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Kagdi, Huzefa H. "Mining Software Repositories to Support Software Evolution". Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1216149768.
Pełny tekst źródłaSogbadji, Robert. "Neutronic study of the mono-recycling of americum in PWR and of the core conversion INMNSR using the MURE code". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00843688.
Pełny tekst źródłaSilva, Ana Paula Ramão da. "Imagens do mar nas crônicas de Rubem Braga". Universidade Estadual de Londrina. Centro de Letras e Ciências Humanas. Programa de Pós-Graduação em Letras, 2005. http://www.bibliotecadigital.uel.br/document/?code=vtls000109865.
Pełny tekst źródłaThe research comes from a curious look about the constant presence of the sea in Rubem Braga's chronicles. From this, we tried to understand the reason of these images and their possible meanings. To make the deal, it was necessary to start investigating the particularities of the chronicle while modern literary genre, as well as its origin and fixation in Brazil and the language characteristics. In other moment, we needed to find out how the sea was built as a symbolical element in the western world, so then to observe its recurrences in literary works that are important in the cultural universe. After these stages, the images of the sea were analyzed in Braga's chronicles in a dialogue with the ones studied in other works.
Nerman, Isabell, i Jesper Andersson. "Rättelse i fastighetsregistrets inskrivningsdel : Kan det vara mer rätt att rätta mer?" Thesis, KTH, Fastigheter och byggande, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298021.
Pełny tekst źródła19 ch. 22 § in the Land Code (Sw: jordabalken) stipulates that if the land register section of the Real Property Register contains an obvious inaccuracy which depends on the land registration authority or somebody else's clerical error, similar inadvertence or due to a technical error, the land registration authority shall correct the inaccuracy. Regarding this regulation, the purpose of this master’s thesis is to establish the law (de lege lata), analyse the necessary conditions and propose rule changes (de lege ferenda) whether correction could be applied in more situations than what is possible today. Beyond the traditional sources of law, empirical material consisting of lower court praxis, decisions from the Parliamentary ombudsmen and interview material are included. Also, the regulations regarding correction according to 36 § of the Administrative Procedure Act (Sw: förvaltningslagen (2017:900)) and 4 ch. 21 § of the Floating Charges Act (Sw: lag (2008:990) om företagshypotek) are presented as a basis for a concluding comparison. From the conclusion – for instance – it appears that 19 ch. 22 § of the Land Code has a restrictive interpretation, which means that only incorrections that in a clear way fulfil the necessary conditions can be corrected. If correction would be applied in more situations, it is important that the individual legal rights should not be compromised since a third party can suffer loss after relying on information in the register that later will be corrected.
Bjureland, William. "Analysis of deep excavations using the mobilized strength design(MSD) method". Thesis, KTH, Jord- och bergmekanik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-136584.
Pełny tekst źródłaLeydold, Josef, Gerhard Derflinger, Günter Tirler i Wolfgang Hörmann. "An Automatic Code Generator for Nonuniform Random Variate Generation". Department of Statistics and Mathematics, Abt. f. Angewandte Statistik u. Datenverarbeitung, WU Vienna University of Economics and Business, 2001. http://epub.wu.ac.at/364/1/document.pdf.
Pełny tekst źródłaSeries: Preprint Series / Department of Applied Statistics and Data Processing
Ferreira, Guadalupe Estrelita dos Santos Menta. "O universo simbólico na viagem de Mãe, materno mar : nos trilhos do imaginário bantu". Universidade Estadual de Londrina. Centro de Letras e Ciências Humanas. Programa de Pós-Graduação em Letras, 2011. http://www.bibliotecadigital.uel.br/document/?code=vtls000161472.
Pełny tekst źródłaThis research aims, by means of the literature, to recognize elements of the African culture, particularly in Angola, whose signs of the Bantu matrix are present in the formation of the Brazilian culture. The chosen corpus, Mãe, Materno Mar, by Boaventura Cardoso, unrolls the threads of the narrative, where modernity and tradition dialogue, having especially in the Bantu imaginary this interlocutory process with the memory of the people, allowing the persistence of tradition and affirmation of an identity suppressed by the colonialist oppression for such a long time. The peculiarities of the Bantu culture in its religious aspects, and the symbolic universe that pervades the narrative provide the basis for the understanding of connections among the unconscious and the imaginary and the memory of the Angolan people. As this is a work in which history is transformed into an allegorical journey into the microcosm of the Angolan society, a committed literature is found, but admittedly art, whose commitment to its writing in process permits retelling the story of its people, perhaps reviving the hopes that were eventually dispersed along the way.
Braga, Patrícia Benedita Aparecida. "A grande casa no fundo do mar : Tuvalu e os impasses políticos ambientais contemporâneos". Universidade Estadual de Londrina. Centro de Letras e Ciências Humanas. Programa de Pós-Graduação em Ciências Sociais, 2012. http://www.bibliotecadigital.uel.br/document/?code=vtls000178987.
Pełny tekst źródłaTaking into account that global climate change is a reality and that its causes are related to anthropogenic as well as to Earth's own dynamics, we can say that today, after 1989, the resolutions of a group of researchers belonging to the Intergovernmental Panel about Climate Change (IPCC) based scientific data that are used in global political actions at local, regional and global levels, are reshaping and influencing social and economic changes everywhere. The affirmative scientific environmental and climate change are embedded on one political context of global actions characterized by power asymmetry, transversality and transnational of actions. Thus the climate-change phenomenon affecting the island state of Tuvalu and possible solutions for the resulting climatic and political issues go through State action as well as through discussions in international organizations. The principle of citizenship linked to the States is fragmented, since internally, the Tuvalu's State, by losing its territory with rising sea level, cannot guarantee its citizens the right to life and their permanence in its territory. Although politically and economically insignificant, the country claimed the aid of many international actors, specially the great powers to ratify protocols, treaties and agreements aiming at reducing gas emission of polluting gases. However, contrary to Tuvalu's aspirations, it creates a conceptual discourse on the origin of environmental refugees or stateless persons and their possible international legal framework in the body, but did not discuss possible mitigation and adaptation solutions that mitigate the specific problem.
Olausson, Andreas, i Stefanus Louca. "Reviewing Code Review : Defining and developing High-level ConceptualCode Review at a financial technology company". Thesis, KTH, Lärande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273982.
Pełny tekst źródłaKodgranskning är en vanligt förekommande aktivitet hos mjukvaruföretag där källkoden,eller delar av den, genomgår en granskning för att upptäcka möjliga fel innan kodensläpps till produktion. En variation av kodgranskning som är vanlig idag kallas modernkodgranskning och är en mindre formell kodgranskning där utvecklarna själva är medoch kontinuerligt reviderar sina kollegors kod.Ett finansiellt teknikbolag i Stockholm tillämpar modern kodgranskning. Företagethar uttryckt ett behov av att implementera ett verktyg som kan underlättakodgranskningsprocessen. Ett förslag från företaget var att implementera HCCR, enidé om ett verktyg där kodändringar automatiskt sorteras till olika, så kallade, commits1med ett specifikt meddelande.För att implementera verktyget behöver HCCR definieras och konkretiseras. Som ettförsta steg i projektet behövde vi undersöka utvecklarnas önskvärda information av huren commit bör utformas. Projektet behandlar följande forskningsfrågor: Vilken information är önskvärd och behövs av utvecklarna på ett medelstort företag,för att hjälpa dem att göra kodgranskningar i en pull-based miljö?– Vad ska informationen bestå av?– Hur skall informationen presenteras?För att svara på frågorna gjordes intervjuer med mjukvaruutvecklarna på företagettillsammans med observationer där utvecklarna fick prova på en första iteration avHCCR. Den första iterationen togs fram genom att använda företagets riktlinjer gällandehur utvecklare bidrar med kodändringar tillsammans med åsikter från handledaren påföretaget om hur verktyget kan fungera. Intervjuerna spelades in och transkriberades1När det kommer till ord och uttryck inom Git, (exempelvis commits, pull-request, push, pull) finnsdet ingen standardiserad översättning till svenska. Därför kommer dessa ord skrivas på engelska isammanfattningen.ivvarpå en tematisk analys genomfördes. Från analysen framträdde 13 koncept kringkodgranskning vilka delades in i fem kategorier. Utvecklarna önskade att varje commitskulle vara atomisk, kompilerbar samt testbar för att underlätta felsökning av buggar.Utvecklarna uttryckte också ett behov av att få tydlig information om både PR ochcommit-meddelanden. I intervjuerna framkom det att meddelandena borde bestå av:vad som har ändrats och varför det har ändrats. Det observerades även skillnader ikodgranskningsprocessen då olika utvecklare använder olika strategier när de granskarkod.Baserat på den information som framträdde från intervjuerna och observationernatillsammans med tidigare forskning utarbetades en andra iteration av HCCR. Rapportenavslutas med att diskutera möjliga implementationer av verktyget.
Baú, João Paulo Trevizan. "Interação de biomoléculas com goethita e sais da água do mar : um estudo de química prebiótica". Universidade Estadual de Londrina. Centro de Ciências Exatas. Programa de Pós-Graduação em Química, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000189425.
Pełny tekst źródłaInteraction of biomolecules with seawater salts and minerals were studied. From these analyzes, it was found that the solids obtained from the lyophilization of adenine when these solutions were agitated with distilled water at acidic or basic medium as well at different artificial seawaters were observed structural changes. These changes were due to protonation at acidic medium and interaction with cation of the seawaters. The FT-IR and Raman spectra show the appearance of bands of the hydrochloride adenine due to the interaction with the salts of the seawater. In the presence of the salts of the seawater, was observed shifts of the bands, indicating an interaction with the adenine. Experiments carried out with amino acids (Gly, Ala) and goethite showed that the glycine can crystallize with different phases depending on the method used (A, B and C). It was not observed the formation of peptides by FT-IR spectra. It is important to note that the mineral did not suffered modification with treatments. However, there was a loss of intensity in the EPR signal with the methods, indicating a possible organization of the Fe (III) and making a fully antiferromagnetic material.
Coutinho, Murilo Ameno. "Síntese de ferrihidrita na presença de água do mar artificial e tiocianato de amônio : um experimento de química prebiótica". Universidade Estadual de Londrina. Centro de Ciências Exatas. Programa de Pós-Graduação em Química, 2018. http://www.bibliotecadigital.uel.br/document/?code=vtls000219592.
Pełny tekst źródłaPrebiotic chemistry studies the reactions that could have contributed to the origin of life. The Fe is the fourth most abundant element in the Earth's crust, so most likely it must have played an important role in the origin of life. The present work has as main objective the synthesis of ferrihydrite in conditions of prebiotic chemistry and later characterization of the oxides obtained. The standard synthesis of ferrihydrite -6-lines and variations of this was carried out using artificial seawater 4.0 Ga and NH4SCN 1:1 Fe3+. We emphasize that the artificial seawater 4.0 Ga has its composition of cations and anions different from the today's seawater. Today's seawater has high concentration of Na+ and Cl-, and the artificial seawater 4.0 Ga has a high concentration of Mg2+ and SO42-. In addition to the ferrihydrite -6-Lines, a mixture of iron oxides (goethite, magnetite and hematite) were obtained and characterized. The artificial seawater decreased the crystallinity of the ferrihydrite and consequently the surface area of the material was altered. The SO42- was adsorbed onto the materials, decreasing the pHPZC of them. The way the NH4SCN is added to the reactional medium changes the final product of iron oxides obtained. The infrared spectra of the samples showed bands in 624 cm-1 from the Fe-O bond of ferrihydrite and oxide mixture, with bands in 793cm-1 and 894cm-1(Fe-O) of goethite, 588cm-1 (Fe-O) of magnetite and 430cm-1 (Fe-O) of hematite. The samples synthesized with NH4SCN presented bands in 2976 cm-1 (N-H) and in 2041 cm-1, demonstrating the effectiveness of the interaction of ammonium thiocyanate in the iron oxides. The highest mass losses in thermal decomposition correspond to the dehydration process, reaching up to 14.9% of the total sample mass. In the range of 700-900 °C occurred the phase transition to hematite in all samples. From the PCA calculations of X-ray Fluorescence it was possible to qualify the percentages of each iron oxide in the samples that presented mixture of iron oxides.
Ahumada, Zuaza Luis. "El Teatro Infantil y Juvenil de Carmen Conde". Doctoral thesis, Universidad de Murcia, 2011. http://hdl.handle.net/10803/94519.
Pełny tekst źródłaEn el presente trabajo de investigación se aborda el estado de la cuestión del teatro infantil y juvenil de Carmen Conde. a su vez se realiza un profundo estudio histórico-biográfico de lo que supuso dicho género literario en la producción literaria de la autora y la España del siglo XX. Se abordan otros aspectos como: Análisis de sus textos dramáticos infantiles, aspectos pedagógicos de los mismos, índice temático, etc. Acompaña a dicho estudio una amplia y rica bibliografía sobre la autora y su dramaturgia infantil.
Dang, Xiaoyu. "An Optimum Detector for Space-Time Trellis Coded Differential MSK". International Foundation for Telemetering, 2007. http://hdl.handle.net/10150/604515.
Pełny tekst źródłaThe accuracy of channel estimation plays a crucial role in the demodulation of data symbols sent across an unknown wireless medium. In this work a new analytical expression for the channel estimation error of a multiple input multiple output (MIMO) system is obtained when the wireless medium is continuously changing in the temporal domain. Numerical examples are provided to illustrate our findings. Space-time (ST) coding using Continuous Phase Modulation (CPM) has spectral advantages relative to linear modulations. In spite of the spectral benefits, Space-Time Trellis Codes (STTC) using the CPM implementation of Minimum Shift Keying (MSK) scheme has inherent inphase and quadrature interference, when the received complex baseband signal is the input into the matchfilter to remove the shaped sinusoid pulses. In this paper a novel optimum transmitting and detecting structure for STTC-MSK is proposed. Treating the Alamouti scheme as an outer code, each STTC MSK waveform frame is immediately followed by the orthogonal conjugate waveform frame at the transmit side. At the receiver first orthogonal wave forming is applied, then a new time-variant yet simple trellis structure of the STTC-MSK signals is developed. This STTC-MSK detector is absolutely guaranteed to be I/Q interference-free and still keeps a smaller computation load compared with STTC-QPSK. Simulations are made over quasi-static AWGN fading channel. It is shown that our detector for ST-MSK has solved the I/Q interference problem and has around 2.8 dB gain compared with the Alamouti Scheme and 3.8 dB gain for bit error rate at 5 X 10^(-3) in a 2 by 1 Multiple Input Single Output system.
Chami, Malik. "Développement d'un code de transfert radiatif pour le système océan-atmosphère : application au détroit du Pas-de-Calais". Littoral, 1997. http://www.theses.fr/1997DUNK0012.
Pełny tekst źródłaThe observation of the sea surface from space proovides informations about the water content in suspended matter. Numerous sensors are launched in order to assess the pigment concentration in the open ocean (case I) as well as in the coastal waters (case II). Therefore, we need to understand the mechanisms which affect the solar beam in the ocean-atmosphere system. We thus developed a radiative transfer code for both atmosphere and coastal layer. The validation of this code was carried out first through an inter-comparison between existing models and second through truth measurements. The observation of the ocean is made throughout the atmosphere wich disturbs the pathways of the solar beam. We thus need to correct the signal for atmospheric effects. Among the components of the atmosphere, aerosols are the most difficult to remove because of their strong variability in time and space ; it is then useful to derive them locally. Atmospheric optical measurements were carried out in the Straits of Dover in 1994 ans 1995 in order to describe the aerosols. The analysis of the polarized radiation enabled to identify a mode of small particles, correctly represented by Shettle and Fenn’s size distribution. The atmospheric contribution to the signal has been removed using Shettleand Fenn’s models on POLDER airborne scenes to get the water leaving radiance. Marine optical measurements were also collected in the water column in summer and autumn. Summer experiments were favorable to remote sense chlorophyll pigments whereas autumn ones concerned mineral particles. The analysis of marine and satellite data showed that a map of suspended matter concentration was possible. Also the theoretical sensitivity studies conducted in this work revealed that the sediment signature could possibly be extracted from the polarized radiance
Teinturier, Samuel. "Dynamique et stabilité de tourbillons océaniques en interaction avec la cote ou la topographie". Palaiseau, Ecole polytechnique, 2008. https://pastel.archives-ouvertes.fr/tel-00430962.
Pełny tekst źródłaRabillard, Aurélien. "Interactions magmas-détachements : Du terrain (Mer Egée, Grèce) à l'expérimentation". Thesis, Orléans, 2017. http://www.theses.fr/2017ORLE2061/document.
Pełny tekst źródłaMagma intrusions within the lithosphere are often considered as thermomechanical instabilities capable to locally and transiently stimulate strain localization. With the aim of testing this model and determining possible mechanisms that govern the initiation of localized deformation at the contact and within magmatic bodies, this thesis combine a fieldwork with an experimental approach. The Cyclades (Aegean Sea, Greece) form a highly extended continental domain in which five metamorphic core complexes (MCCs) were intruded by magmatic complexes, themselves capped by detachment systems. All collected structural and kinematic data, combined with previous investigations, converge toward a regional scheme in which magmatic bodies dynamically impacted the late evolution of the Cycladic MCCs. Granitoids were emplaced in relatively short time period (15-9 Ma) while metamorphic domes were largely exhumed after more than 10 Myrs of extension. None of those intrusions thereby proves to be a real candidate for the genesis of MCCs. However, continuums of deformation recorded within granitoids (magmatic to ductile/brittle states) as well as geometrical relationships with detachments suggest a pivotal role of magmatic complexes in redistribution and localization processes of the deformation, with in particular the sequential development of detachments. Precursors of strain localization within partially cristallized magmas have been concurrently deciphered by an experimental study. The investigation of the structural behavior of magmas, chemically and texturally similar to natural systems, corroborates that strain localization is efficiently activated along interfaces with contrasting rheology such as in the vicinity of synplutonic dikes. It has been also shown that the initial presence of textural inhomogeneities (e.g. like clusters) in medium-crystallized magmas can drastically influence the degree of strain localization during subsequent cooling stages
Cattelan, Vittorio <1989>. "Il monastero di Gabriel Mor nella regione di Tur Abdin come caso simbolo di intolleranza religiosa in Turchia". Master's Degree Thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/5803.
Pełny tekst źródłaCaval, Vincent. "Utilisation des propriétés d'assemblage de virus hétérologues pour l'étude du cycle viral du virus de l'hépatite C". Thesis, Tours, 2012. http://www.theses.fr/2012TOUR3319/document.
Pełny tekst źródłaThe advent of infectious molecular clones of Hepatitis C virus (HCV) has unlocked the understanding of HCV life cycle. However, packaging of the genomic RNA, which is crucial to generate infectious viral particles, remains poorly understood. To study packaging in vivo, we developed a novel heterologous system to evaluate the interactions of HCV Core capside with viral RNA. This system allowed us to pinpoint Core domains involved in RNA binding, and package and transfer HCV RNA into a lentiviral vector. Aside from this Core dependent recruitment, we engineered retoviral vectors to trans-package MS2-tagged RNAs using MS2 Coat protein interaction. This system allowed us to efficiently recruit MS2-tagged replicons into naive cells and offers the opportunity to visualize HCV RNAs in Huh7.5 cells
Dufraisse-Charmillon, Chloé. "La réécriture du droit social maritime au sein du code des transports". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM1044.
Pełny tekst źródłaThe transport code now hosts social maritime law rules. The government was empowered to proceed, in 2010, to a recodification on the basis of established law of its disparate provisions, including those contained in both the labour code and the maritime labour code. Although this operation was to take place without changing the rule of law, a certain instability became obvious. The subject matter's structure was dramatically altered. It reveals an ambivalence : the transport code is exhibited as an instrument of social progress, yet it may also become a deregulation tool. To compound matters, its regulatory aspect remains very incomplete. The articulation of the new code with the labour code is equally perplexing, most notably with regard to the relationship between common law and special law. This rewriting has, in addition, undergone the influence of international law. The integration of the International labour organization's maritime labour convention made it possible to reaffirm the foundational guidelines of this topic as well as the specificity of laws applicable to seafarers. Moreover, these normative dynamics have paradoxical effects. In fact, international law contributes alternately to the destruction and reconstruction of national rights. Thus, the rewriting of the topic within the transport code could be the harbinger of an alignment of maritime social legal foundations with international standards, which, when compared with french law, are not necessarily more protective. This legal evolution reflects is due to a ruthless international competition that enables social dumping conditions
Mehl, Caroline. "La transition ductile-cassant : évolution structurale et rôle des fluides, exemple des Cyclades, Mer Egée". Paris 6, 2006. http://www.theses.fr/2006PA066064.
Pełny tekst źródłaKadi, Nour. "Optimized broadcasting in wireless ad-hoc networks using network coding". Paris 11, 2010. http://www.theses.fr/2010PA112380.
Pełny tekst źródłaNetwork coding is a novel technique which attracts the research interest since its emergence in 2000. It was shown that network coding, combined with wireless broadcasting, can potentially improve the performance in term of throughput, energy efficiency and bandwidth utilization. Our study begins with integrating network coding with multipoint relay (MPR) technique. MPR is an efficient broadcast mechanism which has been used in many wireless protocols. We show how combining the two techniques together can reduce the number of transmitted packets and increase the throughput. We further reduce the complexity by proposing an opportunistic coding scheme which performs coding operations on the binary field. Instead of linearly combining packets, we employ arithmetic summing packets in modulo 2, which simply corresponds to XOR the corresponding bits in each packet. These operations are computationally cheap. Using neighbors state information, a node in our scheme chooses packets to encode and transmit at each transmission trying to deliver a maximum number of packets. Therefore, an exchange of the reception information between the neighbors is required. To reduce the overhead of the required feedback, we propose a new coding scheme. It uses LT-code (a type of fountain code) to eliminate the need of a perfect feedback among neighbors. This scheme performs encoding and decoding with a logarithmic complexity. We optimize LT-code to speed up the decoding process. The optimization is achieved by proposing a new degree distribution to be used during the encoding process. This distribution allows intermediate nodes to decode more symbols even when few encoded packets are received
El, Khoury Victoria Dufer Jean. "Etude de modifications épigénétiques corrélées à l'expression du gène MDR1 et à la texture nucléaire dans des cellules de carcinome pulmonaire H69 sensibles et résistantes à la chimiothérapie". S.n. : S.l, 2006. http://scdurca.univ-reims.fr/exl-doc/GED00000322.pdf.
Pełny tekst źródłaZackrisson, Elin, i Moa Egertz. "”de tycker ja e mer en kulturell grej än en språklig sak” : En kvalitativ studie kring olika former av tvåspråkighet". Thesis, Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33944.
Pełny tekst źródłaCosta, Joana Ferreira Fournier. "Parque Botânico do Monteiro-Mor, Lisboa: contributo para o seu plano de gestão e de manutenção". Master's thesis, ISA/UL, 2015. http://hdl.handle.net/10400.5/11171.
Pełny tekst źródłaThe Botanical Park of Monteiro-Mor is the case study discussed throughout this dissertation. Situated in the historic district of Lumiar, in the northern boundary of the city of Lisbon, was built in the eighteenth century by the 3rd marquis of Angeja and covers an area of 11 ha. This work aims to contribute to the preparation of the management and maintenance plan that will preserve, restore and conserve the historical, cultural and natural heritage of this place. The study of the park consists primarily on an extensive literature review that results in the historical framework of the park over the eighteenth, nineteenth and twentieth centuries. It is essential to the understanding of this place, its origins and its evolution over the centuries that went through to the present. Then is performed a review of all its components, from the characterization of the biophysical factors that are intrinsic to him, lifting each of the structures that compose it, analyzing their needs and capabilities in order to perform an intervention proposal that aims at the development and promotion of the park, with the main objective and concern to safeguard the integrity and authenticity of this historic garden and cultural landscape
El, Khoury Victoria. "Etude de modifications épigénétiques corrélées à l'expression du gène MDR1 et à la texture nucléaire dans des cellules de carcinome pulmonaire H69 sensibles et résistantes à la chimiothérapie". Reims, 2006. http://www.theses.fr/2006REIMP203.
Pełny tekst źródła@Multidrug resistance often results from the expression of P-gp, an efflux pump encoded by the MDR1 gene. However molecular mechanisms that regulate MDR1 gene remain poorly understood. This study examined the consequences of epigenetic modifications on nuclear phenotype and MDR1 gene expression in lung carcinoma cell lines sensitive (H69WT) and resistant to chemotherapy (H69VP). H69VP resistant cells overexpressing MDR1 gene display nuclear texture alterations, as compared with H69WT sensitive cells, underlining a more uniform distribution of chromatin. Treatment with trichostatin A (TSA), a histone deacetylase inhibitor, induces a progressive and transient chromatin decondensation in sensitive and resistant cells respectively. These modifications seem to reflect variations of H3 acetylation levels on the MDR1 promoter. TSA up-regulates MDR1 gene expression in H69WT cells and down-regulates its expression in H69VP cells through a transcription mechanism without affecting MDR1 mRNA stability and independently of MDR1 promoter methylation and PCAF recruitment to the MDR1 inverted CCAAT box. Translation inhibition reduces these modulations without suppressing them, suggesting that TSA modifies the expression and DNA binding of transcription factors implicated in the regulation of MDR1 gene. These findings indicate that HDAC inhibitors may represent potential anticancer drugs in multidrug resistant tumors
Gerardin, Delphine. "Développement de méthodes et d’outils numériques pour l’étude de la sûreté du réacteur à sels fondus MSFR". Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAI068/document.
Pełny tekst źródłaThis PhD thesis focuses on the study of the Molten Salt Fast Reactor (MSFR) safety. It includes risk analysis methods and deterministic computations for the safety and the design of the reactor. This work was performed in the frame of the SAMOFAR European project.The MSFR is an is-breeder reactor with a fast neutron spectrum. In its reference configuration, defined at the beginning of the SAMOFAR project, it works with the thorium fuel cycle. The MSFR was selected by the Generation IV international forum for its promising features. As any fourth-generation reactor, it must fulfill several objectives including an improved safety. Thus, safety studies should be performed from the early design phases to achieve a safety that is built-in the design rather than added-on. Because of the unique characteristics of the MSFR, including a liquid circulating fuel, and its preliminary design phase, the safety assessment of the reactor should rely on adapted and technological neutral methodologies. In this PhD, such a methodology was developed and a first application to the MSFR was carried on. It allowed to identify the initiating events of the reactor and to elaborate a restricted list of events to be studied in the next steps of the safety analysis.Furthermore, a new code system was developed for the safety studies. It is based on neutronic diffusion and takes into account the movement of the delayed neutrons precursors and the production of the residual heat in the fuel. It was used to simulate the transients associated to some of the identified initiating events with the objective to evaluate their consequences and the need for adequate protection systems. This work confirmed the importance of a device that is specific to the MSFR: the emergency draining system (EDS). It allows to drain the fuel in case of accident in the core. Parametric studies were then carried on for the sizing of the EDS with the objective to ensure the evacuation of the residual heat and the sub-criticality of the system under any circumstances.Finally, a first version of the safety architecture was proposed with the identification of the protection systems and the definition of the confinement barriers. Thanks to the safety studies, feedbacks on the initial design were made to enhance the safety the reactor. They include the addition of new components, the modification of some systems and they highlight the lack of knowledge on some phenomena or procedure. In that respect, the safety analysis fulfil its main objective: to influence the design of the reactor since its conception in order to improve its safety
FERNANDES-VANDERLEI, LAZARO. "Etude geochimique des sediments marins actuels d'une cote a plateau continental etroit : exemple des alpes maritimes". Nice, 1987. http://www.theses.fr/1987NICE4120.
Pełny tekst źródłaTirler, Günter, i Josef Leydold. "Automatic Nonuniform Random Variate Generation in R". Department of Statistics and Mathematics, Abt. f. Angewandte Statistik u. Datenverarbeitung, WU Vienna University of Economics and Business, 2003. http://epub.wu.ac.at/382/1/document.pdf.
Pełny tekst źródłaSeries: Preprint Series / Department of Applied Statistics and Data Processing
Robert, Samuel. "La vue sur mer et l'urbanisation du littoral : approche géographique et cartographique sur la Cote d'Azur et la Riviera du Ponant". Nice, 2009. https://tel.archives-ouvertes.fr/tel-00442279.
Pełny tekst źródłaThis thesis deals with the interactions between urbanization and visual landscape, in order to understand and anticipate territorial dynamics in coastal areas. For many decades, European and Mediterranean coasts have been being subjected to urban sprawl, resulting from tourism and residential economy. The issue of visual landscape amenities as a factor of urban sprawl as well as a potential tool of regulation therefore constitutes a crucial perspective. In this context, studying sea views, a major component of coastal landscapes, seems to be a key element. Consequently, it comes to formulate the hypothesis of the sea visibility influence on urban sprawl in coastal areas and simultaneously, of the relevance of geographical knowledge of sea visibility in coastal management. In order to demonstrate the impact of sea visibility on coastal urbanized areas, this study proposes in a first time, a methodology to map coastal areas offering sea views and secondly, a spatial analysis of the interactions between sea visibility and land cover. The study focuses on two Mediterranean coastal zones, which territorial development is strongly related to landscape characteristics : the French Riviera, in Southern France, and the West Ligurian Riviera, in North-West Italy. The analysis handles two different scales and various geographical levels, using geographical information tools and methods (GIS is at the heart of the process). Once this approach validated, it is relevant to support the idea of sea visibility mapping as a tool in land planning. An experiment has been realized in collaboration with one coastal municipality of the Alpes-Maritimes province (France)
Kashtan, Nadav. "La cote septentrionale de la palestine de 332 a. C. A 70 p. C. : les villes, le littoral et la mer". Université Marc Bloch (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR20022.
Pełny tekst źródłaDuring the hellenistic and roman periods, the northern coast of palestine was a well-defined entity that we propose to call "the phoenico-palestinian coast". This appellation brigs out the essential feature of the region, namely the fact that its history and cultural identity were deeply imprinted with the phoenician heritage. From the archaeological and literary sources, on which this study mostly rests, one can derive an idea of the diverse relations between the three elements successively examined: the sites, the littoral itself and the sea. The coastal sites include several cities amongst which akko-ptolemais, a real maritime metropolis, dora, their smaller dependencies, as well as the carmel range. The littoral is considered in the light of its geographical position, its political history and its economy that combined continental and maritime activities. The mediterranean exerted a decisive influence by providing the region with an opening on to the outside world; its impact on the mentality of the population contributes to the development of a religious and cultural syncretism, typical of the phoenico-palestinian coast
GUERRIERO, Paola. "Studio del potenziale terapeutico del miR-199a-3p come agente di profilassi e anti-tumorale in modelli pre-clinici di epatocarcinoma". Doctoral thesis, Università degli studi di Ferrara, 2019. http://hdl.handle.net/11392/2487889.
Pełny tekst źródłaHepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Poor prognosis is related to delayed diagnosis and mostly ineffective therapeutic strategies. In this study we analysed the anti-tumoral potential of miR-199a-3p mimic molecules, since miR-199a-3p is downregulated virtually in all HCCs if compared with normal liver tissues. To test miR-199a-3p potential effects, we exploited the transgenic mouse model TG221, which is prone to HCC development, using two different experimental conditions: (1) anti-tumoral effect was tested against DEN-induced advanced tumors; (2) HCC prevention was studied in mice exposed to the hepatotoxin CCl4. Moreover, by CCl4 treatment, the TG221 mouse could recapitulate the different phases of chronic liver disease progression to HCC (fibrosis -> cirrhosis -> dysplastic nodules -> HCC), essential condition to perform our analysis about the second point of this study. We demonstrated that miR-199a-3p could exert an anti-tumoral activity against advanced HCC, by inhibiting tumor growth in a way comparable to that obtained with Sorafenib in TG221-DEN model. In TG221 CCl4-treated mice, we showed a reduction in liver tumor number and dimension for mice that received miR-199a-3p mimic as preventive care and, additionally, none of these nodules had malignant features. In both the experimental protocols, miR-199a-3p increase led to the downregulation of its direct targets MTOR and PAK4, proteins involved in several pathways that promote cellular proliferation and survival. These in vivo results were confirmed by in vitro assays. We demonstrated that restoration of miR-199a-3p in HCC cell lines elicited a significative pro-apoptotic effect by reducing MTOR and PAK4 protein levels. In conclusion, our study illustrates miR-199a-3p therapeutic potential in vivo, both as an anti-tumoral therapy against advanced HCC and as a prophylaxis agent in pre-cancerous conditions, suggesting that miR-199a-3p mimics might be exploited as therapeutic molecules in all the different phases of HCC.
Karmann, Silvia Kristin [Verfasser]. "Die Ordonnance de la marine und die französische Versicherungspraxis. : Die Entwicklung des Versicherungsvertragsrechts in Frankreich vom Guidon de la mer bis zum Code de commerce. / Silvia Kristin Karmann". Berlin : Duncker & Humblot, 2021. http://d-nb.info/1238492584/34.
Pełny tekst źródłaEriksson, Malin. "Kundorderstyrd tillverkning – Påverkande faktorer, förutsättningar och problem : En övergripande studie om hur små och medelstora företag flyttar kundorderpunkten och går mot mer kundanpassning". Thesis, Högskolan i Skövde, Institutionen för teknik och samhälle, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-5165.
Pełny tekst źródłaService, Bruce Dale. "What Goes Up Must Come Down: The Relationship between the Housing Market Boom and the Subsequent Economic Downturn: Evidence from the MSA Level". Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1502.
Pełny tekst źródłaCarton, Hélène. "Etudes tectoniques en Méditerranée orientale par analyse de données de sismique réflexion : Mer de Marmara (Bassin de ̧Cinarcik) et Marge du Liban". Paris, Institut de physique du globe, 2005. http://www.theses.fr/2005GLOB0019.
Pełny tekst źródłaHerbert, Vincent. "La circulation maritime dans le detroit de malacca et ses effets sur la cote occidentale de la peninsule malaise". Nantes, 1999. http://www.theses.fr/1999NANT3006.
Pełny tekst źródłaThe strait of malacca is one of the busiest maritime passage in the world, and the western coast of the malay peninsula is connected to the maritime traffic of this region. Thus it provides a possible way to carry out a geographical analysis of a limited area and yet which is full of various landscapes and actors. The study looks upon the straits of malacca as a geosystem which is made up of three prevailing systems. The strait is situated in a regional and international economic background which can explain why and how the maritime traffic has expanded in such a spectacular way. An analysis of the maritime traffic (which includes the transverse movements) identifies the main users of this strait. Lastly, the physical environment is a determining and restricting factor for the choice of the sea routes. A first research line associates the important traffic of the strait with the effects noticed on the activities of the western coast of the malay peninsula : port industries, fishing, aquafarming and tourism. The second line is dedicated to the means used to improve the maritime traffic security. It has led us to create a rating for the risk of maritime pollution. After the comparison between the share of this pollution and those of continental and coastal origins, we have analysed the malaysian government management policy (administrative structures, political choices, diplomatic relationships. . . ) to see if it corresponded to the pollution issues. By analysing the spatial effects of the strait of malacca maritime traffic on the western coast of the malay peninsula, this thesis intends to give a method of geographical analysis wich can be applied to straits as well as to narrow maritime area
Albertsson, Robin, i Joakim Hermansson. "LNG träningsmanual för M/T Bit Viking". Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-31440.
Pełny tekst źródłaThis paper has been produced as a result of an assignment set by Tarbit Shipping which 2011converted one of their product tanker ships from M/T Bit Viking its original heavy fuel oil toLNG (Liquefied Natural Gas). The assignment was to establish a training manual to the shipaccording to IMO´s (International Maritime Organization) IGF code. The manual is written inthree main parts Category A, Category B and Category C. Category A is directed at ratingsand cadets and focuses on gas and safety procedures, Category B is directed at deck officersand focuses on gas, whilst Category C is directed at engine officers and, similar to Category Baims at increasing knowledge levels for engineers. The manual is now located onboard theship and at the company’s office for education of new personnel and for continued educationfor personnel onboard. The manual is a result on an interpretation of IMO´s IGF code(ANNEX11. RESOLUTION MSC.285(86)), in which guidelines are laid out for vesselsfueled by natural gas.
Bouchlaghem, Karim. "Étude expérimentale et numérique de la pollution atmosphérique dans les villes côtières tunisiennes". Brest, 2009. http://www.theses.fr/2009BRES2002.
Pełny tekst źródłaThe development of a morning sea breeze triggers the increase of O3 and SO2 concentrations in Sousse (Tunisia). The wind field changes its direction anticlockwise getting even stronger during the sea breeze. We have shown that during this sea breeze type, the power plant emissions are responsible for harming the air quality in the region. The launching of the afternoon sea breeze favours a late rapid increase of O3 concentration. The recirculation of pollutants coupled with the photochemical production control the variation of O3 concentration in Sousse region. This breeze type generates the front breeze and the retum flow circulation at the summit of the atmospheric boundary layer. The experimental measurements obtained from a fixed and mobile stations supported by satellite imageries (MODIS and SEAWIFS) have served the study of seasonal evolution of the principal atmospheric pollutants over the Tunisian coasts. The obtained results show that the evolution of O3 concentration is due to the late breeze setting. As far as dust is concerned, this study shows that the increase in its concentration bas been observed simultaneously in the four measurement sites (Bizerte, Sousse, Sfax and Tunis). This fact has permitted us to point out the Saharan dust implication. The evolution of the concentration of primary pollutants NO, NO2 and SO2 depends on the movement of the air masses and the photochemical transformation. In order to validate these experimental results, we achieved a numerical study using the FLUENT code, simulating the phenomenon of dispersion of a pollutant in presence of a three dimensional flow. The model results fit with the experimental measurements. We pointed out the 3D behaviour of the pollutants dispersion and their contribution to the increase in their surface concentration
Bronner, Emilie. "Amélioration des performances des radars HF à ondes de surface par étude d' antenne compacte et filtrage adaptatif appliqué à la réduction du fouillis de mer". Paris 6, 2005. https://tel.archives-ouvertes.fr/tel-00078372.
Pełny tekst źródłaBronner, Emilie. "Amélioration des performances des radars HF à ondes de surface par étude d'antenne compacte et filtrage adaptatif appliqué à la réduction du fouillis de mer". Phd thesis, Université Pierre et Marie Curie - Paris VI, 2005. http://tel.archives-ouvertes.fr/tel-00078372.
Pełny tekst źródłaKonstantinidis, Ioannis. "Le cadre institutionnel de la convention des Nations Unies sur le droit de la mer en quête de son avenir". Thesis, Paris 1, 2016. http://www.theses.fr/2016PA01D001.
Pełny tekst źródłaThe result of protracted and arduous negotiations, the United Nations Convention on the Law of the Seasigned in 1982 is undoubtedly one of the most successful multilateral treaties at the international level. The principle of the common heritage of mankind, represented by the seabed, ocean floor and subsoil and their resources beyond the limits of national jurisdiction, is the cornerstone of the Convention and constituted a major innovation in international law. The success of the Convention lies, in particular, in the establishment of an unprecedented institutional framework, which is incarnated by three institutions: the International Seabed Authority, the Commission on the Limits of the Continental Shelf and the International Tribunal for the Law of the Sea. These institutions of diverse legal status are vested with different functions and have been in operation since the entry into force of the Convention in 1994. Twentyone years following its establishment, it is necessary to review this institutional framework as a whole and to assess its implementation in order to better understand the complementary role of the institutions. This study critically examines the genesis, the nature, the functioning and the practice of the institutions throughtheir interaction and their interdependence. Identifying institutional and inter-institutional weaknesses, and the challenges that the institutions face is an indispensable prerequisite for ensuring effective and viablesolutions, the harmonious implementation of the Convention and for giving substance to the principle ofthe common heritage of mankind. In this context, the role of the Tribunal as the guarantor of the integrityof the Convention and the creative power of the international judge merit special attention
Canali, Andrea. "Analisi delle criticità e delle potenzialità di un depuratore a tecnologia MBR tramite modellazione WEST: scenario attuale e upgrade del depuratore, gestito da HERA, a servizio del Comune di Castel Guelfo (BO)". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Znajdź pełny tekst źródłaButaeye, Étienne. "La maîtrise des compétences de l'équipage du navire marchand pour la prévention des dommages : une prérogative de l'armateur". Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0169/document.
Pełny tekst źródłaThe complexity of operating a vessel requires that crew members have in depth knowledge in a wide variety of areas. The International maritime training that has been standardized by the STCW convention is one of the elements that helps to guarantee their ability to make the maritime expedition a success. But it is not enough. The shipowner is the key actor in this area. His personal investment to maintain and develop technical knowledge, to supervise vessel operation and to implement an appropriate human factor strategy, is crucial for controlling the competencies of his crew to prevent potential damages that could result from human errors. It is very interesting to see that maritime law considers this investment in determining the civil liability regime to which shipowners will be subject for the damages caused by negligence of his crew. His involvement in implementing efficient human strategies will allow him to benefit from wide exemptions or limitation of liability. The very protective civil liability regime he enjoys will nevertheless be lifted, at least partially, for his own omissions that contribute to the damage. Maritime law therefore encourages, in a certain way, shipowners to get involved in vessel crewing. The reality is actually more nuanced because the difficulties to lift this specific regime are various. The protections that are granted to a shipowner will then appear to be a demobilizing factor in controlling the human element, which is essential for maritime safety
Pavlíček, Michal. "Přístupy k zajištění jaderné bezpečnosti u reaktorů 3. generace". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229286.
Pełny tekst źródłaČermák, Jiří. "Návrh elektročásti zařízení na máčení a sušení jader pro tvorbu odlitků". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-318169.
Pełny tekst źródłaBirenjith, P. S. "High-rate MSR Codes, Interior-point Regenerating Codes, and Codes with Hierarchical Locality". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4293.
Pełny tekst źródłaVinayak, R. "On Codes for Private Information Retrieval and Ceph Implementation of a High-Rate Regenerating Code". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/3800.
Pełny tekst źródłaVinayak, R. "On Codes for Private Information Retrieval and Ceph Implementation of a High-Rate Regenerating Code". Thesis, 2017. http://etd.iisc.ernet.in/2005/3800.
Pełny tekst źródłaMoorthy, Prakash Narayana. "Codes With Locality For Distributed Data Storage". Thesis, 2015. https://etd.iisc.ac.in/handle/2005/2648.
Pełny tekst źródłaMoorthy, Prakash Narayana. "Codes With Locality For Distributed Data Storage". Thesis, 2015. http://hdl.handle.net/2005/2648.
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