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Muir, Timothy J. "Mechanisms and phylogenetic breadth of urea-induced hypometabolism". Oxford, Ohio : Miami University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1247688904.
Pełny tekst źródłaTweedy, Maureen P. "Metabolic Syndrome and Psychosocial Factors". Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11005/.
Pełny tekst źródłaTweedy, Maureen P. Guarnaccia Charles Anthony. "Metabolic syndrome and psychosocial factors". [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11005.
Pełny tekst źródłaBishop, T. "Living at a snail's pace : the cellular basis of metabolic depression". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596665.
Pełny tekst źródłaWang, Yijie, i 王怡洁. "Associations among type A and type D personalities, metabolicsyndrome, and anxiety/depression". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47849496.
Pełny tekst źródłapublished_or_final_version
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Silveira, Lilian Cristina da. "Reorganização estrutural e metabólica do tecido cardíaco associada à dormência e jejum sazonal em lagartos teiú Tupinambis merianae". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-13052011-100148/.
Pełny tekst źródłaThe structural and metabolic flexibility of cardiac response to a variable physiological demand is notable. During seasonal dormancy, interruption of feeding together with inactivity and reduced heart beating, cause a large decrease of demand which probably brings about structural and metabolic heart tissue reorganization. These aspects were studied during the annual cycle in young tegu lizards Tupinambis merianae to investigate the hypothesis of seasonal changes of the heart capacities given by adjustments of tissue mass, structure and composition, by regulation of flux of substrates in the pathways of energy production, and by changes in the composition of fatty acids of tissue membranes. Groups of animals were killed in selected phases during the first year cycle of young tegus and after a 20 days fasting period during spring activity. Heart ventricle was removed and weighed and a tissue sample was collected and transfered to fixative solution, being used to obtain tissue slices of 10μm width for histological analysis with stereological tools. The remaining tissue was cut and split into aliquots, frozen in liquid N2 and stored at -80ºC. Later, the aliquots were used to assess the content of water, total and soluble proteins, and total lipids, by standard assays, the maximum activity of enzymes by spectrophotometry, and neutral and polar fatty acids profiles by gas chromatography. In early fall, the relative mass ventricle is 0.16%, and 31% increased in late fall, when the spongy myocardium appears dense and with few lacunar spaces which area corresponds to 8% of slice total área. During dormancy, the ventricle mass increases further 29%, decreasing to values of late fall during early arousal. After food intake, mass ventricle is again increased together with a small increase of the lacunar spaces, which appear highly expanded later in spring (29% of the total area), when tissue mass is 0,24% increased in relation to early fall. Unlike dormancy, fasting during spring caused a decrease of 19% of the ventricle mass. The cardiomyocytes density in the spongy layer is 37% decreased during dormancy while estimated cell volume is 52% increased, in relation to spring activity. There was no seasonal changes in the content of water and proteins in the groups analysed, except to a tendency to increase in the water content during dormancy, and to decrease in the soluble proteins in early arousal and in fasted animals. Myofibrillar protein is lower during fall and dormancy in relation to spring, increasing soon in early arousal after water intake. Total lipids decrease in the tissue during dormancy in relation to late fall by similar proportion than after fasting during spring. The glycolytic enzymes PK e LDH are unchanged during the year cycle, whereas the mitochondrial CS shows a tendency to increase, and HOAD, a β-oxidation enzyme, is decreased during dormancy and early arousal, in relation to fall. Unlike, PK and CS are decreased, while HOAD is unchanged after a period of fasting during spring. Fatty acids (FA) profiles of neutral lipids suggest that unsaturated FA are preferentially mobilized during dormancy and arousal, whereas all FA would be equally used during spring fasting. FA of polar lipids are remarkably constant during the year, suggesting that membrane FA in the heart tissue are not generally affected by season, and thus, results do not support a predominant role played by compositional changes of membranes in metabolic depression in the tegu. In addition, the otherwise distinct findings with hibernating mammals suggest that changes of FA composition in these animals would be an adaptation to the low body temperature of torpor, rather than mechanism of metabolic inhibition. Regression analysis indicate significant relationships of C18:1n-9, C22:5n-6, and C22:6n-3 contents as a function of body mass in young tegus, and changes in the allometric patterns are consistent with a putative relationship between these FA levels and the scaling of mass specific metabolic rates of young tegus during the year cycle.
Hoopes, Lisa Ann. "Metabolic and thermoregulatory capabilities of juvenile steller sea lions, Eumetopias jubatus". [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1390.
Pełny tekst źródłaOlvera, Anna E. "Diabetes in Latinas : depression, metabolic control and the roles of acculturation and social support". Access to abstract only; dissertation is embargoed until after 12/20/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=135.
Pełny tekst źródłaSharovsky, Lilian Lopes. "Análise de sintomas depressivos e ansiosos nas variáveis clínicas da síndrome metabólica". Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-22062010-131123/.
Pełny tekst źródłaObjective: Metabolic Syndrome (MetS) has been associated to depression sintomatology by means of the hypothalamus-pituitary-adrenal axle activation and consequent alterations of the cortisol levels. The objective of this study is to explore the association of depressive and anxiety symptoms severity with MetS clinical variables and salivary cortisol. Methods: We studied 136 consecutive ambulatory patients (aged= 55,37±7,62), n= 69 women, who presented MetS criteria according to the National Cholesterol Education Program Revised (NCEP-ATPIII-R). At the first visit they all completed a social-demographic questionnaire.Then, we assessed depressive symptoms by Beck Depression Inventory (BDI) and anxiety symptoms by Hamilton Anxiety Rating Scale (HARS). Salivary cortisol was assessed at 7:00h A.M. Results: We observed that the higher the intensity of the depressive symptoms by the BDI, the higher the glycemia value (p=0,01) in the female group (p 0,001). The same correlation was observed between HARS and glycemia (p=0,001) and HARS and genre (p=0,02). No correlation between depressive and anxiety symptoms with the other MetS clinical variable was found. The correlation was also positive between HARS and BDI. No correlation between depressive and anxiety symptoms with salivary cortisol was found. Furthermore, there was no association between cortisol and MS clinical variables. Conclusions: In the studied population, a presence of a higher intensity of depressive and anxiety symptoms was verified in the female group. We observed that, in this group, both the BDI and HARS value was explained by an increased fasting glucose. There was neither a correlation between depressive and anxiety symptoms and salivary cortisol
Kemp, David E. "Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity". Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223.
Pełny tekst źródłaEstrada, Christina M. "The Impact of Obesity and Estrogen on the Brain and Metabolic Function in Female Rats". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535378499166638.
Pełny tekst źródłaSakurai, Masashi. "Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder". Kyoto University, 2020. http://hdl.handle.net/2433/259732.
Pełny tekst źródłaWord, James Mabry. "Physiological adjustments to aestivation and activity in the cocoon-forming frogs Cyclorana platycephala and Cyclorana maini". University of Western Australia. School of Animal Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0254.
Pełny tekst źródłaGenuario, Kimberly. "Possible Moderators of the Relationship Between Health Beliefs and Adherence and Metabolic Control in Adolescents with Type 1 Diabetes". Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1512562500418142.
Pełny tekst źródłaRibeiro, Renata Perfeito. "Prevalência da síndrome metabólica entre trabalhadores das equipes médica e de enfermagem de um hospital do Paraná e sua associação com estresse ocupacional, ansiedade e depressão". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/83/83131/tde-13062013-154813/.
Pełny tekst źródłaAmong the diseases related to work activities performed in healthcare are those related to the risks or burdens that workers are subject, including the metabolic syndrome, stress and anxiety and depression. The hypotheses were (H1) there is an association between occupational stress presented by the employees of the medical and nursing staff working in hospitals and the Metabolic Syndrome and (H2) there is an association between anxiety and depression presented by workers in medical and nursing teams working in hospitals and Metabolic Syndrome. The objective of this research was to identify the prevalence of metabolic syndrome among workers in medical and nursing teams and its association with occupational stress anxiety and depression. The theoretical approach in this research was guided in Demand Mode - Control proposed by Alves et al. (2004), Theorell (1996) and Karasek and Theorell (1996) to analyze the relationship between stress and work and conceptual assumptions of Chandola Brunner and Marmot (2006) on the predictor Metabolic Syndrome and also in designing o Botega et al. (1998) on anxiety and depression related to work. This is a descriptive correlational study was conducted with 260 workers at the University Hospital of Londrina, with data collection taking place between the months of August 2011 to August 2012. The instruments used for data collection were the Job Stress Scale (JSS) at the Hospital Anxiety and Depression Scale (HADS) questionnaire with sociodemographic and occupationa characteristics of workers and the evaluation of the variables for the diagnosis of metabolic syndrome. The data were processed using the Statistical Package for Social Sciences (SPSS) version 15.0. Nursing workers represented 86.9% of the sample of this research and the doctors 13.1%, there was a predominance of female participants (75.8%), the age of the workers presented a range 23-66 years, 66, 1% were married, 41.5% complete third degree, 25.0% had post-graduate, the salary was among 2.000,00 to 3.000,00 (33.8%), 2% work up to 42 hours per week, 23 5% up to 60 hours and 22.0% over 60 hours, 96.9% eat meat, 95.8% and vegetables 66.5% do not exercise, smoke 20.0% and 40.8 % ingest alcoholic beverages, 35.4% with metabolic syndrome, 72.7% are not exposed to stress, 16.2% have high exposure and 11.2% intermediate exposure to stress, 69.2% had anxiety, 22% possible anxiety, probable anxiety 8.8%, 82.7% had depression, 12.7% possible depression and 4.6% probable depression. There is no significant association between the variables present the Metabolic Syndrome and belong to the nursing or medical staff, present the Metabolic Syndrome, and physical activity presenting Metabolic Syndrome and have the habit of eating meat, presenting Metabolic Syndrome and have the habit of smoking, presenting stress and belong to the medical or nursing staff, presenting Metabolic Syndrome, eating meat and belong to the nursing staff presenting Metabolic Syndrome, smoking and belong to the nursing staff, presenting Metabolic Syndrome, smoking and belong to the medical staff, presenting Metabolic Syndrome, alcoholic beverages and belong to the nursing staff, presenting Metabolic Syndrome, alcoholic beverages and belong to the medical staff, Metabolic Syndrome and present physical activity and belong to the medical team, presenting stress and belong to the nursing staff or medical, presenting anxiety and belong to the teams medical or nursing, presenting depression and belong to the medical or nursing staff. There is a significant association between the variables: present the Metabolic Syndrome and drinking alcohol, present the Metabolic Syndrome and stress, stress and provide an income wage worker from 2000.00 to 3000.00, presenting the Metabolic Syndrome and physical activity in nursing staff, presenting Metabolic Syndrome and anxiety The internal consistency of the instruments was (α=0.786) and (α=0.773).
Herva, A. (Anne). "Depression in association with birth weight, age at menarche, obesity and metabolic syndrome in young adults:the Northern Finland 1966 Birth Cohort Study". Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514283284.
Pełny tekst źródłaTiivistelmä Depressio on yleinen mielenterveyden häiriö suomalaisväestössä. Depression taustalla on monia biologisia, psykologisia ja sosiaalisia tekijöitä. Tämän tutkimuksen tavoitteena oli tutkia depressiota selvittäen, onko syntymäpainolla, menarkeiällä, lihavuudella ja metabolisella oireyhtymällä yhteyttä depressioon Pohjois-Suomen vuoden 1966 syntymäkohorttiaineistossa. Tutkimusaineistoon kuului alun perin 12058 elävänä syntynyttä lasta. Tietokantaan oli jo aiemmin kerätty aineistoa syntymään ja primaariperheeseen liittyen. Kohortin jäsenten ollessa 14-vuotiaita tehtiin seurantatutkimus postikyselynä ja 31-vuotiaana tehtiin sekä postikysely että kliininen tutkimus. Tiedot menarkeiästä kerättiin 31-vuotispostikyselystä, paino- ja pituustiedot sekä 14- ja 31-vuotispostikyselyistä että kliinisen tutkimuksen tiedoista. Kliininen tutkimus sisälsi tiedot myös keskivartalolihavuuden ja metabolisen oireyhtymän määrittämiseksi. 31-vuotispostikyselyssä depressio-oireita kysyttiin HSCL-25 -oirekyselyllä; lisäksi kysyttiin, oliko lääkäri todennut aiemmin masennusta sekä oliko tutkittavilla käytössä masennuslääkkeitä. Naisilla, joiden syntymäpaino ja ponderaali-indeksi (syntymäpainon ja pituuden suhdetta kuvaava indeksi, kg/m3) oli korkea, depressio-oireiden riski 31-vuotiaana mitattuna HSCL-25:lla oli suurentunut verrattuna naisiin, joilla oli normaali syntymäpaino ja ponderaali-indeksi. Miehillä, joilla oli hyvin alhainen ponderaali-indeksi kuuluen alimpaan 5 % ryhmään, riski lääkärin toteamaan masennukseen oli suurentunut. Naisilla, joiden menarkeikä oli 16-vuotta tai myöhemmin, riski depressio-oireiden esiintyvyyteen, depressiolääkkeiden käyttöön ja lääkärin toteaman depression esiintyvyyteen oli suurentunut verrattuna naisiin, joiden menarkeikä oli 12–15-vuotta. Lihavuus 14-vuotiaana lisäsi masennusoireiden riskiä mitattuna HSCL-25:lla sekä 31-vuotiailla miehillä että naisilla. Naisilla, jotka olivat lihavia sekä 14- että 31-vuotiaana, masennusoireiden riski oli suurentunut. Naisilla, joiden paino oli noussut, masennuslääkkeitten käyttö oli yleisempää verrattuna naisiin, joilla paino oli pysynyt normaalina. Keskivartalolihavuus oli miehillä yhteydessä suurentuneeseen depressio-oireiden ja lääkärin toteaman masennuksen riskiin, ja he käyttivät yleisemmin masennuslääkkeitä verrattuna miehiin ilman keskivartalolihavuutta. Naisilla keskivartalolihavuus ei ollut yhteydessä masennukseen. Metabolinen oireyhtymä ei ollut yhteydessä masennukseen. Tulokset osoittavat korkean syntymäpainon, myöhäisen menarkeiän ja nuoruusiän lihavuuden sekä painon nousun lisäävän masennusriskiä 31-vuotiailla naisilla, 31-vuotiailla miehillä nuoruusiän lihavuus sekä keskivartalolihavuus olivat yhteydessä suurentuneeseen masennusriskiin
Ortega, Vila Yolanda. "Impacte de la depressió i/o l'ansietat en l'aparició d'esdeveniments cardiovasculars en una cohort afectada de síndrome metabòlica. Projecte strex: cinc anys de seguiment". Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/403203.
Pełny tekst źródłaObjetivos: Determinar la prevalencia del Sindrome Metabólico(SM) y sus fenotipos. Determinar incidencia de eventos cardiovasculares(ECV) globalmente y según ansiedad/depresión, índice socioeconómico, fenotipos SM. Evaluar el impacto del estrés (medido como ansiedad, depresión, estado socioeconómico) y fenotipos de SM sobre la incidencia de ECV y mortalitat global(MG). Identificar factores independientes que determinen mayor incidencia de ECV y MG en población SM. Diseño: Estudio cohortes Ámbito: Atención Primaria. Sujetos: personas(35-75años) con criterios SM, sin ECV previo(2009). Clasificación por 16 fenotipos SM[criterios NCEP-ATPIII: HTA(presión arterial),COL(colesterol), TG(triglicéridos), PC(perímetro cintura),GLU(anomalías glucídicas)]. Variable principal: Incidencia(5 años) de ECV y MG. Variables predictoras: edad, sexo, fenotipos SM, índice socioeconómico. Resultados: N=401.743personas con SM (17,2% de la población catalana), 51,1%hombres, edad media±DE: 60,1+9,9años. Registramos 8,7%de depresión, 16,0% de ansiedad y 3,8%ambos. 14,5%consumen antidepresivos y 20,8% ansiolíticos.Los fenotipos SM predominantes: HTA+COL+TG+GLU; HTA+COL+GLU; HTA+COL+TG y HTA+PC+GLU. La obesidad no es vinculante al riesgo de ECV. En hombres predominan: hipertensión/HDL-colesterol bajo/hipertrigliceridemia. En mujeres: Obesidad/hipertrigliceridemia/glucemia alterada. Los fenotipos SM con más ECV, reunen 3-4criterios. Mayor número de criterios no determinan mayor riesgo de ECV La ansiedad predomina en SM(21,1%) que reune obesidad/HDL-colesterol bajo/ glucemia alterada. La depresión predomina en SM(10,9%) que contiene: hipertensió arterial/obesitat/hipertrigliceridèmia. Los ECV siguen, globalment, la misma distribución que las alteraciones del ánimo: a más ansiedad y depresión, más eventos. El 20,5% de la población catalana con SM se agrupa en áreas rurales, entre urbanas, predomina Urbana-2(21,7%). Las urbanas más dispares socioeconómicament, tienen más ECV. En rural y Urbana5, se dan más casos de cardiopatia isquémica. Todas las variables son predictivas respecto la incidencia de ECV a cinco años. La MG viene determinada por: edad, sexo masculino, tabaquismo y presión de pulso elevada. Discusión: Las personas con SM y alteraciones anímicas necesitan mayor atención/ intervención para minimizar su riesgo de ECV.
Objectives: To determine the prevalence of Metabolic Syndrome(MetS) and its phenotypes. To determine the incidence of cardiovascular events(CVE) globally and according to anxiety/depression, socioeconomic index and MetS phenotypes. Assess the impact of stress (measured anxiety, depression, socioeconomic status) and MetS phenotypes, on the incidence of CVE and overall mortality(OM). Identify independent factors determining higher incidence of CVE/OM from all causes in people with MetS. Design: Cohort study Ambit: Primary Care. Subjects: People(35-75 years) fulfilling MetS criteria, without CVE at the start(2009). Condisering 16 MetS phenotypes[NCEP-ATPIII criteria:HBP(high blood pressure), CHO(cholesterol),TG(triglycerides),WC(waist-circumference),GLU(glucose abnormalities)]. Primary outcomes were the incidence of CVE and OM(5years). Interest variables were: age, gender, MetS phenotype, socioeconomic index. Results: 401,743people with MetS (17.2% of the Catalan population), 51.1% men, mean age60,1+9.9years. We registered 8.7%depression, 16.0%anxiety and 3.8% both. MetS dominant phenotypes: CHO+HBP+TG+GLU; CHO+HBP+GLU; HBP+CHO+TG and HBP+WC+GLU. The WC criterion is not closely associated to event risk. In men predominate: hypertension/lowHDL-cholesterol/ hypertriglyceridemia. In women, obesity/hypertriglyceridemia/impaired glucose. The MetS phenotypes with more CVE, collect three/four criteria. Greater number of criteria do not determine increased risk of CVE. Anxiety is more frequent in the MetS (21.1%) which includes obesity/low HDL-cholesterol/impaired glucose. Depression predominates in the MetS(10.9%) containing the criteria hypertension/obesity/hypertriglyceridemia. The events remain, overall, the distribution in mood disorders: more anxiety and depression, more events. 20.5% of the Catalan population with MetS groups in rural areas; and in the urban, predominantly(21.7%) in urban-2. More socioeconomically diverse urban areas have the highest rate of CVE. In rural and urban-5, there are more cases of ischemic heart disease. All variables are predictive regarding the CVE incidence in five years. The overall mortality rate is determined by age, male sex, smoking and highest pulse pressure. Discussion: People with MetS and mood disorders require greater attention/ intervention to minimize the risk of CVE
Zeugmann, Sara [Verfasser]. "Inflammation, metabolic syndrome, & early life stress in major depression : an investigation into the mind-body connection of affective disorders / Sara Zeugmann". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071088831/34.
Pełny tekst źródłaMaripuu, Martin. "Hypocortisolism in recurrent affective disorders". Doctoral thesis, Umeå universitet, Psykiatri, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112824.
Pełny tekst źródłaChampaigne, Lorraine Anne. "The role of marital distress, parental and child depression, family functioning and health care behaviors in treatment adherence and metabolic control among adolescents with diabetes". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ57028.pdf.
Pełny tekst źródłaEl, Asmar Khalil. "Predictive Power of Early Weight-Gain on Later Weight-Gain and Metabolic Syndrome in Depressed Patients Treated with Antidepressants : Findings from the METADAP Cohort". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS541/document.
Pełny tekst źródłaIn this dissertation we have studied the relationship between AD treatment, weight gain and MetS on a sample of MDD patients. Clinical findings have suggested that early weight gain due to AD treatment would increase the risk of both later weight gain and later MetS incidence. The relationship between AD use, response to treatment and weight gain remain complex. Despite the simultaneous increase in AD use and obesity trends in Western societies, additional prospective cohorts are needed to fully test the hypothesis that weight gain among AD users is indeed an iatrogenic effect. Although impact of AD on cardiovascular morbidity still cannot be ascertained, the results from the first chapter showed that AD use – irrespective of the class - does impact and worsen metabolic dysregulations, which would require specific clinical attention. A long term cohort study is required to confirm whether discontinuation and re-initiation of AD treatment would be linked to fluctuation in MetS dysregulations
Brand, Sarel Jacobus. "An investigation into the antidepressant–like profile of pioglitazone in a genetic rat model of depression / Brand S.J". Thesis, North-West University, 2011. http://hdl.handle.net/10394/7333.
Pełny tekst źródłaThesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2012.
Ruusa, Jaan. "On testosterone during alcohol withdrawal in men : effects on mood and insulin-like growth factor 1 /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-057-5/.
Pełny tekst źródłaWalker, Jillian L. "The Effects of Cultural Orientation Change on Metabolic Health in a Sample of Mexican Immigrants to the United States". BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4184.
Pełny tekst źródłaOsher, Susan. "One-carbon metabolism in adults with major depression". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0006/MQ46133.pdf.
Pełny tekst źródłaMitro, S. D., Susanna D. Mitro, Gloria T. Larrabure-Torrealva, Sixto E. Sanchez, Samantha A. Molsberry, Michelle A. Williams, Clary Clish i Bizu Gelaye. "Metabolomic markers of antepartum depression and suicidal ideation". Elsevier B.V, 2020. http://hdl.handle.net/10757/651846.
Pełny tekst źródłaRevisión por pares
Jones, Shirley A. "Tetrahydrobiopterin metabolism in depression and senile dementia of Alzheimer type". Thesis, Aston University, 1988. http://publications.aston.ac.uk/12519/.
Pełny tekst źródłaBaro, Cecilio C. "A Volumetric-Metabolic Study of Hippocampal Alteration in Female Major Depressive Disorder Patients". Thesis, KTH, Tillämpad fysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-175862.
Pełny tekst źródłaGracia, Rubio Irene 1986. "Neurobiological links between depression and drug dependence". Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/382484.
Pełny tekst źródłaLas experiencias tempranas tienen un papel importante en el desarrollo cerebral y las respuestas emocionales. La separación maternal supone un factor de riesgo de desarrollar enfermedades psiquiátricas, mientras que el modelo de nido en comuna se ha propuesto como una condición protectora. Además, el estrés crónico durante la infancia aumenta la vulnerabilidad a desarrollar trastornos por uso de sustancias, principalmente durante la adolescencia. Por ello, los estados depresivos están asociados con una mayor vulnerabilidad para el uso de drogas puesto que los pacientes depresivos podrían consumir drogas para aliviar sus síntomas. Nuestros resultados demuestran que las experiencias adversas durante la infancia reproducen la mayoría de las alteraciones comportamentales y neuroquímicas relacionadas con depresión en el ratón. Además, la separación maternal puede considerarse como un modelo conveniente para el estudio de la comorbilidad psiquiátrica entre depresión y el trastorno por uso de drogas, ya que reproduce alteraciones emocionales y motivacionales en el animal de experimentación, así como en el sistema dopaminérgico. Sin embargo, no podemos confirmar el papel protector del nido en comuna debido a las alteraciones comportamentales que hemos encontrado en nuestros estudios, probablemente debido a que dicho modelo origina costes energéticos y aumenta la competencia por la comida entre las crías.
Fang, Yiyu. "Conjugated linoleic acid : analysis, tissue distrubution, metabolism, and its effects on immune-induced growth depression in rats /". The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487949836207324.
Pełny tekst źródłaMartins, Ricardo Alves. "Termorregulação e depressão metabólica em endotermos". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/3/3139/tde-13102009-154825/.
Pełny tekst źródłaMetabolic depression of mammals and birds, animals of high metabolic demands, normally emerges as a response to food shortage and low ambient temperature. The main goal of this research is to explore, in a theoretical perspective, how the thermoregulatory system could extend the energy reserves of these endotherms decreasing metabolic costs under those environmental conditions. To approach the problem, we propose the use of control engineering theories to analyze the way the this minimization could occur, in other words, how the nervous system would act establishing a control (hypothalamic set-point) to minimize those costs during the thermoregulatory process. In this context, we propose a basic thermoregulation model that takes into account body temperature, metabolic rate and environmental temperature, and in which the set-point acts as a control. We show how this model can significantly reduce disturbances generated by ambient temperature. Using optimal control theory, we show how the hypothalamic set-point can emerge as a result of a minimization process of a functional related to thermoregulation costs. Also, how ambient temperature can define different metabolic profiles is explored, in terms of metabolic depression and the necessary return to euthermic conditions. To quantify this analysis we propose an index, based on the ratio between a constant metabolic cost and the metabolic cost defined by the controller. After a period in metabolic depression individuals should return to their euthermic condition, and, in situations of low environmental temperature, it is shown that the cost to return can be larger than the advantages. In this way, analyzing body mass influences we observed increased metabolic depression cost in larger individuals. This cost is even higher under lower environmental temperature. Finally, the cost related to the time elapsed, until the euthermic state is reached again, is considered. These last results are in accordance with current conception about the flexibility in hibernation process.
Sherman, Shermel B. "The Role of Neuropeptide Spexin in the Modulation of Metabolism and Behaviors". University of Toledo Health Science Campus / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=mco1596840064046446.
Pełny tekst źródłaVillarinho, Jardel Gomes. "POTENCIAL ANTIDEPRESSIVO E ANALGÉSICO DO 2-(3,4-DIMETOXI-FENIL)-4,5-DIIDRO-1H-IMIDAZOL (2-DMPI) EM CAMUNDONGOS". Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/3835.
Pełny tekst źródłaDepression and chronic pain coexist in several patients and may be modulated by the same neurotransmitter systems. In this context, various studies have demonstrated that antidepressants from the class of the inhibitors of monoamine oxidase-A (MAO-A) enzyme presented antinociceptive effect in different pain models in experimental animals, as well as analgesic action in clinic studies. Thus, in the present study were evaluated the MAO-A inhibitory properties, as well as the antidepressant and antinociceptive potential of the novel imidazoline compound 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice. 2-DMPI showed to be a mixed, reversible and preferential MAO-A inhibitor. The treatment with 2-DMPI (100-1000 μmol/kg, s.c.) produced an antidepressant-like effect in the tail suspension test without affecting motor activity of the animals. The mice treated with 2-DMPI showed a decrease in serotonin and dopamine turnover in specific brain regions, suggesting that the antidepressant-like effect of this compound was mediated by serotonergic and dopaminergic systems. This was confirmed by experiments showing that the antidepressant-like effect of 2-DMPI was abolished by pretreatment with serotonergic and dopaminergic receptor antagonists. In order to evaluate a possible antinociceptive action of 2-DMPI, a mice model of neuropathic pain, induced by chronic constriction injury (CCI) of the sciatic nerve was used. It was observed that mice submitted to CCI presented an increase in MAO-A activity in lumbar spinal cord compared with sham-submitted mice and that the treatment with 2-DMPI (30-300 μmol/kg, s.c.) reversed the CCI-induced mechanical hyperalgesia. Furthermore, the antihyperalgesic effect of 2-DMPI was reversed by intrathecal injection of the serotonergic 5-HT3 receptor antagonist ondansetron (10 μg/site). These results suggest that 2-DMPI, due to its ability to modulate MAO-A activity and, consequently, the monoaminergic systems, could be a promising prototype to the development of new drugs with antidepressant and analgesic properties.
A depressão e a dor coexistem em muitos pacientes e podem ser moduladas pelos mesmos sistemas de neurotransmissores. Nesse contexto, diversos estudos têm demonstrado que antidepressivos da classe dos inibidores da enzima monoamina oxidase-A (MAO-A) apresentam efeito antinociceptivo em diferentes modelos de dor em animais experimentais, assim como ação analgésica em estudos clínicos. Em vista disso, no presente estudo foram avaliadas as propriedades inibitórias sobre a atividade da MAO-A, assim como os potenciais antidepressivo e antinociceptivo do novo composto imidazolínico 2-(3,4-dimetoxi-fenil)-4,5-diidro-1H-imidazol (2-DMPI) em camundongos. Foi observado que o 2-DMPI é um inibidor misto, reversível e preferencial da MAO-A. O tratamento com 2-DMPI (100-1000 μmol/kg, s.c.) produziu um efeito tipo-antidepressivo no teste de suspensão da cauda, sem afetar a atividade motora dos animais. Os camundongos tratados com 2-DMPI (300 μmol/kg, s.c.) apresentaram uma diminuição na taxa de renovação da serotonina e da dopamina em regiões cerebrais específicas, sugerindo que o efeito tipo-antidepressivo desse composto foi mediado pelos sistemas serotoninérgico e dopaminérgico. Isto foi confirmado por experimentos que mostraram que o efeito tipo-antidepressivo do 2-DMPI foi abolido pelo pré-tratamento com antagonistas de receptores serotoninérgicos e dopaminérgicos. A fim de avaliar um possível efeito antinociceptivo do 2-DMPI, foi utilizado um modelo de dor neuropática, induzida pela injúria por constrição crônica (CCI) do nervo ciático, em camundongos. Observou-se que os camundongos submetidos à CCI apresentaram um aumento na atividade da MAO-A na medula espinhal lombar comparado com os animais falso-operados e que o tratamento com 2-DMPI (30-300 μmol/kg, s.c.) reverteu a hiperalgesia mecânica induzida pela CCI. Além disso, o efeito antinociceptivo do 2-DMPI foi revertido pela administração intratecal do antagonista do receptor serotoninérgico 5-HT3, ondansetrona (10 μg/sítio). Esses resultados sugerem que o 2-DMPI, devido à sua capacidade de modular a atividade da MAO-A e, consequentemente, os sistemas monoaminérgicos, parece ser um protótipo promissor para o desenvolvimento de novos fármacos com propriedades antidepressiva e analgésica.
Paslakis, Georgios, Arlette F. Buchmann, Sabine Westphal, Tobias Banaschewski, Erika Hohm, Ulrich S. Zimmermann, Manfred Laucht i Michael Deuschle. "Intrauterine Exposure to Cigarette Smoke Is Associated with Increased Ghrelin Concentrations in Adulthood". Karger, 2014. https://tud.qucosa.de/id/qucosa%3A70575.
Pełny tekst źródłaReinfried, Lutz. "Protonen-Magnet-Resonanz-Spektroskopie (1 H-MRS) mit 3,0 Tesla zur Erfassung cerebraler Metabolite im Frontalhirn depressiver Patienten unter Plazebo-kontrollierter Inositolgabe im Vergleich zu gesunden Probanden". Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15478.
Pełny tekst źródłaObjectives: By means of proton magnetic resonance spectroscopy (1H-MRS) with absolute quantification we wanted to confirm our previous finding of decreased ratios of the metabolites myo-Inositol/total creatine (mI/tCr) in the right frontal brain of depressives. Moreover, we tested the antidepressive effect of oral Inositol ingestion as add-on-therapy. We measured concentrations (mmol/kg ww) of mI, tCr (= Creatine + Phosphocreatine), Choline (Cho) and N-Acetyl-Aspartate (NAA) in the frontal brain. Methods: Single voxels (2x2x2 cm3) in the white matter of the left and right prefrontal region were examined in a three Tesla Bruker Medspec System (STEAM sequence, TR/TE/TM = 6000/20/30 ms). Metabolites were quantified using the LCModel. At baseline, 24 drug-free patients with unipolar depressive episodes were compared to 24 age and sex matched healthy controls. In a double blind, placebo controlled parallel-group design patients received daily 18 grams Inositol or placebo as an add on therapy to Citalopram over four weeks. Results: At baseline, mI, Cho and NAA concentrations showed no significant differences between patients and controls. The treatment with Inositol did not result in any significant differences to the treatment with placebo. Surprisingly the patients showed significant higher tCr concentrations in the left (5.57 ± 0.96 vs. 4.87 ± 0.63; + 15 %, p < 0.01) as well as in the right prefrontal region (5.29 ± 0.92 vs. 4.46 ± 0.41; + 17 %, p < 0.01) compared to controls. The treatment caused a trend towards a decrease of tCr in the left (day 28: 5.05 ± 1.16; – 12 %, p = 0.08) and in the right frontal hemisphere (day 28: 4.61 ± 1.07; – 9 %, p = 0.09) compared to baseline. The differences between the patients’ tCr at day 28 and the tCr of controls were no more significant. Conclusion: We have found a state dependent increase of tCr concentration indicating bifrontal deviations in Creatine transport or ATP synthesis in drug free unipolar depressives.
Reveneau, Carine. "Dietary source and availibility [i.e. availability] of fatty acids to manipulate ruminal protozoa, metabolism of fat, and milk fatty acid profile in lactating dairy cows". The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1204659455.
Pełny tekst źródłaGama, Marco Antônio Sundfeld da. "Desempenho, composição do leite e mecanismos envolvidos na depressão da gordura do leite (DGL) de vacas recebendo ácido linoléicos conjugados (CLA) e óleo de peixe na dieta". Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-17112004-164012/.
Pełny tekst źródłaDiet manipulation is an effective and rapid way to change milk composition, mainly for fat content. However, mechanisms are not fully undestood in despite of progress in the area over the last decade. Nowadays, it is known that a molecule of fatty acid (CLA trans-10 cis-12) which is formed in the rumen under specific feeding situations is capable of inhibiting milk fat synthesis. However, milk fat depression (MFD) has been observed even at conditions where there is no formation of trans-10 cis12 CLA (e.g. fish oil-supplemented diets). Although CLA effects on milk fat synthesis are well-established, previous study from our group also showed an increase on milk protein content in cows fed CLA. Two trials were conducted with two main objectives: 1) to determine if an additional supply of diet protein affects milk fat synthesis in cows fed CLA and 2) to study the mechanisms involved in MFD of cows fed diets with fish oil (FO) and different fiber levels. In the first trial, 48 lactating cows received the treatments as follow: 1) Control Diet (CD) + Lac100, 2) CD + CLA, 3) High Protein Diet (HPD) + Lac100 and 4) HPD + CLA. The Lac100 (calcium salts of soybean oil) was used as a placebo. CLA was protected by encapsulation (prills) and the product contained 16% CLA. In the second trial, 12 lactating dairy cows were evaluated in three periods: a) Basal: for 12 days, all cows received a baseline diet (High fiber without FO); b) Suplementation: 4 cows/group received the treatments for 21 days: 1) High fiber diet + FO (HF+FO); 2) Low fiber diet without FO (LF) and 3) Low fiber diet + FO (LF+FO); c) Post-supplementation: cows returned to baseline diet on 12 days. Results from the first trial showed that CLA protection method was innefficient. Thus, milk fat reduction was smaller than in other studies. Protection of calcium salts of soybean oil was also small which resulted in higher cis-9 trans-11 CLA and lower linoleic acid concentrations (P<0.05) in milk from cows fed Lac100. In despite of similar milk trans-10 cis-12 CLA increase in response to CLA and Lac100, milk fat content was lower (P<0.05) in cows fed CLA. It suggests the presence of other fat inhibitors (or precursors) in the product containing CLA isomers. Moreover, concentration of milk trans-10 cis-12 CLA explained ~50% of MFD suggesting others factors influencing milk fat synthesis. Results of the second trial were inedit in showing the close association of milk trans-9 cis-11 CLA and C18:1cis-11 concentrations and FO-induced MFD. MFD resulted from a lower (P<0,01) secretion of both de novo and preformed milk fatty acids. It suggests that mechanisms of FO-induced MFD must involve the inhibition of different lipogenic enzymes. The lower (P<0.01) dessaturase activity index in cows fed FO is consistent with this hypothesis. In contrast to FO, milk fat secretion was unchanged (P>0.1) by LF diet which is consistent with low CLA trans-10 cis-12 and C18:1trans-10 concentrations in milk from cows fed this diet. Contents of milk protein and milk lactose increased (P<0.05) in cows fed LF and FO diets, respectivelly.
McGregor, Neil Roland. "An investigation of the association between toxin producing staphylococcus, biochemical changes and jaw muscle pain". University of Sydney. Prosthetic Dentistry, 2000. http://hdl.handle.net/2123/369.
Pełny tekst źródłaHinnouho, Guy-Marino. "Phénotype « obésité à profil cardiométabolique normal » et risque de pathologies chroniques dans les cohortes Whitehall II et GAZEL". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T060/document.
Pełny tekst źródłaObesity has become a major public health concern. It is frequently associated with several cardiometabolic abnormalities such as hypertension, insulin resistance and dyslipidemia leading to type 2 diabetes and cardiovascular disease. However, the frequency of these abnormalities varies widely among obese subjects, making this chronic condition a very heterogeneous clinical situation. As such a new concept has emerged, involving a population of patients without metabolic risk, called "metabolically healthy obese" (MHO). Intense interest surrounds the MHO phenotype with on-going efforts to understand the mechanisms underlying this phenotype and its long-term consequences. The main objective of this thesis was to study the relationship between the MHO phenotype and various chronic diseases known to be associated with obesity. Data from the Whitehall II and GAZEL cohorts were used to examine associations between this phenotype and mortality, cardiovascular diseases, type 2 diabetes, and depression. Compared to metabolically healthy normal weight subjects, MHO individuals have an increased risk of overall and cardiovascular mortality, type 2 diabetes and cardiovascular diseases, but not depression. Compared to metabolically unhealthy obese subjects, MHO individuals have a similar risk of mortality and cardiovascular disease, but a lower risk of type 2 diabetes, and depression. Our results suggest that obesity with normal cardiometabolic profile is not a benign condition. A better understanding of this phenotype will enhance therapeutic decision making and possibly help to identify new therapeutic targets
Tran, Hoang V. "Ventricular Arrhythmias Complicating Coronary Artery Disease: Recent Trends, Risk Associated with Serum Glucose Levels, and Psychological Impact". eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/980.
Pełny tekst źródłaHenninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1". eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.
Pełny tekst źródłaYang, Ju-Ya, i 楊茹雅. "Impact of Depression Tendency and Health-Promoting Lifestyle on Metabolic Syndrome". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/43673558856751684014.
Pełny tekst źródła亞洲大學
健康產業管理學系健康管理組碩士在職專班
103
Research background: Chronic diseases have become ten major causes of death in past years, and metabolic syndromes are the early stage of chronic diseases, including various predecessor states and risk factors in cardiovascular diseases and error of metabolism. Past research findings presented that patients with metabolic syndromes, which were closely related to other diseases like malignant tumors and depression, showed 4-6 times chances suffering from hypertension and diabetes mellitus. This study therefore aims to understand the distribution the metabolic syndromes, depression tendency, and health promotion lifestyle of military personnel, further discusses the correlation between depression tendency, health promotion lifestyle and metabolic syndromes, and finds out the factors. Research method: With cross-sectional research, military personnel with physical examinations in a regional hospital in March, 2015, are investigated. The questionnaire covers the contents of personal characteristics, medical data, Center for Epidemiological Studies Depression Scale (CES-D), and Health Promotion Lifestyle Scale II (HPLP-II). Total 393 valid copies are collected; Descriptive Statistics, Chi-square Analysis, and Independent Sample t-test are used for statistical analyses; and, Logistic Regression Analysis is applied to discuss the factors in the metabolic syndromes of military personnel. Research result: Most participants are males, total 329 (83.7%), with the average age 27.7. The mean score for depression appears 12.73 (full score 60), and total 132 participants (33.6%) present depression tendency (score ³16). The mean score for health promotion lifestyle reveals 128.85 (full score 208), in which the dimension of interpersonal support receives the highest score. 11.5% (45) cases appear metabolic syndromes; 55.7% military personnel show at least one aberrant metabolic syndrome index, while 25.7% of them reveal more than two aberrant indices; and, among aberrant metabolic syndrome indices, higher blood pressure (29%), abdominal obesity (20.4%), and lower high-density cholesterol (18.6%) are top three indices. According to Logistic Regression Model, the risk of suffering from metabolic syndromes increase 1.12 times with one year increase of age; the ones with family medical histories reveal 2.71 times higher risk of suffering than those without family medical histories; the suffering risk would enhance 1.42 times when BMI increases 1kg/m2; and, the risk of suffering would reduce 0.04 time when the total score of health promotion lifestyle increases 1. Conclusion and suggestion: Significant factors in the metabolic syndromes of military personnel contain age, family medical history, BMI, and health promotion lifestyle. The following suggestions therefore are proposed in this study. (1) Patients suffering from metabolic syndromes and the ones with BMI exceeding the normal value could be reinforced the health promotion lifestyle cognition, continuously intervened with nutrition education and exercise courses, and proceeded health weight management to enhance the opportunity to reverse metabolic syndromes. (2) Participants with depression tendency should be actively offered mental health related health education and counseling, and personnel with depression symptoms should be actively assisted and intervened.
MacIntyre, Scott. "The Effects of Metabolic Depression Induced by Food Deprivation on Hypoxia Tolerance of Juvenile Rainbow Trout (Oncorhynchus mykiss)". Thesis, 2011. http://hdl.handle.net/1974/6838.
Pełny tekst źródłaThesis (Master, Biology) -- Queen's University, 2011-10-12 23:21:04.517
Austin-Ketch, Tammy. "Buffalo Cardio-Metabolic Occupational Police Stress study an exploratory analysis of post-traumatic stress, depression, metabolic syndrome and salivary cortisol /". 2008. http://proquest.umi.com/pqdweb?did=1594501291&sid=1&Fmt=2&clientId=39334&RQT=309&VName=PQD.
Pełny tekst źródłaTitle from PDF title page (viewed on Feb. 11, 2009) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Violanti, John Includes bibliographical references.
Park, Eunmi. "Molecular and biochemical responses to sand-dwelling in the three-spot wrasse (Halichoeres trimaculatus)". Thesis, 2008. http://hdl.handle.net/10012/4103.
Pełny tekst źródłaKuo, Shu-Yu, i 郭淑瑜. "Relations of Depression to Metabolic Risk Profile and Hormones in non-Clinical Samples". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/73803467947534189869.
Pełny tekst źródła國立臺灣大學
流行病學研究所
95
Depression and obesity are both increasingly prevalent in different developmental stages. The nature of the relationships between depression and obesity, and other metabolic variables, however, remains inconclusive. The etiology underlying the depression-obesity link is also largely not clear. In this dissertation, three studies were carried out in order to investigate the nature of the association between depression and metabolic function in adolescents, and older adults, respectively; and to examine the underlying determinants of the association. A special focus will be made on the hormonal factors, such as cortisol and leptin, to examine their role in the association. Such a combination of detailed psychological assessments and physiological measurement is expected to help shed light on the interrelation of psychological well-being and metabolic function. Study 1: Genetic Correlation between Anxious/Depression and Metabolic Risk Factors in Adolescents: A Multivariate Twin/Sibling Analysis Background: To examine whether anxious/depression was associated with metabolic risk factors in non-referred adolescents and determine the relative influence of genetic and environmental factors underlying the association. The role of cortisol on the association was also investigated. Method: In a sample of same-sex twins (n = 183 pairs) and sib-pairs (n = 30 pairs) aged 12-18 recruited from middle schools in Taipei, anxious/depression was assessed using the Child Behavior Checklist. Metabolic phenotypes including body mass index (BMI), levels of glucose, insulin, high-density lipoprotein cholesterol (HDL-C), and blood pressure as well as cortisol levels were measured. Desired BMI was also examined. Multivariate genetic analyses were conducted using structural equation modeling. Results: The majority of participants fell within the category of normal weight (55%) or underweight (38%), of which 84% and 37%, respectively, wished to lose weight as revealed by the disparity between actual and desired weight. Higher scores in anxious/depression were associated with lower levels in BMI, desired BMI, and systolic blood pressure as well as with higher levels in HDL-C and, with a borderline significance level, mid-morning cortisol. There were genetic correlations between anxious/depression and BMI (rG = -0.14), desired BMI (rG = -0.18), systolic blood pressure (rG = -0.15), and the metabolic factor (rG = -0.19) derived from factor analysis. Conclusions: There was a small but significant genetic association between anxious/depression and certain metabolic risk factors, which was unlikely explained by cortisol levels, in adolescents mainly of normal- or under-weight. These provide new insights regarding the etiology of both anxious/depression and metabolic profiles. Study 2: Genetic Correlations Between Leptin and Insulin Resistance Independent of Body Mass Index in Adolescents: A Multivariate Twin/Sibling Analysis Background: Leptin levels are frequently correlated with insulin levels, blood pressure, even after adjustment for body mass index (BMI). Nonetheless, the extent to which genes or environmental factors contribute to the covariation among these traits has not been fully understood. We aimed to determine the relative influence of genetic and environmental factors underlying the associations between leptin and metabolic traits. Methods: A cross-sectional twin study was performed in 2002. Participants were recruited from middle schools in Taipei. A sample of monozygotic twins (n = 130 pairs), dizygotic twins (n= 68 pairs), and sib-pairs (n = 30 pairs) aged 12-18 was studied. Serum leptin levels and metabolic phenotypes including BMI, levels of fasting insulin, fasting glucose, and blood pressure were measured. Insulin resistance was determined by homeostasis model assessment (HOMA-IR). Multivariate genetic analyses were conducted using structural equation modeling. Results: Leptin, BMI, insulin, HOMA-IR, and systolic blood pressure tended to be genetically correlated with each other, with genetic correlation ranging from 0.25 to 0.66. After adjusting for BMI, the positive genetic correlations of leptin with insulin levels and HOMA-IR were attenuated but remained significant, while those of leptin, insulin, and HOMA-IR with systolic blood pressure disappeared. Multivariate modeling identified a common genetic factor influenced leptin, insulin, and HOMA-IR. Conclusions: Substantial genetic correlations between leptin and insulin as well as between leptin and insulin resistance were found. These results provide empirical evidence to include both leptin and insulin for future multivariate genetic analyses of metabolic function. Study 3: Depression trajectories and obesity in a longitudinal study of elderly in Taiwan Background: Depression and obesity are common in older adults. However, the course of depression changes over time and their relationship with obesity are not clear. We aimed to 1) characterize trajectories of depressive symptoms and identify predictors of trajectory classes; 2).determine the association between these trajectories and obesity as well as subsequent metabolic function and cortisol levels. Method: A prospective cohort study of older Taiwanese adults (n = 3922) was carried out between 1989 and 1999. Depression was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). Metabolic variables including body mass index (BMI), lipid profile, levels of glucose, and blood pressure as well as cortisol levels were measured. Trajectory analyses were conducted using semi-parametric group-based modeling. The associations between depression trajectories and baseline characteristics, and BMI categories were examined using multinomial logistic regression. Results: Four distinctive trajectories of depressive symptom were identified: class 1 (“persistent low”; 41.8 %), class 2 (“persistent mild”; 46.8 %), class 3 (“late peak”; 4.2 %), and class 4 (“high-chronic”; 7.2 %). Gender, educational level, regular exercise, chronic disease, and self-assessed health predicted development of trajectory pattern. The pattern of depression trajectory was inversely associated with BMI. Women with BMI≧25.0 were less likely to be in class 2, 3, and 4 (OR = 0.61, 0.48, 0.19 respectively). The odds for men with BMI <18.5 to develop class 3 and 4 were 3.24, and 4.14, respectively. High depressive symptoms were positively linked to subsequent high blood pressure and high levels of cortisol. Conclusions: There existed distinct classes of depressive symptoms changes over time. An inverse association for depression and BMI, while a positive association for depression and high blood pressure was found. These findings may be of interest to health professionals who wish to target depression and obesity to promote the well-being in late life.
Kuo, Shu-Yu. "Relations of Depression to Metabolic Risk Profile and Hormones in non-Clinical Samples". 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2007200716302800.
Pełny tekst źródłaLIN, CHIA-CHUN, i 林佳君. "Relationships Among Disease Knowledge, Depression, Quality of Life and TCM Syndromes in Patients with Metabolic Syndrome". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ga5vu3.
Pełny tekst źródła國立臺北護理健康大學
中西醫結合護理研究所
106
The purpose of this study is to investigate the effect of demographic data, disease characteristics, and traditional Chinese medicine (TCM) syndrome type of patients with metabolic syndrome on their disease knowledge, depression, and quality of life. This cross-sectional correlational study used purposive sampling to enroll a total of 161 patients at the outpatient clinic of metabolism in a certain regional teaching hospital in the northern Taiwan as the subjects. The questionnaire collected the data of patients, such as basic demographic data, disease characteristics, metabolic syndrome disease knowledge, depression, quality of life, and TCM syndrome type. This study used statistical methods, such as frequency distribution, percentage, mean, standard deviation, regression equation, and Pearson product-moment correlation to perform analyses. The research results showed that: (1) Results of descriptive statistics: a total of 161 patients were enrolled, with 81 male and 80 female patients. The mean age was 62.66 years old, the mean weight was 78.02 kg, and the mean waist circumference was 99.22 cm. The TCD syndrome type of most of the patients was weak constitution type (38.5%), and the score of disease knowledge was lower (3.34 points; total score 12 points). No patients experienced depression tendency (93.8%). The patients’ quality of life was moderate and above (90.08 points) (total score 140 points). (2) Results of differential analysis: educational background, marital status, employment status, and a history of hypertension, diabetes, and low density lipoprotein (LDL) and high density lipoprotein (HDL) all had a significant effect on disease knowledge (p<0.05); employment status, exercise, and high uric acid all had a significant effect on depression (p<0.05); marital status, exercise, and high uric acid all had a significant effect on quality of life(p<0.05); demographic data, disease characteristics, depression, and quality of life had a significant effect on different TCD syndrome types (p<0.05) (except for yin deficiency constitution). (3) Results of correlational analysis: weight (r=0.16, p<0.05) and total cholesterol (r=0.19, p<0.05) were positively correlated with disease knowledge. Age (r=-0.41, p<0.01) was negatively correlated with disease knowledge. For the results of depression scale (WHO-5), the higher the score is, the higher the well-being is. The depression score (r=0.68, p<0.01) was positively correlated with quality of life. (4) Results of test on mediators: the mediating effect of disease knowledge did not reach statistical significance (z=-0.15, p>0.05), namely, the depression and quality of life of patients with metabolic syndrome could not be further improved through disease knowledge. The depression of patients with metabolic syndrome was correlated with their quality of life. Depression affected physiology and even quality of life. Future care for patients with metabolic syndrome should better understand depression to further prevent patients from developing depression symptoms, as well as to improve their quality of life and provide complete physical, psychological, and spiritual care. Moreover, hopefully, the identification of TCM syndrome type, the understanding of correlation between disease and TCM syndrome type, and the provision of care integrating western medicine with TCM, can reduce depression complication of metabolic syndrome and offer good quality of life.
Liang-Jen i 陳亮仁. "Associations Among Metabolic Syndrome , Depression, Excessive Sleepiness, and Health-related Quality of Life:Gender Difference in The Mid-aged and Elderly". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89020210347420436558.
Pełny tekst źródła中山醫學大學
醫學研究所
99
Objective: The aim of this study is to exam the associations among metabolic syndrome, depression, excessive sleepiness, and health-related quality of life (HRQoL).We hypothesized that metabolic syndrome would be associated with lower HRQoL score and higher depression and excessive sleepiness score. Methods and Materials: 378 eligible mid-aged and elderly participant were recruited to our study when their adult health examination, provided by Taiwanese National Health Insurance Company, were completed. We also offer additional and free HDL measurement to meet the criteria of metabolic syndrome. The Medical Outcome Study, short form-36 (SF-36) Beck Depression Inventory 2nd edition (BDI II) and the Epworth sleepiness scale(ESS)wese used to assess HRQoL, the level of depression, and the level of sleepiness, respectively. Differences in HRQoL and in clinical and psychological characteristics were compared among participants with and without metabolic syndrome. Multiple variances regression was used to determine the predictors of HRQoL, depression, and excessive sleepiness. Results: Metabolic syndrome was associated with lower scores on the subscales of SF-36 and on the physical component summary (PCS) score only in female. Depression and age are the top two significant predictors of lower score of SF-36 by multiple variance regression analysis. For ESS score, depression and diabete mellitus (DM) history were two predictors in female, whereas BMI and age in male. After adjusting other potential confounding variances, the presence of metabolic syndrome has little effect on depression and sleepiness score . Conclusion and Suggestion: The results indicate that metabolic syndrome is associated with poor HRQoL solely in women, which might be accounted mainly for by physical instead of mental health. That gender difference on predictors of ESS score might imply heterogeneous effect on ESS score between difference gender.
Hsin, Chen Chuan, i 陳全信. "Exploring the Relationships between Metabolic Syndrome, Depression and Sleep Quality within Hospital Administrative Staffs in a Regional Hospital in Southern Taiwan". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/44136744584135430021.
Pełny tekst źródła美和科技大學
健康照護研究所
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Hospital administration integrates front-line work and rear service. The operational quality and efficiency are critical for successful hospital administration and rear service. Thus we investigate the conditions about metabolic syndrome, depression and sleep quality of hospital administrative employees. The results can be used as references of hospital administrative employee health policy, thereby improving the health of hospital administrative employees, and creating a win-win situation with staffs and organization. Our study aimed to investigate the prevalence and relevance of hospital administrative employees’ metabolic syndrome, depression and sleep quality. This is a cross-sectional quantitative study with purposeful sampling. We used Taiwanese Depression Inventory, Pittsburgh Sleep Quality Scale and structured questionnaire designed by ourselves to collect the health examination data of hospital administrative employees for analysis. We also designed instructions of questionnaire fill-out and provided them together with the questionnaires. Health examination data collection: We collected the health examination data of hospital administrative employees with 2010 annual health examination of hospital employees (from September 2010 to December 2010). Questionnaire collection period: From January 1, 2011 to February 28, 2011. The total number of participants is 224. After excluding eight people did not complete the questionnaires, there are 216 valid samples. We used SPSS 17.0 for Windows for data processing and analysis. The results are as follows: I. There was 27 metabolic syndrome patients. The prevalence was 12.1%. They were 12 males (male prevalence 13.8%) and 15 females (female prevalence 10.9%). II. In the finding of depression index, there were 183 (84.7%) without depressed mood and 33 (15.3%) with depressed mood. Non-front line staffs had higher rate of depressed mood than front line staffs; and military staffs had higher rate of depressed mood than non-military staffs. III. There are 81(37.5%) with poor sleep quality and 135(62.5%) with good sleep quality. Non-front line staffs had worse sleep quality than front line staffs; those who worked more than 3 years had worse sleep quality than those who worked less than 3 years; and those who are diseased had worse sleep quality than those who are not diseased. IV. We used multiplelogistic regression for further analysis to identify variables influencing sleep quality. The results showed that the risk of poor sleep quality of those with a disease history are 4.40 times (95% CI=1.57-12.29)of those without disease history; and of those with depressed mood are 13.14 times (95% CI=4.37-39.43)of those without depressed mood. Both results are statistically significant. The results can be used to establish a mechanism for caring the psychological state and lifestyle after work of employees, and improving their physical and spiritual quality as well as efficiency, thus increasing the competitiveness of the hospital operations.