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Artykuły w czasopismach na temat "Medial Entorhinal Cortex (MEC)"
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Naumann, Robert K., Patricia Preston-Ferrer, Michael Brecht i Andrea Burgalossi. "Structural modularity and grid activity in the medial entorhinal cortex". Journal of Neurophysiology 119, nr 6 (1.06.2018): 2129–44. http://dx.doi.org/10.1152/jn.00574.2017.
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Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question. Fundamental similarities in microcircuits, function, and connectivity suggest a homology between rodent MEC and human posteromedial entorhinal cortex. Both are specialized for spatial processing and display similar cellular organization, consisting of layer 2 pyramidal/calbindin cell patches superimposed on scattered stellate neurons. Recent data indicate the existence of a further nonoverlapping modular system (zinc patches) within the superficial MEC layers. Zinc and calbindin patches have been shown to receive largely segregated inputs from the presubiculum and parasubiculum. Grid cells are also clustered in the MEC, and we discuss possible structure-function schemes on how grid activity could map onto cortical patch systems. We hypothesize that in the superficial layers of the MEC, anatomical location can be predictive of function; thus relating functional properties and neuronal morphologies to the cortical modules will be necessary for resolving how grid activity maps onto cortical architecture. Imaging or cell identification approaches in freely moving animals will be required for testing this hypothesis.
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Deshmukh, Sachin S., D. Yoganarasimha, Horatiu Voicu i James J. Knierim. "Theta Modulation in the Medial and the Lateral Entorhinal Cortices". Journal of Neurophysiology 104, nr 2 (sierpień 2010): 994–1006. http://dx.doi.org/10.1152/jn.01141.2009.
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Hippocampal neurons show a strong modulation by theta frequency oscillations. This modulation is thought to be important not only for temporal encoding and decoding of information in the hippocampal system, but also for temporal ordering of neuronal activities on timescales at which physiological mechanisms of synaptic plasticity operate. The medial entorhinal cortex (MEC), one of the two major cortical inputs to the hippocampus, is known to show theta modulation. Here, we show that the local field potentials (LFPs) in the other major cortical input to the hippocampus, the lateral entorhinal cortex (LEC), show weaker theta oscillations than those shown in the MEC. Neurons in LEC also show weaker theta modulation than that of neurons in MEC. These findings suggest that LEC inputs are integrated into hippocampal representations in a qualitatively different manner than the MEC inputs. Furthermore, MEC grid cells increase the scale of their periodic spatial firing patterns along the dorsoventral axis, corresponding to the increasing size of place fields along the septotemporal axis of the hippocampus. We show here a corresponding gradient in the tendency of MEC neural firing to skip alternate theta cycles. We propose a simple model based on interference of delta oscillations with theta oscillations to explain this behavior.
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Wang, Cheng, Xiaojing Chen, Heekyung Lee, Sachin S. Deshmukh, D. Yoganarasimha, Francesco Savelli i James J. Knierim. "Egocentric coding of external items in the lateral entorhinal cortex". Science 362, nr 6417 (22.11.2018): 945–49. http://dx.doi.org/10.1126/science.aau4940.
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Episodic memory, the conscious recollection of past events, is typically experienced from a first-person (egocentric) perspective. The hippocampus plays an essential role in episodic memory and spatial cognition. Although the allocentric nature of hippocampal spatial coding is well understood, little is known about whether the hippocampus receives egocentric information about external items. We recorded in rats the activity of single neurons from the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC), the two major inputs to the hippocampus. Many LEC neurons showed tuning for egocentric bearing of external items, whereas MEC cells tended to represent allocentric bearing. These results demonstrate a fundamental dissociation between the reference frames of LEC and MEC neural representations.
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GUANELLA, ALEXIS, DANIEL KIPER i PAUL VERSCHURE. "A MODEL OF GRID CELLS BASED ON A TWISTED TORUS TOPOLOGY". International Journal of Neural Systems 17, nr 04 (sierpień 2007): 231–40. http://dx.doi.org/10.1142/s0129065707001093.
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The grid cells of the rat medial entorhinal cortex (MEC) show an increased firing frequency when the position of the animal correlates with multiple regions of the environment that are arranged in regular triangular grids. Here, we describe an artificial neural network based on a twisted torus topology, which allows for the generation of regular triangular grids. The association of the activity of pre-defined hippocampal place cells with entorhinal grid cells allows for a highly robust-to-noise calibration mechanism, suggesting a role for the hippocampal back-projections to the entorhinal cortex.
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Knierim, James J., Joshua P. Neunuebel i Sachin S. Deshmukh. "Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local–global reference frames". Philosophical Transactions of the Royal Society B: Biological Sciences 369, nr 1635 (5.02.2014): 20130369. http://dx.doi.org/10.1098/rstb.2013.0369.
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The hippocampus receives its major cortical input from the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC). It is commonly believed that the MEC provides spatial input to the hippocampus, whereas the LEC provides non-spatial input. We review new data which suggest that this simple dichotomy between ‘where’ versus ‘what’ needs revision. We propose a refinement of this model, which is more complex than the simple spatial–non-spatial dichotomy. MEC is proposed to be involved in path integration computations based on a global frame of reference, primarily using internally generated, self-motion cues and external input about environmental boundaries and scenes; it provides the hippocampus with a coordinate system that underlies the spatial context of an experience. LEC is proposed to process information about individual items and locations based on a local frame of reference, primarily using external sensory input; it provides the hippocampus with information about the content of an experience.
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Luna, Victor M., Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary i in. "Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus". Science 364, nr 6440 (9.05.2019): 578–83. http://dx.doi.org/10.1126/science.aat8789.
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Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs throughN-methyl-d-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.
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Gurgenidze, Shalva, Peter Bäuerle, Dietmar Schmitz, Imre Vida, Tengis Gloveli i Tamar Dugladze. "Cell-Type Specific Inhibition Controls the High-Frequency Oscillations in the Medial Entorhinal Cortex". International Journal of Molecular Sciences 23, nr 22 (15.11.2022): 14087. http://dx.doi.org/10.3390/ijms232214087.
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The medial entorhinal cortex (mEC) plays a critical role for spatial navigation and memory. While many studies have investigated the principal neurons within the entorhinal cortex, much less is known about the inhibitory circuitries within this structure. Here, we describe for the first time in the mEC a subset of parvalbumin-positive (PV+) interneurons (INs)—stuttering cells (STUT)—with morphological, intrinsic electrophysiological, and synaptic properties distinct from fast-spiking PV+ INs. In contrast to the fast-spiking PV+ INs, the axon of the STUT INs also terminated in layer 3 and showed subthreshold membrane oscillations at gamma frequencies. Whereas the synaptic output of the STUT INs was only weakly reduced by a μ-opioid agonist, their inhibitory inputs were strongly suppressed. Given these properties, STUT are ideally suited to entrain gamma activity in the pyramidal cell population of the mEC. We propose that activation of the μ-opioid receptors decreases the GABA release from the PV+ INs onto the STUT, resulting in disinhibition of the STUT cell population and the consequent increase in network gamma power. We therefore suggest that the opioid system plays a critical role, mediated by STUT INs, in the neural signaling and oscillatory network activity within the mEC.
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Ye, Jing, Menno P. Witter, May-Britt Moser i Edvard I. Moser. "Entorhinal fast-spiking speed cells project to the hippocampus". Proceedings of the National Academy of Sciences 115, nr 7 (31.01.2018): E1627—E1636. http://dx.doi.org/10.1073/pnas.1720855115.
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The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in a way that reflects ongoing movement in the environment, they must be able to read out the current speed of the animal. Speed is encoded by speed-responsive cells in both MEC and hippocampus, but the relationship between the two populations has not been determined. We show here that many entorhinal speed cells are fast-spiking putative GABAergic neurons. Using retrograde viral labeling from the hippocampus, we find that a subset of these fast-spiking MEC speed cells project directly to hippocampal areas. This projection contains parvalbumin (PV) but not somatostatin (SOM)-immunopositive cells. The data point to PV-expressing GABAergic projection neurons in MEC as a source for widespread speed modulation and temporal synchronization in entorhinal–hippocampal circuits for place representation.
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Zhang, Sheng-Jia, Jing Ye, Jonathan J. Couey, Menno Witter, Edvard I. Moser i May-Britt Moser. "Functional connectivity of the entorhinal–hippocampal space circuit". Philosophical Transactions of the Royal Society B: Biological Sciences 369, nr 1635 (5.02.2014): 20120516. http://dx.doi.org/10.1098/rstb.2012.0516.
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The mammalian space circuit is known to contain several functionally specialized cell types, such as place cells in the hippocampus and grid cells, head-direction cells and border cells in the medial entorhinal cortex (MEC). The interaction between the entorhinal and hippocampal spatial representations is poorly understood, however. We have developed an optogenetic strategy to identify functionally defined cell types in the MEC that project directly to the hippocampus. By expressing channelrhodopsin-2 (ChR2) selectively in the hippocampus-projecting subset of entorhinal projection neurons, we were able to use light-evoked discharge as an instrument to determine whether specific entorhinal cell groups—such as grid cells, border cells and head-direction cells—have direct hippocampal projections. Photoinduced firing was observed at fixed minimal latencies in all functional cell categories, with grid cells as the most abundant hippocampus-projecting spatial cell type. We discuss how photoexcitation experiments can be used to distinguish the subset of hippocampus-projecting entorhinal neurons from neurons that are activated indirectly through the network. The functional breadth of entorhinal input implied by this analysis opens up the potential for rich dynamic interactions between place cells in the hippocampus and different functional cell types in the entorhinal cortex (EC).
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Campbell, Malcolm G., i Lisa M. Giocomo. "Self-motion processing in visual and entorhinal cortices: inputs, integration, and implications for position coding". Journal of Neurophysiology 120, nr 4 (1.10.2018): 2091–106. http://dx.doi.org/10.1152/jn.00686.2017.
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The sensory signals generated by self-motion are complex and multimodal, but the ability to integrate these signals into a unified self-motion percept to guide navigation is essential for animal survival. Here, we summarize classic and recent work on self-motion coding in the visual and entorhinal cortices of the rodent brain. We compare motion processing in rodent and primate visual cortices, highlighting the strengths of classic primate work in establishing causal links between neural activity and perception, and discuss the integration of motor and visual signals in rodent visual cortex. We then turn to the medial entorhinal cortex (MEC), where calculations using self-motion to update position estimates are thought to occur. We focus on several key sources of self-motion information to MEC: the medial septum, which provides locomotor speed information; visual cortex, whose input has been increasingly recognized as essential to both position and speed-tuned MEC cells; and the head direction system, which is a major source of directional information for self-motion estimates. These inputs create a large and diverse group of self-motion codes in MEC, and great interest remains in how these self-motion codes might be integrated by MEC grid cells to estimate position. However, which signals are used in these calculations and the mechanisms by which they are integrated remain controversial. We end by proposing future experiments that could further our understanding of the interactions between MEC cells that code for self-motion and position and clarify the relationship between the activity of these cells and spatial perception.
Rozprawy doktorskie na temat "Medial Entorhinal Cortex (MEC)"
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Killian, Nathaniel J. "Bioelectrical dynamics of the entorhinal cortex". Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52148.
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The entorhinal cortex (EC) in the medial temporal lobe plays a critical role in memory formation and is implicated in several neurological diseases including temporal lobe epilepsy and Alzheimer’s disease. Despite the known importance of this brain region, little is known about the normal bioelectrical activity patterns of the EC in awake, behaving primates. In order to develop effective therapies for diseases affecting the EC, we must first understand its normal properties. To contribute to our understanding of the EC, I monitored the activity of individual neurons and populations of neurons in the EC of rhesus macaque monkeys during free-viewing of photographs using electrophysiological techniques. The results of these experiments help to explain how primates can form memories of, and navigate through, the visual world.
These experiments revealed neurons in the EC that represent visual space with triangular grid receptive fields and other neurons that prefer to fire near image borders. These properties are similar to those previously described in the rodent EC, but here the neuronal responses relate to viewing of remote space as opposed to representing the physical location of the animal. The representation of visual space may be aided by another EC neuron type that was discovered, free-viewing saccade direction cells, neurons that signaled the direction of upcoming saccades. Such a signal could be used by other cells to prepare to fire according to the future gaze location. Many of these spatially-responsive neurons also represented memory for images, suggesting that they may be useful for associating items with their locations.
I also examined the neuronal circuitry of recognition memory for visual stimuli in the EC, and I found that population synchronization within the gamma-band (30-140 Hz) in superficial layers of the EC was modulated by stimulus novelty, while the strength of memory formation modulated gamma-band synchronization in the deep layers and in layer III. Furthermore, the strength of connectivity in the gamma-band between different layers was correlated with the strength of memory formation, with deep to superficial power transfer being correlated with stronger memory formation and superficial to deep transfer correlated with weaker memory formation. These findings support several previous investigations of hippocampal-entorhinal connectivity in the rodent and advance our understanding of the functional circuitry of the medial temporal lobe memory system.
Finally, I explored the design of a device that could be used to investigate properties of brain tissue in vitro, potentially aiding in the development of treatments for disorders of the EC and other brain structures. We designed, fabricated, and validated a novel device for long-term maintenance of thick brain slices and 3-dimensional dissociated cell cultures on a perforated multi-electrode array. To date, most electrical recordings of thick tissue preparations have been performed by manually inserting electrode arrays. This work demonstrates a simple and effective solution to this problem by building a culture perfusion chamber around a planar perforated multi-electrode array. By making use of interstitial perfusion, the device maintained the thickness of tissue constructs and improved cellular survival as demonstrated by increased firing rates of perfused slices and 3-D cultures, compared to unperfused controls. To the best of our knowledge, this is the first thick tissue culture device to combine forced interstitial perfusion for long-term tissue maintenance and an integrated multi-electrode array for electrical recording and stimulation.
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Tennant, Sarah Anne. "Investigation of circuit mechanisms of spatial memory and navigation in virtual reality". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28915.
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Spatial memory and navigation relies on estimation of location. This can be achieved through several strategies, including the use of landmarks and by path integration. The latter involves inferring location from direction and distance moved relative to a known start point. The neural mechanisms of path integration are not well understood and implementation of experiments that dissociate path integration from alternative strategies is challenging. The roles of specific cell types are also unknown. Although grid cells in layer 2 of the medial entorhinal cortex (MEC) are theorised to be involved given their periodic and repeating firing fields that form a grid-like map that tiles the environment. Two excitatory cell populations have been identified in layer 2 of the MEC. Clusters of pyramidal cells that project to the CA1 are surrounded by dentate gyrus (DG) projecting stellate cells. Both populations have been shown to exhibit grid-like activity. The extent to which these cell types contribute to path integration or other strategies for solving spatial tasks is unknown. To investigate these issues, I developed a spatial memory task for mice, which uses virtual reality to generate sensitive measures of an animal’s ability to path integrate. In this task mice are trained to locate a reward zone marked with a visual cue within a virtual linear track. Use of path integration strategies can be tested in trials in which the reward zone is unmarked. In this task mice can locate the reward zone using either a local beaconing cue or path integration strategies. To assess whether self-motion derived motor information or visual feedback is used for path integration, I manipulated the translation between physical and virtual movement, putting optic and motor feedback in conflict. These manipulations suggest that mice use motor information to locate the reward zone on path integration trials. To test roles of stellate cells in the task I injected adeno-associated virus expressing the light chain of tetanus toxin, conditionally on the presence of Cre, into the MEC of mice expressing Cre specifically in stellate cells. This abolishes synaptic output from stellate cells therefore preventing them from influencing downstream neurons. I find mice with dorsal expression of the tetanus toxin virus in layer 2 stellate cells are unable to locate the reward zone using a local beaconing cue or path integration strategies. In contrast, mice with expression of green fluorescent protein (GFP) were able to locate the reward zone using both strategies. Locating the reward zone using path integration strategies first requires animal’s to learn the reward zone location, as denoted in trials with a beacon cue. To distinguish the role of stellate cells in learning versus execution of the tasks, I temporally modified the activity of stellate cells after mice had learnt to locate the reward zone using both strategies. Temporal control was achieved by use of cre-dependent adeno-associated viruses expressing mutant human muscarinic 4 receptor (hM4). When activated by clozapine - N - oxide (CNO), this receptor opens G-protein inwardly rectifying potassium (GIRK) channels and attenuates neuronal firing. Using this method, the activity of stellate cells can be temporally controlled during task execution and potentially distinguish their involvement in learning and execution of spatial memory tasks. No effect on behavioural performance was seen under these conditions. This may indicate stellate cells are required for learning but not execution of spatial memory tasks that require the use of local beaconing cues or path integration.
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Stensola, Tor. "Population codes in medial entorhinal cortex". Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25419.
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Populasjonskoder i mediale entorhinal korteks Hjernebarken utfører kontinuerlig et velde av kompliserte funksjoner, hvis mekanismer vi kan tjene mye på å forstå. Nevrovitenskap er et relativt nytt fag, men med utrolig moment. Mye vites i dag om enkle nevroners egenskaper, men nevral komputering foregår i store trekk i interaksjonene mellom celler. Men på dette planet er det mange hindere som må overkommes; teknologisk nyvinning og konseptuell modning har ført til at nevrovitenskap gjennom de senere år har kunnet tilnærme seg spørsmal som fanger mekanismer på systemnivå. Hippokampus, som inneholder stedsselektive celler, utgjør et eksperimentelt system som tillater spørsmål om visse kjernemekanismer, slik som hukommelsesfunskjon og intern representasjonsdynamikk, uten streng ekpserimentell kontroll på innkommende og utgående signaler slik man baserer seg på i for eksempel sansenevrovitenskap. I hippokampusforskning er dyrets naturlige adferd en enorm ressurs. På grunn av den sterke tilknytningen til rom kan man ved å korrelere nevral aktivitet til dyrets adferd etablere svært robuste forhold mellom nevronenes aktivitet og funksjon på adferdnivå. Dette har ført til at hippokampusforskning har blitt en foregangsfront på innsamling av store datasett i dyr under normal adferd, samt tolkning av denne i adferdskontekst. Et stort skritt mot å forstå hvordan stedsselektiviteten i hippokampus oppstår og brukes kom med funnet av gitterceller, celler som er aktive i et gittermønster som dekker hele miljøet. Vi vet mye om disse cellenes oppførsel på enkeltcellenivå, men på grunn av teknisk krevende innspillingsteknikk har det vært vanskelig å spille inn nok celler til å forstå hvordan disse kombinerer til en populasjonskode for rom. Denne hindringen har vi nå overkommet, og i første arbeid brukte vi nye teknikker for å spille inn store antall gitterceller innen dyr og viser at gittercellekartet er organisert i moduler, hver med sin egen kartgeometri. Vi viser hvordan disse modulene er fordelt i vevet, og utviklet nye analyser for å beskive modulenes egenskaper. Vi viser at gitterkart i forskjellige moduler inad i dyr ikke bare kan innta forskjellig geometriske former, men også utføre separate operasjoner samtidig på samme eksperimentelle manipulering. Dette er første bevis på slik uavhengig funksjon i gitterkartet, og foreslår hvordan stedsceller kan generere høykapasitetslagring av representasjoner for forskjellige miljø. I andre arbeid beskriver vi hvordan en annen funksjonelt definert cellegruppe i entorhinal korteks fungerer på populasjonsnivå, denne gangen for celler som koder retning til dyret i forhold til miljøet. Vi viser at denne populasjonen har en topografisk fordeling langs samme akse i vevet som gitterceller utviser topografi, men at denne er kontinuerlig i motsetning til gitterkartets modulære fordeling. I siste arbeid viser vi at miljøets geometri bestemmer hvordan gitterkartet ankres til det eksterne rom. Vi beskriver en universal ankringsstrategi som er optimal for å skape størst mulig forskjell mellom populasjonskoder for områder langs rommets grenser. Dette brukes kanskje til å forhindre sanseforvirring av gitterkartet i miljø med geometrisk ambiguøse segmenter. Avhandlingen legger frem første beskrivelser av nevrale mekanismer på populasjonsnivå i entorhinal korteks, og gir flere innsikter i generell organisering av nettverkene som er involvert i stedssans og hukommelseCurrent systems neuroscience has unprecedented momentum, in terms of both technological and conceptual development. It is crucial to study systems mechanisms and their associated functions with behavior in mind. Hippocampal and parahippocampal cortices has proved a highly suitable experimental system because the high level functions that are performed here, including episodic memory formation, are accessible through the clear readout of spatial behavior. Grid cells in medial entorhinal cortex (MEC) have been proposed to account for the spatial selectivity in downstream hippocampal place cells. Until now, however, entorhinal grid cells have only been studied on single cell– or small local ensemble level. The main reason for population studies lagging behind that of hippocampus is the technical difficulties associated with entorhinal implantation and recording. Here we have overcome some of the main technical hurdles, and recorded unprecedented number of cells from distinct functional classes in MEC. We show in Paper 1 that the entorhinal grid map is organized into sub-maps–or modules–that contain grid cells sharing numerous features including spatial pattern scale, orientation, deformation and temporal modulation. We also demonstrate that grid modules in the same system can operate independently on the same input, raising the possibility that hippocampal capacity for encoding distinct spatial representations is enabled by the grid input. We further show in Paper 2 that also head direction cells in entorhinal cortex distribute according to a functional topography along the dorsoventral axis. The head direction system, however, was not modular in contrast to the grid system. Finally, Paper 3 details a common grid anchoring strategy shared across animals and environments. The grid pattern displayed a striking tendency to align to the cardinal axes of the environment, but systematically offset 7.5°. Through simulations, we show that this constitutes an optimal orientation of the grid to maximally decorrelate population encoding of environment border segments, providing a possible link to border-selective cells in the mechanisms that embeds internal representation of space into external frames of reference. These findings have implications for our understanding of entorhinal and hippocampal computations and add several new venues for further investigation.
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Tang, Qiusong. "Structure function relationships in medial entorhinal cortex". Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17163.
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In dieser Arbeit werden Struktur-Funktionsbeziehungen in der medialen entorhinalen Hirnrinde untersucht. Schicht 2 Neurone im medialen entorhinalen Cortex unterteilen sich in calbindin-positive Pyramidenzellen und calbindin-negative Sternzellen. Calbindin-positive Pyramidenzellen bündeln ihre apikalen Dendriten zusammen und formen Zellhaufen, die in einem hexagolen arrangiert sind. Das Gitter von calbindin-positiven Pyramidenzellhaufen ist an Schicht 1 Axonen und dem Parasubiculum ausgerichtet und wird durch cholinerge Eingänge innerviert. Calbindin-positive Pyramidenzellen zeigen stark theta-modulierte Aktivität. Sternzellen sind vertreut in der Schicht 2 angeordnet und zeigen nur schwach theta-modulierte Aktivität, ein Befund, der gegen eine Rolle von zell-intrinsischen Oszillationen in der Entstehung von Theta-Modulation spricht. In der Arbeit wurden Methoden entwickelt, um durch die juxtazelluläre Färbung und Identifikation von Zellen, die räumlichen Feuermuster von Schicht 2 Sternzellen und Pyramidenzellen zu bestimmen. Insbesondere wird gezeigt, dass die zeitlichen Feuermuster von Sternzellen und Pyramidenzellen so unterschiedlich sind, dass auch Daten von nichtidentifizierten extrazellulär abgeleiteten Zellen Sternzellen und Pyramidenzellen zugeordnet werden können. Die Ergebnisse zeigen, dass Gitterzell (engl. grid cell) Feuermuster relativ selten sind und in der Regel in Pyramidenzellen beobachtet werden. Grenzzell (engl. border cell) Feuermuster sind dagegen meistens in Sternzellen zu beobachten. Weiterhin wurde die Anatomie und Physiologie des Parasubiculums untersucht. Die Ergebnisse deuten auf die Existenz eines hexagonalen ‘Gitterzell-gitters’ in der entorhinalen Hirnrinde hin und sprechen für starke Struktur-Funktionsbeziehungen in diesem Teil der Hirnrinde.Little is known about how medial entorhinal cortical microcircuits contribute to spatial navigation. Layer 2 principal neurons of medial entorhinal cortex divide into calbindin-positive pyramidal cells and dentate-gyrus-projecting calbindin-negative stellate cells. Calbindin-positive pyramidal cells bundled dendrites together and formed patches arranged in a hexagonal grid aligned to layer 1 axons, parasubiculum and cholinergic inputs. Calbindin-positive pyramidal cells were strongly theta modulated. Calbindin-negative stellate cells were distributed across layer 2 but avoided centers of calbindin-positive pyramidal patches, and were weakly theta modulated. We developed techniques for anatomical identification of single neurons recorded in trained rats engaged in exploratory behavior. Furthermore, we assigned unidentified juxtacellular and extracellular recordings based on spike phase locking to field potential theta. In layer 2 of medial entorhinal cortex, weakly hexagonal spatial discharges and head direction selectivity were observed in both cell types. Clear grid discharges were predominantly pyramidal cells. Border cells were mainly stellate neurons. Thus, weakly theta locked border responses occurred in stellate cells, whose dendrites sample large input territories, whereas strongly theta-locked grid discharges occurred in pyramidal cells, which sample small input territories in patches organized in a hexagonal ‘grid-cell-grid’. In addition, we investigated anatomical structures and neuronal discharge patterns of the parasubiculum. The parasubiculum is a primary target of medial septal inputs and parasubicular output preferentially targeted patches of calbindin-positive pyramidal cells in layer 2 of medial entorhinal cortex. Parasubicular cells were strongly theta modulated and carried mostly head-direction and border information, and might contribute to shape theta-rhythmicity and the (dorsoventral) integration of information across entorhinal grid scales.
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Ray, Saikat. "Functional architecture of the medial entorhinal cortex". Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17595.
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Schicht 2 des mediale entorhinale Kortex (MEK) beinhaltet die größte Anzahl von Gitterzellen, welche durch ein hexagonales Aktivitätsmuster während räumlicher Exploration gekennzeichnet sind. In dieser Arbeit wurde gezeigt, dass spezielle Pyramidenzellen, die das Protein Calbindin exprimieren, in einem hexagonalen Gitter im Gehirn der Ratte angeordnet sind und cholinerg innerviert werden. Es ist bekannt, dass die cholinerge Innervation wichtig für die Aktivität von Gitterzellen ist. Weiterhin ergaben neuronale Ableitungen und Methoden zur Identifikaktion einzelner Neurone in frei verhaltenden Ratten, dass Calbindin-positive Pyramidenzellen (Calbindin+) eine große Anzahl von Gitterzellen beinhalten. Reelin-positive Sternzellen (Reelin+) im MEK, zeigten keine anatomische Periodizität und ihre Aktivität orientierte sich an den Begrenzungen der Umgebung. Eine weitere Studie untersucht die Architektur des MEK in verschiedenen Säugetieren, die von der Etrusker Spitzmaus, bis hin zum Menschen ~100 Millionen Jahre evolutionäre Vielfalt und ~20,000 fache Variation der Gehirngröße umfassen. Alle Arten zeigten jeweils eine periodische Anhäufung der Calbindin+ Zellen, was deren evolutive Bedeutung unterstreicht. Eine Studie zur Ontogenese der Calbindin Anhäufungen ergab, dass die periodische Struktur der Calbindin+ Zellen, sowie die verstreute Anordnung der Reelin+ Sternzellen schon zum Zeitpunkt der Geburt erkennbar war. Weitere Ergebnisse zeigen, dass Calbindin+ Zellen strukturell später ausreifen als Reelin+ Sternzellen - passend zu der Erkenntnis, dass Gitterzellen funktionell später reifen als Grenzzellen. Eine Untersuchung des Parasubiculums ergab, dass Verbindungen zum MEK präferiert in die Calbindin Anhäufungen in Schicht 2 projizieren. Zusammenfassend beschreibt diese Doktorarbeit eine Dichotomie von Struktur und Funktion in Schicht 2 des MEK, welche fundamental für das Verständnis von Gedächtnisbildung und deren zugrundeliegenden Mikroschaltkreisen ist.The medial entorhinal cortex (MEC) is an important hub in the memory circuit in the brain. This thesis comprises of a group of studies which explores the architecture and microcircuits of the MEC. Layer 2 of MEC is home to grid cells, neurons which exhibit a hexagonal firing pattern during exploration of an open environment. The first study found that a group of pyramidal cells in layer 2 of the MEC, expressing the protein calbindin, were clustered in the rat brain. These patches were physically arranged in a hexagonal grid in the MEC and received preferential cholinergic-inputs which are known to be important for grid-cell activity. A combination of identified single-cell and extracellular recordings in freely behaving rats revealed that grid cells were mostly calbindin-positive pyramidal cells. Reelin-positive stellate cells in MEC were scattered throughout layer 2 and contributed mainly to the border cell population– neurons which fire at the borders of an environment. The next study explored the architecture of the MEC across evolution. Five mammalian species, spanning ~100 million years of evolutionary diversity and ~20,000 fold variation in brain size exhibited a conserved periodic layout of calbindin-patches in the MEC, underscoring their importance. An investigation of the ontogeny of the MEC in rats revealed that the periodic structure of the calbindin-patches and scattered layout of reelin-positive stellate cells was present around birth. Further, calbindin-positive pyramidal cells matured later in comparison to reelin-positive stellate cells mirroring the difference in functional maturation profiles of grid and border cells respectively. Inputs from the parasubiculum, selectively targeted calbindin-patches in the MEC indicating its role in shaping grid-cell function. In summary, the thesis uncovered a structure-function dichotomy of neurons in layer 2 of the MEC which is a fundamental aspect of understanding the microcircuits involved in memory formation.
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Wågen, Rine Sørlie. "Functional Dissection of Local Medial Entorhinal Cortex Subcircuit". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25537.
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The superficial layers of the medial entorhinal cortex(MEC) contain serval functionally specialized spatial cell types. suck a grid cells, head direction cells, border cells and cells with conjunctive properties. It is currently not know how the firing patterns of these vell populations map onto the architecture og the MEC circuit. Results from recent work suggest that there are two largely non-overlapping neuronal populations within superficial layers of MEC with different prosjecting targets. One of them target the hippocampus while the other prosjects extrahippocampally. It has been shown that all funtional MEC cell types prosject to the hippocampus, and a large part of these cells were grid cells. Based on these observations we wanted to investigate if there is a firrerence in fruntional cell distribution of MEC cells projecting to the contralateral MEC and cells prosjecting to hippocampus. Retrogradely transportable recombinant adeno-associated virus expressing Flag-tagged channelrhodopsin-2(ChR2), was injected in left MEC of 6 rats. This introduced optogenetic control over MEC neurons with direct årosjection to the contralateral MEC. Combining optogenetic and electrophysiological in vivo recordings, allowed identification of functional cell types with direct prosjection to the contralateral MEC, as these cells showed minimal response latencies to laser stimulations in the medial entorhinal cortex. We found border cells, head direction cells, non-spatial cells and interneurons with direct projection to the MEC, but no grid cells. This distrubution is in contrasts with the one found to project to the hippocampus, where grid cells are the predominant spatial cell type. More data are requred to determine if the sparsity of respnsive grid cells reflects limited sampling, or if the contralaterally--projecting cell population has distinct functional properties.
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Berndtsson, Christin H. "The Specificity of Output from Medial Entorhinal Cortex". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25538.
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The hippocampal formation(HF) and the parahippocampal region (PHR) have been implicated in learning and memory functions. These regions and their subregions form a highly interconnected and complex microcircuitry, where the entorhinal cortex consitutes the nodal point between the hippocampal formation and the cortex. The entorhinal cortex conssists of ywo functionally distinct subregions. It had been suggested that this diffrence in functional output results from differences in microcircuitry, and input and output characteristics whithin the regions. Therefore, in order to understand the function of the entorhinal cortex and how it contributes to the rest of the HF-PHR network, it is necessary to understand the microcircuity whitin the region. This study investigates the specificity of output from cell populations located in superficial layers of the medial entorhinal cortex. Fluorescent retrograde traces were injected into dorsal dentate gyrus(DG)and the dorsal medial enthorhinal cortex(MEC). Additional immunohistochemistry was performed in order to investigate the chemical markers for the retrogradely labelled cell populations. Labelled cells and possible colocalization of markers were analysedwith fluorescent microscopy. The results indicate the presence of a least three separate cell populations in superficial layers of MEC with different projection patterns and chemical markers. It remains to be seen how the cell populations described here relate to the functionally defined cell populations found in MEC.
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Schmidt-Helmstaedter, Helene. "Large-scale circuit reconstruction in medial entorhinal cortex". Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19197.
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Es ist noch weitgehend ungeklärt, mittels welcher Mechanismen die elektrische Aktivität von Nervenzellpopulationen des Gehirns Verhalten ermöglicht. Die Orientierung im Raum ist eine Fähigkeit des Gehirns, für die im Säugetier der mediale entorhinale Teil der Großhirnrinde als entscheidende Struktur identifiziert wurde. Hier wurden Nervenzellen gefunden, die die Umgebung des Individuums in einer gitterartigen Anordnung repräsentieren. Die neuronalen Schaltkreise, welche diese geordnete Nervenzellaktivität im medialen entorhinalen Kortex (MEK) ermöglichen, sind noch wenig verstanden.
Die vorliegende Dissertation hat eine Klärung der zellulären Architektur und der neuronalen Schaltkreise in der zweiten Schicht des MEK der Ratte zum Ziel. Zunächst werden die Beiträge zur Entdeckung der hexagonal angeordneten zellulären Anhäufungen in Schicht 2 des MEK sowie zur Beschreibung der Dichotomie der Haupt-Nervenzelltypen dargestellt. Im zweiten Teil wird erstmalig eine konnektomische Analyse des MEK beschrieben. Die detaillierte Untersuchung der Architektur einzelner exzitatorischer Axone ergab das überraschende Ergebnis der präzisen Sortierung von Synapsen entlang axonaler Pfade. Die neuronalen Schaltkreise, in denen diese Neurone eingebettet sind, zeigten eine starke zeitliche Bevorzugung der hemmenden Neurone.
Die hier erhobenen Daten tragen zu einem detaillierteren Verständnis der neuronalen Schaltkreise im MEK bei. Sie enthalten die erste Beschreibung überraschend präziser axonaler synaptischer Ordnung im zerebralen Kortex der Säugetiere. Diese Schaltkreisarchitektur lässt einen Effekt auf die Weiterleitung synchroner elektrischer Populationsaktivität im MEK vermuten. In zukünftigen Studien muss insbesondere geklärt werden, ob es sich bei den hier berichteten Ergebnissen um eine Besonderheit des MEK oder ein generelles Verschaltungsprinzip der Hirnrinde des Säugetiers handelt.The mechanisms by which the electrical activity of ensembles of neurons in the brain give rise to an individual’s behavior are still largely unknown. Navigation in space is one important capacity of the brain, for which the medial entorhinal cortex (MEC) is a pivotal structure in mammals. At the cellular level, neurons that represent the surrounding space in a grid-like fashion have been identified in MEC. These so-called grid cells are located predominantly in layer 2 (L2) of MEC. The detailed neuronal circuits underlying this unique activity pattern are still poorly understood. This thesis comprises studies contributing to a mechanistic description of the synaptic architecture in rat MEC L2. First, this thesis describes the discovery of hexagonally arranged cell clusters and anatomical data on the dichotomy of the two principle cell types in L2 of the MEC. Then, the first connectomic study of the MEC is reported. An analysis of the axonal architecture of excitatory neurons revealed synaptic positional sorting along axons, integrated into precise microcircuits. These microcircuits were found to involve interneurons with a surprising degree of axonal specialization for effective and fast inhibition. Together, these results contribute to a detailed understanding of the circuitry in MEC. They provide the first description of highly precise synaptic arrangements along axons in the cerebral cortex of mammals. The functional implications of these anatomical features were explored using numerical simulations, suggesting effects on the propagation of synchronous activity in L2 of the MEC. These findings motivate future investigations to clarify the contribution of precise synaptic architecture to computations underlying spatial navigation. Further studies are required to understand whether the reported synaptic specializations are specific for the MEC or represent a general wiring principle in the mammalian cortex.
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Heys, James Gerard. "Cellular mechanisms underlying spatial processing in medial entorhinal cortex". Thesis, Boston University, 2013. https://hdl.handle.net/2144/12780.
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Thesis (Ph.D.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.Functional brain recordings from several mammalian species including rodents, bats and humans demonstrate that neurons in the medial entorhinal cortex (mEC) represent space in a similar way. Single neurons in mEC, termed 'grid cells' (GCs), fire at regular repeating spatial intervals as the animal moves throughout the environment. In rodents, models GCs have been inspired by research that suggests a relationship between theta rhythmic electrophysiology in mEC and GC firing behavior. The h current time constant and frequency of membrane potential resonance (MPR) changes systematically along the dorsal to ventral axis of mEC, which correlates with systematic gradations in the spacing of the GC firing fields along the same anatomical axis. Despite significant efforts, the mechanism generating this periodic spatial representation remains an open question and the work presented in this thesis is directed towards answering this question One major class of models that have been put forth to explain the grid pattern use interference between oscillations that are frequency modulated as a function of the animal's heading direction and running speed. Parts one and two of this thesis demonstrate how cholinergic modulation of MPR frequency could account for the expansion of grid field spacing that occurs during exploration of a novel environment. The result from these experiments demonstrate that activation of muscarinic acetylcholin receptors produces a decrease in the h current amplitude which causes a decrease in the MPR frequency. Recently unit recordings have shown that GC firing pattern may exist in the mEC of the bat in the absence of these characteristic theta-rhythmic physiological mechanisms. The third section of the thesis details experiments in bat brain slices that were conducted to investigate the cellular physiology of principal neurons in layer II of mEC in the bat and directly test or intrinsic cellular mechanisms that could generate theta in mEC of the bat. Together this work reveals that significant h current is present in rodents and bats. However, the time course of the h current may differ between species such that theta band membrane potential resonance is present in the rodents but is not produced in bat neurons in mEC.
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D'Albis, Tiziano. "Models of spatial representation in the medial entorhinal cortex". Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19306.
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Komplexe kognitive Funktionen wie Gedächtnisbildung, Navigation und Entscheidungsprozesse hängen von der Kommunikation zwischen Hippocampus und Neokortex ab. An der Schnittstelle dieser beiden Gehirnregionen liegt der entorhinale Kortex - ein Areal, das Neurone mit bemerkenswerten räumlichen Repräsentationen enthält: Gitterzellen. Gitterzellen sind Neurone, die abhängig von der Position eines Tieres in seiner Umgebung feuern und deren Feuerfelder ein dreieckiges Muster bilden. Man vermutet, dass Gitterzellen Navigation und räumliches Gedächtnis unterstützen, aber die Mechanismen, die diese Muster erzeugen, sind noch immer unbekannt. In dieser Dissertation untersuche ich mathematische Modelle neuronaler Schaltkreise, um die Entstehung, Weitervererbung und Verstärkung von Gitterzellaktivität zu erklären.
Zuerst konzentriere ich mich auf die Entstehung von Gittermustern. Ich folge der Idee, dass periodische Repräsentationen des Raumes durch Konkurrenz zwischen dauerhaft aktiven, räumlichen Inputs und der Tendenz eines Neurons, durchgängiges Feuern zu vermeiden, entstehen könnten. Aufbauend auf vorangegangenen theoretischen Arbeiten stelle ich ein Einzelzell-Modell vor, das gitterartige Aktivität allein durch räumlich-irreguläre Inputs, Feuerratenadaptation und Hebbsche synaptische Plastizität erzeugt.
Im zweiten Teil der Dissertation untersuche ich den Einfluss von Netzwerkdynamik auf das Gitter-Tuning. Ich zeige, dass Gittermuster zwischen neuronalen Populationen weitervererbt werden können und dass sowohl vorwärts gerichtete als auch rekurrente Verbindungen die Regelmäßigkeit von räumlichen Feuermustern verbessern können. Schließlich zeige ich, dass eine entsprechende Konnektivität, die diese Funktionen unterstützt, auf unüberwachte Weise entstehen könnte.
Insgesamt trägt diese Arbeit zu einem besseren Verständnis der Prinzipien der neuronalen Repräsentation des Raumes im medialen entorhinalen Kortex bei.High-level cognitive abilities such as memory, navigation, and decision making rely on the communication between the hippocampal formation and the neocortex. At the interface between these two brain regions is the entorhinal cortex, a multimodal association area where neurons with remarkable representations of self-location have been discovered: the grid cells. Grid cells are neurons that fire according to the position of an animal in its environment and whose firing fields form a periodic triangular pattern. Grid cells are thought to support animal's navigation and spatial memory, but the cellular mechanisms that generate their tuning are still unknown. In this thesis, I study computational models of neural circuits to explain the emergence, inheritance, and amplification of grid-cell activity. In the first part of the thesis, I focus on the initial formation of grid-cell tuning. I embrace the idea that periodic representations of space could emerge via a competition between persistently-active spatial inputs and the reluctance of a neuron to fire for long stretches of time. Building upon previous theoretical work, I propose a single-cell model that generates grid-like activity solely form spatially-irregular inputs, spike-rate adaptation, and Hebbian synaptic plasticity. In the second part of the thesis, I study the inheritance and amplification of grid-cell activity. Motivated by the architecture of entorhinal microcircuits, I investigate how feed-forward and recurrent connections affect grid-cell tuning. I show that grids can be inherited across neuronal populations, and that both feed-forward and recurrent connections can improve the regularity of spatial firing. Finally, I show that a connectivity supporting these functions could self-organize in an unsupervised manner. Altogether, this thesis contributes to a better understanding of the principles governing the neuronal representation of space in the medial entorhinal cortex.
Książki na temat "Medial Entorhinal Cortex (MEC)"
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Bertram, Edward H. Temporal Lobe Epilepsy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0038.
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Temporal lobe epilepsy, as discussed in this chapter, is a focal epilepsy that involves primarily the limbic structures of the medial temporal lobe (amygdala, hippocampus, and entorhinal cortex). In recent years animal models have been developed that mirror the pathology and pathophysiology of this disease. This chapter reviews the human condition, the structural and physiological changes that support the development of seizures. The neural circuitry of seizure initiation will be reviewed with a goal of creating a framework for developing more effective treatments for this disease.
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Erdem, Uğur Murat, Nicholas Roy, John J. Leonard i Michael E. Hasselmo. Spatial and episodic memory. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199674923.003.0029.
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The neuroscience of spatial memory is one of the most promising areas for developing biomimetic solutions to complex engineering challenges. Grid cells are neurons recorded in the medial entorhinal cortex that fire when rats are in an array of locations in the environment falling on the vertices of tightly packed equilateral triangles. Grid cells suggest an exciting new approach for enhancing robot simultaneous localization and mapping (SLAM) in changing environments and could provide a common map for situational awareness between human and robotic teammates. Current models of grid cells are well suited to robotics, as they utilize input from self-motion and sensory flow similar to inertial sensors and visual odometry in robots. Computational models, supported by in vivo neural activity data, demonstrate how grid cell representations could provide a substrate for goal-directed behavior using hierarchical forward planning that finds novel shortcut trajectories in changing environments.
Części książek na temat "Medial Entorhinal Cortex (MEC)"
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Gauthier, Monique, i Claude Destrade. "Involvement of the Entorhinal Cortex in Memory Processes: Differentiation of Lateral and Medial Parts". W Brain Plasticity, Learning, and Memory, 560. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5003-3_70.
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Nolan, Matt. "A Model for Grid Firing and Theta-Nested Gamma Oscillations in Layer 2 of the Medial Entorhinal Cortex". W Springer Series in Computational Neuroscience, 567–84. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99103-0_15.
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"Medial Entorhinal Cortex (MEC)". W Encyclopedia of Animal Cognition and Behavior, 4153. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-55065-7_301352.
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Moser, Edvard I., Menno P. Witter i May-Britt Moser. "Entorhinal Cortex". W Handbook of Brain Microcircuits, redaktorzy Gordon M. Shepherd i Sten Grillner, 227–44. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190636111.003.0019.
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While decades of study have unraveled some of the basic principles of hippocampal structure and function, the adjacent entorhinal cortex (EC) has remained terra incognita in many respects. Recent studies suggest that the medial part of the entorhinal cortex is part of a two-dimensional metric map of the animal’s changing location in the environment. A key component of this map is the grid cell, which fires selectively at hexagonally spaced positions in the animal’s environment. Grid cells colocalize with other recently discovered medial entorhinal cell types, such as head direction cells, conjunctive grid × head direction cells, border cells, and speed cells. This chapter provides an overview of these functional cell types, their possible relationship to morphological cell types, the intrinsic architecture of the system (including laminar, longitudinal, and modular organization), and the extrinsic connectivity and possible function of both the medial and lateral subdivisions of the entorhinal cortex.
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Austin, James H. "Early Distinctions between Self and Other, Focal and Global, Are Coded in the Medial Temporal Lobe". W Living Zen Remindfully. The MIT Press, 2016. http://dx.doi.org/10.7551/mitpress/9780262035088.003.0006.
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This chapter reviews 2014 Nobel Prize-winning research on the hippocampus and parahippocampus. It considers place cells and grid cells and emphasizes that early primate studies had identified egocentric and allocentric responses in the hippocampus. It also notes that both direction codes and landmark location codes are represented in the retrosplenial cortex as well as in the entorhinal cortex.
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Grossberg, Stephen. "Learning Maps to Navigate Space". W Conscious Mind, Resonant Brain, 572–617. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190070557.003.0016.
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This chapter explains how humans and other animals learn to learn to navigate in space. Both reaching and route-based navigation use difference vector computations. Route navigation learns a labeled graph of angles and distances moved. Spatial navigation requires neurons to learn navigable spaces that can be many meters in size. This is again accomplished by a spectrum of cells. Such spectral spacing supports learning of medial entorhinal grid cells and hippocampal place cells. The model responds to realistic rat navigational trajectories by learning grid cells with hexagonal grid firing fields of multiple spatial scales, and place cells with one or more firing fields, that match neurophysiological data about their development in juvenile rats. Both grid and place cells develop in a hierarchy of self-organizing maps by detecting, learning and remembering the most frequent and energetic co-occurrences of their inputs. Model parsimonious properties include: similar ring attractor mechanisms process linear and angular path integration inputs that drive map learning; the same self-organizing map mechanisms can learn both grid cell and place cell receptive fields; and the learning of the dorsoventral organization of multiple grid cell modules through medial entorhinal cortex to hippocampus uses a gradient of rates that is homologous to a rate gradient that drives adaptively timed learning at multiple rates through lateral entorhinal cortex to hippocampus (‘neural relativity’). The model clarifies how top-down hippocampal-to-entorhinal ART attentional mechanisms stabilize map learning, simulates how hippocampal, septal, or acetylcholine inactivation disrupts grid cells, and explains data about theta, beta and gamma oscillations.
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Martínez-François, Juan Ramón, Nika Danial i Gary Yellen. "Metabolic Seizure Resistance via BAD and KATP Channels". W Ketogenic Diet and Metabolic Therapies, redaktorzy Susan A. Masino, Detlev Boison, Dominic P. D’Agostino, Eric H. Kossoff i Jong M. Rho, 321–35. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197501207.003.0027.
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Ketogenic diets are a very effective treatment for epilepsy. On a ketogenic diet, ketone bodies provide an alternative brain fuel, replacing much of the glucose ordinarily used by the brain. This change in fuel utilization may alter neuronal excitability and help produce the anticonvulsant effect of the diet. Brain fuel utilization can also be modified by a nondietary approach: genetic alteration of the protein BAD, which has known roles in regulating both apoptosis and glucose metabolism. When the metabolic function of BAD is genetically altered in mice, it produces reduced glucose metabolism and increased ketone body metabolism in neurons and astrocytes. This effect is related to regulation of BAD by phosphorylation and is independent of its apoptotic function. Mice with BAD modifications that produce a decrease in glucose metabolism exhibit strong resistance to behavioral and electrographic seizures in vivo. At the cellular level, BAD alteration leads to decreased seizurelike activity in the entorhinal cortex and hippocampus, two brain areas critical for seizure generation and propagation. BAD’s seizure protective effect is lost upon selective deletion of ATP-sensitive potassium (KATP) channels in the dentate gyrus, suggesting that KATP channels in this brain region may mediate BAD’s anticonvulsant effect.
Streszczenia konferencji na temat "Medial Entorhinal Cortex (MEC)"
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Wang, Zongxia, Naigong Yu i Hejie Yu. "Computational Models of Stellate Cells in Layer II of Medial Entorhinal Cortex". W 2021 China Automation Congress (CAC). IEEE, 2021. http://dx.doi.org/10.1109/cac53003.2021.9728543.
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Socher, Karen, Douglas Nunes, Deborah Lopes, Artur Coutinho, Daniele Faria, Paula Squarzoni, Geraldo Busatto Filho, Carlos Buchpighel, Ricardo Nitrini, i Sonia Brucki. "VISUAL MEDIAL TEMPORAL ATROPHY SCALES IN CLINICIAN PRACTICE". W XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda102.
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Background: Visual atrophy scales from the medial temporal region are auxiliary biomarker methods in Alzheimer’s Disease(AD).They may correlated with progression from preclinical to clinical AD. Objective: We aimed to compare medial temporal lobe atrophy (MTA) and entorhinal cortex atrophy (ERICA) scales for magnetic resonance image as a useful tool for probable AD diagnosis and evaluate their accuracy, sensitivity and specificity, regarding clinical diagnosis and 11C-PIB-PET. Methods: 2 neurologists blinded to diagnosis classified 113 adults (over 65y) through MTA and ERICA scales and correlated with sociodemographic data, amyloid brain cortical burden through the 11C-PIB-PET and clinical cognitive status, divided into 30 cognitive unimpaired (CU) individuals, 52 MCI and 31 dementia compatible with AD (DCAD). Results: Inter-rater reliability of these atrophy scales was excellent (0.8- 1) by Cohen analysis. CU group had significantly lower MTA scores (median value 0) than ERICA (median value 1)for both hemispheres. 11C-PIB-PET was positive in 45% of the whole sample. In MCI and DCAD groups, ERICA depicted greater sensitivity and MTA greater specificity. Accuracy was under 70% for both scores in all clinical groups. Conclusion: Our study achieved a moderate sensitivity for ERICA score and could be a better screening tool for DCAD or MCI than MTA score. But, none of them could be considered a useful biomarker in preclinical AD.
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Macedo, Arthur Cassa, Luciano Inácio, Mariano Elisa De Paula França Resende, Antônio Lúcio Teixeira Júnior, Sarah Teixeira Camargos, Francisco Eduardo Costa Cardoso, Paulo Caramelli i Leonardo Cruz De Souza. "EPISODIC MEMORY IMPAIRMENT IN PROGRESSIVE SUPRANUCLEAR PALSY (PSP): A NEUROIMAGING INVESTIGATION". W XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda016.
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Background: Progressive supranuclear palsy (PSP) has been classically considered a “subcortical dementia” with a frontal pattern of cognitive decline, but episodic memory dysfunction also occurs in most patients. However, it remains uncertain whether this is due to executive dysfunction or to the involvement of key brain areas responsible for memory processes. Objective: We aim to identify the specific brain regions underlying episodic memory impairment in PSP. Methods: In this cross-sectional study, we included 21 patients with PSP and 20 healthy controls matched for age, sex, and schooling. Participants underwent the Brief Cognitive Battery (BCB, including the Figures Test for episodic memory) and had brain MRI. Both standard exploratory voxel‐based morphometry and region of interest analyses were performed with FSL software. Results: Compared to controls, PSP patients performed worse (p < 0.001) on the BCB (delayed recall). Adjusting for both age and Frontal Assessment Battery scores, neuroimaging analyses of the correlation between delayed recall (5 minutes) and grey matter volumes yielded significant clusters on medial temporal structures, including the hippocampus, entorhinal cortex, and parahippocampal gyrus (FWE, p < 0.05). Conclusion: Our results suggest that atrophy of medial temporal structures may play a role in episodic memory impairment in PSP, indicating that amnesia in PSP is not due to executive dysfunction.
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Mariano, Lunizia Mattos, Guilherme dos Santos Sousa, Lucas Barbosa Napolitano de Moraes, Yasmim Nadime José Frigo, Ana Flavia Andrade Lemos, Arthur Oscar Schelp i Luiz Eduardo Betting. "Use of lamotrigine in impulse control and social cognition in patients with temporal lobe epilepsy". W XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.654.
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Temporal lobe epilepsy (TLE) is a type of focal epilepsy that can begin in one or more regions of the temporal lobe and spread to adjacent brain tissue via neural connections and can be divided into two types according to the Classification of Epileptic Syndromes (ILAE 2017). The most common is mesial temporal lobe epilepsy, which affects temporal regions such as the hippocampus, entorhinal cortex, amygdala, and parahippocampal gyrus. The second type is lateral or neocortical, where seizures occur in the temporal neocortex (superior, medial and inferior temporal, temporooccipital and temporoparietal gyri and associative senses for auditory, visual and verbal functions). Approximately 60% of patients with mesial TLE associated with hippocampal atrophy are unable to control their seizures even after optimal treatment with various antiepileptic drugs. For these patients, epilepsy surgery can be an effective alternative treatment. After a series of preoperative studies, including medical history and careful neurological examination, complex neurophysiological studies (surface, surface and invasive electroencephalographic video electroencephalogram), neuroimaging studies and neuropsychological evaluations for selected cases. Notably, according to Wiebe and Engel, 2012, surgical treatment of TLE is superior to long-term medical therapy in these selected cases. Because the pathophysiological course of mesial TLE may favor preservation of epileptogenesis even after removal of the primary regions, effective cure in these patients is not always guaranteed. Furthermore, due to the location of mesiotemporal lesions, patients with TLE suffer from stigma, associated with seizure and psychiatric disorders, which affects the quality of life and functioning of these patients. Therefore, this study aims to investigate the efficacy of using antiseizure medications, especially lamotrigine on impulse control, which is also impaired in some mood disorders. Bear Fedio Inventory (BFI) was used to study the effect of lamotrigine and other antizeiures medications on impulse control in patients with TLE. Patients with TLE confirmed by clinical semiology and magnetic resonance imaging findings treated with lamotrigine or other antiseizure medications were included. Only patients older than 18 years and younger than 60 years were investigated. Patients with psychotic symptoms were excluded from this analysis. The BFI was used and applied together with the International Personality Disorder Examination (IPDE). All participants received the questionnaires and were allowed to omit any demographic data that they felt might lead to disclosure of their identity. Ethical approval was obtained from the Ethics Committee of the Botucatu Medical School. The inventory consists of 100 items that must be marked as true or false. Each group of five statements examines one of the following areas: writing tendencies, hypermorality, religious beliefs, anger and impatience, tendency to organize or order, decreased libido, fear and anxiety, guilt, seriousness, sadness, emotion, suspicious and detail-oriented, cosmic interest, belief in personal predestination, persistence and reproducibility, hatred and revenge, addiction, euphoria, and somatization. A high score is 2 or more true items in each domain, or 20 or more items marked true in total. The IPDE, on the other hand, describes personality traits according to ICD-10 and identifies them based on a set of 5 responses with at least two being true to assume that the respondent has that trait, such as impulsivity or borderline. 36 respondents answered the questionnaires and the responses were stored and categorized into two groups, those who take lamotrigine medication and those who do not. With this separation in mind, the answers that defined the personality trait according to the inventories were selected and grouped, the answers were yes or no, and the accumulation of the answers and the score of the accumulation were applied, and the positive and negative cases for the trait were grouped so that the chi-square test could be applied. Nine of the 36 respondents were taking lamotrigine and 27 were taking other medications. For the IPED with the score of impulsivity, there were 7 positives and 2 negatives, the 27 who did not use lamotrigine, 21 with a positive score and 6 negatives. For the BFI, the Hate and Vengeance and Euphoria traits were selected for comparison and to test the hypothesis of decreased impulsivity traits. There was no change in the respondents who use lamotrigine, of the 9, only 2 had a positive score and 7 a negative score, for the non-users tested in this criterion 16 positive and 11 negative. There was not difference for hatred and revenge trail between the groups (P = 0.0543). For the euphoria trait, the values for lamotrigine users were 8 positive and 1 negative, and for non-users were 21 positive and 6 negative (P = 0.466). This preliminary investigation did not show difference for impulse control between patients taking lamotrigine or not. A larger sample size is currently underway to support this observation.