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1

Merkert, Arvid [Verfasser]. "Untersuchungen zum Einsatz von Siliziumcarbid-Leistungstransistoren in Traktionsantriebsumrichtern / Arvid Merkert". Hannover, 2018. http://d-nb.info/1158670613/34.

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Merkert, Dennis [Verfasser], i Bernd [Akademischer Betreuer] Simeon. "Numerical Homogenization for Linear Elasticity in Translation Invariant Spaces / Dennis Merkert ; Betreuer: Bernd Simeon". Kaiserslautern : Technische Universität Kaiserslautern, 2018. http://d-nb.info/1163274607/34.

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Mokhele, Tshediso Andrew. "The application of DNA fingerprinting and marker-assisted backcross selection in breeding for sunflower high oleic acid content lines / by Tshediso Andrew Mokhele". Thesis, North-West University, 2013. http://hdl.handle.net/10394/9793.

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Sunflower (Helianthus annuus L.) high oleic acid content lines differ from conventional sunflower by an increase in oleic acid (C18:1) content of more than 60%. The current sunflower cultivars under production in South Africa are standard sunflower with high levels of linoleic acid (C18:2). The aim of this study was to improve the quality of oil produced by local sunflower germplasm with respect to oleic acid through employing a marker-assisted breeding technique to facilitate and speed up the recovery of the high oleic acid allele into the background of the recurrent parent genome. Eleven sunflower breeding genotypes with high and low oleic acid traits were obtained from the Agricultural Research Council-Grain Crops Institute (ARC-GCI) in Potchefstroom. The breeding genotypes were phenotypically characterised based on their oleic and linoleic acid levels using gas chromatography. Results demonstrated that the average mean of oleic and linoleic acid contents in high oleic acid genotypes were 72% and 17% respectively, while the average mean of oleic acid and linoleic acid contents in wild type lines were 33.5 % and 54 % respectively. These results indicated a perfect negative correlation between the amount of oleic and linoleic acids possessed in high and low oleic acid genotypes (R2 = -99.16%). Sequence characterised amplified region (SCAR) markers were tested to ascertain if any of the ten available dominant FAD2-1 markers was segregating with the high oleic acid allele. Four dominant SCAR markers (FAD2-1F4/R1; FAD2-1F4/R2; FAD2-1F13/R1; FAD2-1F14/R2) were strongly associated with the high oleic acid trait (P< 0.001). With regard to the inheritance of the high oleic acid trait, 143 plants of the F2 segregating population derived from a cross between the high oleic acid parent (AP901-95-3-4-1) and low oleic acid parent (H55-9-2-1-1) were genotyped with the four SCAR markers to determine the genetic state concerning the high oleic acid gene (Ol). Results from a Chi square analysis of the observed frequencies of each dominant FAD2-1 marker locus in 143 F2 individuals indicated that the deviation from the expected ratio of 3:1 (high to low oleic acid) was not statistically significant (P< 0.95) from the observed segregation ratio. These results were consistent with the previous finding that an incomplete dominant gene governs sunflower high oleic acid. A multiplex assay of 78 Simple sequence repeat (SSR) markers was optimised and evaluated on 143 plants of the F2 population to determine suitable SSR markers that can be used in a marker-assisted background selection. Only 14 markers were suitable for marker-assisted background selection based on their high polymorphic information content, allele frequency and maximum allele numbers. In conclusion, this study demonstrated the potential of using SSR and SCAR marker systems as a breeding tool to characterise and speed up the selection process in marker-assisted backcross breeding.
Thesis (MSc (Botany))--North-West University, Potchefstroom Campus, 2013.
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4

Merkert, Wolfgang [Verfasser]. "Die NCB-DF-Platte : Anwendungen und Ergebnisse der ersten 50 Implantationen an der Universität Ulm / Wolfgang Merkert". Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1027536980/34.

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5

Merker, Michael [Verfasser], i M. [Akademischer Betreuer] Siegel. "Superconducting integrated THz receiver / Michael Merker ; Betreuer: M. Siegel". Karlsruhe : KIT Scientific Publishing, 2019. http://d-nb.info/1201481694/34.

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6

Merkert, Lennart [Verfasser], Sören [Akademischer Betreuer] Hohmann i Hendrik [Akademischer Betreuer] Lens. "Optimal Scheduling of Combined Heat and Power Generation Considering Heating Grid Dynamics / Lennart Merkert ; Sören Hohmann, Hendrik Lens". Karlsruhe : KIT Scientific Publishing, 2021. http://d-nb.info/1228537313/34.

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7

Eksteen, Aletta. "Ontwikkeling van molekulere merkers vir wilde-spesie-verhaalde weerstandsgeenkomplekse van gewone koring". Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2087.

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Thesis (MSc (Genetics))--University of Stellenbosch, 2009.
Worldwide, the rust diseases cause significant annual wheat yield losses (Wallwork 1992; Chrispeels & Sadava 1994). The utilization of host plant resistance to reduce such losses is of great importance particularly because biological control avoids the negative environmental impact of agricultural chemicals (Dedryver et al. 1996). The wild relatives of wheat are a ready source of genes for resistance to disease and insect pests. A large degree of gene synteny still exists among wheat and its wild relatives (Newbury & Paterson 2003). It is therefore possible to transfer a chromosome segment containing useful genes to a homologous region in the recipient genome without serious disruption of genetic information. Special cytogenetic techniques are employed to transfer genes from the wild relatives to the wheat genomes (Knott 1989). Unfortunately the transfer of useful genes may be accompanied by the simultaneous transfer of undesirable genes or redundant species chromatin which has to be mapped and removed (Feuillet et al. 2007). DNA markers are extremely useful for the characterisation and shortening of introgressed regions containing genes of interest (Ranade et al. 2001), and may also be used for marker aided selection of the resistance when the genes are employed commercially. Eight wheat lines containing translocations/introgressions of wild species-derived resistance genes were developed by the Department of Genetics (SU). These lines are presently being characterized and mapped and attempts are also being made to shorten the respective translocations. This study aimed to find DNA markers for the various translocations and to convert these into more reliable SCAR markers that can be used in continued attempts to characterize and improve the respective resistance sources. A total of 260 RAPD and 21 RGAP primers were used to screen the eight translocations and, with the exception of Lr19, it was possible to identify polymorpic bands associated with each translocation. However, it was not possible to convert all of these into more reliable SCAR markers. The primary reason for this was the low repeatability of most of the bands. Certain marker fragments turned out to be repeatable but could not be converted successfully. Some of the latter can, however, be used directly (in RAPD or RGAP reactions) as markers. The Lr19 translocation used in the study (Lr19-149-299) is a significantly reduced version of the original translocation and failure to identify polymorphisms associated with it can probably be ascribed to its small size. The following numbers of markers (direct and converted into SCARs) were Worldwide, the rust diseases cause significant annual wheat yield losses (Wallwork 1992; Chrispeels & Sadava 1994). The utilization of host plant resistance to reduce such losses is of great importance particularly because biological control avoids the negative environmental impact of agricultural chemicals (Dedryver et al. 1996). The wild relatives of wheat are a ready source of genes for resistance to disease and insect pests. A large degree of gene synteny still exists among wheat and its wild relatives (Newbury & Paterson 2003). It is therefore possible to transfer a chromosome segment containing useful genes to a homologous region in the recipient genome without serious disruption of genetic information. Special cytogenetic techniques are employed to transfer genes from the wild relatives to the wheat genomes (Knott 1989). Unfortunately the transfer of useful genes may be accompanied by the simultaneous transfer of undesirable genes or redundant species chromatin which has to be mapped and removed (Feuillet et al. 2007). DNA markers are extremely useful for the characterisation and shortening of introgressed regions containing genes of interest (Ranade et al. 2001), and may also be used for marker aided selection of the resistance when the genes are employed commercially. Eight wheat lines containing translocations/introgressions of wild species-derived resistance genes were developed by the Department of Genetics (SU). These lines are presently being characterized and mapped and attempts are also being made to shorten the respective translocations. This study aimed to find DNA markers for the various translocations and to convert these into more reliable SCAR markers that can be used in continued attempts to characterize and improve the respective resistance sources. A total of 260 RAPD and 21 RGAP primers were used to screen the eight translocations and, with the exception of Lr19, it was possible to identify polymorpic bands associated with each translocation. However, it was not possible to convert all of these into more reliable SCAR markers. The primary reason for this was the low repeatability of most of the bands. Certain marker fragments turned out to be repeatable but could not be converted successfully. Some of the latter can, however, be used directly (in RAPD or RGAP reactions) as markers. The Lr19 translocation used in the study (Lr19-149-299) is a significantly reduced version of the original translocation and failure to identify polymorphisms associated with it can probably be ascribed to its small size. The following numbers of markers (direct and converted into SCARs) were v identified: S8-introgression (Triticum dicoccoides) = one RAPD and two SCARs; S13-translocation (Aegilops speltoides) = four RAPDs, three RGAPs and five SCARs; S15-translocation (Ae. peregrina) = one RAPD and two SCARs; S20-translocation (Ae. neglecta) = two RAPDs, two RGAPs and one SCAR. The markers are already being employed in current projects aiming to map and shorten these translocations. Some of the markers can be combined in multiplex reactions for more effective mass screening. No repeatable markers could be identified for the four remaining translocations (S12 from Ae. sharonensis; S14 from Ae. kotschyi; Smac from Ae. biuncialis and Lr19-149-299 from Thinopyrum ponticum).
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8

Merker, Oliver [Verfasser]. "Experimentelle und theoretische Untersuchung eines PCM-Sonnenschutz-Verbundsystems / Oliver Merker". Aachen : Shaker, 2003. http://d-nb.info/1181601576/34.

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9

Merker, Thomas [Verfasser]. "Polarisationsmodendispersion in hochratigen faseroptischen Übertragungssystemen : Modellierung, Auswirkung und Kompensation / Thomas Merker". Aachen : Shaker, 2003. http://d-nb.info/1179021002/34.

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10

Ramírez, Calle Olga [Verfasser], Barbara [Akademischer Betreuer] Merker i Ursula [Akademischer Betreuer] Wolf. "Konsequenzen der postempiristischen Sprachphilosophie für die metaethische Diskussion : moralischer Realismus und die Frage nach der Begründung der Moral / Olga Ramírez Calle. Gutachter: Barbara Merker ; Ursula Wolf. Betreuer: Barbara Merker". Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2011. http://d-nb.info/1044274603/34.

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11

Merkert, Maximilian [Verfasser], Frauke [Gutachter] Liers, Rüdiger [Gutachter] Schultz i Christoph [Gutachter] Helmberg. "Solving Mixed-Integer Linear and Nonlinear Network Optimization Problems by Local Reformulations and Relaxations / Maximilian Merkert ; Gutachter: Frauke Liers, Rüdiger Schultz, Christoph Helmberg". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1154308707/34.

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Merker, Claire [Verfasser], i Felix [Akademischer Betreuer] Ament. "Estimating the Uncertainty of Areal Precipitation using Data Assimilation / Claire Merker ; Betreuer: Felix Ament". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2017. http://d-nb.info/1144485363/34.

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13

Merker, Lukas Verfasser], T. A. [Akademischer Betreuer] Costi, Volker [Akademischer Betreuer] [Meden i Ralf [Akademischer Betreuer] Bulla. "Thermoelectric transport through quantum dots / Lukas Merker ; T. A. Costi, Volker Meden, Ralf Bulla". Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1133078958/34.

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14

Merker, Matthias [Verfasser]. "Globale Populationsstruktur und Evolution von Mycobacterium tuberculosis Komplex-Stämmen des Beijing-Genotyps / Matthias Merker". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2015. http://d-nb.info/1067211853/34.

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15

Merker, Lukas [Verfasser], T. A. Akademischer Betreuer] Costi, Volker [Akademischer Betreuer] [Meden i Ralf [Akademischer Betreuer] Bulla. "Thermoelectric transport through quantum dots / Lukas Merker ; T. A. Costi, Volker Meden, Ralf Bulla". Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1133078958/34.

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16

Merker, Andreas [Verfasser], Martin [Akademischer Betreuer] Hermann, Andre [Akademischer Betreuer] Seyfarth i Gerhard [Akademischer Betreuer] Zumbusch. "Numerical bifurcation analysis of the asymmetric spring-mass model / Andreas Merker. Gutachter: Martin Hermann ; Andre Seyfarth ; Gerhard Zumbusch". Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1058858025/34.

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17

Merker, Sabine [Verfasser], i Frank P. [Akademischer Betreuer] Nothdurft. "Frakturverhalten von implantatgetragenen und implantatzahngetragenen vollkeramischen Seitenzahnbrücken unter Verwendung von Zirkoniumoxid-Abutments / Sabine Merker. Betreuer: Frank P. Nothdurft". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051434637/34.

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18

Havlicek, Juliane [Verfasser], Matthias [Akademischer Betreuer] Merker i Jeanette [Akademischer Betreuer] Erdmann. "Molekulare Nachweissysteme für Antibiotika-Resistenz vermittelnde Mutationen bei Mycobacterium tuberculosis / Juliane Havlicek ; Akademische Betreuer: Matthias Merker, Jeanette Erdmann". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1236780191/34.

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19

Kammerstätter, Stefan [Verfasser], Thomas [Akademischer Betreuer] Sattelmayer i Günther P. [Akademischer Betreuer] Merker. "Verbrennungsablauf und Schadstoffbildung in Erdgas-Großmotoren mit Vorkammerzündung / Stefan Kammerstätter. Gutachter: Günther P. Merker ; Thomas Sattelmayer. Betreuer: Thomas Sattelmayer". München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/103151516X/34.

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Kammerstätter, Stefan Verfasser], Thomas [Akademischer Betreuer] Sattelmayer i Günter P. [Akademischer Betreuer] [Merker. "Verbrennungsablauf und Schadstoffbildung in Erdgas-Großmotoren mit Vorkammerzündung / Stefan Kammerstätter. Gutachter: Günther P. Merker ; Thomas Sattelmayer. Betreuer: Thomas Sattelmayer". München : Universitätsbibliothek der TU München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20121122-1111862-1-6.

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21

Kamfer, Fanie. "Characterising tuberculosis treatment success and failure using metabolomics / Fanie Kamfer". Thesis, North-West University, 2013. http://hdl.handle.net/10394/10203.

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Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization (WHO). Currently, South Africa ranks third on the 2011 list of 22 high-burden TB countries in the world and it was estimated that each active-TB person could potentially infect 10–15 people annually. The WHO additionally reported that in the year 2009, 87% of all TB patients worldwide were successfully treated, with a treatment success rate of 74% reported for South Africa. Despite this however, non-adherence to anti-TB treatment is still a major issue, due to it resulting in a global increased prevalence of drug resistant TB and subsequently TB treatment failure. Treatment failure is thought to be caused by a number of factors, however, it still remains largely misunderstood. One aspect of this, that isn't clearly addressed in the literature, is the underlying variation in each patient, resulting in his/her varying reaction to the drug regimen, and hence it’s varying efficacy from one patient to the next. Furthermore, little is known about the underlying variation of the host to the primary TB infection or response to the TB disease state, and how some patients have more effective mechanisms for eliminating the infection, or recovering from the disease. Considering this, a metabolomics research study using GC×GC-TOFMS was conducted, in order to identify potential metabolite markers which may be used to better characterise the underlining mechanisms associated with poor treatment outcomes (treatment failure). The first aim was to evaluate the accuracy and efficiency of the methodology used, as well as to determine the capability and accuracy of the analyst to perform these methods. In order to evaluate the GCxGC-TOFMS analytical repeatability, one QC sample was extracted and injected repeatedly (6 times) onto the GC×GC-TOFMS. Similarly, the analyst's repeatability for performing the organic acid extraction and analyses was also determined, using 10 identical QC samples, which were extracted and injected separately. CV values were subsequently calculated from the collected and processed data as a measure of this. Of all the compounds detected from the 6 QC sample repeats used for GCxGC-TOFMS repeatability, 95.59% fell below a 50% CV value, and 93,7% of all the compounds analysed for analyst repeatability had a CV < 50. Subsequently, using the above metabolomics approach, in addition to a wide variety of univariate and multivariate statistical methods, two patient outcome groups were compared. A sample group cured from TB after 6 months of treatment was compared vs a sample group where treatment failed after the 6 month period. Using urine collected from these two patient groups at various time points, the following metabolomics comparisons where made: 1) at time of diagnosis, before any anti-TB treatment was administrated, 2) during the course of treatment, in order to determine any variance in these groups due to a varying response to the anti-TB drugs, 3) over the duration of the entire 6 months treatment regimen, in order to determine if differences exist between the two groups over time. A clear natural differentiation between the cured and failed outcome groups were obtained at time of diagnosis, and a total of 39 metabolites markers were subsequently identified. These metabolites were classified according to their various origins, and included (1) those associated with the presence of M. tuberculosis bacteria, (2) those resulting from an altered host metabolism due to the TB infection, and (3) metabolites of various exogenous origins. The detailed interpretation of these metabolites suggests that a possible underlying RCD or some sort of mitochondrial dysfunction may be present in the treatment failure group, which may also be induced through an external stimulus, such as alcohol consumption. We hypothesise that this may possibly result in a far greater severity to M. tuberculosis infection in this group, subsequently causing a reduced capacity for a successful treatment outcome, also considering the critical role of the mitochondria in the metabolism of anti-TB drugs. Furthermore, 20 metabolite markers were identified when comparing the two outcome groups during the treatment phase of this metabolomics investigation. A vast majority of these 20 metabolites were also identified as markers for time 0 (time of diagnosis). Additionally, metabolites associated with anti-TB drug induced side effects, were also found to be comparatively increased in the treatment failure group, indicative of more pronounced liver damage, accompanied by metabolites characteristic of a MADD metabolite profile, due to a deficient electron transport flavoprotein, confirming previous experiments done in rats. These side effects have also previously been implicated as a major contributor of poor treatment compliance, and ultimately treatment failure. Lastly, 35 metabolite markers were identified by time dependent statistical analysis and represented those metabolites best describing the variation between the treatment outcome groups over the entire study duration (from diagnosis, to week 26). This time dependent statistical analysis identified markers, using an alternative statistical approach, and confirmed previous findings and added in a better characterisation of treatment failure. Considering the above, we successfully applied a metabolomics approach for identifying metabolites which could ultimately aid in the prediction and monitoring of treatment outcomes. This additionally led to a better understanding and or characterisation of the phenomenon known as treatment failure, as well as the underlying mechanisms related to this occurrence.
MSc (Biochemistry), North-West University, Potchefstroom Campus, 2013
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22

Merker, Ludwig [Verfasser]. "Engagement, Studienerfolg und Berufserfolg : eine Untersuchung über Zusammenhänge im Lebenslauf von Absolventen der Betriebswirtschaftslehre an der Universität Bayreuth / vorgelegt von Ludwig Merker". [Bayreuth] : [L. Merker], 2009. http://d-nb.info/997381299/34.

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23

Michael, Ben [Verfasser], Eckhard [Akademischer Betreuer] Liebscher, Jochen [Akademischer Betreuer] Merker i Heidi [Gutachter] Krömker. "E-Assessment : automatische Generierung parametrisierter Aufgaben für mathematische Assessments in E-Learning-Systemen / Ben Michael ; Gutachter: Heidi Krömker ; Eckhard Liebscher, Jochen Merker". Ilmenau : TU Ilmenau, 2021. http://d-nb.info/1241044953/34.

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Merker, Katharina [Verfasser], i Götz [Gutachter] Grigoleit. "Analyse zur Kreuzreaktivität von CMV IE-1 VLEETSVML (316-324) spezifischen T-Zellen gegen hämatologische Neoplasien in gesunden Spendern / Katharina Merker ; Gutachter: Götz Grigoleit". Würzburg : Universität Würzburg, 2019. http://d-nb.info/1180286707/34.

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Merker, Sören [Verfasser], Klaus-Peter [Gutachter] Lesch i Erhard [Gutachter] Wischmeyer. "Genome-wide screenings in attention-deficit/hyperactivity disorder (ADHD): investigation of novel candidate genes SLC2A3 and LPHN3 / Sören Merker. Gutachter: Klaus-Peter Lesch ; Erhard Wischmeyer". Würzburg : Universität Würzburg, 2014. http://d-nb.info/110974997X/34.

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Merkert, Christine [Verfasser], i Gereon [Akademischer Betreuer] Niedner-Schatteburg. "Metal cluster aggregates of the composition Fen+/, Con+/-, Nin+/- and [ConMm]+/- (M: Au, Rh and Pt) as model systems for catalytic C-H activation and structural determination of ionic dicarboxylic acids as model system for intramolecular hydrogen bonding / Christine Merkert. Betreuer: Gereon Niedner-Schatteburg". Kaiserslautern : Technische Universität Kaiserslautern, 2014. http://d-nb.info/1051310377/34.

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Merker, Philine [Verfasser], Wolfgang [Akademischer Betreuer] Wuttke, Michael [Akademischer Betreuer] Hüfner i Martin [Akademischer Betreuer] Oppermann. "Wie gefährdet sind wir durch endokrine Disruptoren? : Effekt von Daidzein und 4-MBC im Vergleich mit 17β-Östradiol auf den Uterus der ovarektomierten Ratte / Philine Merker. Gutachter: Wolfgang Wuttke ; Michael Hüfner ; Martin Oppermann. Betreuer: Wolfgang Wuttke". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044736437/34.

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Kříž, Radim. "Uniform Marker Field na válci". Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-236201.

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This work presents a new extension for Uniform Marker Field, which is able to detect UMF on the cylinder. First part of the text deals with Augmented reality and focuses on systems using markers. It discusses the actual state-of-the-art systems and its possibilities. After that it focuses more deeply on the marker system Uniform marker field and its grayscale variants. Next part of the work describes properties of the cylinder projected in real space. Important properties for detecting are discussed in detail. Then the proposal and description of detection algorithm is presented. Implementation of algorithm is tested and evaluated on the very end of this thesis.
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Fourie, Annamarie. "Korpuslinguistiese ondersoek na pragmatiese merkers in Omgangsafrikaans". Diss., 2020. http://hdl.handle.net/10500/26742.

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Text in Afrikaans with summaries in Afrikaans, English and Tshwana
Includes bibliographical references (leaves 183-193)
Pragmatiese merkers in Omgangsafrikaans dien as belangrike kontekstualiseringswenke. Dit rig gespreksgenote in terme van uitingrelevansie en stel die spreker in staat om, op bondige wyse, ’n houding teenoor die proposisie van die uiting te openbaar. Dit dra ook by tot die gesprekstruktuur. Die sistematiese ondersoek na pragmatiese merkers volg ’n eklektiese benadering: die relevansieteorie, grammatikalisasieteorie, diskoersanalise, sosiopragmatiek en korpuslinguistiek word ingespan om die verskynsel te bestudeer en te verklaar. Die pragmatiese merkers “rêrig/regtig”, “oukei”, “soos”, “hoor” en “weet” is bestudeer aan die hand van die Pretoriakorpus van Omgangsafrikaans (PO) vanweë hul hoë gebruiksfrekwensie in die korpus. ’n Vergelyking van die gebruiksfrekwensies van hierdie pragmatiese merkers onder verskillende groeperinge van sprekers toon aan dat jong, volwasse en bejaarde mans en vroue dit verskillend gebruik. Die onderskeie funksies bied voorts leidrade waardeur die grammatikalisasie van pragmatiese merkers nagespeur kan word. Dit wil voorkom asof jong vroulike sprekers die voortou neem in die gebruik en ontwikkeling van pragmatiese merkers teenoor jong manlike sprekers. Die studie het verder bevind dat veral volwasse vroulike sprekers aktief bydra tot die ontwikkeling van hierdie pragmatiese merkers.
Pragmatic markers in interactional Afrikaans serve as important contextualising cues. They guide interlocutors as to the relevance of utterances and equip the speaker to signal an attitude towards the proposition of the utterance in a succinct way. They also contribute to the conversation structure. The systematic investigation of pragmatic markers follows an eclectic approach: relevance theory, grammaticalisation theory, discourse analysis, sociopragmatics and corpus linguistics are engaged in order to study and explain the phenomenon. The pragmatic markers “rêrig/regtig”, “oukei”, “soos”, “hoor” en “weet” are studied on the basis of the Pretoriakorpus van Omgangsafrikaans (PO) owing to their high frequency in the corpus. A comparison of the usage frequencies of these pragmatic markers among various groups of speakers indicates that young, adult and elderly men and women use them differently. The respective functions offer clues by which the grammaticalisation of pragmatic markers may be traced. It appears that young female speakers take the lead in the use and development of pragmatic markers compared to young male speakers. The study further found that especially adult female speakers contribute actively to the development of these pragmatic markers.
Matshwao a puo mo puong ya kgolagano ya Afrikaans a dira jaaka matshwao a botlhokwa a bokao. A kaela babui ka bomaleba jwa dipuo le go thusa sebui go bontsha maikutlo malebana le polelo e e tshitshinngwang ka boripana. Gape a tshwaela mo sebopegong sa puisano. Tshekatsheko e e rulaganeng ya matshwao a puo e ne e dirisa mekgwa e e farologaneng: tiori ya bomaleba, tiori ya tiriso ya thutapuo, tshekatsheko ya puisano, matshwao a puoloago le thuto ya dipuo e e lebelelang dikwalo tse di gona (corpus linguistics) di dirisitswe go batlisisa le go tlhalosa dikgakgamatso tseo. Matshwao a puo a “rêrig/regtig”, “oukei”, “soos”, “hoor” le “weet” a batlisisitswe go lebeletswe Pretoriakorpus van Omgangsafrikaans (PO) ka ntlha ya go nna teng ga ona thata mo dikwalong. Tshwantshanyo ya seelo sa tiriso ya matshwao ano a puo magareng ga ditlhopha tsa dibui e supa gore bašwa, bagolo le bagodi ba banna le basadi ba a dirisa ka ditsela tse di farologaneng. Ditiro tse di rileng di bontsha disupi tse ka tsona go ka latedisiwang tiriso ya thutapuo ya matshwao a puo. Go bonala fa dibui tsa bašwa ba basadi di eteletse pele mo tirisong le kgodisong ya matshwao a puo fa di ntshwantshanngwa le dibui tsa banna. Thutopatlisiso e fitlheletse gape gore dibui tsa bagolo ba basadi bogolosegolo di tshwaela ka botlhaga mo kgodisong ya matshwao ano a puo.
Afrikaans and Theory of Literature
M.A. (Afrikaans)
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Merkert, Gerhard [Verfasser]. "Anwendung und Weiterentwicklung von schädigungsmechanischen Ansätzen zur Simulation des Versagensverhaltens von Thermoschockproben / vorgelegt von Gerhard Merkert". 2002. http://d-nb.info/965669955/34.

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Merker, Sandra [Verfasser]. "Reaktionen des Endodonts auf nichtkariöse Zahnhartsubstanzverluste : eine Histomorphologische Studie / von Sandra Merker". 2004. http://d-nb.info/973132973/34.

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Merker, Jochen [Verfasser]. "Analysis of natural function spaces and dynamics on noncompact manifolds under symmetry / vorgelegt von Jochen Merker". 2005. http://d-nb.info/976347660/34.

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Merker, Stefan [Verfasser]. "Vom Aussterben bedroht oder anpassungsfähig? : der Koboldmaki Tarsius dianae in den Regenwäldern Sulawesis / vorgelegt von Stefan Merker". 2003. http://d-nb.info/968493742/34.

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Eksteen, Philna. "The association between fibrinolysis markers and body composition in black adults in the North West Province of South Africa / Philna Eksteen". Thesis, 2014. http://hdl.handle.net/10394/13322.

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INTRODUCTION - Plasminogen activator inhibitor type-1 (PAI-1) has a known relationship with obesity and more specifically with central obesity. Traditionally the physiological contribution of PAI-1 is seen as an indicator of fibrinolysis with increased PAI-1 levels contributing to decreased fibrinolysis. In more recent years, assays have been developed that not only uses proxy markers, such as PA-1, which is considered to be representative of fibrinolysis , but global assays that report on the global fibrinolytic potential of an individual, often reported as clot lysis time (CLT). Investigations into the relationship of CLT with obesity are scarce. Preliminary evidence shows that the relationship of CLT with obesity may differ from that of PAI-1 with obesity although in depth investigations in this regard are lacking. Therefore, the aim of this study was to investigate the association between fibrinolysis markers (PAI-1act and CLT) and various markers of body composition in the South African Prospective Urban and Rural Epidemiology (PURE) data collected during 2010. METHODS - Data collected in the PURE study in 2010 were cross-sectionally analysed. The participants (n = 1288) were apparently healthy black South-African men and women 35 years and older, residing in urban and rural settlements in the North-West Province. Experimental methods included anthropometric measurements such as height, weight, hip circumference, waist circumference, skinfolds (triceps, chest, abdominal, thigh and supra iliac skinfolds) and body composition measurements by means of air-displacement plethysmography and biolelectrical impedance analysis. Laboratory analysis of fibrinolysis markers, PAI-1act and CLT were also performed. MAIN FINDINGS - In men, similarities were seen regarding the relationship between PAI-1act and body composition markers and the relationships observed between CLT and body composition markers. In contrast, in the women more and stronger associations were observed between CLT and body composition markers compared to that observed between PAI-1act and body composition markers. CLT showed a linear relationship with body composition markers where PAI-1act levels plateaued at higher body composition categories. Possible reasons for the observed differences may be related to differences in adipose tissue distribution and sequence of accumulation between men and women. PAI-1 is associated with visceral adipose tissue (VAT) where high amounts of stromal cells are found. In men preferential accumulation of VAT may explain similarities in the relationship of PAI-1act with body composition and that of CLT with body composition. Proportionally less VAT, but more subcutaneous adipose tissue in women may explain the observed increase in CLT compared to PAI-1act levels that plateaued over body composition tertiles and categories. CONCLUSION - PAI-1act has a stronger association with central obesity while CLT has a stronger association with total body fat. In women PAI-1act and CLT showed different associations with body composition markers, whereas associations of PAI-1act and CLT with body composition were similar in men. PAI-1act is strongly influenced by type of body fat accumulation whereas CLT is associated with obesity independent of type and sequence of body fact accumulation. Significant associations observed between CLT and body composition variables are, therefore, at least in part, independent of PAI-1act. Additional factors such as, thrombin activatable fibrinolysis inhibitor (TAFI), α-2-antiplasmin, plasminogen, prothrombin and fibrin clot structure that influence CLT and are also related to obesity may additionally contribute to the link between CLT and obesity.
MSc (Dietetics), North-West University, Potchefstroom Campus, 2014
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Mashele, Nyiko. "Depressive symptoms and cardiometabolic health in urban black Africans : the SABPA study / Nyiko Mashele". Thesis, 2014. http://hdl.handle.net/10394/11842.

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Motivation - Depression is a mental disorder that has been associated with cardiovascular morbidity and mortality in the Western world. Cardiometablic mechanisms have been implicated as possible intermediating factors in the relationship between depressive symptoms and cardiovascular disease; however this has not yet been determined in black Africans (hereafter referred to as Africans). Aim - The overarching aim of this study was to investigate the relationship between depressive symptoms and cardiometabolic risk. We therefore aimed to assess cardiometabolic function, neuroendocrine responses, inflammatory and haemostatic markers in Africans with depressive symptoms compared to those without symptoms of depression. Methodology - Manuscripts presented in Chapter 2, 3 and 4 utilised data from the cross-sectional, target population multi-disciplinary “Sympathetic activity and Ambulatory Blood Pressure in Africans” (SABPA) study. The participants comprised of 200 African teachers from the Dr Kenneth Kaunda District in North-West province, South Africa. As cardiovascular disease is compromised by a positive HIV status, 19 participants were excluded from further statistical analysis. Stratification was based on the Patient Health Questionnaire 9-item (PHQ-9), which has been validated in a sub-Saharan African setting. PHQ-9 scores > 10 were used to classify participants as having signs of depressive symptoms. Subjects were further stratified by gender (Manuscript 1 and 3) and cortisol responses (Manuscript 2). Cardiometabolic health measures included 24-hour blood pressure, metabolic syndrome markers, neuroendocrine markers [cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG)], left ventricular hypertrophy (LVH),inflammatory and haemostatic markers (fibrinogen, C-reactive protein, plasminogen activator inhibitor-1 and D-dimer). Resting 12-lead ECG Cornell Product-Left ventricular hypertrophy (CP-LVH) was measured as a marker of target end-organ damage and cardiovascular dysfunction (Manuscript 1 and 2). Means and prevalence were computed through t-test and Chi-square analysis respectively. Significant differences of mean cardiometabolic measures between depressive symptom status groups were also determined by analysis of covariance (adjusted for traditional cardiovascular risk factors and additional factors as specific per manuscript). Multivariate analysis was used to demonstrate associations between left ventricular hypertrophy (LVH) and cardiometabolic markers in Africans with depressive symptoms (Manuscript 1 and 2) and a logistic regression analysis were performed to examine the association between depressive symptoms and inflammatory/haemostatic factors (Manuscript 3). All subjects who participated gave informed consent, the study was approved by the Ethics Committee of North-West University (NWU-0003607S6), in accordance with the principles outlined by the World Medical Association Declaration of Helsinki of 1975 (revised 2008). Results and conclusions of the individual manuscripts - The aim of the study was to investigate the associations between depressive symptoms and cardiometabolic function including cardiovascular dysfunction. Markers of cardiometabolic function assessed were 24 hour blood pressure measurements, metabolic syndrome markers, neuroendocrine markers [cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG)], inflammatory and haemostatic variables (fibrinogen, C-reactive protein, plasminogen activator inhibitor-1 and D-dimer). Manuscript 1, focused on LVH as a marker of cardiovascular dysfunction and metabolic syndrome components as markers of cardiometabolic function. The aim of the study was to assess the associations between LVH and metabolic syndrome (MetS) risk markers in participants with and without depressive symptoms. Results revealed that in African men with depressive symptoms the most significant determinants of LVH were systolic blood pressure (SBP) and the percentage glycosylated haemoglobin (HbA1c). While in African women (with depressive symptoms), this association was determined by low high-density lipoprotein (HDL-cholesterol). The study concluded that in black African men, independent of depressive symptoms, cardiometabolic factors (namely SBP and HbA1c) may be the driving significant factors in the development of cardiovascular diseases. Furthermore, the data showed that depressive symptoms in African women were associated with a measure of target end organ damage, and that this association was driven by a metabolic factor. Manuscript 2, the aim of this manuscript was to examine the relationship between depressive symptoms, neuroendocrine responses [with cortisol and 3-methoxy-phenylglycol (MHPG) as markers] and cardiovascular risk, i.e. LVH. The results revealed that Africans with depressive symptoms demonstrated blunted cortisol and MHPG levels in response to acute mental stress, in comparison to those without symptoms of depression. Additionally, these low cortisol and blunted MHPG responses were associated with LVH in this ethnic group. The conclusion for this manuscript was that, blunted neuroendocrine responses linked depressive symptoms and ECG left ventricular hypertrophy in Africans. When coupled to their hypertensive status, these vasoconstrictive responses (cortisol and MHPG) may underpin the increased long-term depression and vascular disease risk in urban Africans. Manuscript 3, the aim of this manuscript was to investigate the relationship between depressive symptoms and inflammatory/haemostatic markers in a cohort of urban-dwelling black African men and women. Our data demonstrated hypercoagulation vulnerability in African men with depressive symptoms. The African men with signs of depression displayed higher plasminogen activator inhibitor (PAI-1) levels and marginally elevated D-dimer levels. It was concluded that hypercoagulation may partially be the mediating factor between depressive symptoms and cardiovascular risk in African men; a situation that may be exacerbated by hyperkinetic blood pressure. In conclusion, through the assessement of cardiometabolic function and neuroendocrine responses, it seems that Africans withdepressive symptoms are at great risk for cardiovascular related morbidity and mortality, this was particulary evident in the African men (Manuscript 1 and 3). Additionally, it appears that blunted neuroendocrine responses and hypercoagulation could be seen as possible cardiovascular risk markers in Africans with depressive symptoms.
PhD (Physiology), North-West University, Potchefstroom Campus, 2014
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