Gotowe bibliografie tematyczne / Mesoporous Materials -Bioactive Pharmaceuticals -

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Gotowa bibliografia na temat „Mesoporous Materials -Bioactive Pharmaceuticals -”

Autor: Grafiati

Data publikacji: 7 września 2023

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Artykuły w czasopismach na temat "Mesoporous Materials -Bioactive Pharmaceuticals -"

Salinas, Antonio J., i Pedro Esbrit. "Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí’s Contribution". Pharmaceutics 14, nr 1 (15.01.2022): 202. http://dx.doi.org/10.3390/pharmaceutics14010202.

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Throughout her impressive scientific career, Prof. María Vallet-Regí opened various research lines aimed at designing new bioceramics, including mesoporous bioactive glasses for bone tissue engineering applications. These bioactive glasses can be considered a spin-off of silica mesoporous materials because they are designed with a similar technical approach. Mesoporous glasses in addition to SiO2 contain significant amounts of other oxides, particularly CaO and P2O5 and therefore, they exhibit quite different properties and clinical applications than mesoporous silica compounds. Both materials exhibit ordered mesoporous structures with a very narrow pore size distribution that are achieved by using surfactants during their synthesis. The characteristics of mesoporous glasses made them suitable to be enriched with various osteogenic agents, namely inorganic ions and biopeptides as well as mesenchymal cells. In the present review, we summarize the evolution of mesoporous bioactive glasses research for bone repair, with a special highlight on the impact of Prof. María Vallet-Regí´s contribution to the field.

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Purcăreanu, Bogdan, Manuela Diana Ene, Alina Moroșan, Dan Eduard Mihaiescu, Mihai Alexandru Florea, Adelina Ghica, Roxana Andreea Nita i in. "Mesoporous Composite Bioactive Compound Delivery System for Wound-Healing Processes". Pharmaceutics 15, nr 9 (31.08.2023): 2258. http://dx.doi.org/10.3390/pharmaceutics15092258.

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Currently, the treatment of wounds is still a challenge for healthcare professionals due to high complication incidences and social impacts, and the development of biocompatible and efficient medicines remains a goal. In this regard, mesoporous materials loaded with bioactive compounds from natural extracts have a high potential for wound treatment due to their nontoxicity, high loading capacity and slow drug release. MCM-41-type mesoporous material was synthesized by using sodium trisilicate as a silica source at room temperature and normal pressure. The synthesized mesoporous silica was characterized by using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), N2 absorption–desorption (BET), Dynamic Light Scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR), revealing a high surface area (BET, 1244 m2/g); pore diameter of approx. 2 nm; and a homogenous, ordered and hexagonal geometry (TEM images). Qualitative monitoring of the desorption degree of the Salvia officinalis (SO) extract, rich in ursolic acid and oleanolic acid, and Calendula officinalis (CO) extract, rich in polyphenols and flavones, was performed via the continuous recording of the UV-VIS spectra at predetermined intervals. The active ingredients in the new composite MCM-41/sage and marigold (MCM-41/SO&CO) were quantified by using HPLC-DAD and LC-MS-MS techniques. The evaluation of the biological composites’ activity on the wound site was performed on two cell lines, HS27 and HaCaT, naturally involved in tissue-regeneration processes. The experimental results revealed the ability to stimulate collagen biosynthesis, the enzymatic activity of the main metalloproteinases (MMP-2 and MMP-9) involved in tissue remodeling processes and the migration rate in the wound site, thus providing insights into the re-epithelializing properties of mesoporous composites.

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Chang, Lan, Yaqin Liu i Chengtie Wu. "Copper-Doped Mesoporous Bioactive Glass for Photothermal Enhanced Chemotherapy". Journal of Biomedical Nanotechnology 14, nr 4 (1.04.2018): 786–94. http://dx.doi.org/10.1166/jbn.2018.2542.

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Nakiou, Eirini A., Maria Lazaridou, Georgia K. Pouroutzidou, Anna Michopoulou, Ioannis Tsamesidis, Liliana Liverani, Marcela Arango-Ospina i in. "Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications". Polymers 14, nr 22 (19.11.2022): 5028. http://dx.doi.org/10.3390/polym14225028.

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Background: Aliphatic polyesters are widely used for biomedical, pharmaceutical and environmental applications due to their high biodegradability and cost-effective production. Recently, star and hyperbranched polyesters based on glycerol and ω-carboxy fatty diacids have gained considerable interest. Succinic acid and bio-based diacids similar to glycerol are regarded as safe materials according to the US Food and Drug Administration (FDA). Bioactive glass scaffolds utilized in bone tissue engineering are relatively brittle materials. However, their mechanical properties can be improved by using polymer coatings that can further control their degradation rate, tailor their biocompatibility and enhance their performance. The purpose of this study is to explore a new biopolyester poly(glycerol succinate) (PGSuc) reinforced with mesoporous bioactive nanoparticles (MSNs) as a novel coating material to produce hybrid scaffolds for bone tissue engineering. Methods: Bioactive glass scaffolds were coated with neat PGSuc, PGSuc loaded with dexamethasone sodium phosphate (DexSP) and PGSuc loaded with DexSP-laden MSNs. The physicochemical, mechanical and biological properties of the scaffolds were also evaluated. Results: Preliminary data are provided showing that polymer coatings with and without MSNs improved the physicochemical properties of the 1393 bioactive glass scaffolds and increased the ALP activity and alizarin red staining, suggesting osteogenic differentiation potential when cultured with adipose-derived mesenchymal stem cells. Conclusions: PGSuc with incorporated MSNs coated onto 1393 bioactive glass scaffolds could be promising candidates in bone tissue engineering applications.

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Munir, Arooj, Danijela Marovic, Liebert Parreiras Nogueira, Roger Simm, Ali-Oddin Naemi, Sander Marius Landrø, Magnus Helgerud i in. "Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites". Pharmaceutics 14, nr 10 (20.10.2022): 2241. http://dx.doi.org/10.3390/pharmaceutics14102241.

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Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant. Surface micromorphology and elemental analysis were performed to evaluate the homogeneous distribution of filler particles. The study investigated the effects of Cu-MBGN on the degree of conversion, polymerization shrinkage, porosity, ion release and anti-bacterial activity on S. mutans and A. naeslundii. Experimental materials containing Cu-MBGN showed a dose-dependent Cu release with an initial burst and a further increase after 28 days. The composite containing 10% Cu-MBGN had the best anti-bacterial effect on S. mutans, as evidenced by the lowest adherence of free-floating bacteria and biofilm formation. In contrast, the 45S5-containing materials had the highest S. mutans adherence. Ca release was highest in the bioactive control containing 15% 45S5, which correlated with the highest number of open porosities on the surface. Polymerization shrinkage was similar for all tested materials, ranging from 3.8 to 4.2%, while the degree of conversion was lower for Cu-MBGN materials. Cu-MBGN composites showed better anti-bacterial properties than composites with 45S5 BG.

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Ilyas, Kanwal, Lamia Singer, Muhammad Akhtar, Christoph Bourauel i Aldo Boccaccini. "Boswellia sacra Extract-Loaded Mesoporous Bioactive Glass Nano Particles: Synthesis and Biological Effects". Pharmaceutics 14, nr 1 (5.01.2022): 126. http://dx.doi.org/10.3390/pharmaceutics14010126.

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Bioactive glasses (BGs) are being increasingly considered for numerous biomedical applications. The loading of natural compounds onto BGs to increase the BG biological activity is receiving increasing attention. However, achieving efficient loading of phytotherapeutic compounds onto the surface of bioactive glass is challenging. The present work aimed to prepare novel amino-functionalized mesoporous bioactive glass nanoparticles (MBGNs) loaded with the phytotherapeutic agent Boswellia sacra extract. The prepared amino-functionalized MBGNs showed suitable loading capacity and releasing time. MBGNs (nominal composition: 58 wt% SiO2, 37 wt% CaO, 5 wt% P2O5) were prepared by sol-gel-modified co-precipitation method and were successfully surface-modified by using 3-aminopropyltriethoxysilane (APTES). In order to evaluate MBGNs loaded with Boswellia sacra, morphological analysis, biological studies, physico-chemical and release studies were performed. The successful functionalization and loading of the natural compound were confirmed with FTIR, zeta-potential measurements and UV-Vis spectroscopy, respectively. Structural and morphological evaluation of MBGNs was done by XRD, SEM and BET analyses, whereas the chemical analysis of the plant extract was done using GC/MS technique. The functionalized MBGNs showed high loading capacity as compared to non-functionalized MBGNs. The release studies revealed that Boswellia sacra molecules were released via controlled diffusion and led to antibacterial effects against S. aureus (Gram-positive) bacteria. Results of cell culture studies using human osteoblastic-like cells (MG-63) indicated better cell viability of the Boswellia sacra-loaded MBGNs as compared to the unloaded MBGNs. Therefore, the strategy of combining the properties of MBGNs with the therapeutic effects of Boswellia sacra represents a novel, convenient step towards the development of phytotherapeutic-loaded antibacterial, inorganic materials to improve tissue healing and regeneration.

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Simanek, Eric E. "Two Decades of Triazine Dendrimers". Molecules 26, nr 16 (6.08.2021): 4774. http://dx.doi.org/10.3390/molecules26164774.

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For two decades, methods for the synthesis and characterization of dendrimers based on [1,3,5]-triazine have been advanced by the group. Motivated by the desire to generate structural complexity on the periphery, initial efforts focused on convergent syntheses, which yielded pure materials to generation three. To obtain larger generations of dendrimers, divergent strategies were pursued using iterative reactions of monomers, sequential additions of triazine and diamines, and ultimately, macromonomers. Strategies for the incorporation of bioactive molecules using non-covalent and covalent strategies have been explored. These bioactive materials included small molecule drugs, peptides, and genetic material. In some cases, these constructs were examined in both in vitro and in vivo models with a focus on targeting prostate tumor subtypes with paclitaxel conjugates. In the materials realm, the use of triazine dendrimers anchored on solid surfaces including smectite clay, silica, mesoporous alumina, polystyrene, and others was explored for the separation of volatile organics from gas streams or the sequestration of atrazine from solution. The combination of these organics with metal nanoparticles has been probed. The goal of this review is to summarize these efforts.

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Gonzalez, Gema, Amaya Sagarzazu i Tamara Zoltan. "Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules". Journal of Drug Delivery 2013 (6.08.2013): 1–8. http://dx.doi.org/10.1155/2013/803585.

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Meso- and nanoporous structures are adequate matrices for controlled drug delivery systems, due to their large surface areas and to their bioactive and biocompatibility properties. Mesoporous materials of type SBA-15, synthesized under different pH conditions, and zeolite beta were studied in order to compare the different intrinsic morphological characteristics as pore size, pore connectivity, and pore geometry on the drug loading and release process. These materials were characterized by X-ray diffraction, nitrogen adsorption, scanning and transmission electron microscopy, and calorimetric measurements. Ibuprofen (IBU) was chosen as a model drug for the formulation of controlled-release dosage forms; it was impregnated into these two types of materials by a soaking procedure during different periods. Drug loading and release studies were followed by UV-Vis spectrophotometry. All nano- and mesostructured materials showed a similar loading behavior. It was found that the pore size and Al content strongly influenced the release process. These results suggest that the framework structure and architecture affect the drug adsorption and release properties of these materials. Both materials offer a good potential for a controlled delivery system of ibuprofen.

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Tsamesidis, Ioannis, Anna Theocharidou, Anastasia Beketova, Maria Bousnaki, Iason Chatzimentor, Georgia K. Pouroutzidou, Dimitrios Gkiliopoulos i Eleana Kontonasaki. "Artemisinin Loaded Cerium-Doped Nanopowders Improved In Vitro the Biomineralization in Human Periodontal Ligament Cells". Pharmaceutics 15, nr 2 (15.02.2023): 655. http://dx.doi.org/10.3390/pharmaceutics15020655.

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Background: A promising strategy to enhance bone regeneration is the use of bioactive materials doped with metallic ions with therapeutic effects and their combination with active substances and/or drugs. The aim of the present study was to investigate the osteogenic capacity of human periodontal ligament cells (hPDLCs) in culture with artemisinin (ART)-loaded Ce-doped calcium silicate nanopowders (NPs); Methods: Mesoporous silica, calcium-doped and calcium/cerium-doped silicate NPs were synthesized via a surfactant-assisted cooperative self-assembly process. Human periodontal ligament cells (hPDLCs) were isolated and tested for their osteogenic differentiation in the presence of ART-loaded and unloaded NPs through alkaline phosphatase (ALP) activity and Alizarine red S staining, while their antioxidant capacity was also evaluated; Results: ART promoted further the osteogenic differentiation of hPDLCs in the presence of Ce-doped NPs. Higher amounts of Ce in the ART-loaded NPs inversely affected the mineral deposition process by the hPDLCs. ART and Ce in the NPs have a synergistic role controlling the redox status and reducing ROS production from the hPDLCs; Conclusions: By monitoring the Ce amount and ART concentration, mesoporous NPs with optimum properties can be developed towards bone tissue regeneration demonstrating also potential application in periodontal tissue regeneration strategies.

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Carrozza, Debora, Gianluca Malavasi i Erika Ferrari. "Very Large Pores Mesoporous Silica as New Candidate for Delivery of Big Therapeutics Molecules, Such as Pharmaceutical Peptides". Materials 16, nr 11 (2.06.2023): 4151. http://dx.doi.org/10.3390/ma16114151.

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The synthesis of a scaffold that can accommodate big molecules with a pharmaceutical role is important to shield them and maintain their biological activity. In this field, silica particles with large pores (LPMS) are innovative supports. Large pores allow for the loading of bioactive molecules inside the structure and contemporarily their stabilization and protection. These purposes cannot be achieved using classical mesoporous silica (MS, pore size 2–5 nm), because their pores are not big enough and pore blocking occurs. LPMSs with different porous structures are synthesized starting from an acidic water solution of tetraethyl orthosilicate reacting with pore agents (Pluronic® F127 and mesitylene), performing hydrothermal and microwave-assisted reactions. Time and surfactant optimization were performed. Loading tests were conducted using Nisin as a reference molecule (polycyclic antibacterial peptide, with dimensions of 4–6 nm); UV-Vis analyses on loading solutions were performed. For LPMSs, a significantly higher loading efficiency (LE%) was registered. Other analyses (Elemental Analysis, Thermogravimetric Analysis and UV-Vis) confirmed the presence of Nisin in all the structures and its stability when loaded on them. LPMSs showed a lower decrease in specific surface area if compared to MS; in terms of the difference in LE% between samples, it is explained considering the filling of pores for LPMSs, a phenomenon that is not allowed for MSs. Release studies in simulated body fluid highlight, only for LPMSs, a controlled release, considering the longer time scale of release. Scanning Electron Microscopy images acquired before and after release tests shows the LPMSs’ maintenance of the structure, demonstrating strength and mechanical resistance of structures. In conclusion, LPMSs were synthesized, performing time and surfactant optimization. LPMSs showed better loading and releasing properties with respect to classical MS. All collected data confirm a pore blocking for MS and an in-pore loading for LPMS.

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Rozprawy doktorskie na temat "Mesoporous Materials -Bioactive Pharmaceuticals -"

Mattiasson, Johanna. "Method development of an in vitro vertical Franz diffusion cell system to assess permeation of cosmetic active ingredients". Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414205.

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For evaluation of potential skincare ingredients, an in-house method using Static Franz diffusion cells and dialysis membranes was developed. Benzoic acid was chosen as a model substance along with L-ascorbic acid and α-Tocopherol. The cell conditions were tailored to encourage transmembrane diffusion. Benzoic acid was tested in acetate buffer (pH 4.6), which yielded a maximum flux of 0.91 ± 0.03 mg ∙ cm-2 ∙ h-1 and absorption of 103 ± 4 % out of the applied dose after 8 h. There were strong indications that benzoic acid ionization must be suppressed by lower pH to increase penetration rates. L-ascorbic acid yielded a flux of 0.29 ± 0.01 mg ∙ cm-2 ∙ h-1 in phosphate buffered saline (PBS, pH 7.4) and absorption of 87 ± 7 % of the applied dose after 8 h. Experiments with α-tocopherol showed no penetration in PBS with added bovine serum albumin (BSA), leading to the hypothesis that more hydrophobic membranes and/or receptor medium are needed for the study of lipophilic compounds. In addition, the release of benzoic acid from the amorphous mesoporous magnesium carbonate Upsalite® was investigated. The results showed significant release and penetration of benzoic acid from the solid matrix in both acetate buffer and PBS. The maximum flux was estimated to 6.61 ± 0.96 mg ∙ cm-2 ∙ h-1 in acetate buffer and 99 ± 9 % of the applied dose was absorbed after 3h. Tests of Upsalite with benzoic acid on hydrophobic silicone and Strat-M membranes showed no significant penetration, likely due to insufficient wetting of the sample. Pre-wetting of Strat-M membrane lead to penetration of benzoic acid into the membrane. Flux rates achieved on synthetic membranes are generally much higher compared to skin, which results in this thesis show. In conclusion, data for pure benzoic acid and L-ascorbic acid in the developed method using dialysis membranes showed reasonable agreement with literature. Penetration of benzoic acid is pH-dependent and may be either increased or decreased by choice of skin model or by using Upsalite as vehicle. Choosing a buffer pH below the pKa of the substance may enhance penetration. Introducing L-ascorbic acid in Upsalite could potentially increase the permeation, similar to that of benzoic acid.

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Βασιλακοπούλου, Αναστασία. "Μεσοπορώδη βιοενεργά υλικά". Thesis, 2013. http://hdl.handle.net/10889/7253.

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Στην παρούσα μεταπτυχιακή εργασία ειδίκευσης περιγράφεται η σύνθεση και ο χαρακτηρισμός νέων μεσοπορωδών βιοενεργών υλικών. Παρουσιάζονται οι συσχετιζόμενες με τα πορώδη/μεσοπορώδη υλικά έννοιες, οι ιδιότητες τους και διάφοροι τρόποι σύνθεσης τους. Εν συνεχεία, αναλύονται θέματα βιουλικών, δίνοντας έμφαση στις βιοϋάλους και τις ιδιότητες τους, και ειδικότερα στη βιονεργότητα, που αποτελεί την πιο χαρακτηριστική ιδιότητα αυτών, ενώ δίνεται έμφαση, επίσης στις διάφορες μεθόδους που χρησιμοποιούνται για την σύνθεση τους. Στην συνέχεια αναλύονται οι τεχνικές που χρησιμοποιήθηκαν για το χαρακτηρισμό των προαναφερθέντων υλικών καθώς και ο τρόπος λειτουργίας της κάθε τεχνικής. Επίσης, γίνεται αναφορά στα διαφορετικά χαρακτηριστικά των υλικών που μπορούν να μελετηθούν για κάθε τεχνική ξεχωριστά. Στο τελευταίο κεφάλαιο παρουσιάζεται αναλυτικά η διαδικασία διεξαγωγής των πειραμάτων, οι διάφοροι τρόποι σύνθεσης που χρησιμοποιήθηκαν, καθώς και σχολιασμός των αποτελεσμάτων. Τέλος, παρουσιάζονται τα συμπεράσματα που προέκυψαν από τα πειραματικά αποτελέσματα για την παρούσα μεταπτυχιακή εργασία. Επίσης γίνεται αναφορά και σε μελλοντικές κατευθύνσεις που περιλαμβάνουν την χρήση αυτών των υλικών σε σύνθετα υλικά για παλμική εναπόθεση με Laser και τεχνικές εναπόθεσης λεπτού υμενίου.
In this master thesis the synthesis and characterization of novel bioactive mesoporous materials is being reported. The notions related to porous/mesoporous materials, their properties and various synthetic methods are being discussed. Subsequently, the notion of “biomaterials” is further analyzed, focusing on bioglasses and their properties. The meaning of bioactivity is also analyzed as the most characteristic feature of bioglasses while various methods used for the synthesis of these are discussed. Following the techniques used to characterize these materials as well as the operating mode of each technique is discussed. In the last chapter, the experimental processes are reported as well as the results are being discussed. Finally, the conclusions of all the experiments and analysis are reported. Also, future directions include the usage of these materials in composite materials for laser ablation and thin film deposition techniques are mentioned.

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Części książek na temat "Mesoporous Materials -Bioactive Pharmaceuticals -"

Joyce, Paul, Hayley B. Schultz, Tahlia R. Meola, Ruba Almasri i Clive A. Prestidge. "Application of Spray Dried Encapsulated Bioactives in Pharmaceuticals". W Spray Drying Encapsulation of Bioactive Materials, 423–60. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780429355462-16.

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Gómez-Cerezo, N., D. Arcos i M. Vallet-Regí. "Mesoporous bioactive glasses for biomedical composites". W Materials for Biomedical Engineering, 355–91. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-818431-8.00011-8.

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Wu, Chengtie, Jiang Chang i Yin Xiao. "Mesoporous Bioactive Glasses for Drug Delivery and Bone Tissue Regeneration". W Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery, 1–24. CRC Press, 2013. http://dx.doi.org/10.1201/b13926-2.

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Bin Zafar Auniq, Reedwan, Namon Hirun i Upsorn Boonyang. "Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release". W Ceramic Materials [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95290.

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Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity test performed by soaking the 3DOM-MBGCs in simulated body fluid (SBF) at 37°C. The results indicated that, the 45S5 have the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4. Gentamicin drug was used to examine in vitro drug release properties in phosphate buffer solution (PBS). The amount of drug release was quantified through UV/Vis spectroscopy by using o-phthaldialdehyde reagent. S53P4 showed high drug loading content. The outcome of drug release in PBS showed that both S53P4 and 45S5 exhibited a slowly continuous gentamicin release. The resultant drug release profiles were fitted to the Peppas-Korsmeyer model to establish the predominant drug release mechanisms, which revealed that the kinetics of drug release from the glasses mostly dominated by Fickian diffusion mechanism.

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Sun, Jin, Yongsheng Li, Liang Li, Wenru Zhao, Lei Li, Jianhua Gao, Meiling Ruan i Jianlin Shi. "The synthesis and bioactivity in vitro of functionalized mesoporous bioactive glasses". W Zeolites and related materials: Trends, targets and challenges, Proceedings of the 4th International FEZA Conference, 313–16. Elsevier, 2008. http://dx.doi.org/10.1016/s0167-2991(08)80205-4.

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Zhu, Yufang. "Functional Mesoporous Silica Nanoparticles with a Core-Shell Structure for Controllable Drug Delivery". W Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery, 47–82. CRC Press, 2013. http://dx.doi.org/10.1201/b13926-4.

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C. Ngwuluka, Ndidi, Nedal Y. Abu-Thabit, Onyinye J. Uwaezuoke, Joan O. Erebor, Margaret O. Ilomuanya, Riham R. Mohamed, Soliman M. A. Soliman, Mahmoud H. Abu Elella i Noura A. A. Ebrahim. "Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques". W Nano- and Microencapsulation - Techniques and Applications [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94856.

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Encapsulation, specifically microencapsulation is an old technology with increasing applications in pharmaceutical, agrochemical, environmental, food, and cosmetic spaces. In the past two decades, the advancements in the field of nanotechnology opened the door for applying the encapsulation technology at the nanoscale level. Nanoencapsulation is highly utilized in designing effective drug delivery systems (DDSs) due to the fact that delivery of the encapsulated therapeutic/diagnostic agents to various sites in the human body depends on the size of the nanoparticles. Compared to microencapsulation, nanoencapsulation has superior performance which can improve bioavailability, increase drug solubility, delay or control drug release and enhance active/passive targeting of bioactive agents to the sites of action. Encapsulation, either micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, biologics, or bioactive drugs from natural sources as well as for diagnostics such as biomarkers. The outcome of any encapsulation process depends on the technique employed and the encapsulating material. This chapter discusses in details (1) various physical, mechanical, thermal, chemical, and physicochemical encapsulation techniques, (2) types and classifications of natural polymers (polysaccharides, proteins, and lipids) as safer, biocompatible and biodegradable encapsulating materials, and (3) the recent advances in using lipids for therapeutic and diagnostic applications. Polysaccharides and proteins are covered in the second part of this chapter.

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C. Ngwuluka, Ndidi, Nedal Y. Abu-Thabit, Onyinye J. Uwaezuoke, Joan O. Erebor, Margaret O. Ilomuanya, Riham R. Mohamed, Soliman M.A. Soliman, Mahmoud H. Abu Elella i Noura A.A. Ebrahim. "Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques". W Nano- and Microencapsulation - Techniques and Applications. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94856.

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Hanaei, Shirin B., i Yvonne Reinwald. "Application of Bioceramics to Cancer Therapy". W Applications of Nanomaterials in Medical Procedures and Treatments, 209–46. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815136951123040008.

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Despite the great medical developments, cancer remains the main cause of death amongst individuals under 85 years. Novel therapeutic approaches for cancer therapy are constantly being developed, and bioactive ceramics show great promise in this respect. Bioceramics contain inorganic components, which help in the repair, replacement, and regeneration of human cells; for that reason, their use is growing in scope. Bioceramics have a flexible nature and can be modified with biologically active substances for a particular treatment or improvement of tissue or organ functionality. Materials, including glass-ceramics and calcium phosphate, can be loaded with specific drugs, growth factors, peptides, and hormones in a particular fashion. Also, for the elimination of infections and inflammations after surgery, the surface of bioceramics can be modified, and antibiotics can be introduced to prevent bacterial biofilm formation. In the context of bone cancer diagnosis and treatment, mesoporous bioceramics have demonstrated excellent properties not only for being osteoinductive and osteoconductive but also for drug delivery, therefore, being rendered as a remarkable platform for the creation of bone tissue engineering scaffolds for the purpose of bone cancer treatment. Furthermore, the creation of ceramic magnetic nanoparticles as thermoseeds for hyperthermia exhibits promising development for cancer treatment. The conjugation of ceramic nanoparticles with therapeutic agents and heat treatment via different magnetic fields improve the efficacy of hyperthermia to the extent that it makes them an alternative to chemotherapy. This chapter discusses the therapeutic value of bioceramics.

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Streszczenia konferencji na temat "Mesoporous Materials -Bioactive Pharmaceuticals -"

Berechet, Mariana Daniela, Demetra Simion, Rodica Roxana Constantinescu, Maria Stanca i Cosmin Andrei Alexe. "Active Principles in Basil Essential Oil – Ocimum basilicum L. Cotton Linings with Antibacterial Properties". W The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.ii.3.

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Ocimum basilicum L. is an aromatic plant in the family Lamiaceae with bioactive properties used since ancient times in traditional medicine. The active ingredients of basil essential oil can be used in perfumes, pharmaceuticals, medicine, cosmetics or spices. In this study, the essential oil of basil was obtained by hydrodistillation in the Clevenger continuous extractor. It was characterized by GC-MS and 53 constituent compounds were identified. The majority compounds were highlighted: linalool, 64,569%, p-allyl anisol, 5,163%, Eucalyptol, 3,745%, α-Cadinene, 3,510%. Kovats indices were calculated and FT-IR analysis was performed to confirm the specific constituent compounds. The essential oil of basil was microbiologically analyzed against Escherichia coli (ATCC 10536) Gram-negative bacteria and against Staphylococcus aureus (ATCC 6538) Gram-positive bacteria by diffusometric working method. Antibacterial activity was determined by measuring the diameter of the inhibition zone around the samples. Samples of filter paper and cotton fabric were used to simulate shoe lining and bandages. Basil essential oil has resistance against the tested strains, observing the increase of the inhibition zone with the increase of the amount of essential oil used in treatments (20 μL, 30 μL, 50 μL). The results showed that Ocimum basilicum L. may be a good candidate as a plant-derived antibacterial agent for medical footwear, wound dressings and other medical applications.

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