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Tatarski, Miloš. "Molecular mechanism of dBigH1 action". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663021.
Pełny tekst źródłaAttarzadeh, Yazdi Ghassem. "Molecular mechanism of glucocorticoid action". Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/26161.
Pełny tekst źródłaConti, Lucio. "The molecular mechanism of TFL1 action". Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423575.
Pełny tekst źródłaBeastall, J. C. "The mechanism of action of azone". Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380112.
Pełny tekst źródłaWilliams, Daffydd Griffin. "Mechanism of action of penetration enhancers". Thesis, Cardiff University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320625.
Pełny tekst źródłaTaylor, Catherine. "A mechanism of action of strigolactone". Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709140.
Pełny tekst źródłaTaylor, M. R. G. "Mechanism of action of Rad51 paralogs". Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1458671/.
Pełny tekst źródłaPhisit, Prapunwattana Yongyuth Yuthavong. "Mechanism of antimalarial action of tetracycline /". abstract, 1986. http://mulinet3.li.mahidol.ac.th/thesis/2529/29E-Phisit-P.pdf.
Pełny tekst źródłaDíaz, i. Cirac Anna. "Mechanism of action of cyclic antimicrobial peptides". Doctoral thesis, Universitat de Girona, 2011. http://hdl.handle.net/10803/38252.
Pełny tekst źródłaAquesta tesi doctoral resulta de la combinació d’estudis mitjançant tècniques experimentals i computacionals amb l’objectiu d’entendre el mecanisme d’acció de "de novo" decapèptids cíclics amb elevada activitat antimicrobiana. Experimentalment, es va avaluar la influència de la substitució dels residus de fenilalanina per triptòfan en la seva activitat antimicrobiana i també la seva estabilitat sèrum humà, per tal de valorar la seva possible aplicació terapèutica envers el càncer. Per altra banda, es va simular la interacció del pèptid BPC194 c(KKLKKFKKLQ), millor candidat de la biblioteca de pèptids cíclics, amb models aniònics de bicapa lipídica. Els resultats van posar en manifest una relació estructura-funció derivada de la conformació estable dels pèptids que participen directament en la permeabilització de la membrana. Es va procedir doncs al disseny racional de nous pèptids cíclics sent el pèptid BPC490 el que va presentar una millor activitat bacteriana en comparació amb el pèptid més actiu de la llibreria original.
Reißmann, Stefanie. "Mechanism of Action of Group II Chaperonins:". Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-73195.
Pełny tekst źródłaHirschkorn, Martin C. "Dynamic Model of a Piano Action Mechanism". Thesis, University of Waterloo, 2004. http://hdl.handle.net/10012/877.
Pełny tekst źródłaPlested, Charles Paul. "Mechanism of action of seronegative myasthenia gravis". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301392.
Pełny tekst źródłaKeane, Richard. "HPMA copolymer-aminoellipticine conjugates : mechanism of action". Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269617.
Pełny tekst źródłaBeecroft, Marikka Shannon. "Antimicrobial chelators and their mechanism of action". Thesis, Durham University, 2019. http://etheses.dur.ac.uk/12933/.
Pełny tekst źródłaMatkar, Smita S. "Mechanism of action of potential anticancer drugs". Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2368.
Pełny tekst źródłaChant, Eleanor Laura. "The mechanism of action of ColE1 Rcd". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613713.
Pełny tekst źródłaJackson, Natalie Diane. "The mechanism of action of peroxygen biocides". Thesis, University of York, 1999. http://etheses.whiterose.ac.uk/9825/.
Pełny tekst źródłaBagnobianchi, A. "The molecular mechanism of action of Bendamustine". Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1461456/.
Pełny tekst źródłaNovikova, Natalia. "Mechanism of action of emergency contraceptive pill". Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2151.
Pełny tekst źródłaNovikova, Natalia. "Mechanism of action of emergency contraceptive pill". University of Sydney, 2007. http://hdl.handle.net/2123/2151.
Pełny tekst źródłaThe number of unwanted pregnancies has not decreased in recent years and this should be addressed. Emergency contraception may be effective when used correctly having the advantage that it can be used after an episode of unprotected sexual intercourse (when regular contraception has failed or was not used). In this research project I set out to explore some of the major reasons why there are still many unwanted pregnancies in Australia. I decided to focus on the use and non-use of emergency contraception, e.g. emergency contraception pill (ECP) “method failures” are not well understood because the actual mechanisms of action are still unclear. There is evidence ECP can effectively interfere with follicle growth and ovulation. It is much less clear is whether ECP is able to interfere with fertilization and implantation, in a way, which may make it acceptable to those who have strong religious beliefs in fertilization being the start of new life. Emergency contraception has the potential to prevent many unwanted pregnancies when unprotected intercourse has occurred. It has relatively high efficacy in many studies, but true method failures are not well understood. By contrast, many unwanted pregnancies occur for “social reasons” where emergency contraception has not been used. I set out to study changes in knowledge and usage of emergency contraception in these groups of Australian women seeking termination of pregnancy: 1. Before a dedicated emergency contraception pill (ECP) pack (Postinor) became available in Australia 2. One year after dedicated ECP became available on prescription 3. One year after the ECP pack became available “over the counter” without prescription. Ninety-nine women were recruited during their presentation with a request for ECP at the six Family Planning Clinics in Australia. All women took LNG 1.5mg in a single dose during the clinic consultation. A blood sample was taken immediately prior to ingestion of the ECP for estimation of serum LH, oestradiol and progesterone levels to calculate the day of the menstrual cycle. Based on these endocrine data we estimated the timing of ovulation to within a ±24-hour period with an accuracy of around 80%. Women were followed up 4-6 weeks later to ascertain pregnancy status. The effectiveness of ECP when taken before and after ovulation was determined. Three women in this study became pregnant despite taking the ECP (pregnancy rate 3%). All three women who became pregnant had unprotected intercourse between day -1 and 0 and took the ECP on day +2, based on endocrine data. Day zero was taken as ovulation day. Among seventeen women who had intercourse in the fertile period of the cycle and took the ECP after ovulation occurred (on day +1 to +2) we could have expected 3 or 4 pregnancies, based on Wilcox et al data. Three pregnancies were observed. Among 34 women who had intercourse on days –5 to –2 of the fertile period, and took ECP before or around ovulation, four pregnancies could have been expected, but none were observed. The major discrepancies between women’s self-report of stage of the cycle and the dating calculation based on endocrine data were observed in this study. These data are supportive of the concept that the LNG ECP has little or no effect on post-ovulation events, but is highly effective before ovulation. Our interpretation of the data in terms of timing of treatment relative to ovulation may explain why EC with LNG works sometimes and fails at other times. A larger study is needed to prove this hypothesis. To investigate other reasons for such a high rate of unwanted pregnancy, which probably has a larger impact we looked into womens knowledge of and attitude towards ECP. Seven hundred and eighteen women participated in this study by answering a questionnaire consisting of 15 questions on their demographic and reproductive characteristics as well as the knowledge about the ECP, e.g. 208 women were enrolled before the ECP was marketed in Australia in 2001, 308 after it was marketed and 202 after it became available over the counter (Group 1, 2, and 3, respectively). We found that the participants who have heard about ECP were significantly younger (p<0.005). The mean age of women who have never heard about of ECP was 29.8 years compared to 26.3 years in women who have heard about ECP. More women were aware about the ECP after it became available over the counter. Women in group 2 had higher educational level in comparison to women in group 2 and 3 (p<0.005). There was significant trend in increased use of ECP in women of higher educational level (p<0.005). The use of ECP did not increase significantly with improved availability and access to the ECP amongst women presenting for termination of pregnancy. Wider availability of he ECP pack in Australia and an easier access to it has increased women’s awareness about the ECP. However, the use of ECP has not increased. This study provides better understanding of mechanism of action of LNG ECP and an explanation to the method failure. It also reveals poor knowledge about ECP despite its wider availability and accessibility. Improving these is a worldwide challenge for family planners and all health professionals.
Muraro, Lucia. "Studies of Botulinum Neurotoxins Mechanism of Action". Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425607.
Pełny tekst źródłaDavoodi, Jamshid. "Bacillus circulans xylanase: Stability and mechanism of action". Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/10216.
Pełny tekst źródłaSpiro, Simon George. "The mechanism of action of iminosugars as antiretrovirals". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7fc4ae01-bdec-49d0-afec-e0f3e9e8f41d.
Pełny tekst źródłaRotjanapun, Kunjana. "Dietary components and cancer risk : mechanism of action". Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/75144/.
Pełny tekst źródłaFrith, Julie C. "Studies into the mechanism of action of clodronate". Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299577.
Pełny tekst źródłaMartin, Duncan J. "Mechanism of action of the anticonvulsant drug gabapentin". Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395181.
Pełny tekst źródłaChurcher, Mark Jonathan. "Studies on the mechanism of action of Tat". Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359975.
Pełny tekst źródłaHurley, Laurence H. "Biosynthesis and mechanism of action of antitumor antibiotics". Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760690.
Pełny tekst źródłaNawaz, Zafar. "Molecular Mechanism of Action of Steroid Hormone Receptors". Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc798398/.
Pełny tekst źródłaWong, Tin Lok. "Mechanism of action of silicon in cell signalling". Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709339.
Pełny tekst źródłaPua, Khian Hong. "Investigating the Mechanism of Action of Sanglifehrin A". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467488.
Pełny tekst źródłaChemistry and Chemical Biology
Shrestha, Sanjib K. "Novel Aminoglycosides: Bioactive Properties and Mechanism of Action". DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/2073.
Pełny tekst źródłaAshraf, Sadia. "Study of mechanism of action of Scorpion neurotoxins". Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423586.
Pełny tekst źródłaRIASSUNTO Gli Scorpioni sono importanti rappresentanti del phylum Artropodi. Essi si sono ben adattati a condizioni ambientali estreme e giocano un ruolo fondamentale in diversi ecosistemi. Allo stesso tempo gli scorpioni sono responsabili di più di 1.2 milioni di punture per anno con quasi 3000 morti in tutto il mondo. Sono due le famiglie di scorpioni pericolose per l’uomo: Buthida e Hemiscorpiidae. Le punture di scorpione possono causare da effetti lievi come rossore, e dolore a effetti gravi che causano danni a diversi organi ed eventualmente la morte del soggetto colpito. Il veleno di scorpione è costituito da diversi componenti come peptidi a basso peso molecolare, lipidi ed enzimi. Gli effetti patologici della puntura di scorpione sono causati dalla presenza di diverse tossine (neurotossina, cardiotossina, nefrotossina, tossina emolitica) e diversi enzimi (fosfodiesterasi, fosfolipasi, ialuronidasi) nel veleno. Dato che gli scorpioni hanno una lunga storia evolutiva, durante questo lungo periodo hanno sviluppato un serie di peptidi e proteine che possiedono diverse funzioni biologiche. Grazie alla loro abbondanza e quindi alla facilità d’isolamento, i componenti del veleno più studiati sono le tossine che esplicano la loro azione sui canali ionici i quali sono stati molto studiati e descritti in dettaglio in letteratura. Recentemente è stata descritta una nuova classe di metalloproteasi di scorpione capace di proteolizzare le proteine SNARE che è stata denominata Antarease. Fino ad ora le proteine SNARE che hanno un ruolo chiave nel processo di neuroesocitosi, sono state descritte essere il bersaglio molecolare solo di neurotossine batteriche quali le tossine del tetano e del botulismo. Per studiare questa nuova classe di metalloproteasi, abbiamo analizzato l’azione di diversi veleni di scorpioni sia su proteine SNARE ricombinanti sia su modelli di neuroni primari in coltura. Questo studio ha dimostrato la presenza di metalloproteasi simili all’Antarease in specie di scorpioni Buthus eupeus e Orthochirus scrobiculosus e che questi enzimi sono in grado di proteolizzare in maniera specifica le proteine SNARE.
Salazar, Montoya Vivian Angélica. "Exploring the mechanism of action of human antimicrobial ribonucleases". Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/310611.
Pełny tekst źródłaHuman ribonucleases are a heterogeneous group of proteins belonging to the superfamily of RNase A. These proteins are characterized by their ability to hydrolyse ribonucleic acids and the presence of antimicrobial activity against various pathogens including bacteria, fungi, parasites and viruses. The first objective of this doctoral study is focused on the antimicrobial characterization of native Ribonuclease 3 forms purified from eosinophils. Native forms present posttranslational modifications giving different glycosylation grades that modulate their activity during inflammatory processes. This study aims to establish the antimicrobial properties of native forms purified from eosinophils and their activity in a membrane model system. Results indicate that post-translational modifications contribute to the the protein biological activities, suggesting a related physiological role. As a second objective, we evaluated for the first time the antifungal activity of the antimicrobial RNase 3 and RNase 7 against Candida albicans, an eukaryotic pathogen selected as a simple model to test the antimicrobial mechanism of action. Both human ribonucleases displayed a high antifungal activity. Results highlighted a dual mechanism of action, where cell lysis takes place at high protein concentration, while depolarization, cell internalization and cellular RNA degradation is achieved at sublethal doses. Finally, the last objective is focused on the characterization of ribonuclease 8, also called the placental RNase, the most recent human ribonuclease described. RNase 8 has gained and lost one cysteine residue in non-conserved positions in a mechanism called "disulphide shuffling". The protein tendency to aggregate required the design of an alternative purification protocol. We analysed its antimicrobial abilities, suggesting a possible role in innate defence. The results of this study confirmed the high antimicrobial activity of several human ribonucleases from the RNase A superfamily suggesting an ancestral role in the host immune defence response. The study contributed to the understanding of their mechanism of action and set the basis for applied drug design.
Sardari, Lodriche Soroush. "Natural antifungals, screening, isolation, synthesis, and mechanism of action". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0006/NQ29103.pdf.
Pełny tekst źródłaPirola, Byron Antony. "Structure and mechanism of action of 5-aminolevulinate synthase /". Title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09php671.pdf.
Pełny tekst źródłaBarbara, Jeffrey A. J. "The mechanism of action of tumour necrosis factor-[alpha] /". Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phb229.pdf.
Pełny tekst źródłaMassignani, Marzia. "Polymersomes for intracellular delivery : mechanism of action and applications". Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555130.
Pełny tekst źródłaMatthews, Charles S. "Investigations into the mechanism of action of antitumour quinols". Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659198.
Pełny tekst źródłaLewis, John. "Mechanism of action of overbased additives in hydrocarbon media". Thesis, University of East Anglia, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280936.
Pełny tekst źródłaWatson, Jeannette Moira. "5-HT autoreceptors : pharmacological characterisation and mechanism of action". Thesis, University of Hertfordshire, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275119.
Pełny tekst źródłaGudgeon, M. C. "Studies on the mechanism of action of cyclosporin A". Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378279.
Pełny tekst źródłaRomero-Canelón, Isolda. "Design and mechanism of action of organometallic anticancer complexes". Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/55211/.
Pełny tekst źródłaOoi, Nicola Chooi Twan. "Antibacterial activity and mechanism of action of lipophilic antioxidants". Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5905/.
Pełny tekst źródłaArafiles, Jan Vincent Valenzuela. "Macropinocytosis-Inducing Peptides: Identification, Utility, and Mechanism-of-Action". Kyoto University, 2020. http://hdl.handle.net/2433/259021.
Pełny tekst źródłaSlaughter, Alison Paige. "Mechanism of action of allosteric HIV-1 integrase inhibitors". The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428684473.
Pełny tekst źródłaVekariya, Rakesh. "TOWARDS UNDERSTANDING THE MECHANISM OF ACTION OF ABUSED CATHINONES". VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2841.
Pełny tekst źródłaDeans, Bryan. "Studies on the mechanism of action on antitumour imidazotetrazinones". Thesis, Aston University, 1994. http://publications.aston.ac.uk/11048/.
Pełny tekst źródłaKomaragiri, Shravan Kumar. "Mechanism of action of ID4 as a tumor suppressor". DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2016. http://digitalcommons.auctr.edu/dissertations/3335.
Pełny tekst źródłaFan, Kit Man. "Studies on the molecular mechanism of action of artemisinins /". View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202008%20FAN.
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