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Artykuły w czasopismach na temat "Médicaments – Environnement"
Lafortune, Denis. "Expliquer, dépister et traiter médicalement les troubles du comportement des enfants et des adolescents". Nouvelles pratiques sociales 19, nr 2 (17.07.2007): 62–75. http://dx.doi.org/10.7202/016051ar.
Pełny tekst źródłaDuffy, Darragh. "Milieu Intérieur : définir les limites d’une réponse immunitaire saine pour mieux comprendre la maladie". médecine/sciences 35, nr 4 (kwiecień 2019): 327–31. http://dx.doi.org/10.1051/medsci/2019069.
Pełny tekst źródłaKhettar, S., C. Cozon i R. Megard. "Prévenir les erreurs médicamenteuses : la simulation au service de la psychiatrie". European Psychiatry 30, S2 (listopad 2015): S158. http://dx.doi.org/10.1016/j.eurpsy.2015.09.319.
Pełny tekst źródłaDecambron, Adeline. "Prise en charge thérapeutique de l’arthrose chez le chat". Le Nouveau Praticien Vétérinaire canine & féline 19 (grudzień 2022): 32–38. http://dx.doi.org/10.1051/npvcafe/2023006.
Pełny tekst źródłaGardin, G., P. Scherer, P. Bonniaud, G. Reboux i L. Blanchon. "Suivi téléphonique du dispositif de conseil médical en environnement intérieur en Bourgogne : impact positif sur la consommation de médicaments et l’adaptation du traitement". Revue Française d'Allergologie 53, nr 3 (kwiecień 2013): 357. http://dx.doi.org/10.1016/j.reval.2013.02.078.
Pełny tekst źródłaBlanchon, L., M. Bochaton, P. Scherer, I. Sullerot, G. Reboux, P. Bonniaud i G. Gardin. "Évaluation prospective du Conseil médical en environnement intérieur en Bourgogne auprès de 546 patients : réduction significative de la consommation de médicaments neuf mois après la visite". Revue Française d'Allergologie 54, nr 3 (kwiecień 2014): 246. http://dx.doi.org/10.1016/j.reval.2014.02.071.
Pełny tekst źródłaMoreau Defarges, Thierry. "Le médicament non utilisé, un enjeu sanitaire et environnemental maîtrisé". Actualités Pharmaceutiques 59, nr 594 (marzec 2020): 24–26. http://dx.doi.org/10.1016/j.actpha.2020.01.008.
Pełny tekst źródłaNouguez, Étienne, Henri Bergeron, Patrick Castel i Hadrien Coutant. "L’Agence française du médicament après le scandale du Mediator". L'Année sociologique Vol. 74, nr 2 (30.06.2023): 327–57. http://dx.doi.org/10.3917/anso.232.0327.
Pełny tekst źródłaTiret, Laurence. "Gene-environment interaction: a central concept in multifactorial diseases". Proceedings of the Nutrition Society 61, nr 4 (listopad 2002): 457–63. http://dx.doi.org/10.1079/pns2002178.
Pełny tekst źródłaPetrie, David. "An emergency medical services controversy in Nova Scotia: What is expanded-scope EMS?" CJEM 2, nr 01 (styczeń 2000): 39–40. http://dx.doi.org/10.1017/s1481803500004462.
Pełny tekst źródłaRozprawy doktorskie na temat "Médicaments – Environnement"
Baronnet, Véronique. "Environnement économique industriel et règlementaire du médicament". Paris 5, 1993. http://www.theses.fr/1993PA05P035.
Pełny tekst źródłaLaurencé, Céline. "Analyse prédictive du devenir des médicaments dans l'environnement". Thesis, Paris Est, 2011. http://www.theses.fr/2011PEST1094.
Pełny tekst źródłaPharmaceuticals as well as personal care products are classified as emerging pollutants of increasing concern due to possible negative impacts on ecosystems. They are constantly introduced in sewage treatment plants either through excretion, or disposal by flushing of unused or expired medication, or directly within the sewage effluents of plants or hospitals. They end up in surface and ground waters and can even be found in drinking water. Many studies report on adverse effects on terrestrial and aquatic organisms. Pharmaceuticals have complex chemical structures capable of reacting in an aqueous medium under the action of chemical, biological or physical agents. Thus, the transformation products (TPs) gradually replace the parent drug in the environment. In addition these transformation products constitute markers of past or current presence of the drug in the environment. Faced with this problem, we believe it is necessary to synthesize the transformation products of the parent compounds to development their detection. The proposed method consists, firstly, to prepare the largest number of (TPs) of a particular drug using three complementary approaches : bioconversion, electro-Fenton and electrochemical oxidation. A second step is to identify the structures which are the most likely present in the environment. Expected advances are the development of a predictive methodology applicable to the study of any molecule involved in environmental risk
Marchand-Pilard, Marie. "Propositions d’évolutions de l’encadrement juridique des rejets de médicaments humains dans l’eau". Electronic Thesis or Diss., Paris 8, 2022. http://www.theses.fr/2022PA080009.
Pełny tekst źródłaHuman drugs are chemicals designed to last long enough to have the desired effects on the body while resisting unwanted alterations to avoid adverse effects. These properties, closely studied by European and national authorities, make it possible to guarantee safe, effective, and quality pharmaceuticals but, conversely, pose a challenge for their end of life. These molecules “go through” the human body by undergoing degrees of alteration that can range from complete elimination to an unchanged status, ending up in whole or in part in wastewater (via our excretions). Added to this are unused pharmaceuticals that are improperly disposed of, effluents from industrial drug production sites and healthcare establishments, and WWTP sewage sludge, which can also contains drugs. However, whether under the regulations specific to medicines or those intended for the management of water, waste or sewage sludge, neither France nor the EU have an appropriate regulatory framework to manage these emerging pollutants, which is reflected in the treatments implemented in the WWTPs. As a result, drug residues are found in all European [and global] waters, some of which have harmful effects on aquatic environments. This thesis thus seeks to give recommendations aimed at combating this pollution in the EU and in France without reducing essential access to medicines
Legendre, Claire. "Adaptation cellulaire et moléculaire des cellules d'hépatome humain HepaRG à un environnement hypoxique". Rennes 1, 2009. http://www.theses.fr/2009REN1S055.
Pełny tekst źródłaReduced oxygen level, or hypoxia, is frequently encountered in solid tumours and contributes to drug resistance. Hypoxia is also associated with invasive phenotype and correlated to poor prognosis and mortality. The role of hypoxia in hepatocellular carcinoma biology is not fully understood. Therefore, there is a need for developing in vitro models mimicking hypoxic conditions find within solid tumours using hepatic tumour cells. Highly differentiated human hepatoma HepaRG cells respond to hypoxia by a switch from aerobic to anaerobic glycolysis. Moreover, we showed that hypoxia also repressed drug-metabolizing enzymes expression. These repressions could therefore strongly compromise chemotherapy effectiveness on tumour cells within hypoxic environment. Furthermore, HepaRG cells cultured under hypoxic versus normoxic conditions might represent a new strategy to test different types of therapeutic molecules in order to predict their effectiveness
Arpin-Pont, Lauren. "Les produits pharmaceutiques et de soin personnel en milieu marin : prédiction des concentrations environnementales et étude des effets sur le métabolisme endogène d’organismes exposés". Electronic Thesis or Diss., Montpellier, 2015. http://www.theses.fr/2015MONTS172.
Pełny tekst źródłaThe last twenty years, the issue of PPCP contamination of the marine environment caused a growing concern among scientific community. PPCP enter the environment mainly through wastewater treatment plants (WTP), not able to remove completely these substances. The first objective of the thesis was to assess the current state of knowledge on the PPCP occurrence in the different compartments of the marine environment (seawater, sediments and organisms) through a literature review. The contamination of the marine environment is generally assessed by “one-time” measures in situ. However, such monitoring campaigns are time-consuming and costly. Some approaches based on the determination of the predicted environmental concentrations (PEC) could be applied alternatively or complementarily to in situ measures. The PEC calculation is the first step of environmental risk assessment (ERA), to assess the exposure of non target organisms to these substances. However, this estimation needs to be refined to be accurate, by integrating site-specific information. The second aim of the thesis was to propose refined PEC calculation methodologies of pharmaceuticals and their metabolites in a coastal zone using an adapted hydrodynamic model. Two model compounds were chosen, carbamazepine and venlafaxine. In order to assess the environmental risk of pharmaceuticals, it is needful to assess their effects on organisms. Nowadays, few ecotoxicological data are available on marine organisms, contrary to freshwater organisms. Regulatory concept of ERA is often based on a set of short term standard tests carried out at high concentrations. Other tests, implemented at lower organizational levels, are more sensitive to low exposure levels and are more relevant for the marine risk assessment. The last objective was to study the effects of diclofenac on PG production, based on its mode of action, on marine mussels exposed
Idder, Salima. "État de la contamination des eaux du département de la Dordogne par les résidus de médicaments". Electronic Thesis or Diss., Bordeaux 1, 2012. http://www.theses.fr/2012BOR14652.
Pełny tekst źródłaThe beginning of the 21th century saw a growing interest for pharmaceuticals in aquaticsystems. The development of new analytical technologies allowing detection and quantification ofcompounds at ultra-trace levels mostly contributed to this expansion. These technologicalimprovements allowed to evidence and quantify many xenobiotics in various aquaticcompartments. Since about fifteen years, research teams focused their attention to human orveterinary pharmaceuticals. These contaminants are among emerging pollutants and no regulationexists in Europe concerning their presence in the environment. The presence of few tenths ofpharmaceuticals has been demonstrated. Living organisms in aquatic bodies are thereforeexposed to mixtures of compounds certainly at low doses (often between few ng and fewhundreds of ng) but continuously and the effects of this exposure are few documented. Thecontamination of aquatic systems by pharmaceuticals is usually the sign of an importanturbanization and streams with strong domestic pressures are often chosen as sampling sites inscientific studies. Nevertheless, the data concerning rural areas are still scarce although theyrepresent four fifth of the French territory.This work aims to establish a current situation of water resources of a rural territory, theDordogne administrative department. The occurrence of 40 pharmaceuticals including lipidregulators, antibiotics, β-blockers, non-steroidal anti-inflammatories, anticancer drugs, etc inseveral streams has studied with a multi-residue analytical method involving an on-linepreconcentration, a chromatographic separation followed by tandem MS/MS detection. Themethod has been validated for surface waters according to COFRAC requirements.Many sites were sampled every month during one year (2011) on six major streams of theDordogne department. The various campaigns allowed identifying the main areas contaminatedby pharmaceuticals and some linear correlations with other parameters (ammonium ion,phosphorus, etc.) have been evidenced.Beside the results obtained over all the Dordogne department, a focus on the presence ofpharmaceuticals in Isle river, around Périgueux, the main urban area of Dordogne, was led. Thissurvey allowed characterizing the introduction ways of pharmaceuticals and better understandingthe impact of the city of Périgueux on the river Isle
Olvera, Vargas Hugo. "Study on the fate of pharmaceuticals in aqueous media : synthesis, characterization and detection of biotic and abiotic transformation products using electrochemical advanced oxidation processes and bioconversions". Electronic Thesis or Diss., Paris Est, 2014. http://www.theses.fr/2014PEST1179.
Pełny tekst źródłaThe present project contributes with valuable data for a better fundamental understanding on the fate of pharmaceutical residues in the environment, dealing with the main challenges concerning this increasingly worrying environmental issue. The used Electrochemical Advanced Oxidation Processes (EAOPs), electro-Fenton (EF) and anodic oxidation (AO), showed to be a very efficient alternative for the mineralization of acid solutions of the pharmaceuticals RNTD and FRSM, attaining almost complete mineralization of the drugs after 6h of electrolysis. A comparative study on the mineralization of RNTD solutions by EF and SPEF processes in a 2.5 L capacity pre-pilot flow plant demonstrates the higher oxidation capacity of SPEF, achieving very good mineralization rates, thus evidencing the potentiality of this technology at greater scale for the treatment of wastewaters containing pharmaceutical products. The application of an EF pre-treatment coupled with a biological process for the degradation of both drugs was conducted. EF pre-pretreatment was capable of enhancing the solution biodegradability envisaging a biological treatment, which efficiently removed the short-chain carboxylic acids that had been formerly generated during the pre-applied electrolysis. In this way, the combination of both processes was confirmed as a very promising technology for the treatment of pharmaceuticals-containing wastewater. Several transformation products (TPs) were detected and identified during the electrochemical oxidation of the studied drugs. Toxicity tests based on the bioluminescence of the marine bacteria V. fischeri. evidenced the toxicity some of these oxidation by-products, since the toxicity of the solution increased on the first stages of the electrolysis. However, the abatement of the toxicity in the final stages of the electrochemical treatments, demonstrated the effectiveness of these technologies for both the mineralization and detoxification of the RNTD and FRSM solutions. The use of the fungi Cunninghanella echinulate for the bioconversion of FRSM led to the formation of three main bio-transofrmation products: the previously identified saluamide and pyridinium, and the new detected keto-alcohol derivate. These TPs were generated by both, biological and electrochemical approches, evidencing their high probability to be found in environmental compartments as the most likely TPs of FRSM by different oxidation conditions. This study is thus presented as a very useful alternative for the assessment of the fate of pharmaceutical residues in the environment
Gbaguidi, Bénédicte. "Caractérisation structurale de LmrP, protéine membranaire associée à la résistance bactérienne aux antibiotiques, dans son environnement lipidique". Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210714.
Pełny tekst źródłaIdder, Salima. "État de la contamination des eaux du département de la Dordogne par les résidus de médicaments". Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14652/document.
Pełny tekst źródłaThe beginning of the 21th century saw a growing interest for pharmaceuticals in aquaticsystems. The development of new analytical technologies allowing detection and quantification ofcompounds at ultra-trace levels mostly contributed to this expansion. These technologicalimprovements allowed to evidence and quantify many xenobiotics in various aquaticcompartments. Since about fifteen years, research teams focused their attention to human orveterinary pharmaceuticals. These contaminants are among emerging pollutants and no regulationexists in Europe concerning their presence in the environment. The presence of few tenths ofpharmaceuticals has been demonstrated. Living organisms in aquatic bodies are thereforeexposed to mixtures of compounds certainly at low doses (often between few ng and fewhundreds of ng) but continuously and the effects of this exposure are few documented. Thecontamination of aquatic systems by pharmaceuticals is usually the sign of an importanturbanization and streams with strong domestic pressures are often chosen as sampling sites inscientific studies. Nevertheless, the data concerning rural areas are still scarce although theyrepresent four fifth of the French territory.This work aims to establish a current situation of water resources of a rural territory, theDordogne administrative department. The occurrence of 40 pharmaceuticals including lipidregulators, antibiotics, β-blockers, non-steroidal anti-inflammatories, anticancer drugs, etc inseveral streams has studied with a multi-residue analytical method involving an on-linepreconcentration, a chromatographic separation followed by tandem MS/MS detection. Themethod has been validated for surface waters according to COFRAC requirements.Many sites were sampled every month during one year (2011) on six major streams of theDordogne department. The various campaigns allowed identifying the main areas contaminatedby pharmaceuticals and some linear correlations with other parameters (ammonium ion,phosphorus, etc.) have been evidenced.Beside the results obtained over all the Dordogne department, a focus on the presence ofpharmaceuticals in Isle river, around Périgueux, the main urban area of Dordogne, was led. Thissurvey allowed characterizing the introduction ways of pharmaceuticals and better understandingthe impact of the city of Périgueux on the river Isle
Fahy, Lucine. "Etude des conséquences d’un environnement hypoxique sur le développement et la chimiorésistance des leucémies aiguës lymphoblastiques T (LAL-T)". Thesis, Sorbonne Paris Cité, 2019. https://theses.md.univ-paris-diderot.fr/FAHY_Lucine_2_complete_20190627.pdf.
Pełny tekst źródłaBackground: T cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disorder characterized by an increased proliferation of T lymphocyte precursors that are unable to complete their maturation. Treatments are effective in 90% of children T-ALL cases. However, children with relapse have a very poor prognosis. Resistance to chemotherapy is thus a major therapeutic challenge in the treatment of T-ALL that can be driven by interactions between leukemic cells and the microenvironment. Bone marrow microenvironment, a crucial site of propagation and maintenance of leukemia, is hypoxic with oxygen levels varying from 0.1 to 5%. As hypoxic solid tumors are more resistant to radiotherapy and chemotherapy, the aims of the study were to investigate to which extent oxygen levels impact on leukemia development and chemoresistance and to characterize the implicated molecular mechanisms. Methods: Mouse models and patients derived samples of T-ALL were cultured in low (1% and 3.5%) and high (21%) oxygen levels. Growth, apoptosis, cell cycle, metabolism and chemoresistance were measured as well as in vivo leukemia propagation using immune deficient mice as ways to define the impact of oxygen levels on T-ALL.Results: Results show that hypoxia inhibits the growth of T-ALL by slowing down cell cycle progression and decreasing metabolism, making them less sensitive to anti-leukemic drugs and preserving their ability to initiate leukemia in vivo after treatment. Knocking down (KD) HIF1α counteracted the effects observed in hypoxic T-ALL and restored their chemosensitivity. Interestingly activation of mTOR was diminished in hypoxic leukemic cells and HIF-1α KD restored mTOR activation in these low O2 conditions. Moreover, inhibiting mTOR in HIF1aKD T-ALL enhanced their chemoresistance, indicating a functional relationship between these two pathways.Conclusion: This work shows that hypoxic niches can play a protective role during the treatment of T-ALL through a HIF1α/mTOR molecular loop. Inhibition of HIF1α and/or activation of the mTOR pathway may help suppress the chemoresistance of T-ALL in hypoxic niches
Książki na temat "Médicaments – Environnement"
C, Millington A., i Townshend John, red. Biomass assessment. London: Earthscan, 2009.
Znajdź pełny tekst źródłaNuclear juggernaut: The transport of radioactive materials. London: Earthscan, 2009.
Znajdź pełny tekst źródłaRICHARD, Jason. Méditations : Trouvez la Technique Qui Convient à Votre but et à Votre Environnement Même Debout !: Retrouver le Sommeil, Perdez Votre Stress et Votre Anxiété Sans Médicaments ! Independently Published, 2020.
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