gamma-amino butyric acid receptor ?2 (GABG2), integrin ?5 (ITGB5), complement component 4B (C4B), parathyroid hormone receptor 1 (PTHR1) were found up-regulated in MS and glial derived neurotropic factor ?2 (GDNFA2), insulin receptor (INSR), thyroid hormone receptor ZAKI4 (ZAKI4) were found down-regulated in MS. Data also revealed a decreased expression of the immune related genes STAT1 and PIAS1 in acute plaques. In conclusion, this research used both genomic analysis and technologies in gene expression to investigate both known and novel markers of MS pathology and susceptibility. The study developed tools that may be used for further investigation of clinical pathology in MS and have provided interesting initial expression data to further investigate the genes that play a role in MS development and progression.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Health Sciences
Full Text
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Wolfart, Senaide. "Programa Nossa Terra, Nossa Gente: festas, rádio e política (1982-2000)". Universidade Estadual do Oeste do Paraná, 2013. http://tede.unioeste.br:8080/tede/handle/tede/1686.
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Previous issue date: 2013-02-27This study approaches the narratives of lived experiences in the space of partying and traveling radio program Nossa Terra, Nossa Gente. The program was transmitted live on the mornings by Radio Difusora, being presented by broadcaster Manuel Ferreira Canabarro, the Gauchinho, who was also mainly responsible for organizing the parties in association with the communities that were done in the afternoon, after the live broadcast by radio program Nossa Terra, Nossa Gente. The event lasted from 1982 to 2000 and occurred in the municipality of Marechal Cândido Rondon, where is the Radio Difusora, apart from Mercedes, Nova Santa Rosa, Quatro Pontes, Toledo, Ouro Verde do Oeste, São José das Palmeiras, Entre Rios do Oeste, Pato Bragado, Santa Helena, Terra Roxa, Guaíra, and the districts of these cities. Therefore, we discuss the various views of the subjects present in the radio program and at the parties, like the participants, organizers and musicians. Noteworthy is the role performed by the Radio Difusora, acting as an agent, very present in the daily region where the parties and the program were held. Therefore, discuss some issues on broadcasting in the town of Marechal Cândido Rondon, and especially, the objectives of the creation and operation of the program Nossa Terra, Nossa Gente. Also discussed will be the LP produced by Radio Difusora with songs of singers who presented the program. Among the sources used to research beyond the narrative and the LP, makes use of features of the Frente Ampla de Notícias newspaper and O Presente
O presente estudo aborda as narrativas das experiências vividas nos espaços do programa radiofônico itinerante Nossa Terra, Nossa Gente e das festas realizadas após a sua transmissão. O programa era transmitido aos domingos de manhã, ao vivo, pela Rádio Difusora, apresentado pelo radialista Manuel Ferreira Canabarro, o Gauchinho, que era, também, o principal responsável pela organização das festas realizadas, em associação com as comunidades, nas tardes de domingo, após a transmissão ao vivo pela rádio. O evento perdurou de 1982 a 2000 e acontecia no município de Marechal Cândido Rondon, onde se situa a Rádio Difusora, além dos municípios de Mercedes, Nova Santa Rosa, Quatro Pontes, Toledo, Ouro Verde do Oeste, São José das Palmeiras, Entre Rios do Oeste, Pato Bragado, Santa Helena, Terra Roxa, Guaíra e nos distritos desses municípios. Abordam-se os diversos olhares dos sujeitos presentes no programa radiofônico e nas festas, dentre participantes, organizadores e músicos. Destaca-se o papel exercido pela Rádio Difusora no cotidiano da região onde aconteciam o programa e as festas. Abarcam-se algumas questões sobre a radiodifusão na cidade de Marechal Cândido Rondon e, principalmente, os objetivos da criação e a operação do programa Nossa Terra, Nossa Gente. Analisa-se, também, o LP produzido pela Rádio Difusora com músicas dos cantores que se apresentavam no programa. Dentre as fontes utilizadas para a pesquisa, além das narrativas e do LP, faz-se uso de reportagens do Frente Ampla de Notícias e do Jornal O Presente
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Aires, João Paulo Gill de Barros de Machado. ""Mostra a nossa voz"!" Programa de Pós-Graduação em Artes visuais da UFBA, 2011. http://www.repositorio.ufba.br/ri/handle/ri/9848.
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Esta dissertação é uma reflexão sobre a história de vida dos indivíduos que aproveitam o lixo como forma de subsistência: os catadores de materiais recicláveis. Foca em particular os catadores de lixo do município do Salvador, Bahia. Aborda a sociabilidade do trabalho e a prática da economia solidária. Discuti o problema da sustentabilidade na atividade econômica, a fragilidade das experiências empreendedoras bem como a observação da produção dos resíduos. Aborda conceitos da sociologia da arte e arte e sociedade no contexto contemporâneo, na dimensão crítica e reflexiva de Joseph Beuys. Cria poéticas visuais que causam impactos e suscitam o diálogo entre dois mundos: o mundo do consumo e o mundo do desperdício. A observação participativa é neste trabalho a base que dá origem a essa pesquisa. Com esta vivência tive a intenção de criar, através da arte, esse questionamento que da origem à reflexão sobre a temática, e, a partir da cooperação com os catadores, “Mostra a Nossa Voz” sobre um problema social. Compreende a importância do artista visual no mundo como agente social que desperte no público o interesse, a reflexão critica sobre os problemas sociais de ordem humanista.
Salvador
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Luís, Sílvia. "Nossa Senhora da Piedade - Piéta". Master's thesis, Instituto Politécnico de Tomar, 2012. http://hdl.handle.net/10400.26/5889.
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O trabalho que se apresenta centra-se no domínio da Conservação e Restauro do Património, no âmbito do estudo e conservação da Nossa Senhora da Piedade, propriedade da Irmandade de Nossa Senhora do Livramento de Angra do Heroísmo, Ilha Terceira.
O presente estudo está inserido no estágio de Conservação e Restauro de escultura em madeira policromada, sendo nele abordada a contextualização da obra na sua dimensão artística e histórica, os materiais e técnicas do suporte e camadas superficiais, o seu estado de conservação, uma metodologia para a posterior intervenção e por fim um estudo para o possível plano de manutenção do local de exposição.
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Ribeiro, Margarida Maria Queirós Magno Leitão. "Uma galáxia como a nossa". Master's thesis, Porto : [s. n.], 2004. http://hdl.handle.net/10216/64046.
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Ribeiro, Margarida Maria Queirós Magno Leitão. "Uma galáxia como a nossa". Dissertação, Porto : [s. n.], 2004. http://catalogo.up.pt/F?func=find-b&local_base=FCB01&find_code=SYS&request=000074123.
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OLIVEIRA, Milena Rodrigues de. "MANIFESTAÇÕES DA FÉ CATÓLICA: um estudo sobre as festas de Nossa Senhora dos Remédios, Nossa Senhora da Conceição e Nossa Senhora do Rosário em São Luís (1850- 1875)". Universidade Federal do Maranhão, 2016. http://tedebc.ufma.br:8080/jspui/handle/tede/1764.
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FAPEMA
This study researched the main religious festivals that took place in São Luís in the 1850 period to 1875, religious festivals encompassed three stages, the first was the Mass that took place within the Church, the second was the procession and the third involved party off, this study decided to study in more detail the second and third stage of the festival, among the parties have chosen three to specify in more detail on specific chapters, these were Our Lady of Remedios that was frequented by merchants, Our Lady of the Rosary I accepted slaves and Our Lady of the Conception who accepted free and brown. The period 1850-1875 was chosen by the availability of documentation and the greater control that the Catholic Church decided to carry on his devotees in the second half of the nineteenth century, used as appointments reference, which were documents regulating the administration of the brotherhoods, newspapers, collection laws and even pastoral letters, for a better foundation on the subject also left for a literature that has helped us to further deepen our object.
Este estudo pesquisou sobre as principais festas religiosas ocorridas em São Luís do Maranhão no período de 1850 a 1875, as festas religiosas englobavam três etapas, a primeira era a missa que acontecia dentro da Igreja, a segunda era a procissão e a terceira envolvia a festa de largo, esta pesquisa resolveu estudar de forma mais detalhada a segunda e a terceira etapa da festividade, dentre as festas escolhemos três para especificar com mais detalhes em capítulos específicos, estas foram Nossa Senhora dos Remédios que era frequentada por comerciantes, Nossa Senhora do Rosário que aceitava escravos e Nossa Senhora da Conceição que aceitava livres e mulatos. O período de 1850 a 1875 foi escolhido pela disponibilidade de documentação e pelo maior controle que a Igreja Católica resolveu exercer sobre seus devotos na segunda metade do século XIX, utilizamos como referência compromissos, que eram documentos que regulavam a administração das irmandades, jornais, coleção de leis e até cartas pastorais, para uma melhor fundamentação acerca do tema partimos também para uma pesquisa bibliográfica que nos ajudou a aprofundar ainda mais o nosso objeto.
Książki na temat "NOS2A"
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Fontan, José Coco. Nossa gente, nossa terra. [Vitória, Espírito Santo, Brazil: s.n., 1999.
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Júnior, Waldemiro Bley. Nossa gente, nossa história. Curitiba: Editora Protexto, 2002.
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Júnior, Waldemiro Bley. Nossa gente, nossa história. Curitiba: Editora Protexto, 2002.
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Matthiesen, Alcyr J. Araras: Nossa terra, nossa gente. Araras: Zurita Laboratório Farmacêutico, 1990.
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Coen, Edoardo. Cabreúva: Nossa cidade, nossa memória. Cabreúva: Prefeitura do Município de Cabreúva, 2000.
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Estrela, Edite. Sintra: Nossa terra, nossa gente. Lisboa: Notícias Editorial, 1997.
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Lima, Dante de. Mundo Novo: Nossa terra, nossa gente. Salvador-BA, Brasil: Contemp Editora, 1988.
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Magalhães, Fábio. Brasil brasileiro: Nossa terra, nossa gente. São Paulo: Centro Cultural Banco do Brasil, 2008.
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Nosa hyŏbŭihoepŏp sanghae: Nosa hyŏbŭihoe wa nosa kwanʼgye. Sŏul Tʻŭkpyŏlsi: Chungang Kyŏngjesa, 1988.
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Tur, Vicent. Nosa. Mallorca: Editorial Moll, 2001.
Znajdź pełny tekst źródłaCzęści książek na temat "NOS2A"
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Goldring, Christopher, Sylvie Reveneau i Jean-François Jeannin. "Transcriptional Regulation of the Macrophage NOS2 Gene". W Nitric Oxide in Transplant Rejection and Anti-Tumor Defense, 267–76. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5081-5_17.
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Benvenutti, Guilherme Renan. "RESGATANDO NOSSA HISTÓRIA". W AMPLAMENTE: EDUCAÇÃO NA CONTEMPORANEIDADE, 265–71. Amplamente Cursos e Formação Continuada, 2020. http://dx.doi.org/10.47538/ac-2020.03-25.
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Garcia, Solimar. "Começando nossa Conversa". W A Propaganda e a sua Relação com a Sustentabilidade, 11–20. Editora Blucher, 2019. http://dx.doi.org/10.5151/9788580393774-01.
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Dutra, Luiz Henrique de Araújo. "Nossa herança dualista". W Autômatos geniais: a mente como sistema emergente e perspectivista, 39–86. Editora UnB, 2018. http://dx.doi.org/10.7476/9788523013387.0003.
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"Front Matter". W Nossa and Nuestra América, i—iv. Purdue University Press, 2011. http://dx.doi.org/10.2307/j.ctt6wq2xg.1.
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"Appendix". W Nossa and Nuestra América, 211–18. Purdue University Press, 2011. http://dx.doi.org/10.2307/j.ctt6wq2xg.10.
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"Notes". W Nossa and Nuestra América, 219–40. Purdue University Press, 2011. http://dx.doi.org/10.2307/j.ctt6wq2xg.11.
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"Works Cited". W Nossa and Nuestra América, 241–52. Purdue University Press, 2011. http://dx.doi.org/10.2307/j.ctt6wq2xg.12.
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"Index". W Nossa and Nuestra América, 253–64. Purdue University Press, 2011. http://dx.doi.org/10.2307/j.ctt6wq2xg.13.
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"Back Matter". W Nossa and Nuestra América, 265–67. Purdue University Press, 2011. http://dx.doi.org/10.2307/j.ctt6wq2xg.14.
Pełny tekst źródłaStreszczenia konferencji na temat "NOS2A"
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Benbetka, Yacine, Nassima Djami i Aziza Fissah. "Study of the Association of Functional Polymorphisms Affecting the TLR2, TIRAP, TNF, IL1B, IL1RN, IL12B and NOS2A Genes with Susceptibility to Pulmonary Tuberculosis". W ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4602.
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Arrais, R. C. C., S. S. Saad, E. M. Caetano Junior i M. A. Santos. "Ileostomia Fantasma: Nossa Experiência". W 69a Congresso Brasileiro 27° Congresso Latinoamericano de Coloproctologia 2021. Thieme Revinter Publicações Ltda., 2021. http://dx.doi.org/10.1055/s-0041-1741920.
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José da Silva, edimar, i JOÃO JOSÉ BATISTA FILHO. "A importância do (re) conhecimento da nossa história e cultura, fonte da nossa ancestralidade". W II SEMINÁRIO INSTITUCIONAL ACADÊMICO-CIENTÍFICO DO Pibid/FBJ. Belo Jardim, Pernambuco: Even3, 2020. http://dx.doi.org/10.29327/seminariopibidfbj.137032.
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De Souza, Estéfane Carmo, Diego Do Carmo Silva i Roberto Almeida Bittencourt. "E se Nossa Oficina não Der Certo?" W Congresso sobre Tecnologias na Educação. Sociedade Brasileira de Computação - SBC, 2020. http://dx.doi.org/10.5753/ctrle.2020.11392.
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A inclusão do ensino de computação na educação básica é uma tema de interesse crescente no Brasil. Uma das formas de trabalhar conceitos de computação é através da Computação Criativa, abordagem que privilegia a criatividade e a colaboração. Este artigo apresenta um relato de experiência de uma oficina de Computação Criativa com uma turma de sexto ano do Ensino Fundamental II de uma escola estadual pública, apoiada pelo uso do ambiente Scratch e de um livro didático. A experiência permitiu identificar fatores que podem influenciar positiva ou negativamente na efetiva aprendizagem e no nível de motivação dos estudantes.
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Santos, Ially Silva, Antônio Roberto Martins Bunes, Bárbara Nascimento Santos, Bruno Silva Dos Santos i José Jairo Florentino Cordeiro Júnior. "EDUCAÇÃO AMBIENTAL EM NOSSA SENHORA DA GLÓRIA-SE". W I Congresso Nacional On-line de Conservação e Educação Ambiental. Revista Multidisciplinar de Educação e Meio Ambiente, 2021. http://dx.doi.org/10.51189/rema/1794.
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Introdução: A temática Educação Ambiental visa explicar a relação do homem com a natureza, à qual é um processo que busca promover orientação, conscientização e informação para o desenvolvimento de seres humanos ambientalmente ecológicos. Objetivo: O Projeto de Extensão Educação Ambiental em Ação buscou conhecer as principais causas dos problemas ambientais urbanos recorrentes em Nossa Senhora da Glória - SE e região. Material e métodos: Foi elaborado um questionário com 25 questões tratando-se dos principais problemas ambientais observados em Nossa Senhora da Glória - SE e região. Foi aplicado a partir do mês de setembro de 2020 e finalizado em janeiro de 2021, direcionado para estudantes da rede pública e privada de ensino situados na zona urbana e rural. 93 pessoas responderam ao questionário. Após a realização das atividades os dados gerados com a aplicação dos questionários foram processados para análise, na qual foi utilizada a estatística descritiva para possibilitar a interpretação dos mesmos. Resultados: São diversas as causas dos problemas ambientais, uma delas se refere ao descarte irregular do lixo, pois 46,2% dos participantes realizam o descarte em lugares onde acontecem a coleta de lixo, já nas áreas rurais acabam realizando o descarte de forma inapropriada e prejudicial para o meio ambiente. Além disso, 40,9% dos participantes relataram que não realizam a separação do lixo, o que é preocupante, pois o mesmo segue para lixões a céu aberto impedindo que ocorra a reciclagem. Do mesmo modo, 55% dos participantes não separam ou separam parcialmente o óleo de cozinha, podendo causar sérios danos ao meio ambiente. Observa-se que a principal problemática é o descarte final do lixo, bem como o processo de coleta em que não há separação dos tipos de lixo, tendo em vista, a importância de destinar o lixo ao local correto para minimizar o impacto do mesmo sobre o meio ambiente. Conclusão: Portanto, através do questionário analisou-se que os problemas ambientais são decorrentes das ações negligentes da sociedade.
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BANDEIRA, NáDIA SCHULTZ, TAíS STEFFENELLO GHISLENI i ELSBETH LéIA SPODE BECKER. "NOSSO CORPO É A NOSSA CASA: 21 HÁBITOS CONSCIENTES". W XXIV Simpósio de Ensino, Pesquisa e Extensão - SEPE. sepebr, 2020. http://dx.doi.org/10.48195/sepe2020-119.
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Arrais, R. C. C., S. M. Botequio Mella, E. M. Caetano Junior, S. S. Saad i M. A. Santos. "Endometriose Profunda Intestinal: Nossa Experiência nos Últimos 5 Anos". W 69a Congresso Brasileiro 27° Congresso Latinoamericano de Coloproctologia 2021. Thieme Revinter Publicações Ltda., 2021. http://dx.doi.org/10.1055/s-0041-1741826.
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Sevalho, Patrícia, Maria Raila Souza Carioca, Daiancre Anne Ribeiro Cabral i Rita de Cássia Eutrópio Mendonça Bezerra. "A PERSISTÊNCIA DA VIOLÊNCIA CONTRA A MULHER EM NOSSA SOCIEDADE". W III SIMPÓSIO NACIONAL DE PESQUISA DO DOUTORADO INTERINSTITUCIONAL EM EDUCAÇÃO-UERJ/UEA; II CICLO NACIONAL DE DEBATES INTERDISCIPLINARES CEST/UEA; III SEMINÁRIO EDUCA; SEMANA DA PEDAGOGIA; MOSTRA DA RESIDÊNCIA PEDAGÓGICA DE TEFÉ E PIBID-CEST-UEA. Tefé, Amazonas: Even3, 2020. http://dx.doi.org/10.29327/cicloeduca.228038.
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Rodrigues Velasque, Marcos. "PATRIMÔNIO CULTURAL IMATERIALCOMO MANTER NOSSA HISTÓRIA E A CULTURA VIVA". W 24º CIAED Congresso Internacional ABED de Educação a Distância. Associação Brasileira de Educação a Distância, 2018. http://dx.doi.org/10.17143/ciaed/xxivciaed.2018.7350.
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Feitosa, I., J. Bezerra L. Rodrigues i N. Rodrigues. "Levantamento de manifestações patologicas da Catedral Paróquia Nossa Senhora da Penha". W CONGRESO LATINO-AMERICANO DE PATOLOGÍA DE CONSTRUCCIÓN. ALCONPAT, 2021. http://dx.doi.org/10.4322/conpat2021.681.
Pełny tekst źródłaRaporty organizacyjne na temat "NOS2A"
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Beyer, Ross A., Terry Fong, Mark B. Allan, Jason Laura, Moses P. Milazzo, Robert G. Deen i Wayne Moses Burke. No to NOSA, Yes to Mainstream Licenses. Washington, D.C.: National Academies Press, grudzień 2018. http://dx.doi.org/10.17226/25217_28.
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Fioravanti, Reinaldo, José Yitani, Ana Haro González, Rodolfo Gomes Benevenuto, Rafael Ribeiro Silveira, Diego Camargo Botassio i Renato Alves Morato. Estruturação de Propostas de Investimento em Infraestrutura - Modelo de 5 Dimensões: Adaptação do "Five Case Model" para o Contexto Brasileiro. Banco Interamericano de Desenvolvimento, lipiec 2022. http://dx.doi.org/10.18235/0004359.
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Um dos maiores desafios para a economia brasileira é se consolidar em uma rota de prosperidade e bem-estar sustentável no médio e longo prazo. No entanto, superar a restriço orçamentária imposta pela pandemia e o histórico de baixa efetividade de investimentos na esfera pública no é trivial. A superaço desse desafio envolve no apenas a melhoria do gasto público, mas principalmente o aumento da atratividade do capital privado para nossa carteira de projetos de infraestrutura. Levantamentos recentes do Ministério da Economia realizados a partir dos diversos planos setoriais de infraestrutura indicam a necessidade de um choque de investimento da ordem de R$ 8,6 trilhes até 2050. A previso é que esse montante seja necessário para destravar o aumento da produtividade da nossa economia, além de garantir a universalizaço de serviços essenciais de infraestrutura para a populaço brasileira. Nesse sentido, o ferramental apresentado neste Guia oferece diretrizes para que os projetos de investimento em infraestrutura sejam feitos de maneira mais objetiva, transparente e sistemática, auxiliando o dirigente público na tomada de decises e na melhoria da qualidade dos gastos.
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Nico, Bravo. Relatório Final do Projecto de Investigação “Cartografia das Aprendizagens das freguesias de Torre de Coelheiros, Nossa Senhora de Machede e São Miguel de Machede”. Departamento de Pedagogia e Educação da Universidade de Évora, 2004. http://dx.doi.org/10.5935/ref.20160085.
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Nico, Bravo. Relatório Final do Projecto de Investigação “Cartografia das Aprendizagens das freguesias de Torre de Coelheiros, Nossa Senhora de Machede e São Miguel de Machede. Departamento de Pedagogia e Educação, 2004. http://dx.doi.org/10.5935/ref.20160152.
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Nieto Freire, Teresa, i Cristina Sánchez-Carretero. Foro Patrimonio e Sociedade Guía práctica para a análise dun sector clave na gobernanza do futuro 2019-2021. Redaktor Rebeca Blanco Rotea. Consello da Cultura Galega, lipiec 2021. http://dx.doi.org/10.17075/fpsgp.2021.
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Este documento resulta dun traballo iniciado pola Sección de Patrimonio e Bens Culturais do Consello da Cultura Galega (CCG) en outubro de 2018 e que tiña como obxectivo trazar as liñas xerais que guiarían o desenvolvemento dun foro baixo o título «Patrimonio e Sociedade». A intención era organizar este evento ao longo do ano 2020 e encamiñalo cara á reflexión e o establecemento dunhas directrices básicas arredor da xestión integral do patrimonio cultural na nosa comunidade autónoma. Finalmente, por causa do estado de alarma que vivimos no ano 2020, o foro adiouse 6 meses, prolongándose ata xuño de 2021 e rematando coa presentación deste documento. Nel plásmanse os motivos que levaron á súa realización, a estrutura, as temáticas, a calendarización e a súa metodoloxía. Inclúe tamén unha guía práctica resultante do traballo das mesas e outros materiais que se xeraron a partir das actividades desenvolvidas no transcurso do foro; en concreto, unha mesa política cos partidos que teñen representación no Parlamento de Galicia e unhas xornadas de presentación das conclusións.
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Cristina Fachinelli, Ana, Cíntia Paese Giacomelo, Bianca Libardi, Rafael de Lucena Perini, Suane de Atayde Moschen, Daniel Luis Notari, Suelen Bebber i in. OBSERVATÓRIO DE CIDADES - Relatório das Cidades do Corede Serra. UCS - Universidade de Caxias do Sul, luty 2023. http://dx.doi.org/10.18226/9786500628241.
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A utilização de dados para a tomada de decisão sempre foi, em grande medida, adotada pelas corporações empresariais e, nas últimas décadas, pelas gestões das cidades. A elaboração do Plano Plurianual e demais Planos das diversas dimensões do desenvolvimento contam com os dados das diversas plataformas de dados setoriais do governo estadual e federal. Com recursos da Consulta Popular e acompanhamento da Secretaria Estadual de Inovação, Ciência e Tecnologia foi possível disponibilizar aos gestores municipais uma única plataforma onde é possível verificar 68 indicadores que traduzem a fotografia atual dos ODS – Objetivos do Desenvolvimento Sustentável, dos indicadores que mostram o que é uma cidade inteligente (baseada na ISO 37.122) e os indicadores que mostram os capitais existentes nas cidades e que possibilitam a estruturação de redes que apoiam o desenvolvimento. Além dos indicadores oficiais, a plataforma disponibiliza dados de percepção dos cidadãos do COREDE SERRA. Foram mais de 1500 respondentes, que expuseram as suas percepções sobre aspectos de suas cidades nos três diferentes modelos: ODS, Cidades Inteligentes e Sistema de Capitais. Será possível olhar para cada cidade e compará-la com cidades vizinhas, com a região, com o estado do RS e com o país. Caso a cidade decida perseguir os indicadores da cidade mais bem colocada numa determinada variável, haverá possibilidade de criar estratégias para alcançar tais indicadores. Neste momento em que a UCS - Universidade de Caxias do Sul oferece o Observatório das Cidades aos gestores municipais, o COREDE SERRA sente-se honrado por ter possibilitado esta construção, no momento da escolha do projeto. Entende que os números em si são altamente relevantes para o planejamento do futuro que se deseja. Associar a análise dos dados a Pareceres do grupo de especialistas envolvidos com o Observatório demonstrará, de fato, a integração entre a UCS e o setor público buscando elevar, ainda mais, o compromisso com o desenvolvimento regional. O Observatório de Cidades agregará, no curto prazo, muitas possibilidades de apoio à construção de Planos de Desenvolvimento Locais estruturados e baseados no estado da arte. Nossa expectativa é que agentes públicos, instituições, cidadãos e o setor empresarial se apropriem das informações para que, em aliança, se busque qualificar as cidades para atendimento de uma sociedade em profunda transformação. Este relatório vem em complemento à Plataforma Web do Observatório de Cidades, trazendo uma versão resumida dos dados da região.