Gotowe bibliografie tematyczne / N - Aryl Y - Lactam

Gotowa bibliografia na temat „N - Aryl Y - Lactam”

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Data publikacji: 18 maja 2024

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Artykuły w czasopismach na temat "N - Aryl Y - Lactam"

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Tsang, Wing Y., Naveed Ahmed, Karl Hemming i Michael I. Page. "Competitive endo- and exo-cyclic C–N fission in the hydrolysis of N-aroyl β-lactams". Canadian Journal of Chemistry 83, nr 9 (1.09.2005): 1432–39. http://dx.doi.org/10.1139/v05-153.

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The balance between endo- and exo-cyclic C–N fission in the hydrolysis of N-aroyl β-lactams shows that the difference in reactivity between strained β-lactams and their acyclic analogues is minimal. Attack of hydroxide ion occurs preferentially at the exocyclic acyl centre rather than that of the β-lactam during the hydrolysis of N-p-nitrobenzoyl β-lactam. In general, both endo- and exo-cyclic C–N bond fission occurs in the alkaline hydrolysis of N-aroyl β-lactams, the ratio of which varies with the aryl substituent. Hence, the Brønsted β-values differ for the two processes: –0.55 for the ring-opening reaction and –1.54 for the exocyclic C–N bond fission reaction. For the pH-independent and acid-catalysed hydrolysis of N-benzoyl β-lactam, less than 3% of products are derived from exocyclic C–N bond fission. Key words: β-lactams, hydrolysis, linear free energy relationships, strain.
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Barba, Victor, Cecilia Hernández, Susana Rojas-Lima, Norberto Farfán i Rosa Santillan. "Preparation of N-aryl-substituted spiro-β-lactams via Staudinger cycloaddition". Canadian Journal of Chemistry 77, nr 12 (5.12.1999): 2025–32. http://dx.doi.org/10.1139/v99-212.

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The interest in the study of β-lactams continues due to their therapeutic importance as antibiotics. In this work, six spiro-β-lactams (7a-7c, 8a-8c) have been prepared using the [2+2] cycloaddition of isomaleimides to acid chlorides. The heterobicyclic structures obtained have been characterized by mass spectrometry, IR, NMR spectroscopy, and for compounds 7a, 7b, and 8b the X-ray crystallographic study showed a nearly planar arrangement for the β-lactam ring.Key words: β-lactams, azetidinone, isomaleimides, ketenes, X-ray crystallography.
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Möhrle, H., i M. Jeandrée. "Chinazolinderivate durch Cyclodehydrierung von N-(2-substituierten Aryl)-Piperidinen / Quinazoline Derivatives by Cyclodehydrogenation of N-(2-Substituted Aryl)-Piperidines". Zeitschrift für Naturforschung B 54, nr 12 (1.12.1999): 1577–88. http://dx.doi.org/10.1515/znb-1999-1217.

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Dehydrogenation of the N-[2-(aminocarbonyl)phenyl]piperidines 1 -5 using Hg(II)-EDTA, generated the quinazolinones 6 -9 . Increasing size of the 4-substituent in the piperidine decreased the oxidation rate and the product yield.N-[2-(Hydroxyiminomethyl)phenyl]piperidines 18-22 showed a different behaviour. While 18 with H g(II)-EDTA in water produced the oxime lactam 24 in quantitative yield, the 4- substituted piperidines 19-21 caused not only a lower reaction rate but also an altered product pattern. The double dehydrogenation to lactams was reduced and the cyclic nitrones, formed by two electron withdrawal, became dominant. From the spiro compounds 21 and 22, solely the quinazoline-N-oxides 29 and 30 resulted. The mechanism of the reactions is discussed.
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Fang, Zeguo, Lin Xie, Liang Wang, Qian Zhang i Dong Li. "Silver-catalyzed cascade cyclization and functionalization of N-aryl-4-pentenamides: an efficient route to γ-lactam-substituted quinone derivatives". RSC Advances 12, nr 41 (2022): 26776–80. http://dx.doi.org/10.1039/d2ra05283k.

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The synthesis of γ-lactam and related 2-oxazolidinone substituted quinone derivatives through a Ag2O-catalyzed cascade cyclization and functionalization of N-ary-4-pentenamides and N-aryl allyl carbamates has been developed.
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Saliu, Francesco, Marco Orlandi i Maurizio Bruschi. "N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines". ISRN Organic Chemistry 2012 (15.10.2012): 1–5. http://dx.doi.org/10.5402/2012/281642.

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Ozonation of N-aryl-cyclic amines in organic solvents gave N-aryl-lactams regioselectively. In particular, 4-(4-aminophenyl)-morpolin-3-one, a key intermediate in the preparation of factor Xa inhibitors, was obtained in fair yields. The method represents an alternative approach for the lactamization of tertiary N-arylic substrates and is based on a “metal-free” introduction of the carbonyl function into the heterocyclic ring.
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Haldar, Pranab, i Jayanta K. Ray. "CAN mediated decarboxylative hydroxylation/alkoxylation of N-aryl-γ-lactam-carboxylic acids at room temperature: an easy access to N-aryl-α-hydroxy/alkoxy-γ-lactams". Tetrahedron Letters 49, nr 22 (maj 2008): 3659–62. http://dx.doi.org/10.1016/j.tetlet.2008.03.147.

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Yurino, Taiga, Takeshi Ohkuma, Hamdiye Ece i Yuji Tange. "Silyl Cyanopalladate-Catalyzed Friedel–Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives". Synlett 32, nr 09 (26.01.2021): 935–39. http://dx.doi.org/10.1055/a-1373-7017.

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Abstract3-Aryloxindole derivatives were synthesized through a Friedel–Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc)2. Wide varieties of diethyl phosphates derived from N-arylmandelamides were converted almost quantitatively into oxindoles. When N,N-dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.
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Patra, Prasanta, Gandhi K. Kar, Aparna Sarkar, Jayanta K. Ray, Tista Dasgupta, Mahua Ghosh i Sugata Bhattacharya. "N-Aryl Modification in γ-Lactam: Design and Synthesis of Novel Monocyclic γ-Lactam Derivatives as Inhibitor for Bacterial Propagation". Synthetic Communications 42, nr 20 (21.06.2012): 3031–41. http://dx.doi.org/10.1080/00397911.2011.574807.

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Dorbec, Matthieu, Jean-Claude Florent, Claude Monneret, Marie-Noëlle Rager i Emmanuel Bertounesque. "1-Aryltetralin privileged structure-based libraries: parallel synthesis of N-aryl and N-biaryl γ-lactam lignans". Tetrahedron 62, nr 50 (grudzień 2006): 11766–81. http://dx.doi.org/10.1016/j.tet.2006.09.026.

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Patra, Prasanta, Gandhi K. Kar, Aparna Sarkar, Jayanta K. Ray, Tista Dasgupta, Mahua Ghosh i Sugata Bhattacharya. "ChemInform Abstract: N-Aryl Modification in γ-Lactam: Design and Synthesis of Novel Monocyclic γ-Lactam Derivatives as Inhibitor for Bacterial Propagation." ChemInform 44, nr 1 (1.01.2013): no. http://dx.doi.org/10.1002/chin.201301160.

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Rozprawy doktorskie na temat "N - Aryl Y - Lactam"

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Barman, Gopa. "Synthetic studies on N - Aryl Y - Lactam & N - Aryl Y - Thio - Lactam : chemoselective Transformation to N-Aryl-Pyrrolidine, N-Aryl Succinimide and Other Bioactive Compounds". Thesis, University of North Bengal, 2009. http://hdl.handle.net/123456789/1379.

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Bhattacharya, Biplob. "Synthesis and Anti-MRSA Activity of Hydrophilic C3-Acylated N-Thiolated β-Lactams and N-Acyl Ciprofloxacin-N-Thiolated β-Lactam Hybrids". Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4289.

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The Turos laboratory has been working with N-thiolated β-lactams for years trying to understand the mode of action and structural features it needs to have biological activity. Over the years new data has shown promising inhibitory activity against various microbes. In this dissertation, a review of the vast amount of work carried out on N-thiolated β-lactams in Turos laboratory has been done and their novelty, in terms of structure and mechanism has been discussed. A complete outline of our work in the discovery and ongoing development of these compounds, starting from our initial, unexpected finding of antimicrobial activity for one of the lead compounds, to a more complete understanding of their chemical and biological mode of action and potential utility as antibacterial compounds, has been provided. Previous researches by graduate students in the Turos laboratory have shown that N-thiolated β-lactams targets Type II Fatty Acid Synthesis (FAS). In process of understanding this further, other FAS inhibiting antibiotics like Triclosan were compared to our lactams by adding excess of exogenous fatty acids. Results revealed vast differences in the MIC value of triclosan and N-thiolated β-lactams, giving an idea that there might be a different mode of action or a different target altogether. The third chapter discusses the study of attaching hydrophilic C3 side chains like amino acids and carbohydrates on N-thiolated β-lactams while studying the influence of microbiological activity. From the study it was found that the lengthening of the side chain halts the inhibitory activity regardless of whether the side chain contains unsaturation or branching. Results showed that polar groups were not well tolerated and the inhibitory activity goes down regardless of polarity. Finally, research on dual-action antibiotics was discussed. Antibiotics cause continuous bacterial resistance and in this aspect use of two drugs with different mode of action can call for reduction of the resistance. Herein, N-acyl ciprofloxacin and N-thiolated β-lactams were connected together via an ester linkage. Six new hybrid compounds have been synthesized successfully and tested against E. faecium, K. pneumoniae, A. baumannii, P. aeruginosa, and E. cloacae.
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Bekdemir, Yunus. "The mechanisms of hydrolysis and protonation behaviour of N-aryl sultams". Thesis, University of Essex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387004.

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Dyke, Alan. "Novel Câ‚‚-symmetric N,N-donor ligands and the anionic thia-Fries rearrangement of aryl triflates". Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404435.

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Yasui, Hiroto. "Studies on Addition to 1-Aryl-1-alkynes and N-Alkynyl Amides". 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/57271.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(工学)
甲第13827号
工博第2931号
新制||工||1433(附属図書館)
26043
UT51-2008-C743
京都大学大学院工学研究科材料化学専攻
(主査)教授 大嶌 幸一郎, 教授 檜山 爲次郎, 教授 松原 誠二郎
学位規則第4条第1項該当
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Mori, Shigeki. "Studies on metallation of meso-aryl substituted hexaphyrins and N-fused pentaphyrins". 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/136922.

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Baeza, Mario Ivan. "Synthesis and characterization of acetylenic derivatives of the actinide extractant (aryl)-N,N-di-(alkyl)carbamoylmethylphosphine oxide (CMPO)". To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2008. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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Prosen, Katherine Rose. "Investigating the Mode of Action of a Novel N-sec-butylthiolated Beta-lactam Against Staphylococcus aureus". Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3609.

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N-sec -butylthioloated β-lactam (NsβL) is a novel beta-lactam antimicrobial with a mechanism of action proposed to inhibit 3-oxoacyl-acyl carrier protein synthase (ACP) III (FabH), resulting in the inhibition of fatty acid synthesis. It has been suggested that NsβL inhibits FabH indirectly by inactivating coenzyme-A (CoA). CoA is an essential cofactor for numerous proteins involved in glycolysis, the citric acid cycle (TCA), and pyruvate metabolism, in addition to fatty acid biosynthesis. This study aimed to determine the effects of NsβL on a diverse array of laboratory and clinical Staphylococcus aureus isolates by analyzing the mode of resistance in spontaneous and adaptive mutant NsβL-resistant mutants. Phenotypic analysis of the mutants was performed, as well as sequence analysis of fabH; along with comparative proteomic analysis of intracellular proteomes. Our results indicate that NsβL resistance is mediated by drastic changes in the cell wall, oxidative stress response, virulence regulation, and those pathways associated with CoA. It is our conclusion that Nsβ L has activity towards CoA, resulting in wide-spread effects on metabolism, virulence factor production, stress response, and antimicrobial resistance.
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Cui, Xiuhua. "Asymmetric hydrogenations of aryl alkenes using imidazol-2-ylidene iridium complexes". Texas A&M University, 2005. http://hdl.handle.net/1969.1/2456.

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A library of iridium complexes featuring oxazoline and imidazol-2-ylidene ligands were synthesized by reaction of a library of imidazoles with a second library of oxazoline iodides. These complexes were active catalysts for hydrogenations of aryl substituted monoenes. Tri- and 1,1-disubstituted alkenes were hydrogenated quantitatively with ee??s up to 99% at 1 atm hydrogen pressure. Catalyst, substrate, temperature and pressure effects were studied. The iridium complexes were also used for the kinetic study of hydrogenation of 2,3- diphenylbutadiene. This hydrogenation is a stepwise reaction: one double bond was hydrogenated first, then the second one. Both step hydrogenations were zero order in alkene. The consumption of 2,3-diphenylbutadiene was first order in catalyst, and probably first order in hydrogen pressure too. The enantioselectivity for the first step hydrogenation was low. There were match and mismatch catalyst-substrate relationships for the second step hydrogenation, and the enantioselectivities for this step were catalyst controlled. NMR studies indicated that the initiation of the reaction involved both hydrogen and alkene substrate. A competitive experiment was designed to explore the formation of meso-alkane at first step hydrogenation, and the results indicated that the alkane was formed predominantly via an associative mechanism. Four types of conjugate dienes were synthesized and hydrogenated. Different reactivities and selectivities were obtained for each type of dienes. In the best case, a diene was hydrogenated quantitatively with an excellent ent/meso ratio of 20:1.0 and 99% enantioselectivity. The scope, limitation and potential applications of the reactions were discussed. A selection of the dienes was hydrogenated with the Crabtree??s catalyst, for comparison, and the yields, conversions and diastereoselectivities were inferior to those from iridium-oxazoline-imidazol-2-ylidene catalysts.
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Jiao, Dezhi. "Alkyl and aryl imidazolium salts in aqueous supramolecular systems with cucurbit[n]uril". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610692.

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Książki na temat "N - Aryl Y - Lactam"

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Henderson, Colin M. Nucleophilic additions to C-aryl, N-arylsulphonyl methyleneimines. [S.l: The Author], 1992.

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Ikhlef, Fatima. Routes to 4-aryl-1-N-methylanilinobut-3-en-2-ones and reactions of 2-phenylethylamine. Salford: University of Salford, 1985.

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International Conference on Carcinogenic and Mutagenic N-Substituted Aryl Compounds (3rd 1987 Dearborn, Mich.). Carcinogenic and mutagenic responses to aromatic amines and nitroarenes: Proceedings of the Third International Conference on Carcinogenic and Mutagenic N-Substituted Aryl Compounds, held April 25-28, 1987, in Dearborn Michigan. Redaktorzy King Charles M. 1932-, Romano Louis James 1950- i Schuetzle Dennis 1942-. New York: Elsevier, 1988.

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Carcinogenic and mutagenic N-substituted aryl compounds. [Research Triangle Park, NC]: National Institutes of Health, National Institute of Environmental Health Sciences, 1994.

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Lagerman, Robert K. Metal ion induced decomposition of N-Aryl-O-pivaloylhydroxylamines in aqueous solution. 1989.

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Części książek na temat "N - Aryl Y - Lactam"

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Atwood, David A. "(IV) into N-C (Aryl) Bonds". W Inorganic Reactions and Methods, 160. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145296.ch145.

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Mitchell, Glynn, Nigel J. Barnes, John M. Cox, Ian R. Matthews, David R. Parry, David P. J. Pearson i Stephen C. Smith. "Synthesis and Structure-Activity Relationships in a Novel Class ofN-Aryl Lactam Herbicides". W ACS Symposium Series, 18–29. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2002-0800.ch003.

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Monnier, Florian, i Marc Taillefer. "Copper-Catalyzed C(aryl)–N Bond Formation". W Amination and Formation of sp2 C-N Bonds, 173–204. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/3418_2013_69.

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Kawada, Kosuke. "N-Fluoropyridinium Salt Fluorination for Preparing Aryl Fluorides". W Fluorination, 1–14. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-1855-8_40-1.

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Kawada, Kosuke. "N-Fluoropyridinium Salt Fluorination for Preparing Aryl Fluorides". W Fluorination, 1–14. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-10-1855-8_40-2.

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Kawada, Kosuke. "N-Fluoropyridinium Salt Fluorination for Preparing Aryl Fluorides". W Fluorination, 324–38. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-10-3896-9_40.

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Döpp, D., A. A. Hassan, A. M. Nour-el-Din i A. E. Mourad. "A Novel Reaction of Tetracyanoethylene with N-Aryl-Isoindolines". W Organic Free Radicals, 41–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73963-7_21.

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Nielsen, David J., i Kingsley J. Cavell. "Pd-NHC Complexes as Catalysts in Telomerization and Aryl Amination Reactions". W N-Heterocyclic Carbenes in Synthesis, 73–102. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/9783527609451.ch4.

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Juliano, Luiz, Maria Helena S. Cezari i Regina S. H. Carvalho. "Studies on lactam formation during the coupling procedures with N α-carbobenzoxy-N G-tosylarginine". W Peptides 1992, 247–48. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_99.

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Bartsch, Richard A., David A. Babb i Brian E. Knudsen. "Synthesis and Alkali Metal Cation Complexation of N-Aryl [3.2.2] Cryptands". W Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts, 407–11. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3987-5_67.

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Streszczenia konferencji na temat "N - Aryl Y - Lactam"

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Liu, Chang, Jing Zhu, Wei Huang, Jin Xu, Changgui Lu i Yiping Cui. "Quadratic nonlinear optical properties of N-aryl stilbazolium dyes". W Nonlinear Optics: Technologies and Applications. SPIE, 2007. http://dx.doi.org/10.1117/12.757577.

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Ścianowski, Jacek, Agata Pacuła i Magdalena Obieziurska. "N-aryl benzisoselenazolones – synthesis, transformations and antioxidant activity". W The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a019.

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KOIKE, R., J. MOTOYOSHIYA i H. AOYAMA. "THE HIGH ENERGY KEY INTERMEDIATES IN THE PEROXYOXALATE CHEMILUMINESCENCE OF 2,4,6-TRICHLOROPHENYL N-ARYL-N-TOSYLOXAMATES". W Proceedings of the 13th International Symposium. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812702203_0037.

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Chaves, Humberto T., Ana M. Lobo, Sundaresan Prabhakar i Henry S. Rzepa. "A theoretical mechanistic investigation of asymmetric aziridination by N-Aryl-O-acylhydroxylamines." W The first European conference on computational chemistry (E.C.C.C.1). AIP, 1995. http://dx.doi.org/10.1063/1.47868.

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Pindjakova, Dominika, Lucia Vrablova, Tomas Strharsky, Jiri Kos i Josef Jampilek. "Investigation of Interactions of ortho- and para-N-Aryl-Substituted 2-Trifluoromethylcinnamanilides". W ECSOC-25. Basel Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecsoc-25-11651.

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Cieślak, Jacek, Jadwiga Jankowska, Michał Sobkowski, Annika Kers, Inger Kers, Jacek Stawinski i Adam Kraszewski. "The reactions of aryl nucleoside H-phosphonates with O-, N-, and S-nucleophiles". W XIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902063.

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Ridzuan, M. S. M., M. Z. Jaafar i M. M. Zain. "Quantitative structure-activity relationship (QSAR) modelling of N-aryl derivatives as cholinesterase inhibitors". W 2012 IEEE Symposium on Humanities, Science and Engineering Research (SHUSER). IEEE, 2012. http://dx.doi.org/10.1109/shuser.2012.6269006.

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Gonec, Tomas, Lucia Vrablova, Dominika Pindjakova, Tomas Strharsky, Michal Oravec i Josef Jampilek. "Preparation and Hydro-Lipophilic Properties of Monosubstituted N-Aryl-4-hydroxyquinoline-3-carboxanilides". W International Electronic Conference on Synthetic Organic Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecsoc-26-13548.

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Keung Chui, Wai, Anton Dolzhenko i Hriday Bera. "Synthesis of N-(3(5)-Aryl-1,2,4-triazol-5(3)-yl)-N'-carbethoxythioureas and Their Tautomerism in DMSO Solution". W The 13th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00187.

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Palermo, Mark G., Rohan Beckwith, Christopher S. Straub, Kara Herlihy, Yiping Shen, Xiaolu Zhang, Matthew Clapham i Brian Hurley. "Abstract C54: Aryl-N-(1H-imidazol-2-yl)-acetamides: Nonpeptidic binders of Bir3 cIAP protein." W Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-c54.

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Możesz być także zainteresowany rozszerzonymi bibliografiami na temat „N - Aryl Y - Lactam” dla poszczególnych typów źródeł:
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