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Crane, Andrew, i Dirk Matten. "Incorporating the Corporation in Citizenship: A Response to Néron and Norman". Business Ethics Quarterly 18, nr 1 (styczeń 2008): 27–33. http://dx.doi.org/10.5840/beq20081812.
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This article presents a response to Néron and Norman’s contention that the language of citizenship is helpful in thinking about the political dimensions of corporate responsibilities. We argue that Néron and Norman’s main conclusions are valid but offer an extension of their analysis to incorporate extant streams of literature dealing with the political role of the corporation. We also propose that the perspective on citizenship adopted by Néron and Norman is rather narrow, and therefore provide some alternative ways in which corporations and citizenship might be brought together. We conclude by suggesting that, rather than simply applying the concept of citizenship to corporations, we now need to go further in exploring how corporations might play an active role in reconfiguring the whole notion of citizenship itself.
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Gillette, Robert. "Modelling Corporation Tax Revenue by John Creed and Norman Gemmell". National Tax Journal 65, nr 1 (marzec 2012): 235–39. http://dx.doi.org/10.17310/ntj.2012.1.09.
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Atzenbeck, Claus. "Interview with Norman Meyrowitz". ACM SIGWEB Newsletter, Autumn (marzec 2021): 1–5. http://dx.doi.org/10.1145/3460304.3460306.
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Norm Meyrowitz is currently an Adjunct Professor of the Practice of Computer Science at Brown University. He received an Sc.B. in Computer Science from Brown in 1981, and is recognized for his work on linking and multimedia technology for the Internet and for the evolution of Web development software. In the 1980s, Norm served as a Co-Director of Brown University's Institute for Research in Information and Scholarship, where he led the development of Intermedia, a hypermedia system that influenced both the creator of the Web and the creator of the Mosaic Web browser. In mid-1980s, he helped start two ACM conferences - OOPSLA (Object-Oriented Programming, Systems, and Languages) and Hypertext '87, which continue to this day. Following his work in academia, Norm worked for several years as the Director of System/User Software for pen/tablet pioneer GO Corporation before transitioning to his role as President of Product Development at Macromedia (later acquired by Adobe). At Macromedia, Norm oversaw a variety of Web development and multimedia products at Macromedia, including Shockwave, Dreamweaver, Flash, the latter of which had more than 4 billion downloads in its heyday in the 1990s and early 2000s.
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Speight, James G. "A review of: “CombustioD Measurement” Edited by Norman Chigier, Carnegie Mellon University, Pittsburgh Pennsylvania Hemisphere Publishing Corporation, Philadelphia, PA." Fuel Science and Technology International 10, nr 3 (styczeń 1992): 421–22. http://dx.doi.org/10.1080/08843759208915998.
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Theisen, Adam, Max Ungar, Bryan Sheridan i Bradley G. Illston. "More science with less: evaluation of a 3D-printed weather station". Atmospheric Measurement Techniques 13, nr 9 (4.09.2020): 4699–713. http://dx.doi.org/10.5194/amt-13-4699-2020.
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Abstract. A weather station built using 3D-printed parts and low-cost sensors, based on plans and guidance provided by the University Corporation for Atmospheric Research 3D-Printed Automatic Weather Station Initiative, was deployed alongside an Oklahoma Mesonet station to compare its performance against standard commercial sensors and determine the longevity and durability of the system. Temperature, relative humidity, atmospheric pressure, wind speed and direction, solar radiation, and precipitation measurements were collected over an 8-month field deployment in Norman, Oklahoma. Measurements were comparable to the commercial sensors except for wind direction, which proved to be problematic. Longevity and durability of the system varied, as some sensors and 3D-printed components failed during the deployment. Overall, results show that these low-cost sensors are comparable to the more expensive commercial counterparts and could serve as viable alternatives for researchers and educators with limited resources for short-term deployments. Long-term deployments are feasible with proper maintenance and regular replacement of sensors and 3D-printed components.
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Naylor, C. David. "Growing to Serve... A History of Victoria Hospital, London, Ontario. John R. Sullivan, Norman R. Ball, London, Victoria Hospital Corporation, 1985. Pp 163, illus., index, appendices". Scientia Canadensis: Canadian Journal of the History of Science, Technology and Medicine 11, nr 1 (1987): 47. http://dx.doi.org/10.7202/800248ar.
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Rahmawati, Rahmawati, i Soenarto Soenarto. "Use of the Delphy Technique: a case for the development of ecotourism in western Lombok". Jurnal Pendidikan Vokasi 9, nr 1 (5.03.2019): 92–104. http://dx.doi.org/10.21831/jpv.v9i1.23320.
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Delphi technique was developed in 1950 by researchers at the Rand Corporation led by Norman Delkey and Olaf Helmer and has since been used in hundreds of businesses forecasting in the public and private sectors. Delphi technique is a judgmental forecasting procedure for obtaining, exchanging, and developing an informed opinion about future events. Therefore, the Delphi technique is a systematic way to get a consensus of opinion among the experts who have related interests through a panel discussion. The objective of most Delphi is the reliable and creative exploration of ideas or the production of suitable information for decision making. The key features of the Delphi technique, namely: (1) systematic, (2) questionnaire, (3) expert judgment, (4) iteration process, and (5) feedback. Baseline characteristics of the Delphi technique (conventional) there are five, namely: (1) anonymity, (2) iteration, (3) controlled feedback, (4) statistical group response, and (5) expert consensus. While the characteristics of a policy Delphi also five, namely: (1) selective anonymity, (2) informed multiple advocacies, (3) polarized statistical response, (4) structured conflict, and (5) computer conferencing. Steps in the application of policy Delphi there are seven, namely: (1) issue specification, (2) selection advocates, (3) questionnaire design, (4) analysis of first-round results, (5) development of subsequent questionnaires, (6) organization of group meetings, and (7) preparation of final report.
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Connor, J. T. H. "John R. Sullivan and Norman R. Ball, Growing to Serve…A History of Victoria Hospital, London, Ontario.John R. Sullivan and Norman R. Ball, Growing to Serve…A History of Victoria Hospital, London, Ontario. London, Ontario: Victoria Hospital Corporation, 1985, 198 pp., $29.95." Canadian Bulletin of Medical History 3, nr 2 (październik 1986): 280–82. http://dx.doi.org/10.3138/cbmh.3.2.280.
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Kumjian, Matthew R., i Alexander V. Ryzhkov. "Polarimetric Signatures in Supercell Thunderstorms". Journal of Applied Meteorology and Climatology 47, nr 7 (1.07.2008): 1940–61. http://dx.doi.org/10.1175/2007jamc1874.1.
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Abstract Data from polarimetric radars offer remarkable insight into the microphysics of convective storms. Numerous tornadic and nontornadic supercell thunderstorms have been observed by the research polarimetric Weather Surveillance Radar-1988 Doppler (WSR-88D) in Norman, Oklahoma (KOUN); additional storm data come from the Enterprise Electronics Corporation “Sidpol” C-band polarimetric radar in Enterprise, Alabama, as well as the King City C-band polarimetric radar in Ontario, Canada. A number of distinctive polarimetric signatures are repeatedly found in each of these storms. The forward-flank downdraft (FFD) is characterized by a signature of hail observed as near-zero ZDR and high ZHH. In addition, a shallow region of very high ZDR is found consistently on the southern edge of the FFD, called the ZDR “arc.” The ZDR and KDP columns and midlevel “rings” of enhanced ZDR and depressed ρHV are usually observed in the vicinity of the main rotating updraft and in the rear-flank downdraft (RFD). Tornado touchdown is associated with a well-pronounced polarimetric debris signature. Similar polarimetric features in supercell thunderstorms have been reported in other studies. The data considered here are taken from both S- and C-band radars from different geographic locations and during different seasons. The consistent presence of these features may be indicative of fundamental processes intrinsic to supercell storms. Hypotheses on the origins, as well as microphysical and dynamical interpretations of these signatures, are presented. Implications about storm morphology for operational applications are suggested.
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Wilson, Benjamin. "The Consultants". Historical Studies in the Natural Sciences 45, nr 5 (1.11.2015): 758–804. http://dx.doi.org/10.1525/hsns.2015.45.5.758.
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After the laser was first demonstrated in 1960, many American defense officials hoped it would become a revolutionary new weapon. At the Institute for Defense Analyses (IDA), a nonprofit advisory corporation contracted to the Defense Department, experts studied the possibility of using lasers to defend against nuclear-tipped ballistic missiles. A few academic consultants for IDA (among them physicists Nicolaas Bloembergen, Charles Townes, Keith Brueckner, and Norman Kroll) began to think about how to generate laser pulses of enormous power and propagate them through the atmosphere. Along the way, in a mix of classified discussions and reports, and through a series of important publications in the open literature, the consultants laid the foundations of a new field: nonlinear optics. Nonlinear optics is the science of the interaction between matter and intense light, and it became a major branch of physics in the 1960s. The field’s history calls for deeper consideration of the ways in which powerful institutions and the production of knowledge were joined in the Cold War era. Though nonlinear optics was every bit “Cold War science,” the conventional and widely used concept of “patronage” seems inadequate for understanding the origins and development of the field. A product of neither government contracts nor innovations in technology alone, nonlinear optics was fashioned by a close-knit and elite community of experts straddling the classified and unclassified domains. The field took its peculiar shape and content within this unique social space—the social world of the Cold War defense consultant.
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Gurkov, Igor. "The growing anisotropy of the multinational corporation in the “new normal”". Journal of Organizational Change Management 32, nr 2 (8.04.2019): 194–207. http://dx.doi.org/10.1108/jocm-10-2017-0382.
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Purpose The purpose of this paper is to introduce a new research construct to depict more accurately organisational structure and the direction of organisational changes in large multinational corporations (MNCs). Design/methodology/approach The paper presents an overview of the existing literature on the phenomenon of anisotropy in natural sciences and the organisation of large corporations, and transforms an identified phenomenon into a research construct of organisational theory. Findings This paper demonstrates that anisotropy, that is, the differences in the speed and conductivity of the movement of capital (money), products (goods and services), ideas (knowledge) and talent (people) in different directions within the corporation (from the centre to the subsidiaries, from the subsidiaries to the corporate centre and between subsidiaries) is the normal state of the internal space of the MNC. Anisotropy is increasing with the on-going restructuring of the global economic order. This leads to the divergence of business units in MNCs into the core and the periphery. Research limitations/implications The paper outlines a series of promising research avenues in organisational studies. Originality/value The paper provides a novel treatment of the composition of MNCs.
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Milton, Mueller. "ICANN InC.: Accountability and Participation in the Governance of Critical Internet Resources". Korean Journal of Policy Studies 24, nr 2 (31.12.2009): 91–116. http://dx.doi.org/10.52372/kjps24205.
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This paper assesses the relationship between public participation and accountability in ICANN. It shows that ICANN tries to combine three distict organizational models as a result of its global governance responsibilities: it combines elements of a private corporation, a bottom-up standards body and a government regulatory agency. The paper shows that the private corporation model has come to dominate the other two; however, ICANN lacks the normal forms of accountability to which private corporations are subject. ICANN has responded to accountability concerns by creating new opportunities for public comment, review, and participation. This paper questions whether participation is an adequate substitute for accountability. It analyzes three distinct reforms in ICANN's history to show how participation can displace accountability rather than improve it.
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JPT staff, _. "Legends of Artificial Lift (July 2022)". Journal of Petroleum Technology 74, nr 07 (1.07.2022): 34–38. http://dx.doi.org/10.2118/0722-0034-jpt.
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Legends of Artificial Lift This year, the SPE Artificial Lift Conference and Exhibition–Americas will be held 23–25 August in Galveston, Texas, with the theme “Modern Artificial Lift–Adapting to a Changing Industry.” The event provides opportunities for technical professionals to gain insights into current trends and field experiences and explore innovative solutions. A special Legends of Artificial Lift Luncheon on 23 August will celebrate three individuals for their outstanding contributions to the technical knowledge in this field: Norman Hein Jr., Ken Nolen, and Gabor Takacs. Norman W. Hein Jr. Norman W. Hein Jr. has worked for 45 years in upstream production, his distinguished career spanning from research, development, and testing to ventures in production engineering, manufacturing, onshore and offshore project management, industry standardization, and the principles of artificial lift. Hein joined the industry in 1977 as a research scientist with Continental Oil Company, where he learned about oil and gas production materials, failures, fatigue, and offshore construction. He then worked for Conoco and later ConocoPhillips in various engineering positions. In 2010, he joined the sucker-rod division of Norris Production Solutions as director of research, development, engineering, and quality; later at CONSOL Energy he was promoted to chief technology professional and senior advisor. Currently, Hein is president and managing director of Oil and Gas Optimization Specialists Ltd., which he established in 2003. Kenneth B. (Ken) Nolen Kenneth B. (Ken) Nolen for 62 years has been a key contributor to what he calls “the art and science of artificial lift.” “My college degree in mechanical engineering was largely devoted to science,” he explains, “and that’s a branch of knowledge dealing with the physical world of facts and principles. Art, on the other hand, uses science to create new technology and products—in my field, that is to enhance artificial lift.” His career in optimizing this art and science began after graduating from Texas A&M and serving his country in the US Air Force for a 3-year tour. Nolen joined Shell Oil Company as a production engineer before teaming up with Dr. Sam G. Gibbs to become co-founderand vice president of Nabla Corporation in Midland, Texas—a technical service company that specialized in artificial-lift diagnosis, optimization, design, training on pumping wells, and manufacturing pumpoff controllers and fluid-level sounders. “It was at Nabla that I pursued my long-held passion for optimizing production from artificially lifted wells.” Gabor Takacs Gabor Takacs joins the Legends of Artificial Lift as an internationally recognized consultant with more than 35 years of consulting and teaching experience in the fields of production engineering, with a concentration in artificial lift. “The great honor of being nominated is an absolutely thrilling sensation for me,” he said. “It gives me a special satisfaction to be the first foreigner to join those wonderful people whom I have been privileged to meet and cooperate with during my career.” Takacs is a professor emeritus at the University of Miskolc, Hungary, where he led the petroleum engineering department from 1995 to 2012.
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Jaber Hashim, Salwan, Sergey A. Orekhov i Talib Al-Hamdawee Alaa Ammar. "Impact Analysis of Strategic Cost Management on Business Quality Modern Corporation". Journal of Social Sciences Research, Special Issue 5 (15.12.2018): 519–21. http://dx.doi.org/10.32861/jssr.spi5.519.521.
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The aim of research was to study Impact Analysis of Strategic Cost Management on Business Quality Modern Corporation. This research was descriptive and to analyze this research we used an independent T test. Results show that There was not a significant difference in the scores for Cost Management based (M=36.6, SD=1.51) and normal (M=39.0, SD=3.51) conditions; t (8) =-1.39, p = 0.201. These results suggest that Cost Management does not have an effect on Business Quality. Specifically, our results suggest that Corporations that use cost management do not necessarily have higher business quality.
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Barra Salazar, Ana M., i Yanina L. Muñoz Silva. "Estudio del gobierno corporativo de una sociedad anónima abierta: Caso aplicado a una empresa del sector Retail". Horizontes Empresariales 15, nr 1 (14.12.2016): 33–48. http://dx.doi.org/10.22320/hem.v15i1.2636.
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A partir de la promulgación de la Ley Nº 19.705, se da a conocer en nuestro país un nuevo concepto los llamados “gobiernos corporativos”. Así, este artículo tiene por objeto analizar el gobierno corporativo de una empresa del sector retail, caso aplicado a Ripley Corp., basándose en la literatura reciente, las leyes publicadas por el Gobierno de Chile, y las Normas Generales, dictadas por la Superintendencia de Valores y Seguros, se defi nieron criterios de evaluación del gobierno corporativo, resultados que arrojaron que la sociedad en estudio cumple casi a cabalidad dichos criterios.
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Zaniz, Letícia, Marilei Kroetz, Dinorá Baldo De Faveri, Ilda Valentim i Lara Fabiana Dallabona. "Evidenciação de riscos corporativos: uma análise nas empresas que mais negociaram ações na BM&F Bovespa no último quadrimestre de 2012". CONTRIBUCIONES A LAS CIENCIAS SOCIALES 16, nr 2 (22.03.2023): 874–91. http://dx.doi.org/10.55905/revconv.16n.2-026.
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O Mercado de Capitais brasileiro tem apresentado constante evolução em relação aos regulamentos e normas para a divulgação e evidenciação de riscos, bem como em relação à normatização e regulamentação para atender às boas práticas de Governança Corporativa, procurando fortalecer o gerenciamento e redução dos riscos. As empresas, para fazer a abertura de capital e negociarem ativos na Bolsa de Valores brasileira, necessitam fazer um registro junto à CVM – Comissão de Valores Mobiliários. A partir da aprovação desse registro, passam a ser obrigadas a atender as exigências de Governança Corporativa e de emissão de relatórios, conforme as normativas da CVM. Uma dessas normativas refere-se à Evidenciação de Riscos Corporativos, isto é, a Instrução Normativa da CVM nº 480. Este trabalho abordará a obrigação expressa na Instrução Normativa da CVM n° 480, tem por objetivo avaliar o grau de evidenciação de riscos corporativos de acordo com os níveis de Governança Corporativa, com o intuito de verificar se as empresas que mais negociam ações na Bolsa de Valores são escolhidas pela evidenciação de riscos. Para isso, utilizou-se de pesquisa descritiva e documental, de abordagem predominantemente qualitativa, para verificar os riscos corporativos evidenciados nas empresas que mais negociam ações na BM&F Bovespa. A amostra escolhida é não-aleatória e comporta as empresas listadas que se enquadram nos 80% de participação no IBOVESPA, carteira de setembro a dezembro de 2012, num total de 33 empresas. Das empresas selecionadas foram analisados os relatórios Risco de Mercado e Fatores de Risco do ‘Formulário de Referência’. Para demonstrar a evidenciação de risco, utilizou-se de pontuação de números inteiros, indicando ‘0’ para empresas que não mencionaram risco, ‘1’ para as empresas que mencionaram e ‘2’ para empresas que mencionaram e detalharam seus riscos corporativos. Os riscos foram categorizados de acordo com a Instrução Normativa nº480/09, sejam os quais: riscos relacionados à companhia, a seu controlador, a seus acionistas, a suas controladas e coligadas, a seus fornecedores, a seus clientes, aos setores da economia nos quais o emissor atue, à regulação dos setores em que o emissor atue. Pode-se concluir que o nível de evidenciação dos riscos foi insatisfatório em relação ao nível das empresas pesquisadas. A média de Evidenciação dos Riscos Corporativos dor Nível de Governança Corporativa foi de 54,40% no Novo Mercado, 45,77% no Nível 1, 44% no Nível 2 e 45,03% no Nível Tradicional. Ou seja, as empresas que mais negociam ações na BM&F Bovespa evidenciam entre 44% à 55% de Risco Corporativos.
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SAKO, Arjola. "A Model to Analyze the Financial Decision-Making of a Corporation Case Study KESH SHA". Economicus 19, nr 1 (2020): 79–97. http://dx.doi.org/10.58944/wgot3088.
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In order for corporations to operate effectively, it is necessary to emphasize the importance of financial decision-making in the stability of corporate governance. This paper is based on addressing two main issues. First, focusing on the key decisions of financial executives whose work should focus on maximizing corporate value or minimizing the cost of capital. Second, deepening the impact of the auditor’s characteristics on the performance of the corporate governance so that the audit creates added value for the entity. It aims to give a fresh perspective of the treatment of financial decision-making in corporations, arguing every step through the empirical analysis of the DuPont model where we rely to compare the performance over the years under review of the KESH sh.a (Albanian Electro-Energetic Corporation). The difference between the ordinary and the extraordinary is made by practice and financial decision-making is a topic that is both beautiful to deal with and difficult to analyze in information. We are all witnesses of the economic situation of our country. On the one hand we have a transition economy that is growing at a normal pace and on the other hand we have a community whose business is already trying to move to a consolidated stage becoming more competitive. Only in this way can corporations in Albania survive the demanding conditions of the global economy.
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Vaudo, Liliana. "Normas de Buen Gobierno Corporativo". VISUAL REVIEW. International Visual Culture Review / Revista Internacional de Cultura Visual 9, Monográfico (20.11.2022): 1–14. http://dx.doi.org/10.37467/revvisual.v9.3770.
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El tema investigado se enfoca en la evaluación de los mecanismos normativos de derecho blando y normas de cumplimiento destinados a garantizar la seguridad, la confianza empresarial y la prevención de violaciones del derecho positivo, contrarrestar sus efectos, proteger la reputación organizacional. Mediante una revisión documental de textos y normas desarrolladas por el ordenamiento jurídico venezolano, se obtiene como resultado, que además de contar con la regulación, es indispensable la efectiva implementación en la práctica de ambas exigencias normativas; sólo así se puede lograr la elevación de los estándares de operatividad, la calidad, la transparencia y la buena imagen corporativa.
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Grove, Hugh, Maclyn Clouse i Tracy Xu. "COVID reflections on corporate governance". Corporate Governance and Sustainability Review 5, nr 1, Special Issue (2021): 94–106. http://dx.doi.org/10.22495/cgsrv5i1sip1.
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The COVID-19 global pandemic has created unique and far-reaching impacts on corporations. Given the essential oversight role of boards of directors, it becomes critical for them to develop strategies as their companies respond to the challenges and risks under these unprecedented circumstances. This paper applies corporate governance principles and action plans for boards to help their companies survive this crisis and build sound business prospects both in the short run and long run. For immediate company survival, this paper encourages boards of directors to focus on short-term liquidity and employ five principles for COVID cash management as proposed in Gifford (2020), including detailed forecasting, setting spending priorities, initiating early communication, shortening reporting cycles, and planning for low cashpoints. Since liquidity does not equate to solvency for company survival, boards of directors also need to focus on long-term solvency by monitoring the new normal of business strategies, including the high likelihood of insolvency among small businesses and mixed solvency situations among large corporation. In addition, this paper identifies the key opportunities for the boards of directors to exploit and strengthen corporate governance during this pandemic period, including advocating a COVID disaster recovery plan with best practices, developing an emergency response checklist, establishing efficient disaster responses, and bolstering monitoring mechanisms for employees, operations, finances, customers, and supply chains (Butcher, 2020). The major sections of this paper are current COVID reflections, a case study of the Hertz Corporation, future COVID reflections, business strategies for the new normal, COVID cash management principles, COVID threats to corporate governance, COVID opportunities for corporate governance, and conclusions
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Kristina, Michelle. "Tipologi Penindakan Kejahatan Korporasi Dalam Korupsi Dana Bantuan Pandemi Covid-19". JURNAL YUSTIKA: MEDIA HUKUM DAN KEADILAN 24, nr 01 (24.09.2021): 1–13. http://dx.doi.org/10.24123/yustika.v24i01.4610.
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The development of human life nowadays cannot be separated from various aspects such as economy, politics, and technology, including the impact of the coronavirus outbreak (Covid-19 or SARS-CoV-2) which emerged at the end of 2019. Responding to this Covid-19 pandemic outbreak In Indonesia, the government has issued various policies as measures to prevent and handle the spread of Covid-19. One of these policies is to limit community activities. These restrictions have implications for the fulfilment of the economic needs of the affected communities. Responding to the urgency of this community's economic situation, the government held a social assistance program as a measure to ease the community's economic burden. However, the procurement of the program was used as a chance for corruption involving the Ministry of Social Affairs and corporations as the winning bidders. This study uses a qualitative methodology with a normative juridical approach and literature. The approach is carried out by conducting a juridical analysis based on a case approach. The results of the study show that the corporations involved cannot be separated from corporate responsibility. However, the criminal liability process against the corporation is deemed not to reflect justice for the current situation of Indonesia is experiencing. The crime was not carried out in a normal situation but in a situation when Indonesia was trying hard to overcome the urgent situation, the Covid-19 pandemic. Corporate crimes committed by taking advantage of the pandemic situation are deemed necessary to prioritize special action or the weight of criminal acts committed by corporations. The weighting of criminal sanction is the right step as a law enforcement process for corporate crimes during the pandemic.
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Volkodavova, Elena V., i Vasily V. Zhalnin. "Property and non-property risks in the Russian corporate governance system". Izvestiya of Saratov University. Economics. Management. Law 23, nr 3 (22.08.2023): 261–68. http://dx.doi.org/10.18500/1994-2540-2023-23-3-261-268.
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Introduction. Corporations today are the basis of any state’s economy, and within the framework of corporate governance, key strategic decisions are made that determine the fate of corporations. Accordingly, the problem of corporate governance risk management is one of the key economic problems, as it affects the interests of not only the participants of corporate relations, but also a huge number of economic agents. Theoretical analysis. The article presents the views of Russian scientists on the characteristics and classification of corporate governance risks, defines the property and non-property risks of corporate governance, considers the causes of their occurrence, as well as the mechanisms of influence on the corporation, its participants, creditors, public law entities. Also, a distinction is made between the objectively existing normal business risk and the predominantly subjective risks of corporate governance. Empirical analysis. Based on statistical data on bringing controlling persons to subsidiary liability, it is shown that the number of bankruptcies of Russian companies due to the manifestation of corporate governance risks is steadily growing. Results. The author’s typology of corporate governance risks, characterized by their relationship and interdependence is developed. Property and non-property risks of corporate governance are identified, the impact of which on the activities of Russian corporations is currently the most significant. Among them are those to which it is possible to adapt in the modern conditions of doing business. It is concluded that in the process of managing corporate risks based on the use of corporate law institutions existing in Russia and their combinations, it is impossible to nullify completely the occurrence and manifestation of the risks in question. Nevertheless, to ensure the necessary mutual control of the corporate relations subjects, limiting their ability to act in bad faith and unreasonably to the detriment of the company, is quite an achievable task.
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Araújo, Davi Jônatas Cunha, Renata Paes de Barros Câmara i Sheila Alice Gajadhar Araújo. "PERCEPÇÃO DA SUSTENTABILIDADE CORPORATIVA A PARTIR DE PRÁTICAS DIVULGADAS PELA GOVERNANÇA DE ESTATAIS". Revista Brasileira de Contabilidade e Gestão 12, nr 22 (23.06.2023): 066–91. http://dx.doi.org/10.5965/2764747112222023066.
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Objetivo: Investigar a percepção acerca da sustentabilidade corporativa por meio de práticas divulgadas pela governança de estatais federais de controle direto da União. Método(s): Pesquisa de natureza exploratória, com abordagem qualitativa e análise de relatórios corporativos. A análise de conteúdo ocorreu por meio do levantamento do compliance entre os relatórios de gestão das estatais ao framework da Global Reporting Initiative, via atendimento das diretrizes econômicas, ambientais e sociais recomendadas pelo órgão normativo. Resultados: Sustentabilidade corporativa é percebida como execução de normas e práticas de redução de custos pela governança. A governança das empresas públicas e das sociedades de economia mista não apresentaram percepção adequada acerca da sustentabilidade corporativa como práticas voluntárias, pois apenas atenderam às exigências decorrentes de eventuais fiscalizações. Para a governança das estatais, apresentar que as diretrizes do pilar econômico, ambiental e social estavam sendo cumpridas foi uma forma de se apresentarem mais eficientes. As diretrizes ambientais foram as menos cumpridas, apesar de muitas das estatais desempenharem o uso racional da água, consumo eficiente da energia, gerenciamento de resíduos e a coleta seletiva solidária. Contribuições: As governanças das estatais também não se apresentaram socialmente responsáveis, apesar de seus índices sociais apresentarem melhores desempenhos do que os ambientais. As estatais resumiram o pilar social ao oferecimento de treinamentos para seus funcionários, e divulgaram o atendimento de diretrizes recomendadas nos pilares econômico, ambiental e social como respostas a isomorfismo e como ferramenta de legitimidade.
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Rakangthong, Neeranat K., Yuttachai Hareebin, Kitikorn Dowpiset, Jaturon Jutidharabongse i Somnuk Aujirapongpan. "Exploring Managers' Skills Affecting Dynamic-Innovative Capabilities and Performance in New Normal Era". HighTech and Innovation Journal 4, nr 1 (1.03.2023): 37–54. http://dx.doi.org/10.28991/hij-2023-04-01-03.
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The human resources department, as a dynamic mechanism in the hotel business, is a supporter and a manager who manages the corporation to grow by planning, supervising, and assuring the expected performance leads to desirable outcomes. The situation of spread of the COVID-19 virus has resulted in businesses and labor departments having to adapt to survive by upgrading existing knowledge and adding new skills. Therefore, this research aims to describe components and models of necessary skills development for performance affecting dynamic capabilities and performance in a new normal era for human resources managers of five-star hotels in Phuket Province, which are crucial components in an increased corporation’s sustainability and performance in terms of personnel efficiency, assets, funds, and information. This research is quantitative, and research data was collected from a total of 384 human resource managers of five-star hotels. There was a mutual discussion of factor analysis and structural equation results with three human resources managers who have been successful for not less than seven years in their work. The components consisted of systematic consideration through the following causes: necessary skills; professional skills, work skills, and emotional skills, mediator variables; dynamic capabilities, and organizational performance. This research also discussed five guidelines for developing the necessary skills for performance. As various factors have affected the performance in the new normal era, the human resources executives of five-star hotels in Phuket province should apply them and consider them together with their business plans for setting the strategic plan of organizational management, management, administrative, and human resources development. Doi: 10.28991/HIJ-2023-04-01-03 Full Text: PDF
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Prevall, Ainota, i Karla Saraí Basurto-Gutiérrez. "Nivel de conocimiento financiero y desempeño laboral de directivos del corporativo adventista en Cuba". REEJ | Revista Estudios Empresariales y Jurídicos 1, nr 2 (30.05.2024): 1–10. http://dx.doi.org/10.37354/reej.2024.2.1.001.
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El objetivo del estudio fue conocer si existe una correlación significativa entre la alfabetización financiera necesaria para las tareas administrativas diarias y los niveles de rendimiento de los administradores dentro de la red corporativa adventista en Cuba. Esta investigación fue no experimental, cuantitativo, transversal y correlacional. Se utilizó un muestreo estratificado, incorporando a 123 directores de la red corporativa adventista en Cuba, de una población total de 242. El coeficiente alfa de Cronbach de 0.721 para el instrumento de alfabetización financiera de 15 ítems, y 0.870 para el instrumento de rendimiento laboral de 19 ítems, ambos considerados aceptables para este estudio. Se aplicó la prueba de rango correlacional de Spearman debido a la distribución no normal de los datos. Se encontró un coeficiente de correlación de Spearman (r) de .311 y un nivel de significancia (p) de .001. Dado este nivel de significancia (p < .05), se rechazó la hipótesis nula que sugería que no había relación entre las variables, apoyando la hipótesis alternativa de una correlación positiva de fuerza media. Los hallazgos sugieren que mejorar la alfabetización financiera necesaria para las tareas diarias, se correlaciona con un mejor rendimiento entre los administradores corporativos adventistas en Cuba que participaron en este estudio.
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Novakovich Gübelin, Marjorie, i Luis Mauricio Peralta Herrera. "Estado Actual de los Gobiernos Corporativos después de la Primera Aplicación de la Norma de Carácter General N° 341 de la SVS". Revista summa de arithmetica, nr 4 (31.12.2014): 41–54. http://dx.doi.org/10.11565/sda.v1i4.39.
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El Gobierno Corporativo (GC) es el conjunto de instancias y prácticas de la empresa en el proceso de toma de decisiones que contribuyen a la creación de valor a lo largo del tiempo, en un marco de transparencia y responsabilidad organizacional hacia las partes interesadas de la Empresa. Un buen GC debe incorporar y desarrollar permanentemente prácticas de incentivos y respeto a los derechos de los accionistas y a los grupos de interés que participan directa o indirectamente en la Empresa, a objeto de obtener beneficios conjuntos de ésta. La presencia de numerosos grupos económicos en Chile, de origen nacional y extranjeros, sumada a la alta concentración de propiedad de éstos, generó que los organismos fiscalizadores nacionales, como lo es la SVS, emitiera la Norma de Carácter General (NCG) N°341. Ello en consideración a la importancia que reviste para el mercado de valores que las sociedades anónimas abiertas revelen sus políticas y prácticas de gobiernos corporativos, de forma que los inversionistas tengan suficiente información respecto a ello.
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Lopo Martinez, Antonio. "Are IFRS Standards a Good Starting Point for a Corporate Tax Base? Tax Principles for a CCCTB". Revista Electrónica de Direito 20, nr 3 (2019): 113–37. http://dx.doi.org/10.24840/2182-9845_2019-0003_0006.
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This article discusses whether IAS/IFRS should be used as a starting point in the context of the Common Corporate Tax Base in the European Union. Non-European countries may also have an interest in the analysis on the use of IFRS to compute the corporate tax base, as well. After a background discussion on the application of IAS/IFRS as the start point for a tax base, some principles of tax bases are analyzed. Additionally, the disadvantages and advantages of using IAS/IFRS as the start point are presented. In the end, the creation of an independent tax accounting framework is recommended, which should have as the primary purpose taxation, and taxpayers and governments as the users of the information. In this new arena, the IAS/IFRS should be a valuable toolbox of concepts that can be adjusted for a tax perspective.
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Cabral de Vasconcellos, Patrícia Mara. "RESPONSABILIDADE SOCIAL E DEFESA DOS DIREITOS HUMANOS: O DEBATE SOBRE A ATUAÇÃO DAS EMPRESAS TRANSNACIONAIS". Revista Direitos Humanos e Democracia 8, nr 15 (6.08.2020): 41–59. http://dx.doi.org/10.21527/2317-5389.2020.15.41-59.
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O artigo analisa como a atuação das empresas transnacionais é questionada nas organizações internacionais, desde a década de 90 e, em especial, de que maneira, a partir da Resolução 26/9 de 2014 da Organização das Nações Unidas, tem-se buscado um tratado vinculante para responsabilizá-las nos casos de violações dos direitos humanos. Assim, inicialmente, a discussão demarca conceitos como a responsabilidade social corporativa, na expectativa social de uma conduta ética voluntária por parte das corporações. No entanto, com a recorrência da violação de direitos, o debate passou a incorporar a defesa dos direitos humanos e a reivindicação de normas internacionais de responsabilização. Para a análise, a metodologia constitui-se de pesquisa bibliográfica, documental e estudo de caso. Conclui-se que as diretrizes da ONU sobre a temática inserem-se em um sistema internacional assimétrico, de governos nacionais fragilizados. Apesar das transformações no debate, as diretrizes são insuficientes para frear a impunidade e converter a fragilidade jurídica da população frente ao poder corporativo.
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Zavala Ortiz de la Torre, Iñigo. "Las «benefit corporations» norteamericanas". Deusto Estudios Cooperativos, nr 3 (10.03.2021): 75–105. http://dx.doi.org/10.18543/dec-3-2013pp75-105.
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La Benefit Corporation es la nueva forma de empresa social surgida en el panorama legislativo norteamericano. Sobre la base de una estructura de sociedad mercantil capitalista, se pretende poder obtener resultados en beneficio del interés general. Este tipo social, trata de aunar los legítimos intereses financieros de los accionistas, con los de los otros stakeholders de la compañía. Para ello los administradores deberán aplicarse en la obtención de beneficios, pero a través del ejercicio de una actividad empresarial que, en su conjunto, tenga un impacto positivo en la sociedad y en el medio ambiente. Este impacto positivo, deberá poder ser, a su vez, objeto de evaluación a través de su contraste con normas estandarizadas, ideadas y aprobadas por terceros.
Recibido: 10 junio 2013Aceptado: 30 julio 2013
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Martins, Mary Anne Fontenele, Wildenildo Oliveira Dos Santos, Rodrigo Lino De Brito i Gustavo de Freitas Alves. "Política de gestão de riscos corporativos: o caso de uma agência reguladora da saúde". Revista do Serviço Público 69, nr 1 (29.03.2018): 7–32. http://dx.doi.org/10.21874/rsp.v69i1.3159.
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Estudo qualitativo e descritivo-exploratório que objetiva relatar a experiência da elaboração da Política de Gestão de Riscos Corporativos da Agência Nacional de Vigilância Sanitária (Anvisa), no período de 01 de novembro de 2016 a 31 de maio de 2017, como ferramenta estratégica de governança corporativa. A fundamentação teórica envolveu a ISO 31000, COSO ERM e normas de referências em gestão de riscos. Por meio da técnica de triangulação, utilizando a pesquisa documental, a pesquisa-ação e a de levantamento, verificou-se que a política foi desenvolvida em cinco grandes etapas inter-relacionadas: 1) sensibilização da alta liderança, 2) desenvolvimento de competências e benchmarking, 3) consulta interna, 4) comunicação e disseminação interna e 5) discussão aprovação da política pela diretoria colegiada. Conclui-se que a experiência da agência foi bastante satisfatória, uma vez que superou as recomendações dos órgãos de controle. Quando há uma política amplamente discutida, que busca potencializar o alcance da missão institucional e fortalecer o modelo de governança, essa experiência pode ser replicada por outros órgãos reguladores, observando as suas devidas especificidades.
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Oliveira, Mónica, Marisa Roriz Ferreira i Vanda Lima. "Responsabilidade social corporativa: conceito, instrumentos de gestão e normas". Revista Brasileira de Administração Científica 6, nr 2 (4.11.2015): 161–72. http://dx.doi.org/10.6008/spc2179-684x.2015.002.0011.
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Este trabalho tem como objetivo apresentar uma caracterização do conceito de responsabilidade social corporativa. Para tal o conceito é discutido num espectro mais teórico e são apresentados os instrumentos de gestão, nomeadamente códigos de ética e relatórios de sustentabilidade. Seguindo uma atitude mais pragmática, as organizações têm usado como ferramentas de apoio que permitem sistematizar a sua atuação e o relacionamento com a sociedade diversos normativos, que são apresentados e discutidos, sublinhando a importância da utilização dos mesmos. A relação de uma organização com os seus stakeholders constitui, hoje, um dos maiores reptos de uma gestão ajustada e atenta a uma conjuntura cada vez mais competitiva.
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McGinness, Kathleen E., Emily K. Waters, Ryan M. Genga, Karen A. Olson, Jennifer A. Nelson, Jeffrey C. Kurz i Robert G. Schaub. "TFPI Antagonist Aptamer ARC19499 Is a Procoagulant In Vitro and In Vivo." Blood 116, nr 21 (19.11.2010): 1134. http://dx.doi.org/10.1182/blood.v116.21.1134.1134.
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Abstract Abstract 1134 Hemophilia is a bleeding disorder that results from deficiencies in coagulation factor VIII (FVIII; hemophilia A) or factor IX (FIX; hemophilia B), primarily impacting the intrinsic coagulation pathway. The extrinsic coagulation pathway remains intact in hemophiliacs and is negatively regulated by tissue factor pathway inhibitor (TFPI). The primary role of TFPI is regulation of the FVIIa:tissue factor complex through inhibition of FVIIa and FXa. Inhibition of TFPI may provide an effective treatment for hemophilia by allowing sufficient thrombin generation via the extrinsic coagulation pathway to bypass the defect in clot propagation caused by deficiency of FVIII or FIX. ARC19499 is an aptamer that is a potent, specific inhibitor of TFPI. We have employed a variety of in vitro and in vivo methods to demonstrate that ARC19499 mediates a procoagulant effect in hemophilic plasma and in a model of hemophilia A in non-human primates (NHP). Plasma-based experiments that measure thrombin generation over time demonstrate that ARC19499 mediates a procoagulant response in both hemophilia A and hemophilia B plasma, restoring thrombin generation to near normal levels at 10 – 100 nM aptamer. Experiments in TFPI-depleted plasma and in vitro binding experiments demonstrate that this procoagulant effect is dependent on the specific interaction between ARC19499 and TFPI. ARC19499 restores thrombin generation to a level that is equivalent to or better than 14% FVIII replacement at a concentration of 30 nM in hemophilia A plasma and has an additive effect on thrombin generation when used in combination with FVIII. In a NHP model of hemophilia, cynomolgus monkeys acquire a hemophilia A-like state following administration of an anti-FVIII antibody as measured by ex vivo thromboelastography (TEG). TEG coagulation parameters are corrected following administration of ARC19499. In addition, antibody-mediated FVIII depletion moderately prolongs saphenous-vein bleeding time. ARC19499 corrects bleeding times to normal. These experiments demonstrate that the anti-TFPI aptamer ARC19499 mediates a procoagulant hemostatic effect both in vitro and in vivo in hemophilia model systems that is dependent on specific interaction between the aptamer and TFPI. ARC19499 may provide an effective alternative to replacement factors and bypassing agents for the treatment of hemophilia. Additionally, aptamer therapeutics have the advantage of subcutaneous bioavailability which provides an opportunity for improved treatment regimens in hemophilia. Disclosures: McGinness: Archemix Corporation: Employment. Waters:Archemix Corporation: Employment. Genga:Archemix Corporation: Employment. Olson:Archemix Corporation: Employment. Nelson:Archemix Corporation: Employment. Kurz:Archemix Corporation: Employment. Schaub:Archemix Corporation: Employment.
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Baerlocher, Gabriela M., Katia Bassett, Dirk de Beer, Laurence Elias, Ning F. Go i Alexander Roeth. "Leukemic T-PLL Cells Exhibit Short and Narrowly Distributed Telomere Lengths and High Telomerase Activities, Associated with Rapid and Dose-Dependent Cell Death Following Telomerase Inhibition by Imetelstat Sodium." Blood 114, nr 22 (20.11.2009): 2647. http://dx.doi.org/10.1182/blood.v114.22.2647.2647.
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Abstract Abstract 2647 Poster Board II-623 Background/Aims: Reflecting their proliferative history, malignant cells generally have shorter telomeres compared to their normal counterparts. We have reported that leukemic cells from patients with T-prolymphocytic leukaemia (T-PLL) have exceptionally short telomeres (telomere lengths around 1 kb) compared to other malignancies, and high levels of telomerase activity (Roeth et al., Leukemia, 2007). We have also previously presented (Roeth et al., ASCO 2008) cytotoxic effects of the telomerase inhibitory agent imetelstat sodium (GRN163L), which is currently in clinical trials. The objective of this study was to further characterize the relationship between mean telomere length (TL), the single chromosome telomeric size distributions (single TL), telomerase levels and imetelstat-induced telomerase inhibition and cytotoxicity in T-PLL, B-CLL, and normal cells. Methods: Cells were obtained from peripheral blood of normal donors and patients with T-PLL and B-CLL and cryopreserved. TL was measured by flow-FISH (which yields a multicellular average measurement across all chromosomes) and the distribution of individual telomere lengths by single telomere length analysis (STELA, XpYp specific). Telomerase activity (TA) was assessed by TRAP. Effects of imetelstat upon cell survival, apoptosis and TA were studied in short-term cell cultures. Apoptosis was measured by Annexin V-PI double staining. Results: Average (±SD) TL of the T-PLL cells was 1.8 ± 0.73 kb (n=13) which was shorter than for B-CLL cells (ZAP-70+/CD38+ CLL: 2.46 ± 1.08 kb (n=30); ZAP-70neg/CD38neg CLL: 5.06 ± 1.76 kb (n=29), Roeth et al, Br. J. Haem., 2008). T-PLL cells were found to have a narrow range of single chromosome telomere lengths, while both subtypes of B-CLL cells demonstrated a broader distribution of telomere lengths. No attrition of mean telomere length was observed over time in two patients with T-PLL who were followed over time, despite continued clinical progression. In contrast, we have observed that most patients with B-CLL do have decreases in telomere length over the course of their disease. Leukemic T-PLL cells exhibited high levels of telomerase activity, whereas there was little or no detectable telomerase activity in normal, unstimulated T-cells and most B-CLL cells. Imetelstat (GRN163L, Geron Corporation), a potent inhibitor of telomerase, induced significant and dose-dependent inhibition of telomerase activity in T-PLL cells after 2 hours of culture at 1μM and 10μM. Imetelstat significantly reduced cell viability of T-PLL cells in vitro after 7-10 days of culture (viability as % of control (mean ± SD) with 1, 3, 10 μM imetelstat: 69.9 ± 27.3, 51.7 ± 30.2, 37.1 ± 27.6). No significant cytotoxicity of imetelstat was observed in CLL samples, or in unstimulated and stimulated T-cells from 5 normal donors. Leukemic cells from one T-PLL patient early in the course of the disease did not exhibit loss of viability when exposed to imetelstat at levels up to 10 μM; however, when cells from this patient were tested later during the progression of the disease significant cytotoxicity was observed. Conclusions: In summary, leukemic T-PLL cells exhibit extremely short telomere lengths, narrower ranges of single chromosome telomere size distributions, and higher telomerase activity compared to B-CLL cells and normal T cells. These observations may explain why inhibition of telomerase activity in T-PLL cells by imetelstat is associated with rapid and dose-dependent cell death. Disclosures: Baerlocher: Geron Corporation: Research Funding. Bassett:Geron Corporation: Employment, Equity Ownership. Elias:Geron Corporation: Employment, Equity Ownership. Go:Geron Corporation: Employment, Equity Ownership. Roeth:Geron Corporation: Research Funding.
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Young, Mary H., Sam A. Danziger, Alison Fitch, Frank Schmitz, Jake Gockley, Mark McConnell, David Reiss i in. "Deep Immunoprofiling of the Bone Marrow Microenvironmental Changes Underlying the Multistep Progression of Multiple Myeloma". Blood 132, Supplement 1 (29.11.2018): 243. http://dx.doi.org/10.1182/blood-2018-99-113042.
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Abstract Introduction The multistep progression of multiple myeloma from a normal plasma cell to a system with the features of invasive cancer provides a unique opportunity to understand the co-evolution of the malignant clone within its microenvironment. Understanding these changes is becoming increasingly important as we attempt to design early intervention strategies and to precisely leverage emerging immunotherapeutic modalities to prevent and treat disease progression. In this work, we used mass cytometry (CyTOF) to generate a high-resolution map of the BM microenvironment and how it changes during the transition from health through pre-malignancy to disease. This approach allows us to both understand microenvironmental patterns that correlate with rapid disease progression as well as to generate new hypotheses about permissive and protective immune-phenotypes that might reveal novel immunologic drug targets. Methods To understand the immunologic characteristics of monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), newly diagnosed multiple myeloma (NDMM) and relapsed-refractory multiple myeloma (RRMM), we profiled BM aspirates from 79 patients using mass cytometry by time of flight (CyTOF). Furthermore, we compared the BM compartment of pre-malignant, malignant, and relapsed disease states to the BM of healthy donors using a 37-marker pan-immune panel. In this panel, we used antibodies against several immune lineages, tumor antigens, and functional surface markers, including co-stimulatory and co-inhibitory receptors. Cell clusters defined by Citrus analysis of CyTOF data were combined into an evolutionarily optimized decision tree by evtree to identify cluster interactions that strongly partition patient samples. Results During MGUS, when the tumor plasma cells are <10% of BM, there is little evidence of immune dysregulation; the immune compartment of MGUS patients contains normal numbers of innate and adaptive populations. In SMM, there is considerably more heterogeneity, with patients both resembling MGUS/healthy individuals and those that had changes to their immune microenvironment more consistent with newly diagnosed patients. These features include the loss of specific CD4 T cell and B cell subsets (FDR<0.1). The loss of CD4 was the most pronounced in the central memory and effector populations. This reduction in CD4 T cells is important because it diminishes help for CD8 T cell-mediated killing and immune cell maturation. Among B cell subsets, there was a loss in both mature and memory B cells. In comparison of SMM and NDMM samples, there was a clear progression from samples resembling healthy (normal B and CD4 subsets), to loss of only B cell subsets, and finally, loss of both B cell and CD4 subsets as samples diverged from healthy controls (Figure 1). In addition, a supervised machine learning analysis (evtree) identified CD4 effector memory abundance as the top node for partitioning samples into two distinct subtypes based on all available CyTOF markers across the myeloma continuum, with the high and low CD4 effector memory subtypes further subdivided by pre-B/immature B cell abundance (p=0.01), supporting these two cell types as being robust discriminators of the immune microenvironment as disease evolves. Between NDMM and RRMM samples, we observed heterogeneous loss in B cell subsets, including memory and naïve B cells. Interestingly, in RRMM we observed a strong increase in an unidentified population of CD45- cells that are quiescent (FDR<0.1), which may be stem or stromal cells. Available RNA sequencing from matching samples may reveal the lineage and function of these cells that increase during relapse. Conclusions Immune dysregulation is thought to be a major contributor to the progression and outcome of patients with MGUS, SMM, and MM. Using CyTOF, we have begun to benchmark the content of the immune microenvironment across the myeloma continuum. Based on this cross-sectional analysis we hypothesize that it is important to further interrogate whether the losses in the CD4 memory and effector populations we described correlate with outcomes after therapy with either CAR T or T cell engager trials that are currently ongoing, and whether reconstituting these cell types could provide a meaningful treatment strategy. Disclosures Young: Celgene Corporation: Employment, Equity Ownership. Danziger:Celgene Corporation: Employment, Equity Ownership. Fitch:Celgene Corporation: Employment, Equity Ownership. Schmitz:Celgene Corporation: Employment, Equity Ownership. Gockley:Celgene Corporation: Employment. McConnell:Celgene Corporation: Employment. Reiss:Celgene Corporation: Employment, Equity Ownership. Copeland:Celgene Corporation: Employment, Equity Ownership. Newhall:Celgene Corporation: Employment, Equity Ownership. Hershberg:Celgene Corporation: Employment, Equity Ownership, Patents & Royalties. Foy:Celgene Corporation: Employment, Equity Ownership. Ratushny:Celgene Corporation: Employment, Equity Ownership. Dervan:Celgene Corporation: Employment, Equity Ownership. Morgan:Takeda: Consultancy, Honoraria; Janssen: Research Funding; Celgene: Consultancy, Honoraria, Research Funding; Bristol-Myers Squibb: Consultancy, Honoraria.
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Speranzin, Marco. "Benefit Legal Entities in Italy: An Overview". European Company Law 19, Issue 5 (1.10.2022): 142–50. http://dx.doi.org/10.54648/eucl2022023.
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Benefit legal entities combine the normal logic of profit-making with corporate sustainability. They pursue, in addition to the profit purpose, one or more aims of common benefit to be indicated in the articles of association relating to the corporate activity. An initial question is whether the pursuit of these joint objectives (i.e., profit and social responsibility) is reserved solely to benefit corporations and whether (and to which extent) non-benefit legal entities are excluded from pursuing these dual aims. As regards the notion of common benefit, its specification in the articles of association raises some significant legal issues. Firstly, it affects the assessment of the directors’ duty of care; they are required to balance the interests of the shareholders with those other interests provided for in the by-laws, and consequently such balance has potential implications on directors’ liability. Secondly, stakeholders adversely affected by the entity’s failure to achieve those common benefit aims must be protected, but it is difficult to assess how. Finally, setting out a corporation’s common benefit could trigger, under certain conditions, the exit right of dissenting shareholders following the acquisition or loss of the «benefit status». benefit legal entities, directors’ duties, exit right, legal entities pursuing common benefit purposes
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Fonseca, Ingrid, Jayson Bernate i Carlos Cabanzo. "Medición de la Responsabilidad Social Corporativa en organizaciones deportivas: desarrollo y valida-ción de escala, estudio piloto (Measuring Corporate Social Responsibility in sport organizations: scale development and validation, pilot study)". Retos 53 (4.02.2024): 58–68. http://dx.doi.org/10.47197/retos.v53.101720.
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La responsabilidad social corporativa busca dar respuesta a las necesidades de los grupos de interés a través de directrices y normas. Así como dar solución a los impactos ambientales, sociales y económicos de las empresas. Por ello, el propósito de esta investigación fue diseñar y validar una escala de medición de la responsabilidad social corporativa en las organizaciones deportivas. La muestra estuvo conformada por 140 dirigentes de ligas deportivas colombianas. Los resultados de la técnica de análisis factorial exploratorio y confirmatorio a través del Software R validaron cuatro dimensiones: 1) gobierno corporativo, 2) talento humano, 3) stakeholders externos e 4) Impacto de la RSE. La fiabilidad del cuestionario se obtuvo mediante el coeficiente alfa de Cronbach (α =.901). Se destaca que el estudio contribuye al conocimiento científico sobre las propiedades psicométricas de los instrumentos y es una referencia para estudios posteriores sobre cuestionarios de responsabilidad social corporativa en el sector del deporte. Finalmente, se proporciona una escala que puede ser utilizada por investigadores y la comunidad académica. Además, tiene implicaciones prácticas y teóricas para las partes interesadas. En conclusión, el cuestionario es válido, fiable y robusto, con adecuadas propiedades psicométricas. Palabras clave: Responsabilidad Social Corporativa, Clubes deportivos, Desarrollo y validación de escalas, Modelo de medición. Abstract. Corporate social responsibility seeks to respond to the needs of interest groups through guidelines and standards and provide a solution to the environmental, social, and economic impacts of companies to the environmental, social, and economic impacts of companies. Therefore, this research aimed to design and validate a measurement scale of Corporate Social Responsibility in sports organizations. The sample consisted of 140 leaders of Colombian sports leagues and clubs. The results of the exploratory and confirmatory factor analysis technique through Software R validated four dimensions: 1) corporate governance, 2) human capital, 3) external stakeholders, and 4) the Impact of CSR.The reliability of the questionnaire was obtained by Cronbach alpha coefficient (α =.901). The study contributes to the scientific knowledge on the psychometric properties of instruments and this is a reference for instruments and for further studies on corporate social responsibility in the sports sector. Finally, we provide a scale that researchers and the academic community can use. Also, has practical and theoretical implications for stakeholders. In conclusion, the questionnaire is valid, reliable, and robust, with adequate psychometric properties. Keywords: Corporate Social Responsibility, Sports clubs, Development and validation of scales, Measurement model.
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Atici, Gonca, i Guner Gursoy. "Trends of non-financial corporations listed on Borsa Istanbul: Rethinking corporate ownership and governance under COVID-19". Journal of Governance and Regulation 9, nr 3 (2020): 132–43. http://dx.doi.org/10.22495/jgrv9i3art10.
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The purpose of this study is to analyze trends of non-financial corporations listed on Borsa Istanbul (BIST) in terms of ownership structure for the period of 2002-2019. According to our findings, Turkish non-financial corporations reveal a concentrated nature as an example of family capitalism. Findings also reveal that initial public offerings are mainly from family-controlled corporations. This is noteworthy as corporations integrate more to the capital markets of Turkey. Besides, they get more disciplined as they subject to the regulations of the governing bodies and internalise corporate governance criteria. In terms of ownership mix, findings denote that non-financial corporations listed on BIST benefit from the advantages of conglomerates, cross-ownership, and foreign ownership in line with the literature. Contrary to several emerging economies, state-ownership has a minor share which renders strength and quality of governance level. The concentrated nature of corporations is believed to have a positive effect on governance mechanisms for controlling agency problems especially in the environment of uncertainty during COVID-19. Although Turkish capital markets have promising and progressing corporate governance mechanisms, steps to build up advanced digital governance mechanisms for the “digital new normal” should be taken as soon as possible.
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Betancourt Ramírez, Jose Bernardo, Gonzalo Eduardo Gómez Betancourt i Diógenes Lagos Cortés. "Normas vinculantes y no vinculantes en gobierno corporativo: un análisis para la asamblea de accionistas". Entramado 15, nr 2 (30.06.2019): 28–44. http://dx.doi.org/10.18041/1900-3803/entramado.2.5480.
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Este estudio analizó la aplicación de algunas normas vinculantes y no vinculantes de gobierno corporativo en la asamblea de accionistas (frecuencia de las reuniones, antelación en la convocatoria, información previa entregada, decisiones sobre estatutos, dividendos y elección del revisor fiscal) en una muestra de 202 empresas colombianas obtenida a través de una encuesta respondida por correo electrónico. Se usó la prueba Z para comparar proporciones en la aplicación de dichas normas entre empresas familiares y no familiares y entre diferentes tipos de sociedades. Se concluye que los esfuerzos realizados por entidades que promueven el gobierno corporativo aún están lejos de tener una gran acogida en las empresas colombianas. Este trabajo plantea la necesidad de concentrar más y mejores esfuerzos para garantizar que las empresas cumplan al menos con las normas vinculantes, dado que dichas normas terminan siendo débiles en alguna de sus dimensiones (precisión de la norma, obligatoriedad en el cumplimiento, delegación para su interpretación e implementación en un tercero). De igual forma, es deseable mejorar los estándares de gobierno corporativo mediante la adopción de prácticas recomendadas en las normas no vinculantes, que en muchos casos son más rigurosas que la norma vinculante.
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Shkuropadska, Diana. "MACROECONOMIC TOOLS FOR ENSURING RESILIENCE OF THE FINANCIAL CORPORATIONS SECTOR". EUREKA: Social and Humanities 1 (31.01.2020): 16–22. http://dx.doi.org/10.21303/2504-5571.2020.001110.
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Research the tools for ensuring resilience of the financial corporations sector is relevant, given the fact that the development of the world economy is increasingly subject to the shock influences, to which financial crises are imposed. The aim of the article is to identify and justify macroeconomic tools according to the directions for ensuring resilience of the financial corporations sector. The theoretical-methodological base of the article is scientific works of scientists and reports of international organizationsfor directions and tools for ensuring resilience of the financial corporations sector and the economy in general. The general approaches and research methods have been used at preparing the article: theoretical generalization, analysis, synthesis and system method. The use of these methods allowed to consider approaches of leading international audit companies to understand the concept “resilience of the financial corporations”. On this basis, there was suggested the author's definition of the concept “resilience of the financial corporations sector” and defined it essential characteristics. It was explained, that the process of ensuring resilience of the financial corporations sector involves the implementation of macroeconomic tools in accordance with the following areas: the introduction of economic stimulus packages, attractive lending conditions, tax and investment benefits, promoting innovation, development of compensation mechanisms, international financial support. The important attention in the study was paid to the role of the state in the process of implementing macroeconomic tools for ensuring resilience of the financial corporations sector. Attention is focused on the fact, that under shock influences the state should implement macroeconomic tools in line with current problems in the development of the financial corporations sector. This in turn will ensure its profitability at a level sufficient for normal functioning.
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Rozas Flores, Alan Errol. "El Comité de Auditoría". Quipukamayoc 15, nr 29 (16.03.2014): 33. http://dx.doi.org/10.15381/quipu.v15i29.2067.
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A partir de los grandes escándalos corporativos que sacudieron al mundo de los negocios, los comités de auditoría han sido objeto de una redefinición de sus funciones y responsabilidades, lo cual ha llegado hasta la inclusión de éstas en leyes, reglamentos y códigos de mejores prácticas a nivel mundial, llevando a las organizaciones a la necesidad de replantear las estructuras y prácticas de sus comités, así como el reconocer los beneficios que implican el contar con un comité preparado para contribuir al cumplimiento de los objetivos estratégicos de cada organización. Los miembros del comité de auditoría se enfrentan a altas expectativas de varios grupos, lo que incluye a accionistas, activistas de accionistas y de gobierno corporativo, reguladores, los medios de comunicación y los miembros asociados del directorio. La bolsa de Nueva York, en su listado de propuestas tipo, ha sugerido establecer un proceso formal de evaluación para todo el directorio y para cada comité de mayor importancia del directorio, entre ellos el comité de auditoría. Un comité de auditoría (o cuerpo equivalente) es establecido por los miembros del directorio (o junta de directores) de la empresa, con el propósito de supervisar los procesos contables y de presentación de información financiera de la empresa y sus estados financieros. Algunas disposiciones y normas nacionales también estipulan que si no existe tal comité, entonces el comité de auditoría es todo el directorio. La existencia y buen funcionamiento del comité de auditoría son sinónimos de prácticas de buen gobierno corporativo (empresarial). Su efectividad e independencia de actuación genera gran confianza entre socios, inversionistas y acreedores, e incluso de clientes y entidades gubernamentales de supervisión, fiscalización y control. Sin embargo, esto requiere que los miembros de este comité tengan conocimientos, aptitudes, habilidades y experiencia práctica, así como cualidades personales particulares.
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Troccoli, Irene Raguenet, i Felipe Lisboa. "GOVERNANÇA CORPORATIVA NA EMPRESA FAMILIAR:". Revista Vianna Sapiens 9, nr 1 (10.08.2018): 32. http://dx.doi.org/10.31994/rvs.v9i1.291.
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A governança corporativa deve ser uma prioridade para as empresas, pois gera valor para seus acionistas. Este artigo qualitativo investigou a aplicação da governança corporativa em empresa familiar de primeira geração, examinando-se quais princípios de governança do IBGC estão sendo aplicados ou em processo de implantação. Os temas das entrevistas semiestruturadas foram governança na empresa, relações corporativas e assuntos relacionados ao contrato social, normas administrativas, código de ética e planejamento estratégico. O resultado indicou as prioridades de governança e a necessidade de uma reformulação do acordo de acionistas para conter princípios que ajudarão na sustentabilidade e na longevidade da empresa.
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DOPAZO FRAGUÍO, Mª PILAR. "La responsabilidad social corporativa (RSC) como activo facilitador de la innovación jurídica". Revista Jurídica de Investigación e Innovación Educativa (REJIE Nueva Época), nr 13 (1.01.2016): 31–48. http://dx.doi.org/10.24310/rejie.2016.v0i13.7682.
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El presente texto ofrece una reflexión sobre el valor actual de la Responsabilidad Social Corporativa (RSC) o Empresarial (RSE), como disciplina de carácter transversal y digna de estudio en el marco de las Ciencias sociales y jurídicas. El tratamiento de esta materia conlleva varios enfoques (económico, social y medioambiental), por lo que abarca distintas áreas del conocimiento. Si bien, hay que significar que desde una (su) perspectiva jurídica, la RSC ha adquirido una mayor relevancia como presupuesto cualitativo necesario para las entidades empresariales o societarias; y, en especial, con el objetivo de acreditar que disponen de un buen modelo de gobierno corporativo. Lo mencionado, queda hoy patente con motivo de las últimas reformas normativas practicadas en nuestro Ordenamiento jurídico. En este sentido, cabe apreciar como muy positiva la progresiva integración de este valor en el ámbito del Derecho Empresarial y/o del Derecho de Sociedades, en aras de propiciar el paradigma del buen gobierno, ligado a la transparencia y al emprendimiento responsable. A dicho fin, cada entidad o empresa debe acreditar el debido cumplimiento de las normas imperativas, y, además, resulta preciso que adopte compromisos específicos en materia de responsabilidad social y medioambiental; todo ello, conforme a dictar su propio sistema de autorregulación y compliance.
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Siegel, Donald S. "Why Do Corporations Decide to Do Good?" Journal of Economics, Management and Religion 01, nr 01 (lipiec 2020): 2050003. http://dx.doi.org/10.1142/s2737436x2050003x.
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In his highly influential essay, Milton Friedman argued that companies should never engage in “social responsibility,” defined as going beyond regulatory compliance and normal business practices to advance a “social” goal. In contrast, I argue for a more nuanced approach when considering in engaging in these activities. Specifically, I assert that companies should not engage in such activities for “moral” or “ethical” reasons or in response to societal pressure alone, but rather in response to a legitimate demand for ‘social’ practices from groups (e.g. consumers) that can directly benefit the firm. This profit-maximizing approach to ‘social responsibility’ still allows for considerable scope in formulating and implementing strategic initiatives that simultaneously advance corporate and societal goals. Under certain conditions, managers can maximize profit, while also adopting practices that are perceived to be socially responsible.
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Day, Brennan, Ruth Burnice Mckay, Michael Ishman i Ed Chung. "The new normal: lessons learned from SARS for corporations operating in emerging markets". Management Decision 42, nr 6 (lipiec 2004): 794–806. http://dx.doi.org/10.1108/00251740410542357.
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Song, Degang, Michael H. Swartz, Steve G. Biesecker, Fernando Borda, Rutul R. Shah, Peter Emtage, William G. Wierda, Laurence J. N. Cooper i Tim Chan. "Chimeric Antigen Receptor-Modified T Cells for the Treatment of Acute Myeloid Leukemia Expressing CD33". Blood 128, nr 22 (2.12.2016): 4058. http://dx.doi.org/10.1182/blood.v128.22.4058.4058.
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Abstract Relapsed acute myeloid leukemia (AML) is an aggressive disease with very poor outcomes. Redirection of T-cell specificity via chimeric antigen receptor (CAR) has shown promising anti-tumor activity in clinical trials, particularly for B cell linage malignancies. CD33 is a transmembrane protein expressed on normal and malignant myeloid-derived cells as well (as on subsets of activated T cells and NK cells). Since this protein is commonly expressed on AML cells, we sought to evaluate the efficacy of targeting AML with CD33-specific CAR-T cells. We generated a lentiviral construct to co-express CD33-specific CAR and a kill switch based on a tag derived from the epidermal growth factor receptor. The latter allows for the conditional elimination of CAR-T cells in vivo. Following transduction of primary T cells, we confirmed CAR and kill switch co-expression by flow cytometry and western blot analyses. Elimination of genetically modified T cells was demonstrated using the clinically-available antibody, cetuximab. CD33 CAR-T cells demonstrated specific cytotoxicity to CD33+ target cell lines. CD33 CAR-T cells were also activated to produce IFNg, TNF, and IL-2 cytokines in response to CD33+ target cells. Furthermore, adoptive transfer of CD33 CAR-T in immunocompromised (NSG) mice bearing established CD33+(CD19neg) AML (MOLM-13) tumor resulted in reduction of tumor burden and improvement of overall survival, compared to control mice receiving CD19 CAR-T cells or no immunotherapy (Figure). Sampling of blood demonstrated the persistence of the CD33 CAR-T cells with no detection of AML (MOLM-13) tumor cells. These pre-clinical data demonstrate the effectiveness of CD33 CAR-T cells in targeting CD33+ AML tumor cells and provide a rationale for future clinical evaluation in AML patients with unmet medical need. Disclosures Song: Intrexon Corporation: Employment, Equity Ownership. Swartz:Intrexon Corporation: Employment, Equity Ownership. Biesecker:Intrexon Corporation: Employment, Equity Ownership. Borda:Intrexon Corporation: Employment. Shah:Intrexon Corporation: Employment, Equity Ownership. Wierda:Genentech: Research Funding; Gilead: Research Funding; Abbvie: Research Funding; Novartis: Research Funding; Acerta: Research Funding. Cooper:MD Anderson Cancer Center: Employment; Intrexon: Equity Ownership; Sangamo BioSciences: Patents & Royalties; Targazyme,Inc.,: Equity Ownership; City of Hope: Patents & Royalties; ZIOPHARM Oncology: Employment, Equity Ownership, Patents & Royalties; Miltenyi Biotec: Honoraria; Immatics: Equity Ownership. Chan:Intrexon Corporation: Employment, Equity Ownership.
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Sulistiani, Ika, I. GD Yudha Partama, Sang Putu Kaler Surata i I. Ketut Sumantra. "DINAMIKA KUALITAS UDARA AMBIEN SELAMA MASA PANDEMI COVID-19 DI KAWASAN INDONESIA TOURISM DEVELOPMENT CORPORATION NUSA DUA BALI". ECOTROPHIC : Jurnal Ilmu Lingkungan (Journal of Environmental Science) 15, nr 1 (2.06.2021): 124. http://dx.doi.org/10.24843/ejes.2021.v15.i01.p11.
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The Covid-19 pandemic has increased the improvement of air quality in various countries in the world, such as China, Italy, New York, India, Spain and Korea. This study aims to compare ambient air quality during the Covid-19 pandemic with new normal and normal periods, assess the effect of meteorological factors on ambient air quality, and map the spatial distribution of ambient air quality during the normal, Covid-19 pandemic and new normal in the ITDC Nusa Dua area. Air concentration parameter data and meteorological factors were collected using the midget impinger and direct reading method in 2019 (normal period), March and May 2020 (Covid-19 pandemic period) and July, September, and November 2020 (new normal period). Furthermore, comparing air quality using the Anova test, assessing the effect of meteorological factors on air quality using a linear regression test, and mapping the distribution of ambient air using the ArcGis 10.8 application. The analysis showed that the air quality during the Covid-19 pandemic and the new normal was significantly different from the normal period. The concentrations of SO2, NO2, NH3, CO, TSP and H2S during the Covid-19 pandemic and normal just decreased while the O3 concentration increased compared to the normal period. The meteorological factor that affects air quality is the wind speed, the higher the wind speed the lower the O3 concentration. Map of the distribution of spatial concentrations of SO2, NO2, NH3, CO, O3 and H2S in the normal, Covid-19 pandemic and new normal, lowest at the coast point of the peninsula and the highest distribution at the ITDC roundabout, bima statue or influence TSP is the highest spatial concentration of normal distribution at the ITDC roundabout and the bima statue, while the Covid-19 pandemic and normal are only at the coast point of the peninsula beach.Keywords: ambient air quality; Covid-19; pandemic; tourism.
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Rangel Lyne, Lucirene, Magda Lizet Ochoa i José Ignacio Azuela. "El efecto mediador de la norma subjetiva en la relación RSC-warm glow. Una aproximación al análisis de universitarios millennials mejicanos". Teuken Bidikay - Revista Latinoamericana de Investigación en Organizaciones, Ambiente y Sociedad 10, nr 14 (1.01.2019): 43–57. http://dx.doi.org/10.33571/teuken.v10n14a2.
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El warm glow se refiere al beneficio percibido, disfrute y satisfacción a partir del consumo socialmente responsable. Existen variables del comportamiento que pueden incrementar el warm glow en culturas colectivistas como Méjico. Una de estas variables es la norma subjetiva. El objetivo del estudio fue confirmar los efectos catalizadores de la norma subjetiva en la relación Responsabilidad Social Corporativa - warm glow. Para ello se encuestó a 337 universitarios millennials mejicanos de una escuela de negocios. Se reprodujo una regresión con mediación que confirma la construcción de un warm glow motivado por la percepción de la Responsabilidad Social Corporativa y la norma subjetiva; siendo esta última la variable mediadora. Los resultados muestran que el poder explicativo de la Responsabilidad Social Corporativa se incrementa mediante la norma subjetiva para explicar el warm glow.
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Crowe, Simon F., Robyn M. Bittner, Ramona Raggl i Graeme Senior. "The Effect of Item Type on Performance of the Matrix Reasoning Subtest of the WAIS-III in Traumatically Brain Injured and Non Brain-injured Control Participants". Brain Impairment 4, nr 2 (1.12.2003): 146–54. http://dx.doi.org/10.1375/brim.4.2.146.27025.
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AbstractQualitative analysis of neuropsychological instruments has been a long tradition in neuropsychological assessment. This study extended this type of analysis to the Matrix Reasoning (MR) subtest of the WAIS-III. The study compared the performance of TBI participants on the item types identified within the MR subtest (i.e., pattern completion, classification, analogy and serial reasoning) with a group of normal controls. MR items were classified into categories (as defined respectively by the Psychological Corporation and by our own research definition). Ninety-three non brain-injured control and 72 brain injured control participants were included in the study. One way analysis of variance indicated that the TBI group performed significantly worse than the non brain-injured group the MR performance overall as well as for both the Psychological Corporation classification and on the research defined categories. Within group analysis revealed that both groups performed significantly differently across the item categories with the most difficult categories being analogy and serial reasoning for the research defined categories and the classification and serial reasoning categories for the Psychological Corporation-defined groups. The results of the study indicate that an item type analysis of the MR performance may further contribute to the qualitative aspects of diagnostic formulation.
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Delforge, Michel, Igor W. Blau, Miguel T. Hernandez, Roman Hajek, Luciano Masini, Henk Lokhorst, Giacinto La Verde i in. "Post-Approval Safety Study (PASS) of Lenalidomide Compared with Other Treatments In Patients with Relapsed or Refractory Multiple Myeloma: Evaluation of Peripheral Neuropathy In the First 1,011 Patients". Blood 116, nr 21 (19.11.2010): 1939. http://dx.doi.org/10.1182/blood.v116.21.1939.1939.
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Abstract Abstract 1939 Aim and Background: Lenalidomide plus dexamethasone was EMEA approved in 2007 for the treatment of patients with multiple myeloma (MM) who have received at least one prior therapy. Subsequently, an observational patient cohort study was implemented to characterize the safety profile of lenalidomide in clinical practice, and to place the incidence of adverse events (AEs) into context with those occurring in patients with MM receiving other treatments second line or later. A secondary objective of the study was to assess the evolution or resolution of peripheral neuropathy (PN) in patients taking lenalidomide, who had pre-existing PN at baseline. Methods: Data were collected prospectively from 1,011 patients with MM, in 177 institutions in 15 European countries. Patients had received at least one prior therapy and were commencing a new treatment with prescribed medication in accordance with normal clinical practice at the time of enrollment. No additional treatments or investigations outside of normal clinical practice were required. PN status was assessed by physicians according to their normal clinical practice. PN was recorded at baseline and, if present, the status was subsequently recorded at all following data collection points until the patient discontinued study treatment. For those patients who did not have PN at baseline, any new occurrence of PN was documented as an AE. Data cutoff for this analysis was May 4, 2010. Results: Of the 1,011 patients who entered the study, 658 patients started lenalidomide-, 207 bortezomib-, and 53 thalidomide-based therapies; 43 patients commenced other therapies and 50 had missing data. Median Kaplan-Meier estimated treatment duration was 6.4 months for lenalidomide, 3.8 for bortezomib, and 4.8 for thalidomide. Baseline PN was reported in 39% (254/658) of patients in the lenalidomide cohort: 22% (144/658) were reported to be due to previous bortezomib and 18% (118/658) were due to previous thalidomide. In the bortezomib cohort 21% (43/207) had baseline peripheral neuropathy: 3% (6/207) were reported due to previous bortezomib and 13% (27/207) due to previous thalidomide. Baseline PN due to prior vincristine use was low (2% of patients), and non-drug induced PN was between 4–6% in the three cohorts overall. Observed PN in the lenalidomide cohort was 42% (89/213) at baseline and 29% (62/213) at 4 months, compared with 26% at baseline (16/61) and 23% (14/61) at 4 months in the bortezomib cohort. There was no change over the 4 month period in the thalidomide cohort (16% 3/19). Treatment discontinuations due to AEs were highest in the thalidomide cohort (24.5%), and similar in the lenalidomide (14.1%) and bortezomib (15.5%) cohorts. However, patient discontinuations due to PN were six times higher in the bortezomib (4.8%) cohort compared with the lenalidomide cohort (0.8%). The incidence of drug-related PN and grade 3* or 4** drug-related PN was four times lower in the lenalidomide cohort compared with the bortezomib cohort. Conclusion: In this unselected group of patients taken from normal clinical practice and treated with lenalidomide-, bortezomib-, or thalidomide-based therapies, lenalidomide demonstrated a low incidence of drug-related PN. A high proportion of patients commencing treatment with lenalidomide had baseline PN due to their previous anti-myeloma therapy. Preliminary data on these patients at 4 months of treatment indicated a trend towards improvement of PN in patients receiving lenalidomide. Discontinuations due to PN were low in the lenalidomide cohort compared with the bortezomib cohort. Disclosures: Delforge: Celgene Corporation: Consultancy, Honoraria, Speakers Bureau; Ortho-Biotech: Consultancy, Honoraria, Speakers Bureau; Novartis: Consultancy, Honoraria. Hajek:Celgene Corporation: Honoraria; Janssen-Cilag: Honoraria; Merck, Sharp, and Dohme: Honoraria. Lokhorst:Celgene Corporation: Speakers Bureau. Collins:Celgene Corporation: Employment. Rosettani:Celgene Corporation: Employment. Brandenburg:Celgene Corporation: Employment.
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Santana, Vânia Ribeiro de, i Expedito dos Santos Santana. "ANÁLISE DO SISTEMA DE COMPLIANCE NA MITIGAÇÃO DE RISCOS CORPORATIVOS: ESTUDO DE CASO EM UMA EMPRESA DE ADMINISTRAÇÃO HOSPITALAR". Revista Ibero-Americana de Humanidades, Ciências e Educação 10, nr 5 (28.05.2024): 5660–77. http://dx.doi.org/10.51891/rease.v10i5.14281.
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Este estudo visa analisar um sistema de compliance com fatos para redução de riscos corporativos. Por esta razão, o presente trabalho tem como objetivo geral analisar o sistema normativo de compliance e a sua utilidade na mitigação de riscos corporativos em uma empresa de administração hospitalar. Além disso, os objetivos específicos são: descrever o sistema de normas internas da organização; avaliar a efetividade das normas práticas da organização e recomendar práticas de compliance para prevenção de não conformidades e riscos corporativos. Para atingir esses objetivos, utilizou-se por metodologia as pesquisas bibliográficas e empíricas, mediante abordagem quali- quantitativa, para obter dados sobre fatos que ocorrem na organização. Após a realização desta, verificou-se que alguns profissionais de saúde não cumprem com as normas e procedimentos estabelecidos, gerando insatisfação dos pacientes com relação ao atendimento médico, devido à falta de assiduidade, pontualidade e humanização. Sendo assim, foram necessárias recomendações para adotar práticas de compliance a fim de assegurar a conformidade, ética, transparência e eficiência no funcionamento da empresa, elevando a importância de um programa de compliance para minimizar riscos legais e éticos, garantindo a entrega de serviços de alta qualidade aos seus pacientes.
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Lopez-Girona, Antonia, Gang Lu, Emily Rychak, Derek Mendy, Chin-Chun Lu, Irit Rappley, Celia Fontanillo, Brian E. Cathers, Thomas O. Daniel i Joshua Hansen. "CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)". Blood 134, Supplement_1 (13.11.2019): 2703. http://dx.doi.org/10.1182/blood-2019-127892.
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The cereblon E3 ligase modulator (CELMoD) CC-885 co-opts the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex to trigger the ubiquitination and proteasomal degradation of the translation termination factor G1 to S phase transition 1 (GSPT1), resulting in robust growth inhibition in AML cell lines and primary patient blasts (Matyskiela ME, et al. Nature. 2016;535:252-7). However, CC-885 also triggers off-target degradation of other cereblon (CRBN) neosubstrates, potentially leading to toxicities. Here, we present the identification of a novel GSPT1-selective CELMoD, CC-90009, and the mechanistic rationale for its clinical development in relapsed or refractory (R/R) AML (CC-90009-AML-001; NCT02848001). To identify new CELMoD agents, we performed cell-based phenotypic screening using a panel of 11 human AML cell lines harboring common oncogenic mutations. The screening identified CC-90009, which demonstrated potent antiproliferative and proapoptotic activity with 50% inhibitory concentration (IC50) values ranging from 3 to 75 nM in 10 out of 11 cell lines. Maximal apoptosis was reached between 16 and 48 hours post exposure to CC-90009 in 5 AML cell lines with cells being committed to apoptosis within 8-16 hours of treatment. CC-90009 was then tested in a panel of samples obtained from 30 patients with newly diagnosed or R/R AML. Bone marrow aspirates obtained during patient diagnosis were plated without separation of constituent cells and tested for sensitivity to CC-90009 using the PharmaFlow PM test which was reported to predict clinical response to standard-of-care chemotherapy with 81% accuracy in AML (Martínez-Cuadrón D, et al. Leuk Res. 2019;76:1-10). The efficacy of CC-90009 was concentration dependent in 26 of 30 patient samples, with an average half-maximal response concentration (EC50) of 21 nM. Leukemic cell killing was rapid and highly efficient: > 82% of leukemic cells were eliminated within 24 hours and nearly all were eliminated within 96 hours. In contrast, CC-90009 showed only modest activity against normal lymphocytes in the same patient samples. Knockout of CRBN via CRISPR/Cas9-mediated gene editing completely abrogated the activity of CC-90009 in sensitive AML cell lines, suggesting that the anti-AML activity of CC-90009 is mediated by the degradation of GSPT1. Tandem mass tag quantitative mass spectrometry analysis of AML cells treated with CC-90009 revealed that CC-90009 selectively reduced the abundance of GSPT1 with little to no effect on the rest of the proteome. The degradation of GSPT1 by CC-90009 was blocked by proteasomal inhibition or inactivation of the CRL4CRBN E3 ubiquitinligase complex. Overexpression of a GSPT1-degradation-resistant mutant, G575N, conferred complete resistance to CC-90009, while RNA interference (RNAi)-mediated partial knockdown of GSPT1 gene expression enhanced the response to CC-90009. Mechanistically, GSPT1 degradation induced by CC-90009 triggers the activation of the integrated stress response pathway, which is associated with the induction of apoptosis and inhibition of proliferation. CC-90009 is a CELMoD and first-in-class GSPT1 degrader entering clinical development. The degradation of GSPT1 was confirmed to be essential for CC-90009-induced apoptosis and antiproliferative activity. The profound antiproliferative activity of CC-90009 in > 80% of human AML cell lines and patient blasts strongly supports the ongoing phase 1 study in R/R AML. Disclosures Lopez-Girona: Celgene Corporation: Employment. Lu:Celgene Corporation: Employment, Equity Ownership. Rychak:Celgene Corporation: Employment, Equity Ownership. Mendy:Celgene Corporation: Employment. Lu:Celgene Corporation: Employment, Equity Ownership. Rappley:Celgene Corporation: Employment. Fontanillo:Celgene Corporation: Employment. Cathers:Global Blood Therapeutics (GBT): Employment; Celgene Corporation: Equity Ownership. Daniel:Celgene Corporation: Employment. Hansen:Celgene Corporation: Employment.