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Artykuły w czasopismach na temat "Nie 08/15"
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Zhang, Shengzhe, Sung Ho Lee, Litong Nie, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M. Lien, Junjie Chen i Jae-Il Park. "Abstract P5-08-15: Overcoming mTOR inhibitor resistance by targeting the lysosomal deregulation". Cancer Research 82, nr 4_Supplement (15.02.2022): P5–08–15—P5–08–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-08-15.
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Abstract Increasing evidence suggests that the deregulated lysosomes contribute to tumorigenesis and therapeutic resistance. However, its underlying mechanisms remain elusive. Here, we identify transmembrane protein 9 (TMEM9) as a regulator involved in lysosomal metabolism and mammary tumorigenesis. The TMEM9 gene is markedly amplified in breast cancer, correlated with its transcriptional upregulation. We uncovered that Tmem9 knock-out inhibited mammary tumorigenesis in genetically engineered mouse models. Consistently, TMEM9 depletion suppressed the proliferation of breast cancer cells highly expressing TMEM9. Conversely, the ectopic expression of TMEM9 in TMEM9 low breast cancer cells promoted cell proliferation. The lysosome purification and proteomics approach showed that TMEM9 physically and functionally interacts with LAMTOR4, a subunit of the Ragulator complex, to hyperactivate mTOR signaling in breast cancer. Moreover, the combination of TMEM9-v-ATPase inhibitors with mTOR inhibitors exhibited the synergistic growth inhibition of breast cancer cells in vitro and in vivo. Our results reveal that the TMEM9-v-ATPase axis is not only a biomarker for resistance to mTOR inhibition therapy but also a molecular target overcoming mTOR inhibitor resistance. Citation Format: Shengzhe Zhang, Sung Ho Lee, Litong Nie, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M Lien, Junjie Chen, Jae-Il Park. Overcoming mTOR inhibitor resistance by targeting the lysosomal deregulation [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-08-15.
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Febin Edwin, Moshieve. "Adult ADHD outcome audit based on NICE guidelines". Advances in Mental Health and Intellectual Disabilities 8, nr 5 (26.08.2014): 331–37. http://dx.doi.org/10.1108/amhid-08-2013-0054.
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Purpose – Adult ADHD is a neuro-developmental disorder. The current prevalence of ADHD in adults is around 1.9-4 per cent. The service for adults with ADHD based on NICE guideline recommendation. Hence, the author decides to audit the Adult ADHD case loads against the gold standard set by the NICE. The paper aims to discuss these issues. Design/methodology/approach – The study was based on a retrospective analysis and collection of data from electronic patient records for a duration of five months between October 2011 and February 2012. The data findings were matched against the NICE standards. There were 15 standards identified. On top of that we used six service outcome questions to improve the Quality of the service provided. Findings – As the service outcomes were set for 100 per cent, the performance fell short in few areas. The service managed to achieve roughly 80-95 per cent in areas such as medication monitoring, transition service and care plan with shared care guidelines for prescription in primary care. The service under performed in areas on non-pharmacological interventions such as cognitive-behavioural therapy (CBT). The service continues to provide a exceptional service for adults with intellectual disability and ADHD. Research limitations/implications – The research was limited by information and recall bias due to the retrospective nature of data analysis. There was also over representation of the numbers in co-morbid cases due to more than two diagnosis. Practical implications – The paper outlines the regional outcome of the audit. However the findings have wider implications. For example the prevalence rate is more common in males than females. CBT is an important resource in the management of ADHD in adults. Priority and importance need to be given for providing a service for CBT in adults with ADHD. Social implications – The cost of sickness and non-employment due to ADHD is significantly high. Treating this complex group with medications and CBT improves the outcome and get them back in employment and reduce recidivism rates in offenders. Originality/value – The author feels the adult ADHD service audit has huge service implications. Currently it is a controversial diagnosis significantly under-resourced. The outcome survey had highlighted the areas of need as a neurodevelopmental disorder.
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Zavyalova, Nataliya Alekseevna. "Participation in nature and the human world as the basis of concepts within the framework of the socio-cultural space of China. Concepts "Water" and "Sky"". Uchenyy Sovet (Academic Council), nr 11 (10.10.2021): 870–81. http://dx.doi.org/10.33920/nik-02-2111-08.
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Chinese cultural concepts containing participation in the natural world are distributed as follows. Concept "Nature" — 2 CCF. Concept "Peace" — 3 CCF. Concept "Earth" — 13 CCF. Concept "Water Resources" — 24 CCF. Concept "Sky" - 25 CCF. Concept "Void, hole" — 7 CCF. Concept "Mountains" — 15 CCF. Concept "Precious stones" — 6 CCF. Concept "Sides of the World" —5 CCF. Concept "Way" - 7 CCF. Concept "Color" — 23 CCF. Concept "Shadow" - 5 CCF. Concept “Time. Change of day and night" — 7 CCF. Concept "Seasons" — 8 CCF. Concept "Temperature" — 7 CCF. Concept "Wind" — 29 CCF. Concept "Sound" — 2 CCF. Concept "Fire" — 9 CCF. Concept "Plants" — 35 CCF. Concept "Animals" — 65 CCF. Concept "Birds" — 17 CCF. Concept "Insects, fish, reptiles" — 14 CCF. Large numerical indicators of the concepts "Water resources", "Earth", "Sky", "Color", "Animals" and "Insects, fish, reptiles" are formed by the principle of adding several smaller sub-concepts at once (varieties of water resources, varieties of celestial bodies, various color shades, species of animals, plants, fish and reptiles).
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Healy, Soracha, i Radhika Lakhani. "Antipsychotic Optimisation on an Adult Acute Inpatient Ward: A Retrospective Audit". BJPsych Open 8, S1 (czerwiec 2022): S156. http://dx.doi.org/10.1192/bjo.2022.442.
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AimsAntipsychotic prescribing in acute inpatient settings is an integral part of patient care. The aim of this audit was to review optimisation of antipsychotics on an acute adult inpatient ward in South West London and St George's NHS Mental Health Trust (SWLSTG). It was ascertained how antipsychotic prescribing on an acute ward meets NICE standards, including duration of antipsychotic use prior to medication change. Furthermore, communication of medication changes was reviewed in the context of the paramount importance of collaborative decision-making in aiding adherence. NICE recommends a 4–6 week trial of antipsychotic medication at optimal dosage. However, it was hypothesised this may vary with side-effects, adherence and risk management in the inpatient environment. To establish the relationship between these factors, data were extracted regarding antipsychotic counselling, baseline physical health investigations, antipsychotic choice, dosage and duration, side-effects and treatment response.MethodsRetrospective data analysis was conducted for patients on an acute adult inpatient ward in SWLSTG. Data extracted from Rio clinical record system and EPMA prescribing software were analysed in Excel. The inclusion criteria were patients admitted or transferred to a 20-bed acute mixed adult ward from 04/08/21 to 04/11/21 with a diagnosis of schizoaffective disorder, schizophrenia, bipolar affective disorder or nonorganic psychosis. This included patients being initiated or continued on antipsychotic medication. From 71 patients, 33 met inclusion criteria. Data were extracted regarding duration of treatment prior to changes in treatment, counselling and pre-treatment investigations. Furthermore, simple statistical analyses were carried out.ResultsThe most commonly initiated antipsychotics on admission were olanzapine (33%), quetiapine (21%), risperidone (15%) and zuclopenthixol decanoate (15%). In those requiring change in antipsychotic regime, mean duration from the start of treatment as inpatient to first change was 11.6 days, time between first and second change 13.8 days, and between second and third change 16.0 days.The data showed in the majority (84.6%) antipsychotics were changed or up-titrated due to inadequate response. Out of the remainder 9.6% were changed due to intolerable side effects and 5.8% due to adherence concerns. In 73% of cases counselling was attempted regarding initial medication changes.ConclusionAntipsychotic therapy was altered more quickly than advised by NICE guidance in the acute inpatient setting evaluated. This can be explained by increased risk, need for intensive management and individual clinical factors including side effects and adherence. Collaborative decision making could be enhanced by ensuring that counselling is attempted for every patient.
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Wen, Jianyun, Yuelin He, Xiaoxiao Xu, Libai Chen, Xuedong Wu, Xiaoqin Feng, Chunfu Li, Xuan Liu i Fuyu Pei. "Post-Transplant Cyclophosphamide Improved Outcomes of HLA Mismatched Hematopoietic Stem Cell Transplantation in Children with β-Thalassemia Major". Blood 134, Supplement_1 (13.11.2019): 801. http://dx.doi.org/10.1182/blood-2019-130038.
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Background:Hematopoietic stem cell transplantation(HSCT) is currently the only treatment shown to provide an effective, definitive cure for β-thalassemia major (TM). All over the world a major constraint is the lack of access to this therapy related to the lack of a suitable donor. Matched related donors are generally available only for a third of patients with TM.The need for alternative donors has therefore been explored in several ways-partially mismatched related donors, related haploidentical transplants,and matched or mismatched unrelated donors.Persisting concerns regarding high rejection rates and graft versus host disease (GVHD) need to be addressed through the evaluation of novel protocols in current and future studies.The effect of alloreactive clone destruction in post-transplant cyclophosphamide (Cy, PTCy) transplant resulted in low GVHD and high relapse but nice immuno-recovery and immuno-tolerance by keeping antivirus and regulatory T cells. Therefore, we developed a novel protocol for TM patients received HSCT form HLA mismatched donors. Patients and methods:Twenty patients received HSCT form HLA mismatched donors between May 2014 and May 2017,with median follow-up time of 38 months (range: 2-65months).The median age at transplant was 8 years (rang:4-13years). Of them, 15 patients received unrelated- donor peripheral blood stem cell transplant(UD-PBSCT) consisted of 13 HLA 9/10(HLA-A loci,DRB loci and DRQ loci mismatched are 8,2and2,respectively) and 2 HLA 8/10(1 HLA-A and DRB loci mismatched and 2 HLA-DRB and DRQ loci mismatched), another 5 patients received HLA 9/10 related-donor peripheral blood stem cell transplant (RD- PBSCT) consisted of 3 HLA-A loci and 2 HLA-DRB loci mismatched.Among them,3 patients received adopting bone marrow(BM) and/or unrelated-donor cord blood(UD-CB). Conditioning regimen included Thymoglobuline on day -10 to -8, Cy on day-7, Busulfan on day-6 to -4, Fludarabine on day-6 to -2 and Thiotepa on day-3. GVHD prophylaxis consisted of Cy on day+3 to +4, Mycophenolate mofetil and Tacrolimus from day+6. BM or UCB was infused on day+1.GVHD prophylaxis consisted of Cy on day+3 to+4, Mycophenolate mofetil and Tacrolimus from day+5. Results:The median infused total nucleated cell (TNC) dose was 24.8×108/kg (range: 9.0-40.2×108/kg). The median dose of infused CD34+ cells was 13.88×106/kg (range 2.89-38.76× 106/kg). All twenty patients had a successful engraftment with > 95% donor-derived cells by day 30 after transplantation.The median time to neutrophil recovery was 21 days (range 16-36days). The platelet and hemoglobin engraftment times were 14 days (range10-65days) and 15 days (range 8-48days), respectively.The cumulative incidences of grades Ⅱ-III acute GVHD (aGVHD) was 10.0% (2/20 patients).No patient developed grade IV aGVHD after transplantation. No extensive or limited chronic GVHD(cGVHD) was diagnosed among any patients in the group.The incidences of CMV and EBV antigenmia were 10.0% (2/20) and 0%(0/20), respectively. All of the 20 patients were alive without TM, and overall survive(OS)and thalassemia free survive (TFS) were 100% and 100%, respectively.We also compared the outcomes of PTCy protocol with fifty-two patients with β-TM received one or two locis HLA mismatched HSCT by use of the NF-08-TM protocol(see Li et al., Blood 2012).OS and TFS were higher in the PTCy group(100%vs.90.4%,p<0.05 and 100%vs.86.5%,p<0.05, respectively;).No patients in the PT Cy protocol group had GR, whereas 2 patients had GR in the NF-08-TM protocol group (0.00% vs.3.84%,p<0.05,respectively ).Of the 50 patients who had a successful in the NF-08-TM protocol group engraftment,aGVHD occurred in 8 patients and the incidence of grade Ⅱ-III and IV aGVHD were 6% and 6% (3/50 and 3/50 patients), respectively. One pulmonary cGVHD was diagnosed in the NF-08-TM protocol group and one patient died of IV GVHD.Compared to the NF-08-TM protocol group, patients in PTCy protocol group had a lower incidence of aGVHD(10.00% vs.16.00%,p<0.05), especially IV aGVHD (0.00% vs.6.00%, p<0.05). Conclusion: PTCy protocol leaded to 100% OS and TFS with low GR and GVHD rate compared with the NF-08-TM protocol in patients with β-TM who received HSCT form HLA mismatched donors. A large-cohort study with extending follow-up time should be developed in the future. Disclosures No relevant conflicts of interest to declare.
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Jha, Khushboo, Indra Bir Mishra, Sonu Verma i K. Bharathi. "Management of IUGR with Pregnancy induced hypertension by Ayurveda Regimen: A Case Report". Healer 2, nr 02 (31.07.2021): 117–23. http://dx.doi.org/10.51649/healer.67.
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A Christain women aged 29 yrs visited OPD of NIA demmed to be university on (24/04/2021) with the complaint of Amenorhoea 9 months (G2P1A0L1) associated with itching on upper and lower extremities since 3 month. She also complaints of swelling in her leg, which resembles us towards the pedal edema. She also complaints of severe hyperacidity, chest pain on and off, occasional headache since 10 days in the first visit. Her L.M.P.-15/08/2020, E.D.D: 22/05/21 and P.O.G.-35 weeks 6 days. Diagnostic assessment was done by USG and Laboratory investigations and Clinical examination. The findings of USG revealed Single live intrauterine pregnancy of 34 weeks 6 days with mild IUGR, mild oligohydramnios. Loop of cord around neck, Normal fetoplacental blood flow pattern. Placenta was Grade III With calcified. In Ayurvedic classics lakshanas of Garbhakshaya, Garbhasosha, Vatabhipanna Garbha are near to signs and symptoms of IUGR. Ksheera vasti was planned along with it oral medications Avipatikar Churna, Pittantak Churna , Kapardika Bhasma, Shankha Bhasma and Gokshura Churna in combination, Phalasarpi, Swarna Vasanta malati rasa and Punarnavastak Kwatha. Patient got relief from Severe oedema. The other complaints like severe hyperacidity, Headache were relieved. Then after her B.P. was 110/70 throughout. Fetal movements were good after Vasti procedure due to which patient felt well relaxed. Patient got her labor pain and delivered on 8th May with the weight 2.2kg male child at Government Hospital. The delivery was uneventful. After ksheeravasti there was increase in weight of the baby around 118gms. Just in six days Vasti provided such a enormous change.
Keywords: IUGR, Pregnancy Induced hypertension, Ksheera Vasti, Punarnavastak kwatha, Gokshura Churna
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Yusuf, J. K., J. O. Cheikyula i P. A. Annune. "Growth performance and nutrient utilisation of Clarias gariepinus fed on sweet orange peels (Citrus sinensis) as carbohydrate source". Global Journal of Fisheries Science 4, nr 3 (30.10.2022): 23–33. http://dx.doi.org/10.31248/gjfs2022.035.
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The effect of substitution of maize meal with orange peel in the diet of Clarias gariepinus was investigated. Proximate composition, anti-nutritional content of differently processed orange peels and their effects on the growth of Clarias gariepinus were investigated. Soaked sweet orange peel meal was used in the formulation of the experimental diet and replaced maize at 25, 50, 75, and 100% inclusions respectively while the control diet was at 0% SOPMs replacement. The experiment consists of five treatments (1, 2, 3, 4 and 5) with two replicates in a completely randomized design (CRD). Two feeding trials lasted for a period of 8 weeks (56 days) and was carried out in a concrete experimental pond measuring 2 m x 1 m x 0.5 m. Two hundred Clarias gariepinus fingerlings, 10 g average weight were randomly distributed at 40 fish per replicate. Growth responses were checked and recorded weekly with a sensitive weighing balance (Mettler 5000) to the nearest grams after which feed quantity was adjusted. Fish were fed experimental diet twice daily (08:00 am and 05:00 pm) at 5% body weight, pond water was changed weekly during weight recording and the water quality parameters were monitored. The results of the proximate analysis of orange peel meals under different processing methods indicated that moisture content was highest in sundried peels (6.74) and lowest in cold-soaked peels (5.8%). Lipid content was highest in boiled peels (8.47) and lowest in fermented peels (7.71%). Protein content was highest in boiled peels (7.43) and lowest in sundried peels (6.40%). The highest NFE was recorded in the sundried peels (60.90) while lowest NFE value was recorded in the fermented (54.38). The anti-nutritional factors determined from the various processing method showed that boiling was more effective in reducing tannin (46.4% reduction), phytic acid (46.5% reduction), oxalate (54% reduction) and was least effective in reducing saponin (20% reduction). Fermentation was least effective in ANF reduction, tannin (21%) and phytic acid (15%); cold-soaking was more effective in saponin reduction (46.5%). Result obtained revealed that there was no adverse effects on the growth performance of the fish fed orange peel meals at 50% inclusion, thus sweet orange peel meals can replace maize up to 50% level of inclusion in the diet of Clarias gariepinus fingerlings without adverse effect with a corresponding SGR of (2.64±0.00). Apparent net protein utilization differed among the treatments (p<0.05).
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Pudashini, B. J., M. S. Shahid i K. T. Natsuaki. "First Report of Bean common mosaic necrosis virus (BCMNV) Infecting Sweet Bean in Nepal". Plant Disease 97, nr 2 (luty 2013): 290. http://dx.doi.org/10.1094/pdis-08-12-0741-pdn.
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Bean common mosaic necrosis virus (BCMNV; Family Potyviridae, genus Potyvirus) infects legume crops in many regions of the world. It is transmitted in a non-persistent manner by aphids and is also readily seed-transmitted (3). Sweet bean (Lablab purpureus L.) is an important legume crop widely cultivated in Nepal. In December 2010, sweet bean plants with mottle and leaf deformation, severe mosaic, necrosis, malformation of leaves and pods, downward curling of leaves, and reduction in leaf size were observed in 20 different fields with 60 to 70% incidence in Nepal. ELISA was performed by using a universal Potyvirus antiserum test kit (Agdia Inc., Elkhart, IN) on 18 symptomatic leaf samples collected from five different locations (Malepatan, Lake side Fewataal, Darai village, Pakaudi, and Rampur) of Pokhara and Chitwan provinces and 15 out of 18 samples had a positive reaction. Filamentous shaped particles similar to Potyvirus of about 690 to 720 × 10 to 12 nm were observed by electron microscopy confirming the ELISA results. To further characterize the viral isolate(s), primary leaves of some legume crops (Phaseolus vulgaris, Glycine max, Psophocarpus tetragonolobus, Vigna unguiculata, and Arachis hypogeae) and sweet bean were mechanically inoculated with sap prepared from the same leaves used for ELISA. Phaseolus vulgaris cv. Aron and G. max cv. Togenkyou plants showed necrotic spots on inoculated leaves followed by systemic necrosis and death. Psophocarpus tetragonolobus and V. unguiculata showed systemic mosaic symptoms, while A. hypogeae and sweet bean cv. Shirobhanafuji-mame showed necrotic spots and restricted veinal necrosis. Chenopodium amaranticolor and C. quinoa also showed chlorotic local lesions on inoculated leaves. For molecular identification, total RNA was isolated from 18 symptomatic plants using Trizol Reagent (Invitrogen, Carlsbad, CA). Reverse transcription (RT)-PCR was carried out using universal primer pairs that amplify the NIb-coat protein (CP) region including the 3′-untranslated regions (UTRs) of Potyvirus as described previously (1). An amplicon of approximately 1.7 kb was amplified and cloned using the pGEM-T Easy vector system (Promega, Fitchburg, WI). Two clones (GenBank Accession Nos. AB734777 and AB735585) with 99.9% sequence identity were selected for further analysis. These clones shared a maximum of 94% amino acid identity and 90% nucleotide identity in the CP region, and 93% nucleotide homology in the 3′-UTR with the ‘TN1’ (GenBank Accession No. U37076) strain of BCMNV isolated from Phaseolus vulgaris (2). These comparisons indicated that the viral isolates belong to the BCMNV species and are the causal agent of mosaic and necrosis observed on the sweet bean plants in Nepal. To our knowledge, this is the first report of BCMNV in Nepal and also the first report of BCMNV from sweet bean. References: (1) P. H. Berger et al. Arch. Virol. 142:1979, 1997. (2) J. Chen et al. Arch. Virol. 146:757, 2001. (3) Z. Hongying et al. Arch. Virol. 147:1257, 2002.
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Biswas, C., P. Dey, A. Bera, M. Kumar i S. Satpathy. "First Report of a 16SrV-C Phytoplasma Causing Little Leaf and Bunchy Top of Tossa Jute (Corchorus olitorius) in India". Plant Disease 98, nr 4 (kwiecień 2014): 565. http://dx.doi.org/10.1094/pdis-08-13-0826-pdn.
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Jute is the most important phloem fiber crop of the world, and is mainly grown in the South East Asian countries of India, Bangladesh, Nepal, China, Indonesia, Thailand, and Myanmar, and few South American countries. The fiber is used in making sacks, ropes, bags, carpets, shoes, geo-textiles, and home decorations. There are two kinds of jute: tossa jute (Corchorus olitorius L.) and white jute (C. capsularis). In June 2012, symptoms suggestive of phytoplasma infection (little leaf and bunchy top) were noticed on tossa jute in different experimental fields of the CRIJAF research farm, Barrackpore, India, and the incidence of the disease varied from 5 to 20%. The infected plants showed profuse lateral branching with a bushy appearance. In many plants, branching at the apical portion developed a bunchy top symptom with tufts of smaller leaves. Leafy stem was also common in many plants with main stems covered with numerous little leaves. Total DNA was extracted from leaf midveins of 15 symptomatic and 5 asymptomatic plants by using an improved salt concentration and simple sodium acetate CTAB method (1). PCR was carried out with universal P1/P7 primer set followed by nested primer pair R16F2n/R16R2 (3), resulting in DNA amplicons that were 1.8 kb and 1.2 kb, respectively, in all symptomatic samples tested. Phytoplasma was not detected in symptomless samples. The five purified nested products were cloned in a pGEM-T Easy vector (Promega) and sequenced. One of the sequences that proved to be identical was deposited in GenBank (Accession No. KF501045). The consensus sequence was analyzed by NCBI BLAST and found to share 99% similarity with the 16Sr DNA sequence of the alder yellows phytoplasma reference strain (GenBank Accession No. AY028789), which belongs to the 16SrV group. The phylogenetic tree based on the 16SrDNA sequence of phytoplasmas belonging to group 16SrV and other distinct phytoplasma groups also showed that the phytoplasma clustered with members of subgroup 16SrV (4). Subsequently, in silico RFLP analysis of the nested PCR product with the pDRAW32 program using AluI and TruI restriction site used for 16SrV subgroups A, B, C, D, and E indicated that the 16SrV Corchorus strain belonged to subgroup C. RFLP patterns from all symptomatic C. olitorius samples were identical to the 16SrV-C pattern (2). The vector species transmitting the concerned phytoplasma in C. olitorius still needs to be identified. The leaf hopper, Amrasca biguttula biguttula, may be a potential vector as it is often noticed in jute fields. To the best of our knowledge, this is the first report of 16SrV-C phytoplasma associated with tossa jute (C. olitorius) in India. Initiative has to be taken to manage this disease; otherwise, branching of the main stems would badly affect the fiber quality as well as yield. References: (1) C. Biswas et al. Lett. Appl. Microbiol. 56:105, 2012. (2) B. Duduk et al. J. Phytopathology 152:575, 2004. (3) I. M. Lee et al. Int. J. Syst. Evol. Microbiol. 54:337, 2004. (4) N. Saitou and M. Nei. Mol. Biol. Evol. 4:406, 1987.
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Bertolazzi, Luana Gaino, i Marcia Galan Perroca. "Impact of interruptions on the duration of nursing interventions: A study in a chemotherapy unit". Revista da Escola de Enfermagem da USP 54 (2020). http://dx.doi.org/10.1590/s1980-220x2018047503551.
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Abstract Objective: To investigate interruptions during nursing interventions in a chemotherapy unit (sources and causes); measure their frequency, duration and the total elapsed time to complete the interventions. Method: This is an observational analytical study performed using a digital stopwatch. It was conducted in a teaching hospital between 2015/2016. The interventions performed and their interruptions were mapped and classified according to the Nursing Interventions Classifications (NIC) taxonomy. Results: There were 492 interruptions recorded in the 107 hours observed, especially in indirect care interventions. They were mainly caused by nursing professionals (n = 289; 57.3%) to supply materials (n = 65; 12.8%) and exchange care information (n = 65; 12.8%). The duration of interruptions ranged from 0:08 to 9:09 (average 1:15; SD 1:03) minutes. On average, interventions took 2:16 (SD 0:27) minutes to complete without interruption; however, the average was 5:59 (SD 3:01) minutes when interrupted. Conclusion: The interruptions were constant during the nursing work in the chemotherapy unit, including during the preparation and administration of medications, and increased the time to complete the interventions by an average of 163.9%.
Książki na temat "Nie 08/15"
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Nie 08/15 - Finanzvertrieb neu gedacht: Das einzige E-Book, dass du zum Thema Strukturvertrieb lesen musst. KÖNIGSWEGE GmbH, 2024.
Znajdź pełny tekst źródłaCzęści książek na temat "Nie 08/15"
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Czejarek, Karol. "Hans Hellmut Kirst, autor nie tylko 08/15". W Pamięć o przeszłości w prywatnych narracjach i historiografii. Warsaw University Press, 2017. http://dx.doi.org/10.31338/uw.9788323530800.pp.250-260.
Pełny tekst źródłaStreszczenia konferencji na temat "Nie 08/15"
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Graor, R., J. Young, B. Beven, N. Hertzer, L. Krajewski, P. O'Hara, J. Olin i W. Ruschhaupt. "rt-PA THROMBOLYSIS VERSUS SURGICAL THROMBECTOMY OF PERIPHERAL BYPASS GRAFTS:A COMPARATIVE TRIAL". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643888.
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Twenty-nine of 33 patients (88%) with thrombosed lower extremity bypass grafts had angiographic and clinical successful lysis of graft thrombi with rt-PA. Of the successful group, 18 were saphenous vein grafts and 11 PTFE grafts in the femoropopliteal-tibial position. Following lysis, 76% required a secondary procedure (2 PTA, 20 surgical repair and 7 required anticoagulation) to maintain patency. A matched cohort of patients with bypass grafts who had surgical thrombectomy were compared to the rt-PA successfully treated grafts and analyzed for duration of patency after opening and limb salvage. The Kaplan-Meier curve compared both treatment groups and demonstrated improved graft survival in the rt-PA treated group (p=.01) (median graft survival rt-PA 195 days, surgery 30 days). Limb salvage was marginally significant (p=.064) in favor of the rt-PA treatment group. Single and multi-variant risk factor analysis found smoking and age of the graft adversely affected patency (p=.05 and p=.08 respectively). Graft type, age of the patient, diabetes mellitus, and high blood pressure were not significant factors (p> .15).Systemic fibrinolysis was identified to varying degrees. Mean decreases in the fibrinolytic constituents include: 59% decrease in clottable fibrinogen, 18% decrease in sulfite fibrinogen, 78% decrease in alpha-2 antiplasmin and varying degrees of increases in DDIMER, B-Beta1-42 and B-Beta15-42 coincident with the constituent changes. Complications were unrelated to constituent changes. One patient had major bleeding secondary to graft anastomosis disruption.Thrombolysis with rt-PA is an effective and more durable adjunct treatment option for thrombosed bypass grafts, especially when combined with PTA or surgical repairto maintain patency.
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Athanatou, Maria, i Elena Theodorou. "International Society of Experimental Linguistics ExLing 2021 12th International Conference of Experimental Linguistics 11 - 13 October 2021 Athens, Greece Menu Athens: 15:46:27 Brussels: 14:46:27 GMT: 13:46:27 London: 13:46:27 New York: 08:46:27 Tokyo: 22:46:27 ExLing 2020 (58) How do writing systems shape reading and reading acquisition? Kathy Rastle DOI: 10.36505/ExLing-2020/11/0001/000416 Published in ExLing 2020 Children’s syntax: a parametric approach William Snyder DOI: 10.36505/ExLing-2020/11/0002/000417 Published in ExLing 2020 A neurophonetic perspective on articulation planning Wolfram Ziegler DOI: 10.36505/ExLing-2020/11/0003/000418 Published in ExLing 2020 Masked priming in picture naming and lexical selection Manal Alharbi DOI: 10.36505/ExLing-2020/11/0004/000419 Published in ExLing 2020 Syllable rate vs. segment rate in perceived speech rate Yahya Aldholmi DOI: 10.36505/ExLing-2020/11/0005/000420 Published in ExLing 2020 Properties of nominal stress grammar in Greek Vasiliki Apostolouda DOI: 10.36505/ExLing-2020/11/0006/000421 Published in ExLing 2020 Eliciting focus-sensitive why-questions in Japanese Kodai Aramaki, Kanako Ikeda, Kyoko Yamakoshi, Tomohiro Fujii DOI: 10.36505/ExLing-2020/11/0007/000422 Published in ExLing 2020 Comprehension of verb directionality in LIS and LSF Valentina Aristodemo, Beatrice Giustolisi, Carlo Cecchetto, Caterina Donati DOI: 10.36505/ExLing-2020/11/0008/000423 Published in ExLing 2020 Complex syntax intervention for Developmental Language Impairment". W 11th International Conference of Experimental Linguistics. ExLing Society, 2020. http://dx.doi.org/10.36505/exling-2020/11/0009/000424.
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Intervention for children with Developmental Language Disorder appears to be beneficial and contributes to sustainable linguistic gains. This paper reports on a pilot intervention study carried out in Cyprus that examined the efficacy of language treatment targeting complex syntactic structures. Language skills of a nine-year old girl with DLD are described at two time points, before and after intervention. The child received therapy sessions based on MetaTaal therapy, and relative clauses were the targeted syntactic structures. Post-intervention measurements showed marginal improvement in relative clauses production and comprehension. Improvements observed in Complex Sentence Repetition Task and this might imply that the grammatical structures have emerged.
Raporty organizacyjne na temat "Nie 08/15"
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Turnquist, Michael. PR460-223602-R01 Response to Corrosion Intersecting the Longitudinal Seam in Liquid Pipelines. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), czerwiec 2024. http://dx.doi.org/10.55274/r0000069.
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The primary objectives of project EC-02-13 "Response to Corrosion Interacting with the Longitudinal Seam in Liquid Pipelines" are to clarify what analysis methodologies are appropriate to assess corrosion intersecting a pipeline longitudinal seam weld (LSW) and to develop recommended guidelines to effectively manage these types of features. The overall project scope included execution of destructive testing of corrosion features intersecting an LSW, material property testing of LSWs produced by multiple manufacturing methods, detailed engineering analysis, and a literature review of all past relevant research. This project is funded by the Crack Management Strategic Research Priority (SRP) and is being executed in parallel with sibling projects EC-02-12 "Evaluation of Selective Seam Weld Corrosion Susceptibility," NDE-4-13 "Selective Seam Weld Corrosion Detection with In-line Inspection Technologies," IM-3-03 "Comprehensive Review and Assessment Guidelines for SSWC," IM-1-08 "Pragmatic Application of MegaRule RIN 1 - 192.712 Toughness Values," and NDE-2-15 "SSWC Identification, Sizing, and Measuring Grooving Ratio In the Ditch."