Gotowe bibliografie tematyczne / Nanomaterials - Biomedical Applications

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Gotowa bibliografia na temat „Nanomaterials - Biomedical Applications”

Autor: Grafiati

Data publikacji: 7 września 2023

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Artykuły w czasopismach na temat "Nanomaterials - Biomedical Applications"

Wang, Jiali, Guo Zhao, Liya Feng i Shaowen Chen. "Metallic Nanomaterials with Biomedical Applications". Metals 12, nr 12 (12.12.2022): 2133. http://dx.doi.org/10.3390/met12122133.

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Metallic nanomaterials have attracted extensive attention in various fields due to their photocatalytic, photosensitive, thermal conducting, electrical conducting and semiconducting properties. Among all these fields, metallic nanomaterials are of particular importance in biomedical sensing for the detection of different analytes, such as proteins, toxins, metal ions, nucleotides, anions and saccharides. However, many problems remain to be solved, such as the synthesis method and modification of target metallic nanoparticles, inadequate sensitivity and stability in biomedical sensing and the biological toxicity brought by metallic nanomaterials. Thus, this Special Issue aims to collect research or review articles focused on electrochemical biosensing, such as metallic nanomaterial-based electrochemical sensors and biosensors, metallic oxide-modified electrodes, biological sensing based on metallic nanomaterials, metallic nanomaterial-based biological sensing devices and chemometrics for metallic nanomaterial-based biological sensing. Meanwhile, studies related to the synthesis and characterization of metallic nanomaterials are also welcome, and both experimental and theoretical studies are welcome for contribution as well.

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Ma, Haohua, Xin Qiao i Lu Han. "Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications". Biomimetics 8, nr 1 (22.03.2023): 128. http://dx.doi.org/10.3390/biomimetics8010128.

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Hydrogels, with 3D hydrophilic polymer networks and excellent biocompatibilities, have emerged as promising biomaterial candidates to mimic the structure and properties of biological tissues. The incorporation of nanomaterials into a hydrogel matrix can tailor the functions of the nanocomposite hydrogels to meet the requirements for different biomedical applications. However, most nanomaterials show poor dispersion in water, which limits their integration into the hydrophilic hydrogel network. Mussel-inspired chemistry provides a mild and biocompatible approach in material surface engineering due to the high reactivity and universal adhesive property of catechol groups. In order to attract more attention to mussel-inspired nanocomposite hydrogels, and to promote the research work on mussel-inspired nanocomposite hydrogels, we have reviewed the recent advances in the preparation of mussel-inspired nanocomposite hydrogels using a variety of nanomaterials with different forms (nanoparticles, nanorods, nanofibers, nanosheets). We give an overview of each nanomaterial modified or hybridized by catechol or polyphenol groups based on mussel-inspired chemistry, and the performances of the nanocomposite hydrogel after the nanomaterial’s incorporation. We also highlight the use of each nanocomposite hydrogel for various biomedical applications, including drug delivery, bioelectronics, wearable/implantable biosensors, tumor therapy, and tissue repair. Finally, the challenges and future research direction in designing mussel-inspired nanocomposite hydrogels are discussed.

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Oliveira, Mariana B., Feng Li, Jonghoon Choi i João F. Mano. "Nanomaterials for Biomedical Applications". Biotechnology Journal 16, nr 5 (maj 2021): 2170053. http://dx.doi.org/10.1002/biot.202170053.

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Das, Sumistha, Shouvik Mitra, S. M. Paul Khurana i Nitai Debnath. "Nanomaterials for biomedical applications". Frontiers in Life Science 7, nr 3-4 (grudzień 2013): 90–98. http://dx.doi.org/10.1080/21553769.2013.869510.

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Cao, Y. Charles. "Nanomaterials for biomedical applications". Nanomedicine 3, nr 4 (sierpień 2008): 467–69. http://dx.doi.org/10.2217/17435889.3.4.467.

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Oliveira, Mariana B., Feng Li, Jonghoon Choi i João F. Mano. "Nanomaterials for Biomedical Applications". Biotechnology Journal 15, nr 12 (grudzień 2020): 2000574. http://dx.doi.org/10.1002/biot.202000574.

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Aflori, Magdalena. "Smart Nanomaterials for Biomedical Applications—A Review". Nanomaterials 11, nr 2 (4.02.2021): 396. http://dx.doi.org/10.3390/nano11020396.

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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S, Lakshmana Prabu. "Toxicity Interactions of Nanomaterials in Biological System: A Pressing Priority". Bioequivalence & Bioavailability International Journal 6, nr 2 (15.07.2022): 1–6. http://dx.doi.org/10.23880/beba-16000173.

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Nanomaterials have made a rebellion in biomedical application especially treating several diseases due to its distinctive compositions. However, increased utilization of nanomaterials in biomedical applications has made an initiative to understand the possible interaction between the nanomaterials with the biological systems. These tiny particles enter into the body very easily and affect vulnerable systems which raise the interrogation of their potential effects on the susceptible organs. It is very crucial to comprehend the various exposure pathways, their movement, behavior and ultimate outcome. Specific and unique physicochemical properties, such as particle size and distribution, surface area, charge and coatings, particle shape/ structure, dissolution and aggregation, influence the nanomaterial interactions with cells. Toxicities in biological systems occurs as a result of a result of a variety of reasons including the production of ROS reactive oxygen species, degradation of the integrity of membrane and release of toxic metal ions thus preventing normal cell function. Various researchers have provided promising evidence that nanomaterial’s actively encompass and mediate chemical processes of cell, in addition to their passive interactions with cells. Certainly, it is very much essential to understand the possible toxic interactions of nanomaterial’s with the biological system as Nano toxicology. In this review, we emphasize the toxicological effects on different organs pertaining to nanomaterial-biological system interaction

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Matija, Lidija, Roumiana Tsenkova, Jelena Munćan, Mari Miyazaki, Kyoko Banba, Marija Tomić i Branislava Jeftić. "Fullerene Based Nanomaterials for Biomedical Applications: Engineering, Functionalization and Characterization". Advanced Materials Research 633 (styczeń 2013): 224–38. http://dx.doi.org/10.4028/www.scientific.net/amr.633.224.

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Since their discovery in 1985, fullerenes have attracted considerable attention. Their unique carbon cage structure provides numerous opportunities for functionalization, giving this nanomaterial great potential for applications in the field of medicine. Analysis of the chemical, physical, and biological properties of fullerenes and their derivatives showed promising results. In this study, functionalized fullerene based nanomaterials were characterized using near infrared spectroscopy, and a novel method - Aquaphotomics. These nanomaterials were then used for engineering a new skin cream formula for their application in cosmetics and medicine. In this paper, results of nanocream effects on the skin (using near infrared spectroscopy and aquaphotomics), and existing results of biocompatibility and cytotoxicity of fullerene base nanomaterials, are presented.

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Mgbemena, Chinedum, i Chika Mgbemena. "Carbon Nanomaterials for Tailored Biomedical Applications". Asian Review of Mechanical Engineering 10, nr 2 (5.11.2021): 24–33. http://dx.doi.org/10.51983/arme-2021.10.2.3167.

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Carbon Fibre (CF) and Carbon Nanotube (CNT) are typical Carbon nanomaterials that possess unique features which make them particularly attractive for biomedical applications. This paper is a review of the Carbon Fibre (CF) and Carbon Nanotube (CNT) for biomedical applications. In this paper, we describe their properties and tailored biomedical applications. The most recent state of the art in the biomedical application of CFs and CNTs were reviewed.

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Rozprawy doktorskie na temat "Nanomaterials - Biomedical Applications"

Tang, Selina Vi Yu. "Synthesis of nanomaterials for biomedical applications". Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14101/.

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The field of nanotechnology is growing vastly, both as a field of research and in commercial applications. This rapid growth calls for synthesis methods which can produce high quality nanomaterials, while being scalable. This thesis describes an investigation into the use of a continuous hydrothermal reactor for the synthesis of nanomaterials, with potential use in three different biomedical applications – bone scaffolds, fluorescent biomarkers, and MRI contrast agents. The first chapter of this thesis provides an overview of nanotechnology: the advantages of nanoscale, the commercial industries which can benefit, and the predominant methods currently used to produce nanomaterials. Some advantages and drawbacks of each synthesis route are given, concluding with a description of the Nozzle reactor – the patented technology used for nanomaterial synthesis in this Thesis. Chapter 2 then focusses on the characterisation techniques used in this thesis, detailing the principles of how data is obtained, as well as highlighting the limitations of each method. With the background information in place, chapters 3, 4 and 5 describe more specific nanomaterials and how they can be applied to each of the aforementioned biomedical fields. These chapters provide the technical details of how various nanomaterials can be synthesised using the Nozzle reactor, and the structural data (crystallinity, particle size) obtained from these samples. Furthermore, the functional properties of these nanomaterials are tested and the results, along with a discussion of any trends, are presented. Finally, this thesis concludes with a summary of the results described and emphasises the key areas where further work can be conducted.

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Li, Tinghui. "Fullerene Based Nanomaterials for Biomedical Applications". Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/91439.

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Trimetallic nitride endohedral fullerenes (TNT-EMF) have been recognized for their multifunctional capabilities in biomedical applications. Functionalized gadolinium-loaded fullerenes attracted much attention as a potential new nanoplatform for next-generation magnetic resonance imaging (MRI) contrast agents, given their inherent higher 1H relaxivity than most commercial contrast agents. The fullerene cage is an extraordinarily stable species which makes it extremely unlikely to break and release the toxic Gd metal ions into the bioenvironment. In addition, radiolabeled metals could be encapsulated in this robust carbon cage to deliver therapeutic irradiation. In this dissertation, we aim to develop a series of functionalized TNT-EMFs for MRI detection of various pathological conditions, such as brain cancer, chronic osteomyelitis, and gastrointestinal (GI) tract. As a general introduction, Chapter 1 briefly introduces recent progress in developing metallofullerenes for next-generation biomedical applications. Of special interest are MRI contrast agents. Other potential biomedical applications, toxicity, stability and biodistribution of metallofullerenes are also discussed. Finally, the challenges and future outlook of using fullerene in biomedical and diagnosis applications are summarized at the end of this chapter. The large carbon surface area is ideally suited for multiple exo-functionalization approaches to modify the hydrophobic fullerene cage for a more hydrophilic bio-environment. Additionally, peptides and other agents are readily covalently attached to this nanoprobe for targeting applications. Chapter 2 presents the functionalized metallofullerenes conjugated with interleukin-13 peptide exhibits enhanced targeting of U-251 glioblastoma multiforme (GBM) cell lines and can be effectively delivered intravenously in an orthotopic GBM mouse model. Chapter 3 shows, with the specific targeting moiety, the functionalized metallofullerenes can be applied as a non-invasive imaging approach to detect and differentiate chronic post-traumatic osteomyelitis from aseptic inflammation. Fullerene is a powerful antioxidant due to delocalization of the π-electrons over the carbon cage, which can readily react with free radicals and subsequently delivers a cascade of downstream possessions in numerous biomedical applications. Chapter 4 investigates the antioxidative and anti-inflammatory properties of functionalized Gd3N@C80. This nanoplatform would hold great promise as a novel class of theranostic agent in combating oxidative stress and resolving inflammation, given their inherent MRI applications. In chapter 5, Gd3N@C80 is modified with polyethylene glycol (PEG) for working as MRI contrast agents for GI tract. The high molecular weight can prevent any appreciable absorption through the skin or mucosal tissue, and offer considerable advantages for localized agents in the GI tract. Besides the excellent contrast capability, the PEGylated-Gd3N@C80 exhibits outstanding radical scavenging ability, which can potentially eliminate the reactive oxygen species in GI tract. The biodistribution result suggests this nanoplatform can be worked as the potential contrast agent for GI tract at least for 6 hours. A novel amphiphilic Gd3N@C80 derivative is discussed in Chapter 6. It has been noticed for a long time the functionalization Gd3N@C80 contrast agents have higher relaxivity at lower concentrations. The explanation for the concentration dependency is not fully understood. In this work, the amphiphilic Gd3N@C80 derivative is used as the model to investigate the relationship between the relaxivity and concentration of the Gd-based fullerenes. Click chemistry has been extensively used in functionalization due to the high efficiency and technical simplicity of the reaction. Appendix A describes a new type of Sc3N@C80 derivative conducted by employing the click reaction. The structure of Sc3N@C80-alkynyl and Sc3N@C80- alkynyl-benzyl azide are characterized by NMR, MALDI-TOF, UV-Vis, and HPLC. The high yield of the click reaction can provide access to various derivatives which have great potential for application in medical and materials science. The functionalization and characterizations of Ho3N@C80 derivatives are reported in Appendix B. The contrast ability of Ho3N@C80 is directly compared with Gd3N@C80. The Ho-based fullerenes can be performed as the radiotherapeutic agents; the leaching study is performed to test the stability of carbon cage after irradiation. Appendix C briefly shows a new method to develop Gd3N@C80 based targeting platform, which can be used as the probe for chronic post-traumatic osteomyelitis.
PHD

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Wang, Weiqiang. "Prion inspired nanomaterials and their biomedical applications". Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670982.

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Els amiloides presenten una estructura fibril·lar molt ordenada. Molts d’aquests conjunts de proteïnes apareixen associats a malalties humanes. No obstant això, es pot aprofitar la naturalesa controlable, estable, ajustable i robusta de les fibres amiloides per crear nanomaterials amb una àmplia gamma d’aplicacions. Els prions funcionals constitueixen una classe particular d’amiloides. Aquestes proteïnes transmissibles presenten una arquitectura modular, amb un domini prió desordenat responsable del assemblatge i d’un o més dominis globulars que proporcionen l’activitat. És important destacar que la proteïna globular original es pot substituir per qualsevol proteïna d’interès, sense comprometre el potencial de fibril·lació. Aquestes fusions genètiques formen fibres en les quals el domini global roman plegat, formant nanoestructures funcionals. Tot i això, en molts casos, els impediments estèrics poden restringir l’activitat d’aquestes fibres. Aquesta limitació es pot solucionar disseccionant els dominis priònics en seqüències més curtes que mantenen les seves propietats d’auto-assemblatge alhora que permeten un millor accés a la proteïna en estat fibril·lar. En aquesta tesi doctoral, vam aprofitar el “soft amyloid core” (SAC) del prió de llevat Sup35p com una unitat de muntatge modular, que recapitula la propensió a l’agregació del domini priònic complet. Vam fusionar el SAC amb diferents proteïnes globulars d’interès que difereixen en la conformació i la mida, creant un mètode genètic general i senzill per generar nanofibres dotades de les funcionalitats desitjades. El modelatge computacional ens va permetre conèixer la relació entre la mida dels dominis globulars i la longitud del enllaç que els connecta al SAC, proporcionant les bases per al disseny de nanomaterials amb diferents propietats mesoscòpiques, ja siguin nanofibres o nanopartícules. Sobre aquesta base, hem dissenyat i produït, per primera vegada, nanopartícules amiloides esfèriques altament actives, no tòxiques, de mida definida, i s’han produït nanoestructures bifuncionals amb aplicació en el subministrament específic de fàrmacs. Les lliçons apreses en aquests exercicis van donar lloc a la construcció d’una nanofibrilla similar a un anticòs biespecífic amb potencial per la immunoteràpia. En resum, els nanomaterials funcionals de tipus priònic descrits aquí aprofiten l’enfocament de la fusió genètica per crear un nou conjunt d’estructures amb aplicacions en biomedicina i biotecnologia.
Los amiloides muestran una estructura fibrilar altamente ordenada. Muchos de estos ensamblajes aparecen asociados a enfermedades humanas. No obstante, la naturaleza controlable, estable, modulable y robusta de las fibras amiloides se puede emplear para construir nanomateriales notables con una amplia gama de aplicaciones. Los priones funcionales constituyen una clase particular de amiloides. Estas proteínas transmisibles exhiben una arquitectura modular, con un dominio priónico desordenado responsable del ensamblaje y uno o más dominios globulares que dan cuenta de la actividad. Cabe destacar que la proteína globular original se puede reemplazar con cualquier proteína de interés sin comprometer el potencial de fibrilación. Estas fusiones genéticas forman fibrillas en las que el dominio globular permanece plegado, lo que genera nanoestructuras funcionales. Sin embargo, en muchos casos, el impedimento estérico restringe la actividad de estas fibrillas. Esta limitación puede resolverse diseccionando los dominios de priones en secuencias más cortas que mantengan sus propiedades de autoensamblado mientras permiten un mejor acceso a la proteína en el estado fibrilar. En esta tesis doctoral, exploramos el "soft amyloid core" (SAC) del prion de levadura Sup35p como una unidad modular de autoensamblaje, que recapitula la propensión a la agregación del dominio priónico completo. Fusionamos el SAC con diferentes proteínas globulares de interés que difieren en conformación y tamaños, creando un enfoque genético general y directo para generar nanofibrillas dotadas de las funcionalidades deseadas. El modelado computacional nos permitió obtener información sobre la relación entre el tamaño de los dominios globulares y la longitud del conector que los une con el SAC, proporcionando la base para el diseño de nanomateriales con diferentes propiedades mesoscópicas, ya sean nanofibrillas o nanopartículas. Sobre esta base, diseñamos y producimos, por primera vez, nanopartículas amiloides esféricas, altamente activas, no tóxicas, de tamaño definido, y diseñamos nanoestructuras bifuncionales con aplicación en la administración dirigida de fármacos. Las lecciones aprendidas en estos ejercicios permitieron la construcción de una nanofibrilla similar a un anticuerpo biespecífico con potencial para su uso en inmunoterapia. En resumen, los nanomateriales funcionales similares a los priones descritos aquí aprovechan la metodología de fusión genética para generar un nuevo conjunto de estructuras con aplicación en biomedicina y biotecnología.
Amyloids display a highly ordered fibrillar structure. Many of these assemblies appear associated with human disease. However, the controllable, stable, tunable, and robust nature of amyloid fibrils can be exploited to build up remarkable nanomaterials with a wide range of applications. Functional prions constitute a particular class of amyloids. These transmissible proteins exhibit a modular architecture, with a disordered prion domain responsible for the assembly and one or more globular domains that account for the activity. Importantly, the original globular protein can be replaced with any protein of interest, without compromising the fibrillation potential. These genetic fusions form fibrils in which the globular domain remains folded, rendering functional nanostructures. However, in many cases, steric hindrance restricts the activity of these fibrils. This limitation can be solved by dissecting prion domains into shorter sequences that keep their self-assembling properties while allowing better access to the protein in the fibrillar state. In this PhD thesis, we exploited the "soft amyloid core (SAC)" of the Sup35p yeast prion as a modular self-assembling unit, which recapitulates the aggregation propensity of the complete prion domain. We fused the SAC to different globular proteins of interest differing in conformation and sizes, building up a general and straightforward genetic approach to generate nanofibrils endowed with desired functionalities. Computational modeling allowed us to gain insights into the relationship between the size of the globular domains and the length of the linker that connects them to the SAC, providing the basis for the design of nanomaterials with different mesoscopic properties, either nanofibrils or nanoparticles. On this basis, we designed and produced, for the first time, highly active, non-toxic, spherical amyloid nanoparticles of defined size and engineered bifunctional nanostructures with application in targeted drug delivery. The lessons learned in these exercises resulted in the construction of a bispecific antibody-like nanofibril, showing potential in immunotherapy. In summary, the prion-like functional nanomaterials described here take profit of the genetic fusion approach to render a novel set of structures with application in biomedicine and biotechnology.

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GAZZI, ARIANNA. "IMMUNOCOMPATIBILITY AND BIOMEDICAL APPLICATIONS OF NEW NANOMATERIALS". Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3015205.

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Nanomaterial’s properties can be exploited for diagnostic and medical purposes or combined and fine-tuned to obtain multimodal nanoplatforms available for theranostics. For instance, independently from the specific nanomedicine goal, these nanomaterials will immediately contact the organism immune cells, as body’s first defensive barrier. Therefore, a critical step for future translational applications is represented by the assessment of nanomaterial’s impact on the immune system. In this view, the nanoimmunity-by-design concept is the leitmotiv of the Ph.D. project, it consists in the characterization of graphene and other nanomaterials not only from a chemical-physical point of view but also based on the effects that can occur towards the immune system. To pursue this goal, a new experimental model based on human primary immune cell populations, in particular on red blood cells (RBCs) and peripheral blood mononuclear cells (PBMCs) that can be adopted for the immune assessment of a large number of nanomaterials, was developed. To achieve this purpose, the Ph.D. project focused on the immunological characterization of some of the main promising nanomaterials for biomedical applications: carbon nanodots, ultrasmall silica nanoparticles, graphene-oxide-based hydrogels, titanium-based transition metal carbides, and polystyrene nanoparticles, adopting single- cell level techniques (i.e. flow cytometry and single-cell mass cytometry)
Nanomaterial’s properties can be exploited for diagnostic and medical purposes or combined and fine-tuned to obtain multimodal nanoplatforms available for theranostics. For instance, independently from the specific nanomedicine goal, these nanomaterials will immediately contact the organism immune cells, as body’s first defensive barrier. Therefore, a critical step for future translational applications is represented by the assessment of nanomaterial’s impact on the immune system. In this view, the nanoimmunity-by-design concept is the leitmotiv of the Ph.D. project, it consists in the characterization of graphene and other nanomaterials not only from a chemical-physical point of view but also based on the effects that can occur towards the immune system. To pursue this goal, a new experimental model based on human primary immune cell populations, in particular on red blood cells (RBCs) and peripheral blood mononuclear cells (PBMCs) that can be adopted for the immune assessment of a large number of nanomaterials, was developed. To achieve this purpose, the Ph.D. project focused on the immunological characterization of some of the main promising nanomaterials for biomedical applications: carbon nanodots, ultrasmall silica nanoparticles, graphene-oxide-based hydrogels, titanium-based transition metal carbides, and polystyrene nanoparticles, adopting single- cell level techniques (i.e. flow cytometry and single-cell mass cytometry)

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Spear, Rose Louis. "Peptide functionalisation of carbon nanomaterials for biomedical applications". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609475.

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Roth, Kristina L. "Development of Metal-based Nanomaterials for Biomedical Applications". Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85365.

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New synthetic advances in the control of nanoparticle size and shape along with the development of new surface modifications facilitates the growing use of nanomaterials in biomedical applications. Of particular interest are functional and biocompatible nanomaterials for sensing, imaging, and drug delivery. The goal of this research is to tailor the function of nanomaterials for biomedical applications by improving the biocompatibility of the systems. Our work demonstrates both a bottom up and a post synthetic approach for incorporating stability, stealth, and biocompatibility to metal based nanoparticle systems. Two main nanomaterial projects are the focus of this dissertation. We first investigated the development of a green synthetic procedure to produce gold nanoparticles for biological imaging and sensing. The size and morphology of gold nanoparticles directly impact their optical properties, which are important for their function as imaging agents or their use in sensor systems. In this project, a synthetic route based on the natural process of biomineralization was developed, where a designed protein scaffold initiates the nucleation and subsequent growth of gold ions. To gain insight into controlling the size and morphology of the synthesized nanoparticles, interactions between the gold ions and the protein surface were studied along with the effect of ionic strength on interactions and then subsequent crystal growth. We are able to control the size and morphology of the gold nanoparticles by altering the concentration or identity of protein scaffold, salt, or reducing agent. The second project involves the design and optimization of metal organic framework nanoparticles for an external stimulus triggered drug delivery system. This work demonstrates the advantages of using surface coatings for improved stability and functionalization. We show that the addition of a polyethylene glycol surface coating improved the colloidal stability and biocompatibility of the system. The nanoparticle was shown to successfully encapsulate a variety of small molecule cargo. This is the first report of photo-triggered degradation and subsequent release of the loaded cargo as a mechanism of stimuli-controlled drug delivery. Each of the aforementioned projects demonstrates the design, synthesis, and optimization of metal-based systems for use in biomedical applications.
Ph. D.

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Ge, Haobo. "New functionalised carbon based nanomaterials for biomedical imaging applications". Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681050.

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Zhang, Jianfei. "The Preparation, Functionalization and Biomedical Applications of Carbonaceous Nanomaterials". Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/77361.

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Carbon nanomaterials have attracted significant attention in the past decades for their unique properties and potential applications in many areas. This dissertation addresses the preparation, functionalization and potential biomedical applications of various carbonaceous nanomaterials. Trimetallic nitride template endohedral metallofullerenes (TNT-EMFs, M₃N@C₈₀, M = Gd, Lu, etc.) are some of the most promising materials for biomedical applications. Water-soluble Gd₃N@C₈₀ was prepared by the functionalization with poly(ethylene glycol) (PEG) and hydroxyl groups (Gd₃N@C₈₀[DiPEG(OH)ₓ]). The length of the PEG chain was tuned by changing the molecular weight of the PEG from 350 to 5000. The 1H magnetic resonance relaxivities of the materials were studied at 0.35 T, 2.4 T and 9.4 T. Their relaxivities were found to increase as the molecular weight of the PEG decreased, which is attributed to the increasing aggregate size. The aggregate sizes were confirmed by dynamic light scattering. In vivo study suggested that Gd3N@C₈₀[DiPEG(OH)x] was a good candidate for magnetic resonance imaging (MRI) contrast agents. Another facile method was also developed to functinalize Gd₃N@C₈₀ with both carboxyl and hydroxyl groups by reaction with succinic acyl peroxide and sodium hydroxide thereafter. The product was determined to be Gd₃N@C₈₀(OH)~₂₆(CH₂CH₂COOM)~₁₆ (M = Na, H) by X-ray photoelectron spectrometry. The Gd₃N@C₈₀(OH)~₂₆(CH₂CH₂COOM)~₁₆ also exhibited high relaxivity, and aggregates in water. The research on both pegylated and carboxylated Gd₃N@C₈₀ suggests that aggregation and rotational correlation time plays an important role in relaxation, and the relaxivities and aggregation of the water-soluble metallofullerenes can be tuned by varying the molecular weight of the functionality. TNT-EMFs can be encapsulated inside single-walled carbon nanotubes (SWNTs) to form "peapod" structures by heating the mixture of TNT-EMFs and SWNTs in a vacuum. The peapods were characterized by Raman spectrometry and transmission electron microscopy (TEM). The peapods were then functionalized with hydroxyl groups by a high speed vibration milling (HSVM) method in the presence of KOH. The functionalized Gd-doped peapods exhibited high relaxivites and had an additional advantage of "double carbon wall" protection of the toxic Gd atoms from possible leaking. The HSVM method was modified by using succinic acyl peroxide. The modified HSVM method could functionalize multi-walled carbon nanotubes (MWNT) and single-walled carbon nanohorns (SWNHs) with carboxyl groups. In the presence of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC), carboxylate MWNTs and SWNHs could be conjugated with CdSe/ZnS quantum dots (QDs). TNT-EMFs were also encapsulated inside SWNHs to form SWNH peapods. SWNH peapods were functionalized by the modified HSVM method and then were conjugated with CdSe/ZnS QDs. The peapods were characterized by TEM. In vitro and in vivo studies indicated that SWNH peapods could serve as a multimodal diagnostic agent: MRI contrast agent (Gd₃N@C₈₀ encapsulated), radio-active therapeutic agent (Lu₃N@C₈₀ encapsulated) and optical imaging agent (QDs).
Ph. D.

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Crisan, Daniel Nicolae. "Polymeric scaffolds as building blocks for nanomaterials with biomedical applications". Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8395/.

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Functional polymers are emerging as strong candidates for a variety of biomedical applications, but progress in this field is slow due to the difficulties associated with the synthesis of libraries of polymers. Polymeric scaffolds facilitate the rapid synthesis of such functional polymers by employing click chemistries as a tool for post-polymerisation modification. Acrylic and acetylene based polyhydrazides have been explored as potential scaffolds for the in situ screening of functionalised polymers for biomedical applications. Poly(acryloyl hydrazide) was prepared from commercially available starting materials using RAFT polymerisation in a three step synthesis, and its postpolymerisation modification using a variety of hydrophilic and hydrophobic aldehydes was investigated. Biocompatible solvents and reaction conditions were determined such that the postpolymerisation modification could be achieved with good yields or better. The applicability of the scaffold was shown during the in situ screening of functional polymers for siRNA delivery, which required no isolation or purification of candidate polymers. Poly(4-ethynylbenzohydrazide) was synthesised using rhodium catalysed polymerisation conditions, towards achieving a helical polymer scaffold. Despite the lack of solubility in aqueous solvents, the stability and post-polymerisation modification was analysed in a variety of conditions, opening the possibility of synthesising biodegradable mimics to naturally occurring helical moieties.

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Baghdadi, Neazar Eassam. "Design and synthesis of iron oxide nanomaterials for biomedical applications". Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:14799.

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Nanotechnology products have huge potential to be a part of the developments in various fields, including functional materials, electronics and medicine. Using nanomaterials in medical applications has been successful for disease diagnosis and drug delivery systems. One of the safest and most versatile nanomaterials utilized for medical purposes are iron oxide nanomaterials. This thesis presents the synthesis, coating and targeting vector modification of iron oxide materials for several biomedical applications including multimodal imaging and cancer cell targeting. Iron oxide nanorods (NRDs) were produced and coated with silica shells as well as other surface modifying molecules including azamacrocycles (DO3A) and polyethylene glycol chains (PEG) which were attached in a one pot reaction. The presence of PEG on the NRDs surface gave improved suspension stability over a wide range of salt concentrations and pH values. Radiolabelling of the NRDs was demonstrated with the positron emitting radioisotope ⁶⁸Ga. The use of nanorods as magnetic resonance imaging (MRI) contrast agents gave a two-fold increase in T2 relaxivity (180 s⁻¹) compared to previous work using spherical nanoparticles. The ⁶⁸Ga labelled NRD constructs show high radiochemical stability against transferrin challenge over a 3 h incubation period. An in vivo bio-distribution study was carried out by intravenously injecting a CD1 nude female mice with 2 mg of (NRDs-PEG), then multimodal imaging analysis was performed using MRI and positron emission tomography (PET) imaging. The NRDs with sizes between 100 to 200 nm showed rapid accumulation in the liver after 5 min due to uptake by macrophages and Kupffer cells as part of reticuloendothelial system, and a small quantity accumulated in the lung and spleen. It was also observed that in the MRI T2 weighted image, the liver is significantly darker than the T1 weighted imaging which confirms the sample accumulation. The multimodal images proved that the radiolabelled NRDs were stable in vivo on the timescale of the imaging study. Iron oxide nanoparticles (IONPs) were functionalised for targeting cancer cells. The IONPs were conjugated to a chemokine receptor targeting vector and the targeting properties were tested in vitro using Jurkat cancer cells with flow cytometry in an antibody competition assay. The NPs showed 100% inhibition of the anti-CXCR4 antibody binding in this assay.

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Książki na temat "Nanomaterials - Biomedical Applications"

Santra, Tuhin Subhra, i Loganathan Mohan, red. Nanomaterials and Their Biomedical Applications. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6252-9.

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Kim, Jin-Chul, Madhusudhan Alle i Azamal Husen, red. Smart Nanomaterials in Biomedical Applications. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-84262-8.

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Ciofani, Gianni, i Arianna Menciassi, red. Piezoelectric Nanomaterials for Biomedical Applications. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28044-3.

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Zhang, Mei, Rajesh R. Naik i Liming Dai, red. Carbon Nanomaterials for Biomedical Applications. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22861-7.

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Arianna, Menciassi, i SpringerLink (Online service), red. Piezoelectric Nanomaterials for Biomedical Applications. Wyd. 2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012.

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Kanchi, Suvardhan, Shakeel Ahmed, Myalowenkosi I. Sabela i Chaudhery Mustansar Hussain, red. Nanomaterials: Biomedical, Environmental, and Engineering Applications. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781119370383.

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Mozafari, M. Reza, red. Nanomaterials and Nanosystems for Biomedical Applications. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-6289-6.

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Mohanan, P. V., i Sudha Kappalli, red. Biomedical Applications and Toxicity of Nanomaterials. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7834-0.

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Chen, Chunying, i Haifang Wang, red. Biomedical Applications and Toxicology of Carbon Nanomaterials. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527692866.

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Yoo, Je Min. Studies on Graphene-Based Nanomaterials for Biomedical Applications. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2233-8.

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Części książek na temat "Nanomaterials - Biomedical Applications"

Pasika, Shashank Reddy, Raviteja Bulusu, Balaga Venkata Krishna Rao, Nagavendra Kommineni, Pradeep Kumar Bolla, Shabari Girinath Kala i Chandraiah Godugu. "Nanotechnology for Biomedical Applications". W Nanomaterials, 297–327. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7963-7_11.

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Yang, Kai, i Zhuang Liu. "Nanographene in Biomedical Applications". W Biomedical Nanomaterials, 251–82. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527694396.ch10.

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Munaweera, Imalka, i M. L. Chamalki Madhusha. "SNM for Biomedical Applications". W Smart Nanomaterials, 29–48. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003366270-3.

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Zhang, Hao, i Youqing Shen. "Microfluidics Applications in Cancer Drug Delivery". W Biomedical Nanomaterials, 117–48. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527694396.ch5.

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Norman, Ashreen, Emmellie Laura Albert, Dharshini Perumal i Che Azurahanim Che Abdullah. "Biomedical Applications of Nanomaterials". W Handbook of Green and Sustainable Nanotechnology, 1–23. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-69023-6_35-1.

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Norman, Ashreen, Emmellie Laura Albert, Dharshini Perumal i Che Azurahanim Che Abdullah. "Biomedical Applications of Nanomaterials". W Handbook of Green and Sustainable Nanotechnology, 1699–720. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-16101-8_35.

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Fahmy, M. D., H. E. Jazayeri, M. Razavi, M. Razavi, M. Hashemi, M. Hashemi, M. Omidi i in. "Biomedical Applications of Intelligent Nanomaterials". W Intelligent Nanomaterials, 199–245. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119242628.ch8.

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Lülf, Henning, André Devaux, Eko Adi Prasetyanto i Luisa De Cola. "Porous nanomaterials for biomedical applications". W Organic Nanomaterials, 487–507. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118354377.ch22.

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Golshadi, Masoud, i Michael G. Schrlau. "Carbon Nanostructures in Biomedical Applications". W Nanomaterials Handbook, 239–54. Second edition. | Boca Raton : Taylor & Francis, CRC Press, 2017. | Series: Advanced materials and technologies series: CRC Press, 2017. http://dx.doi.org/10.1201/9781315371795-8.

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Wu, Hong, Qianli Huang i Yanni Tan. "Carbon Nanomaterials for Biomedical Applications". W Carbon Nanomaterials, 255–93. First edition. | Boca Raton, FL : CRC Press/Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781351123587-7.

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Streszczenia konferencji na temat "Nanomaterials - Biomedical Applications"

deClaville Christiansen, Jesper, Catalina-Gabriela Potarniche, Zina Vuluga i Aleksey Drozdov. "Nanomaterials in biomedical applications". W Electronic Systems Technology (Wireless VITAE). IEEE, 2011. http://dx.doi.org/10.1109/wirelessvitae.2011.5940843.

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Urooj, Shabana, Satya P. Singh, Nidhi S. Pal i Aime Lay-Ekuakille. "Carbon-Based Nanomaterials in Biomedical Applications". W 2016 Nanotechnology for Instrumentation and Measurement (NANOfIM). IEEE, 2016. http://dx.doi.org/10.1109/nanofim.2016.8521437.

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K Rangari, Vijaya. "Nanomaterials design for engineering and biomedical applications". W Proceedings of the International Conference on Nanotechnology for Better Living. Singapore: Research Publishing Services, 2016. http://dx.doi.org/10.3850/978-981-09-7519-7nbl16-rps-303.

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Romain, Mélanie, Amira Mahmoud, Julien Boudon, Rafik Ben Chaabane, Wilfrid Boireau i Nadine Millot. "Engineered inorganic nanomaterials for biomedical and biosensing applications". W Colloidal Nanoparticles for Biomedical Applications XVIII, redaktorzy Marek Osiński i Antonios G. Kanaras. SPIE, 2023. http://dx.doi.org/10.1117/12.2648338.

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Tréguer-Delapierre, M., F. Rocco, T. Cardinal, S. Mornet, S. Vasseur i E. Duguet. "Tailor-made nanomaterials for biological and medical applications". W Biomedical Optics 2006, redaktorzy Marek Osinski, Kenji Yamamoto i Thomas M. Jovin. SPIE, 2006. http://dx.doi.org/10.1117/12.660517.

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Ekielski, Adam. "LIGNINOCELLULOSIC NANOMATERIAL AS ENVIRONMENTALLY BENIGN ALTERNATE TO TRADITIONAL NANOMATERIALS FOR BIOMEDICAL APPLICATIONS: A PERSPECTIVE". W 17th International Multidisciplinary Scientific GeoConference SGEM2017. Stef92 Technology, 2017. http://dx.doi.org/10.5593/sgem2017/61/s24.026.

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Batyuk, Liliya, Natalya Kizilova i Oksana Muraveinik. "Biomedical Applications of Nanodiamonds and Nanotoxicity Problems". W 2021 IEEE 11th International Conference Nanomaterials: Applications & Properties (NAP). IEEE, 2021. http://dx.doi.org/10.1109/nap51885.2021.9568571.

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Lodi, Matteo Bruno, i Alessandro Fanti. "Multiphysics Modeling of Magnetic Scaffolds for Biomedical Applications". W 2021 IEEE 11th International Conference Nanomaterials: Applications & Properties (NAP). IEEE, 2021. http://dx.doi.org/10.1109/nap51885.2021.9568562.

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Vecbiskena, Linda, Linda Rozenberga, Laura Vikele, Sergei Vlasov i Marianna Laka. "Bio-based nanomaterials–versatile materials for industrial and biomedical applications". W 14th International Conference on Global Research and Education, Inter-Academia 2015. Japan Society of Applied Physics, 2016. http://dx.doi.org/10.7567/jjapcp.4.011109.

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Liu, Sai. "Applications of Nanomaterials in Combined Antitumor Therapy". W ICBBS '20: 2020 9th International Conference on Bioinformatics and Biomedical Science. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3431943.3431945.

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