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Shellcock, Carole. "Molecular aspects of algal biofuels". Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=217886.
Pełny tekst źródłaVanEngelen, Michael Robert. "Molecular aspects of uranium toxicity". Thesis, Montana State University, 2009. http://etd.lib.montana.edu/etd/2009/vanengelen/VanEngelenM1209.pdf.
Pełny tekst źródłaRakowski, Andrew George. "Molecular aspects of viroid activities /". Title page, contents and summary only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phr162.pdf.
Pełny tekst źródłaChauthaiwale, V. M. "Molecular aspects of chainia sp". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1992. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3005.
Pełny tekst źródłaGonçalves, Luiz Ricardo. "Detecção e caracterização molecular de espécies de Mycoplasma e Bartonella em roedores silvestres e sinantrópicos no Brasil /". Jaboticabal, 2016. http://hdl.handle.net/11449/141958.
Pełny tekst źródłaCoorientador: Rosangela Zacarias Machado
Banca: Paulo Eduardo Neves Ferreira Velho
Banca: José Maurício Barbanti Duarte
Resumo: Patógenos transmitidos por vetores artrópodes são mundialmente importantes, podendo causar enfermidades tanto no homen quanto nos animais. Recentemente, diversos estudos têm sido realizados a fim de elucidar o papel dos animais selvagens na epidemiologia desses patógenos. A identificação desses microrganismos, assim como dos seus vetores e hospedeiros, permite mapear áreas de ocorrência desses patógenos, auxiliando os órgãos competentes na elaboração de medidas de controle. Sendo assim, o presente estudo teve como objetivo detectar e caracterizar, por métodos moleculares, micoplasmas hemotróficos e bartonelas em amostras de baço de roedores selvagens e sinantrópicos distribuídos em cinco biomas brasileiros. Para tal, foram analisadas 500 amostras de roedores pertencentes a 51 espécies distribuídas em 13 estados. Dentre as 457 amostras de DNA positivas nos ensaios de PCR baseados nos genes Interphotoreceptor retinoid binding protein [IRBP] ou Glyceraldehyde-3-phosphate dehydrogenase [GAPDH], 100 (21,9%) mostraram-se positivas para Mycoplasma spp. por meio da cPCR baseada no gene 16S rRNA. A análise filogenética de 24 sequências do gene 16S rRNA mostrou a presença de dez diferentes clusters, todos agrupados dentro do grupo Mycoplasma haemofelis. O posicionamento filogenético associado com a baixa porcentagem de identidade entre as sequências amplificadas no presente estudo e aquelas previamente depositadas no Genbank sugere a circulação de novas espécies de hemoplasmas em roedo... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Arthropod-borne pathogens are wordwide important, causing diseases in humans and animals. Recently, several studies have been performed in order to elucidate the role of wild animals in the epidemiology of these pathogens. The identification of these microorganisms, as well as their vectors and hosts, allow to map the areas of occurrence of these pathogens, helping competent agencies in the development of control measures. Therefore, the present study aimed to detect and characterize, using molecular methods, hemotrophic mycoplasmas and Bartonella in wild and sinantropic rodent spleen samples distributed in five Brazilian biomes. For this purpose, 500 rodent samples belonging to 51 species distributed in 13 states were analyzed. Among 457 DNA samples positive to PCR assays based on the Interphotoreceptor retinoid binding protein [IRBP] or Glyceraldehyde-3-phosphate dehydrogenase [GAPDH]) genes, 100 (21.9%) were positive to Mycoplasma spp. by cPCR based on 16S rRNA gene. The phylogenetic analysis of 24 sequences of the 16S rRNA gene showed the presence of ten different clusters, which grouped within the Mycoplasma haemofelis group. The phylogenetic position associated with the low percentage of identity between the sequences amplified in the present study and those previously deposited in Genbank suggest the circulation of new hemoplasmas species in rodents in Brazil. Additionally, 117 (25.6%) samples were positive to Bartonella sp. by qPCR. The diversity analysis of the gltA ... (Complete abstract click electronic access below)
Mestre
Sörgjerd, Karin. "Molecular Aspects of Transthyretin Amyloid Disease". Doctoral thesis, Linköpings universitet, Biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12566.
Pełny tekst źródłaDenna avhandling handlar om proteiner. Särskilt de som inte fungerar som de ska utan har blivit vad man kallar ”felveckade”. Anledningen till att proteiner veckas fel beror ofta (men inte alltid) på mutationer i arvsmassan. Felveckade proteiner kan leda till sjukdomar hos människor och djur (man brukar tala om amyloidsjukdomar), ofta av neurologisk karaktär. Exempel på amyloidsjukdomar är polyneuropati, där perifera nervsystemet är drabbat, vilket leder till begränsad rörelseförmåga och senare till förlamning; och Alzheimer´s sjukdom, där centrala nervsystemet är drabbat och leder till begränsad tankeförmåga och minnesförluster. Studierna som presenteras i denna avhandling har gått ut på att få en bättre förståelse för hur felveckade proteiner interagerar med det som vi har naturligt i cellerna och som fungerar som skyddande, hjälpande proteiner, så kallade chaperoner. Transtyretin (TTR) är ett protein som cirkulerar i blodet och transporterar tyroxin (som är ett hormon som bland annat har betydelse för ämnesomsättningen) samt retinol-bindande protein (vitamin A). I TTR genen har man funnit över 100 punktmutationer, vilka har kopplats samman med amyloidsjukdomar, bland annat ”Skellefteåsjukan”. Mutationer i TTR genen leder ofta till att proteinet blir instabilt vilket leder till upplösning av TTR tetrameren till monomerer. Dessa monomerer kan därefter sammanfogas på nytt men denna gång på ett sätt som är farligt för organismen. I denna avhandling har fokus legat på en mutation som kallas TTR D18G, vilken har identifierats i olika delar av världen och leder till en dödlig form av amyloidos i centrala nervsystemet. Det chaperon som vi har studerat benämns BiP och är beläget i en cellkomponent som kallas för det endoplasmatiska retiklet (ER). I ER finns cellens kontrollsystem i vilket det ses till att felveckade proteiner inte släpps ut utan istället bryts ned. Denna avhandling har visat att BiP kan fånga upp TTR D18G inuti celler och där samla mutanten i lösliga partiklar som i detta fall är ofarliga för cellen. Avhandligen har också visat att nedbrytningen av TTR D18G sker mycket långsammare när BiP finns i riklig mängd.
Broomand, Amir. "Molecular aspects on voltage-sensor movement". Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1028s.pdf.
Pełny tekst źródłaNjålsson, Runa Viđarr. "Molecular aspects of glutathione synthetase deficiency /". Stockholm, 2004. http://diss.kib.ki.se/2003/91-7349-808-4.
Pełny tekst źródłaFawcett, Jonathan. "Molecular aspects of angiogenesis and metastasis". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386753.
Pełny tekst źródłaWatkins, Craig Allen. "Molecular aspects of punta toro virus". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239272.
Pełny tekst źródłaAmako, Katsumi. "MOLECULAR ASPECTS OF ASCORBATE PEROXIDASE ISOZYMES". Kyoto University, 1997. http://hdl.handle.net/2433/202393.
Pełny tekst źródła0048
新制・課程博士
博士(農学)
甲第6912号
農博第930号
新制||農||741(附属図書館)
学位論文||H9||N3036(農学部図書室)
16029
UT51-97-H296
京都大学大学院農学研究科農芸化学専攻
(主査)教授 淺田 浩二, 教授 池田 篤治, 教授 佐藤 文彦
学位規則第4条第1項該当
Ballana, Guix Ester. "Molecular basis of deafness linked to mitochondrial DNA mutations". Doctoral thesis, Universitat Pompeu Fabra, 2007. http://hdl.handle.net/10803/7113.
Pełny tekst źródłaLeida, Carmen Alice. "Molecular aspects of dormancy in peach (Prunus persica [L.] Batsch.)". Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/15864.
Pełny tekst źródłaLeida, CA. (2012). Molecular aspects of dormancy in peach (Prunus persica [L.] Batsch.) [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/15864
Palancia
Cuendet, Michel Alain. "Aspects of thermostated and nonautonomous molecular dynamics /". Zürich : ETH, 2006. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16863.
Pełny tekst źródłaLaberge, MacDonald Tammy. "Molecular Aspects of Nitrogen Metabolism in Fishes". Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/668.
Pełny tekst źródłaWaghorn, Tania Susanne. "Molecular and Ecological Aspects of Heliothis Armigera". Thesis, University of Auckland, 1999. http://hdl.handle.net/2292/522.
Pełny tekst źródłaLidén, Martin. "Molecular aspects of retinol uptake and activation /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-556-9/.
Pełny tekst źródłaHenriksson, Mikael. "Molecular aspects of proinsulin C-peptide interactions /". Stockholm : Department of medical biochemistry and biophysics, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-754-5/.
Pełny tekst źródłaJosephson, Anna. "Spinal cord injury: mechanical and molecular aspects /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-235-3/.
Pełny tekst źródłaFransén, Karin. "Molecular genetic aspects of colorectal cancer development /". Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med878s.pdf.
Pełny tekst źródłaVaz, Frédéric Maxime. "Molecular and biochemical aspects of carnitine biosynthesis". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64280.
Pełny tekst źródłaLovat, Laurence Bruce. "Molecular, therapeutic and clinical aspects of amyloidosis". Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400220.
Pełny tekst źródła梁杏媚 i Hang-mei Polly Leung. "Cellular and molecular aspects of myelodysplastic syndromes". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31211628.
Pełny tekst źródłaAsztalos, SzilaÌrd. "Molecular aspects of resistance to Orobanche species". Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425596.
Pełny tekst źródłaChaudhry, Shazia A. "Molecular aspects of poliovirus pathogenesis and virulence". Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283788.
Pełny tekst źródłaAlfirevic, Ana. "Molecular aspects of carbamazepine-induced hypersensitivity reactions". Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421067.
Pełny tekst źródłaSochi, T. "Atomic and molecular aspects of astronomical spectra". Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1369696/.
Pełny tekst źródłaMatthew, Caroline Zoe. "Biological and molecular aspects of Sodalis glossinidius". Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29872.
Pełny tekst źródłaRebholz, Wilhelmus Ewald Reinaard. "Molecular phylogenetics and conservation aspects of antelopes". Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26971.
Pełny tekst źródłaWestwater, Caroline. "Molecular aspects of mannosyltransferases in Candida albicans". Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU543392.
Pełny tekst źródłaLeung, Hang-mei Polly. "Cellular and molecular aspects of myelodysplastic syndromes /". [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13781455.
Pełny tekst źródłaIp, Julian Chung Yan. "Clinical and molecular aspects of adrenal tumourigenesis". Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13738.
Pełny tekst źródłaRodger, Alison. "Molecular aspects of biomolecule structure and function". Thesis, The University of Sydney, 2002. http://hdl.handle.net/2123/516.
Pełny tekst źródłaRodger, Alison. "Molecular aspects of biomolecule structure and function". University of Sydney. Chemistry, 2002. http://hdl.handle.net/2123/516.
Pełny tekst źródłaJenkins, Timothy Mark. "Molecular and metabolic aspects of succinate thiokinase". Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383299.
Pełny tekst źródłaWolters, Pieter Jacobus. "Molecular aspects of columnar growth in apple". Doctoral thesis, country:NL, 2014. http://hdl.handle.net/10449/26757.
Pełny tekst źródłaCHIRIACO, MARIA. "Molecular and biological aspects of primary immunodeficiency". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1126.
Pełny tekst źródłaBackground: Primary immunodeficiency diseases (PIDs) comprise a genetically heterogeneous group of disorders which affect distinct components of the innate and adaptive immune system. Over 120 distinct genes have been identified, whose abnormalities account for more than 150 different forms of PID. Clinical presentation is highly variable; actually ranging from various patterns of microbial susceptibility to allergy, lymphoproliferation or autoimmune manifestations. The study of patients affected by immunodeficiencies allows to identify new genes involved in the immune response indeed PIDs represent an optimal model to investigate development, function and regulation mechanisms of immune system. Aim of the study: To define a rational approach to recognize immune deficiencies, with specific emphasis on developing clinical evaluations, understanding the genetic and cellular basis of the disease (Study1 and Study 2), and propose a gene therapy approach as a definitive cure of immunodeficiency due to a defined genic defect (Study3). study1: We report a patient with dysgammaglobulinemia, and gradual decrease of peripheral B lymphocytes. A new Btk mutation was identified in this patient and protein expression was determined. Although clinical and laboratory history is not totally inconsistent with an atypical variant of XLA, it is unclear if all the clinical presentation/picture is influenced by the new mutation. Study2: We report for the first time a case of a female patient with combined immunodeficiency characterised by a complete absence of B cells and NK cells, and their progenitors. Surprisingly, she had an absence of monocytes (CD14+) and DC cells. Direct sequencing of genomic and cDNA of Flt3L, Flt3R, and of major genes (Ikaros and of PU.1) regulating the FLT3-FLT3L expression did not show the presence of any mutations. Levels of Flt3R and Flt3L mRNA in peripheral blood resulted significantly higher (10- and 30- fold increase respectively) with respect to healthy control donor, supporting the hypothesis of an inherited imbalance in the expression of Flt3 ligand mRNA. This finding, in addition to a normal stromal function highlights the possibility of a more specific therapeutic strategy in this child, such as haematopoietic stem cells transplantation. Study3: Gene therapy could represent a definitive cure for patients for whom conventional HSCT is not available. Several clinical trials on XCGD-gene therapy have been conducted since 1997, but they resulted in low and short-term engraftment of CGD-corrected cells. In this study we develop a new strategy for XCGD gene therapy with stem cells, including Lentiviral Vector (LVV) design and microRNA technology, for a safe and effective treatment of X-CGD.
Ragazzon, Giulio <1989>. "Operating Molecular Machines: Thermodynamic and Kinetic Aspects". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/8043/1/Ragazzon_PhDThesis.pdf.
Pełny tekst źródłaRawat, U. B. "Biochemical and molecular aspects of neurospora crassa". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1998. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3385.
Pełny tekst źródłaTanksale, A. M. "Molecular aspects of a fungal alkaline protease". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2001. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2897.
Pełny tekst źródłaGeorge, S. P. "Molecular and biochemical aspects of extremophilic actinomycete". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2001. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2315.
Pełny tekst źródłaCheng, Yin-wo, i 鄭燕和. "Molecular basis for the increased osteoblast activity in a mouse modelwith hyperostosis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34612981.
Pełny tekst źródła武廣文 i Guangwen Wu. "Molecular simulation studies of platinum and oxygen on a graphite surface". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31236315.
Pełny tekst źródła彭志明 i Chi-ming Pang. "Molecular analysis of the dehalogenase IVa of Burkholderia cepacia MBA4". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31240872.
Pełny tekst źródłaHigaki, Sayuri. "Molecular aspects of brain aging in female macaques". 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157838.
Pełny tekst źródłaMallon, Patrick William Gerard School of Medicine UNSW. "Clinical and molecular aspects of HIV-associated lipodystrophy". Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/33048.
Pełny tekst źródłaFeng, Jianrong. "Molecular and environmental aspects of latex film formation". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0008/NQ28278.pdf.
Pełny tekst źródłaTopalović, Tatjana. "Catalytic bleaching of cotton: molecular and macroscopic aspects". Enschede : University of Twente [Host], 2006. http://doc.utwente.nl/57688.
Pełny tekst źródłaAlimov, Andrei. "Molecular genetic aspects of renal cell carcinoma development /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-559-X/.
Pełny tekst źródłaStark, Lisa. "Staphylococcus aureus : aspects of pathogenesis and molecular epidemiology". Doctoral thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97343.
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