Gotowa bibliografia na temat „Migraine research”

Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that have started to revolutionize medical science in terms of understanding disease, testing pharmacologically active compounds, and offering novel ways to treat disease. Organoids of the liver, kidney, intestine, lung, and brain have been developed in recent years. Human brain organoids are used for understanding pathogenesis and investigating therapeutic options for neurodevelopmental, neuropsychiatric, neurodegenerative, and neurological disorders. Theoretically, several brain disorders can be modeled with the aid of human brain organoids, and hence the potential exists for understanding migraine pathogenesis and its treatment with the aid of brain organoids. Migraine is considered a brain disorder with neurological and non-neurological abnormalities and symptoms. Both genetic and environmental factors play essential roles in migraine pathogenesis and its clinical manifestations. Several types of migraines are classified, for example, migraines with and without aura, and human brain organoids can be developed from patients with these types of migraines to study genetic factors (e.g., channelopathy in calcium channels) and environmental stressors (e.g., chemical and mechanical). In these models, drug candidates for therapeutic purposes can also be tested. Here, the potential and limitations of human brain organoids for studying migraine pathogenesis and its treatment are communicated to generate motivation and stimulate curiosity for further research. This must, however, be considered alongside the complexity of the concept of brain organoids and the neuroethical aspects of the topic. Interested researchers are invited to join the network for protocol development and testing the hypothesis presented here.

ABSTRACT Stress is a general pattern of reactions and adaptations, in the sense that the pattern of reactions to stressors, which can come from within or outside the individual concerned, can be real or not. Headaches called migraines are headaches with pain attacks lasting 4 – 72 hours. Pain is usually unilateral, throbbing, moderate to severe pain intensity and exacerbated by activity, and may be accompanied by nausea and vomiting, photophobia and phonophobia. Complaints that are quite frequent and disturbing from among these complaints are migraine complaints. Migraines can interfere with academic achievement and can limit student activities. To be able to determine the relationship between stress and migraine incidence in students of the Faculty of Medicine, Malahayati University during the Covid-19 pandemic. This type of research uses analytical research methods, namely research conducted to examine the relationship between 2 or more variables as many as 60 samples of students from the Faculty of Medicine, Malahayati University during the Covid-19 pandemic. that meet the inclusion criteria. Data collection began in September 2020. By using a questionnaire as the main measuring tool to collect data. The data were evaluated by Spearman's test. In this study, The research sample was 60 students, indicating that most of the respondents had normal stress levels (50.6%), and showed that most of the respondents had migraine levels (51.9%). The results of the Spearman correlation obtained p value = 0.000 and r = 0.746 because p = 0.000 <0.05. This study, there is a significant correlation between Stress and Migraine Incidence in Students of the Faculty of Medicine, Malahayati University during the Covid-19 pandemic. Keywords: Stress, Migraine, Covid-19 ABSTRAK Stres merupakan pola reaksi serta adaptasi umum, dalam arti pola reaksi menghadapi stresor, yang dapat berasal dari dalam maupun luar individu yang bersangkutan, dapat nyata maupun tidak nyata sifatnya. Nyeri kepala yang disebut migrain adalah nyeri kepala dengan serangan nyeri yang berlangsung 4 – 72 jam. Nyeri biasanya unilateral, sifatnya berdenyut, intensitas nyerinya sedang sampai berat dan diperhebat oleh aktivitas, dan dapat disertai mual muntah, fotofobia dan fonofobia. Keluhan yang cukup sering terjadi dan mengganggu dari antara keluhan tersebut adalah keluhan migrain. Migrain dapat menganggu prestasi akademik dan dapat membatasi kegiatan mahasiswa. Untuk dapat mengetahui Hubungan Stres dengan Kejadian Migrain pada Mahasiswa/i Fakultas Kedokteran Universitas Malahayati disaat pandemi Covid-19. Jenis Penelitian ini menggunakan metode penelitian analitik yaitu penelitian yang dilakukan untuk menguji hubungan 2 variabel atau lebih sebanyak 60 sampel Mahasiswa/i Fakultas Kedokteran Universitas Malahayati disaat pandemi Covid-19. yang memenuhi kriteria inkulsi. Pengambilan data dimulai pada bulan September 2020. Dengan menggunakan kuisioner sebagai alat ukur utama untuk mengumpulkan data. Data dievaluasi dengan uji Spearman. Didapatkan sampel penelitian berjumlah 60 Mahasiswa/i menunjukkan bahwa sebagian besar responden memiliki tingkat stres normal (50,6%), dan menunjukkan bahwa sebagian besar responden memiliki tingkat migrain (51,9%). Hasil korelasi Spearman didapatkan nilai p=0.000 dan nilai r=0.746 karena nilai p=0.000 <0.05. Terdapat korelasi yang bermakna antara Stres dengan Kejadian Migrain pada Mahasiswa/i Fakultas Kedokteran Universitas Malahayati disaat pandemi Covid-19. Kata Kunci: Stress, Migrain, Covid-19

ABSTRACT Stress is a general pattern of reactions and adaptations, in the sense that the pattern of reactions to stressors, which can come from within or outside the individual concerned, can be real or not. Headaches called migraines are headaches with pain attacks lasting 4 – 72 hours. Pain is usually unilateral, throbbing, moderate to severe pain intensity and exacerbated by activity, and may be accompanied by nausea and vomiting, photophobia and phonophobia. Complaints that are quite frequent and disturbing from among these complaints are migraine complaints. Migraines can interfere with academic achievement and can limit student activities. To be able to determine the relationship between stress and migraine incidence in students of the Faculty of Medicine, Malahayati University during the Covid-19 pandemic. This type of research uses analytical research methods, namely research conducted to examine the relationship between 2 or more variables as many as 60 samples of students from the Faculty of Medicine, Malahayati University during the Covid-19 pandemic. that meet the inclusion criteria. Data collection began in September 2020. By using a questionnaire as the main measuring tool to collect data. The data were evaluated by Spearman's test. In this study, The research sample was 60 students, indicating that most of the respondents had normal stress levels (50.6%), and showed that most of the respondents had migraine levels (51.9%). The results of the Spearman correlation obtained p value = 0.000 and r = 0.746 because p = 0.000 <0.05. This study, there is a significant correlation between Stress and Migraine Incidence in Students of the Faculty of Medicine, Malahayati University during the Covid-19 pandemic. Keywords: Stress, Migraine, Covid-19 ABSTRAK Stres merupakan pola reaksi serta adaptasi umum, dalam arti pola reaksi menghadapi stresor, yang dapat berasal dari dalam maupun luar individu yang bersangkutan, dapat nyata maupun tidak nyata sifatnya. Nyeri kepala yang disebut migrain adalah nyeri kepala dengan serangan nyeri yang berlangsung 4 – 72 jam. Nyeri biasanya unilateral, sifatnya berdenyut, intensitas nyerinya sedang sampai berat dan diperhebat oleh aktivitas, dan dapat disertai mual muntah, fotofobia dan fonofobia. Keluhan yang cukup sering terjadi dan mengganggu dari antara keluhan tersebut adalah keluhan migrain. Migrain dapat menganggu prestasi akademik dan dapat membatasi kegiatan mahasiswa. Untuk dapat mengetahui Hubungan Stres dengan Kejadian Migrain pada Mahasiswa/i Fakultas Kedokteran Universitas Malahayati disaat pandemi Covid-19. Jenis Penelitian ini menggunakan metode penelitian analitik yaitu penelitian yang dilakukan untuk menguji hubungan 2 variabel atau lebih sebanyak 60 sampel Mahasiswa/i Fakultas Kedokteran Universitas Malahayati disaat pandemi Covid-19. yang memenuhi kriteria inkulsi. Pengambilan data dimulai pada bulan September 2020. Dengan menggunakan kuisioner sebagai alat ukur utama untuk mengumpulkan data. Data dievaluasi dengan uji Spearman. Didapatkan sampel penelitian berjumlah 60 Mahasiswa/i menunjukkan bahwa sebagian besar responden memiliki tingkat stres normal (50,6%), dan menunjukkan bahwa sebagian besar responden memiliki tingkat migrain (51,9%). Hasil korelasi Spearman didapatkan nilai p=0.000 dan nilai r=0.746 karena nilai p=0.000 <0.05. Terdapat korelasi yang bermakna antara Stres dengan Kejadian Migrain pada Mahasiswa/i Fakultas Kedokteran Universitas Malahayati disaat pandemi Covid-19. Kata Kunci: Stress, Migrain, Covid-19

Riboflavin, a water-soluble member of the B-vitamin family, plays a vital role in producing energy in mitochondria and reducing inflammation and oxidative stress. Migraine pathogenesis includes neuroinflammation, oxidative stress, and mitochondrial dysfunction. Therefore, riboflavin is increasingly being recognized for its preventive effects on migraines. However, there is no concrete evidence supporting its use because the link between riboflavin and migraines and the underlying mechanisms remains obscure. This review explored the current experimental and clinical evidence of conditions involved in migraine pathogenesis and discussed the role of riboflavin in inhibiting these conditions. Experimental research has demonstrated elevated levels of various oxidative stress markers and pro-inflammatory cytokines in migraines, and riboflavin’s role in reducing these marker levels. Furthermore, clinical research in migraineurs showed increased marker levels and observed riboflavin’s effectiveness in reducing migraines. These findings suggest that inflammation and oxidative stress are associated with migraine pathogenesis, and riboflavin may have neuroprotective effects through its clinically useful anti-inflammatory and anti-oxidative stress properties. Riboflavin’s safety and efficacy suggests its usefulness in migraine prophylaxis; however, insufficient evidence necessitates further study.

Background:The prevalence of migraine headache varies somewhat across geographic regions. The last Canadian population-based study of migraine was in 1994. We report the findings of the Canadian Women and Migraine Survey. In addition to reporting migraine prevalence in Canadian women, the survey identified current consultation and treatment practices of women with migraine, and the psychological burden of migraine.Methods:The survey was conducted with a population-based sample of 1210 women using standard telephone research methods. Headache diagnoses were based on the International Headache Society (IHS) Classification.Results:Calculated prevalence of migraine headache was 26%. Only 51% of women with migraine had consulted a physician about their headaches. Women with migraines rely on over-the-counter medications and non-specific prescription medications. Less than 10% of women with migraine use triptans/dihydroergotamine for primary treatment. Ninety seven percent of women with migraine reported at least one psychosocial impact resulting from migraines.Conclusions:The prevalence of migraine in Canadian women appears static, and is again shown to be slightly higher than that reported in the United States. As in other epidemiologic studies, many women with migraine do not seek medical help for their headaches and perhaps as a result, few are using migraine-specific medications to treat their headaches. The impact of migraine on Canadian women is substantial with almost all women with migraine reporting adverse psychosocial effects of migraines on their lives.

Abstract: Migraine is one of the primary headaches that often causes moderate to severe disability. One of the most commonly consumed psychoactive substances associated with migraine is caffeine. This study was aimed to evaluate the relationship between migraine and caffeine thoroughly based on various studies. This was a literature review study using databases of Pubmed/Medline, Cochrane, Wiley Online Library, Science Direct, Google Scholar, and Garuda. The eligibility criteria for this study were observational research articles or clinical trials, written in Indonesian or English, published in the last five years, and their fulltexts could be accessed. The results obtained 10 articles. Almost all of them showed that caffeine could cause migraine whether after caffeine consumption (non-absent group) or no consumption of caffeine (absent group). The association of caffeine with migraine was more significant than with tension headaches. Besides being a trigger factor of migraine, caffeine cpuld also act as a migraine therapy. In conclusion, there is a close association between migraine and caffeine. Migraine tends to be triggered than to be reduced by caffeine.Keywords: caffeine, migraine Abstrak: Migrain merupakan salah satu jenis nyeri kepala primer yang sering menyebabkan disabilitas sedang dan berat. Salah satu zat psikoaktif yang umum dikonsumsi dan berhubungan dengan migrain yaitu kafein. Penelitian ini bertujuan untuk menelaah hubungan migrain dan kafein lebih mendalam berdasarkan berbagai penelitian. Jenis penelitian ialah literature review menggunakan database dari Pubmed/Medline, Cochrane, Wiley Online Library, Science Direct, Google Scholar, dan Garuda. Kriteria kelayakan artikel penelitian ialah artikel penelitian observasional atau uji klinis, ditulis dalam Bahasa Indonesia atau Inggris, terbit dalam lima tahun terakhir, dan naskah lengkap artikel dapat diakses secara lengkap. Hasil penelitian mendapatkan 10 artikel penelitian. Hampir semua penelitian memperlihatkan bahwa kafein dapat menyebabkan migrain baik setelah kafein dikonsumsi (kelompok nonabsen) maupun saat kafein sudah tidak dikonsumsi (kelompok absen). Hubungan kafein dengan migrain lebih kuat dibandingkan dengan nyeri kepala tipe tegang. Selain menjadi factor pencetus, kafein juga dapat berperan sebagai terapi migrain. Simpulan penelitian ini ialah terdapat hubungan erat antara migrain dan kafein. Migrain cenderung lebih sering dicetuskan oleh kafein dibandingkan diringankan oleh kafein.Kata kunci: kafein, migrain

The most common neurologic disorder is migraines. Migraine is defined as throbbing headaches that can be associated with auras. The headaches are episodic and can be debilitating in quality. Migraines can be triggered by emotional stress, lack of sleep, bright lights, loud noise, certain foods, and other environmental factors. The most effective way of preventing migraines is to avoid these triggers. A migraine can begin with prodromes or warning signs such as loss of vision, loss of motor reflexes or sensation. In this review, the types of migraine, signs and symptoms, pathways leading up to auras, and detailed pathophysiology will be discussed. The pathophysiology of a migraine consists of three different mechanisms: 1) cortical spreading depression, 2) the trigemino vascular system, and 3) sensitization. Three different treatment methods for a migraine will be discussed: 1) pharmacological, 2) non-pharmacological and 3) lifestyle modifications. Lifestyle modifications include eating a healthy diet, exercising, and maintaining proper sleep hygiene. Pharmacological treatments can be preventative or abortive. The latest migraine treatment of calcitonin gene-related peptide (CGRP) antagonist use will be discussed in this review and compared to other treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, and Triptans. Future research methods to prevent and better treat migraine headaches are considered a hot topic in medicine and these novel methods will be discussed.

Migraine is a common, debilitating neurovascular disease charactensed by severe recurrent headache, nausea and vomiting, photophobia and phonophobia. It is clinically diagnosed based on criteria specified by the International Headache Society (IHS), defining two major classes of migraine: migraine with aura (MA) and migraine without aura (MO) MA sufferers experience neurovascular disturbances that precede the headache phase of an attack. Although migraine is partly influenced by environmental determinants, there is a significant genetic component, with disease heritability estimated to be up to 60% and mode of transmission multifactorial. The disorder is common with a large Dutch study reporting lifetime prevalence estimates of 33% in women and 13.3% in men, with an earlier study estimating 24% of women and 12% of men in the overall population. Mutations in various ion channel genes are responsible for neuromuscular and other neurological disorders. Inherited ion channel mutations or 'channelopathies' are increasingly found to be the cause of various neurological disorders in humans. In familial hemiplegic migraine (FHM), a rare subtype of migraine with aura, mutations in the CACNA1A gene (localised at C19p13) have been fbund (FHM1). This gene codes for the alphalA subunit of the neuronal voltage-dependent P/Q-type calcium channel. Recently a second gene, ATP1A2 (FHM2) (localised at C1q23), was implicated in some EHM families. The ATP1A2 ion channel gene, codes for the alpha2 subunit of the Na+, K+ ion ATPase pump. These findings of mutations in these genes have focused attention on central nervous system ionic channels and helped to better understand EHM pathophysiology, where the best genetic evidence providing molecular insight into migraine still comes flom the mutations detected in the rare form of migraine with aura; FHM. Migraine family studies, at the Genomic Research Centre (GRC), have utilised linkage analysis methods in providing results that have indicated suggestive linkage to the FHM1-CACNA1A region on l9p13, in a large multigenerational family (Migraine Family 1; MEl) affected with typical migraine. Also linkage studies conducted within the GRC have implicated an additional susceptibility region on chromosome 1q31, but still not ruling out a second susceptibility region on C1q23, with the possibility of there being two distinct loci, on the chromosome lq region. The focus of research in this thesis is on two main chromosomal regions, which were tested for migraine susceptibility on chromosome 1 and chromosome 19. The research involved a cross-disciplinary approach utilising association, linkage and mutation screening approaches. Allelic candidate gene studies can provide a suitable method for locating genes of small effect that contribute to complex genetic disorders, such as migraine. Family linkage studies are useful for detection of chromosomal susceptibility regions and association studies are powerful when a plausible candidate gene and a sequence variant with potential functional relevance is examined. Mutation screening studies can indicate a direct cause of disorders such as migraine, where possible sequence variants may alter the translation of proteins in genes, causing the disease. The first gene exanted on chromosome 19 was that of the Low Density Lipoprotein Receptor (LDLR) gene. The LDLR gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome l9pl3.2 performing an association analysis in 244 typical migraine affected patients, 151 suffering from migraine with aura, 96 with migraine without aura and 244 unaffected controls. The populations consisted of Caucasians only and controls were age and sex matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after separation of the migraine affected individuals into subgroups of MA and MO affected patients. This is in contradiction to Mochi et al, 2003 who found a positive association of this variant with MO. Our study discusses possible differences between the two studies and extends this research by investigating circulating cholesterol levels in a migraine affected genetically-isolated population. Another gene examined on chromosome l9pl3 was the insulin receptor gene (1NSR). The aim of this study was to investigate through direct sequencing the INSR gene in DNA samples from a migraine affected family previously showing linkage to chromosome l9pl3 in an attempt to detect disease associated mutations. The insulin receptor gene (INSR) on chromosome 19pl3.3-13.2 is a gene of interest since a number of SNPs located within the gene have been implicated in migraine with (MA) and without aura (MO). Six DNA samples obtained from non-founding migraine affected members of migraine family one (MF 1) were used in this study. Genomic DNA was sequenced for the 1NSR gene in exons 1-22 and the promoter region. In the six migraine family member samples, previously reported single nucleotide polymorphisms (SNP5) were detected within two exonic DNA coding regions of the INSR gene. These SNPs, in exon 13 and 17, do not alter the normal INSR polypeptide sequence. In addition, intron 7 also revealed a DNA base sequence variation. For the 5' untranslated promoter region of the gene, no mutations were detected. In conclusion, this study detected no INSR mutations in affected members of a chromosome 19 linked migraine pedigree. Hence, migraine linkage to this chromosomal region may involve other candidate genes. The NOTCH3 gene on C19p13.2-p13.l has previously been shown to be a gene involved in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and may also be implicated in migraine as there are some symptom similarities between the two disorders. The TNFSF7 gene localised on Cl9pl3 is homologous to the ligands of the TNF receptor family, including TNF-alpha and TNF-beta, genes that have both been previously associated with migraine. This study investigated the migraine susceptibility locus at Cl9p13 studying two genes that may be involved in the disorder. The NOTCH3 gene was analysed by sequencing all exons with known CADASIL mutations in a family (MF1) that has previously been shown to be linked to Cl9pl3. The sequencing results for affected members of this pedigree proved to be negative for all known sequence variants giving rise to mutation causing amino acid changes for CADASIL. The direct sequencing results displayed that of a normal coding sequence for the NOTCH3 gene F or the TNFSF7 gene, this was investigated through SNP association analysis using a matched case-control migraine diagnosed population. Chi-square results showed non-significant P values across all populations tested against controls except for the MO subgroup which displayed a weak association with the TNFSF7 SNP (genotype, allele analysis P = 0.036, P = 0 017 respectively). Our results suggest that common migraine is not caused by any known CADASIL mutations in the NOTCH3 gene of interest however, the TNFSF7 gene displayed signs of involvement in a MO affected population, but, further studies are needed to confirm these results and to further explore a TNF receptor - migraine potential interaction. A final examination on chromosome 19 involved a case report of an extremely rare and severe form of migraine. As stated earlier Familial Hemiplegic Migraine (FHM) is a severe rare sub-type of migraine and gene mutations on chromosome 19 have been identified in the calcium channel gene CACNA1A (Cl9pl3) fOr FHM. Recently a gene mutation (S218L) for a dramatic syndrome originating from FHM, commonly named 'migraine coma', has implicated exon 5 of the CACNA1A gene. The occurrence of trivial head trauma, in FHM patients, may also be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval. Hemiplegic migraine has also been found to be sporadic in which both forms share a similar spectrum of clinical presentations and genetic heterogeneity. The case report presented in this study enhances the involvement of the S218L CACNA1A mutation in the extremely rare disorder of minor head trauma induced migraine coma. It not only proves to be a powerful diagnostic tool in detecting cases of FHM head trauma induced coma but also for sporadic hemiplegic migraine (SHM) coma subjects. We conclude from this case study that the S218L mutation, in the CACNA1A calcium channel subunit gene, is involved in sporadic hemiplegic migraine (SHM), delayed cerebral edema and coma after minor head trauma. This thesis also involved analysis of chromosome 1 for migraine susceptibility, where FHM studies provided a foundation fOr common migraine research on chromosome 1. Studies have suggested that mutations in the CACNA1A gene on chromosome l9p cause FHM in only approximately 50% of affected pedigrees. The CACNAIA gene has previously been tested, within the Genomics Research Centre, in the common forms of migraine; however no new mutations or the FHM mutations were detected in these MA/MO affected samples. A second FHM susceptibility locus maps to chromosome 1q23 and mutations in the ATP1A2 gene have recently been implicated in two Cl-linked FHM pedigrees. As FHM is considered a rare and severe form of MA, it is possible that the chromosome 1q23 locus, and the ATP1A2 gene, may be involved in the common forms of migraine with (MA) and possibly without aura (MO). Also, we have previously reported evidence of linkage to microsatellite markers on chromosome 1q31 in a large pedigree affected predominately with MA, which suggests the possibility that there are two distinct loci for migraine susceptibility on chromosome 1. The objectives of this study were to extend our linkage analysis of chromosome lq microsatellite markers in predominantly migraine with aura pedigrees. Also, our aim was to test the novel FHM-2 ATP1A2 gene for involvement in these migraine affected pedigrees and a previous pedigree (Migraine Family 14; MF 14) showing evidence of linkage of markers to Clq31. This was performed by a chromosome 1 scan (31 markers) in 21 multiplex pedigrees affected mainly with MA. Also, the known FHM-2 ATP1A2 gene mutations were tested, by sequencing, fOr involvement in MA and MO in these pedigrees. Mutation screening by direct sequencing was also performed throughout the coding areas of the ATP1A2 gene in 3 MA individuals fiom MF14. The results of this study detected evidence for linkage in our migraine pedigrees at chromosome 1q23, to microsatellite markers spanning the ATP1A2 (FHM-2) gene. However testing of the known ATP1A2 gene mutations (for FHM) in migraine probands of pedigrees showing excess allele sharing was negative, with no mutations detected in these migraineurs. Sequencing of the entire coding areas of the gene through 3 MA affecteds from MF14, a pedigree showing significant linkage to this region, was also negative for mutations. In conclusion, this study reported that microsatellite markers on chromosome 1q23 show evidence of excess allele sharing in MA and some MO pedigrees, suggesting linkage to the common forms of migraine and the presence of a susceptibility gene in this region. The new FHM-2 (ATPIA2 gene) mutations reported by Fusco et al, 2003 do not cause migraine in probands of affected pedigrees showing excess allele sharing to markers in this genomic region. Also no mutations were detected in all exons of the ATP1A2 gene in 3 MA affected individuals from a large pedigree (MF14) showing linkage to this region. Investigation in this thesis continued on chromosome 1, with other genes being examined on C1q23, as well as the C1q31 region for a migraine susceptibility locus or gene. Previously in our laboratory, evidence for linkage was shown to migraine at C1q31 in one family predominantly affected with MA, with microsatellite markers in this region. The initial Cl study (above; ATP1A2 gene) has also provided evidence for linkage to the chromosome 1 locus 1q23, with evidence for excess allele sharing of markers in predominantly MA affected pedigrees. To further investigate both chromosome I loci, an investigation with six candidate genes that lie within the C1q23 and 1q31 regions through association analysis was undertaken. The results from this study reported non-significant chi-square results, showing P values greater than 0.05 across all SNPs (and a CA rpt) tested. An exception was the rs704326 SNP from exon 43 of the CACNA1E gene on C1q31. P values significantly less than 0.001 were obtained in the total migraine population and the MA subgroup, with similar frequency comparisons ascertained in both genotype and allele analysis. Examination through contingency table analysis of the CACNA1E flequency data indicated that the risk allele (A) was over-represented in the migraine group compared to the control group. Further comparison of the genotype data indicated a difference in frequency distributions (P less than 0 0001). Stratified analyses of migraine subtypes indicated that this association was specifically attributed to the MA subtype group. Odds ratios produced an OR of 4.14 with a 95% CI of 2.36 - 7.26 (P less than 0.0001). The positive association results obtained within the CACNA1E gene are interesting in the fact that FHM is considered to be a rare and severe form of migraine with aura (MA) and FHM-1 is caused by mutations contained within the calcium channel gene CACNA1A (localized at Cl9p13). The idea that FHM and specifically an FHM gene in the C1q31 genomic region may also contribute to susceptibility to the more common forms of migraine i e. migraine with aura, strongly supports and reinforces the idea that a common defective gene may be influencing both FHM and typical migraine. In conclusion, this thesis undertook a cross-disciplinary approach to genetic research of a complex disorder. The research involved linkage, association and mutation analysis strategies of migraine. This research implicated a specific variant on chromosome 1 and further supported the heterogeneic nature of migraine. Future directions into migraine research should involve further investigation of this specific variant and this genomic region. Such studies may aid in the development of more precise diagnosis and treatment methods for this complex disorder.

Migraine is a common, debilitating neurovascular disease charactensed by severe recurrent headache, nausea and vomiting, photophobia and phonophobia. It is clinically diagnosed based on criteria specified by the International Headache Society (IHS), defining two major classes of migraine: migraine with aura (MA) and migraine without aura (MO) MA sufferers experience neurovascular disturbances that precede the headache phase of an attack. Although migraine is partly influenced by environmental determinants, there is a significant genetic component, with disease heritability estimated to be up to 60% and mode of transmission multifactorial. The disorder is common with a large Dutch study reporting lifetime prevalence estimates of 33% in women and 13.3% in men, with an earlier study estimating 24% of women and 12% of men in the overall population. Mutations in various ion channel genes are responsible for neuromuscular and other neurological disorders. Inherited ion channel mutations or 'channelopathies' are increasingly found to be the cause of various neurological disorders in humans. In familial hemiplegic migraine (FHM), a rare subtype of migraine with aura, mutations in the CACNA1A gene (localised at C19p13) have been fbund (FHM1). This gene codes for the alphalA subunit of the neuronal voltage-dependent P/Q-type calcium channel. Recently a second gene, ATP1A2 (FHM2) (localised at C1q23), was implicated in some EHM families. The ATP1A2 ion channel gene, codes for the alpha2 subunit of the Na+, K+ ion ATPase pump. These findings of mutations in these genes have focused attention on central nervous system ionic channels and helped to better understand EHM pathophysiology, where the best genetic evidence providing molecular insight into migraine still comes flom the mutations detected in the rare form of migraine with aura; FHM. Migraine family studies, at the Genomic Research Centre (GRC), have utilised linkage analysis methods in providing results that have indicated suggestive linkage to the FHM1-CACNA1A region on l9p13, in a large multigenerational family (Migraine Family 1; MEl) affected with typical migraine. Also linkage studies conducted within the GRC have implicated an additional susceptibility region on chromosome 1q31, but still not ruling out a second susceptibility region on C1q23, with the possibility of there being two distinct loci, on the chromosome lq region. The focus of research in this thesis is on two main chromosomal regions, which were tested for migraine susceptibility on chromosome 1 and chromosome 19. The research involved a cross-disciplinary approach utilising association, linkage and mutation screening approaches. This research implicated a specific variant on chromosome 1 and further supported the heterogeneic nature of migraine. Future directions into migraine research should involve further investigation of this specific variant and this genomic region. Such studies may aid in the development of more precise diagnosis and treatment methods for this complex disorder.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
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Background: Migraine headache is a chronic pain condition that affects 20% of women of reproductive age, and is often treated with triptans. Triptans are serotonin 1B, 1D, and 1F receptor agonists that act as vasoconstrictors and inhibitors of the trigeminal cervical complex as well as peripheral neurons; they cross the blood brain barrier and placenta, and as such are plausible neurodevelopmental teratogens. No studies have examined risk of neurodevelopmental problems in children with prenatal triptan exposure. This dissertation had three aims: (1) to examine risk of behavioral problems in children using in the presence of time-varying confounding by concomitant medication use; (2) to examine risk of temperamental, motor, and communication disturbances associated with prenatal triptans exposure, adjusting for unmeasured confounding by migraine type and severity; and (3) to examine changes in neurodevelopment over time associated with prenatal triptan exposure. Methods: This dissertation used data from the Norwegian Mother and Child Cohort Study, a prospective birth cohort including more than 100,000 women recruited during their first prenatal ultrasound visit. Aims 1 and 3 used marginal structural models to assess the risk of (1) neurodevelopmental problems at age 36 months (Aim 1), or (2) change in risk of neurodevelopmental problems from 18 to 36 months (Aim 3) associated with prenatal triptan exposure. Aim 2 used propensity matching and calibration to adjust for unmeasured confounding by migraine type, severity, and attitudes towards medication use in pregnancy. Neurodevelopmental outcome measures included the Child Behavior Checklist (CBCL), the Emotionality, Activity, and Temperament Scale (EAS), and the Ages and Stages Questionnaire (ASQ). Exposure to triptans was ascertained by self-report. Results: Prenatal triptan exposure was associated with greater externalizing behavior problems at 18 and 36 months, as well as greater increases in emotionality and activity from 18 to 36 months. We observed no association between triptan exposure and motor skills or communication problems; triptan use during pregnancy was associated with migraine severity but not migraine type, and adjustment for unmeasured migraine characteristics moved effect estimates towards the null. Conclusions: Prenatal triptan exposure is associated with externalizing-type behaviors and temperament in children, while migraine itself is associated with internalizing-type behaviors and temperament. The use of concomitant medications and the severity of the underlying condition both exerted substantial influence on observed effect estimates, and should be considered in any future studies of triptan medication use in pregnancy.

My personal history and the stories of people with similar experiences have inspired my degree project. It revolves around the feeling of belonging when moving from one place to another, adapting to the new environment (e.g. culture, language, etc.), and yet staying in between. It's about the notion of home in the time of migration.  I want to capture the ideas of places and identity transformation through materiality. The tree is very human-like living material. I bend the wood, and, while doing so, it follows my moves and adapts to changed conditions. The tension and force create the shape, and the unfolded pieces become traces of my body movements.  I see the sculptures from the jeweler´s perspective, the performative and interactive pieces invite the viewer to participate.  In my smaller-scale series of work, I continue my materials research narrowing down my investigation from the body to my hands. The pandemic situation increases my awareness of touching and longing for real contact with people. I select a group of found and given to me objects which evoke memories of people and places I have been. By wrapping them into a metallic textile I create imprinted empty space. It becomes a container which questions what is left behind when someone is gone or something is taken away.  I place the handprints and the tree rings in parallel. Both are strong identification symbols. The wood rings mark the conditions in which. the tree grows, forming a unique sign language that visually explains the whole history of the tree.  Do people´s fingerprints change when they move from one place to another?

This report is the outcome of a Field Study project. The aim of the study was to findout how the floating deaf-mute children of migrant workers experience psychologicalproblems in Guiyang, China. Bronfenbrenner’s ecological system theory was used asa theoretical frame. Semi-structured interviews were carried out with 4 inner migrantcouples who have deaf-mute children receiving treatment in a Center for disabled inGuiyang. 12 professionals working with treating deaf-mute children are alsointerviewed as well as 5 deaf-mute children. In total together 21 informants areinterviewed. The result of this study shows that three main aspects influence thepsychological problems of floating deaf-mute children with migrant parents most:social welfare policy, family income conditions and the center of treatmentenvironment. This study explored the problems based on Brofenbreener’s ecologicalsystems approach, which for the author had a new perspective to research on thesituation of deaf-mute children of migrant workers in Guiyang, China.

There are over 3 million seasonal and migrant farmworkers in the U.S. agricultural industry with a significant percentage of farmworkers documented or native to the United States. Migrant farmworkers live below the federal poverty levels at high rates and experience low health care access and utilization. Guided by the fundamental cause theory, the purpose of this phenomenological study was to examine the lived experiences of migrant farmworkers and identify the factors impacting their health care access and utilization. Face-to-face interviews were conducted with 12 migrant farmworkers who had worked in Southwest Texas agricultural stream. Data were analyzed and coded to identify themes. Findings indicated that although lack of health insurance was a decisive factor in whether migrant farmworkers accessed or utilized health care services, distance to services, inflexible working hours, and cultural factors related to seeking care also influenced participants' lack of access to and utilization of health care services. Results may be used to aid local, state, and federal agencies in assisting migrant farmworkers in bridging the gap in health care and obtaining needed services.

The aim of this study is to find out the main psychological problems of inner migrants’ children in Guiyang and to give some suggestions to treat these problems. Compared to other social groups, inner migrants’ children meet specific psychological issue in migrate processing. It is a world-wide issue, especially in the developing countries today. In this research, both qualitative method and quantitative one are used. The research result shows that there are three aspects that influence the psychological condition of the inner migrants’ children most. They are social-economic condition of the family, school environment, and social policy.

AbstractScholars who write about migrant women, whether rural-urban or international migrants, have tended to always link women’s migration processes to men’s, thereby reducing women’s agency and will power. It is in this regard that women’s positionalities have continued to remain on the peripheries in literature (see Phillips & James, 2014), even if in reality they have become the main players in their own right. Kihato’s (2013) work reiterates the importance of the role of migrant women in shaping the way the city’s life is played out. Jayaram et al. (2019) posited that women are very mobile, frequently moving locally and internationally between their areas of origin and different urban work destinations. Xulu-Gama (2017), Kihato (2013) and Zulu (1993) prove that women do migrate on their own.

AbstractChapter 10.1007/978-3-030-91971-9_3 examined the gendered nature of a migrant division of labour. In this chapter we turn to family migration, traditionally associated with women as dependents and followers of men. The term is used to categorise the international movement of people who migrate due to new or established family ties. People moving for family reasons constitute the largest group of migrants entering OECD countries, ahead of labour and humanitarian migration (OECD, 2019). To move for family reasons may encompass an array of different kinds of migration trajectories, from the adoption of a foreign child to family members accompanying migrant workers or refugees, as well as people forming new family units with host country residents or family reunification (when family members reunite with those who migrated previously).

AbstractThis chapter addresses the question: whatformsof migration can be distinguished? This topic is closely tied to the issues addressed in the previous chapters, concerning why and how people migrate. Central to the discourse on migration forms—also called categories, types, or flows—lies another important question: whoaremigrants? This chapter dives into these questions. While the topic of migrant typologies itself would merit its own full-fledged analysis, this is beyond the scope of this chapter. The reflections herein rather seek to summarise some of the main arguments and questions pertaining to the debates on categorisation in migration studies.

AbstractDue to the conditions of apartheid and social engineering, internal labour migration played an important role in shaping the roles and relationships of South African families. In a recent study on internal labour migration in South Africa, Mokoene (2017) found that even though men remain the main migrants in households, young women are becoming prominent migrants as well. This finding echoes other existing findings on national and international migration which illustrate that women continue to migrate in large numbers within and across borders in search of employment (Xulu-Gama, 2017; Kihato, 2013; Walker, 1990). Studies also show that labour migration presents both benefits and costs for migrant sending families (Mokoene & Khunou, 2019; see also Yao & Treiman, 2011). In this chapter we take a closer look at experiences of the families of young women who migrate from the rural parts of Madibeng in the North West Province of South Africa, to neighboring cities in search of employment. This is from a study by Mokoene (2017) which found that the migration of these young women come with a cost including, non-remittance, parental absence, and poverty to the families left behind.

AbstractState policies may strongly influence the employment of migrants for care and domestic work (Ruhs & Anderson, 2010). Both sending and receiving countries have adopted mechanisms to channel migrants (especially women) into this specific occupation. The care market-oriented scenario described in the previous pages creates a growing demand for a (female) migrant labour force employed to work for longer hours and at lower wages than local workers (Anderson & Shutes, 2014; Cangiano & Shutes, 2010). These migrant care workers are generally disadvantaged by policies privileging skilled over unskilled migration, as well as by legislation denying (long-term) residence permits to people employed in the care sector. Policies that make the regular employment of migrants very difficult contribute to the under-valuation of these jobs, which are generally assigned to the most vulnerable and stigmatized subjects in each national context (Lan, 2006). Women migrating to work in the domestic and private care sector face a complex landscape of migration and labour regulations that is extremely difficult to navigate. The situation is also problematic for households that cannot find appropriate or affordable care within declining welfare states and among fellow nationals reluctant to take these jobs, but are forbidden or discouraged from directly hiring a domestic worker who is a third-country national. As a consequence, irregular migration and informal work are expanding within the realm of private homes.

AbstractFamily migration is the term used to categorise the international movement of people who migrate due to new or established family ties. People moving for family reasons constitute the largest group of migrants entering OECD countries, ahead of labour and humanitarian migration (OECD, 2017). The study of migrant families cuts across the available legal definitions of family and brings to light emerging forms of living together, gender roles, sexualities, kinship ties, and caregiving practices. This chapter selectively synthesises recent scholarship on family migration, providing insights on the institutionalisation of the field, outlining its approaches and methodologies, and highlighting emerging topics for future research. These include transnational families and how they stay in contact; separated families and deportation; the impact of family migration policies; marriage migration and multi-sited and longitudinal studies used in studying the transformation and diversification of family forms.

AbstractThis chapter focuses on the reception system for migrants, a system that consists of procedures that take place between practices of what is known as first reception and longer-term plans for integration. When we use the term migrant in this chapter, we are referring to those who migrate towards a territory, have arrived at a territory, or live in the territory in question for a short or long period of time. Unless noted otherwise, the term does not distinguish between migrants, asylum seekers and refugees. Our research is built on an analysis of two key periods that are critical in the emergence, evolution and consolidation of this intermediary space. Firstly, at the start of the 2000s, reception emerged as a concept and practice related to the governance of so-called transit migration. This period was characterised by a plethora of complex forced and voluntary mobilities inside Greece and the EU. Furthermore, during this period, the state of ‘being in limbo’ became established as a situation in between borders, as well as in between transiting (through) and settling (in) a territory. During the second key period from 2015 to 2019, we observe contradictory policy attempts to consolidate migrant reception as a formal system, including new infrastructures like camps and housing programmes, which were maintained by diverse agents and jurisdictions. The ‘hotspot’ approach, the closing down of the Balkan route and the EU-Turkey Statement constituted important impediments to the development of inclusive practices by international humanitarian agencies and grassroots solidarity initiatives.

AbstractSouth-to-South migration instead of South to the Global North will dominate global migration trends in the future. This calls for redefining how we view and theorise about migration to the Global South, who is migrating, to which countries, the reasons for migration, whether this is a renewed form of circular migration, our understanding of transnationalism, the role of remittances and how migrants are received in the countries of the South and. In particular, I argue that migration research to and from Africa is not given the prominence it deserves in the global migration literature. I further argue that that the similarities and differences of migration to the Global South is under-theorised. The increase in South-to-South migration is creating a shift in economies resulting in the creation of new ‘geographies of growth’ and thus a Sociology of Migration understanding of patterns of migration and development in the Global South is needed. A case study of South Asian migrants to South Africa is illustrative of these geographies of growth and shows how migrants develop instrumental and contingent solidarities to integrate.

Background: In 2018, calcitonin gene-related peptides (CGRP) were approved in the United States as the first class of specific migraine prevention drugs. Objectives: To analyze the efficacy and therapeutic safety of erenumab for preventing migraine. Methods: A narrative literature review was carried out by researching in the PubMed/MEDLINE and SciELO databases, using the descriptor “migraine disorders” and the keyword “erenumab” combined by the Boolean operator AND. Eight articles were selected, between 2017 and 2020. Results: The pathophysiology of migraine is related to CGRP through nociceptive modulation in the trigeminovascular system. Therefore, erenumab was developed, which is a human monoclonal antibody that binds selectively and potently to the canonical receptor of CGRP and acts as an antagonist of CGRP. Evidence indicates that the monthly dose of 70mg or 140mg reduces the frequency, quality and intensity of acute and chronic migraines. Studies report a decrease of two to six days of migraine using erenumab. The same adverse reactions occurred in both placebo and experimental groups, including upper respiratory tract viral infection, pain at the injection site and nausea. Conclusions: Erenumab is a promising drug, because it showed efficacy in the first days of treatment, absence of significant side effects and low rate of discontinuation. Aspects such as safety, effect durability, impact on quality of life and cost require further research.

Background: Migraine and anxiety are common neuro-psychiatric disorders in clinical practice, sharing symptoms and epidemiological factors among themselves. The presence of both pathologies in the same individual is frequently reported in the literature. Objectives: To report the clinical and epidemiological correlations established between generalized anxiety disorder and migraine. Methodology: Systematic review of studies published between 2016 and 2021, exploring the association between generalized anxiety disorders and Migraine. The descriptors “association”, “Migraines” and “Generalized Anxiety Disorder” were used in the LILACS, SCIELO and PUBMED databases. Fourteen articles were selected, mostly dealing with epidemiological studies. Results: Evidence suggests that these pathologies are associated and share common symptoms, pathophysiology and epidemiological factors. Studies corroborate that anxiety and painful sensation are more strongly associated with migraine than with other psychiatric illnesses. It has also demonstrated some characteristics of patients who are predisposed to develop both comorbidities such as smoke, low income and a history of other previous diseases. Common triggering factors such as pain, sleep disorders and stress can also contribute to the association between pathologies. Conclusions: Based on the studies analyzed in full, the high prevalence of both diseases in the same individual highlights the importance of research on the cause and consequence relationship between Anxiety and Migraine, since this is not yet clarified in the medical literature. In addition, paying attention to migraine correlation to generalized anxiety disorder increases the quality of life of the patient in the short and long term, as well as help in the choice of better treatments.

The advances in digital data collection and storage technology allows the storage of a huge amount of medical publications in MEDLINE. This database contains more than 25 million references to journal articles and abstracts in life sciences and biomedicine. This research work builds on Swanson use of mathematical association between A and C concepts/terms through a list of B concept/terms retrieved from large medical literature databases that contain either A&B or B&C terms links A to C. Swanson discovered evidence that fish oil (A) may cure vessel blood disorder (C) and that magnesium (A) may be effective against migraine headache (C), which were clinically proven two years later. We present a cooccurrence mining algorithm and an A&C pre-defined domain Knowledge Base (containing for instance Garlic Composition and Blood pressure causes) to filter and reduce the exponential number of shared B terms retrieved from MEDLINE articles using Swanson’s Arrowsmith machine. The reduced number of relevant B terms makes it easier to build scientific evidence to validate publicly known remedies for recurrent diseases for instance establishing whether an important association exists between garlic and its impact on blood pressure.

Introduction: The increased use of devices during the SARS-CoV-2 pandemic is noteworthy. The democratization of technological products caused a significant increase an its use by the population across the globe. This has caused a consistent increase in the appearance of some diseases among users of those devices. Thus, a concern arises about the student context and its high workload online during the pandemic. Objective: Analyze the association between the use of digital devices and the incidence of headache among students during the pandemic. Design and setting: A literature review was conducted on the topic. Methods: We included 15 original articles in English and Portuguese from MEDLINE, Pubmed, and Google Academic databases, selected from 2011 to 2021. Results: In cross-sectional studies, reports of headache were higher in individuals who use digital devices frequently compared to those who do not use them, and migraine attacks with aura and use of analgesics were more recurrent in the first group. Several causal mechanisms between headache and the use of digital devices have already been proposed, such as exposure to electromagnetic fields, neck posture, stress and sleep alterations without, however, having any evidence. Conclusion: We conclude that the excessive use of electronic devices can increase the incidence and duration of headache. However, the literature on the subject is still limited. Therefore, there is an urgent need for research that controls exposure to digital devices in order to analyze the causal relationship between electronic devices and headache.

Due to improper Municipal Solid Waste Management (MSWM), waste has become one of the pollution sources and caused diverse environmental impacts as well as negative impacts on human health and safety. Despite adverse health impacts on many living organisms, MSW handlers are also subjected to Occupational Health and Safety (OHS) issues in Sri Lanka. Although, they play a significant role in MSWM, the OHS of MSW handlers has been neglected in Sri Lanka. So far, no studies have been carried out on the same. Thus, it has become a timely requirement for exploring the OHS issues faced by MSW handlers. This paper therefore aimed to explore the occupational injuries and illnesses that MSW handlers are associated with, and the basic causes which leads to such OHS issues. Accordingly, a qualitative research approach with two case studies was utilised to achieve the aim of the research. Fourteen semi-structured interviews were conducted with both authority level and worker level employees. Collected data were analysed using content analysis with the support of NVivo 12 plus software. The findings reflected that MSW handlers mostly suffer from back pain, slipping and falling, knee/calf pain, and headaches/migraine due to the nature of the job. Manual handling, negligence of use of Personal Protective Equipment (PPE), poor working environment, inadequate training and instructions, careless behaviour, health condition and age level of MSW handlers are identified as fundamental causes that greatly impact of OHS issues. Both OHS issues and respective causes are bound with organisational, cultural, economic, financial, and individual aspects that are unique to the Sri Lankan context. Finally, the findings generated through this study can be employed in many ways by respective industry practitioners to take informative decision to enhance the OHS of MSW handlers.

Background: Headache is the most frequent neurological complaint in the population and the group of tension-type headaches (TTH) is the most prevalent subtype. Nevertheless, more information about the clinical features of headaches in patients attended at specialized centers are demanded. Methods: Cross-sectional, descriptive study. Data from patients referred to an outpatient specialized headache center from 2018 to 2019 were analyzed and clinical and epidemiological information was collected. This study was authorized by the research ethics committee of the HUUFJF (CAAE 03530818.9.0000.5133). Results: Data from 153 patients were assessed. The mean age of patients was 45,6 years and most cases were women (80,4%). The most frequent diagnosis were migraine (49,7%), TTH (22,8%) and temporomandibular disorders (8,5%). The prevalence of chronic headaches was 46,6%. Analgesic abuse was identified in 32% of participants, with a higher prevalence in women (Fischer’s exact test, P=0,05). Prophylactic treatment was used by 84,3% of the subjects. Pain was self-reported mild in 21,6% of cases, moderate in 30,1% and severe in 47,1%. The pain severity was inversely proportional to age (P=0,012). The most frequent associated symptoms were photophobia (57,5%), phonophobia (56,9%), nausea/ vomiting (47,1%). Conclusions: The findings show important differences in the prevalence of headache cases in specialized centers compared to the general population. Given the high prevalence of analgesic abuse reported, the development of effective educational programs for patients and healthcare providers at primary and secondary health services, might reduce the social burden of chronic headaches and decrease the demand for consultations on specialized headache clinics.

Background: Studies across subspecialties of neurology (SON) report noninferiority of telemedicine (TM) compared with face-to-face intervention (FTF-I). Clinical scales (CS) are important tools for outcome measures in clinical care. However, which CS in FTF-I can be used in teleneurology is unclear. Objectives: Define the most used CS in studies comparing TM with FTF-I in different SON. Design and Setting/Methods: We searched PubMed and Embase for randomized controlled trials, published from 2011 to April 2021, with Key words ‘’telemedicine’’ cross-referenced with ‘’neurology’’ or neurological diseases, considering the synonyms. Results: 43 eligible studies in 400 records, from 12 countries, with 5600 patients and 8 SON: stroke (10), headache (4), epilepsy (6), cognitive disorders (7), demyelinating diseases (8), movement disorders (3), neuromuscular diseases (3), and vestibular diseases (2). The most used CS: National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS) for stroke impairment and limitation; Headache Impact Test (HIT-6) and Migraine Disability Assessment Scale (MIDAS) for headache disability; Quality Of Life in Epilepsy Inventory (QOL-31) for seizure burden; Mini-Mental State Exam (MMSE) and Zarit Burden Interview (ZBI) for cognitive function and caregiver burden in dementia care; Expanded Disability Status Scale (EDSS) and Fatigue Impact Scale (FIS) for disability and fatigue in Multiple Sclerosis; Parkinson’s disease Questionnaire (PDQ-39) and Unified Parkinson’s Disease Rating Scale (UPDRS) for QOL and disability in PD; Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R) for severity in ALS; and Vertigo Symptom Scale Short form (VSS-SF) for vertigo. Conclusions: We present feasible CS usually applied in teleneurology that can be used as important tools for future findings in TM research and practice.

In social science research, the demographic categories of ethnicity are linked to what the census bureau considers as a person’s ethnic heritage. However, these categories are based on the societal assumption that members of a given category share the same characteristics and life experiences, even though the heterogeneity between members within a category may be as diverse as between categories. The paper examines the 15 interview subjects of a research study drawn from 10 minority migrant groups, where seven of them indicated significant transcultural experiences before migrating to Australia. It argues that their lived experiences and subjectivity vary from others who migrated directly from their native countries. The formers’ diaspora consciousness and transcultural mixtures may introduce an artifact to a research study’s design, affecting the validity of the data collected. The paper examines other situations where this anomaly can occur and proposes precautions to minimize its negative effects.

Review question / Objective: The purpose of this study was to investigate the association with specific psychiatric symptoms such as depression and anxiety in pediatric patients suffering from migraine and TTH. In our meta-analysis for a detailed evaluation of depression and anxiety, we attempted to review the research using various psychodiagnostic tools. Eligibility criteria: The detailed inclusion criteria for the network meta-analysis were studies with (1) inclusion of pediatric patients; (2) patients with migraine and TTH; (3) evaluation of association between headache (migraine or TTH) and psychotic symptoms (depression and anxiety); (4) comparison between group with headache (migraine or TTH) and control group; (5) using tools for evaluating degree of depression or anxiety; and (6) written in English. Review articles, case reports, letters, and studies with insufficient data or results were excluded.

Review question / Objective: We will use a meta-regression approach to verify the dose-effect relationship between the number of electroacupuncture sessions and its effects on migraine. Condition being studied: Migraine is recurrent and chronic, requiring long-term control, but the side effects caused by long-term use limit the use of pharmacotherapy, like non-steroidal anti-inflammatory drugs (NSAIDS), ergoamines and opioids. With fewer side effects and lower cost, acupuncture is becoming a more attractive option for migraine. Relevant studies have confirmed the clinical effects of electroacupuncture on migraine and its effects on intracranial blood flow velocity, functional brain imaging and neuroinflammation. However, uncertainty exists regarding the dose-effect between electroacupuncture and migraine. In recent years, inspired by the dose-effect researches in pharmacology and epidemiology, researches focusing on the dose-effect association between acupuncture and diseases has also begun to emerge. So in this protocol, we designed to use a meta-regression approach to explore the optimal electroacupuncture dose for migraine.

A pesar de los altos niveles de urbanización, persisten los incentivos económicos para migrar de las zonas rurales a zonas urbanas. Además de la brecha salarial urbana-rural esperada, tanto la probabilidad de encontrar un empleo formal como el costo más alto de la vivienda urbana también tienen una gran importancia. La brecha salarial urbana-rural es mayor para las personas con niveles educativos más altos y es mayor entre los hombres que entre las mujeres. La brecha salarial urbana-rural es más pequeña cuando la ciudad está más cerca de su zona geográfica rural de influencia, en las ciudades mejor preparadas para absorber los flujos migratorios, y en las zonas rurales con una mayor proporción de jóvenes (que tienden a ser más móviles).

Despite the significant impact of the pandemic’s fourth wave, Vietnam’s overall strategy was seen as well planned with one of the lowest infection rates globally in 2020–2021. In June 2019, an estimated 540,000 Vietnamese migrant workers were recorded working legally in 40 countries and territories, making Vietnam a major labour exporter and one of the top ten countries to receive international remittances. Our research shows how Vietnam’s Covid-19 policy response has influenced Vietnamese migrant workers and counter-trafficking work, particularly in border areas. The research discussed four main findings. Firstly, border closures left many overseas migrant workers vulnerable and led them to rely on people smugglers. Secondly, the suspension of commercial international flights and a lack of transparency and favouritism in allocating seats on repatriation flights left many stranded. Thirdly, the national pandemic response plan suffered from limitations. Lastly, Covid-19 policies have led to new trafficking trends and challenges. Based on this evidence, the research suggests that digitalising and modernising social services could strengthen the inclusion of vulnerable groups, simplify the administrative and management process, save costs, and reduce corruption. Participation of vulnerable groups, especially ethnic minorities and overseas migrant workers, including fishers, should be ensured in national policy design and local implementation. Additionally, improving transparency and accountability of support systems could help gain citizens’ trust in the government, which would be beneficial for future crisis responses.

This study explored how measures to curtail the spread of the coronavirus (Covid-19) in Vietnam affected the livelihoods and food and nutrition security of internal migrant workers. While Vietnam has made impressive progress towards food security in the past decades, marginalised groups of people such as ethnic minorities and migrants continue to face significant challenges. The project team investigated how the pandemic affected the precarity of these groups’ income-generating opportunities and how the level of income generated affected the quality, as well as the quantity, of food consumed by migrant workers in Hanoi, the capital, and the Bac Ninh province, which hosts large industrial zones. Our research shows that income for migrant workers significantly reduced as a result of Covid-19-related lockdown measures.

Our research shows how Vietnam’s Covid-19 policy response has influenced Vietnamese migrant workers and counter-trafficking work, particularly in border areas. Vietnam is a major labour exporter and is in the top ten countries that receive international remittances. Examining the impact of the pandemic means taking into account the livelihoods and wellbeing of hundreds of thousands of overseas migrant workers. This briefing considers the impact of Vietnam’s policy response to the Covid-19 pandemic on such workers and supports adjustments in policy planning.

The Population Council, in partnership with the Global Fund to End Modern Slavery and the Norwegian Agency for Development Cooperation, undertook a multicomponent study to better understand the relationship between debt and overseas labor migration from India. The study shed light on: levels and patterns of household indebtedness among migrant households, with a special focus on households with overseas migrants; cost of overseas labor migration from India and the role of debt in financing overseas migration; role of debt in migration-related decisions; differences in work-related choices and experiences and financial vulnerabilities migrant workers experienced by household indebtedness; and migrant workers’ perceptions about financial products that can potentially reduce their financial vulnerabilities. This report describes the levels and patterns of household indebtedness and socio-demographic differentials in indebted international migrant households. It sheds light on costs incurred for overseas labor migration and the role of debt in financing migration, migration-related decisions, work-related choices and experiences, and financial vulnerabilities faced in India and overseas. A description of financial products that can potentially reduce the financial vulnerabilities of overseas labor migrants is included, as are recommendations for programs and research.

Calls for greater recognition of and attention to the influence of sex and gender on health have been longstanding, and the need for this has only been amplified by the COVID-19 pandemic. Apart from the direct effects of biological sex and socially-constructed gender differences on COVID-19 morbidity and mortality – with higher rates of severe disease and deaths among men, pandemic responses have also amplified existing gender inequalities, with women bearing the heaviest burden of the indirect health and socio-economic consequences. The interactions between sex, gender and COVID-19 are complex and evolving, and further shaped and influenced by context and the intersecting influence of other social determinants and/or identities (such as race, ethnicity, LGBTQIA or migrant status, etc.), which have exacerbated the devastating health impacts for specific women, men and gender-diverse people. Recognising both the urgency of integrating sex and gender into COVID-19 research, and the roadblocks in the way of achieving this, the United Nations University International Institute for Global Health (UNU-IIGH) and the School of Public Health at the University of the Western Cape co- convened a collaborative gender and COVID-19 research agenda-setting exercise.

Calls for greater recognition of and attention to the influence of sex and gender on health have been longstanding, and the need for this has only been amplified by the COVID-19 pandemic. Apart from the direct effects of biological sex and socially-constructed gender differences on COVID-19 morbidity and mortality – with higher rates of severe disease and deaths among men, pandemic responses have also amplified existing gender inequalities, with women bearing the heaviest burden of the indirect health and socio-economic consequences. The interactions between sex, gender and COVID-19 are complex and evolving, and further shaped and influenced by context and the intersecting influence of other social determinants and/or identities (such as race, ethnicity, LGBTQIA or migrant status, etc.), which have exacerbated the devastating health impacts for specific women, men and gender-diverse people. Recognising both the urgency of integrating sex and gender into COVID-19 research, and the roadblocks in the way of achieving this, the United Nations University International Institute for Global Health (UNU-IIGH) and the School of Public Health at the University of the Western Cape co- convened a collaborative gender and COVID-19 research agenda-setting exercise.