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Ünlü, Begüm, i Ümit Türsen. "Autoimmune skin diseases and the metabolic syndrome". Clinics in Dermatology 36, nr 1 (styczeń 2018): 67–71. http://dx.doi.org/10.1016/j.clindermatol.2017.09.012.
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Muinovna, Khamidova Farida. "MORPHOGENETIC CHARACTERISTICS OF KERATODERMA IN METABOLIC DISORDERS". American Journal Of Biomedical Science & Pharmaceutical Innovation 4, nr 6 (1.06.2024): 54–69. http://dx.doi.org/10.37547/ajbspi/volume04issue06-09.
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Studying the morphological and genetic different types of keratoses is key for correct diagnosis and choice of treatment. The association between metabolic disorders and skin diseases highlights the need for an integrated approach to the management of patients with chronic diseases, including diabetes mellitus. Further research is needed to better understand the pathogenesis and develop effective treatments.
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Urrets-Zavalía, Julio A., Evangelina Espósito, Iliana Garay, Rodolfo Monti, Alejandro Ruiz-Lascano, Leandro Correa, Horacio M. Serra i Andrzej Grzybowski. "The eye and the skin in endocrine metabolic diseases". Clinics in Dermatology 34, nr 2 (marzec 2016): 151–65. http://dx.doi.org/10.1016/j.clindermatol.2015.12.001.
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Napolitano, Maddalena, Matteo Megna i Giuseppe Monfrecola. "Insulin Resistance and Skin Diseases". Scientific World Journal 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/479354.
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In medical practice, almost every clinician may encounter patients with skin disease. However, it is not always easy for physicians of all specialties to face the daily task of determining the nature and clinical implication of dermatologic manifestations. Are they confined to the skin, representing a pure dermatologic event? Or are they also markers of internal conditions relating to the patient’s overall health? In this review, we will discuss the principal cutaneous conditions which have been linked to metabolic alterations. Particularly, since insulin has an important role in homeostasis and physiology of the skin, we will focus on the relationships between insulin resistance (IR) and skin diseases, analyzing strongly IR-associated conditions such as acanthosis nigricans, acne, and psoriasis, without neglecting emerging and potential scenarios as the ones represented by hidradenitis suppurativa, androgenetic alopecia, and hirsutism.
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Sirufo, Maria Maddalena, Francesca De Pietro, Enrica Maria Bassino, Lia Ginaldi i Massimo De Martinis. "Osteoporosis in Skin Diseases". International Journal of Molecular Sciences 21, nr 13 (3.07.2020): 4749. http://dx.doi.org/10.3390/ijms21134749.
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Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice.
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Pozdnyakova, O. N., O. B. Nemchaninova, S. G. Lykova i T. B. Reshetnikova. "Clinical features of «metabolism» diseases of the skin in patients with chronic diffuse liver diseases". Terapevticheskii arkhiv 89, nr 1 (15.01.2017): 49–52. http://dx.doi.org/10.17116/terarkh201789149-52.
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Aim. To determine the clinical features of skin diseases developing in the presence of metabolic disturbances in patients with chronic diffuse liver diseases. Subjects and methods. A total of 368 patients with different clinical forms of hepatopathy were comprehensively examined. Results. 817 cases of seborrhea, skin itch, xerodermia, xanthomatosis, and dyschromia were detected in 318 (86.4%) patients. Conclusion. The prevalence and intensity of cutaneous manifestations depended on the nature of the pathological liver process and indirectly testified to its severity and activity. The symptoms of skin diseases were most pronounced in patients with autoimmune liver lesions, chronic toxic hepatitis, and cirrhosis.
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Furue, Masutaka, Gaku Tsuji, Takahito Chiba i Takafumi Kadono. "Cardiovascular and Metabolic Diseases Comorbid with Psoriasis: Beyond the Skin". Internal Medicine 56, nr 13 (2017): 1613–19. http://dx.doi.org/10.2169/internalmedicine.56.8209.
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Bakalets, N. F., i L. A. Poroshina. "Metabolic Syndrome as a Risk Factor for Skin Pathology". Health and Ecology Issues, nr 4 (28.12.2018): 9–15. http://dx.doi.org/10.51523/2708-6011.2018-15-4-2.
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Wierzcholski, Krzysztof. "The Metabolic Process After Lubrication of Human Joint and Skin Surfaces". Clinical Research Notes 3, nr 3 (30.04.2022): 01–11. http://dx.doi.org/10.31579/2690-8816/058.
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Purpose The topic of the presented paper concerns the human body and joint cartilage run-walk treatment implemented by the Electro-Magnetic (EM) and Acoustic Emission (AE) field. The thesis is proved here i.e. running in presence of a EM and AE field, increases dynamic viscosity of bio-lubricant liquids, thus increases energy burn, metabolism and finally it leads to the decrements of the body weight and hence it accelerates the slimming process. Material and Methods The research methods used in this paper include the following: EM field produced by a new Polish Apparatus MF-24, MT-3, Germany Magcell Arthro magneto electronic devices for the human body and joint cartilage treatment, Bone Dias Apparatus applied in AE therapy produced in Germany, ( Univ. Applied Science Giessen), Segmental Body Composition Analyzer Tanita MC 780MA, pedometer Garmin Ltd.2015.The author gained experience in Germany research institutes, and practical results were obtained after measurements and information from students and patients. Results The EM-therapy and AE results presented in this paper concern betterments during typical human cartilage diseases and causes of the effects of the slimming process gained before and after run-walk training. The run-walk training results presented in this paper concern the effects of the slimming process gained without and after electro-magnetic field therapy. Conclusions The main conclusions obtained in this paper are as follows: The run-walk training implemented by the electro-magnetic induction field and AE leads to the increments of the dynamic viscosity of synovial fluid and human sweat, changes the internal energy contained in the human body, muscle and cartilage, hence it accelerates the slimming process connected with the body weight decrements as well the betterments effects during the therapy.
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Curtis, Ashley R. "Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Diseases". American Journal of Dermatopathology 33, nr 2 (kwiecień 2011): 203. http://dx.doi.org/10.1097/dad.0b013e31820e34f0.
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Burgdorf, Walter. "Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Diseases". Journal of Cutaneous Pathology 38, nr 9 (26.04.2011): 759. http://dx.doi.org/10.1111/j.1600-0560.2011.01707.x.
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Ho, Qing Wei Calvin, Xiaofeng Zheng i Yusuf Ali. "Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation". International Journal of Molecular Sciences 23, nr 17 (26.08.2022): 9697. http://dx.doi.org/10.3390/ijms23179697.
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Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on discerning specific ceramide species and their effects on atopic dermatitis, obesity, type 2 diabetes, and cardiovascular diseases. This delineation has allowed the identification of disease biomarkers, with long acyl chain ceramides such as C16- and C18-ceramides linked to metabolic dysfunction and cardiac function decline, while ultra-long acyl chain ceramides (>25 carbon acyl chain) were reported to be essential for maintaining a functional skin barrier. Given the intricate link between free fatty acids with ceramides, especially the de novo synthetic pathway, intracellular lipid droplet formation is increasingly viewed as an important mechanism for preventing accumulation of toxic ceramide species. Here, we review recent reports of various ceramide species involved in skin abnormalities and metabolic diseases, and we propose that promotion of lipid droplet biogenesis can be seen as a potential protective mechanism against deleterious ceramides.
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Vebman, Jonathan Ilai, Alexa Choy i Christopher Yao. "Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis". SKIN The Journal of Cutaneous Medicine 4, nr 2 (8.03.2020): 112. http://dx.doi.org/10.25251/skin.4.2.3.
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Introduction:-Psoriasis is a common disease that is linked with several other diseases. Our goals were to analyze and present literature on prevalence of various psoriatic comorbidities, and provide an estimate of what percent of psoriasis patients might have or develop Myocardial/cardiovascular/heart disease, stroke, diabetes, obesity, hypertension, or metabolic syndrome.Method:-To collect the results, we searched PubMed to identify papers that studied the frequency of the most common comorbidities of psoriasis. We used about 20. The search terms used were the particular comorbidity (or synonyms) and psoriasis. Papers were selected where the prevalence data were listed by percentages of the studied population. Prevalence data from each paper were collected and charted, and then compared. We did not use data that concerned Psoriatic Arthritis. We also recorded outliers, where frequencies did not fit with the other data found.Results:-Results for prevalence of myocardial/cardiovascular/heart disease were mixed, varying by age and severity of disease. There are few papers on prevalence of stroke, but our review suggests risk of stroke increases with severity of psoriasis. The prevalence of diabetes was largely between 10% and 20%. Obesity’s prevalence was mostly between 15% and 30%, while hypertension hovered around 30%, and metabolic syndrome prevalence was mostly between 27% and 50%.Conclusions:-There are many comorbidities of psoriasis. The complex interaction between cutaneous inflammation and heart disease, stroke, diabetes, hypertension and metabolic syndrome raises many questions about cause and effect or simple association.
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Purim, Kátia Sheylla Malta, Ana Cláudia Kapp Titski i Neiva Leite. "Dermatological aspects influencing the practice of physical activities by obese individuals". Fisioterapia em Movimento 28, nr 4 (grudzień 2015): 837–50. http://dx.doi.org/10.1590/0103-5150.028.004.ar02.
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Abstract Objective : The aim of this study was to perform a systematic review of the major skin diseases affecting obese individuals and their influence on physical activity. Methods : Relevant articles were identified by systematically searching PubMed from 2000 to 2014, using the descriptors "skin diseases" and "obesity", "skin disease" and "obesity", "skin diseases" and "physical activity", "skin disease" and "physical activity". The PEDro Scale (in Brazilian Portuguese) was used to rate the methodological quality of the studies. Results : A total of 320 articles were examined in the first phase. In the end, 11 articles met the proposed criteria and were included for analysis in the systematic review. We investigated cutaneous manifestations of diseases and classified them according to their effects under 5 categories: metabolic (n = 10), aesthetic (n = 7), inflammatory (n = 6), mechanical (n = 5) and infectious (n = 3). The most frequent dermatoses among obese were acanthosis nigricans, acrochordon (skin tags), stretch marks, plantar keratodermia, intertrigo, bacterial and fungal infections. Acanthosis nigricans was found to be the most important metabolic implication of obesity. Conclusion : Although neglected, skin lesions are common in obesity and have implications for physical activity because they cause pain, discomfort, friction, infection, inflammation, embarrassment, limitation or difficulty of movement. Strategies to promote skin health may result in a better integration of physical activity into routine therapy and improve the quality of life of obese individuals.
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Leite, Beatriz, Alexia Brito, Catharina Kensy, Ana Luiza Bosi, Fernanda Frota, Julia Lavoratto i Eduardo Chagas. "The prevalence of metabolic skin diseases in the population with Diabetes Mellitus". Concilium 24, nr 9 (14.05.2024): 526–36. http://dx.doi.org/10.53660/clm-3414-24i30.
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Objective: To carry out an integrative review of the literature on the prevalence of dermatological diseases in individuals with Diabetes Mellitus (DM) types 1 and 2. Methods: this integrative literature review Result: Dermatophytosis was the skin lesion most frequently associated with DM, types 1 and 2, with a 48% prevalence in the studies analyzed. Conclusion: there is a clear need for early diagnosis of injuries and subsequent adequate treatment, in addition to proper adherence to glycemic control, so that systemic complications do not occur.
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Gorlanov, Igor A., Larisa M. Leina, Yulia L. Skorodok i Irina R. Milyavskaya. "Cutaneous manifestations of endocrine diseases in children". Pediatrician (St. Petersburg) 12, nr 2 (11.08.2021): 53–64. http://dx.doi.org/10.17816/ped12253-64.
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Endocrine diseases such as obesity, diabetes mellitus, Cushings syndrome, hypothyroidism and hyperthyroidism, acromegaly and hyperandrogenism in children and adolescents are often manifested by changes in the skin. Moreover, skin symptoms can be a marker of systemic, in this case, endocrine and metabolic diseases. Obesity and diabetes are chronic diseases that affect people all over the world, and their incidence is increasing in both children and adults. Clinically, they affect a number of organs, including the skin. The cutaneous manifestations caused or aggravated by obesity and diabetes are varied and usually bear some relation to the time that has elapsed since the onset of the disease. They include acrochordons, acanthosis nigricans, striae, xerosis, keratosis pilaris, plantar hyperkeratosis, fungal and bacterial skin infections, granuloma annulare, necrobiosis lipoidica. In obese patients, psoriasis and atopic dermatitis are more common than in the control group. With the pathology of the thyroid gland, diseases such as alopecia, pretibial myxedema, urticaria, and some others develop. Hyperandrogenism (polycystic ovary syndrome) is accompanied by skin lesions such as acne vulgaris, hirsutism, androgenic alopecia, acanthosis nigricans. This literature review focuses on the main skin syndromes accompanying endocrine pathology in children and adolescents. Information about such clinical associations can make it easier for pediatricians and endocrinologists to diagnose and treat endocrine diseases in a timely manner and, thereby, prevent long-term adverse consequences.
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HRYTSEVICH, N. R., i V. V. VERESCHAKA. "Functional condition of the skin in women with metabolic syndrome". Experimental and Clinical Physiology and Biochemistry 97, nr 3 (30.11.2023): 14–18. http://dx.doi.org/10.25040/ecpb2023.03.014.
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It is known that in people with metabolic diseases, reparation processes are disturbed during surgical interventions. However, the functional state of the skin during the development of the metabolic syndrome has been little studied. The aim of the work was to investigate the functional state of the skin in women with metabolic syndrome. Materials and methods. The study included 60 women aged 39 to 55 who sought surgical care for cosmetic skin defects. The control group consisted of 30 practically healthy women. Signs of metabolic syndrome were registered in 30 women who were included in the main group. The rate of reproduction of basal keratinocytes was determined according to the method of P. V. Kozhevnikova. The neutralizing ability of the skin was determined by the colorimetric method according to the time of disappearance of the bright crimson color (in minutes). The elastometric indicators of the skin were studied by the vacuum aspiration method using an applied cuvette with a diameter of 20 mm at a negative pressure of 20 kPa. The results. It was found that in women with metabolic syndrome, the duration of exfoliation of the stratum corneum increased by 48.1% (p < 0.01) compared to controls. This indicates a decrease in the rate of division of basal epidermocytes in the case of the development of metabolic syndrome. In the main group, the neutralization of the irritating agent was slower by 24.1% (p < 0.01), which indicates a decrease in the reactogenic properties of the skin in people with signs of metabolic syndrome. In patients with metabolic syndrome, the elastometric index of the skin increased by 46.0% (p < 0.001), which indicates changes in the tinctorial properties of the skin associated with the metabolic destruction of collagen. Conclusion. Significant changes in the functional state of the skin were registered in women with metabolic syndrome compared to healthy women: the rate of division of basal keratinocytes decreased, the elasticity of the skin deteriorated, and the index of its reactogenicity decreased. The identified changes, to a certain extent, explain the reasons for the violation of reparative processes in the skin after surgical interventions. Key words: metabolic syndrome, exfoliation of the stratum corneum of the skin, rate of division of basal keratinocytes, skin elasticity.
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Mettang, Thomas, i Markus Streit. "Hautveränderungen als Schlüssel zur Diagnose systemischer Erkrankungen". DMW - Deutsche Medizinische Wochenschrift 143, nr 23 (listopad 2018): 1690–99. http://dx.doi.org/10.1055/a-0569-3822.
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AbstractMany systemic diseases go along with dermal involvement. Only a few of systemic diseases show characteristic skin derangements directly leading to the diagnosis of the underlying disease. Ten of these entities are described within this article. Some of these are autoimmune diseases, such as systemic lupus erythematodes, dermatomyositis or the anti-synthetase-syndrome. Others are genetic diseases with benign or malignant neoplasias (Peutz-Jeghers-syndrome, neurofibromatosis, tuberous sclerosis, Birt-Hogg-Dubé-syndrome, Cowden-syndrome). Other genetically based diseases with typical skin manifestations are characterised by vascular malformations (Pseudoxanthoma elasticum and Osler-Weber-Rendu syndrome) or metabolic and structural organ defects (Morbus Fabry, cystic fibrosis). Being familiar with the typical skin-appearance of these diseases will allow physicians and general practitioners to make a timely diagnosis.
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Conde, Tiago, Diana Lopes, Wojciech Łuczaj, Bruno Neves, Bruno Pinto, Tatiana Maurício, Pedro Domingues, Elżbieta Skrzydlewska i M. Rosário Domingues. "Algal Lipids as Modulators of Skin Disease: A Critical Review". Metabolites 12, nr 2 (20.01.2022): 96. http://dx.doi.org/10.3390/metabo12020096.
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The prevalence of inflammatory skin diseases continues to increase with a high incidence in children and adults. These diseases are triggered by environmental factors, such as UV radiation, certain chemical compounds, infectious agents, and in some cases, people with a genetic predisposition. The pathophysiology of inflammatory skin diseases such as psoriasis or atopic dermatitis, but also of skin cancers, is the result of the activation of inflammation-related metabolic pathways and the overproduction of pro-inflammatory cytokines observed in in vitro and in vivo studies. Inflammatory skin diseases are also associated with oxidative stress, overproduction of ROS, and impaired antioxidant defense, which affects the metabolism of immune cells and skin cells (keratinocytes and fibroblasts) in systemic and skin disorders. Lipids from algae have been scarcely applied to modulate skin diseases, but they are well known antioxidant and anti-inflammatory agents. They have shown scavenging activities and can modulate redox homeostasis enzymes. They can also downmodulate key inflammatory signaling pathways and transcription factors such as NF-κB, decreasing the expression of pro-inflammatory mediators. Thus, the exploitation of algae lipids as therapeutical agents for the treatment of inflammatory skin diseases is highly attractive, being critically reviewed in the present work.
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Hagyousif, Yousra A., Basma M. Sharaf, Ruba A. Zenati, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah i in. "Skin Cancer Metabolic Profile Assessed by Different Analytical Platforms". International Journal of Molecular Sciences 24, nr 2 (13.01.2023): 1604. http://dx.doi.org/10.3390/ijms24021604.
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Skin cancer, including malignant melanoma (MM) and keratinocyte carcinoma (KC), historically named non-melanoma skin cancers (NMSC), represents the most common type of cancer among the white skin population. Despite decades of clinical research, the incidence rate of melanoma is increasing globally. Therefore, a better understanding of disease pathogenesis and resistance mechanisms is considered vital to accomplish early diagnosis and satisfactory control. The “Omics” field has recently gained attention, as it can help in identifying and exploring metabolites and metabolic pathways that assist cancer cells in proliferation, which can be further utilized to improve the diagnosis and treatment of skin cancer. Although skin tissues contain diverse metabolic enzymes, it remains challenging to fully characterize these metabolites. Metabolomics is a powerful omics technique that allows us to measure and compare a vast array of metabolites in a biological sample. This technology enables us to study the dermal metabolic effects and get a clear explanation of the pathogenesis of skin diseases. The purpose of this literature review is to illustrate how metabolomics technology can be used to evaluate the metabolic profile of human skin cancer, using a variety of analytical platforms including gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR). Data collection has not been based on any analytical method.
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Abramovich, Caroline M., Richard A. Prayson, James T. McMahon i Bruce H. Cohen. "Ultrastructural examination of the axillary skin biopsy in the diagnosis of metabolic diseases". Human Pathology 32, nr 6 (czerwiec 2001): 649–55. http://dx.doi.org/10.1053/hupa.2001.24995.
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Abdel Hay, RaniaM, Dina Kadry, OlaM Abu Zeid, OmarS El Safoury, MarwaM Fawzy, ImanM Amin i LailaA Rashed. "Skin tags, leptin, metabolic syndrome and change of the life style". Indian Journal of Dermatology, Venereology, and Leprology 77, nr 5 (2011): 577. http://dx.doi.org/10.4103/0378-6323.84061.
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Teixeira, Vera, Inês Coutinho, Rita Gameiro, Ricardo Vieira i Margarida Gonçalo. "Dermatoses Específicas da Gravidez". Acta Médica Portuguesa 26, nr 5 (31.10.2013): 593. http://dx.doi.org/10.20344/amp.2006.
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During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specificdermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the knowledge of the pathogenesis of these skin diseases. Currently the following diseases are considered specific dermatoses of pregnancy:pemphigoid gestations, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy and atopic eruption of pregnancy. Timely diagnosis and specific and safe treatment are essential to prevent complications which, although rare, may be associated with significant maternal-fetal comorbidity.
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Patil, Rashmi, i Urmila Aswar. "Role of Pterostilbene in Metabolic Diseases through SIRT1 pathway- A Review". Turkish Journal of Agriculture - Food Science and Technology 9, sp (7.01.2022): 2581–86. http://dx.doi.org/10.24925/turjaf.v9isp.2581-2586.4938.
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Pterostilbene (PTE) (3-5 dimethoxy-4-hydroxy-trans-stilbenes) is an analogue of resveratrol. It is extracted and isolated from a natural source of the heartwood of Pterocarpus marsupium Roxb., red grape skin, and blueberries (Vaccinium spp.). Substantial evidence suggested that PTE displayed numerous preventive and therapeutic properties in many metabolic disorders such as diabetes and obesity. Metabolic diseases result in Insulin resistance (IR) which advances to impaired sensitivity to insulin-mediated glucose disposal. The prominent role of SIRT (silent information regulator proteins) is now getting emphasized in metabolic disorders. SIRT1 represses Uncoupling protein 2 (UCP2) expressions which are further responsible for improving synthesis of ATP from glucose. This results in improving glucose utilization and insulin secretion, thus preventing IR. SIRT1 also exhibits prominent role in facilitating fatty acid mobilization thereby inhibiting adiposity. Metabolic disorders are therefore the consequences of SIRT1 downregulation. Pterostilbene, being a SIRT1 activator, increases insulin sensitivity reduces adiposity, therefore can prove to be beneficial in diabetes as well as obesity. The review summarizes therapeutic effects portrayed by Pterostilbene via the SIRT1 pathway in metabolic diseases.
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Vaughan Jones, SA, i MM Black. "Skin disorders in pregnancy". Fetal and Maternal Medicine Review 9, nr 3 (sierpień 1997): 147–62. http://dx.doi.org/10.1017/s0965539597000107.
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During pregnancy there are profound metabolic, endocrine and vascular changes which are tolerated for a short period of time. As the skin represents the largest organ of the body, these changes are also reflected in the appearance of the skin both by the improvement or exacerbation of pre-existing skin disease and by the development of new dermatoses. The specific dermatoses of pregnancy are a group of disorders which only occur in the pregnant state.This review will discuss the physiological effects of pregnancy on the appearance and function of normal skin, and other cutaneous diseases affected by pregnancy (including intrahepatic cholestasis). The latter part of the review will discuss important aspects of the specific dermatoses of pregnancy.
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Sileno, Sara, Sara Beji, Marco D’Agostino, Alessandra Carassiti, Guido Melillo i Alessandra Magenta. "microRNAs involved in psoriasis and cardiovascular diseases". Vascular Biology 3, nr 1 (29.06.2021): R49—R68. http://dx.doi.org/10.1530/vb-21-0007.
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Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular disease (CVD), and cerebrovascular diseases (CeVD). Indeed, life expectancy in severe psoriasis is reduced by up to 5 years due to CVD and CeVD. Moreover, patients with severe psoriasis have a higher prevalence of traditional cardiovascular (CV) risk factors, including dyslipidemia, diabetes, smoking, and hypertension. Further, systemic inflammation is associated with oxidative stress increase and induces endothelial damage and atherosclerosis progression. Different miRNA have been already described in psoriasis, both in the skin tissues and in the blood flow, to play a role in the progression of disease. In this review, we will summarize and discuss the most important miRNAs that play a role in psoriasis and are also linked to CVD.
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Matsumoto, Mai, Hiroyuki Suganuma, Sunao Shimizu, Hiroki Hayashi, Kahori Sawada, Itoyo Tokuda, Kazushige Ihara i Shigeyuki Nakaji. "Skin Carotenoid Level as an Alternative Marker of Serum Total Carotenoid Concentration and Vegetable Intake Correlates with Biomarkers of Circulatory Diseases and Metabolic Syndrome". Nutrients 12, nr 6 (19.06.2020): 1825. http://dx.doi.org/10.3390/nu12061825.
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To confirm the usefulness of noninvasive measurements of skin carotenoids to indicate vegetable intake and to elucidate relationships between skin carotenoid levels and biomarkers of circulatory diseases and metabolic syndrome, we conducted a cross-sectional study on a resident-based health checkup (n = 811; 58% women; 49.5 ± 15.1 years). Skin and serum carotenoid levels were measured via reflectance spectroscopy and high-performance liquid chromatography, respectively. Vegetable intake was estimated using a dietary questionnaire. Levels of 9 biomarkers (body mass index [BMI], brachial-ankle pulse wave velocity [baPWV], systolic and diastolic blood pressure [SBP and DBP], homeostasis model assessment as an index of insulin resistance [HOMA-IR], blood insulin, fasting blood glucose [FBG], triglycerides [TGs], and high-density lipoprotein cholesterol [HDL-C]) were determined. Skin carotenoid levels were significantly positively correlated with serum total carotenoids and vegetable intake (r = 0.678 and 0.210, respectively). In women, higher skin carotenoid levels were significantly associated with lower BMI, SBP, DBP, HOMA-IR, blood insulin, and TGs levels and higher HDL-C levels. In men, it was also significantly correlated with BMI and blood insulin levels. In conclusion, dermal carotenoid level may indicate vegetable intake, and the higher level of dermal carotenoids are associated with a lower risk of circulatory diseases and metabolic syndrome.
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Costa, Diana, i Filipe Gonçalves. "Quando suspeitar de Síndrome Metabólica no Exame Físico e qual a relevância para a Saúde Ocupacional?" Revista Portuguesa de Saúde Ocupacional 10 (31.12.2020): 1–20. http://dx.doi.org/10.31252/rpso.12.09.2020.
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Introduction / background / objective In a western world marked by a high prevalence of metabolic changes related to metabolic syndrome (obesity, cardiovascular diseases, type 2 diabetes mellitus, high blood pressure, dyslipidemia), it is essential to know where to look and recognize early signs. In companies, it is common to find workers with various risk factors that characterize metabolic syndrome since the environment and work organization can have an influence (such as inappropriate food choices in cafeteria or vending machines, work organization and stress, or shift work and its impact on circadian rhythm). Its consequences will cause more illnesses, more work accidents and bigger losses for companies. Therefore, in occupational health services, there is another way to invest in the development of health and well-being, in addition to the direct prevention of occupational diseases and accidents at work, by analyzing the worker from a global point of view throughout his life, and acting in synergy with Primary Health Care. The main objective of this work is to elaborate a review of the cutaneous manifestations that can provide clues during the physical exam, having as main focus the metabolic syndrome. Methodology It is a Scoping Review, carried out in the EBSCO databases (CINAHL, MEDLINE, Nursing & Allied Health Collection: Comprehensive, Cochrane Database, MedicLatina), PUBMED and RCAAP, in the period of June 2020. The keywords used were: “Skin manifestations”, “Signs on the skin”, “Insulin resistance”, “Metabolic syndrome”. Results Several signs suggestive of metabolic syndrome or insulin resistance were found, namely acanthosis nigricans, acrochordons/skin tags, xanthelasmas, eruptive xanthomas, diagonal earlobe crease/ Frank’s sign, some inflammatory skin manifestations (acne, hidradenitis suppurativa) and autoimmune (psoriasis, vitiligo). Conclusions It is essential to encourage lifestyle changes that address Metabolic Syndrome. Empowering or reminding professionals of non-invasive assessment techniques for signals recognition, can contribute to helping the team to detect metabolic manifestations early, simply by looking at the skin of those they care for. This approach can be an asset in occupational health services, which are at the forefront of monitoring adults, and whose disease course can be controlled or even reversed with early diagnosis and intervention. In fact, analyzing the worker in his entire definition of health (adding Preventive Medicine / Nursing to Curative) and working in synergy with Primary Health Care, will end up influencing the productivity of companies (by avoiding sick leave due to illness, or even reducing work accidents).
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Verma, Shyam B. "Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease". International Journal of Dermatology 51, nr 1 (20.12.2011): 111. http://dx.doi.org/10.1111/j.1365-4632.2011.05162.x.
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Pankiv, I. V. "Insulin resistance in patients with psoriasis". INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17, nr 7 (12.01.2022): 570–74. http://dx.doi.org/10.22141/2224-0721.17.7.2021.244973.
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Psoriasis is a chronic systemic inflammatory disease accompanied by an activation of skin dendritic cells with accumulation in the inflammatory foci of interleukin-23 and activated Th-1 lymphocytes (Th-17, Th-22). In recent years, there has been a large number of evidence linking psoriasis with other inflammatory diseases, including obesity, diabetes mellitus, atherosclerosis, hypertension, nonalcoholic fatty liver disease, polycystic ovary syndrome, benign prostatic hyperplasia, etc. All of these conditions are associated with systemic inflammation and insulin resistance induced by it. Psoriasis is the most common chronic dermatosis and affects 1–2 % of the population in developed countries. Psoriasis as a chronic immune-mediated inflammatory skin disease is often associated with metabolic syndrome and its components such as obesity, hypertension, insulin resistance and dyslipidemia. The risk of developing metabolic syndrome in patients with psoriasis is 40 % higher than in the general population. Psoriasis and metabolic syndrome share some pathogenic mechanisms such as chronic low-grade systemic inflammation and an increased level of pro-inflammatory cytokines. Systemic inflammation causes obesity, cardiovascular diseases, diabetes mellitus type 2. These conditions increase the risk of mortality among patients with psoriasis. There is a positive correlation between the severity of psoriasis and metabolic syndrome, which is manifested by a severe rash, reduction of the remission and higher risk of psoriatic arthritis development. The carriers of the risk allele of FTO gene are characterized by a more severe psoriasis, the presence of psoriatic arthritis and increased body mass index. A review of the literature focuses on the relationship between insulin resistance and the pathogenesis of psoriasis.
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Gouma, Perena. "(Invited) Breath and Skin Gas Sensing for Rapid POC Medical Diagnostics". ECS Meeting Abstracts MA2023-02, nr 63 (22.12.2023): 2974. http://dx.doi.org/10.1149/ma2023-02632974mtgabs.
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Antiquity’s first known physician, Hippocrates of Cos (460–370 BC), smelled his patients’ breath to diagnose disease and recommend the appropriate remedy. Some medical terms coined then survive today, such as “fetor hepaticus,” which describes the sweet, ketone- and ammonia- rich scent that indicates the late stages of liver failure. Yet, neither breath nor skin analysis, as a noninvasive means of disease detection, are common practice among physicians to-date nor are they available to the general population. Ceramic sensor nanotechnology and nanomedicine are, however, capable of making breath-based diagnostics. VOCs in breath and skin are products of core metabolic processes, while inorganic molecules are related to other health conditions and can be indicators of a potential disease, recent exposure to a drug or an environmental pollutant. Therefore, an abnormally high or low measured concentration of certain breath or skin gases, so-called biomarkers, could potentially provide clues for diagnosing corresponding diseases. This work focuses on electronic olfaction systems which we have developed and used in breath-based testing of Volatile Organic Compound (VOC) biomarkers with great success. It also addresses the concept of skin-gas “smelling” of disease. These gas sensing nanotechnologies allow for the rapid and reliable output signals which indicate the host’s response to infection or metabolic changes. Using the library of specific prints/unique patterns for each of the targeted diseases, the following types of diseases could be potentially diagnosed: Metabolic diseases: diabetes, cholesterol-induced heart disease; Neurological diseases: Alzheimers, Parkinson’s; Chronic diseases: obesity, sleep apnea; Pulmonary diseases: CF, asthma, COPD; GI tract diseases: IBS, colitis; Cancers: breast, lung, pancreatic, colon, and Infectious diseases: flu, COVID-19; as well as diseases commonly found in ICU patients: Urinary tract infections, pneumonia, infections of the blood stream. Focusing on the most common gaseous biomarkers in breath and skin, that is Nitric Oxide and Carbon Monoxide and VOCs (acetone, isoprene, ammonia, alcohols, sulfides) effective discrimination between the diseases mentioned above is possible, by capturing the relative sensor output signals from the detection of each of these biomarkers and analyzing them to reveal the distinct breath print for each disease. We focus here on an electronic olfaction device based on resistive gas sensing utilizing a small number, just four at a time, of metal-oxide sensors that are specifically sensitive to the biomarkers of interest.A single-scan skin testing device comprises an array of gas sensors, each of which satisfies the following stringent conditions: high sensitivity to the target gas, high selectivity, stable response over extended periods of time and rapid response. The concentration of a target gas over a selective sensor is quantified by measurement of the sensor resistance. We also present a novel wearable device interfacing with a smart phone for disease detection and monitoring. This device utilizes conducting polymer actuators, since conductive polymers exhibit a low operating potential (typically <2V), and a high mechanical strength. Quantitative medical diagnostics require simultaneous monitoring of multiple gases because markers are affected differently in different diseases and this device allows for continuous measurement of acetone for diabetes monitoring.
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Blunder, Stefan, Petra Pavel, Deborah Minzaghi i Sandrine Dubrac. "PPARdelta in Affected Atopic Dermatitis and Psoriasis: A Possible Role in Metabolic Reprograming". International Journal of Molecular Sciences 22, nr 14 (8.07.2021): 7354. http://dx.doi.org/10.3390/ijms22147354.
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Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors expressed in the skin. Three PPAR isotypes, α (NRC1C1), β or δ (NRC1C2) and γ (NRC1C3), have been identified. After activation through ligand binding, PPARs heterodimerize with the 9-cis-retinoic acid receptor (RXR), another nuclear hormone receptor, to bind to specific PPAR-responsive elements in regulatory regions of target genes mainly involved in organogenesis, cell proliferation, cell differentiation, inflammation and metabolism of lipids or carbohydrates. Endogenous PPAR ligands are fatty acids and fatty acid metabolites. In past years, much emphasis has been given to PPARα and γ in skin diseases. PPARβ/δ is the least studied PPAR family member in the skin despite its key role in several important pathways regulating inflammation, keratinocyte proliferation and differentiation, metabolism and the oxidative stress response. This review focuses on the role of PPARβ/δ in keratinocytes and its involvement in psoriasis and atopic dermatitis. Moreover, the relevance of targeting PPARβ/δ to alleviate skin inflammation is discussed.
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Haritha, Komeravelli, i Perumalla Nataraj. "Study of skin changes and associated diseases in pregnancy". International Journal of Research in Dermatology 4, nr 4 (25.10.2018): 586. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20184466.
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<p class="abstract"><strong>Background:</strong> Pregnancy accounts for profound changes like endocrinal, vascular, metabolic etc. The body adjust to these changes by compensating. Most changes are temporary but some may be permanent. Skin also undergoes changes and can be a cause of anxiety. Hence identification and management and counselling of these changes are important. Objective was to study the skin changes and associated diseases in pregnancy.</p><p class="abstract"><strong>Methods:</strong> A hospital based cross sectional study was carried out among 100 pregnant women who were selected as per eligibility criteria of the study over a period of one and half year. Those women having skin conditions were included in the present study.<strong></strong></p><p class="abstract"><strong>Results:</strong> Among both primigravida as well as multigravida women the most common condition was linea nigra i.e. 80.4% and 93.9% respectively. Breast changes were seen in 12.2% of the multigravida women and none in primi. Only 18 women were found to develop the specific dermatoses of pregnancy. Among them the most common dermatoses was Prurigo of pregnancy in 66.7% of the cases 5% had bacterial skin infections. 9% had viral skin infections. 16% had scabies. 14% had fungal skin infections and among them, Tinea versicolar was more common. 3% had angular stomatitis.</p><p class="abstract"><strong>Conclusions:</strong> Dermatoses of pregnancy were common in the study sample. They need proper attention in order to treat, and manage properly and at the same time it needs psychological counselling to relieve anxiety among pregnant women.</p>
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Murashkin, Nikolay N., Eduard T. Ambarchian, Roman V. Epishev, Alexander I. Materikin, Leonid A. Opryatin, Roman A. Ivanov i Daria S. Kukoleva. "Photodermatoses in Childhood". Current Pediatrics 20, nr 5 (7.11.2021): 360–69. http://dx.doi.org/10.15690/vsp.v20i5.2308.
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Photodermatoses is a heterogeneous group of diseases resulting from abnormal skin hypersensitivity to sunlight and presented as local or generalized rashes. Specific sensitivity of children's skin to ultraviolet is often the first sign or clinical symptom of photodermatosis. Abnormal photosensitivity can be represented by diverse group of primary idiopathic conditions or photo-mediated aggravation of existing dermatosis. Number of genetic genodermatoses, metabolic disorders and connective tissue diseases is also widely known. These conditions can manifest with photosensitivity associated to other extracutaneous clinical and laboratory features. Timely diagnosis of photosensitivity in childhood allows to minimize long-term complications associated with insufficient photoprotection.
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Annerino, Anthony, i Pelagia-Irene (Perena) Gouma. "Future Trends in Semiconducting Gas-Selective Sensing Probes for Skin Diagnostics". Sensors 21, nr 22 (13.11.2021): 7554. http://dx.doi.org/10.3390/s21227554.
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This paper presents sensor nanotechnologies that can be used for the skin-based gas “smelling” of disease. Skin testing may provide rapid and reliable results, using specific “fingerprints” or unique patterns for a variety of diseases and conditions. These can include metabolic diseases, such as diabetes and cholesterol-induced heart disease; neurological diseases, such as Alzheimer’s and Parkinson’s; quality of life conditions, such as obesity and sleep apnea; pulmonary diseases, such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease; gastrointestinal tract diseases, such as irritable bowel syndrome and colitis; cancers, such as breast, lung, pancreatic, and colon cancers; infectious diseases, such as the flu and COVID-19; as well as diseases commonly found in ICU patients, such as urinary tract infections, pneumonia, and infections of the blood stream. Focusing on the most common gaseous biomarkers in breath and skin, which is nitric oxide and carbon monoxide, and certain abundant volatile organic compounds (acetone, isoprene, ammonia, alcohols, sulfides), it is argued here that effective discrimination between the diseases mentioned above is possible, by capturing the relative sensor output signals from the detection of each of these biomarkers and identifying the distinct breath print for each disease.
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Mesjasz, Alicja, Marta Zawadzka, Maciej Chałubiński i Magdalena Trzeciak. "Is Atopic Dermatitis Only a Skin Disease?" International Journal of Molecular Sciences 24, nr 1 (3.01.2023): 837. http://dx.doi.org/10.3390/ijms24010837.
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Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coincidental exposure to similar environmental factors. However, it is also suspected that they are linked to the pathogenesis of AD through more complex genetic and immunological mechanisms, but these correlations remain less understood. It is of great need to seek explanations for the higher frequency of the number of cardiovascular, autoimmune, neurological, psychiatric, and metabolic disorders that have been observed in epidemiologic investigations among AD patients. Moreover, analysing the immunology of chronic inflammation and its correction, activation, or suppression may prevent the development of a variety of comorbidities. As comorbid diseases in patients diagnosed with AD may potentially go undetected, physicians should be aware of them.
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Wang, Xixuan. "Targeted Treatment of Common Human Diseases With Glutathione". Highlights in Science, Engineering and Technology 74 (29.12.2023): 209–14. http://dx.doi.org/10.54097/2d8e0368.
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Glutathione (GSH) is a typical medication and health product. Previous research has shown that GSH, which has substantial antioxidant activity, is involved in a number of crucial intracellular metabolic activities. By decreasing oxidative stress, disorders like tumors, alcoholic liver disease, and IRI can be somewhat improved. This research will examine the clinical management of heart, ocular, liver and skin illnesses, with GSH serving as the narrative focus. The association between coronary heart disease and oxidative stress was revealed by the fluorescence detection of GSH and OPA, and the amelioration of some coronary atherosclerosis by GSH was suggested. Additionally, GSH can successfully prevent surgical damage brought on by valve surgery and I/R and preserve the cardiac muscle during the procedure. For people with early cataracts, GSH eye drops are crucial, and they are more effective than oral vitamins and smoke tablets. GSH has been shown to significantly minimize problems in early and middle stage individuals with chronic hepatitis B. GSH is fairly developed in terms of skin conditions and aesthetics. Melasma can be reduced, whitened, and controlled through intravenous injection and oral means.
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Hunyadi, János. "The pathomechanism of the formation of various skin wounds". Bőrgyógyászati és Venerológiai Szemle 98, nr 6 (20.12.2022): 296–99. http://dx.doi.org/10.7188/bvsz.2022.98.6.1.
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Wounds can develop on our skin due to arterial and venous circulation disorders and metabolic diseases. The healing of injury is possible because our cells have a dualenergy supply system and can ensure tissue regeneration even without O2. The publication summarizes the defining elements and construction of the structures responsible for energy transformation. We point out the importance of the Hypoxia-Inducible Factor (HIF-1 alpha) in wound healing and the details of the causes of non-healing wounds.
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Hosthota, Abhineetha, Ishwarya U., Anila Sara Thampi, Supriya R., Chaganam Kavya, Chandan B. C. i Bhavana Venumbaka. "Association of metabolic syndrome and insulin resistance in papulosquamous diseases". International Journal of Research in Dermatology 9, nr 4 (26.06.2023): 189–95. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20231826.
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Background: Metabolic syndrome (MetS), insulin resistance (IR) and papulosquamous diseases with shared pathophysiology leads to conglomeration of risk factors of non-communicable diseases like cardiovascular disease (CVD) and type 2 diabetes (T2D) causing high mortality worldwide. The objective is to study the association of MetS and IR in papulosquamous diseases. Methods: It is a hospital-based case-control study conducted on 200 age-sex matched cases and controls with consent. Subjects were administered a pre-validated questionnaire, diagnosis of papulosquamous diseases was based on clinical examination and skin biopsy. MetS was diagnosed based on national cholesterol education program's- adult treatment plan iii with Asian modification for abdominal circumference criteria. Fasting serum insulin levels (FI) was used as a surrogate marker of IR. Results: Mean serum HDL- C level was low and statistically significant (p=0.017). Mean fasting plasma glucose level was significantly higher in patients (p=0.008). Mean FI level was significant between cases and controls (p=0.013). IR was found in 76% of cases which was significantly higher than in controls (p<0.05). IR was highest in psoriasis 29% followed by LP 22%, PRP 19%, and LS 6% which was statistically significant (p<0.05). MetS was mostly found in psoriasis (17%), LP (9%) and least in PRP, LS. Conclusions: This study intends clinicians to do periodic MetS and IR evaluation in papulosquamous diseases. Thus, subclinical cases of non-communicable diseases can be detected and potential co-morbidities can be prevented.
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Tlish, M. M., E. B. Popovskayа, N. L. Sycheva, N. V. Sorokina i F. A. Psavok. "ASSOCIATED PATHOLOGY: CLINICAL ОBSERVATION". Vestnik dermatologii i venerologii 93, nr 4 (9.08.2017): 66–73. http://dx.doi.org/10.25208/0042-4609-2017-93-4-66-73.
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The article analyzes the literature on polymorbidity of immune dermatoses. They confirm the possibility of combining with each other immune diseases, due to the presence of immune and metabolic abnormalities that are characteristic for the majority of chronic dermatoses and may indicate the possibility of combining several nosology. We present 2 clinical cases polymorbidity. In the first case — a combination demonstrated in one patient planus, idiopathic atrophoderma Pasini — Pierini and multi-colored lichen. In the second case detected combination of 4 kinds of dermatological diseases — horny eczema, psoriasis vulgaris, scleroderma, and rosacea. Patients underwent complex clinical examination and histomorphological examination of skin biopsies. The presented clinical cases demonstrate the possibility of a combination of several skin diseases in one patient with common etiopathogenic mechanisms
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Zhai, Zili, Takeshi Yamauchi, Sarah Shangraw, Vincent Hou, Akiko Matsumoto i Mayumi Fujita. "Ethanol Metabolism and Melanoma". Cancers 15, nr 4 (16.02.2023): 1258. http://dx.doi.org/10.3390/cancers15041258.
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Malignant melanoma is the deadliest form of skin cancer. Despite significant efforts in sun protection education, melanoma incidence is still rising globally, drawing attention to other socioenvironmental risk factors for melanoma. Ethanol and acetaldehyde (AcAH) are ubiquitous in our diets, medicines, alcoholic beverages, and the environment. In the liver, ethanol is primarily oxidized to AcAH, a toxic intermediate capable of inducing tumors by forming adducts with proteins and DNA. Once in the blood, ethanol and AcAH can reach the skin. Although, like the liver, the skin has metabolic mechanisms to detoxify ethanol and AcAH, the risk of ethanol/AcAH-associated skin diseases increases when the metabolic enzymes become dysfunctional in the skin. This review highlights the evidence linking cutaneous ethanol metabolism and melanoma. We summarize various sources of skin ethanol and AcAH and describe how the reduced activity of each alcohol metabolizing enzyme affects the sensitivity threshold to ethanol/AcAH toxicity. Data from the Gene Expression Omnibus database also show that three ethanol metabolizing enzymes (alcohol dehydrogenase 1B, P450 2E1, and catalase) and an AcAH metabolizing enzyme (aldehyde dehydrogenase 2) are significantly reduced in melanoma tissues.
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KUGLER, Tatyana, i Gennady TARADIN. "HELICOBACTER AND HEPATOBILIARY DISEASES: UPDATE 2023". Arquivos de Gastroenterologia 60, nr 2 (czerwiec 2023): 271–81. http://dx.doi.org/10.1590/s0004-2803.202302023-15.
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ABSTRACT Helicobacter Pylori (H. pylori) is one of the main infectious causes of gastroduodenal diseases, however, its role in developing different extragastric diseases has been proven. The possible involvement of H. pylori in the pathogenesis of cardiovascular, metabolic, neurodegenerative, skin, and hepatobiliary diseases is suggested. The bacterium has been found in tissue samples from the liver, biliary tract, and gallstones of animals and humans. However, the role of H. pylori infection in the pathogenesis of liver and biliary diseases has not been finally established. The histopathological confirmation of the positive effect of H. pylori eradication is needed. In addition, there are discussions on the clinical significance of other Helicobacter species. The review presents the data available for and against the involvement of H. pylori in hepatobiliary disease development and progression.
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Giniyatova, Irina, Anna Amerkhanova, Tatyana Vygovskaya, Bulat Gilmutdinov i Julia Tazetdinova. "Clinical and metabolic efficiency of physiobalnotherapy of psoriasis". Fizioterapevt (Physiotherapist), nr 2 (1.04.2020): 64–69. http://dx.doi.org/10.33920/med-14-2004-09.
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The results of the clinical and metabolic efficacy of sulfide balneotherapy and laser blood irradiation in 90 patients with common vulgar psoriasis are presented. It has been established that a treatment complex based on hydrogen sulfide baths in combination with intravenous laser blood irradiation helps to reduce initially elevated levels of pro-inflammatory cytokines with an increase in anti-inflammatory cytokines, leads to inhibition of peroxide metabolism with an increase in antioxidant enzyme activity, and has an anti-inflammatory and antioxidant effect with a significant improvement in the clinical picture diseases and regression of psoriatic elements on the skin in 86% of cases
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Knotkova, Z., A. Musilova, K. Pinterova i Z. Knotek. "Plasma protein electrophoresis in green iguanas (Iguana iguana) suffering from hepatic, renal and inflammatory skin diseases". Veterinární Medicína 64, No. 6 (20.06.2019): 271–79. http://dx.doi.org/10.17221/5/2019-vetmed.
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The goals of this study were to evaluate electrophoretograms in green iguanas suffering from hepatic, renal and inflammatory skin diseases. Plasma samples were obtained from 14 green iguana patients. The diagnosis was based on clinical examination, evaluation of biochemical and haematological profiles or histopathological examination. Agarose gel electrophoresis was performed using an automated HYDRASYS system. A decrease in the albumin/globulin ratio was observed in 11 out of 14 patients (three out of four patients with liver failure, one out of one patient with chronic renal insufficiency and suspected hepatopathy, two out of two patients with chronic interstitial nephritis, four out of five patients with chronic renal insufficiency and one out of two patients with dermatitis). The alpha globulin fraction was elevated in 1 out of 14 patients (patient with dermatitis). The fraction of beta globulins was increased in 8 out of 14 patients (two out of four patients with liver diseases, four out of eight patients with various forms of renal failure and two out of two patients with inflammatory skin diseases). Increased gamma globulin levels were observed in 4 out of 14 patients (one out of four patients with impaired function of the liver, two out of eight patients with renal diseases and one out of two patients with dermatitis). Changes in the electrophoretograms of green iguanas are not disease-specific, but in conjunction with other biochemical blood tests the electrophoresis of plasma proteins may be a useful indicator in the diagnosis of metabolic and infectious diseases and in the monitoring of disease progress.
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Buquicchio, Rosalba, Caterina Foti i Maria Teresa Ventura. "The Psoriasis Pathogenesis and the Metabolic Risk". Open Dermatology Journal 12, nr 1 (31.07.2018): 70–79. http://dx.doi.org/10.2174/1874372201812010070.
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Summary Psoriasis is a multifactorial disease that can be related to genetic, environmental and immunological causes. Therefore, not only a single factor but different aspects contribute to the onset of the disease, varying from individual to individual. It would be characterized by an abnormal proliferation and differentiation of keratinocytes, mediated by a dysregulation in the auto-immune T cell response in which several cytokines participate, including Interleukin (IL)-17, IL-17A, IL-12, IL-22, IL-23. These cells and cytokines are responsible for the aggression on skin cells, inflammation and accelerated reproduction of the cells of the epidermis. Due to the chronic inflammation, psoriasis is frequently associated with other concomitant non-dermatological morbid conditions such as arthropathy which can be complicated by a disabling evolution. Psoriasis is also frequently associated with comorbidities such as Cardiovascular Diseases (CVD), hyperlipidemia, diabetes and obesity. The knowledge of common inflammatory pathways and of the potential links between psoriasis and other diseases should encourage dermatologists to a multidisciplinary approach to psoriasis and to an optimal management also in the light of new therapeutic possibilities.
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Zindancı, Ilkin, Ozlem Albayrak, Mukaddes Kavala, Emek Kocaturk, Burce Can, Sibel Sudogan i Melek Koç. "Prevalence of Metabolic Syndrome in Patients with Psoriasis". Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/312463.
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Background. Psoriasis is a chronic inflammatory skin disorder in which proinflammatory cytokines including IL-6 and TNF-αincrease both locally and systematically. It is thought that chronic inflammation results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis, peripheral insulin resistance, hypertension, and type 2 diabetes. Our aim was to investigate the prevalence of metabolic syndrome in patients with psoriasis vulgaris.Methods. Study consisted of 115 plaque-type psoriasis patients and 140 healthy individuals. Data including body weight, height, waist circumference, body-mass index, and arterial blood pressure were collected. Fasting blood glucose, triglyceride, and HDL levels were determined. International Diabetes Federation Criteria for Metabolic Syndrome and Insulin Resistance were used for evaluating patients with metabolic syndrome and diabetes.Results. Compared to the control group, metabolic syndrome, diabetes mellitus, and hypertension were found to be higher in psoriasis patients. Metabolic syndrome was increased by 3-folds in psoriasis patients and was more prevalent in women than in men. It was determined that the prevalence of metabolic syndrome was higher in psoriasis patients after the age of 40. Metabolic syndrome was not related to smoking, severity of psoriasis, and duration of disease.Conclusions. Our findings suggest that psoriasis preconditions occurrence of a group of diseases such as diabetes mellitus, hypertension, and metabolic syndrome. For this reason, patients with psoriasis should be treated early and they should be followed with respect to metabolic diseases.
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Annerino, Anthony, i Perena Gouma. "Gas-Selective Semiconducting Oxide Nanowires from Novel Processing Methods". ECS Meeting Abstracts MA2022-01, nr 52 (7.07.2022): 2132. http://dx.doi.org/10.1149/ma2022-01522132mtgabs.
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Presented here are sensor nanomaterials that can be used for the skin-based gas “smelling” of disease. Skin testing may provide rapid and reliable results, using specific “fingerprints” or unique patterns for a variety of diseases and conditions. These can include metabolic diseases, such as diabetes and cholesterol-induced heart disease; neurological diseases, such as Alzheimer’s and Parkinson’s; quality of life conditions, such as obesity and sleep apnea; pulmonary diseases, such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease; gastrointestinal tract diseases, such as irritable bowel syndrome and colitis; cancers, such as breast, lung, pancreatic, and colon cancers; infectious diseases, such as the flu and COVID-19; as well as diseases commonly found in ICU patients, such as urinary tract infections, pneumonia, and infections of the blood stream. Focusing on the most common gaseous biomarkers emitted from human skin, which are nitric oxide and carbon monoxide, and certain abundant volatile organic compounds (acetone, isoprene, ammonia, alcohols, sulfides), it is argued here that effective discrimination between the diseases mentioned above is possible by capturing the relative sensor output signals from the detection of each of these biomarkers and identifying the distinct gaseous “fingerprint” of each disease with the presented nanomaterials synthesized by novel processing methods.
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Tamrazova, Olga B., Nataliya F. Dubovets, Anait V. Tamrazova i Sergey P. Seleznev. "Role of emollients in the prevention of skin diseases in young children". Meditsinskiy sovet = Medical Council, nr 1 (21.03.2021): 158–66. http://dx.doi.org/10.21518/2079-701x-2021-1-158-166.
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Epidermis plays an important role in protecting the body from negative environmental influences. The horny layer plays a special role in carrying out these functions. Skin defense mechanisms are multistage and include 5 protective barriers responsible for maintaining the integrity and performing the main functions of the skin. The first one is a microbial barrier – determined by commensal flora which prevents contamination of pathogenic microorganisms; the second one is a physical barrier preventing mechanical skin damage, penetration of allergens and microorganisms; the third one is a chemical barrier achieved by forming pH and components of natural moisturizing factor as well as epidermal lipids; the fourth one – immune barrier – Langerhans cells, tissue basophils, lymphocytes etc.;the fifth is the neurosensory barrier – numerous nerve endings transmitting signals of skin integrity damage and controlling metabolic processes and homeostasis maintenance. Epidermal barrier of newborns and infants is imperfect and differs in its structure and functional activity from that of adults. Children’s skin is prone to excessive dryness, irritation, allergic reactions and inflammation. For young children, it is very important to minimize the risk of these manifestations. Individual selection and use of emollients in the basic care of infants promotes the functional stability of five protective «frontiers» of the epidermal barrier: prevents skin damage when exposed to unfavorable environmental factors, reduces TEWL, supports the normal microbiome, has antipruritic and anti-inflammatory action. Modern emollients restore the hydrolipidic layer of the epidermis and prevent the development of dermatitis and skin infection in children. An important role when choosing an emollient is played by its texture, which can be represented by a lotion, cream, balm, ointment. Chemically, creams, lotions and balms are emulsions, i.e. they consist of two immiscible components – fat (oil) and water. In this case, one of the components is in the other in the form of tiny droplets. Most skin diseases faced by young children are related to the integrity of the epidermis, which is why daily care should be primarily focused on protecting the skin barrier
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Dhume, Manjeeta Mahesh Sinai. "Named Cells and Bodies in Blood, Skin and Neural Diseases Along with Metabolic & Storage Disorders". International Journal of Dentistry Research 8, nr 2 (30.08.2023): 40–45. http://dx.doi.org/10.31254/dentistry.2023.8204.
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The visual specialty of oral pathology guides a pathologist into the world of minute details in complex tissues. When we see certain sick cells or bodies, we can become locked in a state of flux because our eyes are more used to seeing normal morphology in cells and structures. Despite the fact that they may be misleading in appearance, they help the pathologist make a diagnosis because they are pathognomonic for a number of diseases and ailments. Hence, the present article is an attempt to compile different histopathological bodies seen in various diseases associated with blood, skin and neural diseases along with metabolic and storage disorders with special emphasis on pathogenesis, microscopic and stains used to highlight features of the same.
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Wagner, Sonia, Marta Gómez de Cedrón, Joaquín Navarro del Hierro, Diego Martín-Hernández, María de las Nieves Siles, Susana Santoyo, Laura Jaime, Diana Martín, Tiziana Fornari i Ana Ramírez de Molina. "Biological Activities of Miracle Berry Supercritical Extracts as Metabolic Regulators in Chronic Diseases". International Journal of Molecular Sciences 24, nr 8 (9.04.2023): 6957. http://dx.doi.org/10.3390/ijms24086957.
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Synsepalum dulcificum (Richardella dulcifica) is a berry fruit from West Africa with the ability to convert the sour taste into a sweet taste, and for this reason, the fruit is also known as the “miracle berry” (MB). The red and bright berry is rich in terpenoids. The fruit’s pulp and skin contain mainly phenolic compounds and flavonoids, which correlate with their antioxidant activity. Different polar extracts have been described to inhibit cell proliferation and transformation of cancer cell lines in vitro. In addition, MB has been shown to ameliorate insulin resistance in a preclinical model of diabetes induced by a chow diet enriched in fructose. Herein, we have compared the biological activities of three supercritical extracts obtained from the seed—a subproduct of the fruit—and one supercritical extract obtained from the pulp and the skin of MB. The four extracts have been characterized in terms of total polyphenols content. Moreover, the antioxidant, anti-inflammatory, hypo-lipidemic, and inhibition of colorectal cancer cell bioenergetics have been compared. Non-polar supercritical extracts from the seed are the ones with the highest effects on the inhibition of bioenergetic of colorectal (CRC) cancer cells. At the molecular level, the effects on cell bioenergetics seems to be related to the inhibition of main drivers of the de novo lipogenesis, such as the sterol regulatory element binding transcription factor (SREBF1) and downstream molecular targets fatty acid synthase (FASN) and stearoyl coenzyme desaturase 1 (SCD1). As metabolic reprograming is considered as one of the hallmarks of cancer, natural extracts from plants may provide complementary approaches in the treatment of cancer. Herein, for the first time, supercritical extracts from MB have been obtained, where the seed, a by-product of the fruit, seems to be rich in antitumor bioactive compounds. Based on these results, supercritical extracts from the seed merit further research to be proposed as co-adjuvants in the treatment of cancer.