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Artykuły w czasopismach na temat "Molecules - Toxicological Interest"
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Manini, P., R. Andreoli, A. Mutti, E. Bergamaschi, I. Franchini i W. M. A. Niessen. "Determination of glucuronides of molecules of toxicological interest by liquid chromatography negative-ion mass spectrometry with atmospheric pressure chemical ionization". Chromatographia 47, nr 11-12 (czerwiec 1998): 659–66. http://dx.doi.org/10.1007/bf02467450.
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Amine, Boumelik Mohamed, Ahmed Youcef, Radja Feriel, Moulai Isra Amel, Belhadj Lahcène i Boublenza Abdellatif. "The value of toxicology in determining cause of death. A study of 400 autopsy cases". STUDIES IN HEALTH SCIENCES 4, nr 1 (28.04.2023): 266–83. http://dx.doi.org/10.54022/shsv4n1-028.
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The interest of a forensic autopsy is the search for the cause of death. However, sometimes doubt suspicion persists about association with toxic substances. In this perspective, it’s important to ask whether such toxicological analyses following a forensic autopsy are important in determining the cause of death. On the other hand, ask yourself, which toxins are most frequently encountered. The question then being is to compare the results of toxicological analyses with the conclusions established during the forensic autopsy. We have tried to show that, during the search for the cause of death, toxicological analyses are essential to assess the participation of xenobiotics in the fatal process. Materials and methods: This is a retrospective study, descriptive study on the analysis of toxicological results compared with conclusions from forensic autopsies (N=400), performed on requisition from the judicial authority of the competent territory, in the forensic medicine department (thanatology unit) of the university hospital of Sidi Bel Abbés (Algeria) during the period from January 01,2017 to December 31,2019. The sampling is carried out on different body fluids to determine how the person died. We had at our disposal blood (cardiac and peripheral), urine, gastric contents. Results: we obtained on our sample of 400, 274 males for 126 females with a sex ratio of 2.17. The minimum age was 0 days. The maximum age was 93 years, with a mean of 38 years and a standard deviation of 23 years. The natural form of death represented 41%, the unatural form (suicidal, criminal, accidental) represented 37% and the undetermined form represented 23%. According to the direct causes of death, acute cardiorespiratory distress represents the majority, i.e. 78.5%. Cardiopulmonary diseases represent the majority (28%), followed by death of traumatic origin (23.3%), death of asphyxic origin (12%) and having remained undetermined (19%). Requests for toxicological analysis of autopsies, including the establishment of the cause of death requiring the results of toxicological analysis represent (45%). Of all the results received (N=42), we found that the results that came back positive represent 43%, of which the molecules with neuro-psychotropic effects represent the majority of 50%, then alcohol (20%) and cannabis (10%). Conclusion: In current forensic practice, the performance and analysis of samples for toxicological purposes appears to be an essential step, in order to better understand the circumstances of unatural deaths, and to clarify some situations for which the cause of death does not appear obvious. The evaluation of the nature of the substances most frequently encountered in search for causes of death can be evaluated over time according to the modes of prescription.
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Gangwar, Mayank, R. K. Goel i Gopal Nath. "Mallotus philippinensisMuell. Arg (Euphorbiaceae): Ethnopharmacology and Phytochemistry Review". BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/213973.
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Mallotus philippinensisMuell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities.Mallotus philippinensisspecies are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals thatMallotus philippinensisis a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited aboutMallotus philippinensisand its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.
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Zhang, Yao, Jie Li, Guoyu Ren, Baofu Qin i Haixia Ma. "Synthesis, crystal structure and antifungal activity of a divalent cobalt(II) complex with uniconazole". Acta Crystallographica Section C Structural Chemistry 72, nr 6 (18.05.2016): 485–90. http://dx.doi.org/10.1107/s2053229616007750.
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Azole compounds have attracted commercial interest due to their high bactericidal and plant-growth-regulating activities. Uniconazole [or 1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol] is a highly active 1,2,4-triazole fungicide and plant-growth regulator with low toxicity. The pharmacological and toxicological properties of many drugs are modified by the formation of their metal complexes. Therefore, there is much interest in exploiting the coordination chemistry of triazole pesticides and their potential application in agriculture. However, reports of complexes of uniconazole are rare. A new cobalt(II) complex of uniconazole, namely dichloridotetrakis[1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl-κN4)pent-1-en-3-ol]cobalt(II), [CoCl2(C15H18ClN3O)4], was synthesized and structurally characterized by element analysis, IR spectrometry and X-ray single-crystal diffraction. The crystal structural analysis shows that the CoIIatom is located on the inversion centre and is coordinated by four uniconazole and two chloride ligands, forming a distorted octahedral geometry. The hydroxy groups of an uniconazole ligands of adjacent molecules form hydrogen bonds with the axial chloride ligands, resulting in one-dimensional chains parallel to theaaxis. The complex was analysed for its antifungal activity by the mycelial growth rate method. It was revealed that the antifungal effect of the title complex is more pronounced than the effect of fungicide uniconazole forBotryosphaeria ribis,Wheat gibberellicandGrape anthracnose.
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El Khawaja, Rebecca, Savita Kaliya Perumal Veerapandian, Rim Bitar, Nathalie De Geyter, Rino Morent, Nicolas Heymans, Guy De Weireld i in. "Boosting VOCs elimination by coupling different techniques". Chemical Synthesis 2, nr 2 (2022): 13. http://dx.doi.org/10.20517/cs.2022.10.
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Volatile Organic Compounds (VOCs) are known to be hazardous and harmful to human health and the environment. In mixtures or during repeated exposures, significant toxicity of these compounds in trace amounts has been revealed. In vitro air-liquid interface approaches underlined the interest in evaluating the impact of repeated VOC exposure and the importance of carrying out a toxicological validation of the techniques in addition to the standard chemical analyses. The difficulties in sampling and measuring VOCs in stationary source emissions are due to both the complexity of the mixture present and the wide range of concentrations. The coupling of VOC treatment techniques results in efficient systems with lower operating energy consumption. Three main couplings are outlined in this review, highlighting their advantages and relevance. First, adsorption-catalysis coupling is particularly valuable by using adsorption and catalytic oxidation regeneration initiated, for example, by selective dielectric heating. Then, several key aspects of the plasma catalysis process, such as the choice of catalysts suitable for the non-thermal plasma (NTP) environment, the simultaneous removal of different VOCs, and the in situ regeneration of the catalyst by NTP exposure, are discussed. The adsorption-photocatalysis coupling technology is also one of the effective and promising methods for VOC removal. The VOC molecules strongly adsorbed on the surface of the photocatalyst can be directly oxidized by the photogenerated hole on the photocatalyst (e.g., TiO2).
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Marques, Dayan de Araújo, Fernando Berton Zanchi i Geisa Paulino Caprini Evaristo. "Ethnopharmacological review, phytochemistry and bioactivity of the genus Geissospermum (Apocynaceae)". Research, Society and Development 12, nr 2 (3.02.2023): e18912240047. http://dx.doi.org/10.33448/rsd-v12i2.40047.
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This narrative review aims to update the ethnopharmacology, phytochemistry and biological activities of Geissospermum species described in the literature, in order to contribute to the knowledge of bioactive compounds of therapeutic interest and establish directions for future research with this genus. The term “Geissospermum” was used to perform searches in different databases such as NDLTD (Digital Library Network of Theses and Dissertations), Google Scholar, PubChem, Scifinder, Web of Science, SciELO, PubMed and Science Direct. Google's National Institute of Industrial Property and Patents (INPI) was also consulted. The keywords indole alkaloids, quina-quina, Geissospermum, Geissospermum reticulatum and malaria were used in the search. Publications in Portuguese, French, Spanish and English published between 1950 and 2022 were included. Indole alkaloids are the main secondary metabolites found in this genus, and several molecules have already been isolated, which may be related to the described pharmacological activities. Extracts and isolated compounds showed antitumor, antimalarial, antinociceptive, anti-inflammatory, anticholinesterase, anti-HIV, antimicrobial and antioxidant activity. Plants of the genus Geissospermum are used in Brazil mainly by the Amazonian peoples to treat various pathologies. Biological activities reported for extracts and isolated compounds are consistent with etonopharmacological use against malaria, cancer and other diseases. Future work with Geissospermum species is needed to elucidate the mechanism of action of the isolated alkaloids, as well as their toxicological profile.
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Poulsen-Silva, Erick, Felipe Gordillo-Fuenzalida, Cristian Atala, Adrián A. Moreno i María Carolina Otero. "Bioactive Lichen Secondary Metabolites and Their Presence in Species from Chile". Metabolites 13, nr 7 (28.06.2023): 805. http://dx.doi.org/10.3390/metabo13070805.
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Lichens are symbiotic organisms composed of at least one fungal and one algal species. They are found in different environments around the world, even in the poles and deserts. Some species can withstand extreme abiotic conditions, including radiation and the vacuum of space. Their chemistry is mainly due to the fungal metabolism and the production of several secondary metabolites with biological activity, which have been isolated due to an increasing interest from the pharmaceutical community. However, beyond the experimental data, little is known about their mechanisms of action and the potential pharmaceutical use of these kinds of molecules, especially the ones isolated from lesser-known species and/or lesser-studied countries. The main objective of this review is to analyze the bibliographical data of the biological activity of secondary metabolites from lichens, identifying the possible mechanisms of action and lichen species from Chile. We carried out a bibliographic revision of different scientific articles in order to collect all necessary information on the biological activity of the metabolites of these lichen species. For this, validated databases were used. We found the most recent reports where in vitro and in vivo studies have demonstrated the biological properties of these metabolites. The biological activity, namely anticancer, antioxidant, and anti-inflammatory activity, of 26 secondary metabolites are described, as well as their reported molecular mechanisms. The most notable metabolites found in this review were usnic acid, atranorin, protolichesterinic acid, and lobaric acid. Usnic acid was the most investigated metabolite, in addition to undergoing toxicological and pharmacological studies, where a hepatotoxicity effect was reported due to uncoupling oxidative phosphorylation. Additionally, no major studies have been made to validate the pharmacological application of these metabolites, and few advancements have been made in their artificial growth in bioreactors. Despite the described biological activities, there is little support to consider these metabolites in pharmaceutical formulations or to evaluate them in clinical trials. Nevertheless, it is important to carry out further studies regarding their possible human health effects. These lichen secondary metabolites present a promising research opportunity to find new pharmaceutical molecules due to their bioactive properties.
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Turkez, Hasan, Ozlem Ozdemir Tozlu, Arzu Tatar, Mehmet Enes Arslan, Kenan Cadirci, Lisa Marinelli, Omer Erkan Yapca, Ivana Cacciatore, Antonio Di Stefano i Adil Mardinoglu. "Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives". Journal of Toxicology 2022 (19.11.2022): 1–8. http://dx.doi.org/10.1155/2022/3775194.
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The tripeptide H-Gly-Pro-Glu-OH (GPE) and its analogs began to take much interest from scientists for developing effective novel molecules in the treatment of several disorders including Alzheimer’s disease, Parkinson’s disease, and stroke. The peptidomimetics of GPEs exerted significant biological properties involving anti-inflammatory, antiapoptotic, and anticancer properties. The assessments of their hematological toxicity potentials are critically required for their possible usage in further preclinical and clinical trials against a wide range of pathological conditions. However, there is so limited information on the safety profiling of GPE and its analogs on human blood tissue from cytotoxic, oxidative, and genotoxic perspectives. And, their embryotoxicity potentials were not investigated yet. Therefore, in this study, measurements of mitochondrial viability (using MTT assay) and lactate dehydrogenase (LDH) release as well as total antioxidant capacity (TAC) assays were performed on cultured human whole blood cells after treatment with GPE and its three novel peptidomimetics for 72 h. Sister chromatid exchange (SCE), micronucleus (MN), and 8-oxo-2-deoxyguanosine (8-OH-dG) assays were performed for determining the genotoxic damage potentials. In addition, the nuclear division index (NDI) was figured out for revealing their cytostatic potentials. Embryotoxicity assessments were performed on cultured human pluripotent NT2 embryonal carcinoma cells by MTT and LDH assays. The present results from cytotoxicity, oxidative, genotoxicity, and embryotoxicity testing clearly propounded that GPEs had good biosafety profiles and were trouble-free from the toxicological point of view. Noncytotoxic, antioxidative, nongenotoxic, noncytostatic, and nonembryotoxic features of GPE analogs are worthwhile exploring further and may exert high potentials for improving the development of novel disease-modifying agents.
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Semmrich, Monika, Jean-Baptiste Marchand, Laetitia Fend, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Eric Quéméneur i Björn Frendeus. "594 BT-001, an oncolytic vaccinia virus armed with a Treg-depleting human recombinant anti-CTLA4 antibody and GM-CSF to target the tumor microenvironment". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (listopad 2020): A629. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0594.
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BackgroundCheckpoint inhibitor antibodies have improved survival in a variety of cancers, however, a great unmet need remains since only a small fraction of patients responds. Reasons for lack of efficacy are believed to include lack of tumor infiltrating immune cells, a notion supported by improved efficacy observed following combined checkpoint blockade with tumor oncolytic virotherapy which promotes intratumoral T cell infiltration. Oncolytic vaccinia viruses (oVV) also allow genetic encoding of transgenes. This is of special interest for therapeutic proteins exhibiting toxicological limitation or pharmacokinetic issues. Here, BioInvent and Transgene present a potentially safe and more efficacious strategy to combine checkpoint inhibition in the context of oncolytic virotherapy.MethodsUsing the F.I.R.S.T™ discovery platform we have isolated a human recombinant Treg-depleting antibody that has been vectorized alongside GM-CSF into the Invir.IO® oVV. This product named BT-001 consists of a Copenhagen double deleted vaccinia virus encoding the human CTLA4-specific antibody 4-E03 IgG1, which shows improved Treg-depletion compared with ipilimumab in a human PBMC-based NOG/SCID-transfer model. BT-001 also encodes GM-CSF, the cytokine expressed in clinically approved products. A surrogate murine mAb was vectorized into the same oVV (mBT-1) allowing for functional and mechanistic in vivo studies.ResultsOur studies demonstrate that 4-E03 and GM-CSF were expressed as functional molecules after infection by BT-001 of human tumor cell lines in vitro. Moreover, following intratumoral administration in immune competent and immune deficient mice transplanted with mouse or human tumors, transgene expression was sustained at levels associated with receptor saturation for days to weeks. In contrast, and supporting the tumor-selective nature of oVV, blood concentrations of anti-CTLA4 mAb were lower compared to those observed following i.v. administration of therapeutic doses of mAb. The in vivo anti-tumor activity of mBT-1 was assessed in multiple syngeneic mouse tumor models including CT26, EMT6, A20 and C38. Murine surrogate mBT-1 conferred cures in the majority of challenged mice irrespective of tumor origin. The excellent anti-tumoral profile depends on anti-CTLA4 expression and could be boosted by co-administration of anti-PD-1 mAb. Intratumoral treatment with mBT-1 also induces abscopal anti-tumor responses and protects against tumor rechallenge demonstrating a long-lasting systemic anti-tumor activity.ConclusionsA clinical batch of BT-001 has been produced and toxicological evaluation is ongoing. Transgene and BioInvent have applied for a clinical trial targeting injectable superficial tumors. Here, the tumor-localized delivery of anti-CTLA4 may allow a better tolerated and more effective combination therapy with antibodies targeting the PD-1/PDL1 axis.
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Bertelà, Federica, Martina Marsotto, Cecilia Meneghini, Luca Burratti, Valentin-Adrian Maraloiu, Giovanna Iucci, Iole Venditti i in. "Biocompatible Silver Nanoparticles: Study of the Chemical and Molecular Structure, and the Ability to Interact with Cadmium and Arsenic in Water and Biological Properties". Nanomaterials 11, nr 10 (28.09.2021): 2540. http://dx.doi.org/10.3390/nano11102540.
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In the field of research for designing and preparing innovative nanostructured systems, these systems are able to reveal the presence of heavy metals in water samples, and can efficiently and selectively interact with them, allowing for future applications in the field of water remediation. We investigated the electronic and molecular structure, as well as the morphology, of silver nanoparticles stabilized by mixed biocompatible ligands (the amino acid L-cysteine and the organic molecule citrate) in the presence of cadmium and arsenic ions. The molecular, electronic, and local structure at the ligands/silver nanoparticles interface was probed by the complementary synchrotron radiation-induced techniques (SR-XPS, NEXAFS and XAS). The optical absorption (in the UV-Vis range) of the nanosystem was investigated in the presence of Cd(II) and As(III) and the observed behavior suggested a selective interaction with cadmium. In addition, the toxicological profile of the innovative nanosystem was assessed in vitro using a human epithelial cell line HEK293T. We analyzed the viability of the cells treated with silver nanoparticles, as well as the activation of antioxidant response.
Części książek na temat "Molecules - Toxicological Interest"
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Raghavender Suresh, Raghavv, Shruthee Sankarlinkam, Sai Rakshana Karuppusami, Niraimathi Pandiyan, Suwetha Bharathirengan, Dinesh Kumar Subbiah, Soorya Srinivasan, Arockia Jayalatha Kulandaisamy i Noel Nesakumar. "Biomedical Applications of Nanoparticles". W Handbook of Research on Green Synthesis and Applications of Nanomaterials, 289–311. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8936-6.ch013.
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In recent years, there has been significant growth and burgeoning interest in utilizing nanoparticles for various biomedical applications, including medical diagnostics, targeted drug delivery, tissue engineering, regenerative medicine, and biomedical textiles. In particular, nanoparticles functionalized with biological molecules have unique properties and are very effective in medical diagnostics. Besides that, nanoparticles have a wide range of therapeutic applications, including the development of nanodrug delivery systems, the design of novel drugs, as well as their contribution to the design of therapeutic materials. This chapter provides an overview of recent advancements in the biomedical applications of nanoparticles. Finally, this chapter discusses the challenges of the toxicological evaluation of engineered nanoparticles and the importance of conducting detailed studies on the synthesis of future nanomaterials to develop cutting-edge technologies for addressing a wide range of biomedical issues.