Rozprawy doktorskie na temat „Natural product”
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Bringans, Scott D. "Studies on natural product derivatives : HIV therapies incorporating marine natural products". Thesis, University of Canterbury. Chemistry, 2001. http://hdl.handle.net/10092/6699.
Pełny tekst źródłaLi, I. C. K. "Natural product syntheses". Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375675.
Pełny tekst źródłaVollmer, Heidi R. "Biologically active natural product synthesis". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365780.
Pełny tekst źródłaMerifield, Eric. "Aspects of natural product synthesis". Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258148.
Pełny tekst źródłaLongbottom, Deborah Anne. "Polyenoyltetramic acid natural product synthesis". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620206.
Pełny tekst źródłaHunter, Ruth F. "Benzynes in natural product synthesis". Thesis, University of Manchester, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655226.
Pełny tekst źródłaPuniani, Evaloni Takavaha. "Novel natural product based anti-anxiety therapy and natural insecticides". Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/29155.
Pełny tekst źródłaVogt, Thomas. "Plant natural product glycosyl- and methyltransferases". [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=984745009.
Pełny tekst źródłaThite, Aniket Mohan. "Direct approaches toward natural product synthesis". [Ames, Iowa : Iowa State University], 2007.
Znajdź pełny tekst źródłaSperry, Jonathan. "Biomimetic oxidations in natural product synthesis". Thesis, University of Exeter, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425500.
Pełny tekst źródłaHinks, Jeremy David. "Metal carbenes in natural product synthesis". Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393940.
Pełny tekst źródłaElsworth, Jon D. "Prins cyclisations in natural product synthesis". Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445810.
Pełny tekst źródłaO'Neil, Ian Anthony. "Novel methods in natural product synthesis". Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38124.
Pełny tekst źródłaBolton, R. E. "Azide decomposition in natural product synthesis". Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/37947.
Pełny tekst źródłaDurbin, Matthew J. "Palladium catalysis for natural product synthesis". Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519010.
Pełny tekst źródłaZhang, Qian. "Natural Product Drug Discovery Targeting Cancer". Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370435.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
McArdle, Bernadette. "Natural Product Interactions with Biology Space". Thesis, Griffith University, 2007. http://hdl.handle.net/10072/366724.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Eskitis Institute for Cell and Molecular Therapies
Science, Environment, Engineering and Technology
Full Text
Liu, Yunqi. "Synthetic approaches toward natural product synthesis". Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187050.
Pełny tekst źródłaJensen, Mari N. "UA Licenses Patent for Natural Fungicide: Natural Product Fights Plant Diseases". College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2005. http://hdl.handle.net/10150/622198.
Pełny tekst źródłaWallace, Stephen. "A cascade approach towards the gephyrotoxins". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1f7b55ec-0346-498c-be03-81f3b9fde2f5.
Pełny tekst źródłaGhirardi, Elena. "Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis". Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398789.
Pełny tekst źródłaEl primer objetivo de esta Tesis Doctoral ha sido el estudio de la preparación de octahidro-1H-ciclopentapiridinas y octahidro-1H-indoles, a través de la síntesis de lactamas tricíclicas derivadas del (R)-fenilglicinol. Desafortunadamente, la reacción del ceto-éster 4 y del ceto-ácido 7, proporcionó solamente las eniminas 8 y 9. Por otro lado, la reacción de los derivados de ceto-ácidos 16 y 17 con (R)-fenilglicinol rindió únicamente una mezcla de productos 18, amidas conjugadas epímeras en la posición C-7a. Se ha sido estudiado la reacción de ciclocondensación de derivados de 2-oxociclohexano propionato convenientemente sustituidos en C-3 o en C-3 y C-5 con (R)-fenilglicinol y (1S,2R)-aminoindanol. Esta reacción conduce estereoselectivamente a lactamas tricíclicas o pentacíclicas quirales: se aisló mayoritariamente una lactama y se detectó la presencia de otra minoritaria. Al utilizar (1S,2R)-aminoindanol se obtuvieron mejores resultados. Estas lactamas son precursoras de cis-decahidroquinolinas, con sustituyentes en la posición 8 o en la posición 6 y 8. Las etapas clave de esta transformación son la reducción con alano y la eliminación del inductor quiral. Con esta metodología se ha preparado la decahidroquinolina 82, precursor de numerosos alcaloides de la familia Mirioneuron nutans. Además, presentamos el estudio de las reacciones de ciclocondensación con (R)-fenilglicinol a partir de ciclohexanonas que poseen una cadena de acetato en la posición C-1 y diversos sustituyentes alquilo o arilo en la posición C-3. Esta reacción conduce estereoselectivamente a una sola lactama tricíclica de las ocho posibles. A partir de las cetonas con un sustituyente alquilo en la posición C-3 aislamos una cantidad variable de enamida. Las lactamas mayoritarias, fueron convertidas en cis-octahidroindoles y cis-octahidroindolonas, que presentan un sustituyente en la posición 7 o en las posiciones 7 y 7a del anillo carbocíclico. Además, estudiamos la reactividad de las lactamas tricíclicas en medio ácido: la reacción con TiCl4 en THF, proporciona lactamas insaturadas con elevada estereoselectividad y buen rendimiento. La presencia de la función enamida, nos permitió preparar selectivamente nuevas cis y trans octahidroindolonas. Esta metodología nos permitió sintetizar el (a)-Licorano, un metabolito de la familia de las Amaryllidaceae.
Catterick, David. "The parallel synthesis of natural product families". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299756.
Pełny tekst źródłaRodil, Sandra Beltran. "Novel tandem processes and natural product studies". Thesis, University of York, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533505.
Pełny tekst źródłaMa, Wai Sheung. "Natural Product Drug Discovery against Tropical Diseases". Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3224.
Pełny tekst źródłaWalker, Deborah Anne. "Synthetic approaches towards the natural product forskolin". Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283449.
Pełny tekst źródłaLeadbeater, Claire. "Natural product biosynthesis : mechanistic and enzymatic studies". Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/15194.
Pełny tekst źródłaGoh, Wendy. "Studies directed towards the natural product nominine". Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/359288/.
Pełny tekst źródłaGallagher, Oliver Paul. "Structure and synthesis in natural product chemistry /". [St. Lucia, Qld. : s.n.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16653.pdf.
Pełny tekst źródłaFoley, Timothy Leyden. "Manipulating posttranslational modification in natural product biosynthesis". Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3390676.
Pełny tekst źródłaTitle from first page of PDF file (viewed Feb. 19, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 234-254).
Rodger, Robert. "Fused ring systems in natural product synthesis". Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27645.
Pełny tekst źródłaFernandez, Liza Sylvia. "Identification of Novel Natural Product Antimalarial Compounds". Thesis, Griffith University, 2010. http://hdl.handle.net/10072/366636.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Eskitis Institute for Cell and Molecular Therapies
Science, Environment, Engineering and Technology
Full Text
Heberlig, Graham William. "Harnessing Natural Product Biosynthesis to Access Macrocycles". Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39260.
Pełny tekst źródłaAngell, Scott Edward. "Genomic and metagenomic approaches to natural product chemistry". [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2671.
Pełny tekst źródłaHutchinson, John Howard. "The use of camphor in natural product synthesis". Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25830.
Pełny tekst źródłaScience, Faculty of
Chemistry, Department of
Graduate
Dias, Daniel Anthony, i danieldias@iprimus com au. "Natural Product Studies of Terrestrial and Marine Organisms". RMIT University. Applied Sciences, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091019.161302.
Pełny tekst źródłaNodwell, Matthew B. "Synthesis of biologically active marine natural product analogues". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/25745.
Pełny tekst źródłaFlasz, Jakub Tadeusz. "Total synthesis of the antitumour natural product, (-)- echinosporin". Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601477.
Pełny tekst źródłaFoot, Jonathan Stuart. "New synthetic methodology and antiviral natural product synthesis". Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412621.
Pełny tekst źródłaBarry, Conor. "Clavosolide A : Prins cyclisation in natural product synthesis". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413614.
Pełny tekst źródłaChrobak, Olga Maria. "Approaches to natural product antibiotic discovery from actinomycetes". Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/3992.
Pełny tekst źródłaYu, Miao. "Stereoselective Olefin Metathesis Reactions for Natural Product Synthesis". Thesis, Boston College, 2014. http://hdl.handle.net/2345/3861.
Pełny tekst źródłaChapter 1. The first examples of highly Z- and enantioselective ring-opening/cross-metathesis reactions are disclosed. Transformations involve meso cyclic olefin substrate and styrenes or enol ethers as olefin cross partners. A stereogenic-at-Mo monoaryloxide monopyrrolide (MAP) complex, prepared and used in situ, is discovered for the efficient formation of Z olefins. Such complex, bearing a relatively smaller adamantylimido and a larger chiral aryloxide ligand, leads to kinetic Z-selectivity due to the size differential. In most cases, the resulting disubstituted Z olefins are formed with excellent stereoselectivity (>95% Z). Chapter 2. The protocols for efficient Z-selective formation of macrocyclic disubstituted alkenes through catalytic ring-closing metathesis (RCM) is described. Stereoselective cyclizations are performed with either Mo- or W-based monoaryloxide monopyrrolide (MAP) complex at 22 oC. Synthetic utility of such broadly applicable transformation is demonstrated by synthesis of several macrocyclic natural products: relatively simpler molecules such as epilachnene (91% Z) and ambrettolide (91% Z), as well as advanced precursors to epothilones C and A (97% Z) and nakadomarin A (94% Z). Several principles of catalytic stereoselective olefin metathesis reactions are summarized based on the studies: 1) Mo-based catalysts are capable of delivering high activity but can be more prone to post-RCM isomerization. 2) W-based catalysts, though furnish lower activity, are less likely to cause the loss of kinetic Z selectivity by isomerization. 3) Reaction time is critical for retaining the stereoselectivity gained from kinetic, which not only applicable with MAP complexes but potentially with other complexes as well. 4) By using W-based catalyst, polycyclic alkenes can be accessed with sequential RCM reactions, without significant erosion of the existing Z olefins in the molecule. Chapter 3. An enantioselective total synthesis of anti-proliferative agent (+)-neopeltolide is presented. The total synthesis is accomplished in 11 steps for the longest linear sequence and 28 steps in total, including 8 catalytic reactions. Particularly, several Mo- or Ru-catalyzed stereoselective olefin metathesis reactions as well as N-hetereocyclic carbene (NHC)-catalyzed enantioselective boron conjugate addition to an acyclic enoate have proven to be effective for convergent construction of the molecule. The most important novelty of the study incorporates the explorations of feasibility of Z-selective cross-metathesis reactions to solve the challenge of installing two Z olefins with excellent selectivity
Thesis (PhD) — Boston College, 2014
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
Yu, Elsie. "Catalytic Stereoselective Olefin Metathesis for Natural Product Synthesis". Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:107714.
Pełny tekst źródłaChapter 1. Efficient Z-Selective Synthesis of Allylic- and Alkenyl Boronates by Catalytic Cross-Metathesis Efficient Z-selective cross-metathesis reactions to furnish Z-(pinacolato)-allylboron and Z-(pinacolato)alkenylboron compounds through catalytic cross-metathesis are disclosed. Z-allylic boron compounds are generated by the use of catalytic amounts of a W-based monoaryloxide monopyrrolide (MAP) complex in up to 91% yield and 96:4 dr after allylation to benzaldehyde. Alkenylboron compounds are prepared in high yields and high Z selectivity in up to 93% yield and 97:3 Z:E. Cross-metathesis reactions with 1,3-dienes and aryl olefins are efficient and highly Z-selective. Combination of cross-metathesis and cross-coupling to synthesize anticancer agent combretastatin A-4 highlights the utility of this approach. Chapter 2. Synthesis of Macrocyclic and Acyclic Z-Enoates and (E,Z) or (Z,E) Dienoates by Catalytic Cross-Metathesis The first examples of kinetically controlled catalytic olefin metathesis reactions to generate Z-α,β-unsaturated macrocyclic and acyclic esters are disclosed. The synthesis of (E,Z) or (Z,E)-dienoates are also presented. Reactions promoted by 3.0–10 mol % of Mo-based monoaryloxide monopyrrolide complex proceed to completion to the desired macrocycles within 2–6 h at room temperature. Macrocycles of diverse ring sizes are formed in 79:21 to >98:2 Z:E selectivity. Pure Z isomers can be obtained after purification in up to 75% yield. Acyclic Z-α,β-unsaturated esters are prepared in the presence of acetonitrile to avoid using excess amounts of the more valuable cross-partner substrate. Spectroscopic investigations and X-ray analysis rationalize the positive effect of acetonitrile in the reaction system. Linear (Z)-enoates are generated in up to 71% yield and up to >98:2 Z:E. (E,Z)-Dienoates are generated with high Z selectivity as well. The utility of the ring-closing metathesis and cross-metathesis is highlighted by the synthesis of an (+)-aspicilin precursor and the C1–C12 fragment of biologically active natural product (–)-laulimalide. Chapter 3. Application of E-Selective Catalytic Ring-Closing Metathesis in the Total Synthesis of Dolabelides A, B, C and D Efforts towards the enantioselective synthesis of the dolabelide family of anti-cancer macrolides is presented. Development of a total synthesis incorporating a late-stage kinetically E-selective RCM is illustrated. Previous attempts to synthesize the macrolide by ring-closing metathesis (RCM) have demonstrated poor efficiency and low selectivity for the E isomer. Methodology developed in our group with acyclic trisubstituted cross-metathesis demonstrates that high selectivity can be achieved with stereodefined 1,2-disubstituted and trisubstituted olefins by the use of the proper catalyst and reaction design. Modern catalytic and stereoselective approaches towards the two main fragments of dolabelide are presented. More efficient and concise routes will be pursued to highlight the utility of the proposed disconnections and practicality of the total synthesis
Thesis (PhD) — Boston College, 2018
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
O'Sullivan, Paul Thomas. "Natural product systems from eight-membered ring lactones". Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621632.
Pełny tekst źródłaWang, Xiaoling. "Natural product discovery and biosynthesis from soil actinobacteria". Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203796.
Pełny tekst źródłaZou, Da-ming, Molly Brewer, Francisco Garcia, Jean Feugang, Jian Wang, Roungyu Zang, Huaguang Liu i Changping Zou. "Cactus pear: a natural product in cancer chemoprevention". BioMed Central, 2005. http://hdl.handle.net/10150/610227.
Pełny tekst źródłathe suppression of tumor growth in nude mice was evaluated and compared with the effect of a synthetic retinoid N-(4-hydroxyphernyl) retinamide (4-HPR), which is currently used as a chemoprevention agent. Immunohistochemistry staining of tissue samples from animal tumors was performed to examine the gene expression.RESULTS:Cells exposed to cactus pear extracts had a significant increase in apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner. It also affected cell cycle of cancer cells by increasing G1 and decreasing G2 and S phases. Both 4-HPR and cactus pear extracts significantly suppressed tumor growth in nude mice, increased annexin IV expression, and decreased VEGF expression.CONCLUSION:Arizona cactus pear extracts effectively inhibited cell growth in several different immortalized and cancer cell cultures, suppressed tumor growth in nude mice, and modulated expression of tumor-related genes. These effects were comparable with those caused by a synthetic retinoid currently used in chemoprevention trials. The mechanism of the anti-cancer effects of cactus pear extracts needs to be further studied.
Andong, Koung Edzidzi Ursula-Claire. "Natural product derivative activates autophagy in cancer cells". Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/24489.
Pełny tekst źródłaGiampa, Geoffrey. "Investigations Into Carbon Nanotube And Natural Product Synthesis". ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/552.
Pełny tekst źródłaMesser, Roland. "Natural product-like compound libraries from D-(-) ribose /". [S.l.] : [s.n.], 2005. http://www.zb.unibe.ch/download/eldiss/05messer_r.pdf.
Pełny tekst źródłaWang, Dongdong. "Natural Product Chemical Probe Discovery against Parkinson’s Disease". Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367616.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
Salem, Shaimaa Mohamed. "Biosynthesis of Marineosin, a Spiroaminal Undecylprodiginine Natural Product". PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/936.
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