Artykuły w czasopismach: „Nanomaterials - Biomedical Applications”

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Wang, Jiali, Guo Zhao, Liya Feng i Shaowen Chen. "Metallic Nanomaterials with Biomedical Applications". Metals 12, nr 12 (12.12.2022): 2133. http://dx.doi.org/10.3390/met12122133.

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Metallic nanomaterials have attracted extensive attention in various fields due to their photocatalytic, photosensitive, thermal conducting, electrical conducting and semiconducting properties. Among all these fields, metallic nanomaterials are of particular importance in biomedical sensing for the detection of different analytes, such as proteins, toxins, metal ions, nucleotides, anions and saccharides. However, many problems remain to be solved, such as the synthesis method and modification of target metallic nanoparticles, inadequate sensitivity and stability in biomedical sensing and the biological toxicity brought by metallic nanomaterials. Thus, this Special Issue aims to collect research or review articles focused on electrochemical biosensing, such as metallic nanomaterial-based electrochemical sensors and biosensors, metallic oxide-modified electrodes, biological sensing based on metallic nanomaterials, metallic nanomaterial-based biological sensing devices and chemometrics for metallic nanomaterial-based biological sensing. Meanwhile, studies related to the synthesis and characterization of metallic nanomaterials are also welcome, and both experimental and theoretical studies are welcome for contribution as well.

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Ma, Haohua, Xin Qiao i Lu Han. "Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications". Biomimetics 8, nr 1 (22.03.2023): 128. http://dx.doi.org/10.3390/biomimetics8010128.

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Hydrogels, with 3D hydrophilic polymer networks and excellent biocompatibilities, have emerged as promising biomaterial candidates to mimic the structure and properties of biological tissues. The incorporation of nanomaterials into a hydrogel matrix can tailor the functions of the nanocomposite hydrogels to meet the requirements for different biomedical applications. However, most nanomaterials show poor dispersion in water, which limits their integration into the hydrophilic hydrogel network. Mussel-inspired chemistry provides a mild and biocompatible approach in material surface engineering due to the high reactivity and universal adhesive property of catechol groups. In order to attract more attention to mussel-inspired nanocomposite hydrogels, and to promote the research work on mussel-inspired nanocomposite hydrogels, we have reviewed the recent advances in the preparation of mussel-inspired nanocomposite hydrogels using a variety of nanomaterials with different forms (nanoparticles, nanorods, nanofibers, nanosheets). We give an overview of each nanomaterial modified or hybridized by catechol or polyphenol groups based on mussel-inspired chemistry, and the performances of the nanocomposite hydrogel after the nanomaterial’s incorporation. We also highlight the use of each nanocomposite hydrogel for various biomedical applications, including drug delivery, bioelectronics, wearable/implantable biosensors, tumor therapy, and tissue repair. Finally, the challenges and future research direction in designing mussel-inspired nanocomposite hydrogels are discussed.

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Oliveira, Mariana B., Feng Li, Jonghoon Choi i João F. Mano. "Nanomaterials for Biomedical Applications". Biotechnology Journal 16, nr 5 (maj 2021): 2170053. http://dx.doi.org/10.1002/biot.202170053.

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Das, Sumistha, Shouvik Mitra, S. M. Paul Khurana i Nitai Debnath. "Nanomaterials for biomedical applications". Frontiers in Life Science 7, nr 3-4 (grudzień 2013): 90–98. http://dx.doi.org/10.1080/21553769.2013.869510.

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Cao, Y. Charles. "Nanomaterials for biomedical applications". Nanomedicine 3, nr 4 (sierpień 2008): 467–69. http://dx.doi.org/10.2217/17435889.3.4.467.

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Oliveira, Mariana B., Feng Li, Jonghoon Choi i João F. Mano. "Nanomaterials for Biomedical Applications". Biotechnology Journal 15, nr 12 (grudzień 2020): 2000574. http://dx.doi.org/10.1002/biot.202000574.

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Aflori, Magdalena. "Smart Nanomaterials for Biomedical Applications—A Review". Nanomaterials 11, nr 2 (4.02.2021): 396. http://dx.doi.org/10.3390/nano11020396.

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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S, Lakshmana Prabu. "Toxicity Interactions of Nanomaterials in Biological System: A Pressing Priority". Bioequivalence & Bioavailability International Journal 6, nr 2 (15.07.2022): 1–6. http://dx.doi.org/10.23880/beba-16000173.

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Nanomaterials have made a rebellion in biomedical application especially treating several diseases due to its distinctive compositions. However, increased utilization of nanomaterials in biomedical applications has made an initiative to understand the possible interaction between the nanomaterials with the biological systems. These tiny particles enter into the body very easily and affect vulnerable systems which raise the interrogation of their potential effects on the susceptible organs. It is very crucial to comprehend the various exposure pathways, their movement, behavior and ultimate outcome. Specific and unique physicochemical properties, such as particle size and distribution, surface area, charge and coatings, particle shape/ structure, dissolution and aggregation, influence the nanomaterial interactions with cells. Toxicities in biological systems occurs as a result of a result of a variety of reasons including the production of ROS reactive oxygen species, degradation of the integrity of membrane and release of toxic metal ions thus preventing normal cell function. Various researchers have provided promising evidence that nanomaterial’s actively encompass and mediate chemical processes of cell, in addition to their passive interactions with cells. Certainly, it is very much essential to understand the possible toxic interactions of nanomaterial’s with the biological system as Nano toxicology. In this review, we emphasize the toxicological effects on different organs pertaining to nanomaterial-biological system interaction

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Matija, Lidija, Roumiana Tsenkova, Jelena Munćan, Mari Miyazaki, Kyoko Banba, Marija Tomić i Branislava Jeftić. "Fullerene Based Nanomaterials for Biomedical Applications: Engineering, Functionalization and Characterization". Advanced Materials Research 633 (styczeń 2013): 224–38. http://dx.doi.org/10.4028/www.scientific.net/amr.633.224.

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Since their discovery in 1985, fullerenes have attracted considerable attention. Their unique carbon cage structure provides numerous opportunities for functionalization, giving this nanomaterial great potential for applications in the field of medicine. Analysis of the chemical, physical, and biological properties of fullerenes and their derivatives showed promising results. In this study, functionalized fullerene based nanomaterials were characterized using near infrared spectroscopy, and a novel method - Aquaphotomics. These nanomaterials were then used for engineering a new skin cream formula for their application in cosmetics and medicine. In this paper, results of nanocream effects on the skin (using near infrared spectroscopy and aquaphotomics), and existing results of biocompatibility and cytotoxicity of fullerene base nanomaterials, are presented.

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Mgbemena, Chinedum, i Chika Mgbemena. "Carbon Nanomaterials for Tailored Biomedical Applications". Asian Review of Mechanical Engineering 10, nr 2 (5.11.2021): 24–33. http://dx.doi.org/10.51983/arme-2021.10.2.3167.

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Carbon Fibre (CF) and Carbon Nanotube (CNT) are typical Carbon nanomaterials that possess unique features which make them particularly attractive for biomedical applications. This paper is a review of the Carbon Fibre (CF) and Carbon Nanotube (CNT) for biomedical applications. In this paper, we describe their properties and tailored biomedical applications. The most recent state of the art in the biomedical application of CFs and CNTs were reviewed.

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Zhang, Yuhang, Kingsley Poon, Gweneth Sofia P. Masonsong, Yogambha Ramaswamy i Gurvinder Singh. "Sustainable Nanomaterials for Biomedical Applications". Pharmaceutics 15, nr 3 (12.03.2023): 922. http://dx.doi.org/10.3390/pharmaceutics15030922.

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Significant progress in nanotechnology has enormously contributed to the design and development of innovative products that have transformed societal challenges related to energy, information technology, the environment, and health. A large portion of the nanomaterials developed for such applications is currently highly dependent on energy-intensive manufacturing processes and non-renewable resources. In addition, there is a considerable lag between the rapid growth in the innovation/discovery of such unsustainable nanomaterials and their effects on the environment, human health, and climate in the long term. Therefore, there is an urgent need to design nanomaterials sustainably using renewable and natural resources with minimal impact on society. Integrating sustainability with nanotechnology can support the manufacturing of sustainable nanomaterials with optimized performance. This short review discusses challenges and a framework for designing high-performance sustainable nanomaterials. We briefly summarize the recent advances in producing sustainable nanomaterials from sustainable and natural resources and their use for various biomedical applications such as biosensing, bioimaging, drug delivery, and tissue engineering. Additionally, we provide future perspectives into the design guidelines for fabricating high-performance sustainable nanomaterials for medical applications.

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Mabrouk, Mostafa, Diganta B. Das, Zeinab A. Salem i Hanan H. Beherei. "Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties". Molecules 26, nr 4 (18.02.2021): 1077. http://dx.doi.org/10.3390/molecules26041077.

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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Popovtzer, Rachela. "Biomedical applications of gold nanomaterials". Nanomedicine 9, nr 13 (wrzesień 2014): 1903–4. http://dx.doi.org/10.2217/nnm.14.151.

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Bianchi, Michele, i Gianluca Carnevale. "Innovative Nanomaterials for Biomedical Applications". Nanomaterials 12, nr 9 (5.05.2022): 1561. http://dx.doi.org/10.3390/nano12091561.

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Taylor-Pashow, Kathryn M. L., Joseph Della Rocca, Rachel C. Huxford i Wenbin Lin. "Hybrid nanomaterials for biomedical applications". Chemical Communications 46, nr 32 (2010): 5832. http://dx.doi.org/10.1039/c002073g.

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Liu, Yanlan, i Jinjun Shi. "Antioxidative nanomaterials and biomedical applications". Nano Today 27 (sierpień 2019): 146–77. http://dx.doi.org/10.1016/j.nantod.2019.05.008.

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Harish, Vancha, Devesh Tewari, Manish Gaur, Awadh Bihari Yadav, Shiv Swaroop, Mikhael Bechelany i Ahmed Barhoum. "Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications". Nanomaterials 12, nr 3 (28.01.2022): 457. http://dx.doi.org/10.3390/nano12030457.

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In the last few decades, the vast potential of nanomaterials for biomedical and healthcare applications has been extensively investigated. Several case studies demonstrated that nanomaterials can offer solutions to the current challenges of raw materials in the biomedical and healthcare fields. This review describes the different nanoparticles and nanostructured material synthesis approaches and presents some emerging biomedical, healthcare, and agro-food applications. This review focuses on various nanomaterial types (e.g., spherical, nanorods, nanotubes, nanosheets, nanofibers, core-shell, and mesoporous) that can be synthesized from different raw materials and their emerging applications in bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, and agro-foods. Depending on their morphology (e.g., size, aspect ratio, geometry, porosity), nanomaterials can be used as formulation modifiers, moisturizers, nanofillers, additives, membranes, and films. As toxicological assessment depends on sizes and morphologies, stringent regulation is needed from the testing of efficient nanomaterials dosages. The challenges and perspectives for an industrial breakthrough of nanomaterials are related to the optimization of production and processing conditions.

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Rónavári, Andrea, Nóra Igaz, Dóra I. Adamecz, Bettina Szerencsés, Csaba Molnar, Zoltán Kónya, Ilona Pfeiffer i Monika Kiricsi. "Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications". Molecules 26, nr 4 (5.02.2021): 844. http://dx.doi.org/10.3390/molecules26040844.

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The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the production process and leaving hazardous waste materials behind. Moreover, the employed, often unpleasant chemicals can affect the biocompatibility of the generated particles and severely restrict their application possibilities. On these grounds, green synthetic approaches have emerged, offering eco-friendly, sustainable, nature-derived alternative production methods, thus attenuating the ecological footprint of the nanomaterial industry. In the last decade, a plethora of biological materials has been tested to probe their suitability for nanomaterial synthesis. Although most of these approaches were successful, a large body of evidence indicates that the green material or entity used for the production would substantially define the physical and chemical properties and as a consequence, the biological activities of the obtained nanomaterials. The present review provides a comprehensive collection of the most recent green methodologies, surveys the major nanoparticle characterization techniques and screens the effects triggered by the obtained nanomaterials in various living systems to give an impression on the biomedical potential of green synthesized silver and gold nanoparticles.

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Ansari, Mohammad Omaish, Kalamegam Gauthaman, Abdurahman Essa, Sidi A. Bencherif i Adnan Memic. "Graphene and Graphene-Based Materials in Biomedical Applications". Current Medicinal Chemistry 26, nr 38 (3.01.2019): 6834–50. http://dx.doi.org/10.2174/0929867326666190705155854.

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: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

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Ng, Cheng-Teng, Gyeong-Hun Baeg, Liya E. Yu, Choon-Nam Ong i Boon-Huat Bay. "Biomedical Applications of Nanomaterials as Therapeutics". Current Medicinal Chemistry 25, nr 12 (19.04.2018): 1409–19. http://dx.doi.org/10.2174/0929867324666170331120328.

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Background: As nanomaterials possess attractive physicochemical properties, immense research efforts have been channeled towards their development for biological and biomedical applications. In particular, zinc nanomaterials (nZnOs) have shown great potential for use in in the medical and pharmaceutical fields, and as tools for novel antimicrobial treatment, thereby capitalizing on their unique antimicrobial effects. Methods: We conducted a literature search using databases to retrieve the relevant articles related to the synthesis, properties and current applications of nZnOs in the diagnosis and treatment of diseases. A total of 86 publications were selected for inclusion in this review. Results: Besides studies on the properties and the methodology for the synthesis of nZnOs, many studies have focused on the application of nZnOs as delivery agents, biosensors and antimicrobial agents, as well as in bioimaging. Conclusion: This review gives an overview of the current development of nZnOs for their potential use as theranostic agents. However, more comprehensive studies are needed to better assess the valuable contributions and the safety of nZnOs in nanomedicine.

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Plachá, Daniela, i Josef Jampilek. "Graphenic Materials for Biomedical Applications". Nanomaterials 9, nr 12 (11.12.2019): 1758. http://dx.doi.org/10.3390/nano9121758.

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017–2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Kaushik, Nagendra, Neha Kaushik, Nguyen Linh, Bhagirath Ghimire, Anchalee Pengkit, Jirapong Sornsakdanuphap, Su-Jae Lee i Eun Choi. "Plasma and Nanomaterials: Fabrication and Biomedical Applications". Nanomaterials 9, nr 1 (14.01.2019): 98. http://dx.doi.org/10.3390/nano9010098.

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Application of plasma medicine has been actively explored during last several years. Treating every type of cancer remains a difficult task for medical personnel due to the wide variety of cancer cell selectivity. Research in advanced plasma physics has led to the development of different types of non-thermal plasma devices, such as plasma jets, and dielectric barrier discharges. Non-thermal plasma generates many charged particles and reactive species when brought into contact with biological samples. The main constituents include reactive nitrogen species, reactive oxygen species, and plasma ultra-violets. These species can be applied to synthesize biologically important nanomaterials or can be used with nanomaterials for various kinds of biomedical applications to improve human health. This review reports recent updates on plasma-based synthesis of biologically important nanomaterials and synergy of plasma with nanomaterials for various kind of biological applications.

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Min, Shengyi, Qiao Yu, Jiaquan Ye, Pengfei Hao, Jiayu Ning, Zhiqiang Hu i Yu Chong. "Nanomaterials with Glucose Oxidase-Mimicking Activity for Biomedical Applications". Molecules 28, nr 12 (7.06.2023): 4615. http://dx.doi.org/10.3390/molecules28124615.

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Glucose oxidase (GOD) is an oxidoreductase that catalyzes the aerobic oxidation of glucose into hydrogen peroxide (H2O2) and gluconic acid, which has been widely used in industrial raw materials production, biosensors and cancer treatment. However, natural GOD bears intrinsic disadvantages, such as poor stability and a complex purification process, which undoubtedly restricts its biomedical applications. Fortunately, several artificial nanomaterials have been recently discovered with a GOD-like activity and their catalytic efficiency toward glucose oxidation can be finely optimized for diverse biomedical applications in biosensing and disease treatments. In view of the notable progress of GOD-mimicking nanozymes, this review systematically summarizes the representative GOD-mimicking nanomaterials for the first time and depicts their proposed catalytic mechanisms. We then introduce the efficient modulation strategy to improve the catalytic activity of existing GOD-mimicking nanomaterials. Finally, the potential biomedical applications in glucose detection, DNA bioanalysis and cancer treatment are highlighted. We believe that the development of nanomaterials with a GOD-like activity will expand the application range of GOD-based systems and lead to new opportunities of GOD-mimicking nanomaterials for various biomedical applications.

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Abu Owida, Hamza, Nidal M. Turab i Jamal Al-Nabulsi. "Carbon nanomaterials advancements for biomedical applications". Bulletin of Electrical Engineering and Informatics 12, nr 2 (1.04.2023): 891–901. http://dx.doi.org/10.11591/eei.v12i2.4310.

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The development of new technologies has helped tremendously in delivering timely, appropriate, acceptable, and reasonably priced medical treatment. Because of developments in nanoscience, a new class of nanostructures has emerged. Nanomaterials, because of their small size, display exceptional physio-chemical capabilities such as enhanced absorption and reactivity, increased surface area, molar extinction coefficients, tunable characteristics, quantum effects, and magnetic and optical properties. Researchers are interested in carbon-based nanomaterials due to their unique chemical and physical properties, which vary in thermodynamic, biomechanical, electrical, optical, and structural aspects. Due to their inherent properties, carbon nanomaterials, including fullerenes, graphene, carbon nanotubes (CNTs), and carbon nanofibers (CNFs), have been intensively studied for biomedical applications. This article is a review of the most recent findings about the development of carbon-based nanomaterials for use in biosensing, drug delivery, and cancer therapy, among other things.

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Kumar, Santosh, Zhi Wang, Wen Zhang, Xuecheng Liu, Muyang Li, Guoru Li, Bingyuan Zhang i Ragini Singh. "Optically Active Nanomaterials and Its Biosensing Applications—A Review". Biosensors 13, nr 1 (4.01.2023): 85. http://dx.doi.org/10.3390/bios13010085.

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This article discusses optically active nanomaterials and their optical biosensing applications. In addition to enhancing their sensitivity, these nanomaterials also increase their biocompatibility. For this reason, nanomaterials, particularly those based on their chemical compositions, such as carbon-based nanomaterials, inorganic-based nanomaterials, organic-based nanomaterials, and composite-based nanomaterials for biosensing applications are investigated thoroughly. These nanomaterials are used extensively in the field of fiber optic biosensing to improve response time, detection limit, and nature of specificity. Consequently, this article describes contemporary and application-based research that will be of great use to researchers in the nanomaterial-based optical sensing field. The difficulties encountered during the synthesis, characterization, and application of nanomaterials are also enumerated, and their future prospects are outlined for the reader’s benefit.

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García, Isabel, Marco Marradi i Soledad Penadés. "Glyconanoparticles: multifunctional nanomaterials for biomedical applications". Nanomedicine 5, nr 5 (lipiec 2010): 777–92. http://dx.doi.org/10.2217/nnm.10.48.

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Lux, Francois, Stephane Roux, Pascal Perriat i Olivier Tillement. "Biomedical Applications of Nanomaterials Containing Gadolinium". Current Inorganic Chemistrye 1, nr 1 (1.06.2011): 117–29. http://dx.doi.org/10.2174/1877944111101010117.

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Zhao, Yu, Zhanzhan Zhang, Zheng Pan i Yang Liu. "Advanced bioactive nanomaterials for biomedical applications". Exploration 1, nr 3 (grudzień 2021): 20210089. http://dx.doi.org/10.1002/exp.20210089.

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Zhang, Y., T. Nayak, H. Hong i W. Cai. "Biomedical Applications of Zinc Oxide Nanomaterials". Current Molecular Medicine 13, nr 10 (listopad 2013): 1633–45. http://dx.doi.org/10.2174/1566524013666131111130058.

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Bhardwaj, Vinay, i Ajeet Kaushik. "Biomedical Applications of Nanotechnology and Nanomaterials". Micromachines 8, nr 10 (2.10.2017): 298. http://dx.doi.org/10.3390/mi8100298.

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Blum, Angela P., Jacquelin K. Kammeyer, Anthony M. Rush, Cassandra E. Callmann, Michael E. Hahn i Nathan C. Gianneschi. "Stimuli-Responsive Nanomaterials for Biomedical Applications". Journal of the American Chemical Society 137, nr 6 (6.02.2015): 2140–54. http://dx.doi.org/10.1021/ja510147n.

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Cheng, Chao-Min, i Kevin Chia-Wen Wu. "Nanomaterials and nanofabrication for biomedical applications". Science and Technology of Advanced Materials 14, nr 4 (marzec 2013): 040301. http://dx.doi.org/10.1088/1468-6996/14/4/040301.

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Park, Wooram, Heejun Shin, Bogyu Choi, Won-Kyu Rhim, Kun Na i Dong Keun Han. "Advanced hybrid nanomaterials for biomedical applications". Progress in Materials Science 114 (październik 2020): 100686. http://dx.doi.org/10.1016/j.pmatsci.2020.100686.

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Farr, Rebecca, Dong Shin Choi i Seung-Wuk Lee. "Phage-based nanomaterials for biomedical applications". Acta Biomaterialia 10, nr 4 (kwiecień 2014): 1741–50. http://dx.doi.org/10.1016/j.actbio.2013.06.037.

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Sortino, Salvatore. "Photoactivated nanomaterials for biomedical release applications". J. Mater. Chem. 22, nr 2 (2012): 301–18. http://dx.doi.org/10.1039/c1jm13288a.

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Tam, Dick Yan, i Pik Kwan Lo. "Multifunctional DNA Nanomaterials for Biomedical Applications". Journal of Nanomaterials 2015 (2015): 1–21. http://dx.doi.org/10.1155/2015/765492.

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The rapidly emerging DNA nanotechnology began with pioneer Seeman’s hypothesis that DNA not only can carry genetic information but also can be used as molecular organizer to create well-designed and controllable nanomaterials for applications in materials science, nanotechnology, and biology. DNA-based self-assembly represents a versatile system for nanoscale construction due to the well-characterized conformation of DNA and its predictability in the formation of base pairs. The structural features of nucleic acids form the basis of constructing a wide variety of DNA nanoarchitectures with well-defined shapes and sizes, in addition to controllable permeability and flexibility. More importantly, self-assembled DNA nanostructures can be easily functionalized to construct artificial functional systems with nanometer scale precision for multipurposes. Apparently scientists envision artificial DNA-based nanostructures as tool for drug loading andin vivotargeted delivery because of their abilities in selective encapsulation and stimuli-triggered release of cargo. Herein, we summarize the strategies of creating multidimensional self-assembled DNA nanoarchitectures and review studies investigating their stability, toxicity, delivery efficiency, loading, and control release of cargos in addition to their site-specific targeting and delivery of drug or cargo molecules to cellular systems.

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Wu, Shuilin, Zhengyang Weng, Xiangmei Liu, K. W. K. Yeung i Paul K. Chu. "Functionalized TiO2Based Nanomaterials for Biomedical Applications". Advanced Functional Materials 24, nr 35 (9.07.2014): 5464–81. http://dx.doi.org/10.1002/adfm.201400706.

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Lazăr, Andreea-Isabela, Kimia Aghasoleimani, Anna Semertsidou, Jahnavi Vyas, Alin-Lucian Roșca, Denisa Ficai i Anton Ficai. "Graphene-Related Nanomaterials for Biomedical Applications". Nanomaterials 13, nr 6 (17.03.2023): 1092. http://dx.doi.org/10.3390/nano13061092.

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This paper builds on the context and recent progress on the control, reproducibility, and limitations of using graphene and graphene-related materials (GRMs) in biomedical applications. The review describes the human hazard assessment of GRMs in in vitro and in vivo studies, highlights the composition–structure–activity relationships that cause toxicity for these substances, and identifies the key parameters that determine the activation of their biological effects. GRMs are designed to offer the advantage of facilitating unique biomedical applications that impact different techniques in medicine, especially in neuroscience. Due to the increasing utilization of GRMs, there is a need to comprehensively assess the potential impact of these materials on human health. Various outcomes associated with GRMs, including biocompatibility, biodegradability, beneficial effects on cell proliferation, differentiation rates, apoptosis, necrosis, autophagy, oxidative stress, physical destruction, DNA damage, and inflammatory responses, have led to an increasing interest in these regenerative nanostructured materials. Considering the existence of graphene-related nanomaterials with different physicochemical properties, the materials are expected to exhibit unique modes of interactions with biomolecules, cells, and tissues depending on their size, chemical composition, and hydrophil-to-hydrophobe ratio. Understanding such interactions is crucial from two perspectives, namely, from the perspectives of their toxicity and biological uses. The main aim of this study is to assess and tune the diverse properties that must be considered when planning biomedical applications. These properties include flexibility, transparency, surface chemistry (hydrophil–hydrophobe ratio), thermoelectrical conductibility, loading and release capacity, and biocompatibility.

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Wang, Ying, Shao-Kai Sun, Yang Liu i Zhanzhan Zhang. "Advanced hitchhiking nanomaterials for biomedical applications". Theranostics 13, nr 14 (2023): 4781–801. http://dx.doi.org/10.7150/thno.88002.

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BAO, HONGQIAN, YONGZHENG PAN i LIN LI. "RECENT ADVANCES IN GRAPHENE-BASED NANOMATERIALS FOR BIOMEDICAL APPLICATIONS". Nano LIFE 02, nr 01 (marzec 2012): 1230001. http://dx.doi.org/10.1142/s179398441100030x.

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Graphene, a two-dimensional nanomaterial reported for the first time in 2004, has been widely investigated for its novel physicochemical properties and potential applications. This review selectively summarizes the recent progress in using graphene-based nanomaterials for various biomedical applications. In particular, graphene-based sensors and biosensors, which are classified according to different sensing mechanisms and targets, are thoroughly discussed. Next, the utilization of graphene as nanocarriers for drug delivery, gene delivery and nanomedicine are demonstrated for potential cancer therapies. Finally, other graphene-based matrices, nanoscaffolds, and composites, which are used in bioapplications, are presented, followed by conclusions and perspective.

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Nienhaus, Karin, Yumeng Xue, Li Shang i Gerd Ulrich Nienhaus. "Protein adsorption onto nanomaterials engineered for theranostic applications". Nanotechnology 33, nr 26 (7.04.2022): 262001. http://dx.doi.org/10.1088/1361-6528/ac5e6c.

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Abstract The key role of biomolecule adsorption onto engineered nanomaterials for therapeutic and diagnostic purposes has been well recognized by the nanobiotechnology community, and our mechanistic understanding of nano-bio interactions has greatly advanced over the past decades. Attention has recently shifted to gaining active control of nano-bio interactions, so as to enhance the efficacy of nanomaterials in biomedical applications. In this review, we summarize progress in this field and outline directions for future development. First, we briefly review fundamental knowledge about the intricate interactions between proteins and nanomaterials, as unraveled by a large number of mechanistic studies. Then, we give a systematic overview of the ways that protein-nanomaterial interactions have been exploited in biomedical applications, including the control of protein adsorption for enhancing the targeting efficiency of nanomedicines, the design of specific protein adsorption layers on the surfaces of nanomaterials for use as drug carriers, and the development of novel nanoparticle array-based sensors based on nano-bio interactions. We will focus on particularly relevant and recent examples within these areas. Finally, we conclude this topical review with an outlook on future developments in this fascinating research field.

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Bououdina, M., S. Rashdan, J. L. Bobet i Y. Ichiyanagi. "Nanomaterials for Biomedical Applications: Synthesis, Characterization, and Applications". Journal of Nanomaterials 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/962384.

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Gómez, Luis Jesús Villarreal, Yanis Toledaño Magaña, José Manuel Cornejo Bravo, Ricardo Vera Graziano i Shengqiang Cai. "Cellular Responses to Nanomaterials with Biomedical Applications". Journal of Nanomaterials 2022 (8.04.2022): 1–3. http://dx.doi.org/10.1155/2022/9823140.

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Nanotechnology application to the biomedical field has gained significant interest. Great efforts have been made to develop nanogels, nanoparticles, and nanofibers, among others, to treat cardiovascular diseases, cancer, immune or metabolic system disorder, neurodegeneration, etc. The study of the cellular response against nanomaterials becomes essential for these potential applications. This Special Issue presents original research and review articles that illustrate and stimulate the advances in physiological processes that take place in tissue exposed to nanomaterials, such as cellular stress, adaptation mechanisms, immunological responses, biochemical pathways and cascades, pathologies, and clinical cases, among others.

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Bhattacharya, Priyanka, Dan Du i Yuehe Lin. "Bioinspired nanoscale materials for biomedical and energy applications". Journal of The Royal Society Interface 11, nr 95 (6.06.2014): 20131067. http://dx.doi.org/10.1098/rsif.2013.1067.

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The demand for green, affordable and environmentally sustainable materials has encouraged scientists in different fields to draw inspiration from nature in developing materials with unique properties such as miniaturization, hierarchical organization and adaptability. Together with the exceptional properties of nanomaterials, over the past century, the field of bioinspired nanomaterials has taken huge leaps. While on the one hand, the sophistication of hierarchical structures endows biological systems with multi-functionality, the synthetic control on the creation of nanomaterials enables the design of materials with specific functionalities. The aim of this review is to provide a comprehensive, up-to-date overview of the field of bioinspired nanomaterials, which we have broadly categorized into biotemplates and biomimics. We discuss the application of bioinspired nanomaterials as biotemplates in catalysis, nanomedicine, immunoassays and in energy, drawing attention to novel materials such as protein cages. Furthermore, the applications of bioinspired materials in tissue engineering and biomineralization are also discussed.

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Su, Shi, i Peter M. Kang. "Systemic Review of Biodegradable Nanomaterials in Nanomedicine". Nanomaterials 10, nr 4 (1.04.2020): 656. http://dx.doi.org/10.3390/nano10040656.

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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Díez-Pascual, Ana M. "Surface Engineering of Nanomaterials with Polymers, Biomolecules, and Small Ligands for Nanomedicine". Materials 15, nr 9 (30.04.2022): 3251. http://dx.doi.org/10.3390/ma15093251.

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Nanomedicine is a speedily growing area of medical research that is focused on developing nanomaterials for the prevention, diagnosis, and treatment of diseases. Nanomaterials with unique physicochemical properties have recently attracted a lot of attention since they offer a lot of potential in biomedical research. Novel generations of engineered nanostructures, also known as designed and functionalized nanomaterials, have opened up new possibilities in the applications of biomedical approaches such as biological imaging, biomolecular sensing, medical devices, drug delivery, and therapy. Polymers, natural biomolecules, or synthetic ligands can interact physically or chemically with nanomaterials to functionalize them for targeted uses. This paper reviews current research in nanotechnology, with a focus on nanomaterial functionalization for medical applications. Firstly, a brief overview of the different types of nanomaterials and the strategies for their surface functionalization is offered. Secondly, different types of functionalized nanomaterials are reviewed. Then, their potential cytotoxicity and cost-effectiveness are discussed. Finally, their use in diverse fields is examined in detail, including cancer treatment, tissue engineering, drug/gene delivery, and medical implants.

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Gandhi, Mansi, i Khairunnisa Amreen. "Emerging Trends in Nanomaterial-Based Biomedical Aspects". Electrochem 4, nr 3 (4.08.2023): 365–88. http://dx.doi.org/10.3390/electrochem4030024.

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Comprehending the interfacial interaction of nanomaterials (NMs) and biological systems is a significant research interest. NMs comprise various nanoparticles (NPs) like carbon nanotubes, graphene oxides, carbon dots, graphite nanopowders, etc. These NPs show a variety of interactions with biological interfaces via organic layers, therapeutic molecules, proteins, DNA, and cellular matrices. A number of biophysical and colloidal forces act at the morphological surface to regulate the biological responses of bio-nanoconjugates, imparting distinct physical properties to the NMs. The design of future-generation nano-tools is primarily based on the basic properties of NMs, such as shape, size, compositional, functionality, etc., with studies being carried out extensively. Understanding their properties promotes research in the medical and biological sciences and improves their applicability in the health management sector. In this review article, in-depth and critical analysis of the theoretical and experimental aspects involving nanoscale material, which have inspired various biological systems, is the area of focus. The main analysis involves different self-assembled synthetic materials, bio-functionalized NMs, and their probing techniques. The present review article focuses on recent emerging trends in the synthesis and applications of nanomaterials with respect to various biomedical applications. This article provides value to the literature as it summarizes the state-of-the-art nanomaterials reported, especially within the health sector. It has been observed that nanomaterial applications in drug design, diagnosis, testing, and in the research arena, as well as many fatal disease conditions like cancer and sepsis, have explored alongwith drug therapies and other options for the delivery of nanomaterials. Even the day-to-day life of the synthesis and purification of these materials is changing to provide us with a simplified process. This review article can be useful in the research sector as a single platform wherein all types of nanomaterials for biomedical aspects can be understood in detail.

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Tsukanov, Alexey, Boris Turk, Olga Vasiljeva i Sergey Psakhie. "Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials". Nanomaterials 12, nr 4 (15.02.2022): 650. http://dx.doi.org/10.3390/nano12040650.

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The increasing growth in the development of various novel nanomaterials and their biomedical applications has drawn increasing attention to their biological safety and potential health impact. The most commonly used methods for nanomaterial toxicity assessment are based on laboratory experiments. In recent years, with the aid of computer modeling and data science, several in silico methods for the cytotoxicity prediction of nanomaterials have been developed. An affordable, cost-effective numerical modeling approach thus can reduce the need for in vitro and in vivo testing and predict the properties of designed or developed nanomaterials. We propose here a new in silico method for rapid cytotoxicity assessment of two-dimensional nanomaterials of arbitrary chemical composition by using free energy analysis and molecular dynamics simulations, which can be expressed by a computational indicator of nanotoxicity (CIN2D). We applied this approach to five well-known two-dimensional nanomaterials promising for biomedical applications: graphene, graphene oxide, layered double hydroxide, aloohene, and hexagonal boron nitride nanosheets. The results corroborate the available laboratory biosafety data for these nanomaterials, supporting the applicability of the developed method for predictive nanotoxicity assessment of two-dimensional nanomaterials.

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Mitura, Katarzyna Anna, i Elżbieta Włodarczyk. "Fluorescent Nanodiamonds in Biomedical Applications". Journal of AOAC INTERNATIONAL 101, nr 5 (1.09.2018): 1297–307. http://dx.doi.org/10.5740/jaoacint.18-0044.

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Abstract Nanoparticles have an extended surface and a large surface area, which is the ratio of the size of the surface area to the volume. A functionalized surface can give rise to more modifications and therefore allows this nanomaterial to have new properties. Fluorescent molecules contain fluorophore, which is capable of being excited via the absorption of light energy at a specific wavelength and subsequently emitting radiation energy of a longer wavelength. A chemically modified surface of nanodiamond (ND; by carboxylation) demonstrated biocompatibility with DNA, cytochrome C, and antigens. In turn, fluorescent nanodiamonds (FNDs) belong to a group of new nanomaterials. Their surface can be modified by joining functional groups such as carboxyl, hydroxyl, or amino, after which they can be employed as a fluorescence agent. Their fluorescent properties result from defects in the crystal lattice. FNDs reach dimensions of 4–100 nm, have attributes such as photostability, long fluorescence lifetimes (10 ns), and fluorescence emission between 600 and 700 nm. They are also nontoxic, chemically inert, biocompatible, and environmentally harmless. The main purpose of this article was to present the medical applications of various types of modified NDs.

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Jiang, Tong, Wen Su, Yan Li, Mingyuan Jiang, Yonghong Zhang, Cory J. Xian i Yuankun Zhai. "Research Progress on Nanomaterials for Tissue Engineering in Oral Diseases". Journal of Functional Biomaterials 14, nr 8 (1.08.2023): 404. http://dx.doi.org/10.3390/jfb14080404.

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Due to their superior antibacterial properties, biocompatibility and high conductivity, nanomaterials have shown a broad prospect in the biomedical field and have been widely used in the prevention and treatment of oral diseases. Also due to their small particle sizes and biodegradability, nanomaterials can provide solutions for tissue engineering, especially for oral tissue rehabilitation and regeneration. At present, research on nanomaterials in the field of dentistry focuses on the biological effects of various types of nanomaterials on different oral diseases and tissue engineering applications. In the current review, we have summarized the biological effects of nanoparticles on oral diseases, their potential action mechanisms and influencing factors. We have focused on the opportunities and challenges to various nanomaterial therapy strategies, with specific emphasis on overcoming the challenges through the development of biocompatible and smart nanomaterials. This review will provide references for potential clinical applications of novel nanomaterials in the field of oral medicine for the prevention, diagnosis and treatment of oral diseases.

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