Gotowe bibliografie tematyczne / Multipotency

Gotowa bibliografia na temat „Multipotency”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 20 lutego 2023

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Artykuły w czasopismach na temat "Multipotency"

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Mrksich, Milan. "Multipotency retained". Nature Materials 10, nr 8 (22.07.2011): 559–60. http://dx.doi.org/10.1038/nmat3086.

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Istiaq, Arif, i Kunimasa Ohta. "Ribosome-Induced Cellular Multipotency, an Emerging Avenue in Cell Fate Reversal". Cells 10, nr 9 (1.09.2021): 2276. http://dx.doi.org/10.3390/cells10092276.

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The ribosome, which is present in all three domains of life, plays a well-established, critical role in the translation process by decoding messenger RNA into protein. Ribosomal proteins, in contrast, appear to play non-translational roles in growth, differentiation, and disease. We recently discovered that ribosomes are involved in reverting cellular potency to a multipotent state. Ribosomal incorporation (the uptake of free ribosome by living cells) can direct the fate of both somatic and cancer cells into multipotency, allowing them to switch cell lineage. During this process, both types of cells experienced cell-cycle arrest and cellular stress while remaining multipotent. This review provides a molecular perspective on current insights into ribosome-induced multipotency and sheds light on how a common stress-associated mechanism may be involved. We also discuss the impact of this phenomenon on cancer cell reprogramming and its potential in cancer therapy.
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Ismail, A. A., S. Wagner, H. Murua Escobar, S. Willenbrock, K. A. Sterenczak, M. T. Samy, A. M. Abd El-Aal, I. Nolte i P. Wefstaedt. "Effects of High-Mobility Group A Protein Application on Canine Adipose-Derived Mesenchymal Stem CellsIn Vitro". Veterinary Medicine International 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/752083.

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Multipotency and self-renewal are considered as most important features of stem cells to persist throughout life in tissues. In this context, the role of HMGA proteins to influence proliferation of adipose-derived mesenchymal stem cell (ASCs) while maintaining their multipotent and self-renewal capacities has not yet been investigated. Therefore, extracellular HMGA1 and HMGA2 application alone (10–200 ng/mL) and in combination with each other (100, 200 ng/mL each) was investigated with regard to proliferative effects on canine ASCs (cASCs) after 48 hours of cultivation. Furthermore, mRNA expression of multipotency marker genes in unstimulated and HMGA2-stimulated cASCs (50, 100 ng/mL) was analyzed by RT-qPCR. HMGA1 significantly reduced cASCs proliferation in concentrations of 10–200 ng/mL culture medium. A combination of HMGA1 and HMGA2 protein (100 and 200 ng/mL each) caused the same effects, whereas no significant effect on cASCs proliferation was shown after HMGA2 protein application alone. RT-qPCR results showed that expression levels of marker genes including KLF4, SOX2, OCT4, HMGA2, and cMYC mRNAs were on the same level in both HMGA2-protein-stimulated and -unstimulated cASCs. Extracellular HMGA protein application might be valuable to control proliferation of cASCs in context with their employment in regenerative approaches without affecting their self-renewal and multipotency abilities.
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Teng, Chiao-Fang, Long-Bin Jeng i Woei-Cherng Shyu. "Role of Insulin-like Growth Factor 1 Receptor Signaling in Stem Cell Stemness and Therapeutic Efficacy". Cell Transplantation 27, nr 9 (8.06.2018): 1313–19. http://dx.doi.org/10.1177/0963689718779777.

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Evidence has emerged that stem cells represent a promising therapeutic tool for tissue engineering and regenerative medicine. Thus, identifying functional markers for selecting stem cells capable of superior self-renewal and pluripotency (or multipotency) and maintaining stem cell identity under appropriate culture conditions are critical for guiding the use of stem cells toward clinical applications. Many investigations have implicated the insulin-like growth factor 1 receptor (IGF1R) signaling in maintenance of stem cell characteristics and enhancement of stem cell therapy efficacy. IGF1R-expressing stem cells display robust pluripotent or multipotent properties. In this review, we summarize the essential roles of IGF1R signaling in self-renewal, pluripotency (or multipotency), and therapeutic efficacy of stem cells, including human embryonic stem cells, neural stem cells, cardiac stem cells, bone marrow mesenchymal stem cells, placental mesenchymal stem cells, and dental pulp mesenchymal stem cells. Modifying IGF1R signaling may thus provide potential strategies for maintaining stem cell properties and improving stem-cell-based therapeutic applications.
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Miceli, Vitale, Mariangela Pampalone, Serena Vella, Anna Paola Carreca, Giandomenico Amico i Pier Giulio Conaldi. "Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems". Stem Cells International 2019 (18.02.2019): 1–16. http://dx.doi.org/10.1155/2019/7486279.

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The secretion of potential therapeutic factors by mesenchymal stem cells (MSCs) has aroused much interest given the benefits that it can bring in the field of regenerative medicine. Indeed, the in vitro multipotency of these cells and the secretive capacity of both angiogenic and immunomodulatory factors suggest a role in tissue repair and regeneration. However, during culture, MSCs rapidly lose the expression of key transcription factors associated with multipotency and self-renewal, as well as the ability to produce functional paracrine factors. In our study, we show that a three-dimensional (3D) culture method is effective to induce MSC spheroid formation, to maintain the multipotency and to improve the paracrine activity of a specific population of human amnion-derived MSCs (hAMSCs). The regenerative potential of both 3D culture-derived conditioned medium (3D CM) and their exosomes (EXO) was assessed against 2D culture products. In particular, tubulogenesis assays revealed increased capillary maturation in the presence of 3D CM compared with both 2D CM and 2D EXO. Furthermore, 3D CM had a greater effect on inhibition of PBMC proliferation than both 2D CM and 2D EXO. To support this data, hAMSC spheroids kept in our 3D culture system remained viable and multipotent and secreted considerable amounts of both angiogenic and immunosuppressive factors, which were detected at lower levels in 2D cultures. This work reveals the placenta as an important source of MSCs that can be used for eventual clinical applications as cell-free therapies.
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Juliano, C. E., S. Z. Swartz i G. M. Wessel. "A conserved germline multipotency program". Development 137, nr 24 (23.11.2010): 4113–26. http://dx.doi.org/10.1242/dev.047969.

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Xie, Meng, Dmitrii Kamenev, Marketa Kaucka, Maria Eleni Kastriti, Baoyi Zhou, Artem V. Artemov, Mekayla Storer i in. "Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish". Proceedings of the National Academy of Sciences 116, nr 30 (8.07.2019): 15068–73. http://dx.doi.org/10.1073/pnas.1900038116.

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Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton.
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Malvicini, Ricardo, Diego Santa-Cruz, Natalia Pacienza i Gustavo Yannarelli. "OCT4 Silencing Triggers Its Epigenetic Repression and Impairs the Osteogenic and Adipogenic Differentiation of Mesenchymal Stromal Cells". International Journal of Molecular Sciences 20, nr 13 (3.07.2019): 3268. http://dx.doi.org/10.3390/ijms20133268.

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Mechanisms mediating mesenchymal stromal/stem cells’ (MSCs) multipotency are unclear. Although the expression of the pluripotency factor OCT4 has been detected in MSCs, whether it has a functional role in adult stem cells is still controversial. We hypothesized that a physiological expression level of OCT4 is important to regulate MSCs’ multipotency and trigger differentiation in response to environmental signals. Here, we specifically suppressed OCT4 in MSCs by using siRNA technology before directed differentiation. OCT4 expression levels were reduced by 82% in siOCT4-MSCs, compared with controls. Interestingly, siOCT4-MSCs also presented a hypermethylated OCT4 promoter. OCT4 silencing significantly impaired the ability of MSCs to differentiate into osteoblasts. Histologic and macroscopic analysis showed a lower degree of mineralization in siOCT4-MSCs than in controls. Moreover, OCT4 silencing prevented the up-regulation of osteoblast lineage-associated genes during differentiation. Similarly, OCT4 silencing resulted in decreased MSC differentiation potential towards the adipogenic lineage. The accumulation of lipids was reduced 3.0-fold in siOCT4-MSCs, compared with controls. The up-regulation of genes engaged in the early stages of adipogenesis was also suppressed in siOCT4-MSCs. Our findings provide evidence of a functional role for OCT4 in MSCs and indicate that a basal expression of this transcription factor is essential for their multipotent capacity.
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Swartz, S. Zachary, Celina E. Juliano, Tal Raz, Doron Lipson, Patrice Milos, Amro Hamdoun i Gary M. Wessel. "An ancient molecular circuit specifying multipotency". Developmental Biology 344, nr 1 (sierpień 2010): 514–15. http://dx.doi.org/10.1016/j.ydbio.2010.05.368.

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Rahnama, Ruyan, i Challice L. Bonifant. "Engineering builds multipotency for iPSC-NKs". Blood 140, nr 23 (8.12.2022): 2414–16. http://dx.doi.org/10.1182/blood.2022017794.

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Rozprawy doktorskie na temat "Multipotency"

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Wetzig, Andrew R., i n/a. "Olfactory Stem Cells From Adult Rats". Griffith University. School of Biomolecular and Biomedical Science, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070724.121953.

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The formation of neurospheres was important in demonstrating that neurogenesis in the adult brain may be fuelled by a stem cell population. The olfactory mucosa is another site of neurogenesis which, in humans, has been observed to contain a stem cell population through the formation of neurospheres (Murrell et al., 2005). Stem cells can be defined as cells capable of self-renewal and multipotency. The aim of this study was to investigate the potential of rat olfactory stem cells growing as neurospheres. The hypothesis is that the rat olfactory mucosa contains a 'true' stem cell population that can be cultured as neurospheres and that will demonstrate multipotency by differentiating into 'non-olfactory' cell types and possess the capacity for self-renewal, if provided with the appropriate environmental niche. Here it was found that adult rat olfactory mucosa is capable of generating neurospheres when cultured in EGF and bFGF. Evidence of self-renewal was provided by the formation of six generations of neurospheres, the formation of neurospheres from single cells and the expression of markers associated with self-renewal by neurosphere cells. The multipotency of olfactory neurosphere cells was demonstrated through manipulation of the stem cell niche. In defined culture conditions, extracellular matrix molecules and growth factors were able to induce the differentiation of neurosphere cells down the dopaminergic lineage pathway. When co-cultured with differentiating cells, neonatal myoblasts and 3T3-L1 cells, olfactory neurosphere cells were able to differentiate and incorporate into a skeletal muscle myotube and differentiate into adipocytes, respectively. In conclusion it was found that the adult rat olfactory mucosa is capable of generating neurospheres. When presented with an appropriate niche neurosphere cells are able to self-renew and demonstrate multipotency.
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Wetzig, Andrew R. "Olfactory Stem Cells From Adult Rats". Thesis, Griffith University, 2007. http://hdl.handle.net/10072/366121.

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The formation of neurospheres was important in demonstrating that neurogenesis in the adult brain may be fuelled by a stem cell population. The olfactory mucosa is another site of neurogenesis which, in humans, has been observed to contain a stem cell population through the formation of neurospheres (Murrell et al., 2005). Stem cells can be defined as cells capable of self-renewal and multipotency. The aim of this study was to investigate the potential of rat olfactory stem cells growing as neurospheres. The hypothesis is that the rat olfactory mucosa contains a 'true' stem cell population that can be cultured as neurospheres and that will demonstrate multipotency by differentiating into 'non-olfactory' cell types and possess the capacity for self-renewal, if provided with the appropriate environmental niche. Here it was found that adult rat olfactory mucosa is capable of generating neurospheres when cultured in EGF and bFGF. Evidence of self-renewal was provided by the formation of six generations of neurospheres, the formation of neurospheres from single cells and the expression of markers associated with self-renewal by neurosphere cells. The multipotency of olfactory neurosphere cells was demonstrated through manipulation of the stem cell niche. In defined culture conditions, extracellular matrix molecules and growth factors were able to induce the differentiation of neurosphere cells down the dopaminergic lineage pathway. When co-cultured with differentiating cells, neonatal myoblasts and 3T3-L1 cells, olfactory neurosphere cells were able to differentiate and incorporate into a skeletal muscle myotube and differentiate into adipocytes, respectively. In conclusion it was found that the adult rat olfactory mucosa is capable of generating neurospheres. When presented with an appropriate niche neurosphere cells are able to self-renew and demonstrate multipotency.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Faculty of Science
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Wuidart, Aline. "Defining the mechanisms regulating the switch from multipotency to unipotency during mammary gland development". Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/264618.

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Les cellules souches assurent le développement des tissus, leur renouvellement ainsique leur réparation suite à des blessures. L’une des questions clés du domaine de labiologie des cellules souches est l’identification des différents types cellulaires qu’unecellule souche peut donner. Les cellules souches peuvent être multipotentes, c’est-à-direcapables de donner naissance à plusieurs types cellulaires différents, ou unipotentes,c’est-à-dire qu’elles ne peuvent alors se différencier qu’en un seul type cellulaire. Lesexpériences de traçage cellulaire sont réalisées quotidiennement en biologie dudéveloppement et en biologie des cellules souches afin d’évaluer le devenir des cellulessouches in vivo. Cependant, il n’existe à ce jour aucune méthode rigoureuse permettantd’interpréter les résultats d’expériences de traçage cellulaire de manière non ambigüe etde déterminer la multipotence ou l’unipotence des cellules souches avec grande précisionet de manière statistiquement fiable. Nous avons développé de nouvelles méthodes afind’évaluer avec une très grande précision le caractère unipotent ou multipotent descellules souches du sein et de la prostate. Ces nouvelles découvertes démontrent demanière non ambigüe que la prostate provient de cellules souches multipotentes, alorsque seules des cellules souches unipotentes contribuent au développement et auremodelage de la glande mammaire au stade adulte. D’autre part, nous montrons que cesont des cellules souches multipotentes qui sont responsables des phases précoces dudéveloppement embryonnaire de la glande mammaire, et que ces cellules deviennentunipotentes peu avant la naissance. Nous avons étudié les mécanismes régulant le passagede l’état multipotent à l’état unipotent et démontrons que le facteur de transcription p63joue un rôle crucial dans la restriction du potentiel de différenciation des cellules souchesmammaires embryonnaires. Enfin, nous montrons que les cellules souches mammairesadultes, normalement unipotentes, peuvent redevenir multipotentes en conditionsphysiopathologiques telles que l’ablation spécifique d’une lignée cellulaire mammaire ouau cours de l’initiation tumorale. Nous essayons donc de comprendre de manière généraleles mécanismes impliqués dans le passage de l’état unipotent à l’état multipotent descellules souches mammaires adultes, et d’élucider les similarités existant entre lesdifférentes conditions dans lesquelles des cellules souches mammaires multipotentessont observées.
Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished
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McMurray, Rebecca Jane. "Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency". Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3042/.

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The discovery of stem cells has led to rapid advances in the field of regenerative medicine. Their unique properties, including the ability to self-renew and differentiate make them ideal for the repair/replacement of tissues that have been damaged as a result of disease or injury. Mesenchymal stem cells in particular represent a highly valuable pool of adult stem cells for such regenerative applications due to their accessibility, and potential as an autologous patient derived autologous nature However current methods for the in vitro expansion of high quality autologous mesenchymal stem cells results in spontaneous differentiation of the stem cell population and a loss of differentiation capacity over time. In vivo, it is the stem cell niche that provides stem cells with the appropriate cues required to maintain stem cell self-renewal. It is proposed that by mimicking these cues using biomaterials, that the self-renewal of mesenchymal stem cells can be controlled in vitro. In this study, a novel nanopit topography was investigated for its effects on the maintenance and growth of mesenchymal stem cells in vitro. To investigate this, three main aspects of mesenchymal stem cell state were examined in response to this novel nanotopography: maintenance of the stem cell phenotype over time including expression of stem cell markers and differentiation potential over time, changes in signalling pathways associated with differentiation and lastly, the metabolic profile of stem cells. As a result of this study we have identified a novel nanopit topography, which in the absence of chemical supplements, provides a substrate that is conducive to the maintenance of mesenchymal stem cells. Small RNAs have also been implicated in the regulation of signalling pathways and the metabolic state of stem cells. Furthermore, the ability to produce nanotopographically-patterned substrates using current standard techniques provides an inexpensive, high throughput method for the production of novel tissue culture plastics suitable for the maintenance of mesenchymal stem cells.
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Gray, Simon Matthew. "PRC2-Mediated H3K27me3 Repression Promotes Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency". Thesis, Yale University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10584947.

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Elucidating how multipotent memory precursor (MP) cells maintain developmental plasticity and longevity to provide long-term immunity while most effector cells develop into terminally differentiated effector (TE) cells with limited survival is necessary for understanding immunological memory formation. We profiled active (H3K27Ac) and repressed (H3K27me3) chromatin states in naïve, MP and TE CD8+ T cells during viral infection, and observed increased H3K27me3 at numerous pro-memory and pro-survival genes in TE relative to MP cells, indicative of fate restriction, but permissive chromatin at both pro-memory and pro-effector genes in MP cells, indicative of multipotency. Deficiency in PRC2-mediated H3K27me3 deposition impaired clonal expansion and TE cell differentiation, but minimally impacted memory cell maturation. Abundant H3K27me3 deposition at pro-memory genes occurred relatively late during TE cell development in a FOXO1-regulated manner. These results outline a detailed temporal model for how effector T cells lose memory cell potential through selective epigenetic-silencing of pro-memory genes.

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Cwinn, Matthew. "'Suppressor of fused' antagonizes hedgehog signaling and is required to maintain retinal progenitor cell identity and multipotency". Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28214.

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The mature retina consists of six neuronal and one glial cell type that are derived from a pool of mulipotent progenitor cells (RPC). The decision to remain as a multipotent progenitor or to specify a particular retinal cell lineage and differentiate are governed by cell intrinsic and extrinsic factors. Sonic hedgehog (Shh) is a secreted lipoprotein that is motigenic for RPCs and influences cell fate decisions. Suppressor of fused (Sufu) is an intracellular antagonist of the pathway; however, its role in regulating Shh signaling and influencing cell fate decisions in RPCs are unknown. Here, I demonstrate that Sufu antagonizes the Hh pathway in RPCs both in vitro and in vivo. Surprisingly, Sufu was required to maintain early RPC identity and multipotency. Conditional deletion of Sufu in early RPCs resulted in the down-regulation of transcription factors required to maintain RPC identity and multipotency as well as transcription factors required to specify all seven retinal cell types.Sufu-null RPCs were incapable of differentiating into the normal complement of retinal cell types and instead differentiated into restricted subsets of interneurons. These data demonstrate that Sufu antagonizes the Hh pathway in RPCs and provides novel evidence that Sufu is required for proper progenitor cell behavior.
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Chang, Eun Hyuk. "The role of polycomb repressive complex 2 in postnatal subventricular zone neural stem/progenitor cell self-renewal and multipotency". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1ddbd108-0256-4a4a-b40a-35818197ca39.

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The murine subventricular zone (SVZ) in a brain contains a population of stem cells and daily produces tens of thousands of neurons throughout lifetime. However, the mechanisms of SVZ neural stem/progenitor cell (NSPC) maintenance, differentiation and cell-fate specification are still not clear. To understand these parameters via histone methylations with bivalent mechanism, the SVZ NSPCs were first isolated by using a culture technique called neurosphere assay (NSA). It has been a challenge to culture pure cell populations of SVZ subtypes, so the NSA was initially validated. The H3K27me3 mark, which has a dominant role in the bivalent mechanism, has not been studied in postnatal and adult SVZ in vivo, yet their role has been implicated to control the shift of embryonic cortical neurogenesis to gliogenesis. Therefore, we have first investigated whether H3K27me3 marks are present in the postnatal and adult SVZ NSPC population and whether their marks have been changed after stroke or demyelination in central nervous system (CNS) by immunohistrochemistry. With the confirmation of H3K27me3 mark present in SVZ NSPCs, the presence of H3K27me3 catalyzer, called polycomb repressive complex 2 (PRC2) core components (Eed, Ezh2, Suz12) including Jarid2, was investigated and confirmed in postnatal SVZ in vitro by qRT-PCR and Western blot. To understand the role of PRC2 enzymatic activity in postnatal SVZ neurosphere self-renewal and multipotency, Eed was down-regulated by using lentiviral mediated delivery of shRNA. Also, PRC2 dependent or independent function of Jarid2 was examined via knockdown approach. The lack of Eed in the neurospheres resulted the attenuation of self-renewal and oligodendrogenesis, whereas the Jarid2 knockdown neurospheres showed the decreased proliferation with no SVZ NSPC differentiation. Based on these knockdown studies, it suggests Eed and Jarid2 might not share their function in the postnatal SVZ NSPCs to govern postnatal SVZ NSPC self-renewal and multipotency.
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Kole, Denis. "Role of Fibroblast Growth Factor 2 in Maintenance of Multipotency in Human Dermal Fibroblasts Treated with Xenopus Laevis Egg Extract Fractions". Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/207.

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Current usage of human embryonic stem cells (hES) and induced pluripotent stem cells (iPS) in clinical therapies and personalized medicine are limited as a result of ethical, technical and medical problems that arise from isolation and generation of these cells. Isolation of hES cells faces ethical problems associated with their derivation from human pre-implantation embryos. The most controversial aspect of hES cell isolation targets the generation of autologous hES cell lines which requires the transfer of a somatic-cell nucleus from the patient to an enucleated oocyte. While already established embryonic stem cell lines from IVF embryos can be used in a similar manner, lack of genetic identity can cause therapy rejection from the host, and prevent their use in personalized medicine. Induced pluripotent stem cells on the other hand, are generated from somatic cells that have been reprogrammed in vitro to behave like stem cells. While these cells can potentially be used for personalized medicine without the risk of rejection by the host system, derivation methods prevent their therapeutic use. The most efficient method used to generate iPS cells involves usage of viral particles which can result in viral DNA being integrated in the host cell’s genome and render these cells non-compliant for clinical therapies. Other methods not involving viral particles exist as well, but the reprogramming efficiency is too low and technical problems with generating large enough numbers of cells prevent these methods from being feasible approaches for clinical therapies. Direct reprogramming of a differentiated cell into a developmentally more plastic cell would offer alternatives to applications in regenerative medicine that currently depend on either embryonic stem cells (ES), adult stem cells or iPS cells. We hypothesize that Xenopus laevis egg cytoplasmic extract contains critical factors needed for reprogramming that may allow for non-viral, chemically defined derivation of human induced pluripotent/multipotent cells which can be maintained by addition of exogenous FGF2. In this thesis we investigated a new method for generation of multipotent cells through determining the ability of select fractions of Xenopus laevis egg extract to induce multipotency in already differentiated cells. We were able to identify select fractions from the extract that in combination with exogenously added FGF2 can reprogram and maintain the reprogrammed cells in an undifferentiated state. The findings of this work also determined that Xenopus laevis egg extract mRNA is required for achieving full reprogramming. The body of work presented in this thesis showed the ability of FGF2 isoforms to bind and activate select FGF receptor tyrosine kinases, act as extracellular mitogenic factors to support growth of hES cells in an undifferentiated state as well bind to nuclear DNA and affect expression of endogenous genes. Moreover, we showed that all FGF2 isoforms can induce expression of stem cell specific proteins in human dermal fibroblasts as well as extend lifespan of human dermal fibroblasts in vitro. In this work we identified HECW1, the gene coding for E3 ubiquitin ligase NEDL1, as a novel nuclear target for all FGF2 isoforms and showed that overexpression of recombinant FGF2 isoforms in human dermal fibroblasts can down regulate expression of HECW1 gene.
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Philip, Diana Liz. "The Influence of Synthetic Microenvironments in Determining Stem Cell Fate". University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1627669247178055.

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Loison-Robert, Ludwig. "Cellule souche gingivale : origine et multipotence". Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0083/document.

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La gencive correspond à un modèle de régénération naturelle grâce notamment à sa capacité de cicatrisation « ad integrum ». Ce phénomène est permis par sa composition en fibroblastes gingivaux. Ces cellules, composante cellulaire principale du tissu conjonctif gingival, sont au cœur de la régulation des réponses inflammatoires et de la cicatrisation. Ce tissu contient, comme d’autres tissus mésenchymateux, des cellules souches ; qui expliquent en partie ces capacités de régénération. De plus, comme le tissu gingival est abondant et facilement accessible, l’utilisation de ces cellules souches pourraient être d’un intérêt prometteur en thérapie cellulaire ou pour de la modélisation in vitro. Au cours de cette thèse, nous avons pu montrer que les Cellules Souches dérivées de la Gencive Humaine (CSGH) possèdent des propriétés communes avec les cellules souches adultes dérivées des crêtes neurales. Ces cellules peuvent être qualifiées de « souche » par leur capacité d’auto-renouvèlement, d’adhésion au plastique et de multipotence. Premièrement, nous avons montré que la méthode ainsi que les produits de culture utilisés pour l’isolation des fibroblastes gingivaux in vitro à partir de biopsies de gencive avait une influence sur les cellules obtenues. Dans un second temps, une analyse clonale in vitro de populations de fibroblastes gingivaux a permis de montrer que les fibroblastes gingivaux sont composés de sous-populations qui expriment des marqueurs spécifiques des cellules souches et des crêtes neurales. Outre leur origine embryologique, l’étude de leur multipotence a aussi été caractérisée après expansion et en fonction des additifs utilisés. Pour finir, deux exemples d’utilisation de ces cellules comme modèle d’étude de la biocompatibilité de biomatériaux in vitro ont été développés; imitant la muqueuse buccale ainsi que les réactions dentaires (réparatrices et réactionnaire)
Gingiva is a natural regeneration model thanks to its "ad integrum" healing capability. Gingival fibroblasts are the main actors of this property. These cells, the main cellular component of the gingival connective tissue, regulate the inflammatory responses and healing process. This tissue contains, like many others, mesenchymal stem cells; which also partly explain these regenerative abilities. Moreover, as the gingiva is abundant and easily accessible, the use of these stem cells may interest cell therapy or in vitro model tissues responses. In this work, we demonstrated that Stem Cells Derived from Human Gingiva (SCHG) have common properties with neural crest adult stem cells. These cells can be called "stem cells" for their ability to self-renew, adhere to plastic and to differentiate. First, we have shown that the method and the culture products used for isolation of gingival fibroblasts from gingival biopsy had an influence on the obtained cells. Secondly, an analysis of in vitro clonal populations of gingival fibroblasts has shown that gingival fibroblasts are composed of subpopulations that express specific markers of stem cells and neural crests. In addition to their embryological origin, the study of their multipotency was also characterized after expansion and depending on the used additives. Finally, two examples of using these cells and dental pulp stem cells as a model to study the in vitro biocompatibility of biomaterials have been developed, mimicking oral mucosa or dentin reactions (reparative or reactional)
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Książki na temat "Multipotency"

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Harrison, Andrew James. Evidence of multipotency in immortalised cells derived from bone marrow stroma. Manchester: University of Manchester, 1996.

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Hoffman, Robert M., red. Multipotent Stem Cells of the Hair Follicle. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3786-8.

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Bamba, Shigeki. Gut stem cells: Multipotent, clonogenic, and the origin of gastrointestinal cancer. New York: Nova Science Publishers, 2008.

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Pearson, Mark Andrew. Investigation of molecular mechanisms involved in cytokine synergy in multipotent haemopoietic cells. Manchester: University of Manchester, 1996.

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Reynolds, Brent A., i Loic P. Deleyrolle. Neural progenitor cells: Methods and protocols. New York: Humana Press, 2013.

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Amit, M., i Joseph Itskovitz-Eldor. Atlas of human pluripotent stem cells: Derivation and culturing. New York: Humana Press, 2012.

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Hoffman, Robert M. Multipotent Stem Cells of the Hair Follicle: Methods and Protocols. Springer New York, 2016.

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Hoffman, Robert M. Multipotent Stem Cells of the Hair Follicle: Methods and Protocols. Springer New York, 2018.

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Reynolds, Brent A., i Loic P. Deleyrolle. Neural Progenitor Cells: Methods and Protocols. Humana Press, 2016.

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Deleyrolle, Loic P. Neural Progenitor Cells: Methods and Protocols. Springer, 2021.

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Części książek na temat "Multipotency"

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Zipori, Dov. "Multipotency and Tissue-Specific Stem Cells". W Biology of Stem Cells and the Molecular Basis of the Stem State, 39–55. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-130-1_2.

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Teng, Yang D., Serdar Kabatas, Jianxue Li, Dustin R. Wakeman, Evan Y. Snyder i Richard L. Sidman. "Functional Multipotency of Neural Stem Cells and Its Therapeutic Implications". W Perspectives of Stem Cells, 255–70. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3375-8_16.

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Teng, Yang D., Xiang Zeng, Inbo Han i Jaime E. Anderson. "Neural Stem Cells: Functional Multipotency and Spinal Cord Injury Research Protocols". W Working with Stem Cells, 311–29. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30582-0_18.

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Jiang, Fang-Xu, i Grant Morahan. "Pancreas-Derived Multipotent Progenitors". W Regenerative Medicine - from Protocol to Patient, 345–62. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27610-6_13.

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Wolfe, Margaret, Alan Tucker, Roxanne L. Reger i Darwin J. Prockop. "Multipotent Stromal Cells (hMSCs)". W Human Adult Stem Cells, 45–72. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2269-1_2.

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Verfaillie, Catherine M. "Multipotent Adult Progenitor Cells: An Update". W Stem Cells: Nuclear Reprogramming and Therapeutic Applications, 55–65. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470091452.ch5.

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Postovit, Lynne-Marie, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E. B. Seftor i Mary J. C. Hendrix. "Plasticity Underlying Multipotent Tumor Stem Cells". W Stem Cells and Cancer, 99–112. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-933-8_8.

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Motohashi, Tsutomu, i Takahiro Kunisada. "Melanoblasts as Multipotent Cells in Murine Skin". W Skin Stem Cells, 257–66. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/7651_2018_144.

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Motohashi, Tsutomu, i Takahiro Kunisada. "Melanoblasts as Multipotent Cells in Murine Skin". W Skin Stem Cells, 183–92. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-330-5_15.

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Zhao, Weian, Debanjan Sarkar, James Ankrum, Sean Hall, Weili Loh, Wei Suong Teo i Jeffrey M. Karp. "Therapeutic Applications of Mesenchymal Stem/Multipotent Stromal Cells". W Stem Cells & Regenerative Medicine, 195–218. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-860-7_12.

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Streszczenia konferencji na temat "Multipotency"

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Trella, Emanuele. "Abstract A016: Multipotency of a CD40L-expressing recombinant vaccinia virus". W Abstracts: Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 25-28, 2016; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6066.imm2016-a016.

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Van Dyke, William S., Ozan Akkus i Eric Nauman. "Murine Osteochondral Stem Cells Express Collagen Type I More Strongly on PDMS Substrates Than on Tissue Culture Plastic". W ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14272.

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The discovery of the multipotent lineage of mesenchymal stem cells has dawned a new age in tissue engineering, where an autologous cell-seeded scaffold can be implanted into different therapeutic sites. Mesenchymal stem cells have been reported to differentiate into numerous anchorage-dependent cell phenotypes, including neurons, adipocytes, myoblasts, chondrocytes, tenocytes, and osteoblasts. A seminal work detailing that mesenchymal stem cells can be directed towards differentiation of different cell types by substrate stiffness alone [1] has led to numerous studies attempting to understand how cells can sense the stiffness of their substrate [2–3] Substrate stiffness has been shown to be an inducer of stem cell differentiation. MSCs on extremely soft substrates (250 Pa), similar to the stiffness of bone marrow, became quiescent but still retained their multipotency [4]. Elastic substrates in the stiffness range of 34 kPa revealed MSCs with osteoblast morphology, and osteocalcin along with other osteoblast markers were expressed [1]. However, osteogenesis has been found to increase on much stiffer (20–80 kPa) [5–6] (400 kPa) [7] as well as much softer substrates (75 Pa) [8]. Overall, cells have increased projected cell area and proliferation on stiffer substrates, leading to higher stress fiber formation. This study seeks to understand if the stiffness of the substrate has any effect on the differentiation potential of osteochondral progenitor cells into bone cells, using an in vitro dual fluorescent mouse model.
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Kolosova, Irina, Daniel J. Angelini, Chunling Fan, John Skinner i Roger A. Johns. "Hypoxia-Induced Mitogenic Factor Stimulates Proliferation And Migration Maintaining The Multipotency Of Mesenchymal Stem Cells". W American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1238.

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Kosak, Oliver, Felix Bohn, Felix Keller, Hella Ponsar i Wolfgang Reif. "Ensemble Programming for Multipotent Systems". W 2019 IEEE 4th International Workshops on Foundations and Applications of Self* Systems (FAS*W). IEEE, 2019. http://dx.doi.org/10.1109/fas-w.2019.00037.

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Yuan, Lin, Naoya Sakamoto, Guanbin Song i Masaaki Sato. "Migration of Human Mesenchymal Stem Cells is Stimulated by Low Shear Stress via MAPK Signaling". W ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80056.

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Mesenchymal stem cells (MSCs) represent as multipotent stem cells which hold the abilities of self-renewal and give rise to cells of diverse lineages [1]. With their remarkable combination of multipotent differentiation potential and low immunogenicity, MSCs are considered to be an attractive candidate for cell-based tissue repair and regenerative tissue engineering [2, 3]. Increasing number of studies has demonstrated that mobilization and migration of injected MSCs to the damaged tissues is a key step for these cells to participate in disease treatment and tissue regeneration [4, 5].
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Serdukov, Yu V., А. Yu Adamovich, V. K. Shadrina i D. B. Nizheharodava. "THE COMPARISON OF MULTIPOTENT MESENCHYMAL STROMAL CELLS IN DONORS OF DIFFERENT AGE GROUPS". W SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-111-114.

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The morpho-functional characteristics (viability, sterility, immunophenotype, proliferative and differentiation potential, immunosuppressive properties) of multipotent mesenchymal stromal cells obtained from donors of different age groups are presented in this work.
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Svirskaya, A. V., M. A. Yakauleva, D. B. Nizheharodava i M. M. Zafranskaya. "EFFECT OF HYPOXIA ON IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT MESENCHYMAL STROMAL CELLS". W SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-2-94-97.

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This study characterizes the effect of hypoxia on human multipotent mesenchymal stromal cells ability to modulate mitogen-stimulated proliferation of peripheral blood mononuclear cells, what can be used for optimization of biomedical cell products protocols using for cell therapy of pathological conditions accompanied by hypoxia.
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Tsao, Chia-Wen, Meng-Zhi Chiang i Yu-Che Cheng. "Effects of Chemical and Physical Shear-Stress Stimulation of Human Placenta-Derived Multipotent Stem Cells in Microchannel". W ASME 2013 11th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icnmm2013-73194.

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Multipotent cells obtain from human postpartum term placenta is an ethically conductive, easily accessible and high-yielding stem cell source. In this conference presentation, we demonstrate using microchannel platform to culture and differentiate the human placenta-derived stem cells. Both chemical and shear stress stimulation effects were investigated.
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Abdelalim, Essam, Idil Aigha, Ahmed Elsayed i Bushra Memon. "Generation of a Novel Population of Pancreatic Multipotent Progenitor Cells Expressing NKX61". W Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2018. http://dx.doi.org/10.5339/qfarc.2018.hbpd291.

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Abdelalim, Essam, Idil I. Aigha, Ahmed K. Elsayed i Bushra Memon. "Generation of a Novel Population of Pancreatic Multipotent Progenitor Cells Expressing NKX61". W Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2018. http://dx.doi.org/10.5339/qfarc.2018.hbpp291.

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Raporty organizacyjne na temat "Multipotency"

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Selsted, Michael E. Structure and Design of Multipotent Peptide Microbicides. Fort Belvoir, VA: Defense Technical Information Center, sierpień 1988. http://dx.doi.org/10.21236/ada199085.

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Wilson, Cindy A. Signaling from a Novel Receptor Tyrosine Kinase and the Control of Multipotent Mammary Progenitor Cells. Fort Belvoir, VA: Defense Technical Information Center, wrzesień 2006. http://dx.doi.org/10.21236/ada492622.

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