Rozprawy doktorskie na temat „Marine sponges”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Sprawdź 50 najlepszych rozpraw doktorskich naukowych na temat „Marine sponges”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Przeglądaj rozprawy doktorskie z różnych dziedzin i twórz odpowiednie bibliografie.
Kalaitzis, John Alexander. "Chemical Investigations of Australian Marine Sponges". Thesis, Griffith University, 2005. http://hdl.handle.net/10072/365493.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Eskitis Institute for Cell and Molecular Therapies
Full Text
Mokhlesi, Amin [Verfasser]. "Natural Products from Marine Sponges / Amin Mokhlesi". Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1154306984/34.
Pełny tekst źródłaPark, Young Chul. "Chemical Investigation of Three Antarctic Marine Sponges". Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/1190.
Pełny tekst źródłaGautschi, Jeffrey T. "Marine natural products from sponges and deep water, marine-derived fungi /". Diss., Digital Dissertations Database. Restricted to UC campuses, 2006. http://uclibs.org/PID/11984.
Pełny tekst źródłaRoper, Kathrein Elizabeth. "Cellular and molecular targets of allelochemicals from marine sponges /". [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19101.pdf.
Pełny tekst źródłaTabudravu, Jioji N. "Investigations of secondary metabolites from Fijian marine sponges". Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602042.
Pełny tekst źródłaSchmidt, Eric Whitney. "Marine sponges and symbionts : chemical and biological studies /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p3035433.
Pełny tekst źródłaBASSOTTI, ELISA. "Heavy metals in marine organisms. Mediterranean and Antarctic marine sponges and bivalves". Doctoral thesis, Università Politecnica delle Marche, 2010. http://hdl.handle.net/11566/242161.
Pełny tekst źródłaKim, Tae Kyung. "Bioactive compound-producing symbiotic bacteria from marine sponge species : cultural, gene retrieval, and metagenomic studies /". [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19506.pdf.
Pełny tekst źródłaAntunes, Edith Martins. "Pyrroloiminoquinone metabolites from South African Latrunculid sponges". Thesis, Rhodes University, 2003. http://eprints.ru.ac.za/215/.
Pełny tekst źródłaSegraves, Nathaniel Lee. "Chemical investigation of biologically active alkaloids from marine sponges /". Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.
Pełny tekst źródłaMani, Luke. "Antiplasmodial compounds from marine sponges of the Solomon Islands". Toulouse 3, 2010. http://www.theses.fr/2010TOU30280.
Pełny tekst źródłaIn a search for new antiplasmodial compounds, one Haliclona and four Aplysina ianthelliformis sponges were chemically investigated to furnish 21 compounds, seven of which are novel ones 141-147. The Haliclona sponge gave the known product, haliclonacylamine A 129 which exhibits potent in vitro activity against the chloroquine-resistant strain, Plasmodium falciparum FCB-1 with an IC50 of 98 nM and a strong selectivity index of 57 and 67 (determined as antiplasmodial activity/ cytotoxicity). In the in vivo mice model, haliclonacyclamine A 129 gave 45% parasitaemia inhibition on the fourth day following three days of treatment at 10 mg/Kg/day administered intra-peritoneally to Swiss female mice infected with P. Vinckei petteri. The A. Ianthelliformis sponges furnished 20 compounds, all but two (aureol 137 and aplysterol 138) of which are bromotyrosine derivatives. All bromotyrosine-derived compounds; 35a, 36, 130-147 exhibit mild in vitro activities against the chloroquine-resistant and sensitive strains, P. Falciparum FCB-1 and 3D7 respectively, with IC50s ranging between 0. 9 – 50. 5 µM. All bromotyrosine compounds lack selectivity except for araplysillin I 139 which has a weak selectivity index of 5. 5 and 6. 5 (measured for MCF-7 and Vero cells respectively) and an IC50 value of 4. 5 µM against P. Falciparum, FCB-1. All bromotyrosine derivatives, except for the novel compound 144, also exhibit weak Protein farnesyltransferase (PFTase) inhibitory activity; the most active, aerophobin II 135, has an IC50 of 8. 0 µM. The inactivity of compound 144 suggests the importance of the isoxazoline motif in conferring PFTase activity in bromotyrosine compounds
Romeril, Stuart P. "Synthesis and structural elucidation of the Bis-3-alkylpyridine alkaloid pyrinodemin A and other monomeric alkaloids". Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288526.
Pełny tekst źródłaLópez, Acosta María. "Silicon consumption by marine sponges: an empirical approach and its ecological implications". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663476.
Pełny tekst źródłaEl silicio (Si), en su forma disuelta de ácido silícico (DSi), es un nutriente clave en el océano. Su disponibilidad en los ecosistemas marinos la regulan varios grupos de organismos, los cuales consumen DSi para construir sus esqueletos de sílice (BSi). Debido a que las diatomeas son el consumidor de Si más abundante, los intentos por cuantificar el uso del Si en el océano se han centrado principalmente en estos organismos, considerando el papel de los otros usuarios de Si como irrelevante. Durante las últimas décadas, algunos estudios han sugerido que al menos otro grupo, las esponjas silíceas, también están jugando un papel no-despreciable en el consumo de Si en los ecosistemas marinos. Las esponjas marinas son animales abundantes en los ecosistemas bentónicos. Es sorprendente que, pese a que el 80% de las especies necesitan DSi para formar sus esqueletos, casi no existe información disponible sobre cómo las esponjas consume dicho nutriente. De hecho, antes del comienzo de esta tesis (inicios del 2014), solo unos pocos estudios habían investigado el consumo de DSi en esponjas marinas, con modelos cinéticos sólo disponibles para dos géneros de demosponjas. Así, el principal objetivo de este trabajo fue mejorar el conocimiento general de cómo las esponjas utilizan DSi, facilitando futuras cuantificaciones del papel de las esponjas como usuarias de Si. Primero, investigamos las cinéticas de consumo de DSi en cinco especies de esponjas, incluida, por primera vez, una especie de la Clase Hexactinellida. También examinamos las fuentes de variabilidad entre especies y entre individuos, detectando que en algunas especies pueden ocurrir cambios estacionales en las cinéticas de consumo. Además, determinamos por primera vez la tasa de uso de DSi en esponjas en su hábitat natural (in situ). Los resultados, significativamente concordantes con los estimados por modelos cinéticos obtenidos en el laboratorio, respaldan el uso de incubaciones largas (>24h) en el laboratorio para investigar las cinéticas de consumo de DSi en esponjas. Finalmente, usamos toda la información empíricamente obtenida durante esta tesis para estimar el uso de DSi por parte de una comunidad de esponjas al nivel de ecosistema: la bahía de Brest (Francia). En resumen, este trabajo muestra que las esponjas tienen un papel relevante como usuarios de Si, incluso en un ecosistema somero en donde las diatomeas contribuyen ampliamente a la biomasa fitoplanctónica. Nuestros resultados también indican que el papel de las esponjas en los ecosistemas marinos aumenta junto con la disponibilidad de DSi. Por tanto, se predice que las esponjas jueguen un papel importante como usuarios de Si en hábitats profundos y de latitudes altas, caracterizados por alta disponibilidad de DSi. Todo ello indica que las esponjas silíceas deben ser consideradas como usuarios de DSi si queremos cuantificar de forma precisa el ciclo del Si a través de los ecosistemas marinos.
Yang, Lai Hung. "Antifouling compounds from the marine sponge acanthella cavernosa and its associated microbes /". View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20YANG.
Pełny tekst źródłaLerata, Mookho Sylvia. "Discovery of cytotoxic natural products from South African marine sponges". University of the Western Cape, 2018. http://hdl.handle.net/11394/6447.
Pełny tekst źródłaCancer is a major health problem worldwide and killing millions of people each year. The use of natural products as chemotherapeutic agents is well established, however, many of the currently available drugs are associated with undesirable side effects and high toxicity. Furthermore, the development of drug resistant cancers makes the search for anticancer lead compounds a priority. In this study a library of prefractionated marine sponge extracts was established and used to prioritise samples for isolation of bioactive metabolites. From the generated library, two of the sponges of genera Ircinia sp. and Latrunculid sp. resulted in isolation of furanosesterterpenes (7E,12Z,20Z,18S-variabilin) and pyrroloiminoquinone (tsitsikammamine A and tsitsikammamine N-18 oxime) alkaloids respectively. The structures of these compounds were elucidated by analysis of 1D and 2D NMR data. These compounds displayed moderate to potent cytotoxicity against MCF-7, PC-3, U-87 and HEK-293 cells lines through apoptosis, with lack of selectivity for cancer cell lines.
Griffiths, Sarah Miriam. "Molecular approaches in conservation and ecology research in marine sponges". Thesis, Manchester Metropolitan University, 2018. http://e-space.mmu.ac.uk/620378/.
Pełny tekst źródłaHagos, Selam. "Chemical Investigation of Bioactive Marine Extracts". Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7301.
Pełny tekst źródłaWren, Stephen P. "Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide". Thesis, University of Cambridge, 1995. https://www.repository.cam.ac.uk/handle/1810/271996.
Pełny tekst źródłaBurkhart, Tandace L. "The Search for Novel Sponge genes: Comparative Analysis of Gene Expression in Multiple Sponges". NSUWorks, 2012. http://nsuworks.nova.edu/occ_stuetd/194.
Pełny tekst źródłaFirkin, Catherine R. "A biomimetic approach to the synthesis of xestospongin A". Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389208.
Pełny tekst źródłaMcMurray, Steven E. "Demography of the giant barrel sponge Xestospongia muta in the Florida Keys". View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/r1/mcmurrays/stevenmcmurray.pdf.
Pełny tekst źródłaTuron, Rodrigo Marta. "Macro- and micro -symbioses involving sponges: Ecological roles in the marine benthos". Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/668685.
Pełny tekst źródłaLa vida en simbiosi representa una contribució fonamental a la diversitat dels ecosistemes marins. Les esponges són models ideals per l’estudi de les relacions simbiòtiques des del punt de vista evolutiu i ecològic, ja que són els metazous més antics de la Terra, són ubiqüistes al bentos marí, i estableixen simbiosis complexes amb procariotes i animals, que al seu torn, contenen les seves pròpies comunitats bacterianes. En aquesta tesis, volem aprofundir en els mecanismes pels quals les esponges estableixen associacions amb membres dels tres dominis de vida, combinant eines taxonòmiques, ecològiques i moleculars. Estudiem com les esponges adquireixen els seus microbis simbionts i com aquests microbis contribueixen a modelar la distribució ecològica de les esponges. A més, utilitzem la relació esponja-poliquet com a exemple de simbiosis multi-organisme i estudiem les associacions eucariotes des de un punt de vista microbià. Finalment, ens centrem en el domini de vida menys estudiat, les arqueas, per aprofundir en la composició i estabilitat d’aquests simbionts en esponges. Per assolir aquests objectius, vam caracteritzar els grups d’esponges de dos ambients diferenciats (impactat i ben preservat) de la badia de Nha Trang (Vietnam), i vam seleccionar les espècies més abundants per l’estudi del seu microbioma. Addicionalment, vam mostrejar quatre espècies d’esponges que contenien milers de poliquets per l’anàlisi de les relacions esponja-microbis-poliquets. Els nostres resultats mostren que les comunitats d’esponges eren més riques i diverses en els ambients ben preservats, i els seus microbiomes mostraven variables ecològiques similars, en els dos tipus d’ambients. La majoria de simbiosis estudiades mostraven una gran especificitat i estabilitat, independentment de l’ambient on vivia l’esponja. El gran solapament entre els bacteris de l’aigua i de l’esponja suggereix que hi ha adquisició microbiana de l’ambient. De forma similar, els poliquets també eren capaços d’adquirir específicament bacteris de les esponges de les quals s’alimentaven. En resum, la majoria de seqüències microbianes eren compartides entre els tres habitats estudiats (aigua/esponge/poliquet), però a diferents abundàncies, donant lloc a microbiomes específics i estables adquirits de l’ambient en els dos grups d’invertebrats estudiats .
Rubio, Brent Kawika. "Bioactive natural products for global health from Papua New Guinea marine sponges /". Diss., Digital Dissertations Database. Restricted to UC campuses, 2008. http://uclibs.org/PID/11984.
Pełny tekst źródłaKhokhar, Shahan. "Chemical Investigations of Australian Marine Sponges Using Experimental and Theoretical NMR Spectroscopy". Thesis, Griffith University, 2015. http://hdl.handle.net/10072/367252.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
Habener, Leesa. "Investigating and comparing chemical and biological variation of marine sponges (phylum Porifera)". Thesis, Griffith University, 2018. http://hdl.handle.net/10072/382720.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environment and Sc
Science, Environment, Engineering and Technology
Full Text
Hanekom, Thea. "Screening bacterial symbionts of marine invertebrates for ribosomally synthesized natural products". University of the Western Cape, 2016. http://hdl.handle.net/11394/5441.
Pełny tekst źródłaPharmaceutical research and development strategies rely on the constant discovery of novel natural products as potential drugs. Recent studies have shown that the microorganisms associated with sponges are the true producers of some previously isolated compounds. This study created a large collection of bacterial symbionts associated with the South African marine sponge, Hamacantha esperioides. The bioactivity assays performed, showed that 44 isolates produced compounds with antimicrobial or anti-inflammatory activity. The successful identification of novel species that produce potential natural products highlights the importance of cultivation-dependent methods. To further screen for natural products, a cultivation-independent approach was used. A sequenced-based method, based on the biosynthetic genes of polytheonamide, was developed to screen for proteusins in sponge metagenomic DNA and the genomes of bacterial symbionts. The degenerate primers could amplify the targeted genes from DNA known to contain homologues. Evaluation of the primers' specificity showed non-specific amplification of genes, some containing similar conserved domains as the target genes. This study demonstrated that the use and development of cultivation-dependent and -independent screens are important for the discovery of novel natural products from the symbiotic bacteria of South African sponges.
National Research Foundation (NRF)
Matobole, Relebohile Matthew. "Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria". University of the Western Cape, 2015. http://hdl.handle.net/11394/4754.
Pełny tekst źródłaThe discovery of novel secondary metabolites has declined significantly in recent years whereas there is a rise in the number of multi-drug resistant pathogens and other types of diseases. The decline in natural product discovery was due to high rediscovery of already known compounds and the costs in developing natural products. As a result pharmaceutical companies lost interest in investing in natural product discovery. However, there is a renewed interest in marine sponge associated microorganisms as a rich and untapped source of secondary metabolites. The objective of this study was to design a matrix to investigate the extent to which the One Strain-Many Compounds (OSMAC) approach applies to a collection of marine sponge isolates harvested from two South African marine sponge samples. Terminal restriction fragment length polymorphisms (T-RFLP) analysis was used to investigate and ascertain the two marine sponges which hosted the highest microbial diversities to be used for further culture-dependent studies. The culture-dependent studies, using 33 media which included liquid enrichment, heat treatments and antibiotic treatments, resulted in 400 sponge isolates from the two marine sponges Isodictya compressa and Higginsia bidentifera. Using antibacterial overlay assays, 31 dereplicated isolates showed antibacterial activity. Bioactivities were also exhibited against E. coli 1699 which is genetically engineered for resistance against 52 antibiotics which implies that some of the bioactive compounds could be novel. The 16S rRNA gene sequences revealed that the microbial phyla isolated from the marine sponges belonged to Actinobacteria, Firmicutes and Proteobacteria (Alphaproteobacteria and Gammaproteobacteria).Thirty isolates were selected for an OSMAC-based matrix study, 17 of which showed noantibacterial activities in preliminary screening. The application of the OSMAC approach using co-culture and 36 culture conditions resulted in 6 isolates showing antibacterial activities, three of which did not show activities in preliminary screening. One of these, a Bacillus pumilus isolated from I. compressa displayed antibacterial activity against 5 indicator strains whereas in preliminary screening it had not shown activity. The results show that marine sponges can host novel microbial species which may produce novel bioactive compounds. The results also confirm that traditional methods employing a single culture condition restricts the expression of some biosynthetic pathways of microorganisms and as a result many metabolites have yet to be identified.
Crowe, Stacie E. "Abundance and Distribution of Commensal Amphipods From Common Marine Sponges of Southeast Florida". NSUWorks, 2001. http://nsuworks.nova.edu/occ_stuetd/306.
Pełny tekst źródłaDaletos, Georgios [Verfasser]. "Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Marine Sponges / Georgios Daletos". Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1101693908/34.
Pełny tekst źródłaHatton, Christopher Martin. "Exploring marine sponges as a source of novel chemical entities for drug development". Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/74792/.
Pełny tekst źródłaWegerski, Christopher John. "Chemistry under the sea : secondary metabolites from marine sponges of Papua New Guinea /". Diss., Digital Dissertations Database. Restricted to UC campuses, 2007. http://uclibs.org/PID/11984.
Pełny tekst źródłaMohamed, Naglaa M. "Ecophysiology of microbial communities associated with marine sponges (Ircinia strobilina) and (Mycale laxissima)". College Park, Md.: University of Maryland, 2007. http://hdl.handle.net/1903/7722.
Pełny tekst źródłaThesis research directed by: Marine, Estuarine, Environmental Sciences Graduate Program. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Spring, David R. "Studies on the biomimetic synthesis of the manzamine alkaloids". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268166.
Pełny tekst źródłaWatson, Daniel John. "Studies directed towards the total asymmetric synthesis of Altohyrtin A". Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364263.
Pełny tekst źródłaCebrian, Pujol Emma. "Sublethal effects of heavy metal contamination on marine sponges: Responses at different biological levels". Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/805.
Pełny tekst źródłaTÍTOL DE LA TESI: "Efectes subletals de la contaminació per metalls pesats en esponges marines: Respostes a diferents nivells d'organització".
TEXT:
Moltes activitats antròpiques alliberen contaminants en el medi. Entre els contaminants hem de destacar els metalls pesants, ja que són contaminants conservatius y que s'acumulen a través de les xarxes tròfiques. En alguns casos la alliberació dels contaminants en el medi es dona de forma aguda i dràstica, el què pot provovar mortalitats massives. De totes formes, de forma general l'alliberació al medi dels metalls pesants es dóna a baixes concentracions i de forma crónica. L'objectiu principal d'aquesta tesis és analitzar les respostes de les esponges a concentracions subletals de metalls pesants i determinar la seva utilitat com a biomonitors d'aquest tipus de contaminació. En primer lloc, s'ha d'estudiar la capacitat de les esponges per acumular metalls pesants tant a una escala temporal com espaial. En segon lloc, mitjançant l'ús de diferents biomarcadors, analitzar els efectes subletals dels metalls en les esponges, a diferents nivells d'organització biológica, desde les molècules fins a les poblacions. Aquesta tesis s'ha dut a terme mitjançant experiments que convinen aproximacions in situ i en el laboratori per tal de compendre de millor maners els models d'acumulació i els seus efectes en funció de l'espècie i el metall considerat.
Callahan, Michael K. "Distribution of clionid sponges in the Florida Keys National Marine Sanctuary (FKNMS), 2001-2003". [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001017.
Pełny tekst źródłaSwasono, Respati Tri. "Bioactive secondary metabolites from Australian invertebrates, Indonesian marine sponges, and an Indonesian terrestrial plant /". [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19275.pdf.
Pełny tekst źródłaAbualreesh, Heba. "Screening for antibacterial metabolites in marine sponges collected from the coastline of Sri Lanka". Thesis, Uppsala universitet, Farmakognosi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-451690.
Pełny tekst źródłaMAZZELLA, VALERIO. "Microbiome, metabolic and phenotypic traits in the adaptability of marine sponges to Ocean Acidification". Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/291001.
Pełny tekst źródłaThe progressive increase of CO2 emissions into the atmosphere due to anthropogenic activities and the consequent absorption by the oceans are causing important changes in the carbonate chemistry of the seawater and a lowering of its pH. This phenomenon, known as Ocean Acidification, is expected to lead to profound changes in the biodiversity and functioning of marine ecosystems in the next decades. In this context, calcifying organisms are predicted to be severely threatened, while non-calcifying or photosynthetic organisms are forecasted as “winners” in future acidified scenarios. Among non-calcifying organisms, marine sponges can be one of the “winners”. They belong to the phylum Porifera, which is widespread in the marine environments, and are characterized by simple anatomical structures and constitutes one of the oldest sessile taxa. These organisms are of paramount relevance in benthic communities for their capability to recycle nutrients, for their rich associated microbiomes, representing model holobiont systems, and for their metabolic versatility and secondary metabolite production. In this dissertation four Mediterranean sponge species (i.e. Petrosia ficiformis, Chondrosia reniformis, Crambe crambe and Chondrilla nucula) have been selected to conduct an in situ investigation to evaluate adaptation traits to ocean acidification. The experimental work took place along the volcanic CO2 vents off Ischia island, which mimic the lowered pH conditions predicted for the end of this century. The aims of this study included: the investigation of sponges’ distribution across acidified and control sites, and the assessment of acclimatization responses in the morphology, associated microbiomes and metabolomic profiles. The outcomes of this thesis highlight species-specific responses. In general, no morphological traits were found to change in acidified versus control conditions. P. ficiformis and C. crambe revealed changes in their associated microbiomes across the pH gradient, while C. reniformis and C. nucula showed more stable microbiomes. Metabolomics signatures, investigated in P. ficiformis and C. crambe, revealed differences both in primary and secondary metabolites between specimens of P. ficiformis inhabiting acidified and control sites, while slight differences only in primary metabolites were observed for C. crambe across sites. Marine sponges seem to be generally tolerant to ocean acidification, and capable to thrive in extreme conditions. This is the first study investigating the microbiome and metabolome of marine sponges under OA with an in situ approach.
Hassanzada, Caidra Elizabeth. "Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges". NSUWorks, 2015. http://nsuworks.nova.edu/occ_stuetd/390.
Pełny tekst źródłaLira, Simone Possedente de. "\"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\"". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-05062007-112443/.
Pełny tekst źródłaIn this work we report the chemical investigation of bioactive crude extracts obtained from four sponges and two fungal strains of marine origin. The crude extracts of three sponges species (Petromica ciocalyptoides, Topsentia ophiraphidites and Callyspongia sp.) displayed inhibitory activity towards the enzyme adenine fosforribosyl transferase of Leishmania tarentolae (L-APRT). Four compounds have been isolated from these extracts: the known halistanol sulfate was isolated of sponges P. ciocalyptoides and T. ophiraphidites, while the novel ilhabelanol, ilhabrene and isoakaterpin have been isolated from the sponge Callyspongia sp. All compounds exhibited inhibition of L-APRT at micro M concentrations. Two coumarin derivatives have been isolated from the crude extract of the sponge Axinella cf. corrugata, probably as artifacts of isolation: esculetin-4-carboxylic acid methyl ester and esculetin-4-carboxylic acid ethyl ester. While the crude extract of the sponge Axinella cf. corrugata presented cytotoxic activity, the pure compounds were inactive in these assays. The esculetin-4-carboxylic acid ethyl ester was found to be an in vitro inhibitor of SARS virus. The crude extract obtained of a marine-derived Beauveria felina strain, isolated from the alga Caulerpa sp., displayed antituberculosis activity against Mycobacterium tuberculosis H37Rv and cytotoxic activity against MCF-7 (breast), HCT-8 (colon) and B16 (murine melanoma) cancer cell lines. Chemical fractionation of the crude extract led to the isolation of two new cyclodepsipeptides pseudodestruxin C and [Beta-Me-Pro] destruxin E chlorohydrin, and of the known destruxin E chlorohydrin, [Phe3, N-Me-Val5] destruxin B, roseotoxin B, roseocardin, isariin and isariin B. The depsipeptides [Phe3, NMe- Val5] destruxin B and rosetoxin B, have been tested against M. tuberculosis H37 Rv and in cytotoxicity bioassays against SF 295 (human CNS) MDA-MB435 (human breast) HCT8 (colon) and HL60 (leukemia) cancer cell lines. Only roseotoxin B displayed moderate cytotoxicity against the cancer cell lines.
Hedner, Erik. "Bioactive Compounds in the Chemical Defence of Marine Sponges : Structure-Activity Relationships and Pharmacological Targets". Doctoral thesis, Uppsala University, Division of Pharmacognosy, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8218.
Pełny tekst źródłaMarine invertebrates, in particular sponges, represent a source of a wide range of secondary metabolites, many of which have been attributed various defensive capabilities against environmental stress factors. In this thesis sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets.
The compound bromobenzisoxazolone barettin (cyclo[(6-bromo-8-(6-bromo-benzioxazol -3(1H)-one)-8-hydroxy)tryptophan)]arginine) was isolated from the sponge Geodia barretti and its ability to inhibit larval settlement of the barnacle Balanus improvisus was determined. With an EC50 value of 15 nM, this compound’s antifouling effect was higher than those of the previously reported brominated dipeptides from Geodia barretti, i.e., barettin and 8,9-dihydrobarettin; moreover, this antifouling effect was demonstrated to be reversible. However, the compound lacked affinity for 5-HT1-7 receptors, whereas barettin possessed specific affinity to 5-HT2A, 5-HT2C and 5-HT4, while 8,9-dihydrobarettin interacted with 5-HT4. In an attempt to evaluate structure-activity relationships synthesized analogs with barettin and dipodazine scaffolds were investigated for antifouling activity. The analog benso[g]dipodazine, with an EC50 value of 34 nM, displayed the highest settlement inhibition.
The studies of the structure-activity relationships of sponge-derived compounds were extended to cover analogs of agelasines and agelasimines originally isolated from sponges of the genus Agelas. Synthesized (+)-agelasine D and two structurally close analogs were investigated for cytotoxic and antibacterial activity. The profound cytotoxicity and broad spectrum antibacterial activity found prompted a further investigation of structure-activity relationships in 42 agelasine and agelasimine analogs and several characteristics that increased bioactivity were identified.
In conclusion this work has produced new results regarding the potent bioactivity of compounds derived from the sponges Geodia barretti and Agelas spp. and increased SAR knowledge of the fouling inhibition, cytotoxicity and antimicrobial activity of these compounds.
Höller, Ulrich. "Isolation, biological activity and secondary metabolite investigations of marine-derived fungi and selected host sponges". [S.l.] : [s.n.], 1999. http://www.gbv.de/dms/bs/toc/271061243.pdf.
Pełny tekst źródłaPimentel, Elardo Sheila Marie. "Novel anti-infective secondary metabolites and biosynthetic gene clusters from actinomycetes associated with marine sponges". Doctoral thesis, kostenfrei, 2008. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-40463.
Pełny tekst źródłaZahlreiche marine Schwämme (Phylum: Porifera) beherbergen eine phylogenetisch diverse mikrobielle Gemeinschaft in der Mesohyl-Matrix, darunter auch viele Vertreter des bakteriellen Phylums Actinobacteria, die umgangssprachlich als Actinomyceten bekannt sind. Actinomyceten sind wichtige Produzenten vieler Antibiotika und von weiteren pharmazeutisch relevanten Substanzen. Das Hauptziel dieser Promotionsarbeit war die Untersuchung des Potentials Schwamm-assoziierter Actinomyceten zur Produktion neuer Infektions-hemmender Substanzen. Ein erstes Ziel dieser Doktorarbeit war die Kultivierung von Actinomyceten aus verschiedenen marinen Schwammarten. Die Sequenzierung der respektiven 16S rRNA Gene zeigte eine phylogenetische Zugehörigkeit der Isolate zu verschiedenen Actinomyceten-Familien, wie Gordonia, Isoptericola, Micromonospora, Nocardiopsis, Saccharopolyspora und Streptomyces. Durch phylogenetische Analysen und umfangreiche taxonomische Charakterisierungen konnten zwei neue Actinomyceten-Arten, Saccharopolyspora cebuensis strain SPE 10-1T (Pimentel-Elardo et al. 2008a) und Streptomyces axinellae strain Pol001T (Pimentel-Elardo et al. 2008b) beschrieben werden. Des Weiteren sollten die Actinomyceten-Isolate auf die Produktion von Sekundär-Metaboliten hin untersucht werden. Die Substanzen wurden „bioassay-guided“ aufgereinigt und isoliert sowie deren Struktur mittels spektroskopischer Methoden aufgeklärt. Anschließend wurden die Substanzen ausführlichen Screening-Methoden unterzogen, um sie auf anti-infektive Wirkungen hin zu untersuchen. Zahlreiche interessante Verbindungen konnten so isoliert werden, u. a. die neuen Polyketide Cebulactam A1 und A2 (Pimentel-Elardo et al. 2008c); eine Familie von Tetromycin-Substanzen inklusive neuartiger Derivative; das Cyclodepsipeptid Valinomycin, Indolocarbazole Staurosporine, Diketopiperazine Cycloisoleucylprolyl und Butenolide. Die Verbindungen zeigten signifikante anti-parasitische und Protease-hemmende Aktivitäten. Das dritte Ziel dieser Arbeit war es, die für nicht-ribosomale Peptidsynthetasen (NRPS) und Polyketidsynthasen (PKS) kodierenden, biosynthetischen Gen-Cluster in den Actinomyceten-Isolaten zu identifizieren. Die Konstruktion von Genbanken sowie die Sequenzierung ausgewählter Cosmidklone lieferte erste Einblicke in das Stoffwechsel- und Biosynthesepotential ausgewählter Isolate. Beispielsweise konnte ein interessantes NRPS-System in Streptomyces sp. Stamm Aer003 identifiziert werden, welches in verschiedenen Schwammarten, einer Ascidienart sowie im Meerwasser gefunden wurde. Die Sequenzierung eines PKS-Genclusters aus Saccharopolyspora cebuensis strain SPE 10-1T ermöglicht die Voraussage des Cebulactam-Biosynthesewegs in dem 3-Amino-5-Hydroxybenzoesäure als Ausgangsprodukt dient, welches durch sukzessive Kondensationsschritte sowie Verlängerungen durch Methylmalonyl- und Zusatzdomänen zum endgültigen Polyketid führen. Zusammenfassend konnte in dieser Promotionsarbeit gezeigt werden, dass marine Schwämme mit diversen Vertretern aus verschiedenen Familien der Actinomyceten assoziiert sind. Die Bakterienisolate, von denen zwei neue Arten repräsentieren, produzierten mehrere chemische Substanzen mit interessanten anti-infektiven Eigenschaften. Des Weiteren konnte mit dieser Arbeit durch die Identifizierung von Biosynthese-Genclustern das Potential von Actinomyceten zur Produktion verwertbarer bioaktiver Substanzen bekräftigt und somit ein Beitrag zur Entdeckung neuer anti-infektiver Substanzen erbracht werden
Tucker, David John, i n/a. "An Investigation of the Chemical Constituents of Two Species of Marine Sponge". Griffith University. Division of Science and Technology, 1990. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050826.155059.
Pełny tekst źródłaTucker, David John. "An Investigation of the Chemical Constituents of Two Species of Marine Sponge". Thesis, Griffith University, 1990. http://hdl.handle.net/10072/367459.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Division of Science and Technology
Full Text
Knestrick, Matthew A. "From Florida to Antarctica: Dereplication Strategies and Chemical Investigations of Marine Organisms". Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7635.
Pełny tekst źródłaIsmail, Noraznawati. "Interactions between sponges and marine bacteria as a route to the discovery of novel bioactive compounds". Thesis, Heriot-Watt University, 2006. http://hdl.handle.net/10399/2076.
Pełny tekst źródłaMcQuillan, Lea. "Species richness, density and cover of sponge assemblages on temperate reefs off Perth, Western Australia". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2006. https://ro.ecu.edu.au/theses/359.
Pełny tekst źródła