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Artykuły w czasopismach na temat "Matrices de délivrance de principes actifs"
Blanchemain, Nicolas, Florence Siepmann i Juergen Siepmann. "Implants pour la délivrance de principes actifs". médecine/sciences 33, nr 1 (styczeń 2017): 32–38. http://dx.doi.org/10.1051/medsci/20173301006.
Pełny tekst źródłaNicolas, Julien, i Patrick Couvreur. "Les nanoparticules polymères pour la délivrance de principes actifs anticancéreux". médecine/sciences 33, nr 1 (styczeń 2017): 11–17. http://dx.doi.org/10.1051/medsci/20173301003.
Pełny tekst źródłaBourges, J. L., E. Touchard, L. Kowalczuk, M. Berdugo, A. Thomas-Doyle, A. Bochot, A. Gomez, F. Azan, R. Gurny i F. Behar-Cohen. "Dispositifs de délivrance de principes actifs pour des applications ophtalmologiques". Journal Français d'Ophtalmologie 30, nr 10 (grudzień 2007): 1070–88. http://dx.doi.org/10.1016/s0181-5512(07)79290-2.
Pełny tekst źródłaAndrieux, Karine, i Patrick Couvreur. "Nanoparticules pour la délivrance cérébrale de principes actifs ou d’agents de contraste. Application à la maladie d’Alzheimer". Biologie Aujourd'hui 206, nr 3 (2012): 185–90. http://dx.doi.org/10.1051/jbio/2012019.
Pełny tekst źródłaDieng, Sidy mouhamed, Ahmédou Bamba Koueimel Fall, Papa Mady SY, Alphone Rodrigue Djiboune, Mamadou Niass, Louis Augustin Diagua Diouf, Gora Mbaye, Oumar Thioune i Mounibé Diarra. "Nanogels obtenus par interactions électrostatiques ; Formulation, caractérisations et études de libérations." Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB) 2, nr 1 (8.07.2023): 11–22. http://dx.doi.org/10.57220/jatpb.v2i1.35.
Pełny tekst źródłaRozprawy doktorskie na temat "Matrices de délivrance de principes actifs"
Loth, Capucine. "Exploring hydrogels based on the self-assembly of a Fmoc-based tripeptide : physicochemical characterization and antibacterial properties". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAE002.
Pełny tekst źródłaHydrogels are 3D networks of fibers that retain large amounts of water when swollen. Due to their biocompatibility, they are increasingly used for drug delivery. To develop antibacterial peptide-based hydrogels, this dissertation presents two studies based on the use of a fluorenylmethoxycarbonyl (Fmoc)-protected phosphorylated tripeptide that can self-assemble into a hydrogel. In the first study, different preparation conditions (pH, salt, presence of polysaccharide) were investigated to obtain a self-healing and antibacterial hydrogel capable of releasing an antibiotic, florfenicol. In the second study, a solid-phase peptide and phosphoramidite synthesis strategies were combined to add florfenicol to the Fmoc-protected tyrosine phosphate via a phosphodiester, which can be cleaved by nucleases produced by bacteria. Encouraging results showed the formation of the targeted compound, paving the way for the design of a self-defensive antibacterial peptide
Chabre, Yoann. "Matériaux dendritiques pour la délivrance de principes actifs". Nice, 2006. http://www.theses.fr/2006NICE4070.
Pełny tekst źródłaThis work deals with dendritic prodrugs synthesis and characterization for drug delivery towards biomedical therapeutics and ophthalmologic applications. Dendrimers are well-defined, discrete macromolecules with a high degree of molecular uniformity and monodispersity, which possess cavities and a strictly controlled number of functional groups on their periphery. Those features, combined with polymers advantages, multivalency, adhesive or molecular recognition effects make them attractive for the development of dendritic drug delivery systems. The first part of this work focussed on the selection and the optimization of specific structural elements in order to offer satisfactory compromise between structure-properties relationships (water solubility, biocompatibility and reduced toxicity, enzymatic degradability) and to synthesize new symmetric dendritic architectures bearing drugs in a covalent way for ophthalmology applications. The synthesis of non-symmetric structures was elaborated in a second part. Introduction of additional structural variables contributed to the molecular complexity enhancement in order to modulate in a more efficient way drug delivery processes and to their possible use in polytherapy. Preliminary studies concerning enzymatic degradation of our dendritic prodrugs are described in the last part of this work. In vitro studies highlighted “multiplicity effect” and the influence of several structural parameters modulating drug delivery processes
Ramadan, Alyaa Adel. "Etude de systèmes lipidiques de délivrance de principes actifs". Phd thesis, Université d'Angers, 2010. http://tel.archives-ouvertes.fr/tel-00586347.
Pełny tekst źródłaRamadan, Alyaa. "Etude de systèmes lipidiques de délivrance de principes actifs". Angers, 2010. http://www.theses.fr/2010ANGE0030.
Pełny tekst źródłaThis thesis highlighted the importance of lipid-based carriers and their pharmaceutical implications in the delivery of drugs of different nature for dermal and oral administration. The general introduction provided an overview of the types of lipid-based delivery systems with more emphasis on solid lipid nanoparticles ( SLN ) and lipid nanocapsules ( LNC ). In the first part, Clobetasol propionate ( CP )-loaded SLNs were prepared to improve the performance of long term topical corticosteroid therapy. Skin permeation ex-vivo data indicated that the skin retention of CP increased using the SLN test hydrogel formulation more than that a commercial gel. The second part focused on LNCs. Chapter 1 of this part aimed at encapsulating the hydrophilic macromolecule, fondaparinux ( F ), into LNCs by a novel patented two microemulsion ( ME ) strategy. This is based on the incorporation of a precarrier F-loaded ME into a second ME prepared using the phase inversion temperature plus temperature cycling methodology. LNCs formulated using Imwitor/Span were the best ( 59 nm and 48% incorporation efficiency). Chapter 2 aimed at enhancing the loading of anionic F by using cationic LNCs (~50 nm and 80-100% entrapment efficiency). In vivo study in rats administered F-loaded LNCs orally in comparison with a solution market product demonstrated that caionic LNCs significantly increased F bioavaibility and anti-factor Xa effect in a dose-dependent fashion. Data provided a proof of concept for the potential oral bioavailability of F. This offers great promise for a more convenient chronic anticoagulant therapy replcing the currently used injections
Louttani, Salma. "Boite moléculaire photostimulable pour la délivrance de principes actifs". Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASF088.
Pełny tekst źródłaThe work described in this thesis consists in the study of new vectors for active substances based on cyclodextrin (CD) nanotubes. The first part discussed about the choice of γ-CD as nanotube precursor, thanks to the results obtained by complexation of several active substances. After large scale synthesis of γ-CD nanotubes, the complexation conditions have been optimized and extended to nanotubes with different length and inter-CD bridges. A correlation between structure and the kinetics of active substance release has been carried out and allowed to refine the structure according to the has desired properties. For this purpose, the synthesis of a nanotube bearing photoswitchable extremities based on azobenzene moieties been investigated. After the synthesis optimization of a new heterodifunctional azobenzene derivative, the synthesis of a new polyrotaxane has been optimized to obtain a number of cyclic molecules and azobenzenes compatible with the structure of the desired nanotube. This compound has been successfully isolated and characterized such as new nanotube. A photochemical study evidenced the opening nanotube under UV stimuli, which lead to the use of the nanotube/curcumin complex in biology
Skandarani, Nadia. "Développement de nanocapsules lipidiques pour la délivrance de principes actifs". Thesis, Besançon, 2014. http://www.theses.fr/2014BESA2071/document.
Pełny tekst źródłaThe development of nanotechnology in the medical field has attracted considerable interest in recent years, including the use of nanoparticles for drug delivery. Nanoparticles offer unique opportunities for delivery of active drugs such as genes (gene therapy), anti-cancer (chemotherapy) or photosensitizers (photodynamic therapy, PDT). The major challenge, however, remains the delivery of therapeutic molecules to their site of action while keeping their integrity and their therapeutic effect.The research focus of this thesis is the use of lipid nanocapsules as a multifunctional platform for the delivery of drugs. One goal is the development of stable lipid nanocapsules, functionalized with polyethyleneimine and capable of effectively delivering a plasmid DNA and an anti-cancer (paclitaxel) as part of a combination therapy. The applications of these nanocarriers for transfection and delivery of chemotherapeutic were performed in vitro.Moreover, the ability of lipid nanocapsules to encapsulate photosensitizers for photodynamic therapy has been studied in vitro, and the results showed that the encapsulation of two molecules of PS in the nanocapsules allows a synergy photodynamic effect while protecting the PS from photo degradation.Finally, encapsulating an ion channel TRPM8 agonist (menthol) is the subject of the last chapter. The study by calcium imaging of the release of this lipophilic molecule in vitro confirmed the potential of lipid nanocapsules as nanocarriers of drugs
Castagnos, Pauline. "Vésicules catanioniques : design et mécanismes de délivrance de principes actifs". Toulouse 3, 2011. http://thesesups.ups-tlse.fr/1412/.
Pełny tekst źródłaSugar-derived catanionic surfactants self-assemble spontaneously into vesicles, which can encapsulate either hydrophilic drugs inside their aqueous core or hydrophobic and amphiphilic drugs inside their bilayer. Their biocompatibility, as well as their stability under time and dilution in biological media, allow to consider the use of these organized molecular systems for drug vectorization and delivery. In the present work, a mechanistic study showed these eco-designed and adjustable systems are able to fuse spontaneously with lipid assemblies mimicking cell membranes, provided that these latter present organization defects inside the bilayer. Cellular interaction mechanisms of such supramolecular systems were elucidated on cancer cell lines, by confocal microcopy and flow cytometry techniques. On the one hand, macropinocytosis, clathrin and caveolae pathways were shown to intervene as major active processes of cellular uptake of vesicles. The simultaneous intervention of these three pathways of endocytosis enables a progressive drug release through complementary mechanisms. On the other hand, experimental results verified that catanionic vesicles are capable of fusing with cell membranes. This spontaneous membrane fusion, concomitant with endocytosis, provides to these innovative systems the ability to deliver hydrophilic compounds directly inside cytoplasm. Numerous perspectives of such systems can thus be foreseen. An application towards vectorization of photosensible drugs was initiated in the present work, in order to fight cutaneous cancer through photodynamic therapy. These vectors, charged with hydrophobic active principles, showed enhanced stability and promising in vitro results for treatment of skin melanoma and oral squamous carcinoma
Racine, Lisa. "Elaboration de biomatériaux pour la délivrance contrôlée de principes actifs hydrophobes". Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV061/document.
Pełny tekst źródłaDue to their high biocompatibility, macroscale hydrogels have been studied as promising materials for the design of drug delivery systems (DDS). Such systems devoted to the local administration and prolonged drug release can improve the efficacy of pharmaceutical coumpounds while limiting undesired side-effects. Hydrogels present a high water content and soft consistency with mechanical properties that can match those of biological tissues. Nevertheless, these systems are essentially limited to the delivery of hydrophilic drugs. Our approach for extended release of hydrophobic drugs is to design composite materials composed of lipid nanoparticles (LNPs) entrapped within polysaccharide hydrogels. We selected two polysaccharides which are currently used in pharmaceutical and biomedical applications: carboxymethylcellulose (CMC) and chitosan (CS). We also used poly(ethylene glycol) (PEG) as a plasticizer to tune the matrix mechanical properties. Three types of LNP-loaded hybrid materials were studied; i) bulk CMC/PEG hydrogels, ii) CS/PEG films, and iii) CS/PEG sponges. These materials were chemically crosslinked through attractive click reactions. LNPs were successfully entrapped within the three materials without affecting their properties. A deeper study was conducted with the CMC/PEG composite hydrogel. The LNP release profiles were correlated with the network structure and particles properties. The different materials appear promising systems for the time-controlled delivery of therapeutics
Delorme, Victor. "Nouveaux systèmes copolymères amphiphiles biodégradables pour la délivrance de principes actifs anticancéreux". Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS140.
Pełny tekst źródłaThis work presents the synthesis of biocompatible and biodegradable amphiphilic copolymers for the formation of anticancer drug delivery systems. These copolymers consist of a poly-(ε-caprolactone) (PCL) chain, a biocompatible and biodegradable hydrophobic polyester, on which hydrophilic oligomers of dextrane or chitosane are grafted. These new copolymer structures are called “reverse” structures, the “classic” ones being made of a polysaccharide chain with PCL grafts. The PCL chain was propargylated via an anionic method developed by our team, while azide functions were grafted on oligosaccharides at a chain end of dextrane, but along the chain in chitosan, thanks to its amine functions. Copolymers were obtained by CuAAC click coupling between the activated PCL and oligosaccharides. In the case of chitosan, the amines of the chain allowed the coupling of mannose squarate, a cancer cell targeting agent, as well as a functionalization in the form of thiols which allow coupling by thiol-yne reaction on propargylated PCL. These copolymers form nano objects in aqueous media which, in the case of the PCL-g-dextrane structure, are forming micelles that encapsulate doxorubicin, which is further released in a pH- dependent way. Biological studies have shown that these charged micelles are toxic to cancer cells and not to healthy cells and are preferentially internalized by cancer cells. These results demonstrate a high degree of selectivity of action against tumor cells
Philippe, Isabelle. "Liberation controlee de principes actifs a partir de matrices hydrophiles". Strasbourg 1, 1990. http://www.theses.fr/1990STR15031.
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