Gotowe bibliografie tematyczne / Microfluidic devices

Gotowa bibliografia na temat „Microfluidic devices”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 6 września 2023

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Artykuły w czasopismach na temat "Microfluidic devices"

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Ballacchino, Giulia, Edward Weaver, Essyrose Mathew, Rossella Dorati, Ida Genta, Bice Conti i Dimitrios A. Lamprou. "Manufacturing of 3D-Printed Microfluidic Devices for the Synthesis of Drug-Loaded Liposomal Formulations". International Journal of Molecular Sciences 22, nr 15 (28.07.2021): 8064. http://dx.doi.org/10.3390/ijms22158064.

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Microfluidic technique has emerged as a promising tool for the production of stable and monodispersed nanoparticles (NPs). In particular, this work focuses on liposome production by microfluidics and on factors involved in determining liposome characteristics. Traditional fabrication techniques for microfluidic devices suffer from several disadvantages, such as multistep processing and expensive facilities. Three-dimensional printing (3DP) has been revolutionary for microfluidic device production, boasting facile and low-cost fabrication. In this study, microfluidic devices with innovative micromixing patterns were developed using fused deposition modelling (FDM) and liquid crystal display (LCD) printers. To date, this work is the first to study liposome production using LCD-printed microfluidic devices. The current study deals with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes with cholesterol (2:1) prepared using commercial and 3D-printed microfluidic devices. We evaluated the effect of microfluidic parameters, chip manufacturing, material, and channel design on liposomal formulation by analysing the size, PDI, and ζ-potential. Curcumin exhibits potent anticancer activity and it has been reported that curcumin-loaded liposomes formulated by microfluidics show enhanced encapsulation efficiency when compared with other reported systems. In this work, curcumal liposomes were produced using the developed microfluidic devices and particle sizing, ζ-potential, encapsulation efficiency, and in vitro release studies were performed at 37 °C.
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Cai, Jianchen, Jiaxi Jiang, Jinyun Jiang, Yin Tao, Xiang Gao, Meiya Ding i Yiqiang Fan. "Fabrication of Transparent and Flexible Digital Microfluidics Devices". Micromachines 13, nr 4 (23.03.2022): 498. http://dx.doi.org/10.3390/mi13040498.

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This study proposed a fabrication method for thin, film-based, transparent, and flexible digital microfluidic devices. A series of characterizations were also conducted with the fabricated digital microfluidic devices. For the device fabrication, the electrodes were patterned by laser ablation of 220 nm-thick indium tin oxide (ITO) layer on a 175 μm-thick polyethylene terephthalate (PET) substrate. The electrodes were insulated with a layer of 12 μm-thick polyethylene (PE) film as the dielectric layer, and finally, a surface treatment was conducted on PE film in order to enhance the hydrophobicity. The whole digital microfluidic device has a total thickness of less than 200 μm and is nearly transparent in the visible range. The droplet manipulation with the proposed digital microfluidic device was also achieved. In addition, a series of characterization studies were conducted as follows: the contact angles under different driving voltages, the leakage current density across the patterned electrodes, and the minimum driving voltage with different control algorithms and droplet volume were measured and discussed. The UV–VIS spectrum of the proposed digital microfluidic devices was also provided in order to verify the transparency of the fabricated device. Compared with conventional methods for the fabrication of digital microfluidic devices, which usually have opaque metal/carbon electrodes, the proposed transparent and flexible digital microfluidics could have significant advantages for the observation of the droplets on the digital microfluidic device, especially for colorimetric analysis using the digital microfluidic approach.
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Zhu, Zhiyuan, Fan Zeng, Zhihua Pu i Jiyu Fan. "Conversion Electrode and Drive Capacitance for Connecting Microfluidic Devices and Triboelectric Nanogenerator". Electronics 12, nr 3 (19.01.2023): 522. http://dx.doi.org/10.3390/electronics12030522.

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Microfluidics is a technique that uses channels of tiny sizes to process small amounts of fluid, which can be used in biochemical detection, information technology, and other fields. In the process of microfluidic development, there are many problems that need to be solved urgently. Many microfluidic systems require the support of external devices, which increases the construction cost, and the electronic interface technology is not mature. A triboelectric nanogenerator (TENG) can harvest mechanical energy and turn it into electrical energy. It has been greatly developed now and is widely used in various fields. Nowadays, many studies are committed to the study of TENGs and microfluidic systems. The microfluidics device can be combined with a TENG to convert fluid mechanical signals into electrical signals for transmission. Meanwhile, TENGs can also act as a high-voltage source to drive microfluidic motion. In this paper, we reviewed the development of microfluidics and related technologies of microfluidic systems in conjunction with TENGs and discussed the form of electronic interface between microfluidic systems and TENG devices.
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Kurniawan, Yehezkiel Steven, Arif Cahyo Imawan, Sathuluri Ramachandra Rao, Keisuke Ohto, Wataru Iwasaki, Masaya Miyazaki i Jumina. "Microfluidics Era in Chemistry Field: A Review". Journal of the Indonesian Chemical Society 2, nr 1 (31.08.2019): 7. http://dx.doi.org/10.34311/jics.2019.02.1.7.

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By miniaturizing the reactor dimension, microfluidic devices are attracting world attention and starting the microfluidic era, especially in the chemistry field because they offer great advantages such as rapid processes, small amount of the required reagents, low risk, ease and accurate control, portable and possibility of online monitoring. Because of that, microfluidic devices have been massively investigated and applied for the real application of human life. This review summarizes the up-to-date microfluidic research works including continuous-flow, droplet-based, open-system, paper-based and digital microfluidic devices. The brief fabrication technique of those microfluidic devices, as well as their potential application for particles separation, solvent extraction, nanoparticle fabrication, qualitative and quantitative analysis, environmental monitoring, drug delivery, biochemical assay and so on, are discussed. Recent perspectives of the microfluidics as a lab-on-chip or micro total analysis system device and organ-on-chip are also introduced.
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Tang, Xiaoqing, Qiang Huang, Tatsuo Arai i Xiaoming Liu. "Cell pairing for biological analysis in microfluidic devices". Biomicrofluidics 16, nr 6 (grudzień 2022): 061501. http://dx.doi.org/10.1063/5.0095828.

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Cell pairing at the single-cell level usually allows a few cells to contact or seal in a single chamber and provides high-resolution imaging. It is pivotal for biological research, including understanding basic cell functions, creating cancer treatment technologies, developing drugs, and more. Laboratory chips based on microfluidics have been widely used to trap, immobilize, and analyze cells due to their high efficiency, high throughput, and good biocompatibility properties. Cell pairing technology in microfluidic devices provides spatiotemporal research on cellular interactions and a highly controlled approach for cell heterogeneity studies. In the last few decades, many researchers have emphasized cell pairing research based on microfluidics. They designed various microfluidic device structures for different biological applications. Herein, we describe the current physical methods of microfluidic devices to trap cell pairs. We emphatically summarize the practical applications of cell pairing in microfluidic devices, including cell fusion, cell immunity, gap junction intercellular communication, cell co-culture, and other applications. Finally, we review the advances and existing challenges of the presented devices and then discuss the possible development directions to promote medical and biological research.
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Männel, Max J., Elif Baysak i Julian Thiele. "Fabrication of Microfluidic Devices for Emulsion Formation by Microstereolithography". Molecules 26, nr 9 (10.05.2021): 2817. http://dx.doi.org/10.3390/molecules26092817.

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Droplet microfluidics—the art and science of forming droplets—has been revolutionary for high-throughput screening, directed evolution, single-cell sequencing, and material design. However, traditional fabrication techniques for microfluidic devices suffer from several disadvantages, including multistep processing, expensive facilities, and limited three-dimensional (3D) design flexibility. High-resolution additive manufacturing—and in particular, projection micro-stereolithography (PµSL)—provides a promising path for overcoming these drawbacks. Similar to polydimethylsiloxane-based microfluidics 20 years ago, 3D printing methods, such as PµSL, have provided a path toward a new era of microfluidic device design. PµSL greatly simplifies the device fabrication process, especially the access to truly 3D geometries, is cost-effective, and it enables multimaterial processing. In this review, we discuss both the basics and recent innovations in PµSL; the material basis with emphasis on custom-made photopolymer formulations; multimaterial 3D printing; and, 3D-printed microfluidic devices for emulsion formation as our focus application. Our goal is to support researchers in setting up their own PµSL system to fabricate tailor-made microfluidics.
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Soum, Veasna, Sooyong Park, Albertus Ivan Brilian, Oh-Sun Kwon i Kwanwoo Shin. "Programmable Paper-Based Microfluidic Devices for Biomarker Detections". Micromachines 10, nr 8 (2.08.2019): 516. http://dx.doi.org/10.3390/mi10080516.

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Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.
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Yap, Boon, Siti M.Soair, Noor Talik, Wai Lim i Lai Mei I. "Potential Point-of-Care Microfluidic Devices to Diagnose Iron Deficiency Anemia". Sensors 18, nr 8 (10.08.2018): 2625. http://dx.doi.org/10.3390/s18082625.

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Over the past 20 years, rapid technological advancement in the field of microfluidics has produced a wide array of microfluidic point-of-care (POC) diagnostic devices for the healthcare industry. However, potential microfluidic applications in the field of nutrition, specifically to diagnose iron deficiency anemia (IDA) detection, remain scarce. Iron deficiency anemia is the most common form of anemia, which affects billions of people globally, especially the elderly, women, and children. This review comprehensively analyzes the current diagnosis technologies that address anemia-related IDA-POC microfluidic devices in the future. This review briefly highlights various microfluidics devices that have the potential to detect IDA and discusses some commercially available devices for blood plasma separation mechanisms. Reagent deposition and integration into microfluidic devices are also explored. Finally, we discuss the challenges of insights into potential portable microfluidic systems, especially for remote IDA detection.
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Chen, Luyao, Xin Guo, Xidi Sun, Shuming Zhang, Jing Wu, Huiwen Yu, Tongju Zhang, Wen Cheng, Yi Shi i Lijia Pan. "Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review". Micromachines 14, nr 3 (26.02.2023): 547. http://dx.doi.org/10.3390/mi14030547.

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Microfluidics has recently received more and more attention in applications such as biomedical, chemical and medicine. With the development of microelectronics technology as well as material science in recent years, microfluidic devices have made great progress. Porous structures as a discontinuous medium in which the special flow phenomena of fluids lead to their potential and special applications in microfluidics offer a unique way to develop completely new microfluidic chips. In this article, we firstly introduce the fabrication methods for porous structures of different materials. Then, the physical effects of microfluid flow in porous media and their related physical models are discussed. Finally, the state-of-the-art porous microfluidic chips and their applications in biomedicine are summarized, and we present the current problems and future directions in this field.
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Chen, Pin Chuan, i Zhi Ping Wang. "A Rapid and Low Cost Manufacturing for Polymeric Microfluidic Devices". Advanced Materials Research 579 (październik 2012): 348–56. http://dx.doi.org/10.4028/www.scientific.net/amr.579.348.

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A rapid manufacturing process was demonstrated to fabricate a microfluidic device to amplify specific DNA fragments in less than 8 hours. Microfluidics was derived from microelectromechanical system (MEMS) with lithography technique on the substrates of silicon and glass, which made the microfluidic product have a higher fabrication cost and laborious fabrication steps. This rapid approach only requires three steps for a PDMS microfluidic device: metal mold insert manufacturing, PDMS casting, and glass bonding. Each step did not require complicated equipments or procedures, and make this approach very attractive in rapid prototyping and experimental optimization with microfluidic devices. In this work, a brass mold insert was manufactured by a micromilling machine, followed by the standard PDMS casting and glass bonding to fabricate a microfluidic device. Polymerase chain reaction (PCR) to amplify specific DNA fragments, a typical microfluidic example, was successfully realized on this PDMS microfluidic device. This rapid and low cost (compared to conventional lithography) fabrication approach can provide researchers a lower entry to polymeric lab-on-a-chip either on PDMS or thermoplastic substrate for various applications.
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Rozprawy doktorskie na temat "Microfluidic devices"

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Fiorini, Gina S. "Polymeric microfluidic devices : development of thermoset polyester microfluidic devices and use of poly(dimethylsiloxane) devices for droplet applications /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8627.

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Gallagher, Sarah. "Microfluidic confinement of responsive systems". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648567.

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Chen, Tian Lan. "Thermal digital microfluidic devices for rapid DNA analysis". Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3691869.

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Sun, Han. "Novel microfluidic platform for bioassays". HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/699.

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Microfluidics have been created to acquire, operate, and process complex fluids in extremely tiny volumes with high efficiency and high speed, and without the requirement for an experienced operator. In addition, microfluidic systems also enable miniaturization and incorporation of different complex functions, which can help bring intricate diagnostic tools out of the laboratories. Ideally, these systems should be inexpensive, precise, reliable, robust, and well-suited to the medical diagnostic systems. Most of the microfluidic devices reported previously were based on devices made of polydimethylsiloxane (PDMS). PDMS is a material that dissolves in many common organic solvents. Meanwhile, it is also prone to absorb small molecules like the proteins, which is detrimental to a stable and reliable result. Current work focuses on bioassays that are badly needed in our life and these bioassays are addressed based on microfluidic platform with different materials. The translation of microfluidic technology into large scale implementations highly relies on new materials that address the limitations of PDMS. Firstly, we fabricated two different microfluidic platforms for rapid antimicrobial susceptibility testing (AST). One was made of hydrogel, and the bacterial cells were cultured on the top of the device; the other was of polypropylene (PP), and bacterial cells were cultured inside the microchannels. Meanwhile, we developed a novel "barcode" sensor, a microscope-free method for cell accumulation and cell counting, as the downstream of the PP-based chips. As a result, AST can be accomplished simply through an application on a mobile phone rather than using an expensive and sophisticated microscope. Secondly, we presented a self-contained paper-based system for lead(II) ion detection based on G-quadruplex-based luminescence switch-on assay, comprising a novel type of paper-based chip and a matching portable device. Different from the reported paper-based devices, the paper substrate we chose was art paper, which is used for printing magazines. This type of paper could prevent the absorption of liquid into the paper matrix and hold the liquid in place for a period of time; and it could also be used for temporary liquid containing like a plastic substrate (such as polypropylene (PP) and polystyrene (PS)), but the surface of the paper is inherently hydrophilic. In such a design, liquid drops are suspended on the surface of the device in designed reservoirs, rather than absorbed into the paper; when the chip is tilted, the liquid drops will move to other reservoirs according to the guidance of channels defined on the surface. To differentiate it from reported μPAD devices that are fabricated with water-permeable paper, we name this new type of paper-based devices suspending-droplet mode paper-based microfluidic devices (SD-μPAD). Different from the conventional μPADs that use capillary force to drive liquid, our SD-μPADs uses wetting and gravity as driving force. To fabricate the superhydrophobic pattern on the paper device, we developed a new microcontact printing-based method to produce inexpensive and precisely patterned superhydrophobic coating on paper. The coating material is poly(dimethylsiloxane) (PDMS), a hydrophobic and transparent silicone that has long been used for fabricating microfluidic devices. Importantly, the negative-relief stamp we used is made of Teflon, a non-stick polymer, so that the PDMS-coated paper could be peeled from the stamp flawlessly. After such fabrication process, the stamped area of the paper is coated with a textured PDMS layer that is decorated with arrays of micropillars, which could provide superhydrophobic effect and most effectively hold the droplets in place; the remaining area of the paper is still hydrophilic. As a demonstration of this new design, we developed a method using the reaction characteristics of iridium(III) complex for rapid, onsite detection of lead(II) ions in liquid samples. As the reagents have already been loaded onto the paper device during fabrication, the only reagent the users need to add is water. Because of the large Stokes shift of the iridium(III) complex probe, inexpensive optical filters can be employed, and we were able to make an inexpensive, battery-powered compact device for routine portable detection using a smartphone as a detector, allowing the rapid analysis and interpretation of results on site as well as the automatic dissemination of data to professional institutes, including tests even in poor rural areas in developing countries. Thirdly, we upgraded our suspending-droplet mode paper-based microfluidic device (SD-μPAD), which is used for the detection of lead(II) ions in liquid solution. The reason is that our paper-based SD chips are not suitable for long reaction process (> 20 min) detection of biomolecules due to the potential permeation and contaminating problems of art papers. Hence, we chose polypropylene (PP), a hydrophobic, cheap, and thermal stable material (< 110°C), as the material for the fabrication of the SD microfluidic chip. We established a convenient, low-cost, portable and reliable platform for monitoring VEGF165 accurately, which can be applied for point-of-care (POC) testing. In this project, we also employed the label-free oligonucleotide-based luminescence switch-on assay on the microfluidic platform, which possesses the advantages of high sensitivity and high selectivity. Based on the detection of VEGF165 in a three-step reaction process, we adopted a new design for the droplet transfer throughout the channels. This design could migrate the droplet through the chambers via controlling the orientation of the chip, which systematically combined the superhydrophobic force of the coating, the gravity of the droplet and the surface tension between PP and droplet. Therefore, traditional micro pump could be avoided and the total cost for the device could be substantially reduced. In addition, we developed an automatic, matched and portable device for the detection of VEGF165, which assembled by a rotatable chip holder, a UV lamp, a filter, and a camera. Finally, we developed a new whole Teflon membrane-based chip for the aptamer screening. Our article "Whole-Teflon microfluidic chips" introduced the fabrication of a microfluidic device entirely using Teflon materials, one group of the most inert materials in the world. It was a successful and representative introduction of new materials into the fabrication of microfluidic devices, which show dramatically greater anti-fouling performance. However, even such device was inadequate for current purpose, as it is rigid and lacks convenient valve control functions for particle suspensions used in systematic evolution of ligands by exponential enrichment (SELEX). For this project, we propose a SMART screening strategy based on a highly integrated microfluidic chip. This new type of whole-Teflon devices, which are made of flexible Teflon membranes, offering convenient valving control for the whole SELEX process to be performed on chip and fulfilling the anti-fouling requirement in the meantime. The SELEX cycles including positive and negative selections could be automatically performed inside tiny-size microchambers on a microchip, and the enrichment is real-time monitored. The selection cycles would be ended after the resulted signal of the aptamers with high specificity reached a plateau, or no target aptamer is captured after a number of cycles of enrichment. Owning to the antifouling property of the chip materials, the loss of the sample is tremendously reduced. The SMART platform therefore is not only free of complicated manual operations, but also high-yield and well reproducible over conventional methods
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Fallahi, Hedieh. "Flexible and Stretchable Microfluidics". Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415361.

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Microfluidics is the science and technology of manipulating and analysing small amounts of liquid. Microfluidics has several advantages including small sample volume, small footprint, being cheap, portable, and precise. Microfluidics has applications in a wide range of areas such as in chemistry, electronics, and most importantly in biological sciences. Microfluidic functions are greatly influenced by the geometry and dimensions of the microchannels. The main challenge facing microfluidics is that once the conventional rigid microfluidic device is fabricated, its dimensions cannot be changed or modified. To overcome this problem, we proposed the concept of flexible and stretchable microfluidics. Stretchable microfluidics allows flexible devices to change their dimensions and thus enabling new functionalities. This thesis aims to (i) understand the fundamentals of flexible microfluidics, (ii) design and fabricate a new generation of stretchable microfluidic devices with tuneable dimensions, and (iii) apply stretchable microfluidics to three main handling tasks of separation mixing and trapping. Our main goal is to evaluate how the dimensions of different types of microfluidic devices alter under elongation and how these dimensional changes influence its functions. In this thesis, following a comprehensive introduction in chapter 1, a thorough literature review over flexible microfluidics is provided in chapter 2. The review covers three main areas of flexible microfluidics including materials, effect of flexibility on microfluidic functions, and the current applications and future perspectives of flexible microfluidics. Chapter 3 and 4 investigate the effect of stretchability on inertial microfluidics. Inertial microfluidics is a promising approach for particle separation. The current obstacle of inertial microfluidics in biological applications is the broad size distribution of biological microparticles. Rigid microfluidic devices work well for a narrow range of particle sizes. For focusing and separating a new set of particles, troublesome and time-consuming design, fabrication, testing, and optimization procedures are needed. Thus, a stretchable a microfluidic device with tuneable dimensions was fabricated and studied in chapter 3. By changing the channel dimensions under elongation, the device could be adapted to different particle sizes and flow rate ratios. Stretching the device significantly improved the focusing and separation efficiency of the specific particle sizes. In chapter 4, we focused on the application of stretchable inertial microfluidics for cancer detection. The performance of the stretchable device was verified by isolating cancer cells from WBCs and from whole blood with high recovery rates and purities. Chapter 5 studies the effect of stretchability on micromixing. A micromixer is an indispensable component in miniaturised platforms for chemical, biochemical, and biomedical applications. Mixing in microscale is challenging due to the laminar flow associated with low Reynolds numbers. This chapter reports a stretchable micromixer with dynamically tuneable channel dimensions. Periodic elongation of the stretchable micromixer results in mixing disturbance in intermediate Reynolds numbers. Periodically stretching the device changes the channel geometry and dimensions leading to dynamically evolving secondary and main flows. We evaluated the performance of this stretchable micromixer both experimentally and numerically. Chapter 6 reports a stretchable microtrapper. Microfluidic technologies have been widely used for single-cell trapping. However, there are no robust methods for the facile release of the captured cells for subsequent studies. Therefore, we developed a stretchable microfluidic cell trapper for easy on-demand release of cells in a deterministic manner. By tunning the horizontal elongation of the device, the gap at the bottom of the traps widened and provided ample space for releasing particle/cell with sizes of interest. The proposed stretchable micro trapper demonstrated a deterministic recovery of the captured cells by adjusting the elongation length of the device. Flexible and stretchable microfluidic devices with tuneable dimensions were introduced and studied extensively in this thesis. We showed that by applying stretchability to microfluidic functions including inertial microfluidics, micromixing, and single cell studies, several drawbacks associated with fixed dimensions were addressed and recovered. We believe that flexible and stretchable microfluidics is a new research direction of microfluidics.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environment and Sc
Science, Environment, Engineering and Technology
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Tsai, Long-Fang. "Microfluidic Devices and Biosensors". BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5821.

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My research broadly covers various important aspects of microfluidic devices and biosensors. Specifically, this dissertation reports: (1) a new and effective room temperature method of bonding polydimethylsiloxane (PDMS) microfluidics to substrates such as silicon and glass, (2) a new microfluidic pump concept and implementation specifically designed to repeatedly drive a small sample volume (<1 µL) very rapidly (~500 µL/min) through a sensor-containing flow channel to significantly decrease sensor response time through advection-driven rather than diffusion-driven mass transport, (3) use of a new microfluidic material based on polyethylene glycol diacrylate (PEGDA) to implement impedance-based dynamic nanochannel sensors for protein sensing, and (4) an investigation of galvanoluminescence and how to avoid it for conditions important to fluorescence-based dielectrophoresis (DEP) microfluidic biosensors. Over the last decade, the Nordin research group has developed a lab-on-a-chip (LOC) biosensor based on silicon photonic microcantilever arrays integrated with polydimethylsiloxane (PDMS) microfluidics for protein biomarker detection. Integration requires reliable bonding at room temperature with adequate bond strength between the PDMS element and microcantilever sensor substrate. The requirement for a room temperature process is particularly critical because microcantilevers must be individually functionalized with antibody-based receptor molecules prior to bonding and cannot withstand significant heating after functionalization. I developed a new room temperature bonding method using PDMS curing agent as an intermediate adhesive layer. Two curing agents (Sylgard 184 and 182) were compared, as well as an alternate UV curable adhesive (NOA 75). The bond strength of Sylgard 184 was found to be stronger than Sylgard 182 under the same curing conditions. Overnight room temperature curing with Sylgard 184 yields an average burst pressure of 433 kPa, which is more than adequate for many PDMS sensor devices. In contrast, UV curable epoxy required a 12 hour bake at 50 °C to achieve maximum bond strength, which resulted in a burst pressure of only 124 kPa. In many biosensing scenarios it is desirable to use a small sample volume (<1 µL) to detect small analyte concentrations in as short a time as possible. I report a new microfluidic pump to address this need, which we call a reflow pump. It is designed to rapidly pump a small sample volume back and forth in a flow channel. Ultimately, the flow channel would contain functionalized sensor surfaces. The rapid flow permits use of advection-driven mass transport to the sensor surfaces to dramatically reduce sensor response times compared to diffusion-based mass transport. Normally such rapid flow would have the effect of decreasing the fraction of analyte molecules in the volume that would see the sensor surfaces. By configuring the pump to reflow fluid back and forth in the flow channel, the analyte molecules in the small sample volume are used efficiently in that they have many opportunities to make it to the sensor surfaces. I describe a 3-layer PDMS reflow pump that pumps 300 nL of fluid at 500 µL/min for 15 psi actuation pressure, and demonstrate a new two-layer configuration that significantly simplifies pump fabrication. Impedance-based nanochannel sensors operate on the basis of capturing target molecules in nanochannels such that impedance through the nanochannels is increased. While simple in concept, the response time can be quite long (8~12 hours) because the achievable flow rate through a nanochannel is very limited. An approach to dramatically increase the flow rate is to form nanochannels only during impedance measurements, and otherwise have an array of nanotrenches on the surface of a conventional microfluidic flow channel where they are exposed to normal microfluidic flow rates. I have implemented such a dynamic nanochannel approach with a recently-developed microfluidic material based polyethylene glycol diacrylate (PEGDA). I present the design, fabrication, and testing of PEGDA dynamic nanochannel array sensors, and demonstrate an 11.2 % increase in nanochannel impedance when exposed to 7.2 µM bovine serum albumin (BSA) in phosphate buffered saline (PBS). Recently, LOC biosensors for cancer cell detection have been demonstrated based on a combination of dielectrophoresis (DEP) and fluorescence detection. For fluorescence detection it is critical to minimize other sources of light in the system. However, reported devices use a non-noble metal electrode, indium tin oxide (ITO), to take advantage of its optical transparency. Unfortunately, use of non-noble metal electrodes can result in galvanoluminescence (GL) in which the AC voltage applied to the electrodes to achieve DEP causes light emission, which can potentially confound the fluorescence measurement. I designed and fabricated two types of devices to examine and identify conditions that lead to GL. Based on my observations, I have developed a method to avoid GL that involves measuring the impedance spectrum of a DEP device and choosing an operating frequency in the resistive portion of the spectrum. I also measure the emission spectrum of twelve salt solutions, all of which exhibited broadband GL. Finally, I show that in addition to Au, Cr and Ni do not exhibit GL, are therefore potentially attractive as low cost DEP electrode materials.
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Li, Yi. "Membrane-Based Protein Preconcentration Microfluidic Devices". Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1216.pdf.

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Brotherton, C. M. "Mixing in polymeric microfluidic devices". Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3256449.

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England, Pinar. "Droplet behaviour in microfluidic devices". Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30138.

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This work is a study to understand the various aspects of a microfluidic device. In the first half we take the role of an end user, experimenting to learn how best to use the device efficiently. In the second half we are the manufacturer, trying to fabricate a user friendly, and fully functioning microfluidic device. As the end user, we have three different T-junction droplet generator devices, with similar geometries. We start investigating by generating water droplets in an oil medium. They self-organise into various flow patterns: single-profile, double-helix profile and triple-helix profile. We document how, with increasing flow rate ratio and capillary number, we observe more densely packed droplet flow patterns. The device with the deeper expansion channel provides more space for the droplets and they self-organise the triple-helix pattern in 3-dimension. We then use the same devices to generate droplets for which we can calculate the volume. The fluid flow in a microchannel happens in four different regimes: ballooning, squeezing, dripping and jetting regimes. In single-cell and single-molecule analysis devices, the ability to create droplets on demand and of a certain volume is a desired capability. This can be achieved by understanding and learning how to use the fluid flow characteristics accurately. We experiment with the three different sized microfluidic devices, to measure the droplet volume throughout the squeezing to dripping regimes. This is achieved by manipulating the capillary number and the flow rate ratio. We observe a similar result as with the flow patterns: that the capillary number has an impact on the droplet volume. As the capillary number increases the droplet diameter decreases. Further, for a set capillary number we can fine tune the droplet diameter by changing the flow rate ratio. As the flow rate ratio increases the volume of water droplets increases, despite the fact the capillary number is set. These coincide with our flow pattern results. Our results fit to the scaling law to predict the droplet size introduced by Tanet al. in 2008 [51]. Unlike some other authors in the literature, we did not observe a critical capillary number where the droplet volume changes suddenly. However, we did observe a transition area where we cannot define the regime of the fluid flow. As the manufacturer we designed and fabricated our own planar free standing microfluidic devices using a polymer called SU-8. After looking into the weaknesses and the strengths of using SU-8, we describe how we successfully fabricated working devices and developeda new procedure in adhesive low temperature bonding. We finish by considering the challenges of connecting micro sized structures to a macro sized syringe pump, and fabricated a chip-holder inspired by applications in industry.
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Sun, Xuefei. "Polymeric microfluidic devices for bioanalysis /". Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd2785.pdf.

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Książki na temat "Microfluidic devices"

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Angelescu, Dan E. Highly integrated microfluidics design. Boston: Artech House, 2011.

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Kumar, Challa S., red. Microfluidic Devices in Nanotechnology. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470622551.

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Kumar, Challa S., red. Microfluidic Devices in Nanotechnology. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470622636.

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Kumar, C. S. S. R., red. Microfluidic devices in nanotechnology. Hoboken, N.J: Wiley, 2010.

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Kumar, C. S. S. R., red. Microfluidic devices in nanotechnology. Hoboken, N.J: Wiley, 2010.

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Kirby, Brian. Micro- and nanoscale fluid mechanics: Transport in microfluidic devices. New York: Cambridge University Press, 2010.

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Wei na liu kong xin pian shi yan shi. Beijing Shi: Ke xue chu ban she, 2013.

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Li, Xiujun, i Zhou Yu. Microfluidic devices for biomedical applications. Cambridge, UK: Woodhead Publishing, 2013.

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Kumar, C. S. S. R. Microfluidic devices in nanotechnology: Applications. Hoboken, N.J: Wiley, 2010.

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C. S. S. R. Kumar. Microfluidic devices in nanotechnology: Applications. Hoboken, N.J: Wiley, 2010.

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Części książek na temat "Microfluidic devices"

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Cetin, Barbaros, Soheila Zeinali i Dongqing Li. "Microfluidic Optical Devices". W Encyclopedia of Microfluidics and Nanofluidics, 1980–84. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_940.

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Cetin, Barbaros, Soheila Zeinali i Dongqing Li. "Microfluidic Optical Devices". W Encyclopedia of Microfluidics and Nanofluidics, 1–6. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-3-642-27758-0_940-6.

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Kjeang, Erik. "Devices". W Microfluidic Fuel Cells and Batteries, 25–49. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06346-1_4.

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Capretto, Lorenzo, Wei Cheng, Martyn Hill i Xunli Zhang. "Micromixing Within Microfluidic Devices". W Microfluidics, 27–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/128_2011_150.

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Zhu, Weiming, i Ai-Qun Liu. "Microfluidic Metasurfaces". W Metasurfaces: Towards Tunable and Reconfigurable Meta-devices, 35–50. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-6925-6_3.

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Le Gac, Séverine, i Iris van Uitert. "Electroporation in Microfluidic Devices". W Handbook of Electroporation, 1–20. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26779-1_136-1.

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Leester-Schädel, M., T. Lorenz, F. Jürgens i C. Richter. "Fabrication of Microfluidic Devices". W Microsystems for Pharmatechnology, 23–57. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26920-7_2.

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Miller, Elizabeth M. "Proteomics in Microfluidic Devices". W Encyclopedia of Microfluidics and Nanofluidics, 2884–95. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1311.

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Fletcher, David F., Brian S. Haynes, Joëlle Aubin i Catherine Xuereb. "Modeling of Microfluidic Devices". W Micro Process Engineering, 117–44. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527631445.ch5.

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Bishop, Gregory W. "3D Printed Microfluidic Devices". W Microfluidics for Biologists, 103–13. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40036-5_4.

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Streszczenia konferencji na temat "Microfluidic devices"

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Gao, Z., i K. Ng. "Fluid Dynamics of Microfluidic Devices". W ASME 2011 9th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2011. http://dx.doi.org/10.1115/icnmm2011-58285.

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The subject of fluid dynamics of microfluidic devices such as instability, droplet formation, and control has gained considerable momentum in recently years. This is due partially to the fact that modern developments in the design and utilization of microfluidic devices for fluid transport have found many applications such as drug design and diagnostic devices in biomedicine and microdrop generators for image printing. Furthermore, the new development of nonlinear dynamics of droplets has created a new paradigm of scaling and instability theory that opened a new approach to this classic phenomenon. The utility of a microfluidic device is linked directly to its ability to control microdroplets in precision and speed for desired functionalities. An example of such a device is Kodak’s Continuous Inkjet System, which is capable of stimulating drop breakup of jets of complex fluids with unprecedented precision, speed, and selectivity. We will utilize such a microfluidic device to discuss some of the fluid dynamics topics in microfluidic devices, and to illustrate that the fluid dynamic behavior of such a device is not only influenced by the device architecture, but also by the fluidic properties and by the way the fluid is energized to induce the drop formation and movement. The topics will include a discussion of fluid properties relative to jet modulation, wavelength dependencies, thermal modulation schemes, satellite drop formation, and aerodynamic effects.
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Zeng, Jun. "Electrohydrodynamic Modeling for Microfluidic Devices". W ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-10634.

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Since the inception of microfluidics, the electric force has been exploited as one of the leading mechanisms for driving and controlling the movement of the operating fluid (electrohydrodynamics) and the charged suspensions (electrokinetics). Electric force has an intrinsic advantage in miniaturized devices. Because the electrodes are placed cross a small distance, from sub-millimeter to a few microns, a very high electric field is rather easy to obtain. The electric force can be highly localized with its strength rapidly decaying away from the peak. This makes the electric force an ideal candidate for spatial precision control. The geometry and placement of the electrodes can be used to design electric fields of varying distributions, which can be readily realized by MEMS fabrication methods. In this paper we examine several electrically driven liquid handling operations. We discuss the theoretical treatment and related numerical methods. Modeling and simulations are used to unveil the associated electrohydrodynamic phenomena. The modeling based investigation is interwoven with examples of microfluidic devices to illustrate the applications. This paper focuses on detailed physical simulations of component-level operations. Since the components must be integrated to form a functional system in order to provide desired services, system-level complexities in both architecture and execution also need to be addressed. Compared to the state of the art of computer-aided design for microelectronics, the modeling aid for microfluidics systems design and integration is far less mature and presents a significant challenge, thus an opportunity for the microfluidics research community.
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Gao, Z., K. Ng, E. Furlani, J. Chwalek i G. Hawkins. "MEMS-Based Microfluidic Devices". W ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30020.

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Micro-Electro-Mechanical Systems (MEMS) technology can be integrated with microfluidic functionality to enable the generation of microdrops with unprecedented throughput and precise control of drop volume, speed, and placement. The most prominent examples of microdrop generators are in the field of inkjet printing where printheads with thousands of nozzles produce steady streams of microdrops at kilohertz repetition rates. In this paper, we discuss a proposed MEMS-based microfluidic drop generator that operates on the basis of a thermally induced Marangoni effect. We describe the physics of droplet generation and discuss operating performance relative to the fluid rheology, thermal modulation, and wavelength dependencies.
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Yuen, Po Ki, i Michael E. DeRosa. "Flexible Microfluidic Devices With Three-Dimensional Interconnected Microporous Walls". W ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-63758.

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Microfluidics is emerging as one of the fastest growing fields for chemical and biological applications. The demand has also increased for methods of fabricating low-cost prototype microfluidic devices rapidly with compatible materials and novel functional attributes. One attractive feature that can be incorporated into microfluidic devices is a porous membrane or porous channel wall [1]. Devices with such features can potentially be used for multiphase catalytic reactions in chemical and pharmaceutical applications similar to the gas-liquid-solid hydrogenation reactions reported by Kobayahi et al. [2] or gas-liquid syntheses by Park and Kim [3].
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Brinatti Vazquez, Guillermo D., Oscar E. Martinez i Juan M. Cabaleiro. "Confocal Raman thermometer for microfluidic devices". W Microfluidics, BioMEMS, and Medical Microsystems XVII, redaktorzy Bonnie L. Gray i Holger Becker. SPIE, 2019. http://dx.doi.org/10.1117/12.2508889.

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Xu, Wei, Hong Xue, Mark Bachman i Guann-Pynn Li. "Virtual Valve for Microfluidics". W ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38070.

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Lab-on-a-Chip technology now becomes increasingly attractive due to advantages such as reduced sample size, reduced reagent consumption, shortened analysis time, potential for high throughput and automation and reduced costs, leading to the potential for manufacturing of disposable devices. On such microchip system, the ability to handling microfluid is important. Extensive microfluidic handling componets including microflow regulator, microfluidic sensor, microvalve and micropump have been reported. Although these microfluid handling methods are successful, for the polymer based microfluidic device, a simple design, easy fabrication and the ability to integrate into the microsystem lacks report. In this paper, we presented such microvalve by utilizing the hydrophobicity of the PDMS material, a popular biocompatible material widely used in microfluidic system. The valve utilized air trapped on the side wall of microchannel by a special microconcave structure design. Controlled by an external coil heater, the trapped air will be enlarged to reduce channel width and so reduce the fluid flow in the microchannel. The valve can work in on/off mode or on flow regulating mode depending on specific flow control requirement.
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Dunning, Peter D., Pierre E. Sullivan i Michael J. Schertzer. "Method for Characterization of Passive Mechanical Filtration of Particles in Digital Microfluidic Devices". W ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38875.

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The ability to remove unbound biological material from a reaction site has applications in many biological protocols, such as those used to detect pathogens and biomarkers. One specific application where washing is critical is the Enzyme-Linked ImmunoSorbent Assay (ELISA). This protocol requires multiple washing steps to remove multiple reagents from a reaction site. Previous work has suggested that a passive mechanical comb filter can be used to wash particles in digital microfluidic devices. A method for the characterization of passive mechanical filtration of particles in Digital MicroFluidic (DMF) devices is presented in this work. In recent years there has been increased development of Lab-On-A-Chip (LOAC) devices for the automation and miniaturization of biological protocols. One platform for further research is in digital microfluidics. A digital microfluidic device can control the movement of pico-to nanoliter droplets of fluid using electrical signals without the use of pumps, valves, and channels. As such, fluidic pathways are not hardwired and the path of each droplet can be easily reconfigured. This is advantageous in biological protocols requiring the use of multiple reagents. Fabrication of these devices is relatively straight forward, since fluid manipulation is possible without the use of complex components. This work presents a method to characterize the performance of a digital microfluidic device using passive mechanical supernatant dilution via image analysis using a low cost vision system. The primary metric for performance of the device is particle retention after multiple passes through the filter. Repeatability of the process will be examined by characterizing performance of multiple devices using the same filter geometry. Qualitative data on repeatability and effectiveness of the dilution technique will also be attained by observing the ease with which the droplet disengages from the filter and by measuring the quantity of fluid trapped on the filter after each filtration step.
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Hashim, Uda, P. N. A. Diyana i Tijjani Adam. "Numerical simulation of Microfluidic devices". W 2012 10th IEEE International Conference on Semiconductor Electronics (ICSE). IEEE, 2012. http://dx.doi.org/10.1109/smelec.2012.6417083.

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Wille, Robert, Bing Li, Rolf Drechsler i Ulf Schlichtmann. "Automatic Design of Microfluidic Devices". W 2018 Forum on specification & Design Languages (FDL). IEEE, 2018. http://dx.doi.org/10.1109/fdl.2018.8524091.

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Aristone, Flavio, Proyag Datta, Yohannes M. Desta, Alexey M. Espindola i Jost Goettert. "Molded multilevel modular microfluidic devices". W Micromachining and Microfabrication, redaktorzy Holger Becker i Peter Woias. SPIE, 2003. http://dx.doi.org/10.1117/12.472890.

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Raporty organizacyjne na temat "Microfluidic devices"

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Schunk, Peter Randall, Amy Cha-Tien Sun, Robert H. Davis i Christopher M. Brotherton. Mixing in polymeric microfluidic devices. Office of Scientific and Technical Information (OSTI), kwiecień 2006. http://dx.doi.org/10.2172/892761.

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Schunk, Peter Randall, Amy Cha-Tien Sun, Robert H. Davis i Christopher M. Brotherton. Mixing in polymeric microfluidic devices. Office of Scientific and Technical Information (OSTI), wrzesień 2006. http://dx.doi.org/10.2172/893155.

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Sohn, Lydia L., David Beebe i Daniel Notterman. Electronic Sensing for Microfluidic Devices. Fort Belvoir, VA: Defense Technical Information Center, październik 2005. http://dx.doi.org/10.21236/ada455539.

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Barrett, Louise Mary, Renee Shediac i David S. Reichmuth. Diffusionless fluid transport and routing using novel microfluidic devices. Office of Scientific and Technical Information (OSTI), listopad 2006. http://dx.doi.org/10.2172/966249.

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Pier, Rose Angeli C., i Rebecca M. Chamberlin. Liquid-Liquid Extraction of Iron in Hydrochloric Acid with Quaternary Amines in Microfluidic Devices. Office of Scientific and Technical Information (OSTI), sierpień 2018. http://dx.doi.org/10.2172/1467377.

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Finneran, Kevin, Charles Werth i Timothy Strathmann. Final Project Report, DE-SC0001280, Characterizing the Combined Roles of Iron and Transverse Mixing on Uranium Bioremediation in Groundwater using Microfluidic Devices. Office of Scientific and Technical Information (OSTI), styczeń 2015. http://dx.doi.org/10.2172/1167119.

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Nguyen, Thanh Phong. Integrated Microfluidic Device for Real-Time: Reservoir Fluid Analysis. Office of Scientific and Technical Information (OSTI), lipiec 2018. http://dx.doi.org/10.2172/1459859.

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James, Conrad D., Patrick Sean Finnegan i Ronald F. Renzi. Reflected beam illumination microscopy using a microfluidics device (Progress report). Office of Scientific and Technical Information (OSTI), czerwiec 2014. http://dx.doi.org/10.2172/1171452.

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Kumar, Rajan. Microfluidic Flow Retardation Device for Tagless Cancer Cell Analysis for Metastatic Potential. Fort Belvoir, VA: Defense Technical Information Center, lipiec 2012. http://dx.doi.org/10.21236/ada566934.

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Saadi, Wajeeh M., i Noo L. Jeon. Develpment of a Microfluidic Device for the Study of Breast Cancer Cell Migration. Fort Belvoir, VA: Defense Technical Information Center, wrzesień 2005. http://dx.doi.org/10.21236/ada446737.

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