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Artykuły w czasopismach na temat „Melatonin”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Tan, Dun-Xian, and Rüdiger Hardeland. "The Reserve/Maximum Capacity of Melatonin’s Synthetic Function for the Potential Dimorphism of Melatonin Production and Its Biological Significance in Mammals." Molecules 26, no. 23 (2021): 7302. http://dx.doi.org/10.3390/molecules26237302.

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In this article, we attempt to classify a potential dimorphism of melatonin production. Thus, a new concept of “reserve or maximum capacity of melatonin synthetic function” is introduced to explain the subtle dimorphism of melatonin production in mammals. Considering ASMT/ASMTL genes in the pseudoautosomal region of sex chromosomes with high prevalence of mutation in males, as well as the sex bias of the mitochondria in which melatonin is synthesized, we hypothesize the existence of a dimorphism in melatonin production to favor females, which are assumed to possess a higher reserve capacity fo

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Wang, Tong-Hong, Chuen Hsueh, Chin-Chuan Chen, et al. "Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction." International Journal of Molecular Sciences 19, no. 9 (2018): 2687. http://dx.doi.org/10.3390/ijms19092687.

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Melatonin is the main pineal hormone that relays light/dark-cycle information to the circadian system. Recent studies have examined the intrinsic antitumor activity of melatonin in various cancers, including hepatocellular carcinoma (HCC), the primary life-threatening malignancy in both sexes in Taiwan. However, the detailed regulatory mechanisms underlying melatonin’s anti-HCC activity remain incompletely understood. Here, we investigated the mechanisms by which the anti-HCC activity of melatonin is regulated. Human hepatoma cell lines were treated with 1 and 2 mM melatonin, and functional as

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Maitra, Sayantan, Debanjan Bhattacharya, Stabak Das, and Subhrajit Bhattacharya. "Melatonin and its anti-glioma functions: a comprehensive review." Reviews in the Neurosciences 30, no. 5 (2019): 527–41. http://dx.doi.org/10.1515/revneuro-2018-0041.

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Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a naturally synthesized hormone secreted from the pineal gland in a variety of animals and is primarily involved in the regulation of the circadian rhythm, which is the natural cycle controlling sleep in organisms. Melatonin acts on specific receptors and has an important role in overall energy metabolism. This review encompasses several aspects of melatonin activity, such as synthesis, source, structure, distribution, function, signaling and its role in normal physiology. The review highlights the cellular signaling and messenger systems in

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Moretti, Enrico, Gaia Favero, Luigi Fabrizio Rodella, and Rita Rezzani. "Melatonin’s Antineoplastic Potential Against Glioblastoma." Cells 9, no. 3 (2020): 599. http://dx.doi.org/10.3390/cells9030599.

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Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients’ expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties. Due to evidence demonstrating melatonin’s activity against several cancer hallmarks, there is growing interest in its use for preventing and treating cancer. In this review, we report on the potential effects of melatonin, alone or in combination with anticancer drugs, against GB

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Fernandez-Gil, Beatriz I., Andrea Otamendi-Lopez, Alexandra Bechtle, et al. "Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma." Cells 11, no. 21 (2022): 3467. http://dx.doi.org/10.3390/cells11213467.

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Metabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM tumor initiating cells. GBM tumor initiating cells were treated at different times with melatonin (1.5 and 3.0 mM). We analyzed melatonin’s functional effects on GBM proliferation, cell cycle, viability, stemness, and chemo-radiosensitivity. We then assessed the effects of melatonin on GBM metabolism

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Văn Thoại, Phạm, and Nguyen Hai Nam. "Design and Synthesis of Sustain-Acting Melatonin Prodrugs." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/684760.

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Twelve melatonin amide prodrugs aiming at prolonging the action of melatoninin vivoby improving its half-life were designed and synthesized. Using an 80% human plasma model, it was found that the aliphatic amide derivatives were relatively stable and melatonin release from these compounds was not sufficient with melatonin release percentage. After 4-hour incubation with 80% human plasma, the melatonin release percentage achieved only approximately less than 20%. In contrast, the -succinyl and -glutaroylmelatonin derivatives (compounds11and12, resp.) were found to release melatonin in much high

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Campos, Luciana Aparecida, Ovidiu Constantin Baltatu, Sergio Senar, Rym Ghimouz, Eman Alefishat, and José Cipolla-Neto. "Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders." International Journal of Molecular Sciences 24, no. 1 (2023): 860. http://dx.doi.org/10.3390/ijms24010860.

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Several psychosocial, sleep/circadian, and cardiometabolic disorders have intricately interconnected pathologies involving melatonin disruption. Therefore, we hypothesize that melatonin could be a therapeutic target for treating potential comorbid diseases associated with this triad of psychosocial-sleep/circadian-cardiometabolic disorders. We investigated melatonin’s target prediction and tractability for this triad of disorders. The melatonin’s target prediction for the proposed psychosocial-sleep/circadian-cardiometabolic disorder triad was investigated using databases from Europe PMC, ChEM

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Chakraborty, Souradipta, Razia Khatoon, Aindrila Chattopadhyay, and Debasish Bandyopadhyay. "Emerging role of melatonin in the alleviation of ischemic heart disease: A comprehensive review." INDIAN JOURNAL OF PHYSIOLOGY AND ALLIED SCIENCES 75, no. 04 (2023): 5–12. http://dx.doi.org/10.55184/ijpas.v75i04.139.

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Melatonin, a circardian biomolecule exerts cardioprotective effects through its ability to directly scavenge free radicals and to indirectly act as an antioxidant. It has biological functions such as anti-apoptosis, anti-inflammation, antioxidant activity, mitochondrial protection, and controlling the production of cytokines by target cells. Melatonin also showed blood pressure lowering, normalising lipid profiles, and anti-inflammatory characteristics. Melatonin plays critical roles in averting oxidative stress, enhancing autophagic cell repair, modulating immunological and inflammatory respo

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9

Min, Seung Hyun, Gabriella Gobbi, and Luca Posa. "Melatonin and its Receptors." McGill Science Undergraduate Research Journal 12, no. 1 (2017): 38–43. http://dx.doi.org/10.26443/msurj.v12i1.43.

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Background: Melatonin (5-methoxy-N-acetyltryptamine) is a hormone that has numerous physiological functions. Synthesized and released during nighttime, melatonin exerts its physiological effects in a circadian manner. Melatonin acts by binding to its different types of receptors. The purpose of this systematic review is to summarize recent findings about melatonin, its receptors, and the differential functionalities of the most characterized melatonin receptors MT1 and MT2. Methods: We searched PubMed and Google Scholar for studies that reported melatonin receptor subtypes, their differential

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10

Onaolapo, O. J., A. Y. Onaolapo, O. A. Olowe, M. O. Udoh, D. O. Udoh, and I. T. Nathaniel. "Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders." Current Neuropharmacology 18, no. 7 (2020): 563–77. http://dx.doi.org/10.2174/1570159x18666191230114339.

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Melatonin is a multifunctional signalling molecule that is secreted by the mammalian pineal gland, and also found in a number of organisms including plants and bacteria. Research has continued to uncover an ever-increasing number of processes in which melatonin is known to play crucial roles in mammals. Amongst these functions is its contribution to cell multiplication, differentiation and survival in the brain. Experimental studies show that melatonin can achieve these functions by influencing transcription factors which control neuronal and glial gene expression. Since neuronal survival and

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11

Guerra-Librero, Ana, Beatriz I. Fernandez-Gil, Javier Florido, et al. "Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function." Antioxidants 10, no. 4 (2021): 603. http://dx.doi.org/10.3390/antiox10040603.

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Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the hypoxic microenvironment and is crucial for tumor growth and metastasis, is recognized as one of the major mechanisms underlying therapeutic resistance. Mitochondria, which are directly involved in metabolic reprogramming, are used to design novel mitochondria-targeted anticancer agents. Despite being targeted by melatonin, the functional role of mitochondria in melatonin’s oncostatic activity remains unclear. In this study, we aim to investigate the role of melatonin in mitochondrial metabolism and its

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12

Givler, Donald, Amy Givler, Patrick M. Luther, et al. "Chronic Administration of Melatonin: Physiological and Clinical Considerations." Neurology International 15, no. 1 (2023): 518–33. http://dx.doi.org/10.3390/neurolint15010031.

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Background: Exogenous melatonin is commonly used to treat insomnia, other sleep problems, and numerous medical illnesses, including Alzheimer’s disease, autism spectrum disorder, and mild cognitive impairment in adults and children. There is evolving information regarding issues with the use of chronic melatonin. Methods: The present investigation was a narrative review. Results: Melatonin usage has risen dramatically in recent years. Many countries only allow melatonin prescriptions. In the United States (U.S.), it is classified as a dietary supplement accessible over the counter and can be d

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13

Chen, Zhongyi, Chu Chang Chua, Jinping Gao, Ronald C. Hamdy, and Balvin H. L. Chua. "Protective effect of melatonin on myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 5 (2003): H1618—H1624. http://dx.doi.org/10.1152/ajpheart.00874.2002.

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The dose- and time dependence of melatonin and the effective window of melatonin administration were determined in a mouse model of myocardial infarction. When mouse hearts were subjected to 60 min of occlusion of the left anterior descending artery (LAD) followed by 4 h of reperfusion, melatonin pretreatment for 30 min significantly reduced the infarct size/risk area. The most effective dose was found to be 150 μg/kg intraperitoneally, and the effective period of protection lasted up to 2 h after melatonin administration. Melatonin administration 45 min after LAD ligation or right before repe

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S, Ghosh. "Roles of Melatonin and Phyto-Melatoninas an Anti-Cancer Molecule: An Evolutionary Perspective." Journal of Natural & Ayurvedic Medicine 5, no. 3 (2021): 1–8. http://dx.doi.org/10.23880/jonam-16000316.

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Etymologically, melatonin (N-acetyl-5-methoxytryptamine) can be traced back to the origin of life. The first origin of melatonin was detected in cyano-bacteria. As considering the endosymbiont hypothesis, cyanobacteria were engulfed by the animal and plant cells. Later on, these bacteria performed the roles of mitochondria and chloroplastids in animals and plant cells respectively. Inner matrices of these organelles are having melatonin and probable function of this intra-organelle melatonin is to protect the organelles from the detrimental effects from free radicals (Reactive Oxygen Species;

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Lalanne, Sébastien, Claire Fougerou-Leurent, George M. Anderson, et al. "Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder." International Journal of Molecular Sciences 22, no. 3 (2021): 1490. http://dx.doi.org/10.3390/ijms22031490.

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The role of melatonin has been extensively investigated in pathophysiological conditions, including autism spectrum disorder (ASD). Reduced melatonin secretion has been reported in ASD and led to many clinical trials using immediate-release and prolonged-release oral formulations of melatonin. However, melatonin’s effects in ASD and the choice of formulation type require further study. Therapeutic benefits of melatonin on sleep disorders in ASD were observed, notably on sleep latency and sleep quality. Importantly, melatonin may also have a role in improving autistic behavioral impairments. Th

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Sohn, Eun-Hwa, Su-Nam Kim, and Sung-Ryul Lee. "Melatonin’s Impact on Wound Healing." Antioxidants 13, no. 10 (2024): 1197. http://dx.doi.org/10.3390/antiox13101197.

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Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin’s effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. Whil

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Tan, Dun-Xian, and Russel J. Reiter. "An evolutionary view of melatonin synthesis and metabolism related to its biological functions in plants." Journal of Experimental Botany 71, no. 16 (2020): 4677–89. http://dx.doi.org/10.1093/jxb/eraa235.

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Abstract Plant melatonin research is a rapidly developing field. A variety of isoforms of melatonin’s biosynthetic enzymes are present in different plants. Due to the different origins, they exhibit independent responses to the variable environmental stimuli. The locations for melatonin biosynthesis in plants are chloroplasts and mitochondria. These organelles have inherited their melatonin biosynthetic capacities from their bacterial ancestors. Under ideal conditions, chloroplasts are the main sites of melatonin biosynthesis. If the chloroplast pathway is blocked for any reason, the mitochond

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Mondes, Pedro Henrique de Lima, and Eduardo Koji Tamura. "Melatonina em Animais de Companhia: uma Revisão de Literatura." Ensaios e Ciência C Biológicas Agrárias e da Saúde 25, no. 5-esp (2022): 671–81. http://dx.doi.org/10.17921/1415-6938.2021v25n5-espp671-681.

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A melatonina, N-acetil-5-metoxi-triptamina, é uma indolamina que possui diversas ações no organismo, desde regulação de ritmos circadianos, modulação do sistema imune, indutor do sono em determinas espécies e até eliminação de radicais livres. O objetivo desta revisão foi descrever o histórico, a síntese, os mecanismos de ação e os efeitos da melatonina, além de descrever trabalhos que utilizaram a melatonina em patologias associadas aos animais domésticos, em especial, nos cães e nos gatos. Esta revisão pode ser classificada como integrativa, com metodologia que consistiu em selecionar artigo

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Mondes, Pedro Henrique de Lima, and Eduardo Koji Tamura. "Melatonina em Animais de Companhia: uma Revisão de Literatura." Ensaios e Ciência C Biológicas Agrárias e da Saúde 25, no. 5-esp. (2022): 671–81. http://dx.doi.org/10.17921/1415-6938.2021v25n5-esp.p671-681.

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A melatonina, N-acetil-5-metoxi-triptamina, é uma indolamina que possui diversas ações no organismo, desde regulação de ritmos circadianos, modulação do sistema imune, indutor do sono em determinas espécies e até eliminação de radicais livres. O objetivo desta revisão foi descrever o histórico, a síntese, os mecanismos de ação e os efeitos da melatonina, além de descrever trabalhos que utilizaram a melatonina em patologias associadas aos animais domésticos, em especial, nos cães e nos gatos. Esta revisão pode ser classificada como integrativa, com metodologia que consistiu em selecionar artigo

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Ablaikhanova, N. T., A. A. Nildibayeva, А. Y. Yessenbekova, et al. "The influence of melatonin on the functional state of the human body during desynchronosis." Bulletin of the Karaganda University “Biology medicine geography Series” 11529, no. 3 (2024): 101–9. http://dx.doi.org/10.31489/2024bmg3/101-109.

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In the article the mechanisms of melatonin action in the human body, exploring its impact on circadian rhythms, sleep, the immune system, and overall physiological function were considered. A focal point is the use of melatonin as a pharmacological tool to address dyssynchrony, particularly in students facing new time zones or geographic latitude changes. The study aims to understand melatonin's potential influence on regulating biological rhythms and the general physiological state in such scenarios. It scrutinizes how melatonin affects circadian rhythms, sleep, activity, and overall physiolo

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Szataniak, Ida, and Kacper Packi. "Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review." International Journal of Molecular Sciences 26, no. 14 (2025): 6731. https://doi.org/10.3390/ijms26146731.

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Sleep deprivation impairs immune function, and melatonin has emerged as a key mediator in this process. This narrative review analyzes 50 studies published between 2000 and 2025 to determine the extent to which reduced melatonin synthesis contributes to immune dysregulation. Consistent sleep loss lowers melatonin levels, which correlates with elevated proinflammatory cytokines (e.g., IL-6 and TNF-α), increased oxidative stress, and reduced immune cell activity, including that of natural killer (NK) cells and CD4+ lymphocytes. Melatonin regulates immune pathways, including NF-κB signaling. It a

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A, Tavartkiladze. "The Role of Melatonin and Matrix Metalloproteinases in Breast Cancer Pathogenesis: A Comprehensive Review." Advances in Pharmacology & Clinical Trials 9, no. 3 (2024): 1–11. http://dx.doi.org/10.23880/apct-16000240.

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Background: Breast cancer is a heterogeneous disease with molecular subtypes including Triple Negative Breast Cancer (TNBC), HER2/neu-positive, Luminal Type A, and Luminal Type B, each with unique clinical behaviors and therapeutic responses. This study investigates the role of melatonin, matrix metalloproteinases (MMPs), pro-inflammatory cytokines (IL6 and TNF-alpha), and lactate dehydrogenase (LDH) isoenzymes in breast cancer pathogenesis. Methods: Over three years, 171 breast cancer patients were studied. Blood and urine samples were collected to measure melatonin, MMPs, IL-6, TNF-alpha, LD

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Talib, Dunya, and Rana. "Multifaceted Roles of Melatonin in Sleep Disorders." Wasit Journal for Pure sciences 3, no. 2 (2024): 207–20. http://dx.doi.org/10.31185/wjps.366.

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Hormone protein melatonin helps regulate the sleep–wake cycle or circadian rhythm, making it a critical substance in sleep regulation. Melatonin synthesis mainly occurs in the epiphysis of the pineal gland, although extra-pineal melatonin has been observed in other sites of the body, such as salivary glands, the gastrointestinal tract, the placenta and breast milk. Over the years, research into melatonin has shown that it has multiple roles in sleep disorders, revealing its mechanisms of action, clinical implications and therapeutic performance. In this paper, we review recent findings on the

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Reiter, Russel J., Dun Xian Tan, and Annia Galano. "Melatonin: Exceeding Expectations." Physiology 29, no. 5 (2014): 325–33. http://dx.doi.org/10.1152/physiol.00011.2014.

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Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.

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Doghbri, Lamia, Melissa Carvajal-Serna, Moufida Atigui, et al. "Melatonin in Male Dromedary Camel (Camelus dromedarius) Seminal Plasma and Its Specific MT1 and MT2 Receptors on Sperm Membranes." Animals 15, no. 1 (2025): 83. https://doi.org/10.3390/ani15010083.

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Camels (Camelus dromedarius) are seasonal short-day breeders, regulated by photoperiod and melatonin secretion. However, no studies have explored melatonin levels in camel seminal plasma or their relationship with testosterone, age, or climatic factors, nor is it known whether melatonin receptors exist in camel spermatozoa to respond to seminal melatonin. This study aimed to analyze melatonin levels in camel seminal plasma and its specific receptors in spermatozoa. Semen samples were obtained from November to March (breeding season). Testosterone and melatonin levels were measured in seminal p

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WU, CHING‐SHYI, SEW‐FEN LEU, HSI‐YUAN YANG, and BU‐MIIN HUANG. "Melatonin Inhibits the Expression of Steroidogenic Acute Regulatory Protein and Steroidogenesis in MA‐10 Cells." Journal of Andrology 22, no. 2 (2001): 245–54. http://dx.doi.org/10.1002/j.1939-4640.2001.tb02177.x.

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ABSTRACT: The effects of melatonin on steroidogenesis and steroidogenic acute regulatory (StAR) protein expression were investigated in MA‐10 mouse Leydig tumor cells. MA‐10 cells were treated with human chorionic gonadotropin/cyclic adenosine monophosphate (hCG/cAMP) analogue alone or with hCG/cAMP analogue plus melatonin in different dosages (0.1 nM to 10 μM). Steroid production and the expression of StAR protein were measured. Melatonin directly inhibited hCG‐ or dbcAMP‐stimulated progesterone production in MA‐10 cells within 3 hours. The inhibitory effects of melatonin on hCG‐ or dbcAMP‐st

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Maharaj, Deepa S., Beverley D. Glass, and Santy Daya. "Melatonin: New Places in Therapy." Bioscience Reports 27, no. 6 (2007): 299–320. http://dx.doi.org/10.1007/s10540-007-9052-1.

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The fact that the full extent of the function of the pineal gland has not yet been elucidated, has stimulated melatonin research worldwide. This review introduces melatonin's mechanism of action, direct and indirect antioxidant actions as well as the antioxidant properties of its metabolites, 6-hydroxymelatonin (6-OHM) and N-acetyl-N-formyl-5-methoxykynurenamine (AFMK). At present the mechanism of action is proposed to be receptor-, protein- and nonprotein-mediated. From its popular role in the treatment of jetlag, melatonin is now implicated in the reduction of oxidative stess, both as a free

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Liu, Lifeng, Ying Xu, Russel J. Reiter, et al. "Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells." Cellular Physiology and Biochemistry 39, no. 6 (2016): 2297–307. http://dx.doi.org/10.1159/000447922.

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Background: In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive. Mitogen-activated protein kinase (MAPK) and Akt signaling pathways play key roles in the anticancer effects of melatonin. Aims: The present study investigated whether MAPK and Akt signaling pathways are involved in melatonin's antiproliferative actions on the human MG-63 osteosarcoma cells. Methods/Results: Western blot analysis confirmed that melatonin significantly inhibited phosphorylation of ERK1/2 but not p38, JNK, or Akt. The expressi

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Zhao, Shisu, Yanjun Dong, Yuanyuan Li, Zixu Wang, Yaoxing Chen, and Yulan Dong. "Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A." International Journal of Molecular Sciences 25, no. 2 (2024): 733. http://dx.doi.org/10.3390/ijms25020733.

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Pregnancy is a highly intricate and delicate process, where inflammation during early stages may lead to pregnancy loss or defective implantation. Melatonin, primarily produced by the pineal gland, exerts several pharmacological effects. N6-methyladenosine (m6A) is the most prevalent mRNA modification in eukaryotes. This study aimed to investigate the association between melatonin and m6A during pregnancy and elucidate the underlying protective mechanism of melatonin. Melatonin was found to alleviate lipopolysaccharide (LPS)-induced reductions in the number of implantation sites. Additionally,

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Di, Hongmei, Chenlu Zhang, Aolian Zhou, et al. "Transcriptome Analysis Reveals the Mechanism by Which Exogenous Melatonin Treatment Delays Leaf Senescence of Postharvest Chinese Kale (Brassica oleracea var. alboglabra)." International Journal of Molecular Sciences 25, no. 4 (2024): 2250. http://dx.doi.org/10.3390/ijms25042250.

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Melatonin, a pleiotropic small molecule, is employed in horticultural crops to delay senescence and preserve postharvest quality. In this study, 100 µM melatonin treatment delayed a decline in the color difference index h* and a*, maintaining the content of chlorophyll and carotenoids, thereby delaying the yellowing and senescence of Chinese kale. Transcriptome analysis unequivocally validates melatonin’s efficacy in delaying leaf senescence in postharvest Chinese kale stored at 20 °C. Following a three-day storage period, the melatonin treatment group exhibited 1637 differentially expressed g

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Cook, Jonathan S., and Chester A. Ray. "Melatonin attenuates the vestibulosympathetic but not vestibulocollic reflexes in humans: selective impairment of the utricles." Journal of Applied Physiology 109, no. 6 (2010): 1697–701. http://dx.doi.org/10.1152/japplphysiol.00698.2010.

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Melatonin has been reported to decrease nerve activity of medial vestibular nuclei in the rat and is associated with attenuated muscle sympathetic nerve activity (MSNA) responses to baroreceptor unloading in humans. The purpose of this study was to determine if melatonin alters the vestibulosympathetic reflex (VSR) and vestibulocollic reflex (VCR) in humans. In study 1, MSNA, arterial blood pressure, and heart rate were measured in 12 healthy subjects (28 ± 1 yr; 6 men, 6 women) during head-down rotation (HDR) before and 45 min after ingestion of either melatonin (3 mg) or placebo (sucrose). S

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Lütfullah BAŞLAK, Özlem ÜZAL, and Fikret YAŞAR. "Üşüme Stresi Altında Hıyar (Cucumis sativus L.) Fidelerinin Bazı Morfolojik Karakterleri Üzerine Melatonin Uygulamalarının Etkisi." ISPEC Journal of Agricultural Sciences 5, no. 2 (2021): 350–61. http://dx.doi.org/10.46291/ispecjasvol5iss2pp350-361.

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Beith F1 hıyar çeşidinin kullanıldığı araştırmada; üşümenin ve yapraktan uygulanan melatoninin fidelerin bazı morfolojik karakterleri üzerine etkileri araştırılmaya çalışılmıştır. 3-4 gerçek yapraklı iken üşüme uygulanan fidelere 0, 1, 10, 20, 30 ve 40 μM melatonin içeren saf (distile) su bitkilerin yapraklarına püskürtülmüştür. Melatonin uygulamasından 1 tam gün sonra bitkilerin yarısı iklim dolabında 15 gün süre ile üşüme stresine maruz bırakılmış, diğer yarısı ise iklim odasında normal koşullarda (25/20 °C aydınlık/karanlık) tutulmuştur. Üşüme stresine maruz kalan bitkiler 15 gün süreyle 5±

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Williams, Wynford R. "Dampening of neurotransmitter action: molecular similarity within the melatonin structure." Endocrine Regulations 52, no. 4 (2018): 199–207. http://dx.doi.org/10.2478/enr-2018-0025.

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AbstractObjectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides. Melatonin’s interaction with other G-protein regulated receptors, including those of serotonin, is unclear. This study explores the potential for the interaction of melatonin with nucleotide and receptor ligand structures. Methods. The study uses a computational program to investigate relative molecular similarity by the comparative superimposition and quantitative fitting of molecular structures to adeni

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Parua, Suparna, Gargi Roy Choudhury, Soumita Bhattacharya, et al. "Melatonin in Female Fertility: Multifaceted Role From Reproductive Physiology to Therapeutic Potential in Polycystic Ovary Syndrome, Endometriosis, and Ovarian Failure." Chronobiology in Medicine 6, no. 4 (2024): 145–62. https://doi.org/10.33069/cim.2024.0022.

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Melatonin, synthesized by the pineal gland, plays a pivotal role in female reproductive physiology. In addition to its established function in regulating circadian rhythms, melatonin influences critical reproductive processes, such as ovulation, menstrual cycle regulation, and fertility. Recent studies underscore melatonin’s regulatory effects on the hypothalamic-pituitary-gonadal axis, influencing the secretion of gonadotropins, including follicle-stimulating hormone and luteinizing hormone. Furthermore, melatonin has been implicated in the pathophysiology of reproductive disorders, such as p

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Alonso-Vale, Maria Isabel Cardoso, Sandra Andreotti, Sidney Barnabé Peres, et al. "Melatonin enhances leptin expression by rat adipocytes in the presence of insulin." American Journal of Physiology-Endocrinology and Metabolism 288, no. 4 (2005): E805—E812. http://dx.doi.org/10.1152/ajpendo.00478.2004.

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Leptin and melatonin play an important role in the regulation of body mass and energy balance. Both hormones show a circadian rhythm, with increasing values at night. In addition, melatonin receptors were recently described in adipocytes, where leptin is synthesized. Here, we investigated the influence of melatonin and its interaction with insulin and dexamethasone on leptin expression. Isolated rat adipocytes were incubated with melatonin (1 nM) alone or in combination with insulin (5 nM) and/or dexamethasone (7 nM) for 6 h. Melatonin or insulin alone did not affect leptin expression, but tog

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Bolotskikh, Vyacheslav, Ekaterina Novitskaya, Victoria Polyakova, and Egor Marin. "Melatonin levels and fetal growth restriction: Clinical insights and analytical approaches." Vestnik of Saint Petersburg University. Medicine 19, no. 2 (2024): 128–39. http://dx.doi.org/10.21638/spbu11.2024.203.

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Fetal growth restriction is a prevalent complication of pregnancy. Fetal growth restriction entails the pathological restriction of fetal growth, leading to heightened perinatal risks. Placental histopathology in fetal growth restriction typically involves incomplete invasion and transformation of spiral arteries, as well as impaired uteroplacental blood flow. Often, fetal growth restriction is comorbid with preeclampsia. Several theories propose the beneficial role of melatonin in reducing fetal growth restriction and preeclampsia. Studies suggest that melatonin may enhance neoangiogenesis an

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Tang, Kuo-Shu, Chun-Yi Ho, Chien-Ning Hsu, and You-Lin Tain. "Melatonin and Kidney Health: From Fetal Stage to Later Life." International Journal of Molecular Sciences 24, no. 9 (2023): 8105. http://dx.doi.org/10.3390/ijms24098105.

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Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models doc

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Dydyk, Martyna, Jakub Wójcik, Ewa Błaszczak, et al. "Therapeutic Potential of Melatonin: Multifaceted Applications in Muscle Health, Metabolic Disorders and Cardiovascular Disease." Quality in Sport 31 (November 12, 2024): 55921. http://dx.doi.org/10.12775/qs.2024.31.55921.

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Melatonin, a hormone primarily synthesized by the pineal gland, is traditionally associated with the regulation of circadian rhythms. However, recent research has unveiled its broad spectrum of biological effects, positioning it as a valuable therapeutic agent in diverse health contexts. Known for its potent antioxidant and anti-inflammatory properties, melatonin plays a crucial role in maintaining homeostasis and protecting cellular integrity. This review explores melatonin’s therapeutic applications across multiple medical domains, including muscle health, metabolic disorders, chronic pain m

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Reiter, Russel J., Dun-Xian Tan, Juan C. Mayo, Rosa M. Sainz, Josefa Leon, and Zbigniew Czarnocki. "Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans." Acta Biochimica Polonica 50, no. 4 (2003): 1129–46. http://dx.doi.org/10.18388/abp.2003_3637.

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This brief resume enumerates the multiple actions of melatonin as an antioxidant. This indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other organs. Additionally, however, it is found in invertebrates, bacteria, unicellular organisms as well as in plants, all of which do not have a pineal gland. Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical gener

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Yan, Manwen, Mingyan Li, Zhuoying Ding, Fei Qiao, and Xuefei Jiang. "Plant Hormone Signals Mediate Melatonin Synthesis to Enhance Osmotic Stress Tolerance in Watermelon Cells." Horticulturae 9, no. 8 (2023): 927. http://dx.doi.org/10.3390/horticulturae9080927.

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Melatonin, a multifunctional signaling molecule, has been shown to play a significant role in response to abiotic stress. Several species have been reported to unveil melatonin’s effect on osmotic stress; however, the signal transduction mechanism of phytohormone-mediated melatonin biosynthesis in plant species remains unclear. In this study, although plants can biosynthesize melatonin, the exogenous application of melatonin to watermelon cells can improve cell growth in response to osmotic stress by regulating the antioxidant machinery of cells. Regarding the melatonin synthesis pathway, ClOM

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Ran, Yuanyuan, Lin Ye, Zitong Ding, et al. "Melatonin Protects Against Ischemic Brain Injury by Modulating PI3K/AKT Signaling Pathway via Suppression of PTEN Activity." ASN Neuro 13 (January 2021): 175909142110228. http://dx.doi.org/10.1177/17590914211022888.

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Stroke is one of the leading causes of death and disability worldwide with limited therapeutic options. Melatonin can attenuate ischemic brain damage with improved functional outcomes. However, the cellular mechanisms of melatonin-driven neuroprotection against post-stroke neuronal death remain unknown. Here, distal middle cerebral artery occlusion (dMCAO) was performed in C57BL/6j mice to develop an ischemic stroke in vivo model. Melatonin was injected intraperitoneally immediately after ischemia, and 24 and 48 hours later. Melatonin treatment, with 5 to 20 mg/kg, elicited a dose-dependent de

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Hardeland, Ruediger. "Melatonin and retinoid orphan receptors: Demand for new interpretations after their exclusion as nuclear melatonin receptors." Melatonin Research 1, no. 1 (2018): 78–93. http://dx.doi.org/10.32794/mr11250005.

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The demonstrated incapability of the retinoic acid receptor-related orphan receptor-α (RORα) to bind melatonin inevitably requires consequences for interpreting numerous reports on actions of this protein as far as it was believed to be a nuclear melatonin receptor. While the synthetic compound CGP 52608 is, in fact, a ligand of RORα, effects obtained with this molecule can no longer be attributed to melatonin. Moreover, the sometimes assumed interplay between melatonin membrane receptors and RORα as nuclear receptors has to be dropped. Conclusions on melatonin’s actions via RORα that were bas

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Bier, Ariel, Rawan Khashab, Yehonatan Sharabi, Ehud Grossman, and Avshalom Leibowitz. "Melatonin Prevents T Lymphocyte Infiltration to the Kidneys of Hypertensive Rats, Induced by a High-Salt Diet, by Preventing the Expression of CXCR3 Ligand Chemokines." Nutrients 13, no. 10 (2021): 3577. http://dx.doi.org/10.3390/nu13103577.

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In a previous study, we demonstrated that melatonin prevents kidney damage in a salt-induced hypertension model by decreasing oxidative stress. We hypothesized that this effect involves melatonin’s immunomodulatory properties. In vivo Study-Dahl salt-sensitive (DSS) rats were fed normal chow, a high-salt diet (HSD), or a HSD and melatonin (30 mg/kg/day) in their water for eight weeks. Kidneys were harvested for immediate lymphocyte isolation and characterization by Flow cytometry (CD3+CD4+ and CD3+CD8+) and for lymphocyte chemoattractant (mainly CXCL chemokines) gene expression studies. In vit

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Bier, Ariel, Rawan Khashab, Yehonatan Sharabi, Ehud Grossman, and Avshalom Leibowitz. "Melatonin Prevents T Lymphocyte Infiltration to the Kidneys of Hypertensive Rats, Induced by a High-Salt Diet, by Preventing the Expression of CXCR3 Ligand Chemokines." Nutrients 13, no. 10 (2021): 3577. http://dx.doi.org/10.3390/nu13103577.

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In a previous study, we demonstrated that melatonin prevents kidney damage in a salt-induced hypertension model by decreasing oxidative stress. We hypothesized that this effect involves melatonin’s immunomodulatory properties. In vivo Study-Dahl salt-sensitive (DSS) rats were fed normal chow, a high-salt diet (HSD), or a HSD and melatonin (30 mg/kg/day) in their water for eight weeks. Kidneys were harvested for immediate lymphocyte isolation and characterization by Flow cytometry (CD3+CD4+ and CD3+CD8+) and for lymphocyte chemoattractant (mainly CXCL chemokines) gene expression studies. In vit

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Anderson, George, Cathy Vaillancourt, Michael Maes, and Russel J. Reiter. "Breast Feeding and Melatonin: Implications for Improving Perinatal Health." Journal of Breastfeeding Biology 1, no. 1 (2016): 8–20. http://dx.doi.org/10.14302/issn.2644-0105.jbfb-16-1121.

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The biological underpinnings that drive the plethora of breastfeeding benefits over formula-feeding is an area of intense research, given the cognitive and emotional benefits as well as the offsetting of many childhood- and adult-onset medical conditions that breast-feeding provides. In this article, we review the research on the role of melatonin in driving some of these breastfeeding benefits. Melatonin is a powerful antioxidant, anti-inflammatory and antinociceptive as well as optimizing mitochondrial function. Melatonin is produced by the placenta and, upon parturition, maternal melatonin

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Gao, Qiang, Chi Zhang, Jiaxin Li, et al. "Melatonin Attenuates H2O2-Induced Oxidative Injury by Upregulating LncRNA NEAT1 in HT22 Hippocampal Cells." International Journal of Molecular Sciences 23, no. 21 (2022): 12891. http://dx.doi.org/10.3390/ijms232112891.

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More research is required to understand how melatonin protects neurons. The study aimed to find out if and how long non-coding RNA (lncRNA) contributes to melatonin’s ability to defend the hippocampus from H2O2-induced oxidative injury. LncRNAs related to oxidative injury were predicted by bioinformatics methods. Mouse hippocampus-derived neuronal HT22 cells were treated with H2O2 with or without melatonin. Viability and apoptosis were detected by Cell Counting Kit-8 and Hoechst33258. RNA and protein levels were measured by quantitative real-time PCR, Western blot, and immunofluorescence. Bioi

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Contreras-Correa, Zully E., Riley D. Messman, Rebecca M. Swanson, and Caleb O. Lemley. "Melatonin in Health and Disease: A Perspective for Livestock Production." Biomolecules 13, no. 3 (2023): 490. http://dx.doi.org/10.3390/biom13030490.

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Mounting evidence in the literature indicates an important role of endogenous and exogenous melatonin in driving physiological and molecular adaptations in livestock. Melatonin has been extensively studied in seasonally polyestrous animals whereby supplementation studies have been used to adjust circannual rhythms in herds of animals under abnormal photoperiodic conditions. Livestock undergo multiple metabolic and physiological adaptation processes throughout their production cycle which can result in decreased immune response leading to chronic illness, weight loss, or decreased production ef

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Reiter, Russel J., Sergio Rosales-Corral, and Ramaswamy Sharma. "Melatonin: Protection of the Intervertebral Disc." Melatonin Research 2, no. 3 (2019): 1–9. http://dx.doi.org/10.32794/mr11250028.

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Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies. The loss of work time as a result of this problem is massive. Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actio

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Mubarok, Syariful, Erni Suminar, Adzkia Husnul Abidat, Citra Ayu Setyawati, Erik Setiawan, and Adine Syabina Buswar. "Overview of Melatonin’s Impact on Postharvest Physiology and Quality of Fruits." Horticulturae 9, no. 5 (2023): 586. http://dx.doi.org/10.3390/horticulturae9050586.

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Fruits are important horticultural commodities because they provide nutrients that help human health. Fruits are mostly consumed as fresh products; however, there are challenges in retaining the freshness, such as the rapid ripening process that triggers fruit deterioration and reduces fruit quality and nutrient content. The postharvest quality of horticultural crops is affected by pre-and postharvest treatment. Most farmers use chemical compounds and fungicides to prevent postharvest damage; however, this results in health hazards and environmental pollution. Melatonin can be used for maintai

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Reiter, Russel J., Dun-xian Tan, M. Pilar Terron, Luis J. Flores, and Zbigniew Czarnocki. "Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions." Acta Biochimica Polonica 54, no. 1 (2007): 1–9. http://dx.doi.org/10.18388/abp.2007_3264.

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This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via mem

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