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Artykuły w czasopismach na temat "Nanocapsules – Toxicologie"
Chassot, Janaíne Micheli, Luana Mota Ferreira, Felipe Pereira Gomes, Letícia Cruz i Leandro Tasso. "Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions". Brazilian Journal of Pharmaceutical Sciences 51, nr 4 (grudzień 2015): 803–10. http://dx.doi.org/10.1590/s1984-82502015000400006.
Pełny tekst źródłaZielińska, Aleksandra, Filipa Carreiró, Ana M. Oliveira, Andreia Neves, Bárbara Pires, D. Nagasamy Venkatesh, Alessandra Durazzo i in. "Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology". Molecules 25, nr 16 (15.08.2020): 3731. http://dx.doi.org/10.3390/molecules25163731.
Pełny tekst źródłaCharlie-Silva, Ives, Natália Martins Feitosa, Juliana Moreira Mendonça Gomes, Daniela Chemim de Melo Hoyos, Cristiano Campos Mattioli, Silas Fernandes Eto, Dayanne Carla Fernandes i in. "Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish". PLOS ONE 15, nr 9 (24.09.2020): e0238823. http://dx.doi.org/10.1371/journal.pone.0238823.
Pełny tekst źródłaBikash Medhi, Bikash Medhi, i Dr Swayamprava Dalai. "Polymeric Nanocapsules in Drug delivery". International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, nr 4 (8.09.2022): 5933–35. http://dx.doi.org/10.37285/ijpsn.2022.15.4.1.
Pełny tekst źródłaBagale, Uday D., Shirish H. Sonawane, Bharat A. Bhanvase, Ravindra D. Kulkarni i Parag R. Gogate. "Green synthesis of nanocapsules for self-healing anticorrosion coating using ultrasound-assisted approach". Green Processing and Synthesis 7, nr 2 (25.04.2018): 147–59. http://dx.doi.org/10.1515/gps-2016-0160.
Pełny tekst źródłaBulcão, R. P., F. A. de Freitas, E. Dallegrave, M. D. Arbo, P. Zielinsky, A. R. Pohlmann, S. S. Guterres i S. C. Garcia. "Acute toxicological evaluation of lipid-core nanocapsules". Toxicology Letters 205 (sierpień 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.971.
Pełny tekst źródłaBulcão, R. P., F. A. de Freitas, C. D. G. Venturini, J. Durgante, G. Guerreiro, A. R. Pohlmann, S. S. Guterres i S. C. Garcia. "Subchronic toxicological evaluation of lipid-core nanocapsules". Toxicology Letters 205 (sierpień 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.972.
Pełny tekst źródłaMazzarino, Letícia, Ismael Casagrande Bellettini, Edson Minatti i Elenara Lemos-Senna. "Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions". Brazilian Journal of Pharmaceutical Sciences 46, nr 2 (czerwiec 2010): 219–26. http://dx.doi.org/10.1590/s1984-82502010000200008.
Pełny tekst źródłaMajda Benabbes, Aicha Fahri, Yassir El alaoui, Naoual Cherkaoui, Abdelkader Laatiris i Younes Rahali. "Formulation of parenteral nutrition based on argan oil nanocapsule system using d-optimal mixture design". International Journal of Research in Pharmaceutical Sciences 11, nr 3 (21.07.2020): 3857–65. http://dx.doi.org/10.26452/ijrps.v11i3.2567.
Pełny tekst źródłaGrandhi, Srikar, Moawia Al-Tabakha i Prameela Rani Avula. "Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine". Advances in Pharmacological and Pharmaceutical Sciences 2023 (18.11.2023): 1–16. http://dx.doi.org/10.1155/2023/8902963.
Pełny tekst źródłaRozprawy doktorskie na temat "Nanocapsules – Toxicologie"
Huang, Zhiwei. "Élaboration de polymères dérivés du poly(acide malique) pour la vectorisation ciblée de principes actifs anticancéreux". Rennes, Ecole nationale supérieure de chimie, 2011. http://www.theses.fr/2011ENCR0001.
Pełny tekst źródłaTo increase the effectiveness of drugs while reducing side effects, much research is being conducted to develop a vehicle which will be able to encapsulate drugs and release them at a specific site in the body. For this, it is necessary to design a vehicle that meets strict specifications. The vector should allow targeting of the treatment area, be stable in vivo before the release of the drug, non-toxic and biocompatible. In this context, we consider to prepare and characterize a family of nanoparticles made of degradable functional polymers belonging to the same family. We therefore synthesized, in a simple and reproducible way, six functional polymers derived from poly(malic acid), which is recognized as a biocompatible, degradable and nontoxic polymer: two hydrophobic polymers, the PMLABe and PMLAHe, and four PEGylated amphiphilic copolymers, the PEG42-b-PMLABe, PEG42-b-PMLAHe, Biot-PEG62-b-PMLABe and Biot-PEG62-b-PMLAHe. Starting from these materials, we prepared by nanoprecipitation the corresponding nanoparticles. The size of these nanoparticles ranges from 50 to 130 nm with very low polydispersity indices. In vitro cytotoxicity studies have shown that all the prepared nanoparticles were non-toxic. On the other hand, we have shown that it was possible to encapsulate up to 30wt% of doxorubicin and that this drug retained its efficacy in vitro. Finally, in vitro studies using fluorescent probe loaded nanoparticles have shown that the presence of the targeting ligand, biotin, increased the cellular uptake of PEGylated targeting nanoparticles
Delaporte, Flavien. "Évaluation de la toxicité des nanocapsules lipidiques sur des cellules hépatiques et immunitaires : influence de paramètres physico-chimiques". Electronic Thesis or Diss., Angers, 2024. https://dune.univ-angers.fr/documents/dune19058.
Pełny tekst źródłaThis PhD thesis evaluates the biodistribution and cellular toxicity of nanovectors: the lipid nanocapsules (LNCs). Physico-chemical parameters (size, charge and surface coating) can influence cellular interaction. The strong hepatic tropism of LNCs guided the first study on the evaluation of interactions between LNCs, with a diameter of 50 and 100 nm, and hepatocytes, represented by HepG2 and HepaRG cells. A relatively weak toxicity, concentration, size and time dependent was demonstrated. The 50 nm LNCs, although slower to be internalized than 100 nm ones, exhibited a higher toxicity, notably on cancer cells (HepG2 cell line). Exposure to LNCs generated lipid peroxidation which led to cells death via ferroptosis. A higher toxicity has been observed after 2 (vs. 24 h) and 4 weeks of exposure (vs. 2 weeks) for 50 nm LNCs. The 100 nm LNC seemed to be less toxic because their cytotoxicity did not increase between 2 and 4 weeks of exposure. A 2nd study allowed us to better characterized the influence of size and pegylation,parameters modified to improve blood and hepatic stealthness. LNCs of 50 and 100 nm, pegylated or not, have been exposed to human blood (ex vivo) in order to analyze the blood distribution. Circulating phagocytes (monocytes and neutrophiles) quickly internalized LNCs, without influence of size nor pegylation. An in vitro assessment was performed in order to complete the biodistribution study in hepatic cells (endotelial cell line, human macrophages and hepatocytes). It has been confirmed that LNCs preferentially distributed in liver cancer cells (vs. differentiated ones), as well as in primary human macophages and endotelial cells. Except for human macrophages, an increase in size improved internalization whereas pegylation decreased it. Finally, LNCs dit not seem to be immunomodulators. In conclusion, the passive distribution into liver cancer cells, associated with a high cytotoxicity, and the good tolerance observed with the other cells studied (hepatic in vitro and in blood ex vivo), suggest that LNCs could be considered as vectors for hepatocarcinoma treatment
Hureaux, José. "Nanocapsules lipidiques de paclitaxel et cancer bronchique : premières données d'efficacité et de toxicité chez la souris et méthodes d'aérosolisation à partir de lots précliniques". Phd thesis, Université d'Angers, 2009. http://tel.archives-ouvertes.fr/tel-00492820.
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