Artykuły w czasopismach na temat „Natural product”

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1

Karageorgis, George, Daniel J. Foley, Luca Laraia, Susanne Brakmann i Herbert Waldmann. "Pseudo Natural Products—Chemical Evolution of Natural Product Structure". Angewandte Chemie International Edition 60, nr 29 (23.03.2021): 15705–23. http://dx.doi.org/10.1002/anie.202016575.

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Karageorgis, George, Daniel J. Foley, Luca Laraia, Susanne Brakmann i Herbert Waldmann. "Pseudo Natural Products—Chemical Evolution of Natural Product Structure". Angewandte Chemie 133, nr 29 (23.03.2021): 15837–55. http://dx.doi.org/10.1002/ange.202016575.

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Abel, Ulrich, Corinna Koch, Michael Speitling i Friedrich G. Hansske. "Modern methods to produce natural-product libraries". Current Opinion in Chemical Biology 6, nr 4 (sierpień 2002): 453–58. http://dx.doi.org/10.1016/s1367-5931(02)00338-1.

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Wang, Junyang, Jens Nielsen i Zihe Liu. "Synthetic Biology Advanced Natural Product Discovery". Metabolites 11, nr 11 (17.11.2021): 785. http://dx.doi.org/10.3390/metabo11110785.

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A wide variety of bacteria, fungi and plants can produce bioactive secondary metabolites, which are often referred to as natural products. With the rapid development of DNA sequencing technology and bioinformatics, a large number of putative biosynthetic gene clusters have been reported. However, only a limited number of natural products have been discovered, as most biosynthetic gene clusters are not expressed or are expressed at extremely low levels under conventional laboratory conditions. With the rapid development of synthetic biology, advanced genome mining and engineering strategies have been reported and they provide new opportunities for discovery of natural products. This review discusses advances in recent years that can accelerate the design, build, test, and learn (DBTL) cycle of natural product discovery, and prospects trends and key challenges for future research directions.
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Lipparini, Paolo. "An Infinite Natural Product". Annales Mathematicae Silesianae 32, nr 1 (1.09.2018): 247–62. http://dx.doi.org/10.1515/amsil-2017-0013.

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Abstract We study a countably infinite iteration of the natural product between ordinals.We present an “effective” way to compute this countable natural product; in the non trivial cases the result depends only on the natural sum of the degrees of the factors, where the degree of a nonzero ordinal is the largest exponent in its Cantor normal form representation. Thus we are able to lift former results about infinitary sums to infinitary products. Finally, we provide an order-theoretical characterization of the infinite natural product; this characterization merges in a nontrivial way a theorem by Carruth describing the natural product of two ordinals and a known description of the ordinal product of a possibly infinite sequence of ordinals.
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Gademann, Karl. "Natural Product Hybrids". CHIMIA International Journal for Chemistry 60, nr 12 (20.12.2006): 841–45. http://dx.doi.org/10.2533/chimia.2006.841.

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Wainwright, M. "Natural Product Photoantimicrobials". Current Bioactive Compounds 3, nr 4 (1.12.2007): 252–61. http://dx.doi.org/10.2174/157340707783220202.

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Wackett, Lawrence P. "Natural product databases". Microbial Biotechnology 11, nr 4 (21.06.2018): 797–98. http://dx.doi.org/10.1111/1751-7915.13295.

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9

Kersten, Roland D., i Pieter C. Dorrestein. "Natural product nitrosation". Nature Chemical Biology 6, nr 9 (wrzesień 2010): 636–37. http://dx.doi.org/10.1038/nchembio.425.

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10

Sticher, Otto. "Natural product isolation". Natural Product Reports 25, nr 3 (2008): 517. http://dx.doi.org/10.1039/b700306b.

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Mackowiak, Elaine D. "Natural Product Education". American Journal of Pharmaceutical Education 67, nr 1 (wrzesień 2003): 6. http://dx.doi.org/10.5688/aj670106.

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12

Mann, John. "Natural product chemistry". Phytochemistry 47, nr 3 (luty 1998): 479–80. http://dx.doi.org/10.1016/s0031-9422(97)85680-4.

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13

Nash, Robert J. "Natural product biosynthesis". New Phytologist 155, nr 1 (lipiec 2002): 7. http://dx.doi.org/10.1046/j.1469-8137.2002.00449_4.x.

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14

Swain, T. "Natural product chemistry". Biochemical Systematics and Ecology 16, nr 3 (kwiecień 1988): 365. http://dx.doi.org/10.1016/0305-1978(88)90025-7.

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15

Yang, Jie, Dirk Hoffmeister, Lesley Liu, Xun Fu i Jon S. Thorson. "Natural product glycorandomization". Bioorganic & Medicinal Chemistry 12, nr 7 (kwiecień 2004): 1577–84. http://dx.doi.org/10.1016/j.bmc.2003.12.046.

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16

Butler, Mark S. "Natural products to drugs: natural product derived compounds in clinical trials". Natural Product Reports 22, nr 2 (2005): 162. http://dx.doi.org/10.1039/b402985m.

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Butler, Mark S. "Natural products to drugs: natural product-derived compounds in clinical trials". Natural Product Reports 25, nr 3 (2008): 475. http://dx.doi.org/10.1039/b514294f.

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18

Zhang, Xinyue, Mingyue Jiang, Na Niu, Zhijun Chen, Shujun Li, Shouxin Liu i Jian Li. "Natural-Product-Derived Carbon Dots: From Natural Products to Functional Materials". ChemSusChem 11, nr 1 (13.12.2017): 11–24. http://dx.doi.org/10.1002/cssc.201701847.

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19

Chen, Wei-Qiang, i T. E. Graedel. "In-use product stocks link manufactured capital to natural capital". Proceedings of the National Academy of Sciences 112, nr 20 (2.03.2015): 6265–70. http://dx.doi.org/10.1073/pnas.1406866112.

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In-use stock of a product is the amount of the product in active use. In-use product stocks provide various functions or services on which we rely in our daily work and lives, and the concept of in-use product stock for industrial ecologists is similar to the concept of net manufactured capital stock for economists. This study estimates historical physical in-use stocks of 91 products and 9 product groups and uses monetary data on net capital stocks of 56 products to either approximate or compare with in-use stocks of the corresponding products in the United States. Findings include the following: (i) The development of new products and the buildup of their in-use stocks result in the increase in variety of in-use product stocks and of manufactured capital; (ii) substitution among products providing similar or identical functions reflects the improvement in quality of in-use product stocks and of manufactured capital; and (iii) the historical evolution of stocks of the 156 products or product groups in absolute, per capita, or per-household terms shows that stocks of most products have reached or are approaching an upper limit. Because the buildup, renewal, renovation, maintenance, and operation of in-use product stocks drive the anthropogenic cycles of materials that are used to produce products and that originate from natural capital, the determination of in-use product stocks together with modeling of anthropogenic material cycles provides an analytic perspective on the material linkage between manufactured capital and natural capital.
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20

Butler, Mark S., Avril A. B. Robertson i Matthew A. Cooper. "Natural product and natural product derived drugs in clinical trials". Nat. Prod. Rep. 31, nr 11 (2014): 1612–61. http://dx.doi.org/10.1039/c4np00064a.

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The 25 Natural Product (NP)-derived drugs launched since 2008 and the 100 NP-derived compounds and 33 Antibody Drug Conjugates (ADCs) in clinical trials or in registration at the end of 2013 are reviewed.
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21

Nauffal, Mary, i Steven Gabardi. "Nephrotoxicity of Natural Products". Blood Purification 41, nr 1-3 (2016): 123–29. http://dx.doi.org/10.1159/000441268.

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Background: The manufacture and sale of natural products constitute a multi-billion dollar industry. Nearly a third of the American population admit to using some form of complementary or alternative medicine, with many using them in addition to prescription medications. Most patients fail to inform their healthcare providers of their natural product use and physicians rarely inquire. Annually, thousands of natural product-induced adverse events are reported to Poison Control Centers nationwide. Natural product manufacturers are not responsible for proving safety and efficacy, as the FDA does not regulate them. However, concerns exist surrounding the safety of natural products. Summary: This review provides details on natural products that have been associated with renal dysfunction. We have focused on products that have been associated with direct renal injury, immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, hepatorenal syndrome, and common adulterants or contaminants that are associated with renal dysfunction. Key Messages: The potential for natural products to cause renal dysfunction is justifiable. It is imperative that natural product use be monitored closely in all patients. Healthcare practitioners must play an active role in identifying patients using natural products and provide appropriate patient education.
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22

Nielsen, Alexander J., i James McNulty. "Polyphenolic natural products and natural product–inspired steroidal mimics as aromatase inhibitors". Medicinal Research Reviews 39, nr 4 (wrzesień 2018): 1274–93. http://dx.doi.org/10.1002/med.21536.

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23

O’Neill, Ellis. "Mining Natural Product Biosynthesis in Eukaryotic Algae". Marine Drugs 18, nr 2 (30.01.2020): 90. http://dx.doi.org/10.3390/md18020090.

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Eukaryotic algae are an extremely diverse category of photosynthetic organisms and some species produce highly potent bioactive compounds poisonous to humans or other animals, most notably observed during harmful algal blooms. These natural products include some of the most poisonous small molecules known and unique cyclic polyethers. However, the diversity and complexity of algal genomes means that sequencing-based research has lagged behind research into more readily sequenced microbes, such as bacteria and fungi. Applying informatics techniques to the algal genomes that are now available reveals new natural product biosynthetic pathways, with different groups of algae containing different types of pathways. There is some evidence for gene clusters and the biosynthetic logic of polyketides enables some prediction of these final products. For other pathways, it is much more challenging to predict the products and there may be many gene clusters that are not identified with the automated tools. These results suggest that there is a great diversity of biosynthetic capacity for natural products encoded in the genomes of algae and suggest areas for future research focus.
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24

Zhou, Quan, Kinya Hotta, Yaming Deng, Rui Yuan, Shu Quan i Xi Chen. "Advances in Biosynthesis of Natural Products from Marine Microorganisms". Microorganisms 9, nr 12 (10.12.2021): 2551. http://dx.doi.org/10.3390/microorganisms9122551.

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Natural products play an important role in drug development, among which marine natural products are an underexplored resource. This review summarizes recent developments in marine natural product research, with an emphasis on compound discovery and production methods. Traditionally, novel compounds with useful biological activities have been identified through the chromatographic separation of crude extracts. New genome sequencing and bioinformatics technologies have enabled the identification of natural product biosynthetic gene clusters in marine microbes that are difficult to culture. Subsequently, heterologous expression and combinatorial biosynthesis have been used to produce natural products and their analogs. This review examines recent examples of such new strategies and technologies for the development of marine natural products.
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25

Korimová, Ľ., D. Máté i P. Turek. "Influence of natural antioxidants on heat-untreated meat products quality". Czech Journal of Food Sciences 18, No. 4 (1.01.2000): 124–28. http://dx.doi.org/10.17221/8330-cjfs.

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The work deals with a study of the effect of natural antioxidants – rosemary extracts in powder and liquid forms, respectively, on the quality of a heat-untreated meat product. Effect of added antioxidants was estimated in samples taken from the meat product mixture, from a ready-made product immediately after smoking, after 28 days – at the expedition of the meat product and then after further 28 days of storing at different ambient temperatures. Marked positive effect of the applied antioxidants was noted especially during storing when the peroxide and thiobarbituric acid reactive substances (TBARS) values of fats increased more slowly compared to meat products manufactured without added antioxidants. Subsequent sensory analysis shows also preferences for the antioxidant treated meat products.
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26

Usuki, Toyonobu. "Borderless Natural Product Chemistry". Journal of Synthetic Organic Chemistry, Japan 76, nr 5 (1.05.2018): 422–25. http://dx.doi.org/10.5059/yukigoseikyokaishi.76.422.

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27

Sheridan, Cormac. "Recasting natural product research". Nature Biotechnology 30, nr 5 (maj 2012): 385–87. http://dx.doi.org/10.1038/nbt.2208.

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28

Herzon, Seth B., i Christopher D. Vanderwal. "Introduction: Natural Product Synthesis". Chemical Reviews 117, nr 18 (27.09.2017): 11649–50. http://dx.doi.org/10.1021/acs.chemrev.7b00520.

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29

Gladysz, J. A. "Introduction: Natural Product Synthesis". Chemical Reviews 105, nr 12 (grudzień 2005): 4235–36. http://dx.doi.org/10.1021/cr0509713.

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30

Frankel, Brenda A., i Dewey G. McCafferty. "Profiling Natural Product Biosynthesis". Chemistry & Biology 11, nr 3 (marzec 2004): 290–91. http://dx.doi.org/10.1016/j.chembiol.2004.03.007.

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31

Vinson, V. "A natural product map". Science 350, nr 6257 (8.10.2015): 174. http://dx.doi.org/10.1126/science.350.6257.174-a.

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32

Lawrence, Rebecca N. "Rediscovering natural product biodiversity". Drug Discovery Today 4, nr 10 (październik 1999): 449–51. http://dx.doi.org/10.1016/s1359-6446(99)01405-1.

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33

Arunotayanun, Warunya, i Simon Gibbons. "Natural product ‘legal highs’". Natural Product Reports 29, nr 11 (2012): 1304. http://dx.doi.org/10.1039/c2np20068f.

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34

MURAKI, NAOFUMI. "THE FIVE INDEPENDENCES AS NATURAL PRODUCTS". Infinite Dimensional Analysis, Quantum Probability and Related Topics 06, nr 03 (wrzesień 2003): 337–71. http://dx.doi.org/10.1142/s0219025703001365.

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Let [Formula: see text] be the class of all algebraic probability spaces. A "natural product" is, by definition, a map [Formula: see text] which is required to satisfy all the canonical axioms of Ben Ghorbal and Schürmann for "universal product" except for the commutativity axiom. We show that there exist only five natural products, namely tensor product, free product, Boolean product, monotone product and anti-monotone product. This means that, in a sense, there exist only five universal notions of stochastic independence in noncommutative probability theory.
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35

Davies, Stephen G., Ai M. Fletcher, Paul M. Roberts, James E. Thomson i Angus Yeung. "N-Acetylcolchinol Methyl Ether (a Natural Product); Suhailamine (a Phantom Natural Product)". Journal of Natural Products 82, nr 9 (5.09.2019): 2659–63. http://dx.doi.org/10.1021/acs.jnatprod.9b00595.

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36

Dunyak, Bryan M., i Jason E. Gestwicki. "Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds". Journal of Medicinal Chemistry 59, nr 21 (25.07.2016): 9622–44. http://dx.doi.org/10.1021/acs.jmedchem.6b00411.

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37

Mahajan, Aman, Renate Hans, Kelly Chibale i Vipan Kumar. "Synthesis and medicinal chemistry of selected antitubercular natural products and natural product derivatives". RSC Advances 4, nr 29 (2014): 15180. http://dx.doi.org/10.1039/c3ra46124f.

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38

Shen, Yuemao, i Xiaojiang Hao. "Natural product sciences: an integrative approach to the innovations of plant natural products". Science China Life Sciences 63, nr 11 (14.09.2020): 1634–50. http://dx.doi.org/10.1007/s11427-020-1799-y.

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39

Xu, Ling-Min, Yu-Fan Liang, Qin-Da Ye i Zhen Yang. "ChemInform Abstract: Diversity-oriented Syntheses of Natural Products and Natural Product-like Compounds". ChemInform 44, nr 32 (18.07.2013): no. http://dx.doi.org/10.1002/chin.201332219.

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40

Biermann, Friederike, Sebastian L. Wenski i Eric J. N. Helfrich. "Navigating and expanding the roadmap of natural product genome mining tools". Beilstein Journal of Organic Chemistry 18 (6.12.2022): 1656–71. http://dx.doi.org/10.3762/bjoc.18.178.

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Natural products are structurally highly diverse and exhibit a wide array of biological activities. As a result, they serve as an important source of new drug leads. Traditionally, natural products have been discovered by bioactivity-guided fractionation. The advent of genome sequencing technology has resulted in the introduction of an alternative approach towards novel natural product scaffolds: Genome mining. Genome mining is an in-silico natural product discovery strategy in which sequenced genomes are analyzed for the potential of the associated organism to produce natural products. Seemingly universal biosynthetic principles have been deciphered for most natural product classes that are used to detect natural product biosynthetic gene clusters using pathway-encoded conserved key enzymes, domains, or motifs as bait. Several generations of highly sophisticated tools have been developed for the biosynthetic rule-based identification of natural product gene clusters. Apart from these hard-coded algorithms, multiple tools that use machine learning-based approaches have been designed to complement the existing genome mining tool set and focus on natural product gene clusters that lack genes with conserved signature sequences. In this perspective, we take a closer look at state-of-the-art genome mining tools that are based on either hard-coded rules or machine learning algorithms, with an emphasis on the confidence of their predictions and potential to identify non-canonical natural product biosynthetic gene clusters. We highlight the genome mining pipelines' current strengths and limitations by contrasting their advantages and disadvantages. Moreover, we introduce two indirect biosynthetic gene cluster identification strategies that complement current workflows. The combination of all genome mining approaches will pave the way towards a more comprehensive understanding of the full biosynthetic repertoire encoded in microbial genome sequences.
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41

Findeis, Mark, Frank Schroeder, Steffen Creaser, Timothy McKee i Weiming Xia. "Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts". Medicines 2, nr 3 (30.06.2015): 127–40. http://dx.doi.org/10.3390/medicines2030127.

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42

Grigalunas, Michael, Annina Burhop, Andreas Christoforow i Herbert Waldmann. "Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery". Current Opinion in Chemical Biology 56 (czerwiec 2020): 111–18. http://dx.doi.org/10.1016/j.cbpa.2019.10.005.

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Baell, Jonathan B. "Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)". Journal of Natural Products 79, nr 3 (22.02.2016): 616–28. http://dx.doi.org/10.1021/acs.jnatprod.5b00947.

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Azman, M. A., M. R. M. Asyraf, A. Khalina, Michal Petrů, C. M. Ruzaidi, S. M. Sapuan, W. B. Wan Nik, M. R. Ishak, R. A. Ilyas i M. J. Suriani. "Natural Fiber Reinforced Composite Material for Product Design: A Short Review". Polymers 13, nr 12 (9.06.2021): 1917. http://dx.doi.org/10.3390/polym13121917.

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Natural fibers have attracted great attention from industrial players and researchers for the exploitation of polymer composites because of their “greener” nature and contribution to sustainable practice. Various industries have shifted toward sustainable technology in order to improve the balance between the environment and social and economic concerns. This manuscript aims to provide a brief review of the development of the foremost natural fiber-reinforced polymer composite (NFRPC) product designs and their applications. The first part of the manuscript presents a summary of the background of various natural fibers and their composites in the context of engineering applications. The behaviors of NFPCs vary with fiber type, source, and structure. Several drawbacks of NFPCs, e.g., higher water absorption rate, inferior fire resistance, and lower mechanical properties, have limited their applications. This has necessitated the development of good practice in systematic engineering design in order to attain optimized NRPC products. Product design and manufacturing engineering need to move in a mutually considerate manner in order to produce successful natural fiber-based composite material products. The design process involves concept design, material selection, and finally, the manufacturing of the design. Numerous products have been commercialized using natural fibers, e.g., sports equipment, musical instruments, and electronic products. In the end, this review provides a guideline for the product design process based on natural fibers, which subsequently leads to a sustainable design.
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45

S, Jani. "Novel Approaches in Green Extraction for Natural Medicines". Bioequivalence & Bioavailability International Journal 6, nr 1 (8.02.2022): 1–7. http://dx.doi.org/10.23880/beba-16000166.

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Green extraction is based on discovery and design of extraction process which will reduce unit operation, reduce energy consumption, reduce time consumption, reduce organic solvent use, alternate solvent with water or agro-solvent and ensure safe and high-quality extract. In this study the conventional extraction methods and various green extraction methods were compared. Both these studies on extraction process were done in the past, in this review those studies were compared. From this we can know that which method is suitable for extraction which will not harmful for the environment, promote the health of patient, produce by-product or co-product instead of waste.
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46

Padmavathy, Jagannathan, i Saravanan Devarajan. "Natural product as a source of prodrug". Bangladesh Journal of Pharmacology 12, nr 2 (5.05.2017): 5. http://dx.doi.org/10.3329/bjp.v12i2.31020.

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<p class="Abstract">The natural products are the chemical constituents that are generated from the living organism. The natural products are isolated from the plants, animals, and microorganisms which are used in drug design and drug discovery. Natural product is then modified by chemical synthesis as either total or semi-synthetic way. The natural products show various pharmacological activity which can be used for the treatment of a variety of diseases. Natural products could be regarded as a source of quantifiable and chemically pure known products and also natural products can be utilized as complex mixtures subjected to chemical variability. The present review article adds up the prodrugs from natural products as well as prodrugs developed from the natural products.</p>
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47

Hatakeyama, Susumi. "Fascinated by Natural Product Synthesis". Journal of Synthetic Organic Chemistry, Japan 78, nr 10 (1.10.2020): 986–89. http://dx.doi.org/10.5059/yukigoseikyokaishi.78.986.

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48

Hostettmann, K., A. Borloz, A. Urbain i A. Marston. "Natural Product Inhibitors of Acetylcholinesterase". Current Organic Chemistry 10, nr 8 (1.05.2006): 825–47. http://dx.doi.org/10.2174/138527206776894410.

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Abreu, Pedro M., i Paula S. Branco. "Natural product-like combinatorial libraries". Journal of the Brazilian Chemical Society 14, nr 5 (październik 2003): 675–712. http://dx.doi.org/10.1590/s0103-50532003000500002.

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50

Arora, Neelima, i Amit Kumar Banerjee. "Dereplication in Natural Product Discovery". Current Topics in Medicinal Chemistry 19, nr 2 (28.03.2019): 101–2. http://dx.doi.org/10.2174/156802661902190328145951.

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