Rozprawy doktorskie na temat „Microfluidic method”
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Nguyen, Khanh H. (Khanh Huy). "Hot embossing as a method for rapid prototyping microfluidic devices". Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85789.
Pełny tekst źródłaTitle as it appears in Degrees awarded program, September 17, 2003: Design and analysis of a hot embossing machine and the effects of toolware and accuracy of resin replication of high aspect ratio microfluidic features Cataloged from PDF version of thesis.
Includes bibliographical references (pages 132-135).
Hot embossing is a growing technology proven to be capable of reproducing micro-scale features on thermoplastics and can be an effective process for rapid prototyping microfluidic devices with high aspect ratio micro features. Advantages of this manufacturing process can include tooling flexibility, fast production time, low capital cost and a vast selection of production materials. A greater understanding on the micro feature transferring capabilities and use limits of tools are needed so that hot embossing may advance to becoming a practical technique for producing microfluidic parts. This work focuses on both the design and analysis of a hot embossing system and a brass tool to replicate an existing functional high aspect ratio micro feature onto Polymethyl methacrylate (PMMA). The aspect ratio of features ranged from 10:1 to 4,000:1. Optimal embossing parameters used a pressure of 3.5kN, hold time of 12 minutes, tool temperatures of 140°C and substrate temperature of 130°C to produce parts that filled shoulder heights and widths up to 97% and 90%, respectively. The wearing of features on the metal tool were also characterized for purposes of understanding the limits on tool use and was found that a maximum range of +/-3[mu]m in dimensional change existed. Gains in tool dimensions were then mainly attributed to the deposition of embossed materials onto the tool. The study further determined a method for creating usable resin tool copies that exhibited a replication accuracy of less than 2%, on average, for micron size features.
by Khanh H. Nguyen.
M. Eng. in Manufacturing
Lustrino, Michelle E. (Michelle Elizabeth). "The development of an innovative bonding method for microfluidic applications". Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67622.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (p. 145-149).
The field of microfluidics has powerful applications in low-cost healthcare diagnostics, DNA analysis, and fuel cells, among others. As the field moves towards commercialization, the ability to robustly manufacture these devices at low cost is becoming more important. One of the many challenges in microfluidic manufacturing is the reliable sealing of the microfluidic chips once the channels have been generated. This work was an investigation of innovative ways to robustly heat the substrate-cover plate interface of a microfluidic device for the purpose of bonding and sealing the microfluidic channels. An extensive literature review revealed the benefits of interfacial heating, and both simulations and experimental investigations were used to evaluate a few different methods. Ultimately, a unique method was established that uses light to provide both the bonding energy and the illumination for an in-process vision system for real-time viewing and control of the bonding process. The process results in the generation of a homogenous and optically clear bond, and preliminary tests show that when properly controlled, a bond with minimal microchannel deformation can be created.
by Michelle E. Lustrino.
S.M.
Wu, Jun, i 吴隽. "Drug delivery devices fabricated by microfluidic method and their applications in long-term antimicrobial therapy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/198816.
Pełny tekst źródłapublished_or_final_version
Orthopaedics and Traumatology
Doctoral
Doctor of Philosophy
PENNELLA, FRANCESCO. "Analysis of microscale flows in tissue engineering systems and microfluidic devices". Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2514479.
Pełny tekst źródłaJeon, Jessie Sungyun. "3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61871.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (p. 48-51).
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS.
by Jessie Sungyun Jeon.
S.M.
Winer, Michael Hubert. "A three-dimensional (3D) defocusing-based particle tracking method and applications to inertial focusing in microfluidic devices". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50194.
Pełny tekst źródłaApplied Science, Faculty of
Graduate
Othman, Rahimah. "Production of functional pharmaceutical nano/micro-particles by solvent displacement method using advanced micro-engineered dispersion devices". Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/22905.
Pełny tekst źródłaMurali, Divya. "A Sampling Method for the Reduction of Power Consumption in Battery Operated UHF Receivers". University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1220634056.
Pełny tekst źródłaDuford, David. "Instrumentation, fabrication techniques and method development for sample introduction, preparation and extraction on centrifugal microfluidic devices in motion". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110441.
Pełny tekst źródłaLes polluants ont des impacts importants sur la santé et l'environnement résultant à des restrictions accrues des limites législatives. Cette surveillance environnementale accrue pousse les chimistes analytiques vers l'automatisation et la miniaturisation des méthodes de référence actuelles. L'analyse d'échantillons environnementaux solides bénéficiera de cette envolée par le développement de nouveaux instruments et techniques de manipulation d'échantillon via des dispositifs microfluidiques centrifuges qui intègrent des réactions à étapes multiples sur un dispositif unique.Afin d'étudier et d'optimiser les dispositifs microfluidiques centrifuges en mouvement, des plateformes motorisées qui incluent une caméra, une lumière stroboscopique et une variété d'autres composantes périphériques ont été développées. Celles-ci ont permis le contrôle efficace des dispositifs tout au long des séquences giratoires et l'acquisition simultanée de séries de photographies en arrêt sur image.Des méthodologies sont présentées pour l'introduction, la préparation et l'extraction d'échantillons sur des dispositifs microfluidiques centrifuges en mouvement. Ceci fut réalisé grâce à la recherche de techniques de fabrication hybrides incluant l'utilisation d'imprimantes 3D menant au développement d'une interface permettant l'introduction de solutés à concentrations variables aux dispositifs en mouvement. De plus, l'interaction d'aimants mobiles intégrés avec une série d'aimants fixes placée sous les dispositifs en mouvement a mené au développement des techniques de préparation d'échantillons solides par force magnétique et d'extraction liquide-solide d'échantillons par force magnétique. De nouvelles méthodes automatisées et miniaturisées ont été développées pour l'analyse d'espèces environnementales importantes telles que les hydrocarbures polycycliques aromatisés et les pesticides dans des échantillons solides.
Kim, Ho Jun. "Theoretical and numerical studies of chaotic mixing". Diss., Texas A&M University, 2008. http://hdl.handle.net/1969.1/85940.
Pełny tekst źródłaLafferty, William Henry. "DEVELOPMENT OF A HIGH PRECISION QUANTUM DOT SYNTHESIS METHOD UTILIZING A MICROFLUIDIC REACTOR AND IN-LINE FLUORESCENCE FLOW CELL". DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1317.
Pełny tekst źródłaStewart-James, Samantha Ann. "Development of a microfluidic flow cytometry platform with fluorescence and light scattering detection for the rapid characterization of circulating tumor cells". Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/19078.
Pełny tekst źródłaDepartment of Chemistry
Christopher T. Culbertson
Circulating tumor cells (CTCs) have become a key component in the identification and treatment of cancer. Once dislodged from the main tumor, CTCs travel through the bloodstream and cause metastasis. Early detection and identification of these cells can help in the evaluation and prognosis of various types of cancer, as well as assisting in patient treatments by determining the spread of the disease. Here, a high-throughput microfluidic analysis technique is described that can efficiently detect and identify cells, with the specific identification of CTCs as a future application through fluorescent labeling in mind. As proof of principle, the device has been shown to detect and characterize individual human Jurkat (T-lymphocyte) cells at a rate of 100 cells/minute. The device employs micro-scale flow focusing to isolate individual cells. The cells are detected using both light scattering and laser-induced fluorescence to evaluate cell size and surface functionality.
Banerjee, Ansuman. "A polarization isolation method for measurement of fluorescence assays in a microfluidic system using organic electronics for application to point-of-care diagnostics". Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1218238821.
Pełny tekst źródłaAdvisor: David Klotzkin (Committee Chair), Ian Papautsky (Committee Member), Marc Cahay (Committee Member), Fred Beyette (Committee Member), Paul Bishop (Committee Member). Title from electronic thesis title page (viewed Jan. 18, 2009). Keywords: OLED; OPD; microfluidic; lab-on-a-chip; on-chip fluorescence detector; MEMS; thin films; organic electronics. Includes abstract. Includes bibliographical references.
Guglielmino, Maud. "Développement d'une nouvelle méthode analytique du formaldéhyde dans l'air basée sur un dispositif microfluidique". Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF048.
Pełny tekst źródłaFormaldehyde (HCHO) is a major pollutant in indoor air. The objective of this work is to realize the scientific and technological advances required to obtain an analytical method based on a microfluidic device to measure air formaldehyde combining precision, selectivity, analysis speed with for major objective a sufficient autonomy on a long time, typically one month. The principle of the method was initially based on three key steps, the gaseous formaldehyde uptake in solution, the formaldehyde derivatization reaction, then the detection of reaction product by colorimetry or fluorimetry. The method has finally advanced toward only two definite steps thanks to the use of an innovative microfluidic device in which uptake and reaction take place simultaneously. The study of analytical performances of the device allows to validate the method developedduring this work
Hartmann, Michael. "Microfluidic Methods for Protein Microarrays". Doctoral thesis, KTH, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26083.
Pełny tekst źródłaQC 20101112
Zhang, Yingbo. "Microfluidic methods for biomolecular analysis". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274931.
Pełny tekst źródłaaf, Klinteberg Ludvig. "Computational methods for microfluidics". Licentiate thesis, KTH, Numerisk analys, NA, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-116384.
Pełny tekst źródłaQC 20130124
Herling, Therese Windelborg. "Microfluidic methods for quantitative protein studies". Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709392.
Pełny tekst źródłaAshok, Praveen Cheriyan. "Integration methods for enhanced trapping and spectroscopy in optofluidics". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2546.
Pełny tekst źródłaKlauber, Kameron L. "Rapid prototyping method for a microfluidics device". Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/74446.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (p. 12).
The product design process can be described as a number of steps taken to turn an idea into a reality. One particular design process of creating a microfluidics device was studied and analyzed. A device containing channels for fluid flow presents a number of challenges for designers. The particular device in this study had a number of specifications, which include a small scale, a necessity to hold fluid, and a desire to control fluid flow. The overall process for developing this product can be broken into the idea, concept development, 3D CAD, simulations, 3D prototyping, assembly, and biochemistry testing. This is one process that has been completed and studied to identify certain design decisions related to this particular device. Further testing and future design iterations will be needed to prove the success of this particular device.
by Kameron L. Klauber.
S.B.
Russom, Aman. "Microfluidic bead-based methods for DNA analysis". Doctoral thesis, KTH, Skolan för elektro- och systemteknik (EES), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-155.
Pełny tekst źródłaQC 20101008
Chawan, Aschvin Bhagirath. "Novel methods for microfluidic mixing and control". Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/54016.
Pełny tekst źródłaMaster of Science
Ung, Warren Lloyd. "Microfluidic Methods for High-Throughput Biological Screening". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845504.
Pełny tekst źródłaEngineering and Applied Sciences - Engineering Sciences
Rossetto, Nicola. "Materials and methods for modular microfluidic devices". Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422583.
Pełny tekst źródłaQuesto lavoro di tesi tratta dello studio di materiali e metodi che possono essere applicati alla realizzazione di dispositivi microfluidici (DMF). In particolare l’attenzione è rivolta ai dispositivi modulari, piuttosto che a quelli altamente integrati. Le ragioni dietro questa scelta sono spiegate in dettaglio nella Sezione 1.2 di questa tesi, ma possono essere qui sintetizzate nel fatto che anche se i DMF integrati offrono grandi vantaggi in termini di dimensioni finali, i dispositivi modulari sono più versatili, e quindi particolarmente utili per applicazioni nel campo della ricerca. La prima parte del lavoro qui riportato descrive le tecniche di microfabbricazione utilizzate per la realizzazione di moduli microfluidici monofunzionali. I dispositivi sono stati realizzati per replica molding in PDMS a partire da master in SU-8. I master sono stati a loro volta fabbricati tramite litografia UV con maschera oppure per scrittura laser diretta ad uno o due fotoni, a seconda dei requisiti di risoluzione. Il replica molding è un metodo molto rapido ed efficiente per realizzare DMF, ma presenta alcuni limiti per quanto riguarda la forma delle strutture che è possibile replicare con successo. Alla luce di questo, un sol-gel fotopolimerizzabile ibrido organico/inorganico viene qui proposto e testato come materiale alternativo per la fabbricazione di DMF. I risultati della caratterizzazione rivelano che questo materiale è biocompatibile e presenta proprietà meccaniche migliori di quelle del PDMS, ma strutture con più di una dimensione eccedente i pochi micrometri tendono a sviluppare cricche, cosa che impedisce l’utilizzo di questo sol-gel come materiale massivo. Ciononostante, questo sol-gel potrebbe venir efficacemente impiegato per la realizzazione di sottostrutturazioni all’interno di canali microfluidici. Dopo questo studio sui materiali, un modulo microfluidico per il mescolamento è proposto e testato. Dato che le condizioni di flusso laminare sono dominanti all’interno dei microcanali, per ottenere un mescolamento efficiente in un DMF è necessario includere nel dispositivo un miscelatore specificatamente progettato. Il modulo proposto utilizza delle ostruzioni all’interno del microcanale per perturbare il flusso laminare e quindi favorire il mescolamento. Con l’aiuto di alcune simulazioni numeriche, le geometrie più efficienti sono state individuate, e due layout particolarmente promettenti sono stati realizzati e caratterizzati sperimentalmente misurando la diluizione di un fluoroforo (mescolamento tra una soluzione del fluoroforo e puro solvente) attraverso la microscopia confocale di fluorescenza. A seguire, viene riportata la fabbricazione e caratterizzazione di un modulo optofluidico per la deflessione della luce. Questo dispositivo utilizza un flusso segmentato acqua/aria generato da una giunzione a T per trasmettere o riflettere (per riflessione totale interna) alternativamente un fascio laser. Questa alternanza è periodica, e la sua frequenza può essere controllata variando la portata dei flussi iniettati di aria e acqua. Inoltre, il duty cycle del modulo è stato caratterizzato, e viene proposto e verificato un metodo per modularlo attraverso un aumento della temperatura dell’acqua. Infine, vengono descritti alcuni tentativi di generare un PDMS nanoporoso con basso indice di rifrazione. La messa a punto di una procedura efficiente per la fabbricazione di questo genere di materiale porterebbe alla possibilità di usare i classici canali microfluidici come guide d’onda. Al momento questi tentativi hanno avuto solo parziale successo, ma i maggiori punti di criticità sono stati identificati, e vengono proposte alcune strategie per il loro futuro superamento.
Mukhitov, Nikita. "Microfluidic Methods for the Study of Biological Dynamics". Thesis, The Florida State University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10633959.
Pełny tekst źródłaThe work in this dissertation presents microfluidic methods developed for the study of biological dynamics. The requirements for the methods development was to create approaches with the ability to perform dynamic cell stimulation, measurement, and sample preparation. The methods presented herein were initially developed for the study of pancreatic islet biology but are expected to be translatable to other applications. In another study, a method to interface transmission electron microscopy (TEM) with microfluidics methods was developed.
The primary biological topic of interest investigated was the mechanisms of inter-islet synchronization. To test this, a microfluidic device fabricated from poly(dimethylsiloxane) (PDMS) was used to culture and stimulate pancreatic islets. Intracellular calcium ([Ca2+]i) imaging was performed with a fluorescent indicator, Fura-2-acetoxymethyl ester (Fura-2 AM). Under constant glucose (11 mM), islets demonstrated asynchronous and heterogeneous [Ca2+]i oscillations that drifted in period. However, when exposed to a glucose wave (11+/– 1 mM, 5 min period) islets were entrained to a common and consistent [Ca2+]i oscillation mode. The effect of islet entrainment on cellular function was investigated by measuring gene expression levels with microarray profiling. Calcium-dependent genes were found to be differentially expressed. Furthermore, it was speculated that islet entrained produced a beneficial effect on cell function and upkeep.
While [Ca2+]i imaging is an acceptable proxy measurement for insulin, it is not a viable reporter for other islet peptides and direct measurement is desired. Electrophoretic affinity assays can be performed on a microfluidic device in a serial manner to measure peptide release from an on-chip cell culture in near real-time. Successful analysis of electrophoretic affinity assays depends strongly on the preservation of the affinity complex during separations. Elevated separation temperatures due to Joule heating promotes complex dissociation leading to a reduction in sensitivity. To address this limitation, a method to cool a glass microfluidic chip for performing an affinity assay for insulin was achieved by a Peltier cooler localized over the separation channel. The Peltier cooler allowed for rapid stabilization of temperatures, with 21 °C the lowest temperature that was possible to use without producing detrimental thermal gradients throughout the device. Kinetic capillary electrophoresis analysis was utilized as a diagnostic of the affinity assay and indicated that optimal conditions were at the highest attainable separation voltage, 6 kV, and the lowest separation temperature, 21 °C, leading to 3.4% dissociation of the complex peak during the separation. These optimum conditions were used to generate a calibration curve and produced 1 nM limits of detection (LOD), representing a 10-fold improvement over non-thermostated conditions.
To date, most approaches for measurement of rapid changes in insulin levels rely on separations, making the assays difficult to translate to non-specialist laboratories. To enable rapid measurements of secretion dynamics from a single islet in a manner that will be more suitable for transfer to non-specialized laboratories, a microfluidic online fluorescence anisotropy immunoassay was developed. A single islet was housed inside a microfluidic chamber and stimulated with varying glucose levels from a gravity-based perfusion system. The total effluent of the islet chamber containing the islet secretions was mixed with gravity-driven solutions of insulin antibody and cyanine-5 (Cy5) labeled insulin. After mixing was complete, a linearly polarized 635 nm laser was used to excite the immunoassay mixture and the emission was split into parallel and perpendicular components for determination of anisotropy. Key factors for reproducible anisotropy measurements, including temperature homogeneity and flow rate stability were optimized, which resulted in a 4 nM LOD for insulin with < 1% RSD of anisotropy values. The capability of this system for measuring insulin secretion from single islets was shown by stimulating an islet with varying glucose levels. As the entire analysis is performed optically, this system should be readily transferable to other laboratories.
To increase the number of analytes that can be simultaneously monitored by a fluorescence anisotropy immunoassay, frequency encoding was introduced. As a demonstration of the method, simultaneous competitive immunoassays for insulin and glucagon were performed by measuring the ratio of bound and free Cy5-insulin and fluorescein isothiocyanate (FITC)-glucagon in the presence of their respective antibodies. A vertically polarized 635 nm laser was pulsed at 73 Hz and used to excite Cy5-insulin, while a vertically polarized 488 nm laser pulsed at 137 Hz excited FITC-glucagon. The total emission was split into parallel and perpendicular polarizations and collected onto separate photomultiplier tubes. The signals from each channel were demodulated using a fast Fourier transform, resolving the contributions from each fluorophore. Anisotropy calculations were carried out using the magnitude of the peaks in the frequency domain. The method produced the expected shape of the calibration curves with LOD of 0.6 and 5 nM for insulin and glucagon, respectively. (Abstract shortened by ProQuest.)
Morthomas, Julien. "Intéractions hydrodynamiques entre colloïdess confinés le long d'une paroi". Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13882/document.
Pełny tekst źródłaApplying a steady electric field or a constant thermal gradient to a colloidal suspension induces a finite velocity of the dispersed particles. The motion of particles is not due to a net body force like in sedimentation but to interfacial forces acting on the electric double layer at their surface. These forces involve a surface flow, which, in turn, results in a velocity field of the surrounding fluid in 1/r³ in the opposite direction of the particle displacement, with r the distance from the centre of the particle. In this work we consider a somewhat different situation, where the suspension is confined to a semi-infinite half space. The particle, under the action of the applied field, is trapped against the solid interface. Still, the creep flow remains; more precisely the particle continues to pump the fluid in the opposite direction. As a consequence there arises a lateral flow along the solid surface towards the particle. Thus others particles inserting themselves in this flow undergo drag forces and form clusters. Particles aggregation has been observed in Electrophoresis deposition and more recently in Thermophoresis deposition for micron sized polystyrene beads in aqueous solution. The total velocity field takes a form significantly more complicated than in the above mentioned unbounded cases; it must satisfy boundary conditions both at the particle surface and at the confining wall. Using the perturbative method of reflections or Oseen method based on Fourier transform we resolve the Stokes equation and find an analytic solution for the drag flow along the interface in powers of the ratio e=a/h of particle radius and wall distance. The usual solution at the zero order induces poor approximation, when following corrections in e involves better results in agreement with experimental measurements of hydrodynamic pair potential between two particles along a wall
White, Celesta E. "Advanced Methods, Materials, and Devices for Microfluidics". Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5287.
Pełny tekst źródłaVisitkul, Viput. "Novel method for high throughput FRET screening with microfluidics". Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/novel-method-for-high-throughput-fret-screening-with-micro-uidics(f5b7a493-ff9c-42d0-889d-3f773591a97e).html.
Pełny tekst źródłaKilimnik, Alexander. "Cross stream migration of compliant capsules in microfluidic channels". Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43669.
Pełny tekst źródłaCoquinco, Bernard. "Alternative replica molding methods for polymer based microfluidic channels". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50190.
Pełny tekst źródłaApplied Science, Faculty of
Graduate
Belotti, Yuri. "Microfluidic methods for investigating cell migration and cell mechanics". Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/fb5ac03d-a752-45a1-8b95-37c8180dc7d9.
Pełny tekst źródłaRose, Klint A. "Microfluidic manipulation and detection methods for metal microbarcode particles /". May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Pełny tekst źródłaTeo, Adrian J. "Active Droplet Control and Manipulation in Microfluidics". Thesis, Griffith University, 2020. http://hdl.handle.net/10072/392033.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Eng & Built Env
Science, Environment, Engineering and Technology
Full Text
Carlborg, Carl Fredrik. "Development of materials, surfaces and manufacturing methods for microfluidic applications". Doctoral thesis, KTH, Mikrosystemteknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-38605.
Pełny tekst źródłaQC 20110907
Salem, Mohamed Yafia Okba. "Enhanced actuation and fabrication methods for integrated digital microfluidic systems". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60456.
Pełny tekst źródłaApplied Science, Faculty of
Engineering, School of (Okanagan)
Graduate
Klepáčová, Ivana. "Detekce biomarkerů pomocí elektrochemických metod mikrofluidickým čipem". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-317012.
Pełny tekst źródłaDawson, Amy. "Paper microfluidics for clinical diagnostics using colourimetric detection methods". Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10515.
Pełny tekst źródłaaf, Klinteberg Ludvig. "Fast and accurate integral equation methods with applications in microfluidics". Doctoral thesis, KTH, Numerisk analys, NA, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185758.
Pełny tekst źródłaDenna avhandling behandlar beräkningsmetoder för strömning på mikroskalan, även känt som mikrofluidik. Detta val av ämne motiveras av aktuell forskning inom biologisk fysik och miniatyrisering, där det ofta finns ett behov av att förstå komplexa flöden med strukturer på mikroskalan. Datorsimuleringar är ett viktigt verktyg för att öka den förståelsen. Avhandlingens första, och mindre, del beskriver en numerisk metod för att simulera flerfasflöden med olösliga surfaktanter och rörliga kontaktlinjer. Metoden är baserad på en uppdelning av gränsskiktet, som tillåter det att representeras med lokala, Euleriska nät. Detta skapar naturliga förutsättningar för lösning av den PDE som styr surfaktantkoncentrationen på gränsskiktets yta. Avhandlingens andra, och större, del beskriver ett ramverk för att med hjälp av en randintegralformulering simulera stora system av styva partiklar i tredimensionellt, periodiskt Stokesflöde. Detta ramverk kan lösa flödesekvationerna mycket noggrant, tack vare den inneboende höga noggrannheten hos metoder för numerisk integration på släta ytor. Metoden är också snabb, tack vare den naturliga kopplingen mellan randintegralmetoder och snabba summeringsmetoder. Utvecklingen av ramverket för partikelsimuleringar täcker ett brett spektrum av ämnet numerisk analys. För snabba beräkningar på stora system används en snabb Ewaldsummeringsmetod vid namn spektral Ewald. Denna metod har anpassats för att fungera med den randintegralformulering för Stokesflöde som används. För noggrann numerisk integration används en metod kallad expansionskvadratur (eng. Quadrature by Expansion), som också har utvecklats för att passa samma Stokesformulering. Denna metod har även gjorts snabbare genom en nyutvecklad metod baserad på geometriska symmetrier. För att bättre förstå kvadraturmetodens inneboende fel har en analys baserad på konturintegraler och residykalkyl utförts, vilket har resulterat i väldigt noggranna felestimat.
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Lu, Chunmeng. "Development of novel micro-embossing methods and microfluidic designs for biomedical applications". Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1156820643.
Pełny tekst źródłaWith, Sebastian [Verfasser]. "Microfluidics as a method to follow dynamic assembly of colloidal systems / Sebastian With". München : Verlag Dr. Hut, 2015. http://d-nb.info/1075409209/34.
Pełny tekst źródłaSun, Xinyu. "Fault Modeling and Fault Type Distinguishing Test Methods for Digital Microfluidics Chips". University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380557053.
Pełny tekst źródłaFidalgo, Luis Miguel. "Novel methods for droplet fusion, extraction and analysis in multiphase microfluidics". Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611619.
Pełny tekst źródłaMoon, Jiyoung. "Rheological Behavior of Complex Fluid with Deformable and Rigid Particles". Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17106.
Pełny tekst źródłaShah, Kumar. "Quantitative Analysis of Tobacco Specific Nitrosamine in Human Urine Using Molecularly Imprinted Polymers as a Potential Tool for Cancer Risk Assessment". VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1954.
Pełny tekst źródłaTran, Thi Thuy. "Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications". Doctoral thesis, Stockholms universitet, Institutionen för analytisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-83355.
Pełny tekst źródłaAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 3: Manuscript.
Fiabane, Joe. "A novel method of producing microbubbles for targeted drug delivery". Thesis, Robert Gordon University, 2016. http://hdl.handle.net/10059/1579.
Pełny tekst źródłaTartagni, Ottavia <1992>. "Advanced cell culture platforms: methods for drug testing with microfluidics and microstructured devices". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10234/1/Tartagni_Ottavia_Advanced%20cell%20culture%20platforms%20methods%20for%20drug%20testing.pdf.
Pełny tekst źródłaRua, Gonzalez Diego. "Synthèse de matériaux catalytiques de type oxydes mixtes pour la production de méthanol par la précipitation en flux continu en système microfluidique". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF001.
Pełny tekst źródłaGlobal warming is a concern for the current and future generations due to the increasing greenhouse gases (GHG) emissions to the atmosphere, mainly due to the dependence on fossil fuels. The use of alternative fuels such as sustainable methanol produced from renewable H2 and from CO2 would contribute to reduce the GHG emissions and the effects of climate change. The synthesis of methanol using CO2 rich feedstock is preferentially done by using a solid catalyst composed of CuO, ZnO and ZrO2. This type of catalyst can be produced by coprecipitation of the metal species using a microfluidic device, with advantages that have been demonstrated over catalysts synthesized by batch coprecipitation. In this work, different catalysts for the hydrogenation of CO2 to methanol were synthesized using the microfluidic technique under different conditions, in order to explore different synthesis parameters that could lead to the development of more active catalysts. The differences in the properties and activity between a catalyst synthesized by the microfluidic method and another synthesized by the batch method were investigated, followed by an exploration of the effects of the aging time and the coprecipitation temperature on the catalysts. Lastly, the effect of different compositions of catalysts on the properties and activity were determined, by investigating different CuO contents, the use of CeO2 as a catalyst promoter, and the use of In2O3 as a catalyst promoter and as active metal
Steiner, Thomas. "Dissipative particle dynamics simulation of microfluidic systems with fluid particle methods on high performance computers". Aachen Shaker, 2009. http://d-nb.info/995271100/04.
Pełny tekst źródłaAlabi, Oluwarotimi Ocilama. "The development of microfluidic and surface enhanced Raman methods for petroleum analysis : asphaltene and naphthenic acids". Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228647.
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