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Artykuły w czasopismach na temat "Morris wate maze behaviour paradigm"
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Ekwutosi Patricia, Chinwuba, Bakare Adewale Ganiyu, Ben-Azu Benneth i Iwalewa Ezekiel Olugbenga. "Evaluation of the Memory Enhancing Activity of Dichloromethane Fraction of the Methanolic Extract of Pycnanthus angolensis Stem Bark on Experimental Models of Memory Impairment". Drug Research 69, nr 10 (29.05.2019): 551–58. http://dx.doi.org/10.1055/a-0875-3631.
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Abstract Pycnanthus angolensis (Welw) Warb., Myristicaceae, is used extensively in ethnomedicine. Numerous health benefits have been ascribed to the use of different parts of P. angolensis including its role in cognitive function and inflammatory conditions. Hence, this study was undertaken to investigate the effect of stem bark of the plant on memory function in mice.The plant material was pulverized into powder and extracted by maceration with 80% methanol at room temperature for 48 h. This was subsequently fractionated using N-hexane, Dichloromethane (DCM) and Ethyl acetate. The Dichloromethane fraction which is the most potent fraction (25, 50 and 100 mg/kg) was evaluated for memory enhancing activity using the Y-maze (YMT), morris water maze (MWM) and the elevated plus maze (EPM) on D-galactose plus scopolamine and ketamine induced amnesia. The antioxidant markers and acetylcholinesterase (AChE) inhibiting effect of DCM were also investigated.The results obtained from the behavioural study indicates that the DCM fraction significantly (p<0.05) increased alternation behaviour of mice in the YMT, decreased the escape latency in the MWM paradigm and decreased the transfer latency in the EPM. Biochemically, DCM increased glutathione, and superoxide dismutase, but decreased malondialdehyde and AChE activity in the brain.The findings therefore suggests that the DCM possesses significant memory enhancing activity, which may be due to enhancement of antioxidant activity and cholinergic transmission. The attenuation of the effect of ketamine by the DCM may possibly result from an increase in NMDA receptor mediated neurotransmission and attenuation of oxidative stress.
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Cooke, Matthew B., Timothy P. O'Leary, Phelan Harris, Richard E. Brown i Jason S. Snyder. "Pathfinder: open source software for analyzing spatial navigation search strategies". F1000Research 8 (28.08.2019): 1521. http://dx.doi.org/10.12688/f1000research.20352.1.
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Spatial navigation is a universal behavior that varies depending on goals, experience and available sensory stimuli. Spatial navigational tasks are routinely used to study learning, memory and goal-directed behavior, in both animals and humans. One popular paradigm for testing spatial memory is the Morris water maze, where subjects learn the location of a hidden platform that offers escape from a pool of water. Researchers typically express learning as a function of the latency to escape, though this reveals little about the underlying navigational strategies. Recently, a number of studies have begun to classify water maze search strategies in order to clarify the precise spatial and mnemonic functions of different brain regions, and to identify which aspects of spatial memory are disrupted in disease models. However, despite their usefulness, strategy analyses have not been widely adopted due to the lack of software to automate analyses. To address this need we developed Pathfinder, an open source application for analyzing spatial navigation behaviors. In a representative dataset, we show that Pathfinder effectively characterizes the development of highly-specific spatial search strategies as male and female mice learn a standard spatial water maze. Pathfinder can read data files from commercially- and freely-available software packages, is optimized for classifying search strategies in water maze paradigms, and can also be used to analyze 2D navigation by other species, and in other tasks, as long as timestamped xy coordinates are available. Pathfinder is simple to use, can automatically determine pool and platform geometry, generates heat maps, analyzes navigation with respect to multiple goal locations, and can be updated to accommodate future developments in spatial behavioral analyses. Given these features, Pathfinder may be a useful tool for studying how navigational strategies are regulated by the environment, depend on specific neural circuits, and are altered by pathology.
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Cooke, Matthew B., Timothy P. O'Leary, Phelan Harris, Ricky Ma, Richard E. Brown i Jason S. Snyder. "Pathfinder: open source software for analyzing spatial navigation search strategies". F1000Research 8 (15.06.2020): 1521. http://dx.doi.org/10.12688/f1000research.20352.2.
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Spatial navigation is a universal behavior that varies depending on goals, experience and available sensory stimuli. Spatial navigational tasks are routinely used to study learning, memory and goal-directed behavior, in both animals and humans. One popular paradigm for testing spatial memory is the Morris water maze, where subjects learn the location of a hidden platform that offers escape from a pool of water. Researchers typically express learning as a function of the latency to escape, though this reveals little about the underlying navigational strategies. Recently, a number of studies have begun to classify water maze search strategies in order to clarify the precise spatial and mnemonic functions of different brain regions, and to identify which aspects of spatial memory are disrupted in disease models. However, despite their usefulness, strategy analyses have not been widely adopted due to the lack of software to automate analyses. To address this need we developed Pathfinder, an open source application for analyzing spatial navigation behaviors. In a representative dataset, we show that Pathfinder effectively characterizes the development of highly-specific spatial search strategies as male and female mice learn a standard spatial water maze. Pathfinder can read data files from commercially- and freely-available software packages, is optimized for classifying search strategies in water maze paradigms, and can also be used to analyze 2D navigation by other species, and in other tasks, as long as timestamped xy coordinates are available. Pathfinder is simple to use, can automatically determine pool and platform geometry, generates heat maps, analyzes navigation with respect to multiple goal locations, and can be updated to accommodate future developments in spatial behavioral analyses. Given these features, Pathfinder may be a useful tool for studying how navigational strategies are regulated by the environment, depend on specific neural circuits, and are altered by pathology.
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Venkataramaiah, Ch, G. Swathi i W. Rajendra. "MORRIS WATER MAZE – A BENCH MARK TEST FOR LEARNING AND MEMORY DISORDERS IN ANIMAL MODELS: A REVIEW". Asian Journal of Pharmaceutical and Clinical Research 11, nr 5 (1.05.2018): 25. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24292.
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The morris water maze (MWM) was developed by morris as a device to investigate spatial learning and memory in laboratory rats. MWM has become one of the most frequently used laboratory tools in behavioral neuroscience. The MWM task has been often used in the validation of rodent models for neurocognitive disorders (e.g., Parkinson, Alzheimer, Epilepsy, and Schizophrenia), and the evaluation of possible neurocognitive treatments. It is also being used to assess the properties of established potential antipsychotics in animal models of Schizophrenia. The MWM task requires rats to find a hidden platform in a large, circular pool of water that is colored opaque with powdered non-fat milk (or) non-toxic tempera paint where they must swim to the hidden platform. Because they are in the opaque water, the animals cannot see the platform and cannot rely on scent to find the escape route. Instead, they must rely on extra-maze cues. The behavior of rat can be evaluated by analyzing the different parameters such as escape latency, swim speed, and path length, and probe trail. The purpose of this review is to briefly describe procedural aspects, interpretational difficulties of data and advantages of MWM. This paradigm has become a benchmark test for learning and memory difficulties in animal models and preclinical research in general.
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Abderrahim, Laaziz, El Mostafi Hicham, Elhessni Aboubaker, Azeroil Fatima, Touil Tarik, Boumlah Soufiane i Mesfioui Abdelhalim. "Sex differences in behavioral, cognitive and voluntary ethanol-intake effects in Dexamethasone-induced depression-like state in Wistar rat". AIMS Neuroscience 9, nr 2 (2022): 228–49. http://dx.doi.org/10.3934/neuroscience.2022012.
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<abstract> <p>The stress response is attached to psychosomatic and psychiatric disorders. Therefore, it is important to comprehend the underlying mechanisms influencing this relationship. Moreover, men and women respond differently to stress–both psychologically and biologically. These differences should be studied to have an enhanced understanding of the gender difference. However, researches shedding light on sex dimorphism implication have historically been insufficient. Based on observations that advocate the inclusion of sex as a biological variable in stress response, the present study was designed to explore sex differences in (i) depressive-like, (ii) anxiety-like behaviors, (iii) cognitive-like performances, and (iv) voluntary ethanol intake (VEI) in Wistar rat submitted to dexamethasone (DEX)-stress simulation. Rats were administered daily with DEX (1.5 mg/kg, s.c., 21 days) or vehicle. Behavior, cognitive, and VEI states of rats were evaluated in the following paradigms: forced swimming test (FST); saccharin preference test (SPT); open field test (OFT); elevated plus-maze test (EPMT); novelty suppressed feeding test (NSFT); spatial learning and memory in Morris water maze test (MWMT); VEI in two-bottle choice paradigm. DEX-treated rats showed a set of depression-like behaviors: increased time of immobility; reduced preference for saccharin consumption; increased anxiety-like behavior; cognitive impairments; and enhanced VEI. Sexual dimorphism was recorded in this study. Females were more impaired in FST, SPT, EPMT, NSFT, and VEI. Results demonstrate that DEX-treatment induced a behavioral alterations related to anxiety-depressive-like state with learning and memory impairments; confirm the facilitatory role of glucocorticoids on VEI and reveal sexual dimorphism in stress response.</p> </abstract>
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Imam, Aminu, Nafeesah Abdulkareem Sulaiman, Aboyeji Lukuman Oyewole, Samson Chengetanai, Victoria Williams, Musa Iyiola Ajibola, Royhaan Olamide Folarin, Asma’u Shehu Muhammad, Sheu-Tijani Toyin Shittu i Moyosore Salihu Ajao. "Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats". Toxics 6, nr 4 (1.12.2018): 71. http://dx.doi.org/10.3390/toxics6040071.
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The execution of agricultural activities on an industrial scale has led to indiscriminate deposition of toxic xenobiotics, including organophosphates, in the biome. This has led to intoxication characterized by deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to a combination of two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP), on neuro-cognitive performance and anxiety-like behaviors in rats. Thirty-two adult male Wistar rats (150–170 g) were randomly divided into four groups, orally exposed to normal saline (NS), DDVP (8.8 mg/kg), CPF (14.9 mg/kg), and DDVP + CPF for 14 consecutive days. On day 10 of exposure, anxiety-like behavior and amygdala-dependent fear learning were assessed using open field and elevated plus maze paradigms, respectively, while spatial working memory was assessed on day 14 in the Morris water maze paradigm, following three training trials on days 11, 12, and 13. On day 15, the rats were euthanized, and their brains excised, with the hippocampus and amygdala removed. Five of these samples were homogenized and centrifuged to analyze nitric oxide (NO) metabolites, total reactive oxygen species (ROS), and acetylcholinesterase (AChE) activity, and the other three were processed for histology (cresyl violet stain) and proliferative markers (Ki67 immunohistochemistry). Marked (p ≤0.05) loss in body weight, AChE depletion, and overproduction of both NO and ROS were observed after repeated exposure to individual and combined doses of CPF and DDVP. Insults from DDVP exposure appeared more severe owing to the observed greater losses in the body weights of exposed rats. There was also a significant (p ≤0.05) effect on the cognitive behaviors recorded from the exposed rats, and these deficits were related to the oxidative damage and neurogenic cell loss in the hippocampus and the amygdala of the exposed rats. Taken together, these results provided an insight that oxidative and neurogenic damage are central to the severity of neuro-cognitive dysfunction and increased anxiety-like behaviors that follow organophosphate poisoning.
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Giménez-Llort, Lydia, Mikel Santana-Santana, Míriam Ratia, Belén Pérez, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia i Maria Victòria Clos. "Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3". Brain Sciences 11, nr 4 (26.03.2021): 426. http://dx.doi.org/10.3390/brainsci11040426.
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A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer’s disease (AD) pathologies. Sundowning behavior is a common neuropsychiatric symptom (NPS) associated with dementia. Sleep fragmentation resulting from disturbances in sleep and circadian rhythms in AD may have important consequences on memory processes and exacerbate the other AD-NPS. The present work studied the effect of training time schedules on 12-month-old male 3xTg-AD mice modeling advanced disease stages. Their performance in two paradigms of the Morris water maze for spatial-reference and visual-perceptual learning and memory were found impaired at midday, after 4 h of non-active phase. In contrast, early-morning trained littermates, slowing down from their active phase, exhibited better performance and used goal-directed strategies and non-search navigation described for normal aging. The novel multitarget anticholinesterasic compound AVCRI104P3 (0.6 µmol·kg−1, 21 days i.p.) exerted stronger cognitive benefits than its in vitro equipotent dose of AChEI huprine X (0.12 μmol·kg−1, 21 days i.p.). Both compounds showed streamlined drug effectiveness, independently of the schedule. Their effects on anxiety-like behaviors were moderate. The results open a question of how time schedules modulate the capacity to respond to task demands and to assess/elucidate new drug effectiveness.
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Rafi, Hira, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq i Muhammad Farhan. "Comparative Effectiveness of Agmatine and Choline Treatment in Rats with Cognitive Impairment Induced by AlCl3 and Forced Swim Stress". Current Clinical Pharmacology 15, nr 3 (15.12.2020): 251–64. http://dx.doi.org/10.2174/1574884714666191016152143.
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Aim: Endogenous agmatine has a significant role in learning and memory processes as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during the learning process in the rat brain. Dietary intake of choline showed correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias. Methods: 36 Albino rats were equally divided into three groups previously: a) control-water, b) Test I - AlCl3 (100 mg/Kg body weight), and c) Test II - Forced swim stress (FSS) for 14 days. On the next day of AlCl3 and FSS last administration, animals were allocated into further three groups and received the following treatments: a. water was given orally to the control group, b. Agmatine (100 mg/Kg Body Weight) group, and c. Choline (100 mg/Kg Body Weight) group for the next 14 days. Behaviors were assessed in Light/Dark Box, Open Field, Novel Object Recognition Test (NOR), T Maze Test, and Morris Water Maze Test. Results: Animals administered with agmatine demonstrated increased time spent in bright areas of light/dark box and square crossed while improved spatial memory in Morris water maze and T maze test and enhanced discrimination of novel object in NOR were observed in learning and memory paradigms along with choline. Conclusion: The present study determines that agmatine at the dose of (100 mg/kg body weight) attenuates memory and cognitive impairment in comparison with choline supplements.
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Andriushchenko, Nika, Kira Nebogina, Yana Zorkina, Olga Abramova, Eugene Zubkov, Aleksandra Ochneva, Valeria Ushakova i in. "Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress". Scientia Pharmaceutica 90, nr 3 (23.08.2022): 50. http://dx.doi.org/10.3390/scipharm90030050.
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The search for potential effective antidepressants with minimal side effects is necessary. Peptides are possible applicants for this role. We investigated the antidepressant effect of neuropeptide Y (NY), alone and in combination with clomipramine, in models of acute and chronic stress induced by ultrasound of variable frequencies. Rats were divided into the following groups: the control group, stress group, and stress groups with intranasal administration of NY (100 μg/kg) or clomipramine (7.5 mg/kg), or their combination. Rat behavior was evaluated using a sucrose preference test and forced swimming test in an acute stress model, and a sucrose preference test, forced swimming test, social interaction test, open field test, and Morris water maze test in a chronic stress model. The results of our experiment demonstrated a protective effect of intranasal NY in a model of acute stress, which was comparable to the antidepressant effect of clomipramine. When the same dose was chronically administered, NY also demonstrated an antidepressant action, although expressed in a lesser degree than clomipramine. The combination of NY and clomipramine was much less effective in the chronic stress paradigm compared to the separated drug administration, but was just as effective in the acute stress paradigm. Until now, there was no convincing evidence for the efficacy of the chronic administration of neuropeptide Y; we demonstrated its effectiveness in the animal model of depressive-like behavior. However, our hypothesis that neuropeptide Y can enhance the effect of a classical antidepressant was not confirmed.
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McKay, Leah, Louis Hunninck i Michael Sheriff. "A Field-Based Adaptation of the Classic Morris Water Maze to Assess Learning and Memory in a Free-Living Animal". Animal Behavior and Cognition 9, nr 4 (1.11.2020): 396–407. http://dx.doi.org/10.26451/abc.09.04.03.2022.
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Free-living animals rely on cognitive functions, such as learning and memory, for numerous aspects of their survival. However, research involving these mechanisms is often limited to the laboratory where animals are far removed from natural influences. Here, we adapted the Morris Water Maze (MWM) for use in the field to test learning and memory of free-living white-footed mice, Peromyscus leucopus. The MWM consists of a pool filled with opaque water and a platform that is hidden beneath the surface of the water. Mice were tasked with finding an escape platform using proximate-cue based spatial learning skills across trials within and between two tests. The two tests occurred 2 hrs apart and each consisted of 5 trials with a maximum search time of 60 s, separated by 15-s breaks. We found mice demonstrated rapid learning within the first 5 trials, as indicated by a faster time and reduced distanced swam to find the platform in trial 5 as compared to trial 1 in Test 1. We also found mice remembered the task, as indicated by equivalent performance (in time and distance) after the two-hour delay period (i.e., performance in Test 2 trial 1 was similar to that in Test 1 trial 5). Lastly, we found that there was no increase in performance as mice completed an additional 5 trials (i.e., no difference in Test 1 trial 5 vs. Test 2 trial 5). By assessing several variables that serve as standard metrics for learning and memory within the MWM, we were able to illustrate the ability of wild mice to successfully navigate within a modified version of an established learning/memory paradigm. This study is important for promoting more accessible forms of cognitive testing in free-living animals and use of such a method could provide insights into how animals cope with environmental stressors in their natural environment such as anthropogenic disturbance, invasive species, and habitat degradation. A better understanding of cognitive behavior in wild animals may help diminish the disparity of knowledge that is often present between laboratory and field research.
Rozprawy doktorskie na temat "Morris wate maze behaviour paradigm"
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Meenakshi, Prabod Kumar. "Optical and behavioural tools to investigate the neural correlates of learning and memory". Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5521.
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Events in our everyday life are encoded as memories that can be consciously recollected and remembered, although our ability to retrieve the specific details associated with these events diminish with time. Such losses present itself as an inability to distinguish between closely related events. Studying this phenomenon requires development of sensitive tools and methods that can measure and follow these changes at neuronal as well as behavioural scales. We have developed the above tools as a part of my thesis towards specifically addressing how multiple memories that share common content are organised in brain preserving their identity.
First, we developed a general method to distinguish neurons that took part in multiple temporally separated events. We modelled the dynamics of Immediate Early Genes (IEG) expression, a marker for neuronal plasticity, as a consecutive, irreversible first order reaction with a limiting substrate. This model along with two-photon in vivo imaging of the retrosplenial cortex in cFOS-GFP transgenic mice allowed us to follow the dynamic cellular changes resulting from contextual fear conditioning (CFC) behaviour and identify the underlying neuronal subsets. This enabled us to establish representation of context in retrosplenial cortex at the cellular scale following memory acquisition and address how a retrieval event interacts with a new context presented close in time (60-min).
Secondly, we developed a sensitive measure to assess spatial memory in Morris wate maze behaviour paradigm. We used the velocity vector field to describe the search pattern of the mice and develop quantitative measures, namely, accuracy, uncertainty, and intensity of search. These measures reflect the degree of impairment in the memory rather than just identifying if there is an impairment. We demonstrate the usefulness of these measures using four different datasets including comparisons between different strains of mice, an analysis of two mouse models of Noonan syndrome (Ptpn11 D61G and Ptpn11 N308D/+), and a study of goal reversal training. Importantly, besides highlighting novel aspects of performance in this widely used spatial task, our measures were able to uncover previously undetected differences, including in an animal model of Noonan syndrome, which we rescued with the mitogen activated protein kinase kinase (MEK) inhibitor SL327. Thus, our results show that our approach breaks down performance in the Morris water maze into sensitive measurable independent components that highlight differences in spatial learning and memory in the MWM that were undetected by conventional measures.
Lastly, we focused on developing a method to obtain fluorescence lifetime from steady state measurements utilizing a conventional custom built two photon imaging system. Fluorescence at optical saturation is a function of absorption cross section and excited state lifetime. We use this to establish a proof of principle application of measuring lifetime through steady state fluorescence.CSIR-09/079(2697)/2016-EMR-I