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Weber, Lloyd E. "The illicit methamphetamine landscape of Franklin County, Missouri application and analysis of a GIS-based risk assessment model /". Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4513.
Pełny tekst źródłaThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 21, 2009.) Includes bibliographical references.
Chen, Chih-Ken. "Predisposing factors to methamphetamine psychosis". Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274936.
Pełny tekst źródłaCotton, Sarah May. "Executive functioning in methamphetamine psychosis". Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/8714.
Pełny tekst źródłaAn association between methamphetamine dependence and neurocognitive impairment has long been established. However, there are a number of research gaps. First, while evidence suggests that the primary cognitive domains affected in methamphetamine dependence are executive functions; previous research fails to employ a comprehensive battery of executive functioning tests. Second, there is little research investigating the specific neuropsychological impairments associated with methamphetamine psychosis in particular. Third, ADHD is highly co-morbid with substance dependence. Symptoms of ADHD were therefore investigated as possible confounders in this study. Fourth, few studies of methamphetamine dependence have explored relationships between neuropsychological data and cortical thickness data; the current study therefore investigated this further. The current study employed a neuropsychological test battery to compare executive functioning across three groups; a methamphetamine dependent group without psychosis (n = 20), a methamphetamine dependent group with psychosis (n =19) and a healthy control group (n = 20); demographically matched. Brain images were acquired using a Siemens Magnetom Allegra 3T system with a high-resolution, T1-weighted, 3D-multiecho MPRAGE sequence with the following scan parameters: TR=2530ms; graded TE=1.53, 3.21, 4.89, 6.57ms; flip angle=7°; FOV=256mm; slice thickness=1mm; 160 slices; and acquisition duration of 10.49 min. Cortical thickness was assessed employing a surface-based cortical reconstruction and automatic labelling tool in the FreeSurfer software package. Four executive domains were identified and evaluated, namely decision making and impulsivity; inhibitory control and setshifting; attention and working memory; and verbal fluency. One-way ANOVAs were conducted in order to assess differences between groups. Analyses indicated significant between group differences on most tasks of executive functioning. Overall the methamphetamine psychosis (MA+) group performed more poorly than the methamphetamine non-psychosis (MA-) group and the controls (NC). Statistically significant between-group differences were observed on inhibitory control and set-shifting (p < .001), attention and working memory (p = .006), and on tasks of generativity (p < .001). Spearman's correlational analyses revealed that in general, executive impairment was associated with cortical thinning of frontal regions in the MA+ group and cortical thickening of frontal regions in the MA- group. This may be reflective of a compensatory response to methamphetamine toxicity in the MA- group. In conclusion, executive functioning was significantly impaired in the MA- group and even more so in the MA+ group. Symptoms of ADHD were not found to be significantly correlated with executive functioning data. Therefore executive dysfunction is more likely the result of MA toxicity than a pre-existing ADHD disorder. An improved understanding of the neuropsychology and neuroanatomy of methamphetamine dependence may ultimately contribute to the clinical management of these individuals.
Halpin, Laura E. "The Contribution of Ammonia to Methamphetamine Neurotoxicity". University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1370868834.
Pełny tekst źródłaHerring, Nicole Reneé. "Effects of Methamphetamine in the Adult Rat". University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1187007484.
Pełny tekst źródłaHerring, Nicole Renee. "Effects of Methamphetamine in the Adult Rat". Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc//view?acc_num=ucin1187007484.
Pełny tekst źródłaAdvisor: Dr. Michael T. Williams PhD (Committee Chair), Charles V. Vorhees PhD, Ton J. Degrauw MD, PhD, Kim B. Seroogy PhD, Gary A. Gudelsky PhD. Title from electronic thesis title page (viewed Mar. 28, 2009). Keywords: Methamphetamine; Path Integration; Spatial Navigation; Corticosterone; Adrenalectomy. Includes abstract. Includes bibliographical references.
Lapworth, Kely Narelle. "An Investigation of Aggression in Methamphetamine Users". Thesis, Griffith University, 2011. http://hdl.handle.net/10072/366564.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Psychology
Griffith Health
Full Text
Kennedy, Kelsey Marie. "The Relapse Cycles of Female Methamphetamine Users". Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579257.
Pełny tekst źródłaWeeden, Christy Samantha Star. "Neuroprotective Potential of Methamphetamine: Behavioral and Histological Analysis". Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/weeden/WeedenC0507.pdf.
Pełny tekst źródłaLowther, Courtney. "The Acute, Chronic, and Teratological Effects of Methamphetamine on Aggressive Behaviour in Adolescent Hooded Rats". Thesis, University of Canterbury. Psychology, 2012. http://hdl.handle.net/10092/7044.
Pełny tekst źródłaRocha, Angelica. "Methamphetamine self-administration in rats developmentally exposed to lead". [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1370.
Pełny tekst źródłaHagen, Gawie. "The impact of methamphetamine (tik) use on the workplace". Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/14622.
Pełny tekst źródłaENGLISH ABSTRACT: There has been a dramatic increase in the use of the drug methamphetamine, also known locally as tik, in the Western Cape, specifically in Cape Town. This trend impacts the availability and the quality of labour as well as the productivity of current employees. The presence of tik abuse in the workplace represents both legal and ethical challenges to employers. The Labour Relations Act of 1995 states that employers must ensure a safe working environment for their employees. The actions of tik users tend to increase the risk of injuries at work and the occurrences of workrelated accidents that may harm others. Social responsibility requires employers to operate their business in an honourable manner, to provide good working conditions and to work actively to better the quality of life of the local communities where it operates. This responsibility translates into helping the tik users that they employ. The current relationship between employer and employee regarding tik is marred by conflict and misunderstanding. Employers seem unsure what to do and are unaware of how far-reaching tik abuse is. Tik abuse causes many problems for employees and also for their family and friends. By gathering information in a structured way the study aims to improve the understanding of employers so that they can help and prevent tik-related problems in the future. The study utilized descriptive qualitative research in the form of a questionnaire given to recovering tik users at two treatment centres in Cape Town, SANCA and De Novo. The research ran for about a month and gathered 82 usable questionnaires. Results, along with a literature study, were used to create a framework to guide employers on identifying tik users and on how to deal with them. The framework, the Tik Identification and Intervention Protocol (TIIP), contains criteria to help identify employees that may be using tik. The study showed that many international trends are evident in Cape Town. Approximately 40% of participants indicated that they were absent from work more often than prescribed by labour legislation; 70% of participants experienced that tik affected their ability to perform their duties; 32% of participants admitted that they stole to obtain funding for their drug habit. Some new findings became evident, such as the impact of the family on the participant's decision to go for treatment. The Western Cape's treatment centres are severely hampered by a lack of resources and are incapable at present of dealing with the current flood of patients. While plans are in place to rectify this, it is clear that in the short term at least, employers will have to take up more of the slack. The recovery process for a drug addict takes a long time; experts suggest it may take up to two years. Therefore employers need to be involved and create support programs at work to assist employees in their recovery. Employees can be cured from their dependency on tik, so that they can become healthy and contribute to the community and to their employer.
AFRIKAANSE OPSOMMING: Daar is 'n dramatiese toename in die voorkoms en gebruik van metaphetamien (plaaslik bekend as tik) in die Wes-Kaap, spesifiek in Kaapstad. Die tendens het 'n impak op die verskaffing en die kwaliteit van beskikbare arbeid, sowel as die produktiwiteit van huidige werknemers. Die voorkoms en gebruik van tik in die werksplek het beide wetlike en etiese uitdagings vir werkgewers. Die Arbeidswet van 1995 verklaar dat die werkgewer daarvoor verantwoordelik is om te verseker dat hul werksplek veilig is vir hul werknemers. Tik gebruikers verhoog die risiko en die voorkoms van werksbeserings en werksongelukke wat ander werknemers ook mag beinvloed. Sosiale verantwoordelikheid vereis van werkgewers om hul besighede op 'n eerbare wyse te bestuur, om goeie werksomstandighede te verseker en 'n aktiewe bedrae te lewer in die plaaslike gemeenskap waar hulle hul ook mag bevind. Die verantwoordelikheid sluit tik gebruikers in. Die huidige verhouding tussen werkgewers en werknemers in verband met die misbruik van tik word gekenmerk deur konflik. Werkgewers blyk onseker te wees ten opsigte van wat hul te doen staan en hoe verreikend die impak van die misbruik van tik mag wees. Die misbruik van tik veroorsaak 'n menigte probleme vir werknemers, sowel as vir hul vriende en families. Hierdie studie poog am deur 'n gestruktureerde wyse informasie te versamel met die doel om die begrip van werkgewers te verbeter, sodat hul tik gebruikers kan help en tik-verwante probleme in die toekoms kan voorkom. Die studie is beskrywend kwalitatief van aard en gebruik 'n vraelys om informasie te versamel by twee behandelingsentrums in Kaapstad, SANCA en De Novo. Die navorsing het vir omtrent 'n maand geduur waarna 82 bruikbare vraelyste ingewin is. Die resultate, sowel as die literatuurstudie wat gedoen is, is gebruik om 'n raamwerk op te stel wat werkgewers kan help om tik gebruikers te identifiseer, sowel as hoe om hulle te ondersteun. Die eerste gedeelte van die raamwerk, die Tik Identifikasie en Ingrypings Protokol (TIIP), bestaan uit kriteria wat gebruik kan word om werknemers te identifiseer wat tik gebruik. Hierdie studie het gewys dat verskeie internasionale tendense sigbaar is in Kaapstad. Ongeveer 40% van die deelnemers het aangewys dat hulle meer as die wetlike hoeveelheid dae afwesig was van die werk, 70% van die deelnemers het erken dat tik hulle vermoe am hul werk behoorlik te kan doen beinvloed het en 32% van die deelnemers het erken dat hulle gesteel het om geld te verkry am tik te koop. Die studie het daarop gedui dat die familie 'n integrale rol gespeel het in die deelnemers se besluit om vir behandeling te gaan. Dit blyk dat die Wes-Kaapse behandelings-hulpbronne ver te kort skiet om die saak te hanteer. Daar is tans planne in plek am die probleem die hoof te bied, maar dit is duidelik dat in die korttermyn, werkgewers 'n groter rol sal moet speel. Die herstelproses is van lange duur, en kenners meen dat dit tot twee jaar mag neem voor tik gebruikers volkome herstel het. Die werkemers het ondersteuning nodig gedurende hierdie moeilike proses. Die studie het bevind dat werknemers herstel en gesond kan word om weer 'n bydrae te kan lewer vir beide die werkgewer en die bree samelewing.
Thrash, Bessy Suppiramaniam Vishnu Dhanasekaran Muralikrishnan. "Neuroprotection against methamphetamine induced neurotoxicity applications for Parkinson's disease /". Auburn, Ala, 2009. http://hdl.handle.net/10415/1718.
Pełny tekst źródłaKing, Kristine M. "An evaluation of a methamphetamine intervention on drug markets". abstract and full text PDF (UNR users only), 2009. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1464445.
Pełny tekst źródłaZabida, Omer Saleh. "The effect of methamphetamine on the blood-testis barrier". University of the Western Cape, 2018. http://hdl.handle.net/11394/6775.
Pełny tekst źródłaIntroduction The blood-testis barrier (BTB) is formed by tight junctions between adjacent Sertoli cells. The barrier formed by these tight junction helps to create a specialized environment for spermatogenesis and provide an immunological barrier to protect developing germ cells. Methamphetamine (Meth) is known as neurotoxin however, its effects on the male reproductive system, especially on Sertoli cells and, the BTB are not well established. Therefore, this study aimed to determine the effects of Meth on the TM4 mouse testis Sertoli cell line and on the integrity of the BTB permeability. Materials and Methods This study investigated the effect of selected concentrations of Meth (0.1 μM, 1 μM, 10 μM, 20 μM and 100 μM) on TM4 mouse testis Sertoli cell line for 24 until 96 hours, using two treatments: an “acute” study (24 hrs exposure) and a “chronic” study, where treatment occurred on a daily basis over 96 hrs. The following parameters were investigated: viability, cell proliferation, mitochondrial activity, monolayer permeability.
Brown, Stacy D. "Methods for Confirmatory Analysis of Methamphetamine in Biological Samples". Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/5333.
Pełny tekst źródłaSwanke, Jayme Rae. "EMPLOYED VS UNEMPLOYED METHAMPHETAMINE USERS: SPECIFIC IMPLICATIONS FOR CASE MANAGERS". OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/109.
Pełny tekst źródłaRoussell, Aaron. "Wyoming ice social disorganization and methamphetamine use in a rural state /". Laramie, Wyo. : University of Wyoming, 2007. http://proquest.umi.com/pqdweb?did=1317343901&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Pełny tekst źródłaSwanke, Jayme R. "Employed vs unemployed methamphetamine users : specific implications for case managers /". Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1968461061&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Pełny tekst źródłaClavenstam, Isabell. "The Effect of Methamphetamine Abuse on Brain Structure and Function". Thesis, University of Skövde, School of Humanities and Informatics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3106.
Pełny tekst źródłaThe great amount of METH abuse all over the world causes enormous social and criminal justice problems. In the human brain the abuse of METH causes implications on both structures and functions given rise to acute as well as long term symptoms. In this essay the effects of METH abuse is described in the manner of the drug mechanism such as the impact on neurotransmitters, structural deficits with decreased and increased volumes and the implication on attention, memory, decision making and emotions. Results from studies showing brain structural and cognitive impairments in METH abusers and in prenatal METH exposed children.
Kalula, Asha Saidi. "Modelling the dynamics of methamphetamine abuse in the Western Cape". Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6817.
Pełny tekst źródłaIncludes bibliography
ENGLISH ABSTRACT: The production and abuse of methamphetamine has increased dramatically in South Africa, especially in the Western Cape province. A typical methamphetamine use cycle consists of concealed use after initiation, addiction, treatment and recovery. The model by Nyabadza and Musekwa in [32], is extended to include a core group, fast and slow progression to addiction. The model is analysed analytically and numerically using mass action incidence function and non-linear incidence function. The analysis of the model with mass action incidence is presented in terms of the methamphetamine epidemic threshold R0. The analysis shows that the drug free equilibrium is locally asymptotically stable when R0 < 1 and drug persistent equilibrium is locally asymptotically stable when R0 > 1. The model also exhibits a backward bifurcation. Sensitivity analysis of the model on R0 is performed. The most sensitive parameters are transmission rate and recruitment rate of individuals into the core group. The non-linear incidence incorporates innovators and behaviour change. Analytically, the model is analysed in the absence of behaviour change. With behaviour change two cases were considered. Firstly without innovators and secondly with innovators. In the absence of innovators the non-linear incidence reduced to standard incidence and similar results to the ones in the first model were obtained. With the presence of innovators there is no drug free equilibrium. Numerically we fit the model to data on the number of patients who enter into treatment centers for rehabilitation. Using the fitted model, we determine the prevalence and incidence of methamphetamine abuse. We investigate the impact of behaviour change, ‘reinfection’ rate as well as uptake rate into treatment on prevalence. Our results suggest that intervention and prevention programs focusing on behaviour change and uptake rate into treatment would reduce the prevalence. Projections are made to determine the possible long term trends of the prevalence of methamphetamine abuse in the Western Cape. We give suggestions related to data that should be collected from a modelling perspective.
AFRIKAANSE OPSOMMING: Die vervaardiging en misbruik van metamfetamien het dramaties in Suid-Afrika toegeneem, veral in die Wes-Kaap provinsie. ’n Tipiese metamfetamien gebruiksiklus bestaan uit heimlike gebruik na aanvang, verslawing, behandeling en herstel. Die model deur Nyabadza en Musekwa in [32], is uitgebrei om ’n kerngroep in te sluit, vinnige en stadige verloop tot verslawing. Die model is analities en numeries ontleed deur van massa-aksie insidensie funksie en ’n nie-liniêre insidensie funksie gebruik te maak. Die ontleding van die model met massa-aksie insidensie word voorgestel in terme van die metamfetamien epidemiese drempel R0. Die ontleding toon dat die dwelmvrye ewewig lokaal asimptoties stabiel is as R0 < 1 en die dwelmblydende ewewig is lokaal asimptoties stabiel as R0 > 1. Die model beeld ook ’n terugwaartse bifurkasie uit. Sensitiwiteitsontleding van die model ten opsigte van R0 is uitgevoer. Die mees sensitiewe parameters is die oordraagbaarheidskoers en die rekrute koers van individue in die kerngroep in. Die nuwelinge en gedragsverandering word deur die nie-liniêre insidensie opgeneem. Analities, is die model ontleed in die afwesigheid van gedragsverandering. Met gedragsverandering is twee gevalle beskou. Eerstens sonder nuwelinge en tweedens met nuwelinge. In die afwesigheid van nuwelinge is die nie-liniêre insidensie herlei tot standaard insidensie en soortgelyke resultate is verkry, as dié wat in die eerste model verkry is. Met die aanwesigheid van nuwelinge is daar geen dwelmvrye ewewig nie. Numeries pas ons die model aan die data wat betrekking het met die aantal pasiënte wat in rehabilitasie sentra opgeneem word vir behandeling. Deur die gepaste model te gebruik, het ons die voorkoms en insidensie van metamfetamien misbruik bepaal. Ons ondersoek die impak van gedragsverandering, “re-infeksie” koers sowel as die koers van opname in behandeling op voorkoms. Ons resultate toon dat intervensie- en voorkomingsprogramme sal voorkoms verlaag, wat op die gedragsverandering en die koers van opname in behandeling konsentreer. Die model is ook gebruik om die aantal metamfetamien gebruikers te projekteer. Ons maak voorstelle verwant aan die data, wat vanuit ‘n modellerings-oogpunt ingesamel moet word.
Linnemann, Travis. "Beyond the ghetto: methamphetamine and the punishment of rural America". Diss., Kansas State University, 2011. http://hdl.handle.net/2097/12021.
Pełny tekst źródłaDepartment of Sociology, Anthropology, and Social Work
L. Susan Williams
Since the early 1970s, the United States has grown increasingly reliant on the criminal justice system to manage a wide array of social problems. Aggressive drug control policies and an over-reliance on imprisonment helped produce the world’s largest prison and correctional population, often described as mass imprisonment. Within this context, the study provides an explanatory account of the political, cultural, and social conditions that encourage states like Kansas to pursue methamphetamine as a major public concern, and to a greater degree than other states with relatively higher meth problems. Ultimately, and most important, the study makes a theoretical contribution by demonstrating how meth control efforts, analogous to previous drug control campaigns, extends punitive drug control rationalities to new cultural contexts and social terrains beyond the so-called ghetto of the inner city, thereby reinforcing and extending the logics of mass imprisonment.
Darsamo, Arnalda Vanessa. "The societal costs of methamphetamine use in Western Cape Province". Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20849.
Pełny tekst źródłaLederer, Katharina Johanna. "Relationship between white matter changes and aggression in methamphetamine dependence". Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/13802.
Pełny tekst źródłaMoodley, Aneshree. "Methamphetamine use and HIV risk among severely mentally ill inpatients". Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/10989.
Pełny tekst źródłaSub-Saharan Africa accounts for 69% of the global HIV burden. Due to a variety of social, economic and behavioural factors, mentally ill patients are more likely to engage in high risk sexual behaviours. In turn, co-morbid substance use which is present in up to 75% of mentally ill patients is a leading risk factor for sexual risk behaviours. Worldwide methamphetamines are the most commonly used illicit stimulant. Both injectable and noninjectable methamphetamines have evidenced associations with high risk sexual behaviours. Smoking and inhalation of crystal methamphetamine is the predominant mode of use in South Africa. The use of crystal methamphetamine amongst mentally ill persons in Cape Town has escalated over the last decade. We aimed to determine the occurrence of methamphetamine use and risky sexual practices amongst mentally ill patients. In addition we aimed to explore the associations between methamphetamine use and HIV sexual risk behaviours in a sample of mentally ill inpatients in Cape Town, South Africa.
Alshehri, Fahad. "Role of Glutamate Transporters in Alcohol and Methamphetamine Co-Abuse". University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1433195506.
Pełny tekst źródłaGutierrez, Arnold. "The role of dopamine receptors in methamphetamine-induced cognitive deficits". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521189209471948.
Pełny tekst źródłaBaicy, Kate. "Dissociation between neural processing and negative emotion in methamphetamine dependence". Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1666904001&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Pełny tekst źródłaJackson, Brian Joshua. "Cognitive function and excessive daytime sleepiness in methamphetamine-dependent individuals". Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1679374131&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Pełny tekst źródłaYingling, Julie Smith. "The relationship between social bond and frequency of methamphetamine use". Click here for download, 2008. http://proquest.umi.com/pqdweb?did=1490085051&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.
Pełny tekst źródłaForrest-Lawrence, Pota. "Media, Policy and the Law: The Case of Crystal Methamphetamine". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15759.
Pełny tekst źródłaNorthrop, Nicole Alia Fazo. "The role of neuroinflammation in stress & methamphetamine-induced damage". Thesis, Boston University, 2012. https://hdl.handle.net/2144/12543.
Pełny tekst źródłaMethamphetamine (Meth) is a widely abused psychostimulant that causes damage to monoamine nerve terminals, marked by long-term depletions of dopamine (DA) and serotonin (5-HT), but the exact mechanisms by which this damage occurs remain unclear. Drug abuse and stress are highly co-morbid in society and therefore, stress should be considered a co-factor in mediating the deleterious effects of Meth. In fact, recent studies illustrate that stress enhances Meth-induced toxicity to monoamine nerve terminals. As both chronic stress and Meth produce a pro-inflammatory state, the current studies examined the role of neuroinflammation in mediating the effects of chronic stress and/or Meth in rats. Exposure to 10 days of chronic unpredictable stress (CUS) increased proinflammatory transcripts and protein expression of the inflammatory mediator, cyclooxygenase (COX)-2. COX activity, in turn, mediated the stress and Meth-induced increases in the proinflammatory enzyme, matrix metalloproteinase-9 (MMP-9). COX and MMP-9, however, were not responsible for the depletions of 5-HT in the hippocampus observed after the serial exposure to CUS and Meth. In contrast, COX activity mediated the enhancement of Meth-induced striatal monoaminergic damage produced by CUS. In addition to damaging monoaminergic terminals, COX activity could mediate blood-brain barrier (BBB) disruption. Thus the effects of stress and Meth on the BBB were examined. Twenty-four hours after the administration of Meth, only rats pre-exposed to CUS showed evidence of BBB disruption reflected by decreases in occludin and claudin-5 and increases in truncation of β-dystroglycan, FITC-dextran extravasation, and brain edema. Except for FITC-dextran extravasation, these effects were blocked by the inhibition of COX. All changes other than β-dystroglycan and edema persisted 7 days later, were paralleled by increases in the inflammatory biomarker, glial fibrillary acidic protein, and were blocked by COX inhibition during and after Meth treatment. These results indicate that stress and Meth synergize to produce a persistent inflammatory state that damages striatal monoaminergic nerve terminals and creates a long-lasting structural and functional BBB disruption. Furthermore, these results suggest that stress can render non-toxic insults toxic through neuroinflammatory mechanisms and implicate the use of anti-inflammatory drugs in combating the neurotoxic effects of chronic stress and drug abuse.
Bardon, James. "A Phenomenological Study of Methamphetamine and Heroin Users’ Arrest Experiences". Diss., NSUWorks, 2018. https://nsuworks.nova.edu/cahss_jhs_etd/11.
Pełny tekst źródłaWahl, Troy Andrew. "Developing Thyronamine Analog Pharmaceuticals Targeting TAAR1 to Treat Methamphetamine Addiction". PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1109.
Pełny tekst źródłaApollonio, Luigino Giuseppe, i n/a. "INNOVATIONS IN SYSTEMATIC TOXICOLOGICAL ANALYSIS: AMPHETAMINETYPE SUBSTANCES AND DESIGNER ANALOGUES". University of Canberra. Applied Science, 2007. http://erl.canberra.edu.au./public/adt-AUC20081030.110007.
Pełny tekst źródłaPrinsloo, Tarryn Kay. "In vitro effects of rooibos herbal tea (Aspalathus linearis) against methamphetamine on the mouse blood brain barrier". University of the Western Cape, 2014. http://hdl.handle.net/11394/4356.
Pełny tekst źródłaMethamphetamine (MA), also known as ‘Tik’, has detrimental short- and long-term psychological and morphological effects on the central nervous system (CNS). The lipophilic nature of MA allows it to cross the blood-brain barrier (BBB) which normally plays a protective role in limiting solute exchange (including narcotics) into the neuronal tissue. Numerous studies have indicated that MA not only crosses the BBB but is implicated in distorting its crucial role in that it increases the permeability of the endothelial cells and thereby compromises its core homeostatic function. The speculated mechanism by which MA elicits its effects involves elevated ROS production which may be reversed by antioxidant treatment. Rooibos herbal tea (Aspalathus linearis) which is well documented for its antioxidative properties and ROS scavenging abilities may therefore be the ideal candidate to reverse the harmful ROS-induced effects of MA. The aim of the study was to investigate the in vitro ameliorating potential of fermented rooibos (Rf) against the MA-induced effects on mouse brain endothelial (bEnd5) cells by utilizing various assays (trypan blue exclusion and XTT viability assays) and physiological parameters (cell numbers, viability, monolayer permeability and cell cycle phases) over a period of 96 hrs. Statistical analysis was performed using the Wilcoxon rank sum test with P<0.05 denoted as significant. Once-off exposure to physiological MA concentrations and Rf resulted in % viability similar to controls by 96 hrs with suppression observed only when the cells were exposed to daily MA (0.1-1000 μM) (P≤0.0063). Exposure to supraphysiological concentrations (≥100 μM) of MA greatly suppressed viability (P≤0.0463). Both daily and once-off treatment to the combinations initially resulted in increased viability however by 96 hrs was similar to- or exceeding the controls (P≤0.0180). MA exposure also resulted in decreased live cell numbers (P≤0.0339) with no effect when exposed to Rf by 96 hrs. The combinations resulted in cell numbers comparable to controls. Dose-dependent increases in electrical resistance were observed in response to singular MA and Rf treatment with lower MA concentrations displaying significant decreases (P≤0.0064). Similar trends were observed with combinations however greater resistance was observed. Increased G1-phase populations (P≤0.0495) in response to singular MA and Rf exposure was noted followed by decreased S-phase fractions (P≤0.0356). While MA decreased G2-M phase cells (P≤0.0498) it was unaffected by Rf. In contrast, the combination of MA and Rf decreased events in the G1-phase (P≤0.0483), with an increased S-phase population (P≤0.0415). In conclusion, the single compounds displayed mirroring effects, decreasing the cells’ permeability and causing G1-phase arrest. The modulatory effects of Rf in combination with MA was illustrated with the restoration of viability and live cell numbers comparable to that of controls, and a more restrictive monolayer as well as reversal of the G1-phase arrest. Findings suggest that Rf may reverse the adverse effects of MA on the BBB.
Pike, Erika. "REINFORCING, SUBJECTIVE, AND COGNITIVE EFFECTS OF METHAMPHETAMINE DURING D-AMPHETAMINE MAINTENANCE". UKnowledge, 2013. http://uknowledge.uky.edu/psychology_etds/15.
Pełny tekst źródłaJones, Lashonda P. "Case menagers' perceptions of the association between methamphetamine and child neglect". DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2008. http://digitalcommons.auctr.edu/dissertations/20.
Pełny tekst źródłaJauregui, Ana. "A study of methamphetamine and other illicit drug usage among youth". Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1527713.
Pełny tekst źródłaThe purpose of this study was to examine the demographic differences in methamphetamine usage among youth and how methamphetamine users engaged in the use of other illegal drugs including, marijuana, cocaine, heroin, ecstasy and also engage in risk taking behaviors. The study utilized secondary data from the National Institute of Health, Youth Behavioral Risk Survey (YRBS) of20011. Sample size consisted of 294 both male and female youth who are methamphetamine users. The findings revealed that drug use amongst youth continues to be on the rise. Findings noted that male meth users had the highest rates of cocaine, ecstasy and heroin use compared to female meth users. The highest rate among female meth users was seen in cocaine use. Findings also revealed that cocaine use was the highest among Hispanic/Latino meth users and ecstasy use was the highest among Non-Hispanic/Latino meth users. In addition findings revealed that a significant association was found in youth's drug use and their involvement in risk taking behaviors. Prior research and findings from this study help society have a more proactive approach when helping youth who suffer from the disease of addiction.
Lal, Ritu Anilkumar 1968. "Plasma protein binding and blood to plasma partitioning studies of methamphetamine". Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277954.
Pełny tekst źródłaFreeman, Carla Patricia. "White matter correlates of neuropsychological function in young adult methamphetamine users". Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22762.
Pełny tekst źródłaBurger, Antoinette. "Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS". Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/21000.
Pełny tekst źródłaGarvis, Pamela J. "Assessing methamphetamine withdrawal symptoms in the residential substance abuse treatment patient". Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1605148101&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Pełny tekst źródłaVincent, Kathryn B. "The ecstasy and methamphetamine drug epidemics implications for prevention and control /". College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/3269.
Pełny tekst źródłaThesis research directed by: Dept. of Criminology and Criminal Justice. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Chen, Mei-yin, i 陳美吟. "Development on Production of Antibodies against Methamphetamine and an Immunochromatographic Strip for Methamphetamine". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/61964801770606585027.
Pełny tekst źródła嘉南藥理科技大學
生物科技系暨研究所
96
Abstract Methamphetamine ( Meth ) is a drug that was initially synthesized to treat central nervous system ( CNS ) disorders such as schizophrenia. This psychostimulant has now become a major drug of abuse worldwide. In high doses, methamphetamine causes hyperactivity, agitation, hyperthermia, hypertension, cardiotoxicity and psychotic disorder such as paranoia. The objective of this study was to produce polyclonal antibody against methamphetamine. The antibody will be used for the application in the development of a nano-particle colloidal gold immunochromatographic strip. In this study, firstly, the drug-proteins bioconjugates had been successfully produced. Meth-BSA bioconjugate was as the immunogen and Meth-sericin bioconjugate was as the antigen. Secondly, production and purification of polyclonal antibody against methamphetamine were made. The pAb concentration was 5.68 mg/mL. Finally, a self-assembled nano-gold immunochromatographic strip was established. The sample required was 80 μL. The concentration range for detection of Meth using this self-assembled immunochromatographic strip was 10 ~50 mg/mL and determination time was 15~30 min. The storage time could be up to 28 days at 4 ℃. The Meth immunochromatographic strip could be applied to test coffee, Coca-Cola, green tea, urine and mice serum. The advantages of the self-assembled immunochromatographic strip are high specificity, high sensitivity, no pretreatment, low sample requirement, easy operation, rapid determination, low price, no cross-reaction, long-term preservation and no machine needed etc.
"Methamphetamine and Novel "Legal High" Methamphetamine Mimetics: Abuse liability, Toxicity, and Potential Pharmacobehavioral Treatments". Doctoral diss., 2014. http://hdl.handle.net/2286/R.I.27393.
Pełny tekst źródłaDissertation/Thesis
Doctoral Dissertation Psychology 2014
Papageorgiou, Marco. "The Immunomodulatory Effects of Methamphetamine". Thesis, 2020. https://vuir.vu.edu.au/41838/.
Pełny tekst źródła"Methamphetamine-induced neurotoxicity in cultured astrocytes". 1999. http://library.cuhk.edu.hk/record=b5889985.
Pełny tekst źródłaThesis (M.Phil.)--Chinese University of Hong Kong, 1999.
Includes bibliographical references (leaves 84-112).
Abstracts in English and Chinese.
Acknowledgment --- p.iii
Abstract --- p.iv
List of Abbreviations --- p.viii
Chapter CHAPTER ONE: --- INTRODUCTION
Chapter 1.1 --- Methamphetamine (METH) --- p.1
Chapter 1.1.1 --- Historical Background and Epidemiology --- p.1
Chapter 1.1.2 --- Physical Effects of METH --- p.4
Chapter 1.1.3 --- Neurochemical Alternation of METH --- p.6
Chapter 1.2 --- Mechanisms of METH Toxicity
Chapter 1.2.1 --- Oxidative Stress --- p.8
Chapter 1.2.1.1 --- Superoxide (O2-) and Superoxide Dismutase (SOD) --- p.10
Chapter 1.2.1.2 --- "Hydrogen Peroxide (H202), Catalase and Glutathione (GSH)" --- p.11
Chapter 1.2.1.3 --- Hydroxyl Radical (OH.) --- p.12
Chapter 1.2.1.4 --- Nitric Oxide (NO) --- p.13
Chapter 1.2.2 --- Apoptosis --- p.16
Chapter 1.2.3 --- Excitotoxicity --- p.17
Chapter 1.2.4 --- Mitochondrial Dysfunction --- p.18
Chapter 1.2.5 --- Hyperthermia --- p.21
Chapter 1.2.5.1 --- Cyclooxygenase-2 (COX-2) --- p.23
Chapter 1.2.5.2 --- Heme-oxygenase-1 (HO-1) --- p.25
Chapter 1.2.5.3 --- The Effects of Nitric Oxide (NO) on COX-2 and HO-1 Expressions --- p.27
Chapter 1.3 --- Astrocytes
Chapter 1.3.1 --- Characteristics of Astrocytes --- p.29
Chapter 1.3.2 --- Astrocyte Functions --- p.30
Chapter 1.3.3 --- The Role of Astrocytes in METH-induced Neurotoxicity --- p.34
Chapter 1.4 --- Aim of Project --- p.37
Chapter CHAPTER TWO: --- MATERIALS AND METHODS
Chapter 2.1 --- Cell Cultures
Chapter 2.1.1 --- Astrocyte Cultures --- p.42
Chapter 2.1.2 --- CATH.a Cell line and Astrocytes Co-cultures --- p.43
Chapter 2.2 --- Treatment
Chapter 2.2.1 --- METH Treatment --- p.44
Chapter 2.2.2 --- Inhibition of Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (iNOS) --- p.44
Chapter 2.3 --- Lactate Dehydrogenase (LDH) Assay --- p.45
Chapter 2.4 --- Assay for Reactive Oxygen Species (ROS) Formation --- p.47
Chapter 2.5 --- Assay for Adenosine Triphosphate (ATP) Content --- p.48
Chapter 2.6 --- Determination of Mitochondrial Membrane Potential (Δ Ψm) --- p.50
Chapter 2.7 --- Determination of Nitrite Levels in Cultured Astrocytes --- p.51
Chapter 2.8 --- Western Blot Analysis --- p.52
Chapter 2.8.1 --- COX-2 --- p.53
Chapter 2.8.2 --- HO-1 --- p.53
Chapter 2.9 --- Viability Assay of CATH.a-Astrocyte Cocultures --- p.54
Chapter 2.10 --- Statistics --- p.55
Chapter CHAPTER THREE: --- RESULTS
Chapter 3.1 --- The Effects of METH Treatment on Cultured Astrocytes
Chapter 3.1.1 --- Lactate Dehydrogenase (LDH) Activities --- p.56
Chapter 3.1.2 --- Morphological Changes --- p.56
Chapter 3.1.3 --- The Production of Reactive Oxygen Species
Chapter 3.1.3.1 --- Rate of change (0-120 min) --- p.57
Chapter 3.1.3.2 --- Time course (0 - 48 h) --- p.57
Chapter 3.1.4 --- Change in ATP Content --- p.58
Chapter 3.1.5 --- Change in Mitochondrial Membrane Potential (Δ Ψm) --- p.59
Chapter 3.1.6 --- Nitrite levels after METH treatment
Chapter a) --- Striatal astrocytes --- p.59
Chapter b) --- Mesencephalic astrocytes --- p.60
Chapter c) --- Cortical astrocytes --- p.60
Chapter 3.1.7 --- The Effects of Aminoguanidine (AG) on Nitrite Levels
Chapter a) --- Striatal astrocytes --- p.61
Chapter b) --- Mesencephalic astrocytes --- p.62
Chapter c) --- Cortical astrocytes --- p.62
Chapter 3.1.8 --- The Effects of Indomethacin (INDO) on Nitrite Levels
Chapter a) --- Striatal astrocytes --- p.63
Chapter b) --- Mesencephalic astrocytes --- p.64
Chapter c) --- Cortical astrocytes --- p.64
Chapter 3.1.9 --- Change in Cyclooxygenase-2 (COX-2) Protein Levels
Chapter a) --- Striatal astrocytes --- p.65
Chapter b) --- Mesencephalic astrocytes --- p.65
Chapter c) --- Cortical astrocytes --- p.66
Chapter 3.1.10 --- Change in Heme-oxygenase-1 (HO-1) Protein Levels
Chapter a) --- Striatal astrocytes --- p.66
Chapter b) --- Mesencephalic astrocytes --- p.66
Chapter c) --- Cortical astrocytes --- p.67
Chapter 3.2 --- Cell Viability on CATH.a-Astrocyte Cocultures After METH Treatment --- p.67
Chapter CHAPTER FOUR: --- DISCUSSION AND CONCLUSION --- p.69
REFERENCES --- p.84
Chiang, Chih-yuan, i 江致遠. "Anatomical Substrates of the Methamphetamine Memory". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/39030262073261658667.
Pełny tekst źródła國立成功大學
行為醫學研究所
96
Immunohistochemical Fos staining has proved to be a method to identify the loci of activated neurons specific to a stimulus. Although the methamphetamine (MA)-conditioned place preference (CPP) is a long-term memory, how and where the MA-CPP memory was stored and retrieved remained unknown. In this study, a conditioning procedure comprising of vehicle (saline) injection and previously-conditioned environment presentation, not performance test, was used as a way to reactivate the MA-CPP memory. Activated neurons in the limbic system following this MA-CPP memory reactivation were examined by employing immunohistochemical Fos staining. We demonstrated that the current conditioning procedure produced reliable MA-CPP memory and performance. Moreover, enhanced Fos expressions were obviously found in medial prefrontal cortex and the core of nucleus accumbens while the MA-CPP memory was reactivated. Different from many findings, familiarity with environmental cues/context in a novel surrounding (the CPP chamber) was found to significantly enhance neuronal activity in dorsal part of the striatum and the dentate gyrus. Nucleus accumbens shell, basolateral or lateral amygdala, in this regard, did not seem to be involved in the MA-CPP memory storage or retrieval. These results, taken together, suggest that medial prefrontal cortex and nucleus accumbens core are anatomical substrates responsible for storage and reactivation of the MA-conditioned cues/context-associated memory in the limbic system.
"Methamphetamine: Examining Arizona's Drug Endangered Children". Master's thesis, 2011. http://hdl.handle.net/2286/R.I.8951.
Pełny tekst źródłaDissertation/Thesis
M.S. Family and Human Development 2011