Artykuły w czasopismach: „Meta3C”

1

Singh, R. J., i T. Tsuchiya. "Cytogenetics of an unstable trisomie in barley (Hordeum vulgare)". Genome 36, nr 2 (1.04.1993): 350–55. http://dx.doi.org/10.1139/g93-048.

Pełny tekst źródła

Streszczenie:

The origin, identification, meiotic chromosome behavior, and breeding behavior of an unstable trisomic barley were studied. The extra chromosome originated by breakage and fusion of an acrocentric chromosome 3 in a plant from an F2 population of a cross between acrotrisomic 3L3S (2n = 14 + 1 acro3L3S) and a balanced lethal stock, xc. (xantha) ac (albino). The F2 population segregated only for the albino trait. The genotypic constitution of the trisomic plant was ac ac (for both normal chromosome 3) and Ac (for the unstable metacentric chromosome). The unstable extra metacentric chromosome was designated as metacentric 3B (abbreviated as meta3B). Meiotic chromosome behavior in plants with 2n = 14 + 1 meta3B differed from plant to plant and within spikes. Some plants showed only trisomic cells with a chromosome configuration of 1 III + 6 II and 7 II + 1 I at metaphase I, whereas other plants showed both trisomie and disomic cells (7 II) that resulted from the elimination of the extra meta3B. The frequency of ring trivalents was low (6.8%). An average transmission rate of unstable meta3B ranged from 4.3 to 12.9%. The elimination of meta3B, and hence loss of the dominant Ac allele, resulted in albino seedlings as well as white stripes on plants, leaves, and spikes. Chromosome numbers of albino seedlings in the progeny of 2n = 14 + 1 meta3B were all diploid (2n = 14), while green seedlings contained 2n = 14 + 1 meta3B. However, progenies of some spikes of one trisomic plant showed a low frequency of green diploids and metatrisomics (2n = 14 + 1 meta3B), which was attributed to crossing-over.Key words: aneuploid, chromosome elimination, kinetochore, meta3B.

Style APA, Harvard, Vancouver, ISO itp.

2

Moore, Courtney, Weijue Gao i Pedram Fatehi. "Cationic Lignin Polymers as Flocculant for Municipal Wastewater". Polymers 13, nr 22 (9.11.2021): 3871. http://dx.doi.org/10.3390/polym13223871.

Pełny tekst źródła

Streszczenie:

The radical polymerization of acid-washed and unwashed softwood kraft lignin with [2-(methacryloyloxy) ethyl] trimethylammonium chloride (METAC) was attempted to investigate the production of lignin-based flocculants for simulated wastewater. The incorporation of METAC onto lignin resulted in a cationic charge density (2.3–3.3 meq/g), increased water solubility (89–96% in neutral pH), and increased molecular weight (70,000–210,000 g/mol) of lignin. The lignin–METAC polymers generated from acid-washed lignin had higher molecular weights than those generated from unwashed lignin. The lignin–METAC polymers showed lower resistance to thermal decomposition than unmodified lignin due to the inclusion of PolyMETAC. The unmodified acid-washed lignin samples did not significantly affect the COD of the wastewater, while the unmodified unwashed lignin samples contributed to the COD, implying that unmodified lignin was not suitable for wastewater treatment. The flocculation of wastewater with lignin–METAC led to the chemical oxygen demand (COD) reduction of 17–23% and total organic carbon (TOC) drop of 51–60%. The lignin–METAC polymer with the highest molecular weight (produced from acid-washed lignin) reached the highest COD removal, while lignin–METAC polymer with the highest charge density (produced from unwashed lignin) reached the highest TOC removal. Focused beam reflectance measurement (FBRM) studies revealed that the lignin–METAC polymer produced from acid-washed lignin with a high molecular weight generated larger and more flocs in wastewater than the lignin–METAC polymer produced from unwashed lignin. The comparison of theoretical and experimental dosages required for neutralizing the charges of wastewater demonstrated that charge neutralization was the main flocculation mechanism, although a bridging mechanism was also involved for component removals from wastewater. The use of 1 mg/L of alum along with 65 mg/L lignin–METAC in a dual coagulation–flocculation system led to higher average phosphorous (42%) and COD (44%) removals than the singular flocculation system only using 65 mg/L of lignin–METAC (with phosphorous removals of 3.4% and COD removals of 18.7%). However, lignin–METAC flocculant slightly increased the ammonia–nitrogen content in both singular flocculation and dual coagulation–flocculation systems due to the residual ammonia content of lignin–METAC. The coagulation–flocculation system determined that the use of lignin–METAC (65 mg/L) could reduce the alum dosage significantly while maintaining a similar organic content reduction of 44% for wastewater.

Style APA, Harvard, Vancouver, ISO itp.

3

Kohno, Tomoki, Haruaki Kitagawa, Ririko Tsuboi, Fan Deng, Hirohiko Sakai, Tingyi Wu, Yo-Shiuan Fan, Linghao Xiao i Satoshi Imazato. "Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters". Materials 17, nr 4 (15.02.2024): 896. http://dx.doi.org/10.3390/ma17040896.

Pełny tekst źródła

Streszczenie:

This study examined the antibacterial effects and physical properties of a novel resin composite incorporating poly[{2-(methacryloyloxy)ethyl}trimethylammonium chloride] (poly(METAC)), a methacrylate cationic polymer comprising quaternary ammonium compounds (QACs). Resin composites incorporating poly(METAC) were fabricated by adding 6 wt.% METAC aqueous solution to a commercially available resin composite. The FE-SEM/EDS and Raman spec-troscopy analyses showed that METAC was assembled and polymerized in the resin composites after curing. The antibacterial effect was evaluated by inoculating Streptococcus mutans or Strepto-coccus sobrinus suspensions on the surface of cured resin composites, and the experimental resin composites incorporating poly(METAC) clusters exhibited bactericidal effects even after 28 days of ageing. The physical properties of the experimental resin composites were within the ISO-stipulated ranges. Newly fabricated resin composites containing the QAC-based poly(METAC) cluster ex-hibited long-term bactericidal effects against oral bacteria on their surfaces and demonstrated ac-ceptable physical properties for clinical use.

Style APA, Harvard, Vancouver, ISO itp.

4

Shiga, Toshiki, Hiromitsu Mori, Keiichi Uemura, Ryota Moriuchi, Hideo Dohra, Aika Yamawaki-Ogata, Yuji Narita, Akihiro Saito i Yohei Kotsuchibashi. "Evaluation of the Bactericidal and Fungicidal Activities of Poly([2-(methacryloyloxy)ethyl]trimethyl Ammonium Chloride)(Poly (METAC))-Based Materials". Polymers 10, nr 9 (26.08.2018): 947. http://dx.doi.org/10.3390/polym10090947.

Pełny tekst źródła

Streszczenie:

Poly([2-(methacryloyloxy)ethyl]trimethyl ammonium chloride) (METAC) and the gels were prepared and evaluated for their bactericidal and fungicidal activities. The antimicrobial properties of poly(METAC) were tested against Escherichia coli (E. coli), Bacillus subtilis (B. subtilis), Saccharomyces cerevisiae (Sa. cerevisiae), methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa (P. aeruginosa), and Candida albicans (C. albicans). Moreover, the structural forms of the linear and cross-linked poly(METAC) were investigated for their influences on bacterial aggregation, precipitation, and cell-death. To our knowledge, this is the first report on the comparison of the antimicrobial properties of poly(METAC) and poly(METAC)-gels. The bactericidal and fungicidal activities were evaluated by determining minimum inhibitory concentrations (MICs), UV–Vis spectroscopy, and fluorescence and confocal microscopies. The MICs were found to be 123 (MSSA), 123 (MRSA), 123 (P. aeruginosa), 370 (E. coli), 123 (B. subtilis), 370 (C. albicans), and 370 μg/mL (Sa. cerevisiae), as determined by broth dilution, and 370 (MSSA), 370 (MRSA), 370 (P. aeruginosa), 3300 (E. coli), 370 (B. subtilis), 1100 (C. albicans), and >10,000 μg/mL (Sa. cerevisiae), as determined by paper disc diffusion (on solid medium). The poly(METAC)-gels achieved rapid adsorption/precipitation of bacteria via the cationic surface charge. Thus, these poly(METAC)-based polymers can potentially be used as antibacterial materials.

Style APA, Harvard, Vancouver, ISO itp.

5

Wang, Shoujuan, Fangong Kong, Pedram Fatehi i Qingxi Hou. "Cationic High Molecular Weight Lignin Polymer: A Flocculant for the Removal of Anionic Azo-Dyes from Simulated Wastewater". Molecules 23, nr 8 (11.08.2018): 2005. http://dx.doi.org/10.3390/molecules23082005.

Pełny tekst źródła

Streszczenie:

The presence of dyes in wastewater effluents made from the textile industry is a major environmental problem due to their complex structure and poor biodegradability. In this study, a cationic lignin polymer was synthesized via the free radical polymerization of lignin with [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (METAC) and used to remove anionic azo-dyes (reactive black 5, RB5, and reactive orange 16, RO16) from simulated wastewater. The effects of pH, salt, and concentration of dyes, as well as the charge density and molecular weight of lignin-METAC polymer on dye removal were examined. Results demonstrated that lignin-METAC was an effective flocculant for the removal of dye via charge neutralization and bridging mechanisms. The dye removal efficiency of lignin-METAC polymer was independent of pH. The dosage of the lignin polymer required for reaching the maximum removal had a linear relationship with the dye concentration. The presence of inorganic salts including NaCl, NaNO3, and Na2SO4 had a marginal effect on the dye removal. Under the optimized conditions, greater than 98% of RB5 and 94% of RO16 were removed at lignin-METAC concentrations of 120 mg/L and 105 mg/L in the dye solutions, respectively.

Style APA, Harvard, Vancouver, ISO itp.

6

Xiao, Shengwei, Yuyu Zhao, Shuqi Jin, Zhicai He, Gaigai Duan, Haining Gu, Hongshun Xu, Xingyu Cao, Chunxin Ma i Jun Wu. "Regenerable bacterial killing–releasing ultrathin smart hydrogel surfaces modified with zwitterionic polymer brushes". e-Polymers 22, nr 1 (1.01.2022): 719–32. http://dx.doi.org/10.1515/epoly-2022-0055.

Pełny tekst źródła

Streszczenie:

Abstract Building long-lasting antimicrobial and clean surfaces is one of the most effective strategies to inhibit bacterial infection, but obtaining an ideal smart surface with highly efficient, controllable, and regenerative properties still encounters many challenges. Herein, we fabricate an ultrathin brush–hydrogel hybrid coating (PSBMA-P(HEAA-co-METAC)) by integrating antifouling polyzwitterionic (PSBMA) brushes and antimicrobial polycationic (P(HEAA-co-METAC)) hydrogels. The smart bacterial killing–releasing properties can be achieved independently by the opposite volume and conformation changes between the swelling (shrinking) of P(HEAA-co-METAC) hydrogel layer and the shrinking (swelling) of PSBMA brushes. The friction test reveals that both METAC and SBMA components support great lubrication. By tuning the initial organosilane (BrTMOS:KH570) ratios, the prepared PSBMA-P(HEAA-co-METAC) coating exhibits different antibacterial abilities from single “capturing–killing” to versatile “capturing–killing–releasing.” Most importantly, 99% of the bacterial-releasing rate can be easily achieved via 0.5 M NaCl treatment. This smart surface not only possesses long-lasting antibacterial performance, only ∼1.09 × 105 cell·cm−2 bacterial residue even after 72 h exposure to bacteria solutions, but also can be regenerated and triggered between water and salt solution multiple times. This work provides a new way to fabricate antibacterial smart hydrogel coatings with bacterial “killing–releasing” functions and shows great potential for biomedical applications.

Style APA, Harvard, Vancouver, ISO itp.

7

Chang, Cheng, Qing-Fu Wang, Jun-Chao Guo, Duo-Duo Li, Yu-Bo Fan i Jian-Min Wen. "The Biomechanical Relationship between Hallux Valgus Deformity and Metatarsal Pain". Journal of Healthcare Engineering 2020 (26.03.2020): 1–7. http://dx.doi.org/10.1155/2020/8929153.

Pełny tekst źródła

Streszczenie:

Metatarsal pain is a common pathological outcome in patients with a hallux valgus (HV) deformity. However, the relationship between the degree of HV deformity and metatarsal pain has not been systematically examined. The purpose of the present study was to investigate the correlation between metatarsal pain and the degree of HV deformity. Between October 2017 and September 2018, 512 HV patients (944 feet) participated in an evaluation of their HV angle (HVA) using X-ray images. The participants were divided into four groups corresponding to their HVA (<15°, 15° to 20°, 21° to 40°, or >40°). Load rate, impulse, contact duration, and contact area were measured and recorded as dynamic gait parameters using the RsScan system. Data were evaluated using SPSS statistical software. The visual analog scale (VAS) was used to assess metatarsal pain. For the four HV deformity groups, the peak value of impulse and contact duration was concentrated on the second and third metatarsals (Meta2 and Meta3) (P<0.05); contact area was also shown on metatarsals 1, 2, and 5 (P<0.05). Metatarsal pain on Meta2 had the highest VAS score (VAS: 6.57), followed by Meta3 (Mean VAS: 5.72). In the HV > 40° group, the load location on Meta2 was transferred to Meta1. The percent of pain attributed to Meta2 and Meta3 was also increased in this group. These findings illustrated that metatarsal pain was primarily located on Meta2 and Meta3 in the different degrees of HV deformity. This information can provide the location to target for pain relief and help guide further rehabilitation.

Style APA, Harvard, Vancouver, ISO itp.

8

Andayani, Santi, i Ni Made Savitri Paramita. "REPRODUKSI WACANA METABO LAW DALAM PEMBENTUKAN STEREOTYPE FAT CHARACTER PADA ANIME JEPANG". IZUMI 7, nr 1 (19.04.2018): 11. http://dx.doi.org/10.14710/izumi.7.1.11-21.

Pełny tekst źródła

Streszczenie:

(Title: The Reproduction Of Metabo Law Discourse In Constructing Fat Characters Stereotype In Japanese Animes) Japanese government through Ministry of Health, Labor and Welfare (MHLW) in 2008 issued the Metabo Law regulation, which is the standard of medical and health guidance that is done specifically with the purpose to decrease the number of obesity which cause the metabolic syndrome. This regulation put the body of each individual to be open to the public. Using Foucault’s perception, this study look how Metabo Law works and how the reproduction of Metabo Law discourses constructing stereotype of fat character in Japanese anime. This study took data from 14 fat character in 13 anime, airing in 2008’s until 2015’s. To complete the data, interview were conducted on 5 Japanese about their understanding about Metabo Law. This study shows that with the normalization process using yearly general checkup and the reproduction of Metabo Law discourses, Japanese government successfully change the Japanese mindset and their behavior in maintained a healthy life style and to stay slim. The stereotype of the fat character that emerge as the product of reproduction of Metabo Law discourses is greedy, careless, cowardly, shy/ have low self-confident, and an otaku.

Style APA, Harvard, Vancouver, ISO itp.

9

Guan, Xiaolin, Donghai Zhang, Tianming Jia, Yang Zhang, Li Meng, Qijun Jin, Hengchang Ma, Dedai Lu, Shoujun Lai i Ziqiang Lei. "Intriguingly tuning the fluorescence of AIEgen using responsive polyelectrolyte microspheres". RSC Advances 6, nr 109 (2016): 107622–27. http://dx.doi.org/10.1039/c6ra23380e.

Pełny tekst źródła

Streszczenie:

We successfully synthesized counterion-sensitive TPE–METAC polyelectrolyte microspheres and tuned its fluorescence and size by ClO₄⁻, PF₆⁻ and TFSI⁻.

Style APA, Harvard, Vancouver, ISO itp.

10

Pei, Yi Wen, Jadranka Travas-Sejdic i David E. Williams. "Synthesis and Characterization of Polysulfobetaines and their Random Copolymers". Materials Science Forum 700 (wrzesień 2011): 219–22. http://dx.doi.org/10.4028/www.scientific.net/msf.700.219.

Pełny tekst źródła

Streszczenie:

[3-(Methacryloylamino) propyl) dimethyl (3-sulfopropyl) ammonium hydroxide] polymer, known as poly (MPDSAH), and the random copolymers based on methyl methacrylate (MMA), methacryloxyethyltrimethylammonium (METAC) and 3-sulfopropyl methacrylate potassium (SPMA) were synthesized via Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization technique. Solution properties of these (co) polymers in response to temperature and ionic strength have been studied using dynamic light scattering (DLS). For poly (MPDSAH), polymer size decreased from 500 nm to 10 nm (in diameter) when the polymer aqueous solution was heated up from 15°C to 60°C or added 20 mM sodium chloride. The solution behaviour of poly (METAC-stat-MMA-stat-SPMA) is opposite to that of poly (MPDSAH): the size of polymer increased from 10 nm to 20 nm (in diameter) depending upon the elevating temperature or the addition of salt.

Style APA, Harvard, Vancouver, ISO itp.

11

Wickramarachchi, Anuradha, Vijini Mallawaarachchi, Vaibhav Rajan i Yu Lin. "MetaBCC-LR: metagenomics binning by coverage and composition for long reads". Bioinformatics 36, Supplement_1 (1.07.2020): i3—i11. http://dx.doi.org/10.1093/bioinformatics/btaa441.

Pełny tekst źródła

Streszczenie:

Abstract Motivation Metagenomics studies have provided key insights into the composition and structure of microbial communities found in different environments. Among the techniques used to analyse metagenomic data, binning is considered a crucial step to characterize the different species of micro-organisms present. The use of short-read data in most binning tools poses several limitations, such as insufficient species-specific signal, and the emergence of long-read sequencing technologies offers us opportunities to surmount them. However, most current metagenomic binning tools have been developed for short reads. The few tools that can process long reads either do not scale with increasing input size or require a database with reference genomes that are often unknown. In this article, we present MetaBCC-LR, a scalable reference-free binning method which clusters long reads directly based on their k-mer coverage histograms and oligonucleotide composition. Results We evaluate MetaBCC-LR on multiple simulated and real metagenomic long-read datasets with varying coverages and error rates. Our experiments demonstrate that MetaBCC-LR substantially outperforms state-of-the-art reference-free binning tools, achieving ∼13% improvement in F1-score and ∼30% improvement in ARI compared to the best previous tools. Moreover, we show that using MetaBCC-LR before long-read assembly helps to enhance the assembly quality while significantly reducing the assembly cost in terms of time and memory usage. The efficiency and accuracy of MetaBCC-LR pave the way for more effective long-read-based metagenomics analyses to support a wide range of applications. Availability and implementation The source code is freely available at: https://github.com/anuradhawick/MetaBCC-LR. Supplementary information Supplementary data are available at Bioinformatics online.

Style APA, Harvard, Vancouver, ISO itp.

12

Li, Huanqiang, Ziling Mai, Sijia Yu, Bo Wang, Wenguang Lai, Guanzhong Chen, Chunyun Zhou i in. "Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors’ Target Prediction". BioMed Research International 2021 (8.09.2021): 1–13. http://dx.doi.org/10.1155/2021/4229194.

Pełny tekst źródła

Streszczenie:

Background. Previous studies have shown that heart failure (HF) and chronic kidney disease (CKD) have common genetic mechanisms, overlapping pathophysiological pathways, and therapeutic drug—sodium-glucose cotransporter 2 (SGLT2) inhibitors. Methods. The genetic pleiotropy metaCCA method was applied on summary statistics data from two independent meta-analyses of GWAS comprising more than 1 million people to identify shared variants and pleiotropic effects between HF and CKD. Targets of SGLT2 inhibitors were predicted by SwissTargetPrediction and DrugBank databases. To refine all genes, we performed using versatile gene-based association study 2 (VEGAS2) and transcriptome-wide association studies (TWAS) for HF and CKD, respectively. Gene enrichment and KEGG pathway analyses were used to explore the potential functional significance of the identified genes and targets. Results. After metaCCA analysis, 4,624 SNPs and 1,745 genes were identified to be potentially pleiotropic in the univariate and multivariate SNP-multivariate phenotype analyses, respectively. 21 common genes were detected in both metaCCA and SGLT2 inhibitors’ target prediction. In addition, 169 putative pleiotropic genes were identified, which met the significance threshold both in metaCCA analysis and in the VEGAS2 or TWAS analysis for at least one disease. Conclusion. We identified novel variants associated with HF and CKD using effectively incorporating information from different GWAS datasets. Our analysis may provide new insights into HF and CKD therapeutic approaches based on the pleiotropic genes, common targets, and mechanisms by integrating the metaCCA method, TWAS and VEGAS2 analyses, and target prediction of SGLT2 inhibitors.

Style APA, Harvard, Vancouver, ISO itp.

13

Shin, Hyeong-Won, Taek-Kyun Jung, Hyo-Soo Lee i Seung-Boo Jung. "Peel strengths of the Composite Structure of Metal and Metal Oxide Laminate". Journal of the Microelectronics and Packaging Society 20, nr 4 (30.12.2013): 13–16. http://dx.doi.org/10.6117/kmeps.2013.20.4.013.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

14

Pérez, Liliana, John E. Kerrigan, Xiaojin Li i Huizhou Fan. "Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity". Biochemistry and Cell Biology 85, nr 1 (luty 2007): 141–49. http://dx.doi.org/10.1139/o06-179.

Pełny tekst źródła

Streszczenie:

Tumor necrosis factor alpha (TNF-α) converting enzyme (TACE) is a zinc metalloprotease that has emerged as a general sheddase, which is responsible for ectodomain release of numerous membrane proteins, including the proinflammatory cytokine TNF-α, the leukocyte adhesin l-selectin and epidermal growth factor receptor ligand-transforming growth factor α (TGF-α), and related family members. Structurally, TACE belongs to a large clan of proteases, designated the metzincins, because TACE possesses a conserved methionine (Met435), frequently referred to as the met-turn residue, in its active site. A vital role of this residue in the function of TACE is supported by the fact that cells expressing the M435I TACE variant are defective in ectodomain shedding. However, the importance of Met435 in TACE appears to be uncertain, since another metzincin, matrix metalloprotease-2, has been found to be enzymatically fully active with either leucine or serine in place of its met-turn residue. We constructed TACE mutants with leucine or serine in place of Met435 to further examine the role of the met-turn residue in TACE-mediated ectodomain cleavage. Similar to the M435I TACE mutant, both the M435L and M435S constructs are defective in cleaving transmembrane TNF-α, TGF-α, and l-selectin. Comparative modeling and dynamic computation detected structural perturbations, which resulted in higher energy, in the catalytic zinc complexes of the Met435 TACE mutants compared with that in the wild-type enzyme. Thus, Met435 serves to maintain the stability of the catalytic center of TACE for the hydrolysis of peptide bonds in substrates.

Style APA, Harvard, Vancouver, ISO itp.

15

Gharehkhani, Samira, Weijue Gao i Pedram Fatehi. "In-Situ Rheological Studies of Cationic Lignin Polymerization in an Acidic Aqueous System". Polymers 12, nr 12 (14.12.2020): 2982. http://dx.doi.org/10.3390/polym12122982.

Pełny tekst źródła

Streszczenie:

The chemistry of lignin polymerization was studied in the past. Insights into the rheological behavior of the lignin polymerization system would provide crucial information required for tailoring lignin polymers with desired properties. The in-situ rheological attributes of lignin polymerization with a cationic monomer, [2-(methacryloyloxy)ethyl] trimethylammonium chloride (METAC), were studied in detail in this work. The influences of process conditions, e.g., temperature, component concentrations, and shear rates, on the viscosity variations of the reaction systems during the polymerization were studied in detail. Temperature, METAC/lignin molar ratio, and shear rate increases led to the enhanced viscosity of the reaction medium and lignin polymer with a higher degree of polymerization. The extended reaction time enhanced the viscosity attributing to the larger molecular weight of the lignin polymer. Additionally, the size of particles in the reaction system dropped as reaction time was extended. The lignin polymer with a larger molecular weight and Rg behaved mainly as a viscose (tan δ > 1 or G″ > G′) material, while the lignin polymer generated with smaller molecular weight and shorter Rg demonstrated strong elastic characteristics with a tan (δ) lower than unity over the frequency range of 0.1−10 rad/s.

Style APA, Harvard, Vancouver, ISO itp.

16

He, Pei, Rong Rong Cao, Fei Yan Deng i Shu Feng Lei. "Identification of Potential Pleiotropic Genes for Immune and Skeletal Diseases Using Multivariate MetaCCA Analysis". Current Genomics 22, nr 8 (grudzień 2021): 596–606. http://dx.doi.org/10.2174/1389202923666211223115214.

Pełny tekst źródła

Streszczenie:

Background: Immune and skeletal systems physiologically and pathologically interact with each other. The immune and skeletal diseases may share potential pleiotropic genetics factors, but the shared specific genes are largely unknown Objective: This study aimed to investigate the overlapping genetic factors between multiple diseases (including rheumatoid arthritis (RA), psoriasis, osteoporosis, osteoarthritis, sarcopenia and fracture) Methods: The canonical correlation analysis (metaCCA) approach was used to identify the shared genes for six diseases by integrating genome-wide association study (GWAS)-derived summary statistics. Versatile Gene-based Association Study (VEGAS2) method was further applied to refine and validate the putative pleiotropic genes identified by metaCCA. Results: About 157 (p< 8.19E-6), 319 (p<3.90E-6) and 77 (p<9.72E-6) potential pleiotropic genes were identified shared by two immune disease, four skeletal diseases, and all of the six diseases, respectively. The top three significant putative pleiotropic genes shared by both immune and skeletal diseases, including HLA-B, TSBP1 and TSBP1-AS1 (p<E-300) were located in the major histocompatibility complex (MHC) region. Nineteen of 77 putative pleiotropic genes identified by metaCCA analysis were associated with at least one disease in the VEGAS2 analysis. Specifically, majority (18) of these 19 putative validated pleiotropic genes were associated with RA. Conclusion: The metaCCA method identified some pleiotropic genes shared by the immune and skeletal diseases. These findings help to improve our understanding of the shared genetic mechanisms and signaling pathways underlying immune and skeletal diseases.

Style APA, Harvard, Vancouver, ISO itp.

17

Yin, Luoluo. "Analysis of meta company's growth in the context of metaverse". BCP Business & Management 28 (14.10.2022): 232–40. http://dx.doi.org/10.54691/bcpbm.v28i.2243.

Pełny tekst źródła

Streszczenie:

In the context of the booming metaverse concept, Internet giant companies are sailing in a thousand directions, among which Facebook Inc. has changed its name to meta, reflecting behind its determination to expand its business landscape into the metaverse field. This paper analyses the different scenarios of meta's entry into the metaverse and uses a swot model to analyse meta's metaverse business, and concludes with some discussion of the possibilities for the company's successful future development. Meta's monopoly strategy and strong comprehensive strength can strongly help to realize the meta-universe and disruptively change users' lives, however, the potential meta-universe regulation may become a more worrying long-term threat to Meta. To make a better development, internally, seeking a second growth curve, continuously making technological breakthroughs, dealing with privacy and security issues, and building a new user ecosystem; externally, in order to better embrace the arrival of the meta-universe, appropriately adjusting the monopoly strategy and proactively helping the government find a more appropriate perspective to regulate the Internet industry may be the best way.

Style APA, Harvard, Vancouver, ISO itp.

18

Khirnyi, V. F. "Electron gas pressure in pure metals and metal superconductors". Functional materials 23, nr 3 (27.09.2016): 364–69. http://dx.doi.org/10.15407/fm23.03.364.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

19

Ourailidou, Maria E., Martijn R. H. Zwinderman i Frank J. Dekker. "Bioorthogonal metabolic labelling with acyl-CoA reporters: targeting protein acylation". MedChemComm 7, nr 3 (2016): 399–408. http://dx.doi.org/10.1039/c5md00446b.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

20

Kontopantelis, Evangelos, i David Reeves. "Pairwise meta-analysis of aggregate data using metaan in Stata". Stata Journal: Promoting communications on statistics and Stata 20, nr 3 (wrzesień 2020): 680–705. http://dx.doi.org/10.1177/1536867x20953575.

Pełny tekst źródła

Streszczenie:

A few years ago, we developed metaan, a package to perform fixedor random-effects meta-analysis. In terms of random-effects meta-analysis, it offered a wide choice of models, including maximum likelihood, profile likelihood, or restricted maximum-likelihood, in addition to the established DerSimonian–Laird method available in metan or Cochrane’s RevMan software. Other unique features included a wide range of reported heterogeneity measures and a plot of the maximum likelihood function. Since then, metaan has been continuously updated to offer improved graphics, more options, and more meta-analysis models. In this necessary update, we describe these additions and discuss the new models and the evidence behind them.

Style APA, Harvard, Vancouver, ISO itp.

21

Brunmair, Julia, Andrea Bileck, Thomas Stimpfl, Florian Raible, Giorgia Del Favero, Samuel M. Meier-Menches i Christopher Gerner. "Metabo-tip: a metabolomics platform for lifestyle monitoring supporting the development of novel strategies in predictive, preventive and personalised medicine". EPMA Journal 12, nr 2 (4.05.2021): 141–53. http://dx.doi.org/10.1007/s13167-021-00241-6.

Pełny tekst źródła

Streszczenie:

Abstract Background/aims Exposure to bioactive compounds from nutrition, pharmaceuticals, environmental contaminants or other lifestyle habits may affect the human organism. To gain insight into the effects of these influences, as well as the fundamental biochemical mechanisms behind them, individual molecular profiling seems to be a promising tool and may support the further development of predictive, preventive and personalised medicine. Methods We developed an assay, called metabo-tip for the analysis of sweat, collected from fingertips, using mass spectrometry—by far the most comprehensive and sensitive method for such analyses. To evaluate this assay, we exposed volunteers to various xenobiotics using standardised protocols and investigated their metabolic response. Results As early as 15 min after the consumption of a cup of coffee, 50 g of dark chocolate or a serving of citrus fruits, significant changes in the sweat composition of the fingertips were observed, providing relevant information in regard to the ingested substances. This included not only health-promoting bioactive compounds but also potential hazardous substances. Furthermore, the identification of metabolites from orally ingested medications such as metamizole indicated the applicability of this assay to observe specific enzymatic processes in a personalised fashion. Remarkably, we found that the sweat composition fluctuated in a diurnal rhythm, supporting the hypothesis that the composition of sweat can be influenced by endogenous metabolic activities. This was further corroborated by the finding that histamine was significantly increased in the metabo-tip assay in individuals with allergic reactions. Conclusion Metabo-tip analysis may have a large number of practical applications due to its analytical power, non-invasive character and the potential of frequent sampling, especially regarding the individualised monitoring of specific lifestyle and influencing factors. The extraordinarily rich individualised metabolomics data provided by metabo-tip offer direct access to individual metabolic activities and will thus support predictive preventive personalised medicine.

Style APA, Harvard, Vancouver, ISO itp.

22

Marichev, A. O., S. V. Datsenko, O. V. Deinega, E. A. Kabakova, E. S. Kurskova, D. M. Tashkhanov, A. M. Radovsky i in. "Etiological factors and clinical value of metabolic acidosis after cardiac surgery with cardiopulmonary bypass". Regional blood circulation and microcirculation 18, nr 3 (7.10.2019): 35–43. http://dx.doi.org/10.24884/1682-6655-2019-18-3-35-43.

Pełny tekst źródła

Streszczenie:

Aim – determine a forms of metabolic acidosis (MetAc) after cardiac surgery with cardiopulmonary bypass (CPB). Estimate signiﬁcance of MetAc in an early postoperative period.Material and methods. We included the 129 adult cardiac surgery patients. We studied the indicators of acid-base blood status, markers of systemic inﬂammation, an oxygen delivery and consumption, the hemodynamic parameters, the clinical course of the postoperative period.Results. The acid-base disorders were found in 73.6 % of cases. The metabolic acidosis was in 51.2 % of cases: the lactate acidosis was in 92.4 % and the hyperchloremic acidosis was in 7.6 %. The metabolic lactate acidosis was represented by two forms: 1. the acid-base disorders due to a low cardiac output syndrome with a decrease in oxygen delivery and contractility (14.7 %); 2. the lactate acidosis due to a systemic inﬂammatory response syndrome (49.2 % of cases). It is associated with a high delivery and a low oxygen extraction, increased cardiac output and a vasoplegia. Patients with these disorders had a higher level of leukocytosis after 24 hours of the end the operation, had a longer duration of respiratory support and a long ICU stay and hospital stay.Conclusion. The lactate acidosis is represented by two forms: the lactate acidosis associated with the low cardiac output syndrome and lactate acidosis associated with the systemic inﬂammatory response. The lactate acidosis is a predictor of adverse outcome after cardiac surgery with CPB and associated with a postoperative complications and a mortality.

Style APA, Harvard, Vancouver, ISO itp.

23

Silverman, Malcolm, i Miriam Mambrini. "A outra metade". World Literature Today 75, nr 1 (2001): 190. http://dx.doi.org/10.2307/40156509.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

24

Karp, P. D. "The MetaCyc Database". Nucleic Acids Research 30, nr 1 (1.01.2002): 59–61. http://dx.doi.org/10.1093/nar/30.1.59.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

25

Martins, Alberto. "A outra metade". Literatura e Sociedade, nr 16 (29.12.2012): 100. http://dx.doi.org/10.11606/issn.2237-1184.v0i16p100-106.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

26

Fernandes, Maria Angélica. "Democracia pela Metade". Revista Simetria do Tribunal de Contas do Município de São Paulo 1, nr 5 (21.11.2019): 18–29. http://dx.doi.org/10.61681/revistasimetria.v1i5.42.

Pełny tekst źródła

Streszczenie:

O presente apresenta os elementos constitutivos das discussões proposta pelo feminismo à sociedade, com alcance na academia, acerca da exclusão das mulheres de processos políticos e decisórios. Dessa forma, aponta como pressuposto o reconhecimento das diferenças historicamente construídas, que resultam em uma sub-representação das mulheres e de sua pauta específica. Essa exclusão foi incorporada ainda na fundação do Estado Moderno e, segundo as teóricas feministas, deu origem ao conceito incompleto de igualdade, uma vez que desconsidera as desigualdades entre os gêneros. A construção da agenda pública de política para as mulheres tem como primeiro obstáculo a sub-representação de mulheres nos espaços decisórios, em contraste com sua condição de maioria da população e do eleitorado. Apesar desse quadro, a atuação do movimento de mulheres e feminista, com impulso da agenda dos organismos multilaterais e bilaterais, abriu a possibilidade de espaços mais sensíveis a novas práticas que visam garantir a plena cidadania das mulheres. Para exemplificar essas transformações estatais promovidas nestes períodos podemos destacar os organismos para implementação de políticas públicas, as Conferências e Planos Nacionais de Políticas para as mulheres, a Lei Maria da Penha e outras medidas para enfrentar e combater as desigualdades entre os gêneros. A consolidação dessas conquistas pressupõe um ambiente democrático capaz de trazer à tona as demandas historicamente negligenciadas e secundarizadas dos setores excluídos, como no caso as mulheres.

Style APA, Harvard, Vancouver, ISO itp.

27

Moriki, Takanori, Mitsuru Murata, Tetsuya Kitaguchi, Hironobu Anbo, Makoto Handa, Kiyoaki Watanabe, Hoyu Takahashi i Yasuo Ikeda. "Expression and Functional Characterization of an Abnormal Platelet Membrane Glycoprotein Ibα (Met239 → Val) Reported in Patients With Platelet-Type von Willebrand Disease". Blood 90, nr 2 (15.07.1997): 698–705. http://dx.doi.org/10.1182/blood.v90.2.698.

Pełny tekst źródła

Streszczenie:

Abstract Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF ). Two distinct point mutations, Gly233 to Val and Met239 to Val, have been reported in GPIbα. We have constructed a recombinant GPIbα fragment containing the latter mutation, Met239 to Val (M239V) and characterized the mutant molecule using two methods, ie, interaction between soluble vWF and immobilized M239V and inhibition of platelet aggregation by purified soluble M239V. Spontaneous binding (ie, binding without any inducers) was observed between 125I-vWF and immobilized M239V but not between 125I-vWF and immobilized wild-type (WT) GPIbα. The addition of low concentrations of ristocetin (0.2 mg/mL) induced specific 125I-vWF binding to immobilized M239V, but not to WT GPIbα. At high concentrations of ristocetin (1.2 mg/mL), both WT GPIbα and M239V specifically bound to 125I-vWF. Thus, M239V reproduced the unique functional abnormality of the GPIb/IX complex in platelet-type vWD. Moreover, the purified soluble M239V inhibited platelet aggregation induced by low concentration of ristocetin (0.3 mg/mL) in platelet-rich plasma from a patient having Met239 to Val mutation, whereas purified WT did not. These results provide direct evidences that the reported point mutation is the responsible molecular basis of this disorder.

Style APA, Harvard, Vancouver, ISO itp.

28

Moriki, Takanori, Mitsuru Murata, Tetsuya Kitaguchi, Hironobu Anbo, Makoto Handa, Kiyoaki Watanabe, Hoyu Takahashi i Yasuo Ikeda. "Expression and Functional Characterization of an Abnormal Platelet Membrane Glycoprotein Ibα (Met239 → Val) Reported in Patients With Platelet-Type von Willebrand Disease". Blood 90, nr 2 (15.07.1997): 698–705. http://dx.doi.org/10.1182/blood.v90.2.698.698_698_705.

Pełny tekst źródła

Streszczenie:

Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF ). Two distinct point mutations, Gly233 to Val and Met239 to Val, have been reported in GPIbα. We have constructed a recombinant GPIbα fragment containing the latter mutation, Met239 to Val (M239V) and characterized the mutant molecule using two methods, ie, interaction between soluble vWF and immobilized M239V and inhibition of platelet aggregation by purified soluble M239V. Spontaneous binding (ie, binding without any inducers) was observed between 125I-vWF and immobilized M239V but not between 125I-vWF and immobilized wild-type (WT) GPIbα. The addition of low concentrations of ristocetin (0.2 mg/mL) induced specific 125I-vWF binding to immobilized M239V, but not to WT GPIbα. At high concentrations of ristocetin (1.2 mg/mL), both WT GPIbα and M239V specifically bound to 125I-vWF. Thus, M239V reproduced the unique functional abnormality of the GPIb/IX complex in platelet-type vWD. Moreover, the purified soluble M239V inhibited platelet aggregation induced by low concentration of ristocetin (0.3 mg/mL) in platelet-rich plasma from a patient having Met239 to Val mutation, whereas purified WT did not. These results provide direct evidences that the reported point mutation is the responsible molecular basis of this disorder.

Style APA, Harvard, Vancouver, ISO itp.

29

Martine, George. "O Cairo pela metade". Revista Brasileira de Estudos de População 36 (3.12.2019): 1–7. http://dx.doi.org/10.20947/s0102-3098a0093.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

30

Guerra Leal, Izabela Guimarães, i Marina Beatrice Ferreira Farias. "A questão da identidade em "Metade cara, metade máscara" de Eliane Potiguara". Caletroscópio 8, nr 1 (23.07.2020): 11–22. http://dx.doi.org/10.58967/caletroscopio.v8.n1.2020.4046.

Pełny tekst źródła

Streszczenie:

Este trabalho se propõe a discutir a poesia de Eliane Potiguara presente no livro Metade cara, metade máscara (2018), primeiro livro publicado por uma mulher indígena de modo individualizado no Brasil. Sabe-se que a poética indígena existe e resiste na tradição oral, enraizada nas práticas de vida de inúmeros povos originários. Porém, no caso de Eliane Potiguara, seus antepassados migraram das terras tradicionais da etnia Potiguara, no atual estado da Paraíba, para o Rio de Janeiro, por conta das invasões de terra, portanto ela nasceu em um contexto social fora das terras tradicionais. Nesse sentido, o livro de Potiguara narra a história vivida pelas mulheres de sua família ao longo do processo de colonização, e também utiliza a escrita poética como forma de libertação, seja pelo expurgo da dor ou pelo resgate da espiritualidade indígena, outrora repassada pela sua avó. A questão da identidade é discutida em vários poemas, inclusive no título do livro, e é analisada nesse trabalho com base em O local da cultura (2005), de Homi K. Bhabha, cuja análise da obra de Frantz Fanon dialoga com os poemas de Eliane. Os poemas analisados neste trabalho são “O criador, a identidade e o guerreiro”, “Identidade indígena”, “Brasil”, “Mulher”, “Terra-mulher” e “Terra-cunhã”.

Style APA, Harvard, Vancouver, ISO itp.

31

SASAKI, G., K. MASTUGI i O. YANAGISAWA. "MMC-03: Anodic Bonding and its Interfacial Reaction between Metals and Ionic Conductor(MMC-I: METALS AND METAL MATRIX COMPOSITES)". Proceedings of the JSME Materials and Processing Conference (M&P) 2005 (2005): 4. http://dx.doi.org/10.1299/jsmeintmp.2005.4_5.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

32

Lima, Débora Francisca de. "Memória e ancestralidade em poemas de "metade cara, metade máscara", de Eliane Potiguara". Revista Diadorim 24, nr 1 (1.01.2022): 408–22. http://dx.doi.org/10.35520/diadorim.2022.v24n1a48876.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

33

Kövesdán, Gábor, i László Lengyel. "Meta3: a code generator framework for domain-specific languages". Software & Systems Modeling 18, nr 4 (29.03.2018): 2421–39. http://dx.doi.org/10.1007/s10270-018-0673-6.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

34

Kohno, H., W. P. Bocchinfuso, O. Gandini, S. W. Curtis i K. S. Korach. "Mutational analysis of the estrogen receptor ligand-binding domain: influence of ligand structure and stereochemistry on transactivation". Journal of Molecular Endocrinology 16, nr 3 (czerwiec 1996): 277–85. http://dx.doi.org/10.1677/jme.0.0160277.

Pełny tekst źródła

Streszczenie:

ABSTRACT The mouse estrogen receptor (mER) exhibits ligand stereochemical specificity for indenestrol A (IA), a stilbestrol estrogen. IA has a chiral C3 methyl group, and the mER preferentially binds the S-enantiomer (IA-S), resulting in elevated biological activity when compared with the IA-R enantiomer. To elucidate the mechanisms for this stereochemical recognition, we have constructed a series of mERs with individual amino acid substitutions at Met521, His528, Met532, and Val537. The abilities of yeast-expressed wild-type and mutant mERs to transactivate an estrogenresponsive reporter gene construct were measured in the presence of diethylstilbestrol (DES) and IA enantiomers. The concentration of IA-S required to induce half-maximal transactivation by wild-type mER was 10-fold lower than IA-R, which is attributed to the 15-fold greater binding affinity for IA-S. Wild-type mER displayed similar dose—response curves for IA-R and demethyl IA, which lacks a C3 methyl group, demonstrating that the presence and correct orientation of the C3 methyl group on the IA compound is required for high-affinity ligand binding and transcriptional activity. Each mutant exhibited a reduced preference for IA-S enantiomer with respect to transactivation, suggesting that this region of the mER functions in ligand stereochemical recognition and activation. A mutation at Met532 diminished DES-and IA-S-induced transactivation by 7·5-fold and 40-fold respectively, with minimal change on their binding affinity. These data suggest that Met532 is required for transactivation induced by the potent agonist, IA-S, and the M532G mutation effectively uncouples IA-S ligand binding from transactivation. Use of these stereochemically different ligands in combination with mutagenesis of the mER demonstrates that ligand structure could influence transactivation by specifically altering the conformation of the mER AF-2 region.

Style APA, Harvard, Vancouver, ISO itp.

35

HUH, S. C., W. J. PARK i S. H. PARK. "MMC-11: Evaluation of Design Strength and Residual Stress in Ceramic/Metal Joint(MMC-II: METALS AND METAL MATRIX COMPOSITES)". Proceedings of the JSME Materials and Processing Conference (M&P) 2005 (2005): 10. http://dx.doi.org/10.1299/jsmeintmp.2005.10_1.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

36

Brum, Bruno. "Metade da minha obra completa". Txt: Leituras Transdisciplinares de Telas e Textos 1, nr 2 (31.12.2005): 77. http://dx.doi.org/10.17851/1809-8150.1.2.77-78.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

37

Karp, P. D. "The EcoCyc and MetaCyc databases". Nucleic Acids Research 28, nr 1 (1.01.2000): 56–59. http://dx.doi.org/10.1093/nar/28.1.56.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

38

Kontopantelis, Evangelos, i David Reeves. "Metaan: Random-effects Meta-analysis". Stata Journal: Promoting communications on statistics and Stata 10, nr 3 (wrzesień 2010): 395–407. http://dx.doi.org/10.1177/1536867x1001000307.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

39

Paranhos, Will. "“Não posso ser pela metade”". Revista Periódicus 2, nr 19 (6.12.2023): 20–48. http://dx.doi.org/10.9771/peri.v2i19.49627.

Pełny tekst źródła

Streszczenie:

O presente artigo tem como objetivo articular a contribuição da vivência plena das diferenças, em suas intersecções, com a promoção do senso de pertencimento às organizações e da integralidade das existências. A pesquisa se baseia em referenciais que congreguem os conceitos de pertencimento, plenitude e integralidade com as categorias de diferenças e diversidades. O desenvolvimento é orientado pelo método cartográfico, tendo-se realizado entrevistas semiestruturadas com pessoas pertencentes a algum grupo minorizado e que estejam atuantes em alguma organização. Os resultados mostram que, por mais que existam ações para a inclusão das diversidades nas organizações, as pessoas não se sentem pertencentes aos espaços, haja vista o fato de não serem percebidas em suas interseccionalidades. Outro fato evidenciado se liga ao fenômeno da “superinclusão”, prática universalista que busca afirmar que todas as pessoas são iguais, gerando um apagamento das diferenças.

Style APA, Harvard, Vancouver, ISO itp.

40

Guo, Yugang, Qianwen Xu, Lei Xue, Erling Chen, Chonglin Liu, Min Gao, Youjia Li i in. "Abstract LB236: Metabolically armed CD19 CAR-T cells for safe and effective treatment of relapsed or refractory CD19+ B cell hematological malignancies at extremely low doses". Cancer Research 84, nr 7_Supplement (5.04.2024): LB236. http://dx.doi.org/10.1158/1538-7445.am2024-lb236.

Pełny tekst źródła

Streszczenie:

Abstract Background: The undeniable success of CD19 CAR-T cell therapy in managing relapsed or refractory (r/r) B-cell hematological malignancies, such as diffuse large B-cell lymphoma (DLBCL) and B-cell acute lymphoblastic leukemia (B-ALL), underscores its significance. Despite the favorable complete remission (CR) rates of around 50% for r/r DLBCL and up to 90% for r/r B-ALL, a notable challenge persists as more than half of patients experiencing CR after CD19 CAR-T cells treatment encounter relapse within a year, attributed to inadequate CAR-T persistence in both indications. Urgent attention is required to devise innovative strategies to overcome these challenges. Recently, we developed metabolically armed CD19 CAR-T cells expressing IL-10 can enhance OXPHOS metabolism, proliferation, and persistence of CAR-T cells in vivo. Significantly, these IL-10-expressing CAR-T cells trigger stem-like memory responses in various lymphoid organs, leading to robust tumor eradication and durable protection. Motivated by these promising findings, an open-label, single arm, investigator-initiated trial (IIT, ClinicalTrials.gov identifier: NCT05715606, NCT05747157) was conducted to assess the safety and efficacy of newly developed metabolically armed IL-10-expressing CD19 CAR-T (product name: Meta10-19 infusion) for treating patients with r/r DLBCL or r/r B-ALL. Method: From Feb 2023 to Dec 2023, this IIT clinical trial evaluated Meta10-19 infusion in adult patients with r/r DLBCL or r/r B-ALL. The patients were recruited and treated at the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China. Patients in 3 dose cohorts (2.0 × 104, 5.0 × 104, or 1.0 × 105 CAR-T cells/kg, corresponding to 1%, 2.5%, or 5% doses of commercialized CAR-T infusion) underwent lymphodepleting chemotherapy with cyclophosphamide and fludarabine before Meta10-19 infusion. The primary endpoint was the incidence of dose-limiting toxicities. The secondary endpoint was the response and survival. Results: The treatment with Meta10-19 infusion has successfully induced CR in all 12 cases of r/r DLBCL (n=6) or r/r B-ALL (n=6), as evaluated by PET-CT scan, NMR spectroscopy or minimal residual disease assessment of bone marrow. No server cytokine storm syndrome or neurotoxicity was observed. All treated patients achieved CR at 3 months post treatment, with the first patient maintaining continuous remission up to 9 months until now. Notably, these metabolically armed CD19 CAR-T cells demonstrated efficacy even for patients with bulky mass (≥7.5 cm) of DLBCL at extremely low infusion dose (1~5% doses of commercialized CAR-T). Conclusion: Preliminary findings suggest that Meta10-19 infusion exhibits promising breakthrough efficacy and safety profile, and active enrollment is ongoing to validate the initial results. Citation Format: Yugang Guo, Qianwen Xu, Lei Xue, Erling Chen, Chonglin Liu, Min Gao, Youjia Li, Jingjing Ren, Jinping Li, Li Tang, Xingbing Wang. Metabolically armed CD19 CAR-T cells for safe and effective treatment of relapsed or refractory CD19+ B cell hematological malignancies at extremely low doses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB236.

Style APA, Harvard, Vancouver, ISO itp.

41

Silva Filho, Joel Vieira da, i Cristian Souza de Sales. "Metade cara, metade máscara: memória coletiva e identidade indígena na obra de Eliane Potiguara". Boitatá 15, nr 30 (20.12.2021): 62. http://dx.doi.org/10.5433/boitata.2020v15.e41320.

Pełny tekst źródła

Streszczenie:

Este texto investe numa discussão acerca das relações existentes entre memória coletiva e identidade indígena em Metade Cara, Metade Máscara (2004) da escritora indígena contemporânea Eliane Potiguara. Metade Cara, Metade Máscara é uma obra de cunho autobiográfico, de gênero híbrido, entremeando lendas, ficção, testemunhos, depoimentos e poemas. Através da narrativa de deslocamento e processo diaspórico da escritora, destacamos como as memórias individual, coletiva e as identidades se incorporam e se encenam poeticamente. O trabalho evidencia como os poemas operam em favor da preservação da memória coletiva e da identidade dos povos indígenas. Na poética da escritora, as memórias e identidades performadas dão sustentação a outros saberes sobre os povos indígenas, os quais se diferenciam das versões disseminadas pelas epistemologias eurocentradas. Por fim, o texto realiza um estudo teórico-crítico que dialoga com os seguintes autores: Halbwachs (1990); Hall (2006); Munduruku (2018), entre outros.

Style APA, Harvard, Vancouver, ISO itp.

42

Da Silva, Neuza Maria Correa, i Dóris Helena Soares da Silva Giacomolli. "DISCURSO E RESISTÊNCIA NA OBRA POÉTICA DE ELIANE POTIGUARA EM METADE CARA, METADE MÁSCARA". Revista Contrapontos 19, nr 1 (26.09.2019): 314. http://dx.doi.org/10.14210/contrapontos.v19n1.p314-327.

Pełny tekst źródła

Streszczenie:

Este artigo tem por intuito articular uma reflexão acerca de questões imanentes ao discurso exarado no livro Metade cara, metade máscara. Pretendemos acentuar as regularidades arquivadas nas formações discursivas que atravessam a fala de Eliane Potiguara, norteiam sua poesia e sua palavra em movimento, nos norteando pelos teóricos Michel Foucault e Eni Orlandi para, a partir da fala de Potiguara, observarmos a ordem discursiva que a interpela. Pretendemos observar em que sujeito ela se converte ao tomar posse da palavra e dar vazão ao viver dos povos indígenas brasileiros. Pela análise da referida obra, percebemos que Potiguara vem, por meio de seu discurso poético, autobiográfico ou em forma de escrita jornalística de informação, exaltar a determinação e a firmeza da luta dos povos originários.

Style APA, Harvard, Vancouver, ISO itp.

43

Yang, Sung-Jae, Byoung-Chul Min, Young-Wan Kim, Sang-Mok Jang, Byong-Hoon Lee i Kwan-Hwa Park. "Changes in the Catalytic Properties of Pyrococcus furiosus Thermostable Amylase by Mutagenesis of the Substrate Binding Sites". Applied and Environmental Microbiology 73, nr 17 (13.07.2007): 5607–12. http://dx.doi.org/10.1128/aem.00499-07.

Pełny tekst źródła

Streszczenie:

ABSTRACT Pyrococcus furiosus thermostable amylase (TA) is a cyclodextrin (CD)-degrading enzyme with a high preference for CDs over maltooligosaccharides. In this study, we investigated the roles of four residues (His414, Gly415, Met439, and Asp440) in the function of P. furiosus TA by using site-directed mutagenesis and kinetic analysis. A variant form of P. furiosus TA containing two mutations (H414N and G415E) exhibited strongly enhanced α-(1,4)-transglycosylation activity, resulting in the production of a series of maltooligosaccharides that were longer than the initial substrates. In contrast, the variant enzymes with single mutations (H414N or G415E) showed a substrate preference similar to that of the wild-type enzyme. Other mutations (M439W and D440H) reversed the substrate preference of P. furiosus TA from CDs to maltooligosaccharides. Relative substrate preferences for maltoheptaose over β-CD, calculated by comparing k cat/Km ratios, of 1, 8, and 26 for wild-type P. furiosus TA, P. furiosus TA with D440H, and P. furiosus TA with M439W and D440H, respectively, were found. Our results suggest that His414, Gly415, Met439, and Asp440 play important roles in substrate recognition and transglycosylation. Therefore, this study provides information useful in engineering glycoside hydrolase family 13 enzymes.

Style APA, Harvard, Vancouver, ISO itp.

44

Hartiwisidi, Nurcahya, Eka Damayanti, Musdalifah Musdalifah, Ulfiani Rahman, Suarga Suarga i M. Shabir U. "Penguatan pendidikan karakter berbasis kearifan lokal Mandar Metabe’ dan Mepuang di SDN 001 Campalagian". Jurnal Pendidikan Karakter 13, nr 2 (31.10.2022): 150–62. http://dx.doi.org/10.21831/jpka.v13i2.48473.

Pełny tekst źródła

Streszczenie:

This study aims to strengthen character education based on the local wisdom of Mandar Metabe' and Mepuang at State Elementary School 001 Campalagian Polewali Mandar, West Sulawesi. Researchers try to examine more deeply the management of programs that have been made starting from planning, implementation, and evaluation. This research is a qualitative descriptive study with an ethnographic approach and was compiled using primary and secondary data. In this study, researchers used the concept of local wisdom of Mandar culture and character education strengthening programs in linking existing theories and facts. Through this research it can be seen that there are four programs of character education strengthening compiled by SDN 001 Campalagian which are carried out through learning methods and routine activities (habituation), namely (1) one day speaking Mandarin, (2) greeting the teacher with the nickname Puang as a form of habituation of respecting elders, (3) integration of local wisdom material which is carried out during the learning process by inserting local wisdom material such as the virtues of Metabe' and Mepuang, and (4) ibda' bi nafsika which means starting from oneself which is done by giving examples of commendable behavior from the teacher towards students.

Style APA, Harvard, Vancouver, ISO itp.

45

Wang, Shoujuan, Mohan K. R. Konduri, Qingxi Hou i Pedram Fatehi. "Cationic xylan–METAC copolymer as a flocculant for clay suspensions". RSC Advances 6, nr 46 (2016): 40258–69. http://dx.doi.org/10.1039/c6ra05223a.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

46

Ncube, Efficient N., Lungile Sitole, Paul A. Steenkamp, Lucia H. Steenkamp i Ian A. Dubery. "Untargeted Metabolomics Exploration of the Growth Stage-Dependent Chemical Space of the Sclareol-Converting Biocatalyst Hyphozyma roseonigra". Catalysts 12, nr 10 (13.10.2022): 1225. http://dx.doi.org/10.3390/catal12101225.

Pełny tekst źródła

Streszczenie:

Hyphozyma roseonigra is a dimorphic yeast used as a biocatalyst to convert sclareol, a plant diterpenoid to ambradiol. The latter is an intermediate in the synthesis of ambrafuran, a high-value chemical in the fragrance industry. Unfortunately, little is known about the underlying biochemistry of this microorganism. In this study, the integration of multi-platform-based metabolomics was used to better comprehend H. roseonigra from a biochemical perspective. The focus on metabolomic changes during growth and development was accomplished using untargeted LC–MS and NMR analyses. Cell suspensions were grown in batch culture over a 14-day period, and cells from the early-, log-, and stationary phases were harvested every second day using platform-compatible extraction procedures. Following chemometric analysis of LC–MS and NMR data acquired from both intra- and extracellular extracts, the identified discriminatory ions annotated from the endo- and exometabolomes (metabo-fingerprinting and metabo-footprinting) were found to fall predominantly in the primary metabolism class. Pathway mapping and feature-based network correlation analysis assisted in gaining insights into the active metabolic pathways during growth and development and did not flag terpene synthesis. This study provides novel insights into the basic metabolic capabilities of H. roseonigra and suggests that sclareol is metabolized as the detoxification of a hydrophobic xenobiotic compound.

Style APA, Harvard, Vancouver, ISO itp.

47

Bonfim, Gabriel Augusto de Paula. "O homem que era só metade". Palíndromo 12, nr 26 (1.01.2020): 279–95. http://dx.doi.org/10.5965/2175234612262020279.

Pełny tekst źródła

Streszczenie:

RESUMOO presente ensaio visual é composto pelo trabalho intitulado “O homem que era só metade”; nele articulam-se processos de criação no campo da Arte Contemporânea que exploram as possibilidades do corpo e do objeto no espaço urbano e as trocas que podem ser estabelecidas entre as potencialidades do espaço e a subjetividade humana.Palavras-chave: Corpo. Espaço Urbano. Identidade. Performance. ABSTRACTThis visual essay is composed by the work called “The Man Who Was Just a Half”, in which processes of creation in the Contemporary Arts are articulated, exploring the possibilities of the body and object in the urban space and the exchanges that can be established between the potentialities of space and human subjectivity.Keywords: Body. Urban Space. Identity. Performance. RÉSUMÉ Le présent essai visuel est composé pour le travail “L'homme qui n'était qu'une moitié”, où s'articulent procédure de création dans le champ de l'art contemporain qui exploitent les possibilités du corps et d'objet dans l'espace urbain et les échanges qui peuvent être établies parmi les potentialités d'espace et la subjectivité humaine.Mots clefs: Corps. Espace urbain. Identité. Performance.

Style APA, Harvard, Vancouver, ISO itp.

48

Boyle, Craig, i Antonio O. Encarnacion. "Metadoc: An adaptive hypertext reading system". User Modelling and User-Adapted Interaction 4, nr 1 (1994): 1–19. http://dx.doi.org/10.1007/bf01142355.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

49

Maranas, Costas D., i Anthony P. Burgard. "Review of EcoCyc and MetaCyc Databases". Metabolic Engineering 3, nr 2 (kwiecień 2001): 98–99. http://dx.doi.org/10.1006/mben.2001.0180.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

50

Kang, Dongwan D., Etienne Sibille, Naftali Kaminski i George C. Tseng. "MetaQC: objective quality control and inclusion/exclusion criteria for genomic meta-analysis". Nucleic Acids Research 40, nr 2 (23.11.2011): e15-e15. http://dx.doi.org/10.1093/nar/gkr1071.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

Artykuły w czasopismach na temat „Meta3C”

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych