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Collaveri, Jean-Pierre. "Etude des timbres transdermiques : évaluation d'une formulation adaptée à un principe actif x". Paris 5, 1990. http://www.theses.fr/1990PA05P051.
Pełny tekst źródłaTrichard, Laury. "Billes à base de cyclodextrines et d'huile : étude du mécanisme de formation et évaluation du potentiel en formulation et en thérapeutique". Paris 11, 2007. http://www.theses.fr/2007PA114810.
Pełny tekst źródłaA new dispersed system, consisting in semi-solid “beads”, is produced from a mixture of natural cyclodextrins, water and oil (vegetable, mineral or silicone oils) employing a soft, simple and innovative process. Beads were characterised and their formation mechanism was investigated by various physicochemical techniques. Thus, we identified some of the key points involved in bead formation: formation of inclusion complexes between oil components and cyclodextrins, formation of an o/w emulsion and cyclodextrin crystallisation. We took then benefits from the high oil content of beads to encapsulate two lipophilic model drugs, i. E. Isotretinoin and adapalene. Encapsulation yields reached 90-100%. Finally, our in vitro and in vivo assays showed that beads are well tolerated and are able to release active ingredients as well by oral than topical route
Pereira, de Santana Davi. "Évaluation biopharmaceutique de différentes formulations galéniques de l'isotrétinoine en gel". Université Joseph Fourier (Grenoble), 1992. http://www.theses.fr/1992GRE18013.
Pełny tekst źródłaPakpayat, Assavarat Natthilda. "Formulation et évaluation de l'acide ascorbique dans des microémulsions et nanoémulsions à base d'alkylpolyglucosides". Montpellier 1, 2008. http://www.theses.fr/2008MON13502.
Pełny tekst źródłaGrangier, Jean-Louis. "Mise au point et évaluation de l'association entre le GRF 1-29 et les nanoparticules de polyalkylcyanoacrylate". Paris 11, 1991. http://www.theses.fr/1991PA114817.
Pełny tekst źródłaCesaro, Umberto. "Advanced instrumentation for smart monitoring and automatic diagnostics in industrial and health applications". Electronic Thesis or Diss., Amiens, 2020. http://www.theses.fr/2020AMIE0040.
Pełny tekst źródłaIn this thesis, the feasibility of a method to measure the quantity of drug administered transdermally by impedance spectroscopy is demonstrated. The thesis proves the relevance of the impedance measurement to assess the quantity of drug penetrated into the skin after transdermal administration. In particular, the measured quantity of drug depends linearly on the variation in amplitude of impedance normalized to the pretreated value. In this thesis, the feasibility of a method to measure the quantity of drug administered transdermally by impedance spectroscopy is demonstrated.This thesis is made up of several parts, briefly described below. The first chapter presents an overview of electrical impedance spectroscopy and its applications. The second chapter talks about transdermal administration. This chapter also shows the feasibility of a method to measure the amount of drug transported transdermally. Next, the Drug Under Skin Meter (DUSM), a general purpose bioimpedance device capable of determining the amount of drug transmitted transdermally, is proposed. In the thesis, the concept and physical design of the instrument, as well as details on its production and operation, are illustrated. In addition, the experimental results obtained are illustrated The results indicate that the quantity of drug delivered can be evaluated by reasonable metrological performance by a single measurement of the amplitude of the impedance at a single frequency. The prototyped device has been shown to be able to identify the amount of drug (ml) delivered to a test tissue, by measuring the impedance spectrum before and after administration. The volume of drug (ml) transported through the skin is evaluated by locally measuring the bioimpedance before and after childbirth. In therapeutic applications, the instrument can provide an inexpensive and clinically portable solution. Then, the metrological characterization, using the injection as reference subcutaneous transfer of a known volume of drug, is reported, in laboratory, in vitro on eggplants and ex vivo, on ear pigs. The results of resolution, short-term stability, interindividual tissue reproducibility, sensitivity, repeatability and linearity indicate remarkable scenarios of clinical applications for such a bioimpedance device. Chapter three shows how the DUSM could also be used to monitor insulin absorption: a transducer on a chip, to monitor insulin that is actually bio-available after administration in clinical diabetology, is proposed. Bioavailability after administration is assessed by monitoring the amount of insulin under the skin using a bioimpedance measurement. An individual model, specific to each person during each insulin injection is identified, characterized and validated, to manage the individual inter and intra differences. Ideas of concept, architecture and operation of the transducer, as well as details on its prototype, are illustrated. Then, metrological characterization and validation are reported in the laboratory, as well as in vitro on eggplants, using injection as a reference subcutaneous transfer of a known volume of insulin. The results of significant intra-individual reproducibility in vitro on eggplants indicate significant scenarios for assessing the bioavailability of insulin in clinical diabetology. As an important branch of this research, the possibility of studying failure conditions in industrial plants was explored in Chapter 4. Finally two collateral works developed during this study period are presented
Nicoli, Sara. "Administration dermique et transdermique des médicaments : deux cas d'étude". Paris 11, 2002. http://www.theses.fr/2002PA114804.
Pełny tekst źródłaBlanchon, Sylvène. "Méthodologie d'étude pharmacotéchnique pour l'élaboration de systèmes transdermiques : application à la progestérone et à un progestatif de synthèse". Paris 11, 1991. http://www.theses.fr/1991PA114801.
Pełny tekst źródłaIllel, Brigitte. "Contribution à l'étude de la pénétration cutanée des particules : mise au point de deux méthodes d'étude quantitative des voies de pénétration transépidermiques et transfolliculaires". Paris 11, 1990. http://www.theses.fr/1990PA114804.
Pełny tekst źródłaDenoyer, Laurence. "L'analgésie par voie transdermique". Paris 5, 1998. http://www.theses.fr/1998PA05P030.
Pełny tekst źródłaCarvalho, Bouton Malua de. "Modélisation de l'absorption percutanée ex vivo de l'œstradiol". Lyon 1, 1995. http://www.theses.fr/1995LYO1T094.
Pełny tekst źródłaMachet, Laurent. "Utilisation des ultrasons pour augmenter l'absorption percutanée : la phonophorèse". Tours, 1997. http://www.theses.fr/1997TOUR3308.
Pełny tekst źródłaAubin, Christel. "Dispositifs transdermiques : actualisation". Paris 5, 1998. http://www.theses.fr/1998PA05P109.
Pełny tekst źródłaClemessy, Martine. "Étude d'un système de diffusion transdermique par iontophorèse". Paris 11, 1992. http://www.theses.fr/1992PA114833.
Pełny tekst źródłaRona, Nathalie. "Production d'ampoules injectables : validation d'un filtre stérilisant". Paris 5, 1999. http://www.theses.fr/1999PA05P177.
Pełny tekst źródłaSoury, Delphine. "Conception et caractérisation d’un dispositif original pour l’administration cutanée : applications diagnostique et thérapeutique". Paris 11, 2006. http://www.theses.fr/2006PA114805.
Pełny tekst źródłaDBV Technologies has developed an original device for cutaneous administration of molecules: the Epatch® system. The active substance is adsorbed on to the device as a powder by electrostatic forces. The occlusion provided by the device allows water condensation under the patch and the subsequent dissolution. An E-patch® composed of particles of cow’s milk powder has been developed to diagnose cow’s milk proteins allergy. The concentration of proteins in the vicinity of cutaneous immune cells and the absence of systemic delivery of intact proteins indicate the efficacy and safety of the test. The origin of the inflammatory reaction observed under a positive patchtest has been studied with mice sensitized to cow’s milk and implicates both immediate and delayed allergic mechanisms. The therapeutic potential of the E-patch® has been evaluated with fentanyl. A systemic passage of this molecule provoked has been demonstrated
Pichon, Françoise. "Systèmes transdermiques thérapeutiques et anti-inflammatoires non stéroi͏̈diens par voie percutanée". Paris 5, 1993. http://www.theses.fr/1993PA05P052.
Pełny tekst źródłaDufaÿ, Amélie. "Conception et évaluation d'un vecteur ciblé de thérapie génique anticancéreuse destiné à la voie intraveineuse". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114818/document.
Pełny tekst źródłaIntravenous administration of therapeutic DNA faces many obstacles related to its degradability and its difficulty to penetrate into the cells due to its large size and its hydrophilicity. Lipoplexes conjugated with high molecular weight hyaluronic acid (HA) have been designed in order to deliver plasmid DNA inside cancer cells expressing the membrane receptor CD44, a key receptor in the development of tumors. The use of HA conjugated to the phospholipid DOPE (HA-DOPE) and of the GFP model plasmid lead to obtain lipoplexes around 250 nm, negatively charged, which efficiently protect the DNA against nucleases and slightly stimulate the C3 fraction of the complement system. In a cellular model expressing CD44, the optimal transfection was obtained by using lipids containing 10% of HA-DOPE complexed to DNA at a 2:1 ratio. Internalization of these lipoplexes is mediated by the caveolae pathway and involves the CD44 receptor. This formulation was applied to the delivery of a therapeutic gene encoding the estrogen receptor β (ERβ), which is a potential tumor suppressor. On an in vivo xenograft model of estrogen-dependent breast cancer cells expressing CD44, decrease of the tumor volume, as well as decrease of the Ki67 proliferation index, have shown the anticancer activity of the lipoplexes conjugated to HA following intravenous administration
Meloni, Marisa. "Microémulsions : contribution à l'étude de systèmes non ioniques comme vecteurs de principes actifs destinés à la voie percutanée". Paris 5, 1991. http://www.theses.fr/1991PA05P622.
Pełny tekst źródłaNguyen, Corinne. "Prise en charge des douleurs sévères à intenses : durogesic (R), premier antalgique majeur transdermique". Bordeaux 2, 2000. http://www.theses.fr/2000BOR2P070.
Pełny tekst źródłaBou, Karam-Moreau Marinette. "Mise au point et évaluation d'un système bioadhésif gélifiant au contact des muqueuses". Paris 11, 1993. http://www.theses.fr/1993PA114818.
Pełny tekst źródłaSoussan, Elodie. "Conception de vésicules catanioniques dérivées de sucre et étude de leur mécanisme de délivrance de principes actifs". Toulouse 3, 2007. http://thesesups.ups-tlse.fr/14/.
Pełny tekst źródłaThe present work focused on the development of new sugar-based catanionic systems able to spontaneously form vesicles in water in order to deliver drugs towards cells. To validate these systems for drug delivery, original investigation methods based on the physical properties of giant magnetoliposomes and the electric properties of cell membranes have proven that a membrane fusion phenomenon is implicated between catanionic vectors and cells. This mechanism of fusion allows vectorization of hydrophilic drugs, encapsulated inside vesicle aqueous compartment, directly towards cell cytoplasm. After fusion, the internalisation of a vesicle bilayer fraction unables the delivery of lipophilic molecules confined inside the vesicle membrane. Catanionic vesicles are thus a versatile system able to deliver drugs within cells whatever their hydrophilicities. This new vector system offers promising application in vectorisation
Vantrou, Marylène. "Contribution à l'étude de l'activité de l'acide clofibrique par voie percutanée chez l'homme hyperséborrhéique, sur la glande costo-vertébrale de hamster". Paris 11, 1988. http://www.theses.fr/1988PA114818.
Pełny tekst źródłaTolenado, Nathalie. "Administration des médicaments injectables à l'aide de poches de petit volume à l'hôpital : aspect économique, recommandations de bon usage". Paris 5, 1999. http://www.theses.fr/1999PA05P133.
Pełny tekst źródłaBinje, Bernard. "Analgésie par bloc axillaire continu dans les traumatismes graves de la main : auto-administration versus perfusion continue, étude prospective sur une population de 42 patients". Bordeaux 2, 1997. http://www.theses.fr/1997BOR23092.
Pełny tekst źródłaMatyas, Frédérique. "Intérêts d'une fabrication centralisée des antibiotiques injectables en hôpital pédiatrique". Paris 5, 1999. http://www.theses.fr/1999PA05P131.
Pełny tekst źródłaMassella, Daniele. "Preparation of biofunctional textiles by surface functionalization based on the nanoencapsulation technique". Thesis, Lille, 2020. http://www.theses.fr/2020LILUI077.
Pełny tekst źródłaThis study was performed in the frame of the SMD-Tex Joint Doctorate project. The doctoral research activities were carried out in three mobility periods at POLITO (Italy), Ensait (France), and University of Soochow (China). This work aims to propose novel approaches for the production of biofunctional textiles. These products consist of textile fabrics which underwent special finishing treatments to confer properties that display beneficial effects to the user's health.In the last decades, pharmaceutical research has been investigating novel and more effective tools to administer a drug to the patient. The scope of these studies is to provide effective therapeutic dosages over a long time, minimizing the number of required administrations and the possible side effects. In this context, the skin has been regarded as a potential route for the release of local and systemic drugs. Such an approach is simpler and less invasive compared to other routes. Therefore, several strategies have been developed to effectively deliver drugs across the skin barrier. Among them encapsulation technology allows the incorporation of the active substances inside nanoparticles (NPs) to i) protect the drug, ii) effectively deliver it through the skin iii) control the release over time.In the present work, drug-loaded NPs were produced by employing polycaprolactone (PCL) as shell material. The produced nanoparticles were then used to finish cotton fabrics producing biofunctional textiles to be employed as wearable drug delivery devices. The flash nanoprecipitation technique (FNP) was exploited for the nanocarrier production being identified as a simple, sustainable and efficient production process. The suitability of the FNP process to produce NPs to be used in the preparation of biofunctional textiles was investigated. The PCL nanoparticles were produced by loading three different drugs in the system i.e. caffeine, melatonin, and curcumin. Such drugs are indeed considered model drugs in terms of hydrophilicity level. The latter is a key property in determining the outcome of the encapsulation process and the dermal permeation.The FNP process was run by dissolving the polymer in an organic solvent and making the solution stream collide against an antisolvent stream in a micromixer, resulting in the polymer precipitation in the form of nanoparticles. The drugs were precipitated together with the polymer upon being added either to the solvent or the antisolvent stream. For each active substance, the experimental protocols and analytical methods were adjusted to better investigated the drug-loaded NPs system. The effect of the formulation as well as the process parameters on the properties of the nanoparticles was investigated. The process was optimized to produce particles with a diameter lower than the one of skin pores. The amount of drug loaded in particles was investigated by loading capacity (LC) and encapsulation efficiency (EE). Furtherly, the NP formulations were characterized to obtain insights on their physical, chemical, and morphological properties by various analytical techniques.The particles were applied to the cotton fabric either by imbibition or impregnation methods. The effectiveness of the functionalization treatment was evaluated combining different analyses. The biofunctional properties were studied in terms of antioxidant activity, UV protection factors, and drug release. For the latter test, the Franz cell method was employed using either artificial and excised porcine skin membranes.The study showed that the FNP allows producing drug loaded PCL NPs for all the three investigated substances. The proposed finishing treatment allowed to effectively functionalize the fabric surface. The treated textiles allowed to effectively deliver the active principles to the skin with permeation profiles dependent on the drug properties. The nanoparticle finishing also imparted cotton antioxidant and UV protection properties
Guilmin, Caroline. "Evolution des prescriptions d'immunoglobulines intraveineuses polyvalentes à l'hôpital Saint-Louis de 1993 à 1997 : vers une maîtrise des indications ?" Paris 5, 1997. http://www.theses.fr/1997PA05P180.
Pełny tekst źródłaBize, Cécile. "Nouvelles associations catanioniques d'amphiphiles et de bolaamphiphiles dérivés de sucre". Toulouse 3, 2009. http://www.theses.fr/2009TOU30134.
Pełny tekst źródłaDuring the last decade numerous approaches have been developed in the aim of finding a safe and effective formulation for antihistamines dermal delivery. These Ph-D works, in collaboration with Pierre Fabre Dermo-Cosmetic industry, describe the design of original catanionic self-assemblies aiming to cutaneously deliver antihistamines. The prepration of these catanionic associations is based on an acid-base reaction between equimolar amounts of an acidic biocompatible sugar-based bolaamphiphile and a basic antihistamine drug. The bioactive catanionic associations obtained are able to self-organize in aqueous solution into supramolecular structures as vesicles and micelles. This original aggregation behaviour is exploited in order to elaborate new formulations providing to the drug solubilsation in aqueous media, a controlled release and a protection against UV damages of the antihistamine
Hoël, Antonin. "Conception et analyse d'un microsystème pour l'injection transdermique". Phd thesis, École normale supérieure de Cachan - ENS Cachan, 2007. http://tel.archives-ouvertes.fr/tel-00463096.
Pełny tekst źródłaNoquero, Philippe. "Formulation d'un système transdermique à base d'hydrogel utilisant comme principe actif un dérivé nitré". Toulouse 3, 1994. http://www.theses.fr/1994TOU32006.
Pełny tekst źródłaTeutonico, Donato. "Conception et évaluation de patches mucoadhésifs en vue d'optimiser l'administration orale des principes actifs mal absorbés". Institut Galien Paris-Saclay (Châtenay-Malabry, Hauts-de-Seine ; 1998-....), 2010. http://www.theses.fr/2010PA114845.
Pełny tekst źródłaThe oral route presents different advantages for the drug administration , but it presents multiple barriers that limit the bioavailability of peptides, proteins and other easily degraded molecules. This work, realized at the UMR CNRS 8612, consisted in the evaluation of a new approach, the gastrointestinal mucoadhesive patches, to the intestinal delivery of these drugs. These patch system in fact offer the possibility to reduce the drug degradation and increase the drug flow with a consequent increase of the drug absorption. The patches formulation that was realized in this thesis showed ex vivo and in vivo an increase of leuprolide absorption, a peptidic drug chosen as case study, compared with a control solution. This absorption enhancement was related to both the drug protection from degradation and the increase of the flow at the absorption interface. In order to describe in a more quantitative manner the absorption profiles obtained, a kinetic model was derived combining together the degradation ans the absorption occurring at the intestinal interface. Globally the pharmacokinetical results obtained ex vivo and in vivo demonstrated the importance of the patches geometry on the absorption and also that in order to have an optimal absorption it is necessary to assure the intestinal adhesion of the patches
Passot, Guillaume. "Évaluation du Bevacizumab par voie intra-péritonéale en association à une chirurgie de cytoréduction dans le traitement des carcinoses péritonéales d'origine non gynécologique". Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10346.
Pełny tekst źródłaAdvances in systemic chemotherapy permitted revolution in the management of peritoneal carcinomatosis with the development of cytoreductive surgery. The combination of cytoreductive surgery with systemic and intraperitoneal chemotherapy offer to selected patients a hope of cure and is considered as the treatment of choice for most carcinomatosis of non-gynecological origin. All carcinomatosis and all patients are different and numerous studies tried to determine factors for selecting patients eligible for such treatment. The mains prognostic factor for curative treatment is the ability to perform a complete cytoreduction. Despite these advances in the treatment and selection of patients, the results are still insufficient and few patients have resectable disease accessible to a cure. The development of biotherapies including anti -VEGF provides a new way of research. Bevacizumab, anti - VEGF antibody, showed significant efficacy in the treatment of metastatic diseases. It increases the efficiency of treatment by systemic chemotherapy. VEGF appears to have an important role in the development and aggressiveness of peritoneal carcinomatosis. To increase the effectiveness of curative treatment of peritoneal carcinomatosis, the combination of bevacizumab to the current standard treatment can be proposed. The bevacizumab administered intravenously may increase morbidity prohibiting its association with major abdominal surgery already burdened with significant morbidity. The hypothesis of this work is that the intraperitoneal administration of bevacizumab may increase resectability and survival of patients with peritoneal carcinomatosis of non- gynecologic origin and limit the morbidity. The aim is through clinical and experimental studies to evaluate the feasibility and the efficacy of treatment with intraperitoneal bevacizumab in combination with standard surgical treatment of peritoneal surface malignancy
Hamoudi, Mounira Cherifa. "Évaluation d'une forme galénique à base d'alpha cyclodextrine et d'huile végétale pour l'administration par voie orale de molécules actives peu solubles dans l'eau". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114826/document.
Pełny tekst źródłaThe general aim of this thesis was the study of the potential of beads, made of α-cyclodextrin and soybean oil, for the oral delivery of poorly water soluble drugs. We have first verified that it was possible to encapsulate in beads, active molecules (progesterone and indomethacin), other than retinoid and diazepam, with a high drug loading and a satisfying yied. The study of the behaviour of freeze-dried naked beads, in terms of stability and drug release in simulated gastro-intestinal fluids, allowed to propose a mechanism for the release of the encapsulated drug, involving several steps: i) hydration of the freeze-dried beads, ii) dissolution of α-CD hydrophilic matrix, iii) release of oily droplets containing the active drug and then of the fraction of drug dissolved in oil, following a partition phenomenon, iiii) fragmentation of the weakened beads and at last the total release of oil. The presence of bile salts in the medium accelerates both the release and the dissolved amount, by weakening the beads and reducing the partition coefficient value of the active molecule between oil and digestive medium.We have shown in vitro as well as in vivo that it is possible to modulate the release of a model drug from the same initial formulation, according to the degree of organization of the system (dry emulsion, naked beads, coated beads obtained by an additional amount of α-cyclodextrine to the preformed naked beads). In vivo studies in rats have highlighted that dry emulsion behaves as a fast release formulation, the coated beads as a sustained release formulation and the naked beads as an intermediate one. Finally, the release of the encapsulated drug can also be modulated by modifying the drying method of the beads. Compared to freeze-drying, oven-drying modifies the properties of the beads by increasing their resistance in simulated gastro-intestinal fluids and sustaining the release of the encapsulated drug
Roussel, Laurène. "Modulateurs moléculaires de l'absorption cutanée : analyse de la structure-activité de tensioactifs et caractérisation du transport cutané". Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10103.
Pełny tekst źródłaDosage forms specially designed allow the topical administration of drugs or cosmetic active ingredients to obtain a local effect or a systemic action. Excipients, such as surfactants in micellar solutions, emulsions, microemulsions, nanoemulsions, nanostructures can influence the drug penetration and permeation. Understanding their effects on skin barrier is helpful in the choice of surfactant. The aim of this thesis was to study the effect of different surfactants (alkylpolyglucosides, lipoaminoacids, ethoxylated fatty alcohol and copolymers blocks) in aqueous solution on the skin barrier structure and function, using techniques like infrared Fourier transform, differential scanning calorimetry, transepidermal water loss measurement and transmission electron microscopy. The specific aim of this work focused on the ex vivo cutaneous absorption of three drugs showing different lipophilicity (caffeine, ketoprofen and progesterone) through animal skin co-treated by different surfactants. More specifically, the penetration of progesterone in the different skin layers has been studied due to its high lipophilicity limiting its permeation in the most hydrophilic layers (viable epidermis and dermis). At the outset, we showed that surfactants could provide not only an effect on lamellar organization of intercorneocyte lipids but also on the corneocytes into the stratum corneum (SC). Moreover, these different results allowed to define surfactant chemical structure increasing drug cutaneous absorption. Anionic surfactant with a C12 chain length increased significantly cutaneous permeation of hydrophilic drug and penetration of lipophilic drug into cutaneous tissue. Drug penetration is correlated with micelle size allowed its incorporation into SC intercorneocyte spaces. Finally, the value of its critical micellar concentration is a physico-chemical properties allowed to partially explain the surfactant effect on their cutaneous permeability
Pereau, Buffin Sophie. "Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses". Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1087.
Pełny tekst źródłaThe influenza virus infects the mucous membranes of the respiratory tract. An intranasal vaccine induces an immune response close to the one induced by the natural infection by blocking the virus directly at the site of infection and allows needle-free vaccination. In addition, vaccines based on Virus-like Particles (VLP) produced in cells represent an interesting alternative to the traditional egg-based vaccine. VLPs are non-replicative particles that mimic the virus. Studies on influenza VLPs have shown protection by the intranasal route without adding an adjuvant. During my thesis, a platform for the production of influenza VLPs composed of the hemagglutinin, the neuraminidase and the M1 matrix proteins was developed by transient transfection of mammalian cells. Immunizations of BALB/c mice showed that the purified and characterized type A and B VLPs were immunogenic at low doses by the intramuscular route. The intranasal administration of VLPs with the B subunit of cholera toxin as a mucosal adjuvant resulted in serum antibody levels comparable to those obtained by intramuscular immunization but also a strong IgA response in the mucosal secretions. In addition, VLP yield was found to be strain-dependent and linked to the HA and NA proteins on the surface of the particle. To overcome this problem, a quadrivalent vaccine based on two bivalent VLPs each expressing two different HAs and NAs at the surface was produced, demonstrating the flexibility of this platform
Shah, Shefaat Ullah. "Formulations polymériques pour l'administration par voie orale de vecteurs originaux d'oxyde nitique dans le traitement des maladies inflammatoires de l'intestin : mise au point et évaluation de la biodisponibilité". Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0126/document.
Pełny tekst źródłaThe aim of the thesis was to develop novel and stable NO-donors by linking S-nitrosoglutathione (GSNO) to a polymer backbone. In the first step, chitosan-GSH and alginate-GSH conjugates were prepared by a carbodiimide reaction and in the second step SNOC (S-nitrosoglutathione-oligosaccharide-chitosan) and SNA (S-nitrosoglutathione-alginate) were prepared by the nitrosation of both conjugates respectively. The amount of NO was determined by Griess and Saville methods. Stability and ex vivo experiments of SNOC and SNA were performed in an Ussing chamber through rat intestine. We obtained polymers with different amount of NO (i.e. 159 µmol of NO/g to 525 µmol of NO/g for SNOC; 174 µmol of NO/g to 468 µmol of NO/g for SNA) depending upon the procedure of nitrosation. SNOC was stable for at least 6h and SNA for at least 10h. Also, we aimed to develop spray dried microparticles of GSH and GSNO based on Eudragit® FS 30D polymer. The microparticles were characterized by scanning electron microscopy (SEM), X-ray diffraction (PXRD), infrared spectroscopy (FTIR) and in vitro release studies were performed in different pH conditions (pH 1.2, 3, 6, 6.8 and 7.4). The microparticles were negatively charged with mean particle size ranging from 5 to 7 µm. The formulation was stable and was resistant to acidic pH but showed rapid release in basic pH; hence, they can be used as colon specific drug delivery systems for the treatment of Crohn’s disease. We think that these formulations could be used in animal models in the treatment of Crohn’s disease
Coutable, Jocelyn. "Contribution à l'étude du passage percutané d'un inhibiteur calcique de la famille des phényl-dihydropyridines : développement et optimisation d'une forme topique". Paris 5, 1991. http://www.theses.fr/1991PA05P618.
Pełny tekst źródłaConsola, Sabrina. "Conception originale d'auto-assemblages catanioniques "amphiphile dérivé de sucre – anti-inflammatoire" : nouveaux systèmes bioactifs pour l'administration cutanée de médicament". Toulouse 3, 2005. http://www.theses.fr/2005TOU30283.
Pełny tekst źródłaThe cutaneous anti-inflammatory agents delivery is one of the main challenges in dermatological research. These Ph-D works, in collaboration with the Pierre Fabre Dermo-Cosmetic industry, describe the design of original catanionic self-assemblies aiming to cutaneously deliver anti-inflammatory drugs. The preparation of these catanionic assemblies is based on an acid-base reaction between equimolar amounts of an acidic anti-inflammatory drug and a basic and biocompatible sugar-derived surfactant. The surface active ion pairs obtained are able to self-associate, in aqueous solution, into supramolecular structures like vesicles. This original aggregation behaviour is exploited in order to elaborate bioactive formulations with improved therapeutic properties compared to the free drug. This new kind of formulation provides to the drug an enhanced anti-inflammatory activity, a controlled and sustained release through the skin and a protection against UV damages
Guhmann, Pauline. "Délivrance orale d'insuline par double encapsulation : développement et évaluation de l'efficacité et de la sécurité des systèmes entériques et nanoparticulaires". Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01071851.
Pełny tekst źródłaTalbi, Yassine. "Conception d'un patch transdermique intelligent pour le monitoring et l'aide à la prise de médicament". Thesis, Toulouse, INSA, 2018. http://www.theses.fr/2018ISAT0005/document.
Pełny tekst źródłaPersonalized monitoring is an emerging ambition for health technologies responding the needs of patients and healthcare professionals. In this regard, the purpose of this work is to propose a e-health care device offering active control and permanent actuating link able to control the amount of drug delivered. A first part presents our motivations related to the problems of the aging of the population, recalls the current approaches for the monitoring of the elderly and describes the need in the systems of actuations in particular for the aid to the taking of drugs. From these needs, a state of the art is proposed on the techniques for controlling the delivery of drugs. Experiments are carried out to demonstrate the efficiency of diffusion techniques controlling and improving the quantity delivered. The control of the administered dose is correlated to the integrated actuator via a control command. We present a modeling and a numerical simulation of the transdermal diffusion related to the results obtained during experiments on a Franz cell, and the transposition of the model on a planar structure. Different scenarios of electrical stimulations and shape factors have been conducted to obtain optimal administration profile. Finally, the last part is devoted to technological locks and to the design of the intelligent system which adapt the dose administered according to the needs of the patient. A prototype is made, integrating actuation functions, and data recovery from integrated sensors
Bourdon, Florence. "Développement de formes transdermiques à usage hospitalier, à partir de véhicules prêts à l’emploi, pour le traitement des nausées et vomissements chimio-induits". Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S052/document.
Pełny tekst źródłaDespite the high number of formulations available for a drug on the pharmaceutical market, it can arise that a patient needs a treatment for which none pharmaceutical form or dosage is available. In this case, pharmacy department of the hospital may have to prepare this form, in accordance with health agency.The goal of this work was to develop a semi-solid transdermic formulation from ready for use vehicle and containing three antiemetic drugs for the treatment of chemotherapy induced nausea and vomiting. Hence, ondansetron, dexamethasone and aprepitant have been formulated in five commercial vehicles of liposomal (PLO®, Lipovan®, Pentravan® and Pentravan Plus®) or phytosomal (Phytobase®) composition. After development of a formulation protocol, quality control was carried out on every finished preparation It focused on the evaluation of the content of active ingredients in formulations and their homogeneity. For this purpose a separation method using HPLC-UV and a method based on PLS-UV have been developed and validated according to the recommendations of the French Society of Pharmaceutical Science and Technology to assay the three antiemetics simultaneously.Two in vitro studies were then implemented on a Franz cell. The first, using cellulose acetate membranes, has shown that the PLO® and the Pentravan Plus® are the most efficient vehicles for releasing the three drugs formulated separately. The second one was performed to assess the permeation of the same drug through pig ears skin epidermis. It highlighted the performances of Pentravan Plus® as a vehicle for the simultaneous transdermal administration of ondansetron and dexamethasone. Nevertheless, as permeation of aprepitant is too poor to consider its transdermal administration, it has not been included in the final formulation. Different chemical enhancers were evaluated to improve the transcutaneous passage: tween 20 appeared to be as powerful as ethanol conventionally used for the incorporation of drugs in these vehicles
Guillet, Jean-François. "Nanotubes de carbone pour la délivrance transdermique électro-stimulée de substances biologiquement actives". Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30348/document.
Pełny tekst źródłaThe permeability of skin does not allow the passive diffusion across epidermis to reach blood vessels for large molecular weight molecules such as insulin or DNA plasmids. This is possible only for small molecules such as nicotine, for example. Alternative routes of transdermal delivery exist (thermal, electrical, mechanical) that avoid injections and improve the quality of life of patients suffering of diseases like diabetes. These methods known as "Transdermal Drug Delivery" (TDD) technologies, include for example electroporation, iontophoresis and micro needles. In particular, electropermeabilisation is known to temporarily increase the permeability of the skin, consequently allowing transdermal passage of molecules of high molecular weight. The aim of this work was to conceive and elaborate an innovative needle-free device for transdermal drug delivery, made of a nanocomposite material containing carbon nanotubes to improve both electrical and mechanical properties of the biocompatible polymer matrix. This nanocomposite device aims at permeabilising the skin and delivering drug molecules simultaneously when electrically stimulated. To reach this goal, we investigated different biocompatible polymers and shaping processes, finally demonstrating the feasibility of the fabrication of such a device. We have developed a bio-sourced and biocompatible nanocomposite hydrogel with an agarose matrix and containing double-walled carbon nanotubes, and characterized it in terms of microstructure, storage and release capacity, as well as electrical properties. In the general context of precaution in relation to the implementation of nanoparticles, and on the basis of previous work demonstrating the safety of nanotubes used when they are not in direct contact with cells, we have also demonstrated that there is no release of the nanotubes under extreme conditions of temperature (without electrostimulation) in an artificial sweat medium. Finally, we have demonstrated the feasibility of its first use as a TDD system using an ex vivo mouse skin model. These results provide good evidence that the use of double-walled carbon nanotubes makes possible the transdermal delivery of large molecules with a molecular weight similar to insulin with such a nanomaterial. This thesis was in co-direction, combining Materials Science (CIRIMAT) and Life Science (IPBS) in order to gather different skills, giving it a real interdisciplinary context. Moreover, this work was integrated into a larger project (CNRS, "Nano challenge"), also including Sociology and Law, focusing on diabetes. This has demonstrated the actual demand for such a device from both the medical doctors and the patients, but also directed our work towards a medical device thanks from the juridical point of view