Rozprawy doktorskie na temat „Medical Biotechnology”
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Malindi, Zaria. "Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology". Master's thesis, Faculty of Health Sciences, 2018. http://hdl.handle.net/11427/31064.
Pełny tekst źródłaJordaan, Donrich W. "Medical biotechnology law in South Africa : a human rights analysis of selected topics". Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/13868.
Pełny tekst źródłaIn this thesis I analyse the human rights dimensions of the South African law on four topical medical biotechnology subjects, namely human embryo research, the use of human gametes, autologous tem cell therapy, and private stem cell banking. In all four cases, my analyses give specific prominence to two research themes: first, human dignity as touchstone of the South African human rights regime, and secondly legal certainly. The analyses show that the legal rules governing three of the four selected medical biotechnology subjects are not aligned with the country's human rights regime.
Ramsin, Chelsea, Johanna Lidman, Frida Boström, Vendela Andersson, Sigrid Mack, Per Lindbom i Zad Elnaz Samadian. "Development of sensitive and rapid cancer diagnostic assyas". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412138.
Pełny tekst źródłaBrunet, Nicolas. "Study of a valorisation process for biomass industrial waste involving acid cooking and enzymatic hydrolysis". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278738.
Pełny tekst źródłaLignocellulosic biomassa har potential att bidra till kemikalier och biobränsletillförsel i framtidasamhällen, trots att lignocellulosa är en rekalcitrant struktur som måste behandlas i flera steg. Idagträmaterial som spånskivor bara används för energiåtervinning och värmeproduktion efter deraslivscykel. De kan därför användas som råvara för framställning av värdefulla molekyler.Fermenteringsprocesser behöver frisättningen av trä monosackarider genom förbehandlingsprocesseroch enzymatisk hydrolys. Studien fokuserar på potentialen för avfall från spånskivor för kemisk ochbiobränsleproduktion. Vi har jämfört sackarifiering mellan nativt trä och spånskivor genom simuleradångaxplosion och enzymatisk hydrolys, med en inblick i efterföljande fermentering av Saccharomycescerevisiae. Spånskivor bunden av urea-formaldehyd undersöktes, liksom vissa aspekter av spånskivorbundna med melamin-urea-formaldehyd. Förbehandlingen producerade högre koncentration av lignocellulosa nedbrytningsprodukter frånnativt trä jämfört med spånskivor. Bildningen av nedbrytningsprodukter från sockerarter - furfural och5-hydroxymethylfurfural - ökade med längre förbehandlingar. En väsentlig fraktion av limmet borttogsfrån spånskivorna, vilket ledde till jämförbara koncentrationer i fri urea, dess nedbrytningsprodukteroch formaldehyd mellan naturligt trä och spånskivor under enzymatisk hydrolys. Enzymatisk hydrolys med cellulaser och hemicellulaser avslöjade den kritiska rollen av förbehandlingför att förbättra utbytet, både i naturligt trä och i urea-formaldehyd spånskiva. Längre (20 minuter)ångexplosion vid 160° C resulterade i högre glukosutbytet (från 18,5% till 32,8% för naturligt trä ochfrån 15,6% till 37,4% för spånskivor). Förlängning av uppehållstiden före behandlingen till 35 minuterresulterade i mycket bättre glukosekstraktion för nativt trä (64,5%) men endast liten framsteg förspånskivan (41,1%). Detta resulterade i maximalt utbyte av 277 mg Glc/g biomassa och 184 mg Glc/ gbiomassa för nativt trä och spånskivor, respektive. Fermentering visade hög hämning från lignocellulosa nedbrytningsprodukter som inte analyserades iprojektet för både nativt trä och spånskällor för media. Etanol bildades under fermentering medreducerad produktivitet men ökade utbyten jämfört med kontrollprovet. Hämningen var så stark attingen skillnad kunde ges mellan naturligt trä och spånskivor. I denna situation kunde ingenhämningspotential för lim eller dess nedbrytningsprodukter bevisas.
Abuamra, Ola A. E. "Effect of IL-6 modulation on feeding behaviour and learning and memory in the ventral hippocampus". Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20507.
Pełny tekst źródłaOdén, Österbo Ina, Malin Åslund, Linnea Flinkfeldt, Josef Pelcman, Vilhelm Book i Joakim Lindström. "Hur hittas HIV? : Två metodförslag för koncentrationsmätning av virioner i blodplasma". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-323192.
Pełny tekst źródłaKoller, Daniela. "Processing of Optical Coherence Tomography Images : Filtering and Segmentation of Pathological Thyroid Tissue". Thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161988.
Pełny tekst źródłaJohansson, Hampus. "Nox2/4 inhibition in NB69 during ischemia/reperfusion : Inhibition of ROS-production using M4, M107, and M114". Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17941.
Pełny tekst źródłaRamachandraiah, Harisha. "Microfluidic based isolation of circulating tumor cells from whole blood for cancer diagnostics". Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-203889.
Pełny tekst źródłaQC 20170321
Odell-West, Amanda. "Should the medical exclusion within patent law be amended or removed?" Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606774.
Pełny tekst źródłaFolasire, Oladayo. "Comparing the caveolae mediated endocytosis of two DNA-chitosan polyplexes". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for fysikk, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-14200.
Pełny tekst źródłaWright, Alice Ann. "The Genomic Sequence and Annotation of Bacteriophage HK239". TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/208.
Pełny tekst źródłaFiorillo-Buonomano, Daniela. "Das Zustimmungserfordernis bei der Patentierung von biotechnologischen Erfindungen unter Verwendung menschlichen Materials". Bern Stämpfli, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=3013860&prov=M&dok_var=1&dok_ext=htm.
Pełny tekst źródłaTanikawa, Aline Aki [UNESP]. "Avaliação da resistência primária aos inibidores de integrase em pacientes soropositivos para o HIV-1". Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/88084.
Pełny tekst źródłaMinistério da Saúde
A falta de um kit otimizado para avaliação da resistência aos inibidores de integrase no Brasil conduziu à necessidade da padronização de uma técnica inhouse para o estudo de mutações no gene da integrase do HIV-1, possibilitando, assim, a avaliação da resistência a esta classe de antirretrovirais recentemente liberada no país. RNA viral plasmático foi utilizado como fonte para amplificação por RT- Nested PCR e sequencimento do gene da integrase do HIV-1 de 60 pacientes para análise do padrão de resistência, o qual foi avaliado utilizando o algoritmo proposto pela Universidade de Stanford. Cinquenta e quatro (90%) amostras obtiveram sucesso na amplificação e sequenciamento, sendo que destas dez foram amplificadas por protocolos alternativos que envolveram a utilização de enhancer, de enzimas com maior especificidade, RT-PCR one-step e alterações nas condições de ciclagem, o que possibilitou com sucesso o estudo da região de interesse e a análise de resistência. A metodologia in-house mostrou ser uma alternativa metodológica viável para avaliação da resistência aos inibidores de integrase, principalmente nos casos em que há falha terapêutica a esta nova classe de medicamento, uma vez que a técnica permite o estudo completo da região de interesse
The absence of an optimized kit to evaluate the resistance to integrase inhibitors in Brazil led to the necessity for standardization of an in-house technique to study the mutations in the HIV-1 integrase gene, thus enabling the evaluation of resistance to these novel antiretroviral agents recently released in the country. Plasma viral RNA was obtained from 60 patients and used as source for RT- Nested PCR amplification and automatic sequencing of the HIV-1 IN gene to analysis of the pattern of drug resistance, which was evaluated using the algorithm proposed by Stanford University. Fifty-four (90%) samples were successfully amplified and sequenced, and ten of these samples were amplified using alternative protocols involving the use of enhancers, enzymes with more specificity, RT-PCR one step and changes in the conditions of cycling, which allowed the successful study of the region of interest and analysis of resistance. The in-house methodology showed to be a viable alternative to assess resistance to integrase inhibitors, especially in cases when there is therapeutic failure to this new class of antiretroviral, since the technique allows the complete study of the region of interest
Persson, Anna. "Non-vitamin K dependent oral anticoagulants (NOACs) controls". Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148558.
Pełny tekst źródłaAndersson, Klara. "Characterization of nsP-specific nanobodies targeting Chikungunya and Semliki Forest Virus". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414971.
Pełny tekst źródłaFridh, Benjamin. "Mapping of spontaneous biological phosphorous removal in MBR-process". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278572.
Pełny tekst źródłaEn oväntad biologisk fosforrening (bio-P) i IVL Hammarby Sjöstadsverkets membranreaktorpilot undersöktes med tre distinkta metoder. Kvantifiering av det biologiska fosforupptaget undersöktes med fosforsläppstest (PRT). Validering av förekomsten av fosfatackumulerande organismer (PAO) via infärgning av polyfosfatgranuler med Neissers protokoll för infärgning med metylenblå. Ett nytt protokoll för kvantifiering av polyfosfatgranulkluster gav indikationer på relativ aktivitet av bio-P i reningsprocessens bioreaktorer. Bio-P aktiviteten som uppmättes med PRT visade på hög kapacitet av biologisk fosforackumulation. Vidare visades framgångsrikt att stresspåslag av PAO med etylendiamintetraättiksyra (EDTA) ökade fosfatsläppshastigheten och uttömningen av intracellulär poly-P. Slutligen undersöktes temperaturberoendet i PRT. En 16S rRNA metagenomikstudie gav 28 st prover redo att sekvensieras och analyseras. Projektet har framgångsrikt validerat och kvantifierat bio-P med en utvecklad metodologi som kan utgöra grunden för kommande studier vid reningsverket.
Tanikawa, Aline Aki. "Avaliação da resistência primária aos inibidores de integrase em pacientes soropositivos para o HIV-1 /". Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/88084.
Pełny tekst źródłaAbstract: The absence of an optimized kit to evaluate the resistance to integrase inhibitors in Brazil led to the necessity for standardization of an in-house technique to study the mutations in the HIV-1 integrase gene, thus enabling the evaluation of resistance to these novel antiretroviral agents recently released in the country. Plasma viral RNA was obtained from 60 patients and used as source for RT- Nested PCR amplification and automatic sequencing of the HIV-1 IN gene to analysis of the pattern of drug resistance, which was evaluated using the algorithm proposed by Stanford University. Fifty-four (90%) samples were successfully amplified and sequenced, and ten of these samples were amplified using alternative protocols involving the use of enhancers, enzymes with more specificity, RT-PCR one step and changes in the conditions of cycling, which allowed the successful study of the region of interest and analysis of resistance. The in-house methodology showed to be a viable alternative to assess resistance to integrase inhibitors, especially in cases when there is therapeutic failure to this new class of antiretroviral, since the technique allows the complete study of the region of interest
Orientador: Maria Inês de Moura Campos Pardini
Coorientador: Rejane Maria Tommasini Grotto
Banca: Paulo Inácio da Costa
Banca: João Manuel Grisi Candeias
Mestre
Lindén, Matilda. "Potentiellt cancerpreventiva effekter av Sulforafan : En litteraturstudie". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-87516.
Pełny tekst źródłaSulforaphane is an isothiocyanate that is described as having chemopreventative effects. The phytochemical is made available to humans by dietary consumption of cruciferous vegetables such as broccoli and kale. Cancer is a common disease, and in Sweden it is estimated that one in three will be diagnosed with cancer during their lifetime. This review study aims to summarize the effect of sulforaphane on human colon cancer cells, and seek evidence that consumption of cruciferous vegetables reduces the risk of developing colon cancer. Sulforaphane is considered chemopreventative in vitro through inhibition of histone deacetylas activity, induction of cell cycle arrest and apoptosis and through reduction of cell proliferation. It has also been shown to reduces expression of genes involved in angiogenesis.There is not enough evidence to confirm that dietary broccoli consumption, through its high content of sulforaphane, would be chemopreventative.
Lu, Andy. "Forensic analysis on wireless medical devices". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2541.
Pełny tekst źródłaChung, Chao-Chen. "Government, governance and the development of the innovation systems : the example of the Taiwanese biotechnology and related sectoral policies". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/government-governance-and-the-development-of-the-innovation-systems-the-example-of-the-taiwanese-biotechnology-and-related-sectoral-policies(504024b2-cb76-4624-a31b-3572e4a7fa57).html.
Pełny tekst źródłaRufatto, Luciane Corbellini. "Estudo bioguiado da Própolis Vermelha Brasileira visando à atividade antibacteriana". reponame:Repositório Institucional da UCS, 2016. https://repositorio.ucs.br/handle/11338/2156.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES.
Mehyeddine, Katya. "The Impact of Compressive and Cyclic Loading Frequency on Longitudinal Growth, Given a Constant Amplitude". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230806.
Pełny tekst źródłaForss, Elin. "Evaluation of OSTE-hybrid materials for acoustophoresis applications". Thesis, KTH, Medicinteknik och hälsosystem, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-277052.
Pełny tekst źródłaI detta projekt undersöktes ett nytt hybridmaterial för användning i applikationer inom akustofores. Akustofores kan användas till att manipulera partiklar inuti mikrofluidkkanaler genom att generera ståendevågor i kanalen med hjälpav ultraljud [1]. Detta kan användas till cellseparation [2] eller till att fånga partiklar [3]. Målet i detta projekt var att skapa material som skulle bli billigare och möjliggöra enklare fabricering av kanalerna som används inom akustofores än de material som traditionellt används, med bibehållande av tillräckliga akustiskaegenskaper. Detta genomfördes genom att undersöka om tillsättning av glaspärlor eller glasbubblor kunde förbättra de akustiska egenskaperna av en off-stoichiometry-thiol-enes (OSTE) baserad polymer. Hybridprover gjorda på OSTE-polymeren med olika volymandelar av glaspärloroch glasbubblor tillverkades och kategoriserades med avseende på deras akustiska egenskaper med hjälp av pulseeko buffertstång metoden. De akustiska egenskaperna som uppmättes var densitet, attenuering, akustisk impedans och reflektions koefficienten mellan vatten och materialet. Resultatet av projektet visade att tillsättning av glaspärlor ökade den akustiska impedansen i motsatts till glasbubblorna som visade sig minska den. Vidare visade det sig att både tillsättningen av glaspärlor och glasbubblor ökade attenueringen. Det hybridmaterial som visade sig ha de mest lämpliga akustiska egenskaperna var OSTE/glaspärlor med en 40% volymandel av glaspärlor. Den akustiska impedansen hade förhöjts med cirka 60% jämfört med vanlig OSTE. Därför valdes det hybrid-materialet till att tillverka en mikrofluidikkanal. Därefter genomfördes ett partikelfångstexperiment som visade att, OSTE/glaspärlor med en 40% volymandel av glaspärlor, kunde erhålla partikelfångst i kanalen. Detta innebär att en stående våg kunde genereras i kanalen och att den var tillräckligt stark för att kunna fånga partiklarna i mitten av kanalen. Däremot visade utvärdering av kanalens partikelfångsteffektivitet att den inte var lika effektiv som kanaler gjorda av traditionellt använda material. Därför rekommenderas framtida arbete till att designa en optimerad kanaldesign med OSTE/Glas-pärlor 40% materialets egenskaper i åtanke för att förhoppningsvis kunna öka partikelfångst effektivitet.
Babaoglu, De Bruyne Basak [Verfasser]. "The Assessment of Gene Patents Granted in Medical Biotechnology Area in the EU and the US: A Law and Economics Approach / Basak Babaoglu De Bruyne". Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2021. http://d-nb.info/1231436093/34.
Pełny tekst źródłaAlterman, Julia F. "A CNS-Active siRNA Chemical Scaffold for the Treatment of Neurodegenerative Diseases". eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1027.
Pełny tekst źródłaPetersson, Nina. "Optimisation of capillary gel electrophoresis method for enhanced separation of mRNA shortmers". Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351119.
Pełny tekst źródłaMarinho, Flávio Ferreira. "Tabernaemontana catharinensis : caracterização de metabólitos secundários e atividade citotóxica". reponame:Repositório Institucional da UCS, 2014. https://repositorio.ucs.br/handle/11338/984.
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Avik, Joonas. "Deciphering mechanisms underlying tumor heterogeneity using Multi-Omics approaches". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278700.
Pełny tekst źródłaCancer är en komplex sjukdom och en av de största utmaningarna i dagens medicin. Trots stora framsteg i behandlingen av flera cancerformer är återfall och terapiresistens återkommande problem vilket talar starkt för behov av individualiserad behandling. Dessa komplikationer har relaterats till den höga genetiska variabiliteten som observeras inom tumörer, även kallad intratumoral heterogenitet (ITH). Undersökning av relationen mellan ITH och fenotypisk data kan ta fram markörer som är involverade i cancerutvecklingen som bidragare till heterogenitet. Genom att modellera associationen mellan transcriptomen och ITH kan man även hitta kliniskt relevanta biomarkörer. I detta projekt undersöks relationen mellan genutryck och ITH genom att applicera linjär regression. Genom att först reducera antalet variabler i transkriptomen till de diferentiellt utryckta gener, används linjära modellen för att ta fram specifika gener vars utryck kan relateras till ändringar i ITH uppskattad för The Cancer Genome Atlas prover. ITH uppskattas med två algoritmiska metoder, kallade Expands och PhyloWGS. Resultaten visade att förhöjd uttryck an genen DNAJC18 är associerad med lägre ITH uppskattad med Expands bland fyra cancer typer. Trots detta visade inte genutryck och ITH uppskattat med PhyloWGS lika starkt linjärt samband.
Zandian, Arash. "Array-based Autoantibody Profiling and Epitope Mapping". Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-213689.
Pełny tekst źródłaQC 20170905
Wallbing, Linus. "Characterization of heterogeneity of biomolecular interactions using 3rd generation biosensor". Thesis, KTH, Skolan för kemivetenskap (CHE), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215130.
Pełny tekst źródłaStåhl, Olivia. "Heterologous expression and purification of Nicotiana benthamiana Cellulose synthase-like B (NbCslB)". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278581.
Pełny tekst źródłaHemicellulosa syntetiseras av proteiner vars gener återfinns i genfamiljen cellulosasyntas. Enundergrupp till denna genfamilj är cellulosasyntasliknande B, en grupp som till stor del ärokarakteriserad och outforskad. Den vanliga modellorganismen Nicotiana benthamiana haren sådan gen i sitt genom, NbCslB, som kodar för ett membranprotein. Hur denna genuttrycks har tidigare studerats in vivo, men for att kunna studera proteinet in vitro krävs etthållbart protokoll för solubilisering och rening. Denna studie utvärderade användningen avlösningsmedlet n-Dodecyl β-D-maltoside (DDM) för solubilisering, följt av rening medimmobiliserad metalljon-affinitetskromatografi (IMAC), och efter det rekonstitution avproteinet till proteoliposomer. SDS-PAGE och Western blot analyser visade att reningen varlyckad, och att ett rent proteinprov erhållits. När analyserna genomfördes upptäcktes att enanti-FLAG antikropp band särskilt väl till proteinet, och därmed var mycket användbar vidanalys. En aktivitetsanalys genomfördes med det renade proteinet för att karakterisera dessfunktion och utvärdera huruvida proteinet hade bevarat sin aktivitet och konformation efterrening och rekonstitution. Ingen aktivitet kunde detekteras i den enzymatiskaaktivitetsanalysen, vilket indikerade att reningen eventuellt var för hård mot proteinet,alternativt att rekonstitutionen inte var lyckad, eller att förhållandena för analysen inte varoptimala. Dessa resultat kan användas som en bas för framtida forskning om proteinet, därprotokollen för solubilisering, rening och rekonstitution bör vidareutvecklas för att uppnå ettslutresultat där det renade proteinet är aktivt. När ett aktivt och rent proteinprov uppnåtts ärdet möjligt att genomföra ytterligare försök att karakterisera proteinets funktion medenzymatiska aktivitetsanalyser. Resultaten visade också att valet av antikropp kan varaavgörande för att ordentligt kunna analysera detta protein.
Mazzaferro, Eugenia. "Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis". Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14650.
Pełny tekst źródłaYing-Chia, Huang, i 黃英家. "Medical Biotechnology Industry and National Innovation System". Thesis, 1998. http://ndltd.ncl.edu.tw/handle/65709165110527760984.
Pełny tekst źródła國立中山大學
企業管理研究所
86
Comparing with the past cross-section studies exploiting static data, I investigate the development of the medical biotechnology industries (MBTI) of 4 advanced countries (the United States, the United Kingdom, German, Japan) from the holistic and dynamic views, and then try to find the national context that makes the development of MBTI available.By analyzing the secondary data and interviewing experts, I construct a conceptual model of the national innovation system (NIS) for MBTI development, and identify the critical factors of the system. The critical factors of NIS for successful MBTI development reveal as below:1. Copiousness of research fund that depends upon long term GDP growth and large portion of budget allocated to biomedical basic research;2. Plenty of research manpower that depends upon the national educational context and international exchange;3. Abundance of technology sources that depend upon the stock and flow mechanism of knowledge of universities and institutes;4. Generous venture capital that depends upon motivating taxation and supportive financial market;5. Effective new drug governance that depends upon efficient officials with excellent administrative ability;6. High level of technology of related industries that depend upon good medical and pharmaceutical environment;7. Stock of system operation knowledge that depends upon good training system for management teams.By using the NIS model, I then examine Taiwan''s environment and context that cultivate the MBTI, and then raise some stretch and leverage strategies that promote the development of the industry.
Chen, Mei-Ju, i 陳玫汝. "Business Model Analysis of Biotechnology and Medical Companies in Taiwan". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/12662089558365979531.
Pełny tekst źródła國立臺灣大學
國際企業學研究所
92
Under the favorable policy support and a well-established legal environment, the biotechnology and medical industry in developed countries prosper with vigorous market growth and leading technologies. In the past, only few very large pharmaceutical companies were able to finish the whole process of new drug research and development on their own. In contrast, the trend is towards specialization in a particular section of the value chain. The specialization allows small biotech companies to focus on and leverage their core competences through strategic alliances and interdependency. This development provides opportunities for companies in Taiwan with constrained endowments to go across the territory of new drug development. The biotechnology and medical industry in Taiwan faces critical limits in technology and resources. Under such circumstances, how do these biotech and pharmaceutical companies organize their scarce capital assets, construct their business model to strengthen core competences, avoid business risk, cooperate with foreign companies, and eventually enter the new drug development field? We also want to find out which kind of business model is more suitable under Taiwan’s situation (both on a macro and micro level). In order to fully understand the operating models in the stages of growth, we choose Vita, Genovate, Maywufa and TTY as our research targets, and combine with related business model theories to analyze Taiwan’s medical industry and companies’ business models (business scope, profit capture, value proposition, strategy control), cooperative models, and growth paths. The conclusion will set forth the conditions and limits that different models will confront, thus providing a reference for incumbents and new entrants.
ZENG, RONG-SHUN, i 曾頌舜. "Biotechnology research medical industry of the structure, conduct and performance". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/58072473196103307807.
Pełny tekst źródła中華大學
企業管理學系碩士班
103
The life cycle of the species is inseparable from illness and death, how to make human life better quality medical care, survival is more dignified old age each of us must be concerned about the issue. Quality of life and survival of the biotech industry and human health has importance inextricably linked, since the extension of human life, consumption levels increase, resulting in the elderly population aging and an increased incidence of chronic and predictable global biotechnology healthcare industry will continue to expand. According to the medical industry Corp. National Biotechnology Policy Council of 2014.12.02 released data show: in 2013 the company Business Monitor International (BMI) report, the global medical equipment market size of 3,046 billion US dollars, is expected to 2017, up to 4,297 one hundred million US dollars , compound growth rate of 2012 and 2017 of up to 7.1%, while in the pharmaceutical market is expected to 2017 global pharmaceutical spending up to $ 1.2 trillion, a 3.6% annual rate of increase growth, pharmaceutical and medical equipment market in terms of size and growth figures We are very alarming. In summary, the main purpose of this study is to discuss the current situation of China's listed for the medical industry of biotechnology and the use of industrial economics Mason-Bain's "structure - conduct - performance" theory, analysis of industry market structure, firm behavior and operational performance. This paper will (1) The maximum concentration ratio of the top five vendors Hayes measure of market concentration, (2) investigate the behavior and business strategy firm. (3) to measure the performance of the industry change from a financial point of view and adopt regression analysis to investigate the medical biotechnology industry per unit of capital revenue and earnings per share relevant. The results found the following, Taiwan biotech medical industry: (1) That the market concentration, this market revenue belongs in low oligopoly markets. (2) From the manufacturer learned behavior, there are obvious differences in behavior between Taiwan listed biotech medical industry manufacturers. (3) The revenue and earnings per share per unit of capital were positively correlated.
WANG, JIAN-REN, i 王建仁. "The Study of Development and Investment for Taiwan Biotechnology and Medical Industry". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/66z28z.
Pełny tekst źródła大葉大學
管理學院碩士在職專班
107
This study concentrates on the comparison of pharmaceutical, medical device, and health care stocks subordinate to the biotechnology sector in terms of return on investment(ROI), return on assets(ROA), research and development(R&D) expenses, earnings per share(EPS), and revenue growth rate. The findings reveal that large-cap companies could produce much higher ROIs. The higher the revenue growth rate is achieved, the higher ROI is yield. Nevertheless, there is no significant difference in the annualized rate of return among pharmaceutical, medical device, and health care stocks. In the aspects of ROA and EPS, pharmaceutical shares are superior to medical device and health care shares, though pharmaceutical firms spend the most on R&D. One biotech company spending more on R&D or suffering declines in market capitalization would incur a significant EPS loss. Health care firms spend the least on R&D and medical device firms spend nearly the same amount as health care firms. Moreover, pharmaceutical companies achieve the highest growth rate in revenue and medical device companies have the lowest revenue growth rate while no significant differences are found among the three groups of biotech stocks.
Chaw, Shu-Miaw, i 趙淑妙. "A Star of Tomorrow? Taiwan Biotechnology and Medical Industry — The Role of Patent". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/jsptdh.
Pełny tekst źródła國立臺灣大學
財務金融組
103
This study investigates the stock performance of 72 firms listed in TSEC biotechnology and medical index (TBMI) during the period from 2007Q3 to 2014Q2. The main objective of the empirical analysis is to investigate whether firms with new patents outperformed those firms without new patents. The impact of new patents on performance is assayed with stock return rate, whether a new patent issued in previous quarter in a firm, the three-factor Fama-French asset pricing model as well as panel-data-regressions. In the regression analysis we also include a dummy variable for arresting the time effect on the fluctuating stock market and a patent variable, new patent number in the present quarter. The empirical evidence suggests that (1) The firm with new patents in previous quarter and the patent number being only one have a positive impact on the stock return (%) of listed firms, (2) but negative impact on the OTC firms; that (3) increase of new patents has no positive impact on the next quarter in both Listed and OTC firms, and (4) that if there is a newly issued patent in this quarter, additional new patent will not affect the stock return of the next quarter.
Chou, Teh-Ying, i 周德盈. "A Study of Industry-Government-Academia Cooperation Model in Biotechnology and Medical Care". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02759770535138491363.
Pełny tekst źródła國立臺灣大學
國際企業管理組
104
Biotechnology is a very important and prospective investment currently and its applications are used in a variety of areas of science such as agriculture and medicine. The universities and research institutions are long taken as the origin of knowledge for industries. Through a well-designed cooperation, that is, industry-government-academia cooperation, those intellectual property rights, patents and technology generated from academic organizations could be applied in the industries to bolster industrial competency and economic growth. Although government in Taiwan has advocated and subsidized the industry-government-academia collaboration for many years, there are still certain regulations needed to be reformed and problems happened during the cooperation have to be contemplated especially in terms of biotechnology and medicine care fields. The thesis reviews the related literatures about the motives and models of industry-government-academia liaison in biotechnological field and describes the background of biotechnology, current development status, and future growth potentials. Also, the article compiles the norms and regulations with respect to intellectual property rights, patents, and technology transfer produced during the collaboration. Additionally, by analyzing case study “National medical center and Private biomedical enterprise Joint Research and Development” to identify the problems and potential obstacles happened in the time period of collaboration. Finally, the end of the thesis points out the difficulties including IP management, patent licensing, conflict of interests, the regulations for faculty promotion, medical dispute and contents of contract and recommends some resolutions for the universities, research institutions and governments accordingly.
Chen, Yi-Siou, i 陳怡秀. "Study on IPO Age and Firm Value for Taiwan Biotechnology and Medical Industry". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/46518959353100387405.
Pełny tekst źródła國立交通大學
管理學院碩士在職專班管理科學組
99
Previous studies have showed that there is a substantial difference in enterprise performance on short-term and long-term after going public and firm value is also affected by industry category. This study discusses the relationship of IPO age and P/B ratio in Taiwan’s biotechnology and medical industry. A total of 29 listed Taiwanese companies, including 15 from pharmaceutical industry and 14 from medical device industry, were selected as the targets for this study. A total of 122 effective samples were generated from 2001 to 2007. The data were analyzed with the method of independent sample t-test and regression analysis. The first step of this study involves categorizing the samples into different groups based upon their industry categories. This study also employs regression analysis to examine the relationship between enterprise value and enterprise scale, Return on Asset (ROA), debt ratio, IPO age, and different biotech industry categories. The results of this study are summarized as the following: (1) In Taiwan’s biotechnology and medical industry, IPO age and industry category may negatively influence P/B ratio. (2) After the company goes public, the short-term performance generates better results than the long-term performance because the information is not transparent enough and the investors’ expectation to company performance usually exceeds company operation. (3) The IPO age may influence investment return and company growth. Specifically, when IPO age is longer, investment return may tend to be lower and the company growth may be reduced. Keywords: Biotechnology and medical industry, P/B ratio, Industry category, IPO Age, Firm Value, Regression Analysis
KUO, KUN-CHANG, i 郭昆昌. "Evaluation on the Business Performance of Biotechnology and Medical Industry by TOPSIS Method". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/fs7pkt.
Pełny tekst źródła萬能科技大學
經營管理研究所在職專班
106
Due to global enter the aging society and emerging countries of business opportunities for the biotechnology medical development, the government has included the biotechnology medical as a key technology industry in 1982, and the scale of this biotechnology and medical industry is also accompanied by the distribution of domestic and foreign markets by related companies continue to grow rapidly year by year. This research data downloads biotechnology medical industry the financial reports from Taiwan Stock Exchange (TWSE) Market Observation Post System (MOPS) study business performance. According to the financial reports of six listed biotechnology medical companies from 2014 to 2016.This study used CRITIC method to calculated the weight objective of evaluation index in the financial reports, and the TOPSIS method is used to the CRITIC/TOPSIS model, calculates and ranks the sample companies rankings of various financial evaluation index and overall business performance, and then learns the good performance of each company in business performance. The result research shows that during each year, each sample company has different performance changes in each item in the annual financial reports. Profitability and overall business performance affect each other more, and it can be understood from this research the value of the company's investment, and can be used as a reference for investors in the formulation strategies.
Li, Jyun-sian, i 李俊憲. "The Operating Performance of Taiwan’s Biotechnology and Medical Industry:An Application of Data Envelopment Analysis". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/7nk6ad.
Pełny tekst źródła國立屏東商業技術學院
國際企業所
102
In recent years, with advances in biotechnology and medical, in order to improve the quality of life and increase life expectancy, demand for the biotechnology and medical industry is also growing. Whether private or official, investment in human capital and the biotechnology and medical industry continues to increase, more and more cases of large-scale investment, biotechnology and medical industry has gradually become an integral part of an important industry. The purpose of this study was to understand what are the main reasons for the competitiveness of biotechnology and medical industry's most influential. This study uses data envelopment analysis, with two inputs (operating costs, operating expenses) and two outputs (operating revenue and operating income), to analyze Taiwan-listed eighteen biotechnology and medical companies operating efficiency during 2010-2012. The results showed, whether overall technical efficiency, scale efficiency, pure technical efficiency, has been declining and regress in biotechnology and medical industry. A segment industries in a situation of diminishing returns to scale, need to expand to the most suitable management scale. In addition, Taiwan's biotechnology and medical industry there have been problems in production efficiency, and deviate from the fixed or long term returns to scale the optimal scale, is the biotechnology and medical industry needs improvement.
LI, Jimmy, i 李明吉. "Performance Evaluation of Biotechnology Medical Device Industry Using Fuzzy Multi-Objective Data Envelopment Analysis". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/62759415199243272645.
Pełny tekst źródła大葉大學
工業工程與科技管理學系
97
In recent years, because of the fast progress of gene decoding , the array picture of the human genome has already been drawn successfully in 2003, under the government's active promotion, encouragement and investment of the hot twine, progressive biotechnologies day by day make the biotechnology industry of Taiwan growing, which already have embryonic form and effect for the first time, but in technology, developed experiences had disparity of a certain degree with the advanced countries of the world. The paper uses the Fuzzy Multi-objects DEA method and the traditional DEA method to analysis of production efficiency of 13 biotechnology medical device manufacturer in Taiwan from 2005 to 2007. Actual example indicates that, the efficiency of (biotechnology) medical device manufacturers in Taiwan has the sign of soaring year by year, among them it is most obvious to improve with ApexBio and Health & Life . The paper uses the Fuzzy Multi-objects DEA method to analyze the production efficiency of 13 (biotechnology) medical device manufacturers in Taiwan, and the paper analyzes by slack analysis, efficiency analysis, striving direction in order to improve the future of (biotechnology) medical device manufacturer in Taiwan efficiency. After the actual example, the Fuzzy Multi-objects DEA method is not only superior to the traditional DEA in calculating but also relatively have discriminability in assessing the result, the paper conclude the fuzzy model has the higher practicability and effectiveness even more than the traditional DEA method .
WU, TSUNG-HSIN, i 吳宗信. "Corporate Governance and Performance in Publicly Listed Biotechnology and Medical Care Companies in Taiwan". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/69e6fr.
Pełny tekst źródła大葉大學
管理學院碩士在職專班
105
This study focuses on the relationship between the corporate governance and business performance in publicly listed biotechnology and medical care companies in Taiwan. Based on the samples of 104 biotechnology and medical care companies listed on the Taiwan Stock Exchange from 2008 to 2016, we use multiple regression analysis to explore the relationship between business performance and the seven corporate governance variables, which are included in the composition of the board and shareholding structure. The results show that the shareholding ratio of directors and supervisors, the shareholding ratio of managers, the proportions of shares owned by institutional investors, the chairman of the board as the general manager are positively correlated with business performance. However, our results indicate that the size of Board, the proportion of independent directors are positively and negatively correlated with business performance. There is no significant correlation between the shareholding ratio of major shareholders and business performance. Company size and debt ratio are positively and negatively correlated with business performance. R & D expenditure ratio and the year of the two variables have no significant influence. We also investigated the differences in companies of various R & D expenditure levels, regarding the influence of corporate governance variables on business performance. We found that in the high R & D expenditure group company, the shareholding ratio of directors and supervisors, the chairman of the board as the general manager have a more positive impact on business performance. The shareholding ratio of major shareholders, the proportion of independent directors have a more negative impact on business performance. The proportions of shares owned by institutional investors, the shareholding ratio of managers have positive and negative impact on business performance.
Cheng, Kai-Hsiang, i 張凱翔. "Research of Loyalty by Skin Care Products of Biotechnology Pluralism in HS Unite Medical Group". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/qv4st9.
Pełny tekst źródła開南大學
商學院碩士在職專班
104
Nowadays, the conscious of fashion dressing and cosmetic appearance has raised, and not only women, but also men have begun to care for their appearance. Cosmetic user's purpose is to make themselves look healthier and younger. In an array of cosmetic commodities, consumers have to choice in many commodities. Therefore, understanding the use loyalty of the consumer can help firm in decision-making of marketing. In our study, conducted through questionnaires in subjects from July 16, 2015 to Oct 15, 2015, 407 questionnaires were collected, 355 valid questionnaires, the effective rate are 87.2%. Our study found that consumer does not influence from its education, age, area of residence or the price of their skin care product and lead consumer to not focus on their user loyalty. The conclusion of our study has proposed two ways to contact with the customer. The first one is to hold some workshop or experience briefings. The second is to engage social network, because consumers will often collect some information from the internet when they are going to buy any kind of products.
Lin, Yin-Chun, i 林吟純. "The Determinants of Patent Diversification:An Empirical Study of U.S. Biotechnology, Pharmaceutical, and Medical Instrument Industry". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/36063505948497780814.
Pełny tekst źródła逢甲大學
企業管理所
98
In the era of knowledge economy, firm can improve overall competitive advantage by R&D and continually innovation. To achieve target of maximal profit and sustainable development, enterprises not only from the patent to understand the current competitive position in the industry, but also implement diversify strategies to maintain the existing business’s growth. The purpose of this study is to analyze and explore the determinants of patent diversification in U.S. Biological, Pharmaceutical, and Medical Instrument Industries. The observation time is from 2003 to 2008 and the data set include 216 Biological observations, 296 Pharmaceutical observations and 182 Medical Instrument observations in the United States Patent and Trademark Office (USPTO) database. We used the multinomial logistic regression to extract the determining factors of patent citations. This study includes 7 factors of affecting patent diversification: R&D intensity, capital expenditures, firm sizes, firm risk, firm age, diversification, and patent positions. We find that firm age and patent positions are significant in the Biological industry. Firm sizes and diversification are significant in the Pharmaceutical industry. Capital expenditures, firm sizes, diversification, and patent positions are significant in the Medical Instrument industry. Firms can use capital expenditures, firm sizes, firm age, diversification and patent positions to improve patent diversification.
Jung-Mao, Lin, i 林榮茂. "Amendment of Medical Devices Regulations and Its Impacts on Stock Prices in Taiwan Biotechnology Industry". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5235vd.
Pełny tekst źródła國立暨南國際大學
管理學院經營管理碩士學位學程碩士在職專班
107
As most of the countries make certain regulations of Biotechnology, the regulation plays an important role in the company’s policy and operation. The companies will need to increase the cost due to the change of the regulations and it also impacts their margin. Those companies that don’t follow the regulations will face criminal punishment and the reputation will decrease as the result in. Furthermore, the stock price will be impacted. Hence, this research explores the influence on stock price in Taiwan Biotechnology industry with the amendment of EU medical device regulation. The results showed the announcement of regulation amendment has negative impact on stock price in Taiwan Biotechnology industry. Furthermore, since turnover of Biotechnology industry comes from exportation, experimental group and control group were surveyed. The results showed us after the announcement of the regulation amendment, the stock price of these two groups all has a negative abnormal return. The study concluded that the amendment of EU medical device regulation influenced not only the stock price of experimental group but also control group.
Grangeia, Ana Isabel Fernandes. "Prevalence of Cystic Fibrosis and spectrum of CFTR gene mutations in a Portuguese population". Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/89277.
Pełny tekst źródłaTavares, Pedro Miguel de Miranda. "Development of a Smart Sensor Node based on BITALINO". Master's thesis, 2016. https://hdl.handle.net/10216/89316.
Pełny tekst źródłaSantos, Ana Isabel Alves de Sá e. Sousa. "Using different data sources for the identification of asthma patients and those at high risk of adverse outcomes". Doctoral thesis, 2019. https://hdl.handle.net/10216/122304.
Pełny tekst źródła