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Rozprawy doktorskie na temat „Muscle stem cell”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 stycznia 2025

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1

Woodhouse, Samuel. "The role of Ezh2 in adult muscle stem cell fate." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610201.

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Theret, Marine. "Cell and non-cell autonomous regulations of metabolism on muscle stem cell fate and skeletal muscle homeostasis." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB120/document.

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A l’état basal, les cellules souches musculaires sont quiescentes. Après blessure, ces cellules s’activent, s’amplifient et se différencient afin de réparer les myofibres lésées. Cependant, une petite population de ces cellules myogéniques activées ne va pas entrer dans la voie de la myogenèse, mais va retourner en quiescence par un phénomène appelé auto-renouvellement. Cette étape est cruciale afin de maintenir une réserve de cellules souches musculaires tout au long de la vie. Mais, les mécanismes cellulaires et moléculaires régulant ce phénomène sont peu décrits dans la littérature. La régé

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Wang, Yu Xin. "Molecular Regulation of Muscle Stem Cell Self-Renewal." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35207.

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Muscle stem cells self-renew to maintain the long-term capacity for skeletal muscles to regenerate. However, the homeostatic regulation of muscle stem cell self-renewal is poorly understood. By utilizing high-throughput screening and transcriptomic approaches, we identify the critical function of dystrophin, the epidermal growth factor receptor (EGFR), and fibronectin in the establishment of cell polarity and in determining symmetric and asymmetric modes of muscle stem cell self-renewal. These findings reveal an orchestrated network of paracrine signaling that regulate muscle stem cell homeost

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4

Victor, Pedro Sousa. "Skeletal muscle aging: stem cell function and tissue homeostasis." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/81933.

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Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in geriatric individuals undergoing sarcopenia. The age-associated muscle wasting is also associated with a decline in regenerative ability and a reduction in resident muscle stem cell (satellite cell) number and function. Although sarcopenia is one of the major contributors to the general loss of physiological function, the mechanisms involved in age-related loss of muscle homeostasis and satellite cell activity are yet poorly understood. Using a microarray-based tran

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Richards-Malcolm, Sonia Angela. "THE ROLE OF STEM CELL ANTIGEN-1(Sca-1) IN MUSCLE AGING." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_theses/519.

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Muscle aging is associated with a decrease in the number of satellite cells and their progeny, muscle progenitor cells (MPCs) that are available for muscle repair and regeneration. However, there is an increase in non-immuno-hematopoietic cells (CD45 negative) in regenerating muscle from aged mice characterized by high stem cell antigen -1(Sca-1) expression. In aged regenerating muscle, 14.2% of cells are CD45neg Sca-1pos while 7.2% of cells are CD45neg Sca-1pos in young adult muscle. In vitro, CD45neg Sca-1pos cells over express genes associated with fibrosis, potentially controlled by Wnt2.

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Feige, Peter. "Molecular Regulation of Satellite Cell Fate." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40804.

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Muscle homeostasis and regeneration are complex cellular processes orchestrated by muscle stem cells and their interaction with their stem cell microenvironment. The fate of a muscle stem cell is influenced by different conditions such as muscle injury, cold stress, or disease. During extensive muscle repair and in the context of muscular dystrophy, we identified the critical function of the Epidermal Growth Factor Receptor (EGFR) in establishing cell polarity and in turn the efficient formation of myogenic progeny able to repair muscle. Using a novel drug screen, we identified the p53 protein

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7

Pannerec, Alice. "The skeletal muscle stem cell niche : defining hierarchies based upon the stem cell marker PW1 to identify therapeutic target cells." Paris 6, 2012. http://www.theses.fr/2012PA066440.

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Les cellules satellites permettent la réparation des muscles squelettiques, mais chez les patients atteints de myopathies ces cellules ne fonctionnent pas correctement ce qui conduit à l’atrophie musculaire. Nos travaux ont montré qu’une nouvelle population de cellules souches musculaires, les PICs, favorisent la prolifération des cellules satellites par l’intermédiaire de la follistatine qui contrebalance l’effet négatif de la myostatine. Lorsque la myostatine est inactivée chez des souris par injection d’inhibiteur, le nombre de PICs augmente considérablement et les animaux présentent des mu

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8

Pannérec, Alice. "The skeletal muscle stem cell niche : defining hierarchies based upon the stem cell marker PW1 to identify therapeutic target cells." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00833422.

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Les cellules satellites permettent la réparation des muscles squelettiques, mais chez les patients atteints de myopathies ces cellules ne fonctionnent pas correctement ce qui conduit à l'atrophie musculaire. Nos travaux ont montré qu'une nouvelle population de cellules souches musculaires, les PICs, favorisent la prolifération des cellules satellites par l'intermédiaire de la follistatine qui contrebalance l'effet négatif de la myostatine. Lorsque la myostatine est inactivée chez des souris par injection d'inhibiteur, le nombre de PICs augmente considérablement et les animaux présentent des mu

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9

Cahill, Kevin Scott. "Enhancement of stem-cell transplantation strategies for muscle regeneration." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0002319.

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Zhang, Ting [Verfasser]. "Epigenetic regulation of muscle stem cell expansion / Ting Zhang." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1076980325/34.

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Geiger, Ashley Elizabeth. "Impacts of dietary obesity on muscle stem cell behaviors." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/87757.

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Occurrence of obesity has steadily increased in the human population and, along with it, associated health complications such as systemic insulin resistance, which can lead to the development of type 2 diabetes mellitus. Obesity is a complex metabolic disorder that often leads to chronic inflammation and an overall decline in human and animal health. In mouse skeletal muscle, obesity has been shown to impair muscle regeneration after injury, however, the mechanism underlying these changes in satellite cell (SC) biology have yet to be explored. To test the negative impacts of obesity on SC b

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12

PAVLIDOU, THEODORA. "Perturbation of muscle stem cell differentiation by small molecules." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/201951.

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Skeletal muscle is one of the most important and plastic tissues of our body. Damaged or stressed skeletal muscle undergoes biological repair and formation of new myofibers upon regeneration signals that activate a complex cross talk between heterogeneous populations of muscle mononucleate cells. The result of this dynamic interplay is the activation of a specialized population of myogenic progenitors, the satellite cells (SCs). Satellite cells are mitotically quiescent and upon activation by regenerative signals they can divide asymmetrically and give rise to myogenic cells (myoblasts) that p

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13

Collins, Charlotte Anne. "An investigation of the stem cell potential of skeletal muscle satellite cells." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446604/.

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Satellite cells are defined by their position beneath the basal lamina of myofibres, and are a source of new myonuclei in adult skeletal muscles. However, other phenotypes also contribute to muscle regeneration, and the relative importance of satellite cells is not known. This work aimed to analyse the stem cell potential of satellite cells by formally investigating their contribution to muscle regeneration. Myofibres isolated from extensor digitorum longus, soleus, and tibialis anterior muscles were found to have respective means of 7,22 and 10 associated satellite cells. When a single myofib

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14

Kahatapitiya, Prathibha C. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs a paradigm for enhanced stem cell transplantation /." Connect to full text, 2008. http://hdl.handle.net/2123/4050.

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Thesis (Ph. D.)--University of Sydney, 2009.<br>Title from title screen (viewed Apr. 24, 2008) Title from title screen (viewed Feb. 18, 2009) Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Paediatrics and Child Health, Faculty of Medicine. Degree awarded 2009 ; thesis submitted 2008. Includes bibliographical references. Also available in print form.

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Benavente, Diaz Maria. "Investigation of the molecular diversity defining muscle stem cell heterogeneity." Electronic Thesis or Diss., Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2020SORUS072.pdf.

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Le muscle squelettique adulte a une capacité de régénération remarquable, pouvant guérir après des traumatismes répétés. Cette propriété dépend de la présence de cellules souches musculaires (SCMu), qui sont pour la plupart quiescentes dans des conditions homéostatiques mais qui s'activent après une blessure, réintègrent le cycle cellulaire et prolifèrent pour donner naissance à des myoblastes qui fusionneront pour restaurer les fibres endommagées. De nombreuses études ont étudié les états transitoires que les SCMu empruntent de l'entrée du cycle cellulaire à la différenciation. Malgré le fait

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Kahatapitiya, Prathibha Chathurani. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/4050.

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The BCNU + O6benzylguanine (O6BG) driven selective enrichment strategy was first established for enhanced transplantation of hematopoietic stem cells. This study describes a novel application of this BCNU + O6BG driven selective enrichment strategy in skeletal muscle stem cell transplantation. Furthermore, this study addresses the three main limitations observed in previously reported skeletal muscle stem cell transplantation strategies. Limitation of ineffective donor cells which lack the ability for successful engraftment was overcome by using a heterogeneous population of donor cells which

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Kahatapitiya, Prathibha Chathurani. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs." University of Sydney, 2009. http://hdl.handle.net/2123/4050.

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Doctor of Philosophy (PhD)<br>The BCNU + O6benzylguanine (O6BG) driven selective enrichment strategy was first established for enhanced transplantation of hematopoietic stem cells. This study describes a novel application of this BCNU + O6BG driven selective enrichment strategy in skeletal muscle stem cell transplantation. Furthermore, this study addresses the three main limitations observed in previously reported skeletal muscle stem cell transplantation strategies. Limitation of ineffective donor cells which lack the ability for successful engraftment was overcome by using a heterogeneous po

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18

Piccoli, Martina. "Mouse amniotic fluid stem cells are able to differentiate into satellite cells replenishing the depauperated muscle stem cell niche." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423564.

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Introduction: Stem cell biology has received much interest because of its potential in both therapeutic application and in vitro modeling of diseases. In particular embryonic stem cells have good proliferative and differentiative abilities, but their use is still associated to ethical concerns and problems related to their teratogenic potential. Adult stem cells have also been described to be pluripotent both in vitro and in vivo. However, their use is limited because they are difficult to isolate and expand, particularly in a clinical setting. In this scenario, it would be advantageous to obt

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Yin, Xiaoke. "Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells." Thesis, Queen Mary, University of London, 2006. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1764.

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Embryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process. Mouse ES cells are pre-differentiated by withdrawal of the leukemia inhibitory factor-1 from the culture medium. Subsequently, stem cell antigen-1 positive (Sca-1) cells are sorted by magnetic labelling cell sorting with anti-Sca-1 microbeads and cultured in differentiation medium with or without platelet-derived growth factor (PDGF). Protein extracts of ES cells and Sca-1+ cell

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Thumiah-Mootoo, Madhavee. "The Role of Mitophagy in Muscle Stem Cell Fate and Function During Muscle Regeneration." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42239.

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Skeletal muscles have a remarkable capacity to repair and regenerate in response to injury by virtue of their unique population of resident muscle stem cells (MuSCs). Recently, several studies have reported that mitochondria are important regulators of fate and function in various types of stem cells including MuSCs. Furthermore, emerging evidence has shown that accumulation of dysfunctional mitochondria leads to stem cell aging, premature commitment and impaired self-renewal. Preliminary evidence from publicly available transcriptomics datasets processed by our lab showed that Phosphatase and

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21

Goel, Aviva J. "Niche Regulation of Muscle Stem Cell Quiescence by Classical Cadherins." Thesis, Icahn School of Medicine at Mount Sinai, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10743988.

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<p> Many adult stem cells are characterized by prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is necessary for successful repair. Non-physiological breaks in quiescence often lead to stem cell depletion and impaired tissue restoration. Here, I identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells; SCs) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC

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22

Berti, Federica. "Protection of the muscle stem cell state from premature differentiation." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/protection-of-the-muscle-stem-cell-state-from-premature-differentiation(6886509a-35fa-43b1-8971-7cb2dcaa7da3).html.

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The extraordinary capacity of regeneration exists in just certain species and tissue types. Invertebrates, the cells that regenerate tissues are called stem cells. During adulthood, damaged muscle tissue regenerates through Satellite stem cells that re-enter the cell cycle from a quiescent state, giving rise to new muscle tissue. During development, newly forming organisms build tissues through proliferating stem cells that renew the stem cell pool whilst generating myogenic stem cells which will eventually differentiate into muscle cells. For many years the Myogenic Regulatory Factors (Mrf) g

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Yu, Xiaotian. "Functional impact of microRNA-34a on stem cell differentiation towards smooth muscle cell." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9121.

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MicroRNAs play an important role in biological regulation. Recently miR-34a has been reported to regulate tumour cell cycle progression and apoptosis. However, the functional role of miR-34a in smooth muscle cell (SMC) differentiation from stem cells is yet unclear. Main objectives of this PhD project are to determine the functional role of miR-34a and its target genes in SMC differentiation and underlying mechanisms. Mouse embryonic stem (ES) cells were seeded on collagen coated flasks in differentiation medium to allow SMC differentiation. Upon analysis, miR-34a was significantly up-regulate

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Yeo, Wendy Wai Yeng. "Differentiation of skeletal muscle-derived stem cells into beta pancreatic lineage." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS091.

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Le diabète de type 1 (DT1) est caractérisé par des niveaux élevés de glucose en raison de la destruction des cellules ß pancréatiques sécrétrices d'insuline. Cependant, les thérapies actuelles de remplacement des cellules bêta du pancréas impliquant la transplantation d'îlots pancréatiques sont techniquement difficiles et limitées par la disponibilité de don d'organes. Bien que les cellules souches embryonnaires et les cellules souches pluripotentes induites soient intensément étudiées, aucune de ces deux sources de cellules souches ne peut être utilisée directement sans le risque de développe

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Swaminathan, Ganesh. "Evaluation Of Adult Stem Cell Derived Smooth Muscle Cells For Elastic Matrix Regenerative Repair." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1462209321.

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Ruan, Travis. "Identification of Terminal Differentiation Enhancers in Human Embryonic Stem Cell Derived Skeletal Muscle Cells." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27257.

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Skeletal myogenesis is a tightly coordinated process resulting from the temporal expression of signalling cascades that specify myogenic cell fate. Identification of signalling pathways and small molecules that can modulate this developmental process, continues to be an active area of research. Utilising the pluripotent nature of human embryonic stem cells (hESC) and combined with next generation sequencing, we demonstrate our in vitro skeletal muscle differentiation system accurately recapitulate major skeletal muscle developmental process. We show myotubes formation can be further enhanced u

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Pasut, Alessandra. "Regulation of Muscle Stem Cell Function by the Transcription Factor Pax7." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32448.

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Pax7 is a paired box transcription factor expressed by all satellite cells which are critically required for muscle regeneration and growth. The absolute requirements of Pax7 in the maintenance of the satellite cell pool are widely acknowledged. However the mechanisms by which Pax7 executes muscle regeneration or contributes to satellite cell homeostasis remain elusive. We performed cell and molecular analysis of Pax7 null satellite cells to investigate muscle stem cell function. Through genome wide studies, we found that genes involved in cell cell interactions, regulation of migration, contr

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Baker, Nicole. "Muscle Stem Cell Fate is Directed by the Mitochondrial Fusion Protein OPA1." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41974.

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During aging there is a decline in (MuSCs) and muscle regeneration, though the underlying reason is unknown. Interestingly, mitochondrial fragmentation is a common feature in aging, however, how this impacts MuSC function and maintenance has not been investigated. To address the effect of mitochondrial fragmentation in MuSCs, we generated a knockout mouse model using the Pax7CreERT2 inducible system to target deletion of the mitochondrial fusion protein Opa1 specifically within MuSCs (Opa1-KO). Analysis of MuSC function following muscle injury revealed a defect in the regenerative potential of

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Schabort, Elske Jeanne. "The effect of TGF-[beta] isoforms on progenitor cell recruitment and differentiation into cardiac and skeletal muscle /." Link to the online version, 2007. http://hdl.handle.net/10019.1/1295.

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Tan, Kah Yong. "Stem Cell-Based Strategies to Enhance Muscle Regeneration through Extrinsic and Intrinsic Regulators." Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10009.

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Skeletal muscle has a remarkable capacity for regeneration, mediated by muscle stem cells that can self-renew or differentiate to form the mature myofibers of the tissue. Several human diseases are characterized by a loss of function and strength in skeletal muscle, with impairments in the ability to regenerate and consequent decreases in quality of life and increases in mortality. The work in this dissertation has focused on developing methods for combating muscle disease. This goal has been approached through attempts at cell replacement therapy - by generating muscle cells that can be engra

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Steele-Stallard, Heather. "Induced pluripotent stem cell platforms for disease modelling of skeletal muscle laminopathies." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10058072/.

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Laminopathies are a clinically and genetically heterogeneous group of 16 disorders caused by mutations in LMNA. This gene codes for lamin A and lamin C, which together with lamin B1 and B2 form the nuclear lamina, a mesh-like structure located underneath the inner nuclear membrane. Laminopathy disorders show striking tissue specificity, with subtypes affecting striated muscle, peripheral nerve, and others causing multisystem disease with accelerated aging. The exact mechanisms underlying the pathology of laminopathies, and the cause of the tissue specific phenotypes are unknown, although sever

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Fittipaldi, R. "ROLE OF SMYD3 IN SKELETAL MUSCLE ATROPHY AND MOUSE EMBRYONIC STEM CELL." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/238009.

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Epigenetic regulation of gene expression plays a pivotal role in the establishment of developmental programs and the maintenance of the differentiated state. Among the different actors involved in this scenery, the modifications of histones tail are implicated with the propagation of gene expression patterns. Our group is focused on SMYD3, a histone-methyltransferase which is reported to be is highly expressed in normal conditions only in the embryo, in adult skeletal muscle and in few other tissues. In light of SMYD3 restricted expression, we asked whether it might play a role during myogene

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Harutiun, Minas Nalbandian Geymonat. "Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265184.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23412号<br>医博第4757号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)特定拠点教授妻木範行, 教授戸口田淳也, 教授松田秀一<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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Kocharyan, Avetik. "Derivation and Characterization of Pax7 Positive Skeletal Muscle Precursor Cells from Control and HGPS-derived induced Pluripotent Stem Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37517.

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Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder associated with premature aging in various tissues and organs of the afflicted individuals, including accelerated skeletal muscle atrophy. Classical HGPS manifests due to single-base substitution in the LAMNA gene which encodes Lamin A/C proteins. As a result of the mutation, a truncated form of Lamin (known as Progerin) is produced which undergoes persistent farnesylation during post-translational modification. Accumulation of Progerin in the nucleus has been linked to various cellular abnormalities including abnormal nucl

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Ding, Can. "The influence of Notch over-stimulation on muscle stem cell quiescence versus proliferation, and on muscle regeneration." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066399/document.

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La transplantation de cellules souches de muscle possède un grand potentiel pour la réparation à long terme du muscle dystrophique. Cependant, la croissance ex vivo des cellules souches musculaires réduit de manière significative l'efficacité de leur greffe puisque le potentiel myogénique est considérablement réduit lors de la mise en culture. La voie de signalisation Notch a émergé comme un régulateur majeur des cellules souches musculaires (MuSCs) et il a également été décrit que la sur-activation de Notch est crucial pour le maintien du caractère souche des MuSC. Cette découverte pourrait ê

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Ding, Can. "The influence of Notch over-stimulation on muscle stem cell quiescence versus proliferation, and on muscle regeneration." Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066399.

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La transplantation de cellules souches de muscle possède un grand potentiel pour la réparation à long terme du muscle dystrophique. Cependant, la croissance ex vivo des cellules souches musculaires réduit de manière significative l'efficacité de leur greffe puisque le potentiel myogénique est considérablement réduit lors de la mise en culture. La voie de signalisation Notch a émergé comme un régulateur majeur des cellules souches musculaires (MuSCs) et il a également été décrit que la sur-activation de Notch est crucial pour le maintien du caractère souche des MuSC. Cette découverte pourrait ê

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Li, Xiang. "Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/58260.

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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent airflow limitation that is not fully reversible and is usually caused by cigarette smoke (CS). The disease is predicted to be the fourth leading cause of death by 2030, but none of the currently available treatments can alleviate the progressive decline in lung function. Mesenchymal stem cells (MSCs) are fibroblast-like multipotent stem cells that can be isolated from various tissues such as bone marrow (BM-MSCs). Despite numerous reports of their efficacy in COPD-related pre-clinical mod

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Zhou, Lili. "The role of Lasp in the «Drosophila» male stem cell niche and in muscle development." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95064.

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Drosophila Lasp is the only member of the nebulin family in Drosophila. Lasp has an amino-terminal LIM domain, two actin-binding nebulin repeats and a carboxyl-terminal SH3 domain and exhibits very high homology to human Lasp. To assess Lasp function in vivo, we generated a null mutant in Drosophila Lasp, named Lasp1. Lasp1 mutants are homozygous viable, but male sterile. Lasp localizes to cyst cells, early germ cells, hub cells and actin cones. In Lasp1 mutants, the stem cell niche is no longer anchored to the apical tip of the testis, and actin cone migration is perturbed resulting in improp

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Luk, Hui Ying. "Effect of the Resistance Exercise-Induced Hormonal Changes on Satellite Cell Myogenic State." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1157528/.

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Skeletal muscle satellite cells are important for muscle repairing and muscle mass growth. For a successful muscle regenerative process, satellite cells have to sequentially undergoing different stages of myogenic process, i.e. proliferative state and differentiation state. To support this process, the presence of different circulating factors, such as immune cells, cytokines, and hormones, at the appropriate time course is critical. Among these factors, hormones, such as testosterone, cortisol, and IGF-1, have shown to play an important role in satellite cell proliferation and differentiation

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Neal, A. "Satellite cell subpopulations and environmental mediators of their function : implications for stem cell therapy in skeletal muscle." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383594/.

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Satellite cells are myogenic cells found between the basal lamina and the sarcolemma of the muscle fibre (myofibre). Satellite cells are the source of new myofibres; as such, satellite cell transplantation holds promise as a treatment for muscular dystrophies. There is a need to investigate factors that enable satellite cell survival and/or proliferation post engraftment in order to obtain the optimal donor cell and host environment for efficient satellite cell transplantation. I have investigated sex differences in mouse satellite cell populations across the lifespan in vitro and in vivo. I s

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Mademtzoglou, Despoina. "Coordinating growth arrest and myogenesis in muscle stem cells : a molecular and cellular analysis." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066231/document.

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Ce travail de thèse a porté sur l'étude de l'équilibre entre la prolifération et la différenciation dans le cadre de la myogenèse embryonaire et postnatale. Chez l'embryon, le sortie du cycle cellulaire est contrôlé par p57 et p21 pendant la myogenèse. Nous avons montré que la voie de signalisation Notch ainsi que les facteurs de régulation myogéniques (MRFs) régulent l'expression de p57 dans les cellules progénitrices et les myoblastes en différentiation. Chez l'adulte, p21 et p57 ne sont pas exriés dans la population quiescente de cellules souches du muscle (cellules satellites - SCs). p21 e

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Lý, Hà My. "Characterization of a novel molecular pathway linking metabolic regulation and muscle stem cell fate." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10193.

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Le muscle strié squelettique possède une capacité de régénération grâce à une population de cellules souches musculaires (CSM ou cellules satellites) qui gardent une capacité à exprimer un programme myogénique lors d'une lésion musculaire. Une perte de la capacité myogénique des CSM est associée à la perte musculaire avec l'âge, mais aussi à des maladies invalidantes telles que les myopathies. Une des caractéristiques de la fonction des CSMs est leur plasticité métabolique qui supporte le programme myogénique. Sur la base de travaux antérieurs du laboratoire mettant en évidence le rôle central

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Pala, Francesca. "Metabolic characterisation of skeletal muscle stem cells in distinct physiological states." Electronic Thesis or Diss., Paris 6, 2017. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2017PA066607.pdf.

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Les cellules souches musculaires, ou cellules satellites, adoptent différents états en transitant de quiescence à prolifération et différentiation. Ces transitions s'accompagnent de variations des demandes énergétiques. Il demeure cependant incertain comment la modulation du métabolisme énergétique peut dicter la spécification d'un état cellulaire donné. Mon projet de thèse a eu pour objectif principal la caractérisation des voies du métabolisme énergétique à l’œuvre dans les différents états cellulaires, et comment leur modulation peut influencer ces états. Nous montrons ainsi que les cellule

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Pala, Francesca. "Metabolic characterisation of skeletal muscle stem cells in distinct physiological states." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066607/document.

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Les cellules souches musculaires, ou cellules satellites, adoptent différents états en transitant de quiescence à prolifération et différentiation. Ces transitions s'accompagnent de variations des demandes énergétiques. Il demeure cependant incertain comment la modulation du métabolisme énergétique peut dicter la spécification d'un état cellulaire donné. Mon projet de thèse a eu pour objectif principal la caractérisation des voies du métabolisme énergétique à l’œuvre dans les différents états cellulaires, et comment leur modulation peut influencer ces états. Nous montrons ainsi que les cellule

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Mademtzoglou, Despoina. "Coordinating growth arrest and myogenesis in muscle stem cells : a molecular and cellular analysis." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066231.pdf.

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Ce travail de thèse a porté sur l'étude de l'équilibre entre la prolifération et la différenciation dans le cadre de la myogenèse embryonaire et postnatale. Chez l'embryon, le sortie du cycle cellulaire est contrôlé par p57 et p21 pendant la myogenèse. Nous avons montré que la voie de signalisation Notch ainsi que les facteurs de régulation myogéniques (MRFs) régulent l'expression de p57 dans les cellules progénitrices et les myoblastes en différentiation. Chez l'adulte, p21 et p57 ne sont pas exriés dans la population quiescente de cellules souches du muscle (cellules satellites - SCs). p21 e

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Rigon, Matteo [Verfasser], and Rüdiger [Akademischer Betreuer] Rudolf. "Stem cell-induced regeneration of skeletal muscle tissue: characterization of a glycerol-induced muscle damage model / Matteo Rigon ; Betreuer: Rüdiger Rudolf." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1227585527/34.

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Girardi, Francesco. "TGFbeta signalling pathway in muscle regeneration : an important regulator of muscle cell fusion." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS114.

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La régénération musculaire s’appuie sur une réserve de cellules souches résidant dans le muscle appelées cellules satellites (MuSCs). Les MuSCs sont quiescentes et peuvent s’activer à la suite d’une blessure du muscle afin de former des progéniteurs amplificateurs (myoblastes) qui se différencieront et fusionneront pour former de nouvelles myofibres. Durant ce processus, un réseau complexe de voies de signalisation est impliqué, parmi lequel la signalisation du facteur de croissance transformant bêta (TGFβ) joue un rôle fondamental. Précédents rapports ont proposé de nombreuses fonctions pour

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Libergoli, Michela. "CD90 marks satellite cells into two subpopulations with distinct dynamics of activation and proliferation." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/323156.

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Previous work from our laboratory in the mdx mouse model of Duchenne muscular dystrophy (DMD) demonstrated that a fraction of muscle stem cells (i.e., satellite cells) (MuSCs) progressively lose the expression of myogenic markers during the progression of the disease. In the process of characterizing this aberrant behaviour, we serendipitously discovered that MuSCs might be separated into two distinct subpopulations based on the expression of the GPI-anchored surface protein CD90. Crucially, this separation does not correlate with a divergence from the myogenic lineage; instead, it separates t

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Hori, Shimpei. "PDH-mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice." Kyoto University, 2019. http://hdl.handle.net/2433/245311.

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Awaya, Tomonari. "Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells." Kyoto University, 2013. http://hdl.handle.net/2433/180602.

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