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Fraser, Tyler Malcolm. "Molecular Dynamics of p21 and Fluorescent Sphingomyelin in Keratinocytes Exposed to UVB". DigitalCommons@CalPoly, 2018. https://digitalcommons.calpoly.edu/theses/1985.
Pełny tekst źródłaHill, Natasha Tremayne. "Vitamin D receptor and 1alpha, 25-dihydroxyvitamin D3 mediated regulation of DeltaNp63alpha". Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1450456950.
Pełny tekst źródłaOnder, Zeynep. "Characterization of the Nucleocytoplasmic Transport of the Cutaneous HPV8 E7 Protein". Thesis, Boston College, 2014. http://hdl.handle.net/2345/3828.
Pełny tekst źródłaSome non melanoma skin cancers (NMSC) have been associated with human papillomavirus (HPV) pathogenesis, like epidermodysplasia verruciformis (EV) and squamous cell carcinoma (SCC). EV is a genetically inherited skin disease that develops when the individuals are infected with cutaneous HPV types belonging to the β-genus, especially types 5 and 8. Transgenic mouse lineages expressing all early genes of cutaneous HPV8 develop papillomas, dysplasias and SCC after UV irradiation and this correlates with enhanced HPV8 oncogenes expression. We have previously discovered that the nuclear localization of mucosal HPV16 E7 and HPV11 E7 proteins is mediated by their zinc-binding domain via a Ran-dependent pathway and independent of nuclear import receptors and that a patch of hydrophobic residues within the zinc-binding domain of HPV16 E7 and HPV11 E7 proteins is responsible for their nuclear import via hydrophobic interactions with FG nucleoporins. Here we investigated the nucleocytoplasmic traffic of cutaneous HPV8 E7 protein using confocal microscopy to analyze the intracellular localization of EGFP-8E7, its subdomains and its mutants after transient transfections. We also investigated the nuclear import ability of GST-8E7, its subdomains and mutants using in vitro nuclear import assays in digitonin-permeabilized HeLa cells. In addition, we performed isolation assays to study the direct interaction between HPV8 E7 and two FG nucleoporins, Nup62 and Nup153 or the nuclear export receptor, CRM1. We found that the nuclear import of cutaneous HPV8 E7 is mediated by a nuclear localization signal (NLS) located within its zinc-binding domain. Furthermore, we determined that the hydrophobic residues within the 65LRLFV69 patch are responsible for the nuclear import and nuclear localization of HPV8 E7 via direct hydrophobic interactions with FG nucleoporins, Nup62 and Nup153, whereas the positively charged arginine 66 plays no significant role in the function of the NLS. In addition, we examined the nuclear export mechanism of cutaneous HPV8 E7 protein and showed that it has a leucine-rich nuclear export signal (NES) in its C-terminal domain that is recognized by the CRM1 nuclear export receptor. These studies are essential for understanding the nucleocytoplasmic traffic of cutaneous HPV8 E7 protein
Thesis (PhD) — Boston College, 2014
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Biology
Kandell, Rebecca Marie. "Assessing the Photoprotective Effects of Fluorescent Sphingomyelin Against UVB Induced DNA Damage in Human Keratinocytes". DigitalCommons@CalPoly, 2018. https://digitalcommons.calpoly.edu/theses/1872.
Pełny tekst źródłaAlshammari, Eid Salem. "∆Np63α Positively Regulates ERK3 Expression in Non-Melanoma Skin Cancer". Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1556229754222487.
Pełny tekst źródłaCERAOLO, MARIA GRAZIA. "DEREGULATION OF UV-ACTIVATED INFLAMMASOME BY HPV 38 IN HUMAN KERATINOCYTES". Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/543118.
Pełny tekst źródłaNon-melanoma skin cancers (NMSC) are the most common human malignancies occurring in fair-skinned adult population, representing approximately 30% of total cancer. The etiology of this cancer is multifactorial, since genotypic, phenotypic and/or environmental factors can be involved in its development. Several studies have reported that the exposure to ultraviolet irradiation (UVB) represents a key risk factor in the development of skin cancer. Furthermore, infectious agents could be an additional risk factor and this hypothesis is supported by the evidence that immunocompromised people, e.g. organ transplant recipients (OTRs), show a higher risk of developing NMSC compared with immunocompetent individuals. Several infectious agents are able to colonize the skin and especially a subgroup of beta cutaneous human papillomavirus (HPV) is considered the most likely additional etiological factors of NMSC. In particular, the presence of β-HPV has been reported in patients with a rare cell-mediated immunity disorder, called epidermodysplasia verruciformis (EV), which causes high rates of susceptibility to develop skin squamous cell carcinoma (SCC) on sun-exposed areas. Thus, it provided the initial clues about infectious agents, such as β HPV, as potential additional risk factor for NMSC. Several studies have demonstrated the transforming properties of the viral oncoproteins, E6 and E7, in in vitro and in vivo experimental models. Both proteins, altering the functions of tumour suppressor gene products, e.g. p53 and retinoblastoma (pRb), are able to deregulate key cellular events, such as cell cycle, DNA repair, apoptosis and senescence. Based on these in vitro results, our group has generated a transgenic (Tg) mouse model that express E6 and E7 oncogenes from beta HPV38 in the basal level of the skin and mucosal epithelia. Those mice were highly susceptible to UV-radiation; in fact, the exposure of HPV38 E6/E7 Tg mice to UVB caused the development of actinic keratosis-like lesions that are considered as precursors of SCC in humans and a few week later SCC. Conversely, the wild-type mice did not develop any type of skin lesions when exposed to the same dose of UV radiations. However, the mechanism of the UV/HPV38 cooperation has not been elucidated yet. The aim of this work thesis was to dissect the molecular mechanisms of such cooperation. We have first determined whether the expression of the viral oncogenes in the Tg animals alters the pattern of gene expression induced by UV radiation. The analysis of the entire transcriptome pointed out that more than 300 genes are deregulated in the Tg mice after UVB exposure, compared to the wild type animals. In particular, the HPV38 E6 and E7 oncoproteins were able to down regulate the expression of proteins involved in the inflammasome complexes or the downstream effectors, such as IL-18. Interestingly, many studies in keratinocyte cell lines provided evidence that UV radiation activate the inflammasome pathway, leading the secretion of specific pro-inflammatory cytokines, like IL-1β and IL-18. RT-qPCR experiments confirmed the transcriptome findings, showing that IL-18 expression is up-regulated in wild-type mice after UV exposure, while it is strongly inhibited in HPV38 E6/E7 Tg mice. Using primary human keratinocytes (HPKs) as experimental models, we dissected the mechanisms involved in the UV-induced IL-18 expression as well as the role of HPV38 in the deregulation of these events. RT-qPCR analysis showed an UV-induced upregulation of IL-18 mRNA expression as well as some key inflammasome components, like AIM2 and ASC, in HPKs cells; conversely, the presence of E6 and E7 oncoproteins strongly down regulated IL-18 both at the expression and secretion levels. Using another in vitro experimental model, such as keratinocytes expressing the human telomerase reverse transcriptase gene (hTERT), in order to prolong the life span of the cells, we found that this cell line presents a higher basal level of IL-18 compared to HPKs and the presence of E6 and E7 plays an inhibitory role. Transient transfection experiments in hTERT HPKs using a vector containing the isolated IL-18 promoter cloned in front the luciferase reporter gene confirmed the ability of HPV38 E6 and E7 to repress the IL-18 promoter activity. The analysis of IL-18 promoter by TFBIND bioinformatics tool revealed the presence of 15 putative binding sites for p53, which is well known to be activated by UV radiation. Performing chromatin immunoprecipitation assays (CHIP), we showed that p53 is recruited to two distinct regions of the IL-18 promoters that includes four p53 responsive elements. Importantly, HPV38 E6 and E7 efficiently prevent p53 recruitment to these IL-18 promoter regions. Together these results corroborated our hypothesis that beta HPV38 play an important role in the inhibition UV-induce inflammasome response, by altering the gene expression and the production of proteins involved in the inflammasome pathways as well as of specific cytokines (e.g. IL-18). Most likely, the down regulation of IL-18 may impair the ability of the keratinocytes to recruit the immune cell population at the UV-exposed area, causing a defect in the elimination of cells harboring DNA damage. In conclusion, all these alterations may lead to the accumulation of UV-induced DNA damage and development of non-melanoma skin cancer.
Norburn, Jill. "NATIONAL MERIT FINALISTS AT THE UNIVERSITY OF CENTRAL FLORIDA-TRENDS, ATTRITION, AND RETENTION1997-2005". Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4069.
Pełny tekst źródłaEd.D.
Department of Educational Research, Technology and Leadership
Education
Educational Leadership
Westphal, Kathi. "Molekulare Mechanismen kutaner humaner Papillomviren (HPV) während der Hautkarzinogenese". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15998.
Pełny tekst źródłaIn the last years epidemiologic and molecular biological studies accumulated increasing evidence that cutaneous human papillomaviruses are etiologically involved in the formation of non-melanoma skin cancer (NMSC). The presented work aims to identify the underlying molecular mechanisms of the viral proteins E6 and E7 of cutaneous HPV types. The E6 and E7 genes of the different HPV types 1, 4, 5, 8, 20, and RTRX7, which are in vivo associated with cutaneous benign or malignant lesions, were studied. Natural host cells of these viruses, human primary keratinocyts (HPK) of the skin, were infected with recombinant E6 and E7 encoding retroviruses. The following analyses were performed in monolayer culture (non-differentiated keratinocytes) or in organotypic skin culture (induction of keratinocyte differentiation). The expression of E6 and E7 elongated the life span of monolayer HPK and significantly increased the doubling rate. An activation of the telomerase, characteristic for immortalized cells, was only detected in HPV 8 E6 positive cells. In organotypic skin cultures E7 of HPV 1, 4 and 38 induced drastic changes in differentiation and proliferation. Additionally an impairment of the normal cell cycle control in suprabasale HPV 5 E7 and 8 E7 cultures was seen. Hints for a strong invasive potential of E7 infected HPK were proven for HPV 8 E7 and expanded to HPV 4 E7, HPV 38 E7 and RTRX E7. The viral E6 and E7 genes of cutaneous and mucosal HPV types exhibit different molecular mechanisms. The multistep model of carcinogenesis includes a series of fundamental cell transformations necessary for tumorigenesis. Mechanisms for the modulation of cell differentiation and proliferation by cutaneous HPV types 4, 5, 8 and 38 described in this work could potentially contribute to the induction and progression of early stages of squamous cell carcinoma.
Barra, Tiago Bruno Areal. "O papel formativo do Movimento Nacional dos Meninos e Meninas de Rua (MNMMR) na comunidade do Lagamar atravÃs da perspectiva dos participantes: uma experiÃncia de construÃÃo da resiliÃncia e empoderamento". Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14035.
Pełny tekst źródłaA sociedade tem passado por um conjunto de transformaÃÃes em sua estrutura. Um dos aspectos mais interessantes dessa transformaÃÃo à observar como a juventude passa por tais mudanÃas de maneira rÃpida, mas nem sempre guiada pelo aspecto qualitativo desse processo. A juventude, principalmente da periferia, està sendo vÃtima de uma ordem social que se estrutura na Ãtica da desumanizaÃÃo. Tendo como base essa premissa, a presente pesquisa tem como objetivo compreender o papel formativo do Movimento Nacional dos Meninos e Meninas de Rua (MNMMR) na Comunidade do Lagamar atravÃs da perspectiva dos participantes, observando esse processo dentro de uma experiÃncia de construÃÃo da resiliÃncia e do empoderamento. Para compreender esse processo formativo (MACEDO, 2010), utilizei da construÃÃo das histÃrias de vida (DELORY-MOMBERGER, 2008; FERRAROTTI, 1996; NÃVOA & FINGER, 2010; PINEAU, 2006, 2012), de acordo com os procedimentos da entrevista narrativa (JOVCHELOVITCH & BAUER, 2002) buscando compor traÃos identitÃrios importantes do MNMMR do Cearà que acaba por completar 30 anos de histÃria em 2015. A categoria da resiliÃncia (ANTUNES, 2011; ASSIS, 2006; CYRULNIK, 2004, 2012; MELILLO & OJEDA, 2005; POLETTI, 2013; YUNES, 2003) e do empoderamento forjado no processo de lutas e conquistas sociais (FREIRE, 1983, 1986, 2006; LOBO, 2011; SAWAIA, 2008) ajudam a compreender esse processo de exclusÃo social e de tomada de consciÃncia crÃtica frente Ãs adversidades sociais. Nas histÃrias de vida, fica evidenciado a importÃncia social do MNMMR, tornando-se um movimento social importante para a Comunidade do Lagamar por atuar com os sujeitos em situaÃÃo de rua. A relevÃncia mostra que as dimensÃes de resiliÃncia e do empoderamento, podem servir de significados para a melhoria de uma formaÃÃo humana propiciada pelo prÃprio MNMMR. O presente trabalho investigativo traz à tona um diÃlogo formativo, que contempla tambÃm um processo educativo, uma aÃÃo educativa construÃda no seio da rua, tendo como protagonista a juventude da periferia da cidade de Fortaleza.
Dang-Heine, Chantip. "Genexpressionsprofil und Aktivität humaner Papillomviren in nicht-melanozytären Hauttumoren". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16152.
Pełny tekst źródłaDuring development of non-melanoma skin cancer, several risk factors are involved: UV-exposition, pigmentation, age, and potentially human papilloma virus (HPV). The molecular mechanisms underlying tumourgenesis in squamous cell carcinoma (SCC) and its pre-cancerosis actinic keratosis (AK) are not fully understood. In this study, the gene expression profile and HPV-infection status were analysed in SCC from immunocompetent and organ transplanted, immunocompromised patients.By global transcriptome analysis from cutaneous SCC, AK and healthy skin, 118 genes were identified differentially expressed in a cDNA-microarray. The expression of 11 out of 13 selected genes (85%) was investigated by real-time RT-PCR (qPCR) and the expression of three genes remarkably induced in SCC correlated with the progression to AK until SCC. These genes encoded for Metalloproteinase-1, which is involved in the remodelling of extracellular matrix, and the protooncogene RAB31 and Tenascin-C (Tn-C). Tn-C protein is expressed in SCC-tissue at the invasion front in basal cells and in keratinocytes in the Stratum papillare and retikulare, but not in healthy skin. This study, the 2243 bp Tn-C-specific splice-variant has for the first time detected in SCC, but not in normal skin. Thus it might serve as diagnostic marker of SCC progression. The data of the transcriptome analysis indicates that a simultaneous dysregulation of oncogene expression and DNA-repair, cell-cycle and proliferation, proteolysis and adhesion molecules exists in SCC. Additionally, the expression of HPV in SCC and thus the causal relationship between HPV-infection and tumourgenesis of SCC in immunocompromised patients was investigated. The HPV-infection pattern in SCC-tissue and normal skin was assessed by detection of DNA from cutaneous HPV-types. Viral E6/E7-mRNA-transcripts of the cutaneous HPV-types 8, 9, 15 were expressed selectively in AK and SCC. In contrast, no HPV-specific mRNA was present in HPV-DNA positive normal skin. The analysis of the open reading frame from the respective E6-protein genes unravelled one single pointmutation, which is not been characterized so far in terms of e.g. its impact on protein structure. The viral activity of the oncogenes E6 and E7 of cutaneous HPV-types indicates a potential function of HPV in the tumourgenesis of SCC in immunocompromised individuals.
Castellanos, Amber. "The Role of IGF-1 In Geriatric Skin". Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1588759288275605.
Pełny tekst źródłaAshton, Kevin John, i K. Ashton@griffith edu au. "Genetic Aberrations in Non-Melanoma Skin Cancer". Griffith University. School of Health Science, 2002. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030818.122305.
Pełny tekst źródłaKRISHNAMURTHY, HARIKRISHNAN N. "SQUARE AND HEXAGONAL SLOTTED SPIRAL ANTENNAS FOR 3D-NMIC". University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1132018374.
Pełny tekst źródłaHenry, Marie-Louise. "Non-thyroid malignancies in familial non-medullary thyroid cancer". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555088063551251.
Pełny tekst źródłaRibeiro, Tiago Trindade. "Controladores NMPC descentralizados para o controle de formação de robôs móveis". Escola Politécnica, 2017. http://repositorio.ufba.br/ri/handle/ri/22631.
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Nesta tese propõe-se o projeto e o desenvolvimento de controladores de formação descentralizados para robôs móveis de diferentes tipos. As soluções baseiam-se na utilização de controladores preditivos não lineares NMPC de tempo contínuo para o cálculo das referências de pose e velocidade para cada robô da formação acoplados via função objetivo ou estados. A tarefa definida para os robôs em formação é o seguimento de caminhos espaciais, pré definidos ou adquiridos através de informações visuais, caso em que o controle é realizado diretamente no plano da imagem, através da utilização de características visuais simplificadas. Para o tratamento de formações e caminhos variantes no tempo, propõe-se uma abordagem para garantia de factibilidade recursiva sem demasiado aumento da complexidade algorítmica dos controladores locais. Tal abordagem baseia-se no relaxamento das restrições do problema de otimização sem penalização explícita na função objetivo. São apresentadas duas propostas para o controle de formação utilizando informações visuais, uma baseia-se num novo conceito de câmeras e caminhos virtuais e a outra implementa a estratégia líder seguidor tradicional. Decorrente da não linearidade dos modelos obtidos, surgem limitações nos horizontes de predição e controle, interferindo diretamente nos requisitos de estabilidade. Neste caso, a estabilidade é garantida através da adição de um custo terminal às funções objetivo e uma zona terminal para as restrições. Resultados simulados e experimentais são apresentados para demonstrar o desempenho das estratégias propostas em diversas situações.
This thesis proposes the design and the development of decentralized formation controllers for di erent types of mobile robots. The solutions are based on the use of continuous time non-linear model predictive formation controllers NMPC for the calculus of references of poses and velocity. The task de ned for the robots in formation are to track spacial paths, pre-speci ed or acquired through visual information, in wich case the control is accomplished direct from the image plane. For the handling of time-varying formations and paths, an approach is proposed to guarantee recursive feasibility without too much increase of the algorithmic complexity of the local controllers. Such an approach is based on the constraints relaxation of the optimization problem without any explicit penalty in the objective function. Two approaches are presented for Formation control using visual information, one based on a new concept of virtual cameras and paths and the other one implements the traditional Leader-Follower strategy. Due to the non-linearity of the obtained models, limitations on prediction and control horizons arise, directly interfering on the stability requirements. Simulated and experimental results are shown to demonstrate the good performance of the proposed strategies in di erent situations.
Basa, Srinivas, i Naveen Ganji. "Enhanced NMS Tool Architecture for Discovery and Monitoring of Nodes". Thesis, Blekinge Tekniska Högskola, Avdelningen för för interaktion och systemdesign, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5473.
Pełny tekst źródła0045-31272355, basasrinu@yahoo.co.in,ji_nav@yahoo.co.in
Gauravaram, Praveen Srinivasa. "Cryptographic hash functions : cryptanalysis, design and applications". Queensland University of Technology, 2007. http://eprints.qut.edu.au/16372/.
Pełny tekst źródłaGauravaram, Praveen. "Cryptographic hash functions : cryptanalysis, design and applications". Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16372/1/Praveen_Gauravaram_Thesis.pdf.
Pełny tekst źródłaJonsson, Robin, i Simon Blixt. "Distribution and configuration of agents for NMS in a reasonable time". Thesis, Linnéuniversitetet, Institutionen för datavetenskap (DV), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-29518.
Pełny tekst źródłaGong, Xingyi. "A comparison of NMHC oxidation mechanisms using specified gas mixtures and trace-P field data". Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11142005-045424/.
Pełny tekst źródłaDavis, Douglas, Committee Chair ; Cunnold, Derek, Committee Member ; Mulholland, James, Committee Member ; Wang, Yuhang, Committee Member ; Wine, Paul, Committee Member. Vita. Includes bibliographical references.
Quachio, Raphael. "Identificação de sistemas não-lineares de modelos com estrutura de Wiener e Hammerstein para NMPC". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/3/3139/tde-07022019-104111/.
Pełny tekst źródłaThis thesis focuses on obtaining models that may produce a better performance of Model-based Predictive Controllers (MPC). Several papers published in the last 25 years have proposed methods based on the minimization of multi-step ahead prediction functions, which are inherently nonlinear. These methods have been called MPC Relevant Identification (MRI). Most of the papers focused on obtaining linear models. In the last 5 years, some methods have been proposed to obtain nonlinear models based on the minimization of the same cost function. These papers were based on the direct minimization of the nonlinear cost function to produce models with NARMAX (nonlinear Autoregressive Moving Average with exogenous inputs) structure. However, simplified MPC schemes may be obtained using models with Wiener and Hammerstein structures. This thesis presents new theoretical results which allow the development of MRI identification algorithms for models with Wiener and Hammerstein structures, without the need to perform the minimization of the nonlinear cost function. Besides the proof of theoretical results, new algorithms are developed and have their prediction capability statistical properties and performance in nonlinear MPC controllers evaluated.
Graham, John J. (John James) 1969. "Seasonal measurements of nonmethane hydrocarbons (NMHC) in a sub-tropical evergreen forest in Southern China". Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/53037.
Pełny tekst źródłaIncludes bibliographical references (p. 169-180).
by John J. Graham, Jr.
Ph.D.
Casso, Christopher Chay. "Distribution of NMHC ratios in the Pacific during PEM-West B and PEM-Tropics A". Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/114093.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (pages 21-22).
Under the auspices of NASA's Global Tropospheric Experiment (GTE), the Pacific Exploratory Missions (PEM) have collected numerous air samples of many regions of the troposphere. Data from PEM-West B (February 7 to March 15, 1994), and PEM-Tropics A (August 15 to October 5, 1996) have been used here to study non-methane hydrocarbon (NMHC) ratios and to compare pollution transport by large scale convection and subsidence, as well as horizontal transport across the Pacific. For PEM-Tropics A, 7 cases are studied, each involving different aspects of transport. Persistent circulation features in the South Pacific played a significant role in NIMHC ratio distribution and processing. For PEM-West B, sources of a large pollution region are studied and compared to equatorial transport. NMHC ratios were found to be useful tracers of pollution distribution through the troposphere. The contrasts of these ratios across relatively small distances, particularly on either side of the South Pacific Convergence Zone in PEM-Tropics A, suggest that convection shapes pollution transport and distribution, particularly in the South Pacific.
This work was supported by the NASA GTE program under grant NAG1-1758 and NAG1-2173
by Christopher Chay Casso.
S.B.
Murali, madhavan rathai Karthik. "Synthesis and real-time implementation of parameterized NMPC schemes for automotive semi-active suspension systems". Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALT052.
Pełny tekst źródłaThis thesis discusses the synthesis and real-time (RT) implementation of parameterized Nonlinear Model Predictive Control (pNMPC) schemes for automotive semi-active suspension systems. The pNMPC scheme uses a black-box simulation-based optimization method. The crux of the method is to finitely parameterize the input profile and simulate the system for each parameterized input and obtain the approximate objective and constraint violation value for the pNMPC problem. With the obtained results from the simulation, the input with minimum objective value or the least constraint violation value is selected and injected into the system and this is repeated in a receding horizon fashion. The method was experimentally validated on dSPACE MicroAutoBoX II (MABXII) and the results display good performance of the proposed approach. The pNMPC method was also augmented to parallelized pNMPC and the proposed method was implemented for control of semi-active suspension system for a half car vehicle. This method was implemented by virtue of Graphic Processing Units (GPUs) which serves as a paragon platform for implementation of parallel algorithms through its multi-core processors. Also, a stochastic version of the parallelized pNMPC method is proposed which is termed as Scenario-Stochastic pNMPC (SS-pNMPC) scheme and the method was implemented and tested on several NVIDIA embedded boards to verify and validate the RT feasibility of the proposed method for control of semi-active suspension system for a half car vehicle. In general, the parallelized pNMPC schemes provide good performance and also, fares well for large input parameterization space. Finally, the thesis proposes a software tool termed “pNMPC – A code generation software tool for implementation of derivative free pNMPC scheme for embedded control systems”. The code generation software (S/W) tool was programmed in C/C++ and also, provides interface to MATLAB/Simulink. The S/W tested for variety of examples both in simulation as well as on RT embedded hardware (MABXII) and the results looks promising and viable for RT implementation for real world applications. The code generation S/W tool also includes GPU code generation feature for parallel implementation. To conclude, the thesis was conducted under the purview of the EMPHYSIS project and the goals of the project align with this thesis and the proposed pNMPC methods are amenable with eFMI standard
Lindqvist, Daniel. "Simulation of Intermittent Current Interruption measurements on NMC-based lithium-ion batteries". Thesis, Uppsala universitet, Strukturkemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325298.
Pełny tekst źródłaZheng, Jiangfen. "A model study of the influence of NMHC and NOx emissions on rural O₃ concentrations in Georgia". Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/25592.
Pełny tekst źródłaPollmann, Jan. "Quantifying the OH radical by global scale NMHC measurements from the NOAA - ESRL cooperative flask sampling network". Mainz : International Max Planck Research School, 2007. http://ubm.opus.hbz-nrw.de/volltexte/2007/1438/pdf/diss.pdf.
Pełny tekst źródłaFeng, Tianyang, i You Zhou. "Disturbing Sound Cancellation Using System Identification". Thesis, University of Gävle, Department of Electronics, Mathematics and Natural Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-7317.
Pełny tekst źródłaDisturbing sound sometimes should be cancelled when music has been recorded. In this thesis, MATLAB was used as a tool. System identification was a main method used to find the unknown system. By subtracting the simulated output, disturbing sound was cancelled. Two different systems were identified with both linear (ARX) model and nonlinear (Parallel Hammerstein) model. The quality of these models was measured and compared using different methods. Possibility to implement this work on hardware was also discussed.
Berglund, Anna. "Simulating Li-ion battery ageing through solid electrolyte interphase growth in graphite/NMC cells". Thesis, Uppsala universitet, Strukturkemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334651.
Pełny tekst źródłaWarnecke, Alexander Johannes [Verfasser], Dirk Uwe [Akademischer Betreuer] Sauer i M. [Akademischer Betreuer] Danzer. "Degradation Mechanisms in NMC-Based Lithium-Ion Batteries / Alexander Johannes Warnecke ; Dirk Uwe Sauer, M. Danzer". Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1161809015/34.
Pełny tekst źródłaZalles, Nicole. "Effects of MicroRNA modulation of PLK1 in Breast Cancer in combination with PLK1 inhibitor NMS-P937". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1554130079416561.
Pełny tekst źródłaAlazzouzi, Hafid. "La inestabilidad genómica en cáncer". Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/3560.
Pełny tekst źródłaAdemás del defecto en MMR, las alteraciones de los microsatélites en zonas no codificantes podrían tener otras causas. Por este motivo, hemos utilizado un modelo alternativo (DNA mitocondrial) para evaluar si estas alteraciones dependerán solamente del MMR como se ha postulado anteriormente. Las mutaciones somáticas en la secuencia D310 mitocondrial se ha asociado con la progresión tumoral. La inserción o la deleción de nucleótidos se ha encontrado en varios tipos de tumores. La frecuencia de mutaciones en tumores de colon, estómago u endometrio es de 23, 17 y 11%, respectivamente, que es paralelo al grado relativo de MSI observado en tumores con deficiencia en MMR (colon > estómago > endometrio, ratio relativo 10:8:4). Los tumores de colon con mutaciones de +1 nucleótido se ha observado en tumores de estadios avanzados de progresión. Se han identificado dos tumores con una mutación de T > C que restauró una repetición homoplasmica, con deleciones de secuencias de 4 y 6 nucleótidos. Estos resultados demuestran que el incremento mutacional de la secuencia repetitiva mitocondrial depende de la estructura repetitiva del DNA y no es resultado del proceso selectivo durante la tumorogénesis. Estos resultados sugieren que D310 se podría utilizar como reloj molecular para evaluar la historia replicativa de los tumores.
La última parte de este estudio se concentra en el análisis de los microsatélites en zonas codificantes y el efecto que podría tener en el proceso tumorogénico. Estas alteraciones podrían cambiar el comportamiento de varias vías donde están implicados estos genes.
El mantenimiento de la estabilidad genómica depende de una respuesta celular apropiada al daño y la integridad del sistema de reparación del DNA. Hemos analizado varios genes diana implicados en estas 2 vías en tumores con MSI. Hemos encontrado una alta frecuencia de mutaciones en los genes ATR (21%), MED1 (43%), hMSH3 (56%) y hMSH6 (43%). También se ha detectado una baja frecuencia en CHK1 (9% de los tumores). Estos resultados confirman que ATR, MED1 y CHK1 son genes diana en el proceso tumoral de estómago, y también sugiere que MED1 junto con hMSH3 y hMSH6 aumentan la inestabilidad genómica considerándolos como mutadores segundarios. Además, estos resultados sugieren la inhibición de la vía de respuesta de daño genómico que depende de ATR y CHK1 y que probablemente está implicada en el proceso tumoral en tumores gástricos con MSI.
Microsatellite instability (MSI) characterizes tumors arising in patients with HNPCC syndrome. In these tumors, the loss of MMR compromises the genome integrity, allowing the progressive accumulation of mutations and the establishment of a mutator phenotype in a recessive manner. It is not clear, however, whether MSI can be detected in HNPCC carriers before tumor diagnosis. The aim of this study was to evaluate the presence of genetic instability in MMR gene carriers in peripheral blood lymphocytes of carriers and non-carriers members of two HNPCC families harboring a germline MLH1 and MSH2 mutation, respectively. An extensive analysis of the allelic distribution of single molecules of the polyA tract bat26 was performed using a highly sensitive PCR-cloning approach. In non-carriers, the allelic distribution of single bat26 molecules followed a gaussian distribution with no bat26 alleles shorter than (A)21. All mutation carriers showed unstable alleles with an overall frequency of 5.6%. We therefore suggest that low levels of genomic instability characterize MMR mutation carriers. These observations suggest that somatic mutations accumulate well before tumor diagnosis. Even though it is not clear whether this is due to the presence of a small percentage of cells with lost MMR or due to MMR haploinsufficiency, detection of these short unstable alleles might help in the identification of asymptomatic carriers belonging to families with no detectable MMR gene mutations.
In addition to the defect in MMR, alterations of microsatellites in no- coding regions may have other causes. For this reason we have used an alternative model (mitocondrial DNA) to evaluate if these alterations depend only on the defects of the MMR, as previously thought. Somatic mutations at a mitochondrial noncoding polycytidine D310 repeat have been associated with tumor progression. We analyzed whether these alterations are due to the inherent mutability of repeated sequences. Insertion and deletion mutations were found in colon, stomach, endometrium, breast, lung, and prostate tumors. The mutation frequency in colon, gastric, and endometrial tumors was 23, 17, and 11% respectively, which paralleled the relative extent of microsatellite instability in long mononucleotide repeats observed in tumors with mismatch repair deficiency (colon > stomach > endometrium, relative ratio 10:8:4). Colon tumors with mutations of more than one nucleotide were more advanced in tumor progression. Further, two tumors showing a T > C mutation that restored the homopolymeric repeat, harbored sequential deletion mutations of 4 and 6 nucleotides. These results illustrate that the increased mutability of repeated mitochondrial sequences is dependent on the repetitive structure of the DNA molecule and suggest that mutations in the D310, whether homoplasmic or not, and by extrapolation, mitochondrial mutations in general, are not the result of selective pressure during tumorigenesis. We also suggest that the D310 may be used as an universal molecular clock to estimate the relative mitotic history of tumors.
The last part of this thesis concentrates in studying the alterations of microsatellites in coding regions and the effect that these will have in tumorogenesis process. Alteration in these genes sequences may be change the behaviour comportment of several pathways..
Maintenance of genomic stability depends on the appropriate cellular responses to DNA damage and the integrity of the DNA repair systems. We analyzed stomach tumors with MSI for frameshift mutations in several potential targets of the mutator phenotype involved in DNA damage-response pathways, and DNA repair system. High frequency of mutations was found within ATR (21%), MED1 (43%), hMSH3 (56%) and hMSH6 (43%) genes. Also, a low frequency of mutations within the CHK1 gene was detected in 9% of tumors. These results confirm ATR, MED1 and CHK1 as targets of the mutator pathway in stomach tumorigenesis, and also suggest a potential role of MED1 increasing, together with hMSH3 and hMSH6, the genomic instability in the mutator pathway as a secondary mutator. Furthermore, these results suggest that the inhibition of the ATR-CHK1 DNA damage-response pathway might be involved in the tumorigenesis of gastric cancer with MSI.
Norén, Christoffer. "Path Planning for Autonomous Heavy Duty Vehicles using Nonlinear Model Predictive Control". Thesis, Linköpings universitet, Reglerteknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-95547.
Pełny tekst źródłaNilsson, Kristoffer, i Ashour Shamoun. "Nätverksövervakning : En jämförelse av Sensu och op5 Monitor". Thesis, Linnéuniversitetet, Institutionen för datavetenskap (DV), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-35054.
Pełny tekst źródłaThe report describes the work and results of a comparison between Sensu and op5 Monitor, which are both tools used to monitor devices in a network, more commonly known as network monitoring systems. The subject was chosen due to the fact that there is such a wide range of network monitoring systems, and it is constantly expanding. It was considered valuable to compare a newcomer with an older tool that is built with a different mindset. It was considered interesting to test how these tools handled the reports created and collected by them, to see if the final results from this would differ or not. To test this a virtual testing environment was built, where Sensu and op5 Monitor were run in parallel to each other and monitored the same systems and used the same set of plugins. The experiments were conducted on two services, BIND9 and Apache2, since the plugins were constructed in different ways, so were the various experiments. In these experiments information was gathered about how the two monitoring tools handled the reports they received, which was then compiled and analysed. The conclusion of it all was that Sensu and op5 Monitor handles the collected information in a similar manner. The reported results were in all cases the same, thus the two monitoring tools behave in the same fashion.
Laurita, Angelica. "Characterisation of the surface reactivity of Ni-rich positive electrode materials for Li-ion batteries". Thesis, Nantes Université, 2022. http://www.theses.fr/2022NANU4025.
Pełny tekst źródłaThe electrification of vehicles is currently based on the use of Lithium-ion batteries using lamellar oxides of nickel, manganese and cobalt (NMC) as positive electrode materials. At the industrial level, the production of nickel-rich materials is now the main focus in order to satisfy the need for longer range battery performances demanded by consumers. However, these materials are affected by strong outgassing during battery cycling. Several studies have been conducted to define the main factors contributing to this outgassing and to find the best solutions to reduce it. The majority of this research, though, focuses exclusively on observing the materials during cycling. To address the necessity of a systematic characterisation of Ni rich NMC in its initial state, the surfaces of several industrial samples were observed using different analytical techniques. 7Li MAS-NMR, XPS, STEM-EELS and SEM-FIB were used to obtain a thorough description of the materials and their surfaces. The limitations and complementarities of each technique are discussed and the results obtained compared and exploited in a synergistic way. It was thus possible to describe in detail the surface of the material in its initial state at the nanometric scale and to evaluate the influence of the storage conditions, as well as the electrode preparation steps. The procedure thus defined could then be used to analyse the surface of materials from different synthesis methods
Rudeklint, Robin. "En kartläggning av nätverksövervakningssystem". Thesis, University of Skövde, School of Humanities and Informatics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-4053.
Pełny tekst źródłaRapporten tar upp en kartläggning av nätverksövervakningssystem (NMS) som används för att övervaka nätverkstjänster och noder på ett nätverk. De egenskaper för NMS som utvärderas är vilket stöd systemen har för att övervaka ett flertal tjänster, hur god prestandan är för varje system samt hur god användbarheten i gränssnittet är. Resultatet visar att Nagios, OpenNMS samt Argus hade stöd för samtliga tjänster medan Munin inte hade stöd för nätverksenheter och Cacti endast stöd att övervaka SNMP. Det visar även att Nagios och OpenNMS generellt hade möjlighet att larma vid fler händelser samt att dessa två system var markant snabbare än Cacti och Munin. Användbarheten visade relativt stor skillnad i olika system. OpenNMS hade högst totalpoäng, men Nagios presterade något bättre i vad Sundström (2005) kallar för interaktion. Munin och Argus fick samma resultat med låg funktionalitet och högre struktur medan Cacti hade god funktionalitet och interaktion men väldigt låg struktur.
Penet, Maxime. "Robust Nonlinear Model Predictive Control based on Constrained Saddle Point Optimization : Stability Analysis and Application to Type 1 Diabetes". Phd thesis, Supélec, 2013. http://tel.archives-ouvertes.fr/tel-00968899.
Pełny tekst źródłaAzevedo, Diego Sousa de. "Otimização do código do sistema de navegação e controle de robôs móveis baseado em NMPC para embarcar em arquiteturas de baixo custo". Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/7853.
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The purpose of this study is to adapt and embed a navigation system and control of mobile robots, based on NMPC, in a low-cost board existent on the market, to provide sufficient com-putational resources so that the robot is able to converge, without losing performance, using the same horizons applied in a Laptop. The obtained results demonstrate the proposed scenario according with the experiments, proving that it is possible to use low cost boards, to a navigation system and control of mobile robots, based on NMPC, using the same predictive and control horizons applied in a Laptop.
A proposta desse trabalho é adaptar e embarcar um sistema de navegação e controle de robôs móveis, baseado em NMPC, em uma placa de baixo custo já existente no mercado, que dispo-nibilize recursos computacionais suficientes para que o Robô seja capaz de convergir, sem perda de desempenho e utilizando os mesmos horizontes aplicados em um Laptop. Os Resulta-dos obtidos demonstram todo o cenário proposto e de acordo com os experimentos realizados, comprovou-se que é possível o uso de placas de baixo custo, para controle de robôs móveis, baseado em NMPC, utilizando os mesmos horizontes de predição e controle aplicados em uma Laptop.
Hedström, Therese, i Sara Lundahl. "Evaluation of monitoring systems and processes". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-31855.
Pełny tekst źródłaMartin, Jake Joseph. "Geophysical and geological analysis of fault activity and seismic history of the Obion River Area, New Madrid Seismic Zone (NMSZ), Western Tennessee, USA". Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:103595.
Pełny tekst źródłaThe New Madrid Seismic Zone (NMSZ) is well known for producing some of the largest intra-cratonic earthquakes within the North American Plate. The common hypothesis for the geological structure within the NMSZ is that stress is released across three major faults: the Cottonwood Grove Fault, the New Madrid North Fault, and the Reelfoot Thrust Fault. Evidence exists that would suggest an alternative model of geologic deformation in the area: that stress is being released across more than these three faults. A geologic and geophysical investigation was done to investigate a hypothetical fault west of Dyersburg, TN to test the alternative multi-fault hypothesis. A seismically created sand blow was logged in close proximity to the fault projection. Weathering of the sand blow indicated that the age of the sand blow came from a seismic event prior to the 1811-1812 earthquakes. There was no evidence to confirm this sand blow was created by a hypothetical fault in close proximity. A seismic exploration of the area was done across four seismic lines, primarily mapping Quaternary-age Mississippi River flood plain deposits. These seismic surveys yielded no evidence to suggest the presence of an additional fault. Across all surveys no evidence was found to conclusively support any existing theory on fault movement in the NMSZ
Thesis (MS) — Boston College, 2014
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Earth and Environmental Sciences
López, Lorenzo Ximena. "Mapping the Expression of Cyclin Dependent Kinase Inhibitors in High-Risk Neuroblastoma Cell Lines : Dynamics on Cell-Fate Decisions on Proliferation/Cell Cycle Arrest". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278705.
Pełny tekst źródłaDålig prognos för högrisk neuroblastompatienter gör det nödvändigt att hitta nya behandlingsstrategier.Detta arbete syftar till att förstå cellcykelbeteendet hos olika högrisk neuroblastomcellinjerefter kemoterapibehandling. I denna studie kartlades uttrycket av cellcykelberoendeproteinerna, p21 och p27, i sju högrisk neuroblastomcellinjer. Alla cellinjervisade en total nedsatt tillväxt efter doxorubicinbehandling. Återväxt observerades emellertidmellan dag 6 och 15 genom bildandet av kolonier. Uttrycket av p21 och p27 mättesi alla cellinjer. Resultaten visade en uppreglering av p21 i 3 av 5 p53-muterade cellinjermedans det nedreglerades i de två cellinjerna med en p53-vildtyp. Vidare utfördes inhiberingsanalysermed användning av hämmare mot CHK1/2, p21 eller, SKP2. Resultatenär lovande då CHK1/2-hämmaren reducerade cellviabiliteten i alla testade cellinjer, medanp21-hämmaren hade en effekt i 3 av 6 testade cellinjer och SKP2 i 4 av 6 testadecellinjer. Konfluensmätning under 15 dagar visade nedsatt tillväxt efter behandling medCHK1/2-hämmaren för 3 av 6 testade cellinjer och p21-hämmare i 1 av 6 testade cellinjer.De erhållna resultaten är lovande och kan hjälpa till att hitta en ny behandlingsstrategi somförhindrar resistens och återfall i neuroblastom. Ytterligare studier behövs emellertid föratt validera effektiviteten och säkerheten för dessa lovande läkemedel hos neuroblastompatienter.
Sa, Qina. "Synthesis and Impurity Study of High Performance LiNixMnyCozO2 Cathode Materials from Lithium Ion Battery Recovery Stream". Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-dissertations/381.
Pełny tekst źródłaKozubík, Michal. "Aplikace nelineárního prediktivního řízení pro pohon se synchronním motorem". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2019. http://www.nusl.cz/ntk/nusl-400605.
Pełny tekst źródłaToyama, Mayumi. "Non-motor symptoms depending on motor severity in Japanese patients with Parkinson's disease: A multicenter cross-sectional study". Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263522.
Pełny tekst źródłaGeoffroy, Isabelle. "Nouveaux électrolytes à base de N-methyl sydnone (NMS) ou de carbonates d'alkyle dissymétriques (ACS) pour accumulateurs à ion lithium". Tours, 2000. http://www.theses.fr/2000TOUR4010.
Pełny tekst źródłaHussain, Raza. "Caractérisation multi-niveau de protéines laitières : influence de l'environnement ionique et de la température". Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0100/document.
Pełny tekst źródłaThe overall objective of this work was to investigate the mechanisms of protein-salt interactions and linkage between milk proteins powders and milk proteins dispersions (5% w/v) mainly NMC and WPI under various ranges of ionic environments (distilled water, NaCl solution and CaCl2 solution. In the first phase, we investigated the influence of the ionic environments on milk proteins powders rehydration profiles. The second phase of this study includes the characterization of milk proteins dispersions in an aqueous ionic environment regarding changes in the protein: secondary structure (ß-sheet, alpha-helix, ß-turns and unordered structures), size, morphological features and surface hydrophobicity by using FTIR, TEM, and DLS with other complimentary techniques. In the last part, the functionality of whey proteins was studied by the combined effect of heat and different ratios of salts. For this purpose, the study was exclusively focalized in an aqueous ionic medium composed of NaCl (0.75-3%) at different temperatures (30-90°C). The results obtained from the first part showed two distinct rehydration behaviors depending on the salts type and concentration. For the NMC dispersions under salt increase, spherical micelles with an average size around 150 nm disintegrated in sub-micelles around 20-30 nm and more or less aggregated were observed by DLS and TEM. WPI dispersions in water were composed of well separated proteins by a spherical shape with two populations around 6 and 70 nm. Salt increase resulted in an aggregation of the proteins and the formation of denser aggregates. Moreover, a combined salt/heat resulted showed a stabilizing effect on the secondary structural elements of both Amide I and III bands and higher denaturation temperatures observed by FTIR and µDSC respectively. A size and morphological investigation showed a transition from spherical/compact protein aggregates to linear ones. Finally, this work demonstrated that whey protein functional properties depend on both salt and how heat treatment is applied
Merten, André. "Neues Design von Langpfad-DOAS-Instrumenten basierend auf Faseroptiken und Anwendungen der Untersuchung der urbanen Atmosphäre". [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-84994.
Pełny tekst źródłaFarhat, Douaa. "Etude d'électrolytes à base de dinitriles aliphatiques pour des batteries Li-ion". Thesis, Tours, 2017. http://www.theses.fr/2017TOUR4035/document.
Pełny tekst źródłaDue to their low vapor pressure as well as their electrochemical (5~6 V) and thermal stability, dinitriles N≡C-(CH2)n-C≡N are proposed as alternative electrolyte solvents to alkyl carbonates commonly used in Li- ion batteries. The objective of this thesis is to study the physico-chemical behavior of these alternative electrolytes (viscosity, ionic conductivity, thermal behavior, volumetric properties, etc.) and their use in Li-ion batteries. Two battery systems are studied using a lamellar oxide (LiNi1/3Mn1/3Co1/3O2) as positive electrode associated with graphite or Li4Ti5O12 as negative electrodes. The cyclability of electrodes in half-cell and full-cell is studied according to the electrolyte composition and the nature of the dinitrile used. Characterization techniques like: electrochemical impedance spectroscopy, electron microscopy and X-Ray photoelectrons spectroscopy, are used to study the passivation of the negative electrode and the stability of the positive electrode. The effect of adding specific solid electrolyte interphase (SEI) builders is investigated and their efficiency is hence clearly demonstrated
Peterová, Soňa. "Nové gelové elektrolyty na bázi kopolymerů pro elektrochemické zdroje proudu". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413230.
Pełny tekst źródłaHoover, Nathan. "Succession of an Upland Oak/Hickory Forest in the Central Hardwood Region". OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2352.
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