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Artykuły w czasopismach na temat „Molecular adhesion”

Autor: Grafiati

Data publikacji: 8 czerwca 2024

Data aktualizacji: 31 lipca 2025

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1

Mentzer, S. J., D. V. Faller, and S. J. Burakoff. "Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes." Journal of Immunology 137, no. 1 (1986): 108–13. http://dx.doi.org/10.4049/jimmunol.137.1.108.

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Abstract Cell-cell adhesion plays an important role in monocyte function. To investigate the molecular basis for monocyte adhesion, we used recombinant interferon-gamma to induce the formation of homotypic monocyte adhesions. The induction of homotypic adhesions correlated with the increased expression of the LFA-1 membrane molecule. LFA-1 surface expression was increased twofold, whereas expression levels of other monocyte surface molecules including CR3 and p150,95 were unchanged. The direct involvement of LFA-1 in monocyte adhesion was addressed by anti-LFA-1 monoclonal antibody inhibition

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2

Willaert, Ronnie G., Yeseren Kayacan, and Bart Devreese. "The Flo Adhesin Family." Pathogens 10, no. 11 (2021): 1397. http://dx.doi.org/10.3390/pathogens10111397.

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The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechan

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3

Taylor, James T., Rebekka Harting, Samer Shalaby, Charles M. Kenerley, Gerhard H. Braus, and Benjamin A. Horwitz. "Adhesion as a Focus in Trichoderma–Root Interactions." Journal of Fungi 8, no. 4 (2022): 372. http://dx.doi.org/10.3390/jof8040372.

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Fungal spores, germlings, and mycelia adhere to substrates, including host tissues. The adhesive forces depend on the substrate and on the adhesins, the fungal cell surface proteins. Attachment is often a prerequisite for the invasion of the host, hence its importance. Adhesion visibly precedes colonization of root surfaces and outer cortex layers, but little is known about the molecular details. We propose that by starting from what is already known from other fungi, including yeast and other filamentous pathogens and symbionts, the mechanism and function of Trichoderma adhesion will become a

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Willaert, Ronnie. "Adhesins of Yeasts: Protein Structure and Interactions." Journal of Fungi 4, no. 4 (2018): 119. http://dx.doi.org/10.3390/jof4040119.

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The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast Saccharomyces cerevisiae can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces. Infectious yeast diseases such as candidiasis are initiated by the adhesion of the yeast cells to host cells. Adhesion is accomplished by adhesin proteins that are attached to the cell wall and stick out to interact with other cells or substrates. Protein structures give d

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5

Bach, Cuc T. T., Sarah Creed, Jessie Zhong, et al. "Tropomyosin Isoform Expression Regulates the Transition of Adhesions To Determine Cell Speed and Direction." Molecular and Cellular Biology 29, no. 6 (2009): 1506–14. http://dx.doi.org/10.1128/mcb.00857-08.

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ABSTRACT The balance of transition between distinct adhesion types contributes to the regulation of mesenchymal cell migration, and the characteristic association of adhesions with actin filaments led us to question the role of actin filament-associating proteins in the transition between adhesive states. Tropomyosin isoform association with actin filaments imparts distinct filament structures, and we have thus investigated the role for tropomyosins in determining the formation of distinct adhesion structures. Using combinations of overexpression, knockdown, and knockout approaches, we establi

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6

Labbate, Maurizio, Hua Zhu, Leena Thung, et al. "Quorum-Sensing Regulation of Adhesion in Serratia marcescens MG1 Is Surface Dependent." Journal of Bacteriology 189, no. 7 (2007): 2702–11. http://dx.doi.org/10.1128/jb.01582-06.

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ABSTRACT Serratia marcescens is an opportunistic pathogen and a major cause of ocular infections. In previous studies of S. marcescens MG1, we showed that biofilm maturation and sloughing were regulated by N-acyl homoserine lactone (AHL)-based quorum sensing (QS). Because of the importance of adhesion in initiating biofilm formation and infection, the primary goal of this study was to determine whether QS is important in adhesion to both abiotic and biotic surfaces, as assessed by determining the degree of attachment to hydrophilic tissue culture plates and human corneal epithelial (HCE) cells

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7

TAKASHIMA, Yoshinori, Motofumi OSAKI, Tomoko SEKINE, Yasushi SHOJIMA, and Akira HARADA. "Materials Adhesion Based on Molecular Adhesive Techniques." Journal of The Adhesion Society of Japan 54, no. 6 (2018): 201–11. http://dx.doi.org/10.11618/adhesion.54.201.

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8

Young, Katherine A., Laura Biggins, and Hayley J. Sharpe. "Protein tyrosine phosphatases in cell adhesion." Biochemical Journal 478, no. 5 (2021): 1061–83. http://dx.doi.org/10.1042/bcj20200511.

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Adhesive structures between cells and with the surrounding matrix are essential for the development of multicellular organisms. In addition to providing mechanical integrity, they are key signalling centres providing feedback on the extracellular environment to the cell interior, and vice versa. During development, mitosis and repair, cell adhesions must undergo extensive remodelling. Post-translational modifications of proteins within these complexes serve as switches for activity. Tyrosine phosphorylation is an important modification in cell adhesion that is dynamically regulated by the prot

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9

Simmons, David L. "Dissecting the modes of interactions amongst cell adhesion molecules." Development 119, Supplement (1993): 193–203. http://dx.doi.org/10.1242/dev.119.supplement.193.

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The process of cell adhesion can be mediated by more than SO molecules. Fortunately, most of these can be grouped into a small number of super families. For example, more than half of all leukocyte adhesion molecules are members of the immunoglobulin super-family. The principles of cell-cell adhesion are reviewed including: kinetics and equilibria; on/off rates; affinities/avidities; homotypic/heterotypic interactions; mapping and delineation of binding sites. These principles are illustrated with two CAMs: firstly the interaction of the homotypic epithelial/myeloid adhesins CD66, and the endo

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10

Saed, Ghassan M., and Michael P. Diamond. "Molecular Characterization of Postoperative Adhesions: The Adhesion Phenotype." Journal of the American Association of Gynecologic Laparoscopists 11, no. 3 (2004): 307–14. http://dx.doi.org/10.1016/s1074-3804(05)60041-2.

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11

Hall, Jeffrey W., Bruno P. Lima, Gaetan G. Herbomel, et al. "An intramembrane sensory circuit monitors sortase A–mediated processing of streptococcal adhesins." Science Signaling 12, no. 580 (2019): eaas9941. http://dx.doi.org/10.1126/scisignal.aas9941.

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Bacterial adhesins mediate adhesion to substrates and biofilm formation. Adhesins of the LPXTG family are posttranslationally processed by the cell membrane–localized peptidase sortase A, which cleaves the LPXTG motif. This generates a short C-terminal peptide (C-pep) that remains in the cell membrane, whereas the mature adhesin is incorporated into the cell wall. Genes encoding adhesins of the oral bacteriumStreptococcus gordoniiwere differentially expressed depending on whether the bacteria were isolated from saliva or dental plaque and appeared to be coordinately regulated. Deletion ofsspAa

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12

Iwasaki, T., and H. Miura. "Molecular dynamics analysis of adhesion strength of interfaces between thin films." Journal of Materials Research 16, no. 6 (2001): 1789–94. http://dx.doi.org/10.1557/jmr.2001.0247.

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We have developed a molecular-dynamics technique for determining the adhesion strength of the interfaces between different materials. This technique evaluates the adhesion strength by calculating the adhesive fracture energy defined as the difference between the total potential energy of the material-connected state and that of the material-separated state. The extended Tersoff-type potential is applied to calculate the adhesive fracture energy of metal/dielectric interfaces as well as metal/metal interfaces. We used the technique to determine the adhesion strength of the interfaces between UL

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13

Katoh, Kazuo. "FAK-Dependent Cell Motility and Cell Elongation." Cells 9, no. 1 (2020): 192. http://dx.doi.org/10.3390/cells9010192.

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Fibroblastic cells show specific substrate selectivity for typical cell–substrate adhesion. However, focal adhesion kinase (FAK) contributes to controlling the regulation of orientation and polarity. When fibroblasts attach to micropatterns, tyrosine-phosphorylated proteins and FAK are both detected along the inner border between the adhesive micropatterns and the nonadhesive glass surface. FAK likely plays important roles in regulation of cell adhesion to the substrate, as FAK is a tyrosine-phosphorylated protein that acts as a signal transduction molecule at sites of cell–substrate attachmen

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14

Zamir, E., B. Z. Katz, S. Aota, K. M. Yamada, B. Geiger, and Z. Kam. "Molecular diversity of cell-matrix adhesions." Journal of Cell Science 112, no. 11 (1999): 1655–69. http://dx.doi.org/10.1242/jcs.112.11.1655.

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In this study we have examined for molecular heterogeneity of cell-matrix adhesions and the involvement of actomyosin contractility in the selective recruitment of different plaque proteins. For this purpose, we have developed a novel microscopic approach for molecular morphometry, based on automatic identification of matrix adhesions, followed by quantitative immunofluorescence and morphometric analysis. Particularly informative was fluorescence ratio imaging, comparing the local labeling intensities of different plaque molecules, including vinculin, paxillin, tensin and phosphotyrosine-conta

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15

von Fraunhofer, J. Anthony. "Adhesion and Cohesion." International Journal of Dentistry 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/951324.

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The phenomena of adhesion and cohesion are reviewed and discussed with particular reference to dentistry. This review considers the forces involved in cohesion and adhesion together with the mechanisms of adhesion and the underlying molecular processes involved in bonding of dissimilar materials. The forces involved in surface tension, surface wetting, chemical adhesion, dispersive adhesion, diffusive adhesion, and mechanical adhesion are reviewed in detail and examples relevant to adhesive dentistry and bonding are given. Substrate surface chemistry and its influence on adhesion, together wit

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16

Ciobanasu, Corina, Bruno Faivre, and Christophe Le Clainche. "Actin Dynamics Associated with Focal Adhesions." International Journal of Cell Biology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/941292.

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Cell-matrix adhesion plays a major role during cell migration. Proteins from adhesion structures connect the extracellular matrix to the actin cytoskeleton, allowing the growing actin network to push the plasma membrane and the contractile cables (stress fibers) to pull the cell body. Force transmission to the extracellular matrix depends on several parameters including the regulation of actin dynamics in adhesion structures, the contractility of stress fibers, and the mechanosensitive response of adhesion structures. Here we highlight recent findings on the molecular mechanisms by which actin

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17

Kikuchi, Kiyoshi, Kentaro Setoyama, Seiya Takada, et al. "E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model." International Journal of Molecular Sciences 21, no. 11 (2020): 3972. http://dx.doi.org/10.3390/ijms21113972.

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Perineural adhesions leading to neuropathy are one of the most undesirable consequences of peripheral nerve surgery. However, there are currently no widely used compounds with anti-adhesive effects in the field of peripheral nerve surgery. E8002 is a novel, anti-adhesive, multi-layer membrane that contains L-ascorbic acid (AA). Here, we investigated the effect and mechanism of E8002 in a rat sciatic nerve adhesion model. A total of 21 rats were used. Six weeks after surgery, macroscopic adhesion scores were significantly lower in the E8002 group (adhesion procedure followed by nerve wrapping w

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18

Tam, Lik-ho, and Denvid Lau. "Molecular simulation of adhesion property recovery in the cellulose/phenolic adhesive interface: the role of water molecules." MRS Proceedings 1793 (2015): 59–66. http://dx.doi.org/10.1557/opl.2015.826.

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ABSTRACTCellulose is one of the most abundant substances in the world, and the major constituent in the wood structure. Phenolic adhesive is largely used in the wood manufacture for gluing the wood panels together. The cellulose/phenolic adhesive interface is a representative of the interface between the wood panels and adhesives in the wood products. As the wood panels and adhesive are sensitive to environmental humidity, the interfacial adhesion of such interface when subjected to a humid environment can be a major factor in the durability of final products. Here, the role of water molecules

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19

Westhoff, M. A., B. Serrels, V. J. Fincham, M. C. Frame, and N. O. Carragher. "Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling." Molecular and Cellular Biology 24, no. 18 (2004): 8113–33. http://dx.doi.org/10.1128/mcb.24.18.8113-8133.2004.

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ABSTRACT Integrin-associated focal adhesions not only provide adhesive links between cellular actin and extracellular matrix but also are sites of signal transmission into the cell interior. Many cell responses signal through focal adhesion kinase (FAK), often by integrin-induced autophosphorylation of FAK or phosphorylation by Src family kinases. Here, we used an interfering FAK mutant (4-9F-FAK) to show that Src-dependent FAK phosphorylation is required for focal adhesion turnover and cell migration, by controlling assembly of a calpain 2/FAK/Src/p42ERK complex, calpain activation, and prote

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20

Tees, David F. J., and Douglas J. Goetz. "Leukocyte Adhesion: An Exquisite Balance of Hydrodynamic and Molecular Forces." Physiology 18, no. 5 (2003): 186–90. http://dx.doi.org/10.1152/nips.01444.2003.

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Leukocyte adhesion to the vascular endothelium involves a disruptive force exerted on the leukocyte by the flow of the blood and an adhesive force that forms at the leukocyte-endothelial interface. The relative strengths of these two competing forces govern leukocyte adhesion.

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21

PARK, Hee Boong, Vita GOLUBOVSKAYA, Lihui XU, et al. "Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells." Biochemical Journal 378, no. 2 (2004): 559–67. http://dx.doi.org/10.1042/bj20031392.

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Focal adhesion kinase (FAK) is an intracellular kinase that localizes to focal adhesions. FAK is overexpressed in human tumours, and FAK regulates both cellular adhesion and anti-apoptotic survival signalling. Disruption of FAK function by overexpression of the FAK C-terminal domain [FAK-CD, analogous to the FRNK (FAK-related non-kinase) protein] leads to loss of adhesion and apoptosis in tumour cells. We have shown that overexpression of an activated form of the Src tyrosine kinase suppressed the loss of adhesion induced by dominant-negative; adenoviral FAK-CD and decreased the apoptotic resp

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22

Petrie, Laurenne E., Allison C. Leonard, Julia Murphy, and Georgina Cox. "Development and validation of a high-throughput whole cell assay to investigate Staphylococcus aureus adhesion to host ligands." Journal of Biological Chemistry 295, no. 49 (2020): 16700–16712. http://dx.doi.org/10.1074/jbc.ra120.015360.

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Staphylococcus aureus adhesion to the host's skin and mucosae enables asymptomatic colonization and the establishment of infection. This process is facilitated by cell wall-anchored adhesins that bind to host ligands. Therapeutics targeting this process could provide significant clinical benefits; however, the development of anti-adhesives requires an in-depth knowledge of adhesion-associated factors and an assay amenable to high-throughput applications. Here, we describe the development of a sensitive and robust whole cell assay to enable the large-scale profiling of S. aureus adhesion to hos

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23

Lipke, Peter N., and Peleg Ragonis-Bachar. "Sticking to the Subject: Multifunctionality in Microbial Adhesins." Journal of Fungi 9, no. 4 (2023): 419. http://dx.doi.org/10.3390/jof9040419.

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Bacterial and fungal adhesins mediate microbial aggregation, biofilm formation, and adhesion to host. We divide these proteins into two major classes: professional adhesins and moonlighting adhesins that have a non-adhesive activity that is evolutionarily conserved. A fundamental difference between the two classes is the dissociation rate. Whereas moonlighters, including cytoplasmic enzymes and chaperones, can bind with high affinity, they usually dissociate quickly. Professional adhesins often have unusually long dissociation rates: minutes or hours. Each adhesin has at least three activities

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Winograd-Katz, Sabina E., Shalev Itzkovitz, Zvi Kam, and Benjamin Geiger. "Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown." Journal of Cell Biology 186, no. 3 (2009): 423–36. http://dx.doi.org/10.1083/jcb.200901105.

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Cell adhesion to the extracellular matrix is mediated by elaborate networks of multiprotein complexes consisting of adhesion receptors, cytoskeletal components, signaling molecules, and diverse adaptor proteins. To explore how specific molecular pathways function in the assembly of focal adhesions (FAs), we performed a high-throughput, high-resolution, microscopy-based screen. We used small interfering RNAs (siRNAs) to target human kinases, phosphatases, and migration- and adhesion-related genes. Multiparametric image analysis of control and of siRNA-treated cells revealed major correlations b

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25

Guo, Jianhua, Niping Ma, Jiale Chen, and Ning Wei. "Efficient Non-Destructive Detection of Interface Adhesion State by Interfacial Thermal Conductance: A Molecular Dynamics Study." Processes 11, no. 4 (2023): 1032. http://dx.doi.org/10.3390/pr11041032.

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The state of interface adhesion, as measured by the void ratio, is a critical factor affecting the adhesion strength and heat dissipation efficiency of a system. However, non-destructive and rapid detection of the adhesion process remains a challenge. In this study, we used all-atom molecular dynamics simulations to investigate the interfacial thermal conductance of silicon and polymer at various adhesion void ratios, with the aim of achieving non-destructive and rapid detection of the adhesion process. Our results demonstrate a linear relationship between the interfacial thermal conductance a

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26

Revach, Or-Yam, Inna Grosheva, and Benjamin Geiger. "Biomechanical regulation of focal adhesion and invadopodia formation." Journal of Cell Science 133, no. 20 (2020): jcs244848. http://dx.doi.org/10.1242/jcs.244848.

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ABSTRACTIntegrin adhesions are a structurally and functionally diverse family of transmembrane, multi-protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM). The different members of this family, including focal adhesions (FAs), focal complexes, fibrillar adhesions, podosomes and invadopodia, contain many shared scaffolding and signaling ‘adhesome’ components, as well as distinct molecules that perform specific functions, unique to each adhesion form. In this Hypothesis, we address the pivotal roles of mechanical forces, generated by local actin polymeriza

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Smith, Wendy D., Jonathan A. Pointon, Emily Abbot, et al. "Roles of Minor Pilin Subunits Spy0125 and Spy0130 in the Serotype M1 Streptococcus pyogenes Strain SF370." Journal of Bacteriology 192, no. 18 (2010): 4651–59. http://dx.doi.org/10.1128/jb.00071-10.

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ABSTRACT Adhesive pili on the surface of the serotype M1 Streptococcus pyogenes strain SF370 are composed of a major backbone subunit (Spy0128) and two minor subunits (Spy0125 and Spy0130), joined covalently by a pilin polymerase (Spy0129). Previous studies using recombinant proteins showed that both minor subunits bind to human pharyngeal (Detroit) cells (A. G. Manetti et al., Mol. Microbiol. 64:968-983, 2007), suggesting both may act as pilus-presented adhesins. While confirming these binding properties, studies described here indicate that Spy0125 is the pilus-presented adhesin and that Spy

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Ho, May, and Nicholas J. White. "Molecular mechanisms of cytoadherence in malaria." American Journal of Physiology-Cell Physiology 276, no. 6 (1999): C1231—C1242. http://dx.doi.org/10.1152/ajpcell.1999.276.6.c1231.

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Microbial pathogens subvert host adhesion molecules to disseminate or to enter host cells to promote their own survival. One such subversion is the cytoadherence of Plasmodium falciparum-infected erythrocytes (IRBC) to vascular endothelium, which protects the parasite from being removed by the spleen. The process results in microcirculatory obstruction and subsequent hypoxia, metabolic disturbances, and multiorgan failure, which are detrimental to the host. Understanding the molecular events involved in these adhesive interactions is therefore critical both in terms of pathogenesis and implica

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Gallant, Nathan D., Kristin E. Michael, and Andrés J. García. "Cell Adhesion Strengthening: Contributions of Adhesive Area, Integrin Binding, and Focal Adhesion Assembly." Molecular Biology of the Cell 16, no. 9 (2005): 4329–40. http://dx.doi.org/10.1091/mbc.e05-02-0170.

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Mechanical interactions between a cell and its environment regulate migration, contractility, gene expression, and cell fate. We integrated micropatterned substrates to engineer adhesive area and a hydrodynamic assay to analyze fibroblast adhesion strengthening on fibronectin. Independently of cell spreading, integrin binding and focal adhesion assembly resulted in rapid sevenfold increases in adhesion strength to steady-state levels. Adhesive area strongly modulated adhesion strength, integrin binding, and vinculin and talin recruitment, exhibiting linear increases for small areas. However, a

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Lungu, Mirela, Claudiu N. Lungu, Andreea Creteanu, and Mihaela C. Mehedinti. "Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion." Current Issues in Molecular Biology 47, no. 6 (2025): 475. https://doi.org/10.3390/cimb47060475.

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Peritoneal adhesions following surgical injury remain a major clinical challenge, often resulting in severe complications, such as intestinal obstruction, chronic pain, and infertility. This review systematically integrates recent genomic and molecular biology insights into the pathogenesis of peritoneal adhesions, explicitly focusing on molecular pathways, including TGF-β signaling, COX-2-mediated inflammatory responses, fibrinolytic balance (tPA/PAI-1), angiogenesis pathways (VEGF, PDGF), and extracellular matrix remodeling (MMPs/TIMPs). Newly conducted transcriptomic and proteomic analyses

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Herrick, Sarah E., and Bettina Wilm. "Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms." Biomolecules 11, no. 5 (2021): 692. http://dx.doi.org/10.3390/biom11050692.

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Post-surgical adhesions are internal scar tissue and a major health and economic burden. Adhesions affect and involve the peritoneal lining of the abdominal cavity, which consists of a continuous mesothelial covering of the cavity wall and majority of internal organs. Our understanding of the full pathophysiology of adhesion formation is limited by the fact that the mechanisms regulating normal serosal repair and regeneration of the mesothelial layer are still being elucidated. Emerging evidence suggests that mesothelial cells do not simply form a passive barrier but perform a wide range of im

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Kesel, S., A. Mader, P. H. Seeberger, O. Lieleg, and M. Opitz. "Carbohydrate Coating Reduces Adhesion of Biofilm-Forming Bacillus subtilis to Gold Surfaces." Applied and Environmental Microbiology 80, no. 19 (2014): 5911–17. http://dx.doi.org/10.1128/aem.01600-14.

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ABSTRACTThe growth of bacterial biofilms in pipes and food tanks causes severe problems in industry. Biofilms growing on medical implants or catheters are of great concern, as they can cause serious infections and decrease the functionality of the medical device. The prevention of bacterial adhesion—the first step in colonization and biofilm formation—is therefore very important. Current research comprises alterations in surface properties, the prevention of adhesin biosynthesis, inhibition with receptor analogs, or the development of anti-adhesive vaccines. We present a new approach that allo

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Mintz, Keith P. "Identification of an extracellular matrix protein adhesin, EmaA, which mediates the adhesion of Actinobacillus actinomycetemcomitans to collagen." Microbiology 150, no. 8 (2004): 2677–88. http://dx.doi.org/10.1099/mic.0.27110-0.

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Actinobacillus actinomycetemcomitans is an aetiologic agent in the development of periodontal and some systemic diseases in humans. This pathogen localizes to the underlying connective tissue of the oral cavity in individuals with periodontal disease. The adhesion of A. actinomycetemcomitans to extracellular matrix components of the connective tissue prompted this study to identify gene products mediating the interaction of A. actinomycetemcomitans to these molecules. A transposon mutagenesis system was optimized for use in A. actinomycetemcomitans and used to generate an insertional mutant li

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Kirchgatter, Karin, and Hernando A. Del Portillo. "Clinical and molecular aspects of severe malaria." Anais da Academia Brasileira de Ciências 77, no. 3 (2005): 455–75. http://dx.doi.org/10.1590/s0001-37652005000300008.

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The erythrocytic cycle of Plasmodium falciparum presents a particularity in relation to other Plasmodium species that infect man. Mature trophozoites and schizonts are sequestered from the peripheral circulation due to adhesion of infected erythrocytes to host endothelial cells. Modifications in the surface of infected erythrocytes, termed knobs, seem to facilitate adhesion to endothelium and other erythrocytes. Adhesion provides better maturation in the microaerophilic venous atmosphere and allows the parasite to escape clearance by the spleen which recognizes the erythrocytes loss of deforma

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Byvalov, A. A., and I. V. Konyshev. "Yersinia pseudotuberculosis-derived adhesins." Russian Journal of Infection and Immunity 9, no. 3-4 (2019): 437–48. http://dx.doi.org/10.15789/2220-7619-2019-3-4-437-448.

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Around fifteen surface components referred to adhesins have been identified in Yersinia pseudotuberculosis combining primarily microbiological, molecular and genetic, as well as immunochemical and biophysical methods. Y. pseudotuberculosis-derived adhesins vary in structure and chemical composition but they are mainly presented by protein molecules. Some of them were shown to participate not only in adhesive but in other pathogen-related physiological functions in the host-parasite interplay. Adhesins can mediate bacterial adhesion to eukaryotic cell either directly or via the extracellular ma

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Kang, Victor, Birgit Lengerer, Ruddy Wattiez, and Patrick Flammang. "Molecular insights into the powerful mucus-based adhesion of limpets ( Patella vulgata L.)." Open Biology 10, no. 6 (2020): 200019. http://dx.doi.org/10.1098/rsob.200019.

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Limpets ( Patella vulgata L.) are renowned for their powerful attachments to rocks on wave-swept seashores. Unlike adult barnacles and mussels, limpets do not adhere permanently; instead, they repeatedly transition between long-term adhesion and locomotive adhesion depending on the tide. Recent studies on the adhesive secretions (bio-adhesives) of marine invertebrates have expanded our knowledge on the composition and function of temporary and permanent bio-adhesives. In comparison, our understanding of the limpets' transitory adhesion remains limited. In this study, we demonstrate that suctio

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Wu, Ziwei, Zhipeng Li, Yixiao Li, Haoyu Wang, Jiang Yue, and Tieling Xing. "Biomimetic Design of Underwater Adhesives Based on Tea Polyphenol-Modified Gelatin." Biomimetics 10, no. 3 (2025): 149. https://doi.org/10.3390/biomimetics10030149.

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Although many tissue adhesives with good biocompatibility are currently available, their lack of wet adhesion capacity significantly hinders their clinical application. Therefore, further development and exploration of new medical adhesives are necessary. Inspired by the adhesion mechanism of marine mussels, through modifying gelatin protein with gallic acid (GA) for wet adhesion and cross-linking gelatin (Gel) molecular chains with tea polyphenols (TP), the adhesive TP-GA/Gel was developed. The adhesive exhibited an adhesion strength of up to 130.47 kPa to porcine skin tissues and maintained

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ENDO, Takeshi, and Atsushi SUDO. "Designs of Functional Materials -From Molecular Design to Molecular Engineering for Industrial Production." Journal of The Adhesion Society of Japan 49, no. 2 (2013): 63–69. http://dx.doi.org/10.11618/adhesion.49.63.

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MORI, Kunio. "The 21th Century Adhesion Technorogy - Molecular Adhesives -." Journal of The Adhesion Society of Japan 43, no. 6 (2007): 242–48. http://dx.doi.org/10.11618/adhesion.43.242.

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Bradley, William D., Samuel E. Hernández, Jeffrey Settleman, and Anthony J. Koleske. "Integrin Signaling through Arg Activates p190RhoGAP by Promoting Its Binding to p120RasGAP and Recruitment to the Membrane." Molecular Biology of the Cell 17, no. 11 (2006): 4827–36. http://dx.doi.org/10.1091/mbc.e06-02-0132.

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The Rho family GTPases RhoA (Rho), Rac1, and Cdc42 are essential effectors of integrin-mediated cell attachment and spreading. Rho activity, which promotes formation of focal adhesions and actin stress fibers, is inhibited upon initial cell attachment to allow sampling of the new adhesive environment. The Abl-related gene (Arg) tyrosine kinase mediates adhesion-dependent inhibition of Rho through phosphorylation and activation of the Rho inhibitor p190RhoGAP-A (p190). p190 phosphorylation promotes its binding to p120RasGAP (p120). Here, we elucidate the mechanism by which p120 binding regulate

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Schimmel, Lilian, and Emma Gordon. "The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall." Biochemical Society Transactions 46, no. 6 (2018): 1673–80. http://dx.doi.org/10.1042/bst20180377.

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Endothelial cell–cell adhesion within the wall of the vasculature controls a range of physiological processes, such as growth, integrity and barrier function. The adhesive properties of endothelial cells are tightly controlled by a complex cascade of signals transmitted from the surrounding environment or from within the cells themselves, with the dynamic nature of cellular adhesion and the regulating signalling networks now beginning to be appreciated. Here, we summarise the current knowledge of the mechanisms controlling endothelial cell–cell adhesion in the developing and mature blood vascu

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Zhang, Jin, He Liu, Huan Xu та ін. "Molecular weight-modulated electrospun poly(ε-caprolactone) membranes for postoperative adhesion prevention". RSC Adv. 4, № 79 (2014): 41696–704. http://dx.doi.org/10.1039/c4ra07216b.

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Electrospun PCL membranes with various molecular weights behave distinctively for the prevention of surgery induced-adhesions, which finally helped acquire well-suited candidates for anti-adhesion biomaterial films.

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Garrod, David, and Tomomi E. Kimura. "Hyper-adhesion: a new concept in cell–cell adhesion." Biochemical Society Transactions 36, no. 2 (2008): 195–201. http://dx.doi.org/10.1042/bst0360195.

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We have developed a new concept of cell–cell adhesion termed ‘hyper-adhesion’, the very strong adhesion adopted by desmosomes. This uniquely desmosomal property accounts for their ability to provide the intercellular links in the desmosome–intermediate filament complex. These links are targeted by diseases, resulting in disruption of the complex with severe consequences. Hyper-adhesion is characteristic of desmosomes in tissues and is believed to result from a highly ordered arrangement of the extracellular domains of the desmosomal cadherins that locks their binding interaction so that it is

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Lipke, Peter N., Jason M. Rauceo, and Albertus Viljoen. "Cell–Cell Mating Interactions: Overview and Potential of Single-Cell Force Spectroscopy." International Journal of Molecular Sciences 23, no. 3 (2022): 1110. http://dx.doi.org/10.3390/ijms23031110.

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It is an understatement that mating and DNA transfer are key events for living organisms. Among the traits needed to facilitate mating, cell adhesion between gametes is a universal requirement. Thus, there should be specific properties for the adhesion proteins involved in mating. Biochemical and biophysical studies have revealed structural information about mating adhesins, as well as their specificities and affinities, leading to some ideas about these specialized adhesion proteins. Recently, single-cell force spectroscopy (SCFS) has added important findings. In SCFS, mating cells are brough

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TANAKA, Keiji. "Molecular Picture of Adhesive Interface." Journal of The Adhesion Society of Japan 56, no. 2 (2020): 42–47. http://dx.doi.org/10.11618/adhesion.56.42.

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AMAMOTO, Yoshifumi, and Yuichi MASUBUCHI. "Molecular Simulation on Polymer Adhesives." Journal of The Adhesion Society of Japan 53, no. 1 (2017): 19–23. http://dx.doi.org/10.11618/adhesion.53.19.

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Cooley, Marion A., Jill M. Broome, Christoph Ohngemach, Lewis H. Romer, and Michael D. Schaller. "Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase." Molecular Biology of the Cell 11, no. 9 (2000): 3247–63. http://dx.doi.org/10.1091/mbc.11.9.3247.

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The carboxy-terminal 150 residues of the focal adhesion kinase (FAK) comprise the focal adhesion-targeting sequence, which is responsible for its subcellular localization. The mechanism of focal adhesion targeting has not been fully elucidated. We describe a mutational analysis of the focal adhesion-targeting sequence of FAK to further examine the mechanism of focal adhesion targeting and explore additional functions encoded by the carboxy-terminus of FAK. The results demonstrate that paxillin binding is dispensable for focal adhesion targeting of FAK. Cell adhesion-dependent tyrosine phosphor

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Katz, Ben-Zion, Eli Zamir, Alexander Bershadsky, Zvi Kam, Kenneth M. Yamada, and Benjamin Geiger. "Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions." Molecular Biology of the Cell 11, no. 3 (2000): 1047–60. http://dx.doi.org/10.1091/mbc.11.3.1047.

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This study establishes that the physical state of the extracellular matrix can regulate integrin-mediated cytoskeletal assembly and tyrosine phosphorylation to generate two distinct types of cell-matrix adhesions. In primary fibroblasts, α5β1 integrin associates mainly with fibronectin fibrils and forms adhesions structurally distinct from focal contacts, independent of actomyosin-mediated cell contractility. These “fibrillar adhesions” are enriched in tensin, but contain low levels of the typical focal contact components paxillin, vinculin, and tyrosine-phosphorylated proteins. However, when

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AlMotasem, Ahmed Tamer. "Influence of Alloying Additives on The Adhesive Properties of Steels: Atomic Level Simulation." JOURNAL OF ADVANCES IN PHYSICS 14, no. 3 (2018): 5734–40. http://dx.doi.org/10.24297/jap.v14i3.7601.

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In the present work we report atomistic molecular dynamics simulation results on adhesion force between self-mated iron/iron, iron/vanadium, iron-cementite and iron/titanium surfaces has been determined and we found that iron/cementite surface exhibits lower adhesive force than that of iron/iron surface. The results showed that adhesion, quantified by the work of adhesion, decreased as the vanadium content increased and highest reduction was obtained for 10 at.% vanadium and 7.5 at.% for titanium. Furthermore, the variation of adhesion force with temperature was studied in the temperature rang

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Takahashi, Kunio. "Manipulation Mechanisms for Micro-Assembly Technology." Materials Science Forum 502 (December 2005): 327–34. http://dx.doi.org/10.4028/www.scientific.net/msf.502.327.

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Author has been working about mechanisms of some manipulation methods for micro-assembly, i.e., a mechanical method, an electro-adhesive method, and a capillary method. For the purpose of optimization and breakthrough of the micro-assembly technology, theoretical understanding of adhesion phenomenon is essential, because the adhesional force is proportional to the size of objects meanwhile gravitational force is proportional to the third power of it. Consequently the adhesion phenomenon is no more negligible for the smaller objects usually less than 1 mm, e.g., micro-objects. Author will intro

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