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Morgan, Vera Anne. "Intellectual disability co-occurring with schizophrenia and other psychiatric illness : epidemiology, risk factors and outcome". University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0209.
Pełny tekst źródłaNowak, Lisa Rebecca. "Philosophical perspectives on the stigma of mental illness". Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/13193.
Pełny tekst źródłaYee, Mean-Fong. "Dental Implications For The Patient With Mental Illness". Thesis, The University of Sydney, 1991. http://hdl.handle.net/2123/4960.
Pełny tekst źródłaCheung, Po-tin Erik, i 張步田. "Cultural influences on attitudes towards mental illness in Asia". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B26813749.
Pełny tekst źródłaLim, Jeong-Eun. "Regulatory genetic variants in mental illness focus on serotonin-related genes /". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1196198735.
Pełny tekst źródłaWilliams, William Paul. "Aspects of a psychiatric therapeutic milieu". Thesis, University of East London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361850.
Pełny tekst źródłaLong, Vicky. "Changing public representations of mental illness in Britain, 1870-1970". Thesis, University of Warwick, 2004. http://wrap.warwick.ac.uk/1217/.
Pełny tekst źródłaFincher, Cynthia Ellen. "Mental Status, Intellectual, and Mood States Associated with Environmental Illness Patients". Thesis, North Texas State University, 1991. https://digital.library.unt.edu/ark:/67531/metadc500843/.
Pełny tekst źródłaJenkinson, Crispin. "Social and psychological factors affecting the impact of painful chronic illness upon mental health". Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:2c6e33c7-4931-435c-bd60-d3958866087a.
Pełny tekst źródłaSun, Qi. "Assessing Social Determinants of Severe Mental Illness in High-Risk Groups". Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc500085/.
Pełny tekst źródłaDegenhardt, Louisa Psychology Faculty of Science UNSW. "Comorbidity between substance use and mental health in Australia: Relationships of alcohol, tobacco and cannabis use with other substance use and mental disorders". Awarded by:University of New South Wales. School of Psychology, 2001. http://handle.unsw.edu.au/1959.4/18247.
Pełny tekst źródłaBreen, Alison. "Experience of mental illness in the context of poverty and service reform". Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/981.
Pełny tekst źródłaSamuriwo, Kuwandandishe Priscilla. "An exploration of methods used by Shona speaking traditional health practitioners in the prevention of mental illness". Thesis, University of Limpopo, 2018. http://hdl.handle.net/10386/2054.
Pełny tekst źródłaStudies by the World Health Organisation have shown that mental illness is an international health concern across the globe, with one in four people (25%) suffering from mental disorders in both developed and developing countries. In many African countries traditional health practitioners are the health care providers of choice for individuals, families and communities. The aim of this study was to explore methods used by Shona speaking traditional health practitioners in the prevention of mental illness in Bulawayo, Zimbabwe. A qualitative research design was used in the present study. Ten Shona speaking traditional health practitioners (male=9; female=1) were selected through purposive sampling and requested to participate in the study. Data was collected using semi-structured interviews and analysed through thematic content analysis. It was found that traditional healers tend to commonly understand and conceptualise mental illness in terms of the causes instead attaching nosological labels to these conditions. The findings of the study also show that most of the traditional health practitioners interviewed had similar methods of preventing mental illness both in families and individuals. Culture was found to be central in shaping how the traditional health practitioners understand and prevent mental illness. Ancestors were found to be pivotal in specifically determining the methods to prevent mental illness for each client. The study is concluded by recommending closer collaboration between the dominant Western health care system and traditional healing in order to improve mental health care provision in Zimbabwe.
Welch, Mark, University of Western Sydney i Faculty of Nursing and Health Studies. "Reel madness : the representation of madness in popular western film". THESIS_FNHS_XXX_Welch_M.xml, 1997. http://handle.uws.edu.au:8081/1959.7/705.
Pełny tekst źródłaDoctor of Philosophy (Hons)
Zhang, Ying. "Exploring functional genetic variants in genes involved in mental disorders". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186433668.
Pełny tekst źródłaBrans, Suzanne. "Applying the social cognitive and sociological models of stigma to student attitudes towards major depression and bipolar disorder". University of Western Australia. School of Psychology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0041.
Pełny tekst źródłaSmit, B. L. "Knowledge and perceptions of University of Limpopo (Turfloop Campus) undergraduate students towards mental illness". Thesis, University of Limpopo, 2018. http://hdl.handle.net/10386/2338.
Pełny tekst źródłaCurrent understandings of mental illness are deeply rooted in a predominantly westernised paradigms of mental health. Constructs such as mental illness have been found to be socially constructed and rooted in historical contexts and informed by cultural and societal influences. Most of the existing research conducted on the knowledge and perceptions of tertiary-educated individuals towards mental illness have been quantitative in nature. The aim of this study was to qualitatively explore the knowledge and perceptions of undergraduates using Social Representation Theory as a theoretical framework. Purposive sampling was utilised to draw a sample of 16 undergraduate students between the ages of 18-25 years, at the University of Limpopo (Turfloop Campus). Thematic Content Analysis (TCA) was used to analyse the semi-structured interviews which were used to collect data. The results of this study found that negative views and perceptions existed amongst the sample pertaining to mental illness and the mentally ill. It was also found that participants conceptualisations of mental illness were not wholly western or traditionally African. Participants perceptions were informed through their cultural and social experiences with the mentally ill. Generally, the study pointed towards a greater need for psycho-education on mental illness.
Moulding, Nicole. "Disciplining the feminine: the reproduction of gender contradictions in mental health care /". Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phm9263.pdf.
Pełny tekst źródłaSharples, Rosemary. "Negotiating 'normal' : space, illness and identity in an alternative mental health resource in Montreal". Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19743.
Pełny tekst źródłaLigthelm, Elizabeth. "Parental mental health and perceived parenting of children with disruptive behaviour disorders". Thesis, Nelson Mandela Metropolitan University, 2013.
Znajdź pełny tekst źródłaLau, Ping-kei Simon, i 劉炳麒. "Attitudes toward the mentally handicapped". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31249814.
Pełny tekst źródłaAlvarado, Chavarría María Jimena. "Let's Try to Change It: Psychiatric Stigmatization, Consumer/Survivor Activism, and the Link and Phelan Model". PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/904.
Pełny tekst źródłaTemmingh, Hendrik. "Epidemiology, diagnosis and aspects of treatment in persons with serious mental illness and co-occurring substance use disorders". Doctoral thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30422.
Pełny tekst źródłaChu, Siu-man, i 朱小敏. "The role of religion in coping with mental disorder". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B43895256.
Pełny tekst źródłaMakgato, Lephai Irene. "Perceptions of learners in selected rural secondary schools towards mental illness : the case of Ga-Dikgale Community, Limpopo Province". Thesis, University of Limpopo, 2020. http://hdl.handle.net/10386/3362.
Pełny tekst źródłaThe growing number of young people in schools presenting with mental illness is increasingly becoming a disconcerting issue locally and globally. This qualitative study sought to explore the perceptions of mental illness by learners drawn from four secondary schools in Ga-Dikgale rural community (Limpopo Province). Twenty-seven learners (males = 14; females = 13) were selected through purposive sampling and requested to participate in the study. Semi-structured individual interviews and focus group discussions (n = 2) were conducted. The following three themes emerged from the data: a) Knowledge of mental illness, its causes and symptoms b) Knowledge on the management and types of interventions needed for mental illness c) Challenges associated with mentally ill people. The themes and sub-themes emerging suggested deep seated Afrocentric cultural perceptions which tended to shape learners’ views and understanding of mental illness. Some paradoxical explanations with regard to mental illness also emerged. Based on the findings of the study, it is recommended that mental health literacy campaigns be conducted in schools
VLIR-UOS
丁錫全 i Sik-chuen Dick Ting. "Relationship of psychotic symptoms to sex offending: a retrospective study of sex offenders with mentaldisorders". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39558162.
Pełny tekst źródłaMurray, Aoife Maureen. "Investigating the role of ZDHHC9 in intellectual disability". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648223.
Pełny tekst źródłaTerry, Rachel Elizabeth. "The Influence of Sense of Community on the Relationship Between Community Participation and Recovery for Individuals with Serious Mental Illnesses". PDXScholar, 2017. https://pdxscholar.library.pdx.edu/open_access_etds/3679.
Pełny tekst źródłaHu, Chiyi, i 胡赤怡. "The impact of migration and mental disorders on suicidal behaviors: an epidemiological survey among generalpopulation in Shenzhen, China". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41757841.
Pełny tekst źródłaLütticke, Ashley L. [Verfasser], i Thomas [Akademischer Betreuer] Schulze. "Understanding the involvement of environmental exposures, genetic risk, and epigenetic mechanisms in the course of severe mental illness / Ashley L. Lütticke ; Betreuer: Thomas Schulze". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1216417806/34.
Pełny tekst źródłaSmith, Lesley-Ann. "'Mad, bad and dangerous to know' : exploring the everyday spaces of older, mental health service users". Thesis, University of Northampton, 2012. http://nectar.northampton.ac.uk/5423/.
Pełny tekst źródłaWalburn, Kathryn H. "Males' and Females' Attitudes Toward a Prospective Social Group Member with a History of Mental Illness". UNF Digital Commons, 1986. http://digitalcommons.unf.edu/etd/656.
Pełny tekst źródłaMungadze, Jerry Jesphat. "A Descriptive Study of a Native African Mental Health Problem Known in Zimbabwe as zvirwere zvechivanhu". Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc332278/.
Pełny tekst źródłaWelch, Mark. "Reel madness : the representation of madness in popular western film". Thesis, View thesis, 1997. http://handle.uws.edu.au:8081/1959.7/705.
Pełny tekst źródłaMitjans, Niubó Marina. "Genetic Risk Factors for the Lack of Response to Clinical Treatment in Mental Disorders: an Approach from Pharmacogenetics". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/289981.
Pełny tekst źródłaLos trastornos mentales graves, como son la depresión mayor (DM), el trastorno bipolar (TB) y la esquizofrenia (SCZ), se han convertido en los últimos años en un importante problema de salud en los países desarrollados. Aunque el avance alcanzado en el desarrollo de tratamientos farmacológicos ha constituido uno de los grandes logros de la psiquiatría moderna, no debemos olvidar que hay un porcentaje muy alto de pacientes que no reciben el tratamiento adecuado para su enfermedad. En este sentido, la farmacogenética tiene como objetivo identificar y caracterizar los factores genéticos que se encuentran en la base de las diferencias existentes entre individuos en la respuesta clínica al tratamiento farmacológico. La presente tesis pretende estudiar variación genética basada en genes que codifican para moléculas implicadas directamente o indirectamente en los mecanismos de acción del tratamiento con citalopram (DM), carbonato de litio (TB) y clozapina (SCZ) que nos explicará parte del riesgo para la no respuesta clínica y la no remisión del episodio tratado farmacológicamente. Los resultados nos permitieron identificar variación genética asociada a la respuesta al tratamiento. Concretamente, nuestros resultados indicaron que variabilidad genética relacionada con el sistema endocannabinoide se asociaba con la respuesta a citalopram en DM. Por otro lado, genes involucrados con el sistema de fosfoinositoles podrían explican parte de la variación en la respuesta al litio en el TB. En referencia al estudio de la respuesta a clozapina en pacientes con SCZ, los resultados sugieren que variantes genéticas en los genes FKBP5 y NTRK2 pueden jugar un papel en la respuesta. En este sentido, nuestro estudio proporciona evidencia de la implicación del eje hipotálamo-pituitario-adrenal (HPA) y de factores neurotróficos en la modulación de la respuesta a clozapina. La detección de diferencias genéticas individuales en la respuesta a los fármacos psicotrópicos puede proporcionar nuevas estrategias para el tratamiento de trastornos mentales, así como, nuevos conocimientos sobre la etiología de estos trastornos.
Wright, Galen Egan Buckley. "Molecular genetic analysis of two genes, CYP2D6 and COMT, in the schizophrenia-susceptibility locus on chromosome 22q in the Xhosa population". Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20366.
Pełny tekst źródłaRedko, Cristina Pozzi. "Fighting against the "evil" : religious and cultural construction of the first psychotic experience of youth living in Sao Paulo, Brazil". Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37817.
Pełny tekst źródłaI emphasized the basic strategies created by psychotic patients and their families to reorganize their experience of themselves and of the world, and the dynamics and underpinning of these strategies in relation to cultural signifiers. I particularly explored how psychotic patients and their families appropriate, borrow and transform cultural signifiers, and more specifically religious signifiers, in their attempt to cope with psychosis. Religious signifiers are pervasive and diverse in Brazilian culture; furthermore different people may or may not resort to or be affected by religious idioms and signifiers in a similar way. A wide range of variation in the use of religious idioms and signifiers can be expected among patients, at different moments of their life history, and when the experiences of patients and significant others are compared. Religion can have a positive impact over the experience of psychosis, a negative, or even a neutral impact depending on the person and circumstances.
My work also demonstrates that psychotic patients are subjected to a double-process of marginality due to their poor living conditions and to urban violence; and to the fact that their marginality is further accentuated by the psychotic episode. People's reactions also vary and change in relation to the kinds of behaviours manifested by psychotic patients, in addition to the social role of each family member and the family dynamics at play. More generally, people's reactions work in a kind of "feed-back loop," since family reactions modify the subjective world and reactions of patients, while patients' reactions modify family attitudes and behaviours.
Hartley, Mary. "Depressed mood in pregnancy : prevalence and social factors in Cape Town peri-urban settlements". Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5324.
Pełny tekst źródłaENGLISH ABSTRACT: The purpose of this study was to determine the prevalence of antenatal distress in Cape Town periurban settlements, and the social factors associated with it in this population. Participants were 756 pregnant women from Khayelitsha and Mfuleni, Cape Town. Each women was interviewed in her home language using a structured questionnaire which included the Edinburgh Postnatal Depression Scale (EPDS), measures for social support and alcohol use, and questions concerning socio-demographics, intimate partner violence, and the current pregnancy. A threshold score of 14 and above on the EPDS was used to determine antenatal distress. Data were analysed using descriptive statistics and bivariate analysis initially, followed by multivariate logistical regression. Results indicated a prevalence of 46% for antenatal distress, which is substantially greater than the prevalence found in high income countries. Women in their first trimester of pregnancy were more likely to experience antenatal distress than were women in their second and third trimesters. The strongest predictors of antenatal distress were poor partner support, intimate partner violence and having a household income below R2000 per month. The high prevalence found in this study has harmful implications for infant health in South Africa, and is reason to suggest that early screening and intervention is crucial. More research is needed to develop and evaluate the effectiveness and scalability of community-based interventions for maternal depression in South African peri-urban settlements, as well as to establish the specific infant outcomes of antenatal distress in this population.
AFRIKAANSE OPSOMMING: Hierdie studie het ten doel om die voorkoms van voorgeboorteangs in buitestedelike nedersettings in Kaapstad te bepaal, sowel as die maatskaplike faktore wat met voorgeboorteangs by dié populasie verband hou. Die studiedeelnemers was 756 swanger vroue van Khayelitsha en Mfuleni, Kaapstad. ʼn Gestruktureerde vraelys is gebruik om met elke vrou ʼn onderhoud in haar huistaal te voer. Die vraelys het die Edinburg-nageboortedepressieskaal (EPDS), maatstawwe vir maatskaplike steun en alkoholgebruik, en vrae oor sosiodemografie, bedmaatgeweld en die vrou se huidige swangerskap ingesluit. ʼn Drempeltelling van 14 en hoër op die EPDS is gebruik om voorgeboorteangs te bepaal. Die data is aanvanklik met behulp van beskrywende statistiek en tweeveranderlike analise ontleed, waarna dit aan meerveranderlike logistiese regressie onderwerp is. Studieresultate toon ʼn 46%-voorkoms van voorgeboorteangs, wat beduidend hoër is as dié in hoëinkomstelande. Vroue in hul eerste trimester van swangerskap blyk meer geneig te wees om voorgeboorteangs te ervaar as vroue in hul tweede en derde trimester. Die sterkste voorspellers van voorgeboorteangs is swak ondersteuning van lewensmaats, bedmaatgeweld en ʼn huishoudelike inkomste onder R2 000 per maand. Die hoë voorkomssyfer van voorgeboorteangs waarop die studie dui, het nadelige implikasies vir babagesondheid in Suid-Afrika, en maak vroeë toetsing en ingryping noodsaaklik. Verdere navorsing word vereis om die doeltreffendheid en skaleerbaarheid van gemeenskapsgegronde ingrypings vir moederdepressie in Suid-Afrikaanse buitestedelike nedersettings te ontwikkel en te beoordeel, sowel as om die bepaalde uitwerkings van voorgeboorteangs op pasgeborenes in dié populasie te bepaal
Herbst, Elsa. "The illness experience of HIV-infected low-income Coloured mothers in the Winelands region : theoretical and practical implications". Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019/548.
Pełny tekst źródłaNiehaus, Daniel Jan Hendrik. "Limiting clinical heterogeneity in schizophrenia : can affected Xhosa sib pairs provide valid subtypes?" Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/1435.
Pełny tekst źródłaBACKGROUND Schizophrenia is a heterogeneous disorder, which has been shown to have both environmental and genetic risk factors. Since family history (genetic loading) of psychosis appears to be one of the strongest risk factors for the development of schizophrenia, the investigation of affected sib pairs can be used to explore shared familial factors. The Xhosa-speaking inhabitants in the Western, Eastern and Southern Cape provinces, an African population of relatively homogeneous ethnicity, provided a sample of the first large clinical phenotype of schizophrenia. AIM The main aim of this study was to identify shared symptoms or symptom clusters in a sample of Xhosa-speaking sib pairs, with the aid of structured assessment tools.
Farquharson, Kirsten Leigh. "Audience observations of art, identity and schizophrenia : possibilities for identity movement". Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1012992.
Pełny tekst źródłaStorkey, Karen. "The prevalence of depressive symptoms in the prepartum and postpartum period : a study of low-income women in the Western Cape, South Africa". Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2268.
Pełny tekst źródłaThis study aimed to determine whether low-income women residing in a rural community in South Africa experienced any significant difference in the prevalence rates of depressive symptoms postpartum as compared to depressive symptoms prepartum. Thirty women between the ages of 16 and 38 were recruited during pregnancy from the local community clinic in Kylemore, South Africa. The women where assessed for elevated levels of depressive symptomatology using the Beck Depression Inventory (BDI) during pregnancy and again at three and six months postpartum. It was found that 18 (60%) of the women reported elevated levels of depressive symptomatology during the prepartum assessment, with 11 (37.9%) and 12 (48%) women reporting elevated levels of depressive symptomatology at the three months and six month postpartum assessment respectively. It was further found that the sample from the current study did not experience any significant difference in the rate of depressive symptomatology from the prepartum assessment to either of the postpartum assessments. The results also suggests that a relationship exists between the levels of depressive symptomatology prepartum and the levels of depressive symptomatology postpartum, as those women who experienced high levels of depressive symptomatology during pregnancy continued to show high levels of depressive symptomatology at the postpartum assessments. The findings from the current study thus suggest that the classification of postpartum depression as a unique and separate entity, that differs from depression occurring in women at other times and from depression as experienced by men, may be misleading. The term suggests a depression that develops following childbirth, while in the current study it seemed that when depressive symptoms were reported postpartum, they were also already apparent during pregnancy. The findings from the current study therefore suggest that the existence of postpartum depression as a distinct diagnosis or illness is problematic – a suggestion that has frequently been suggested in the literature (Aderibigbe, Gureje, & Omigbodun, 1993; Chandran, Tharyan, Muliyil & Abraham, 2002; Cooper, Campbell, Day, Kennerly & Bond, 1988; Cox, Murray & Chapman, 1993; O’Hara, Zekoski, Phillips & Wright, 1990; Patel, Rodrigues, & DeSouza, 2002).
Rochat, Tamsen Jean. "Depression among pregnant women testing for HIV in rural South Africa". Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6843.
Pełny tekst źródłaENGLISH ABSTRACT: Pregnancy is a vulnerable time in settings such as sub-Saharan Africa, and is associated with exposure to a multitude of physiological, social and psychological risks. High HIV prevalence, and the fact that many women will test for HIV for the first time during their pregnancy, has raised concern about women‘s psychological health during pregnancy. Depression during the antenatal period is of public health concern as it has been shown to be associated with poorer foetal and delivery outcomes, risky behaviours, and poorer uptake of antenatal care. Antenatal depression is a predictor of postnatal depression, and postnatal depression has been associated with poor maternal sensitivity and attachment in mothers which is known to result in increased behavioural and developmental difficulties in children. The aim of this research was to provide a clear, in depth and culturally sensitive understanding of the manifestation of depression in pregnant women in a rural area with high HIV prevalence in South Africa. The research method included a diagnostic assessment of depression in 109 women in their third trimester of pregnancy, and an in-depth qualitative examination of the contextual framework within which HIV testing and depression are experienced with a sub-sample of 56 women. The quantitative results demonstrated that the prevalence of antenatal depression was high (46.7%), with close to half of the women being diagnosed with depression. Presentations of depression most frequently included disturbances in mood, loss of interest and suicide ideation. Symptoms which overlap with common side effects of pregnancy such as loss of energy and weight change did not result in an overestimation of depression. Likewise, very little evidence of the somatisation of depression, or particular cultural barriers to the diagnosis of depression based on DSM-IV criteria was found. Rates of suicide ideation were high and equally common among HIV positive as HIV negative women. Factors significantly associated with depression included living within a family homestead, access to a regular source of income and practical support from a partner. Both income and partner support had a negative association with depression. Living away from a family or parental home had a positive association with depression. The results showed that the Edinburgh Postnatal Depression Scale (EPDS) was effective in identifying depression and that a shorter three item version was as effective as longer versions. A positive score for depressed mood on the EPDS was significantly associated with HIV, suggesting that the EPDS is a good screening tool for elevated psychological risks among HIV positive women post HIV testing. Qualitative results showed that having an unsupportive partner and the occurrence of relationship or familial conflict played an important role in the development of emotional distress during pregnancy and resulted in a high number of unwanted pregnancies. Partner and familial conflict was intertwined with cultural practices which govern the acceptability of childbearing among unmarried women and the social recognition of partnerships and paternal responsibilities. Testing for HIV was considered a stressful life event for all women regardless of their HIV status and was a particularly negative life event for women who tested HIV positive or for women who had concerns over partner infidelity. Disclosure among HIV positive women frequently lead to increased partnership conflict. Qualitative findings suggested that depression and emotional distress after HIV testing did interfere with women‘s ability to engage with prevention messages. Women who were coping well with learning their HIV positive status had high levels of family disclosure and subsequent family support in common. The implication of this research is that it is important that public health programmes screen for depression among childbearing women. These data suggests that a shorter three item version of the EPDS along with screening for partner and family support or conflict would effectively detect most women at high risk for depression. Likewise, public health interventions for women with depression which are implemented in primary health care facilities and in isolation of the partnership and familial context within which depression occurs are not likely to be effective. Further research is needed to establish the precise prevalence of antenatal and postnatal depression in women at high risk for HIV; to validate the effectiveness of a shorter screening tool in resource limited settings; and to establish risk and protective factors, and trimester specific risks which could inform the design of cost effective interventions in poorly resourced settings.
AFRIKAANSE OPSOMMING: Swangerskap in Afrika, suid van die Sahara, is ʼn kwesbare tydperk met blootstelling aan ʼn menigte fisiologiese, sosiale en sielkundige risiko‘s. Die hoë voorkoms van HIV en die feit dat baie vrouens gedurende swangerskap vir die eerste keer vir HIV wil toets, het ‗n besorgdheid oor vrouens se sielkundige gesondheid gedurende swangerskap laat ontstaan. Depressie gedurende die voorgeboortelike periode is van belang vir publieke gesondheid, want daar is bewyse wat dui op ‗n verband tussen depressie en swakker fetale en geboorte resultate, riskante gedrag en verminderde gebruik van voorgeboortelike sorg . Voorgeboortelike depressie is ʼn indikasie van moontlike nageboortelike depressie en nageboortelike depressie word geassosieer met swak moederlike sensitiwiteit en die gebrekkige vorming van ‗n band tussen moeder en kind; wat reeds bewys is om te lei tot verhoogde gedrags- en ontwikkelingsprobleme in kinders. Die doel van hierdie navorsing was om ʼn duidelike, indiepte en kulturele-sensitiewe begrip van die manifestasie van depressie in swanger vroue in ʼn landelike omgewing met hoë HIV voorkoms in Suid Afrika te verkry. Die navorsingsmetode sluit in ʼn simptomatiese beraming van depressie by 109 vroue in hul derde trimester van swangerskap en ʼn indiepte kwalitatiewe ondersoek na die kontekstuele raamwerk waarbinne HIV toetse en depressie ondervind word met ʼn sub-steekproef van 56 vrouens. Die bevinding was dat die voorkoms van voorgeboortelike depressie hoog was, 46.7 %, met feitlik die helfte van die vrouens wat met depressie gediagnoseer is. In die meeste gevalle het die voorkoms van depressie gepaard gegaan met ʼn verandering in gemoedstoestand, ʼn verlies aan belangstelling en selfmoordgedagtes. Simptome wat ooreenstem met algemene newe-effekte van swangerskap, soos verlies aan energie en verandering in gewig, het nie bygedra tot ʼn oorberekening van depressie nie. Soortgelyk is baie min bewyse gevind dat somatosasie van depressie, of spesifieke kulturele grense, tot die diagnose van depressie gebaseer op DSM-IVkriteria bydra. Die oorweging van selfmoord was hoog en algemeen tussen beide HIV-positiewe en HIV-negatiewe vouens. Faktore wat aansienlik met depressie geassosieer word, sluit in om in ʼn familiegroep te bly, toegang tot ʼn vaste bron van inkomste en die praktiese ondersteuning van ʼn lewensmaat. Beide inkomste en die ondersteuning van ʼn lewensmaat het ʼn negatiewe verbintenis met depressive. Om nie by familie of in ʼn ouerhuis te bly nie het ʼn positiewe assosiasie met depressive. Alhoewel HIV-status verband hou met depressie, was dit nie uitermate die geval nie, alhoewel daar ʼn gebrek aan statistiese kragdoeltreffendheid was om die effek van HIV vas te stel, gegee die beperkte grootte van die steekproef. Die resultate het getoon dat die EPDS graderingsinstrument effektief was om depressie te identifiseer en dat ʼn korter driepunt weergawe daarvan net so effektief was soos die langer weergawe. ʼn Positiewe telling vir ʼn depressiewe gemoedstoestand op die EPDS het ʼn betekenisvolle assosiasie met HIV en dui daarop dat die EPDS ʼn goeie graderingsinstrument is vir verhoogde sielkundige risiko by HIV-positiewe vrouens, selfs al is HIV-positiewe vrouens in dié steekproef statistieksgewys nie meer geneig tot depressie as HIV-negatiewe vrouens nie. Kwalitatiewe resultate toon dat ʼn lewensmaat wat nie ondersteunend is nie en die voorkoms van verhoudings- of familiekonflik ʼn belangrike rol speel in die ontwikkeling van emosionele angs gedurende swangerskap en dit het gelei tot ʼn groot aantal ongewenste swangerskappe. Konflik met ʼn lewensmaat en met familie was verweefd met kulturele gebruike wat die aanvaarbaarheid van geboortes onder ongetroude vrouens beheer en die sosiale erkenning van verhoudings en die vader se verantwoordelikhede. ʼn HIV-toets is as ʼn stresvolle lewensgebeurtenis beskou deur alle vroue, ongeag van hulle HIV-status en was ʼn besondere negatiewe lewensgebeurtenis vir vroue wat HIV-positief getoets het of vir vroue wat bekommerd was oor hulle lewensmaats se getrouheid. Onthulling van die HIV-status van positiewe vrouens het gereeld tot verhoogde konflik in verhoudings gelei. Kwalitatiewe bevindings dui daarop dat depressie en emosionele angs na ʼn HIV-toets inmeng met ʼn vrou se vermoë om ag te slaan op voorkomingsboodskappe. Vroue wat die kennis van hulle HIV-positiewe status goed hanteer het, het hoë vlakke van bekendmaking van hulle status en die ondersteuning van hulle familie in gemeen. Die implikasie van die navorsing is dat dit belangrik is vir publieke gesondheidsorgprogramme om te toets vir depressie onder swanger vroue. Die resultate dui daarop dat ʼn korter driepunt weergawe van die EPDS, saam met ʼn ondersoek na die ondersteuning van of konflik met ʼn lewensmaat en familie, effektief kan wees om vroue met ʼn hoë risiko vir depressie te identifiseer. Soortgelyk, publieke gesondheidsingryping in primêre gesondheidsorg fasiliteite vir vroue met depressie wat in isolasie van die lewensmaat en familie konteks, waar depressie voorkom geadministreer word, is onwaarskynlik om te slaag. Bevindings onderskryf die belangrikheid van ondersteuning vir die familie om effektief te kan reageer en herstel van stresvolle faktore soos onbeplande swangerskappe en HIV-diagnose, in ʼn konteks wat swaar deur HIV geaffekteer word, aangesien dit ʼn voorkomende effek op depressie kan hê. Verdere navorsing is nodig om die presiese voorkoms van voorgeboortelike en nageboortelike depressie in vrouens met ʼn hoë blootstelling aan HIV vas te stel; om die sukses van ʼn korter graderingsinstrument in arm omgewings te staaf; en om die risiko en beskermende faktore vas te stel en trimester spesifieke risiko‘s wat die ontwerp van ʼn koste-effektiewe ingryping in gebiede met ontoereikende hulpbronne kan beïnvloed.
Suthers, Graeme Kemble. "The human gene map near the fragile X /". Title page, table of contents and summary only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phs966.pdf.
Pełny tekst źródłaTypescript (Photocopy). Includes published papers co-authored by the author at the end of volume 2. Includes bibliographical references (leaves 195-237 of vol. 1).
Theander, Freja, i Sofia Selenius. "Appar vid vård av psykisk ohälsa : En kvalitativ studie om psykiatripatienters attityder och behov". Thesis, Uppsala universitet, Institutionen för informatik och media, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355083.
Pełny tekst źródłaMental illness is increasing, both globally and in Sweden. Meanwhile it is reported that the psychiatric care is inadequate because of its low availability. A solution to this problem is to increase the availability of care through a smartphone application. But no matter how effective an app might be, it will not solve anything if it is not used. The purpose of this study is therefore to investigate attitudes towards this kind of digitalization and to examine what kind of app functions that can meet patients needs. The study is based on qualitative interviews with persons that have received care from the psychiatry at Akademiska sjukhuset in Uppsala, Sweden. Furthermore, we analyze the empirical material by using the theoretical framework Technology Acceptance Model (TAM). The results show that all of the participating patients generally have positive attitudes towards the concept of using apps for mental health care. Although, these positive attitudes require that a mental health app should be complementary to the psychiatric care available today, not replace it. Finally, the study also suggests that application functions that are well suited to meet the needs of the patients are those who make the mental health care more available by providing information rather than offering treatment through the application.
Koen, Liezl. "Chromosomal aberrations in the Xhosa schizophrenia population". Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1189.
Pełny tekst źródłaBACKGROUND: Schizophrenia is a heterogeneous illness resulting from complex gene-environment interplay. The majority of molecular genetic work done has involved Caucasian populations, with studies in these and Asian populations showing 2-32% of sufferers to have chromosomal aberrations. So far the discovery of a specific susceptibility mechanism or gene still eludes us, but the use of endophenotypes is advocated as a useful tool in this search. No cytogenetic studies of this nature have been reported in any African schizophrenia population. AIM: The aim of the study was to combine genotypic and phenotypic data, collected in a homogenous population in a structured manner, with the hope of characterising an endophenotype that could be used for more accurate identification of individuals with possible chromosomal abnormalities. METHODOLOGY: A structured clinical interview was conducted on 112 Xhosa schizophrenia patients. (Diagnostic Interview for Genetic Studies, including Schedules for the Assessment of Negative and Positive Symptoms.) Blood samples (karyotyping and/or FISH analysis) as well as urine samples (drug screening) were obtained and nine head and facial measurements were performed. Descriptive statistics were compiled with reference to demographic, clinical and morphological variables. Comparisons between mean differences for these variables were made.
Rodrigues, Natalia Fintelman. "Caracterização de alterações epigenéticas no gene JARID1C e desequilíbrios genéticos como causas do retardo mental ligado ao x de etiologia idiopática". Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2963.
Pełny tekst źródłaO retardo mental (RM) é caracterizado por um funcionamento intelectual significantemente abaixo da média (QI<70). A prevalência de RM varia entre estudos epidemiológicos, sendo estimada em 2-3% da população mundial, constituindo assim, um dos mais importantes problemas de saúde pública. Há um consenso geral de que o RM é mais comum no sexo masculino, um achado atribuído às numerosas mutações nos genes encontrados no cromossomo X, levando ao retardo mental ligado ao X (RMLX). Dentre os genes presentes no cromossomo X, o Jumonji AT-rich interactive domain IC (JARID1C) foi recentemente identificado como um potencial candidato etiológico do RM, quando mutado. O JARID1C codifica uma proteína que atua como uma desmetilase da lisina 4 da histona H3 (H3K4), imprescindível para a regulação epigenética. Tão recente como a identificação do gene JARID1C, é a descoberta de que mudanças no número de cópias de sequências de DNA, caracterizadas por microdeleções e microduplicações, poderiam ser consideradas como razões funcionalmente importantes de RMLX. Atualmente, cerca de 5-10% dos casos de RM em homens são reconhecidos por ocorrerem devido a estas variações do número de cópias no cromossomo X. Neste estudo, investigamos mutações no gene JARID1C, através do rastreamento dos éxons 9, 11, 12, 13, 15 e 16, em 121 homens de famílias com RM provavelmente ligado ao X. Paralelamente, realizamos a análise da variação do número de cópias em 16 genes localizados no cromossomo X através da técnica de MLPA no mesmo grupo de pacientes. Esta metodologia consiste em uma amplificação múltipla que detecta variações no número de cópias de até 50 sequências diferentes de DNA genômico, sendo capaz de distinguir sequências que diferem em apenas um nucleotídeo. O DNA genômico foi extraído a partir de sangue periférico e as amostras foram amplificadas pela técnica de PCR, seguida da análise por sequenciamento direto. Foram identificadas três variantes na sequência do gene JARID1C entre os pacientes analisados: a variante intrônica 2243+11 G>T, que esteve presente em 67% dos pacientes, a variante silenciosa c.1794C>G e a mutação inédita nonsense c.2172C>A, ambas presentes em 0,82% dos indivíduos investigados. A análise através do MLPA revelou uma duplicação em um dos pacientes envolvendo as sondas referentes ao gene GDI1 e ao gene HUWE1. Este trabalho expande o estudo de mutações no gene JARID1C para a população brasileira ereforça a importância da triagem de mutações neste gene em homens portadores de RM familiar de origem idiopática, assim como, é primeiro relato científico relativo à investigação de variações no número de cópias de genes localizados no cromossomo X em homens brasileiros com RM, através da técnica de MLPA.
Mental retardation (MR) is defined as a disability characterized by significant below average intellectual functioning (IQ>70). The prevalence of MR varies between epidemiological studies, estimated at 2-3% of the population, thus constituting a major public health problem. There is a general consensus that MR is more common in males, a finding attributed, in part, to mutations in the genes located on the X chromosome, leading to an X-linked mental retardation (XLMR). Among all the genes present on X chromosome, Jumonji AT-rich interactive domain IC (JARID1C) was recently identified as aetiologic potential candidate of MR, when mutated. The JARID1C gene encodes a protein that acts as a histone demethylase specific for histone 3 lysine 4 (H3K4) and it is indispensable for the epigenetic regulation. As recently as the identification of the JARID1C gene, it is the discovery that changes in the number of copies of DNA sequences, characterized by microdeletions and microduplications, could be regarded as functionally important reasons to XLMR. Currently, about 5-10% of men MR cases are known to occur due to these variations in the number of copies of chromosome X. In this study we investigated mutations in the JARID1C gene by screening of exons 9, 11, 12, 13, 15 and 16 in 121 patients from families with X-linked MR. At the same time we analyzed the variation in the number of copies in 16 genes located in X chromosome through the MLPA technique. This metodology consists of a multiplex amplification that detects variations in the number of copies up to 50 different genomic DNA sequences, being able to distinguish sequences that differ by only one nucleotide. Genomic DNA was extracted from peripheral blood and the samples were amplified by PCR followed by direct sequencing analysis. We identified three sequence variants among 121 patients. The intronic variant c.2243 +11 G> T, which was present in 67% of patients analyzed, the silent variant c.1794C> G and the novel nonsense mutation c.2172C> A, which was present in 0,82% of patients analyzed. The MLPA analysis revealed that the patient 58 exhibited a duplication involving probes for the GDI1 gene and the HUWE1 gene, resulting in an increase in the number of copies of this gene. This work expands the study of mutations in the JARID1C gene for the Brazilian population and reinforces the importance of screening for mutations in this gene in men with idiopathic mental retardation, and it is the first scientific report on the investigation of variations in the number of copies in genes located on chromosome X in Brazilian men with MR using the MLPA technique.
Obiols, Guardia Aida. "El transcriptoma no codificante en Síndrome de Rett: nuevas funciones para las regiones transcritas ultraconservadas y circRNAs". Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671629.
Pełny tekst źródłaNkuna, Thembi. "Experiences of family members of persons living with mental illness in Capricorn District, Limpopo Province; South Africa". Thesis, 2019. http://hdl.handle.net/10386/3127.
Pełny tekst źródłaBackground- care of the mentally ill by family members is done with little or no supervision by skilled health workers. Therefore, the purpose of the study was to investigate the experiences of family members of patients living with mental illness in the Capricorn District of Limpopo Province in South Africa. Objective- to explore and describe the experiences of family members caring for patients living with mental illness. Methods- A qualitative, descriptive and exploratory design was used. Non-probability sampling of the purposive and convenient type was used to explore and describe the experiences of family members of patients living with mental illness in the Capricorn District. Data were collected from fifteen family members caring for MHCUs, by using open-ended semi-structured face-to-face interviews. Data were audio recorded and observations were done during interviews. Trustworthiness was ensured by applying credibility, transferability, confirmability and dependability. Data were analysed using Tech’s open-coding method. Results- family members experience disruptive behaviour from MHCUs and they also have to adapt to new routines that are at times unfavourable. As a result, the family members’ health and quality of life are affected, thus making them susceptible to having mental illness and other medical conditions as well. Conclusion- There is a need for family members caring for persons living with mental illness to be given emotional and social support. community projects such as support groups for family members caring for MHCUs and goal directed standard operations procedures at the Psychiatric Ward – specifically designed and implemented for family members caring for MHCUs, are recommended.
Kalal, Beth Ann Burdick. "Clinical, social, and demographic predictors of the one-year outcome of first-incidence psychosis in Hawaii". Thesis, 1989. http://hdl.handle.net/10125/10208.
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