Gotowe bibliografie tematyczne / Marine drugs

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Gotowa bibliografia na temat „Marine drugs”

Autor: Grafiati
Data publikacji: 6 września 2023

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Artykuły w czasopismach na temat "Marine drugs"

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Lu, Xiao-Ling, Qiang-Zhi Xu, Xiao-Yu Liu, Xin Cao, Kun-Yi Ni i Bing-Hua Jiao. "Marine Drugs - Macrolactins". Chemistry & Biodiversity 5, nr 9 (24.09.2008): 1669–74. http://dx.doi.org/10.1002/cbdv.200890155.

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Gallo, Carmela, i Genoveffa Nuzzo. "Drugs from Marine Sources". Applied Sciences 11, nr 24 (20.12.2021): 12115. http://dx.doi.org/10.3390/app112412115.

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Guan, Hua-Shi. "The Journal Marine Drugs and the First International Symposium on Marine Drugs (2004)". Marine Drugs 1, nr 1 (15.11.2003): 3–4. http://dx.doi.org/10.3390/md101003.

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Farooqi, Ammad, Sundas Fayyaz, Ming-Feng Hou, Kun-Tzu Li, Jen-Yang Tang i Hsueh-Wei Chang. "Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs". Marine Drugs 12, nr 11 (13.11.2014): 5408–24. http://dx.doi.org/10.3390/md12115408.

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Javed, Faraza, M. Imran Qadir, Khalid Hussain Janbaz i Muhammad Ali. "Novel drugs from marine microorganisms". Critical Reviews in Microbiology 37, nr 3 (20.05.2011): 245–49. http://dx.doi.org/10.3109/1040841x.2011.576234.

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Shikov, Alexander N., Elena V. Flisyuk, Ekaterina D. Obluchinskaya i Olga N. Pozharitskaya. "Pharmacokinetics of Marine-Derived Drugs". Marine Drugs 18, nr 11 (9.11.2020): 557. http://dx.doi.org/10.3390/md18110557.

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Marine organisms represent an excellent source of innovative compounds that have the potential for the development of new drugs. The pharmacokinetics of marine drugs has attracted increasing interest in recent decades due to its effective and potential contribution to the selection of rational dosage recommendations and the optimal use of the therapeutic arsenal. In general, pharmacokinetics studies how drugs change after administration via the processes of absorption, distribution, metabolism, and excretion (ADME). This review provides a summary of the pharmacokinetics studies of marine-derived active compounds, with a particular focus on their ADME. The pharmacokinetics of compounds derived from algae, crustaceans, sea cucumber, fungus, sea urchins, sponges, mollusks, tunicate, and bryozoan is discussed, and the pharmacokinetics data in human experiments are analyzed. In-depth characterization using pharmacokinetics is useful for obtaining information for understanding the molecular basis of pharmacological activity, for correct doses and treatment schemes selection, and for more effective drug application. Thus, an increase in pharmacokinetic research on marine-derived compounds is expected in the near future.
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Belarbi, E. "Producing drugs from marine sponges". Biotechnology Advances 21, nr 7 (październik 2003): 585–98. http://dx.doi.org/10.1016/s0734-9750(03)00100-9.

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Grosso, Clara, Patrícia Valentão, Federico Ferreres i Paula Andrade. "Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases". Marine Drugs 12, nr 5 (2.05.2014): 2539–89. http://dx.doi.org/10.3390/md12052539.

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Russo, Patrizia, i Alfredo Cesario. "New Anticancer Drugs from Marine Cyanobacteria". Current Drug Targets 13, nr 8 (1.06.2012): 1048–53. http://dx.doi.org/10.2174/138945012802009035.

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De, Oindrila, i Biswa P. Chatterji. "Marine Derived Anticancer Drugs Targeting Microtubule". Recent Patents on Anti-Cancer Drug Discovery 12, nr 2 (5.06.2017): 102–27. http://dx.doi.org/10.2174/1574892812666170109141003.

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Rozprawy doktorskie na temat "Marine drugs"

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Bannerman-Akwei, Laude. "Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs". Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1990.

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Two natural marine compounds, 3-bromo-4,5-dihydroxybenzaldehyde 2 and 2,3-dibromo-4,5-dihydroxybenzaldehyde 5 together with two novel derivatives, 3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxybenzaldehyde 3 and 1-bromo-2,3-dimethoxy-5-nitrooxy-methylbenzene 9, were synthesized. Compounds 2, 3, and 5 were evaluated for their biological activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound 9 is yet to be evaluated.
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Lane, Amy L. "Marine natural products as antimicrobial chemical defenses and sources of potential drugs". Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26556.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.
Committee Chair: Kubanek, Julia; Committee Member: Fernandez, Facundo M.; Committee Member: Harvey, Stephen C.; Committee Member: Hay, Mark E.; Committee Member: Hud, Nicholas V. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Sunkel, Vanessa Ann. "The investigation of novel marine microorganisms for the production of biologically active metabolites". Thesis, Rhodes University, 2009. http://hdl.handle.net/10962/d1004579.

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New drugs, particularly antibiotics, are urgently required to combat the increasing problem of antibiotic resistant human pathogens. Due to the scarcity of products available today, the pharmaceutical industry is now under pressure to reassess compounds derived from plants, soil and marine organisms. Pharmaceutical companies are showing renewed interest in marine biotechnology as the oceans represent a rich source of both biological and chemical diversity of novel molecular structures with anti-cancer, anti-inflammatory and antibiotic properties. Formerly unexplored locations, such as deep ocean sediments, show great potential as a source of genetically novel microorganisms producing structurally unique secondary metabolites. In this research, a metabolite producing marine Pseudoalteromonas strain, known as AP5, was initially used to develop methods for the detection, optimisation of production and extraction of bioactive metabolites from other potentially novel marine isolates. Two hundred and seventy six (276) marine isolates from water and sediment samples from the Antarctic Ocean and Marion Island were isolated. Ten visually different isolates were screened for bioactivity against Gram-positive and -negative bacteria, fungi and yeast. Three out of the 10 isolates, WL61 , WL 114 and WL 136, appeared to be novel Streptomyces spp. showing activity against different test organisms. Many of these marine microorganisms are difficult to culture in the laboratory, particularly when they are cultivated continuously in shake flasks as they can stop producing bioactive compounds. The cultivation of marine isolates in bioreactors may be a more beneficial process for the optimisation of metabolite production compared to conventional liquid fermentation techniques whereby the solid-liquid-air interface of membrane bioreactors can imitate the natural environment of microbes. The membrane bioreactor system is a stable growth environment with low shear that supports steady-state biofilm growth consisting of a high cell density due to a high mass transfer of nutrients and oxygen to the cells. This approach was employed and isolates WL61, WL114 and WL136 were immobilised onto ceramic membranes using Quorus single fibre bioreactors (SFR). The SFRs were used to establish the most suitable growth medium for continuous secondary metabolite production. The best growth conditions were applied to the Quorus multifibre bioreactor (MFR) for scale up of biologically active metabolites, highlighting the potential of bioreactor technology for use in bioprospecting for isolating and screening novel and known organisms for new and interesting natural products. Furthermore, the Quorus MFR was shown to be suitable for the production of high yields of antimicrobial metabolites and is an efficient new fermentation production system. Purification by HPLC fractionation was used to characterise four major compounds from isolate WL 114 extracts. NMR structure elucidation identified one of the two primary compounds as Bisphenol A. The complete chemical structure for the second potent bioactive compound could not be determined due to the low concentration and volume of material.
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Watson, Daniel John. "Studies directed towards the total asymmetric synthesis of Altohyrtin A". Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364263.

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Llorach, Parés Laura. "Computer-Aided Drug Design applied to marine drug discovery = Disseny de fàrmacs assistit per ordinador aplicat a la cerca de possibles fàrmacs marins". Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668298.

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The potential of natural products in general, and marine natural products in particular, as pharmacological entities has been widely demonstrated in recent years. Marine benthic ecosystems contain an extraordinary range of diverse organisms that possess bioactive natural compounds, which are commonly used as defensive or protective chemical mechanisms. These effective defensive strategies are based on secondary metabolites that are crucial for the species survival. The pharmacological properties of these unique chemical compounds constitute an interesting and emerging hot research line, based upon exploiting them for the development of new drugs. The evolution, biodiversity, and specific environmental conditions found in marine ecosystems, such as Antarctica and the Mediterranean Sea, make them an amazing source of potential therapeutic agents. Interestingly, some of these natural products are capable to modulate protein functions in pathogenesis-related pathways. The process of discovery and development of new drugs, for instance small molecules, with the aforementioned capacity to modulate protein functions, is a tedious procedure that requires economic resources and time. To reduce these drawbacks, computer-aided drug design (CADD) has emerged as one of the most effective methods. A rapid exploration of the chemical space can be done with computational methods, and they are very interesting and useful complementary approaches to experimental methods. CADD techniques can be applied in different steps of the drug discovery pipeline, and also, can cover several phases of this pipeline. To that end, several objectives have been set and reached in this thesis: 1. To find possible therapeutic activities and to establish the capability to modulate protein functions in pathogenesis-related pathways from marine molecules by using different CADD tools and techniques: I. Improve the drug discovery pipeline by the elucidation of the possible therapeutic potential of a set of marine molecules against a list of targets related to different pathologies. II. Elucidation of different pharmacophoric features of marine compounds and a precise in silico binding study, highlighting the power of CADD techniques, and reporting the inhibitory activity of different natural products and indole scaffold derivatives as GSK3β, CK1δ, DYRK1A, and CLK1 inhibitors. III. Computational study and an experimental validation of meridianins and lignarenones as possible ATP and/or substrate inhibitors of GSK3β. The main conclusions of this thesis are that marine molecules can be used as therapeutic agents against protein kinases related to the AD, and the exemplification of CADD potential applied to marine drug discovery.
El potencial dels productes naturals en general, i els productes naturals marins en particular, com a entitats farmacològiques ha quedat demostrat al llarg dels últims anys. Els ecosistemes bentònics marins contenen una extraordinària diversitat d'organismes que posseeixen compostos naturals bioactius, que utilitzen com mecanismes químics defensius i de protecció. Aquestes efectives estratègies defensives es basen en metabòlits secundaris, crucials per a la supervivència de les espècies. Tenint en compte les propietats farmacològiques d'aquests compostos químics únics, utilitzar-los per al desenvolupament de nous fàrmacs constitueix una línia interessant de recerca emergent. L'evolució, la biodiversitat i les condicions específiques que es troben en els ecosistemes marins, com ara l'Antàrtida i el mar Mediterrani, els converteixen en una font increïble de possibles agents terapèutics, capaços de modular funcions de proteïnes involucrades en determinades patologies. El procés de descobriment i desenvolupament de nous fàrmacs, per exemple, molècules petites, és un procediment tediós que requereix de recursos econòmics i de temps. Per reduir aquests inconvenients, el disseny de fàrmacs assistit per ordinador (DFAO) ha sorgit com un dels mètodes principals i més eficaços. Es pot fer una exploració ràpida de l'espai químic amb mètodes computacionals i a més, són aproximacions complementàries als mètodes experimentals molt interessants i útils. Les tècniques de DFAO es poden aplicar en diferents passos del procés de descobriment de fàrmacs, i també, poden cobrir diverses fases d'aquest pipeline. Amb aquesta finalitat, es varen establir diversos objectius en aquesta tesi: 1. Dilucidar la possible activitat terapèutica i la capacitat per modular les funcions de proteïnes que estan relacionades amb una determinada patologia de les molècules marines mitjançant l'ús de diferents eines i tècniques de DFAO: I. millorar el pipeline de descobriment de fàrmacs mitjançant l'elucidació del possible potencial terapèutic d'un conjunt de molècules marines enfront d'una llista de dianes relacionades amb diferents patologies. II. Dilucidació de les diferents característiques farmacofóriques dels compostos marins i en un precís estudi d’unió in silico, destacant el poder de les tècniques de DFAO, i avaluar l'activitat inhibidora de diferents productes naturals i derivats d’esquelets indòlics com inhibidors de GSK3β, CK1δ, DYRK1A i CLK1. III. Estudi computacional i validació experimental de meridianines i lignarenones com a possibles inhibidors de GSK3β mitjançant la unió a la cavitat de l'ATP i/o del substrat. En relació amb aquests objectius, les conclusions principals d'aquesta tesi són, que les molècules marines poden ser utilitzades com a agents terapèutics contra proteïnes quinases relacionades amb la malaltia d’Alzheimer, i l'exemplificació del potencial de les tècniques de DFAO aplicat al descobriment de fàrmacs marins.
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Mezzelani, Marica. "Ecotoxicological potential of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in marine organisms: bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis". Doctoral thesis, Università Politecnica delle Marche, 2016. http://hdl.handle.net/11566/243116.

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I residui dei composti farmaceutici presenti in ambiente rappresentano una problematica emergente dato che le informazioni riguardo la loro presenza, distribuzione e potenziale ecotossicologico sono molto limitate, specialmente per le aree costiere. In questa tesi è stata valutata la sensibilità del mitilo Mediterraneo Mytilus galloprovincialis nei confronti di diversi farmaci anti infiammatori non steroidei (FANS), applicando un approccio integrato che ha previsto sia attività di laboratorio che indagini di campo. In condizioni di laboratorio i mitili sono stati esposti a diverse concentrazioni ambientalmente realistiche (25, 2.5 e 0.5 μg/L) di acetaminofene AMP, diclofenac DIC, ibuprofene IBU, ketoprofene KET e nimesulide NIM, per diversi tempi di esposizione (da 14 a 60 giorni). Il potenziale ecotossicologico dei FANS è stato valutato combinando le analisi chimiche del bioaccumulo dei farmaci con un approccio multi-biomarker, basato sullo studio di un ampio numero di risposte subcellulari che rappresentano dei segnali di allerta precoce di alterazione cellulare e di tossicità. Per alcune condizioni sperimentali, le alterazioni funzionali misurate a livello cellulare sono state integrate con modificazioni trascrittomiche a livello molecolare attraverso la tecnica di microarray a DNA. I risultati ottenuti hanno dimostrato che i mitili sono in grado di bioaccumulare DIC, IBU e NIM non seguendo, tuttavia, una cinetica dose dipendente, mentre AMP e KET non sono mai stati misurati indipendentemente dalla dose e dal tempo di esposizione. Ciononostante, tutte le molecole testate e tutte le condizioni sperimentali hanno determinato l’insorgenza di alterazioni a carico dei parametri immunitari, modulazione del metabolismo lipidico e danno genotossico. Le analisi trascrittomiche hanno rivelato modificazioni a carico degli organismi esposti alle dosi più basse, sia nel breve (KET e NIM) che nel lungo termine (KET). I risultati ottenuti a livello molecolare supportano le alterazioni misurate a livello cellulare e suggeriscono che il meccanismo di azione dei FANS negli invertebrati risulta essere molto simile a quello ampiamente documentato nei mammiferi. Le indagini a lungo termine hanno permesso di comprendere che l’effetto dei FANS si mantiene costantemente per 60 giorni. Le indagini in campo hanno rivelato, per la prima volta, la presenza di DIC, IBU e NIM nei mitili naturali campionati in primavera e in estate da tipiche aree turistiche del Mare Adriatico centrale. Complessivamente tutti i risultati hanno dimostrato che il M. galloprovincialis è una buona specie sentinella per i FANS, e il reale pericolo ecotossicologico dei farmaci nel Mediterraneo.
Pharmaceuticals represent a major environmental concern since the knowledge on their occurrence, distribution and ecotoxicological potential is still limited particularly in coastal areas. In this thesis the sensitivity of the Mediterranean mussels Mytilus galloprovincialis toward different Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) was assessed, applying an integrated approach which combined laboratory studies with field investigation. In laboratory conditions mussels were exposed to different environmental realistic concentrations (25, 2.5 and 0.5 μg/L) of acetaminophen AMP, diclofenac DIC, ibuprofen IBU, ketoprofen KET and nimesulide NIM, for different periods (from 14 to 60 days). The ecotoxicological potential of NSAIDs was evaluated combining chemical analyses on pharmaceuticals bioaccumulation with a multi-biomarker approach, based on a wide array of molecular and subcellular responses reflecting early warning signals of biological disturbance, modulation of specific cellular pathways, onset of various typologies of cellular damages and toxicity. For some experimental condition, functional alteration at cellular level were further integrated with transcriptomic changes at molecular level using DNA microarray. Obtained results demonstrated that mussels are able to bioconcentrate DIC, IBU and NIM without dose dependent response, while AMP and KET are never detected independently from the doses and the exposure period. Nonetheless, for all tested NSAIDs and in all experimental conditions, measurement of a large panel of ecotoxicological biomarkers highlighted impairment of immunological parameters, modulation of lipid metabolism and genotoxic effects. The analyses on transcriptomic profile highlighted changes at molecular level for organisms exposed to lower doses, both in short (for KET and NIM) and long-term condition (for KET). Molecular results supported changes obtained at cellular level and suggest similar mechanisms of action of NSAIDs in mammals and vertebrates. Long-term responses allowed to determine that the effects of anti-inflammatory pharmaceuticals were constantly maintained over 60 days. Field studies provided the first evidence on the occurrence of DIC, IBU and NIM in tissues of wild mussels sampled during summer and spring periods from typical, touristic areas of Central Adriatic Sea. Overall results demonstrated M. galloprovincialis as a good sentinel species toward anti inflammatory pharmaceuticals and the actual ecotoxicological hazard of pharmaceuticals in the Mediterranean.
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Noor, Humaira. "Immunological Effects of Haliotis Rubra Hemolymph and Hemolymph Components". Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17063.

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Marine derived drugs are emerging with promises to positively intervene in a range of diseases including viral, bacterial, fungal, and to even some forms of cancers. Hemolymph of several molluscs are of particular interest for their immunomodulatory properties that enhance their anti-microbial and anti-cancerous mechanisms. Our research aims to uncover the immunological effects of Haliotis rubra hemolymph, purified hemocyanin and hemolymph permeate. Their immunomodulatory properties can be key to treating Herpes Simplex Virus -1, HSV-1, infected patients and prostate cancer patients. In this study, we cultured HaCat cells and Human oral primary and prostate cancer cell line (PC-3) to observe immunomodulatory effects of the extracts on such form of cancer. Treatment with variable concentrations of abalone sera, purified hemocyanin and the sera/hemolymph were carried out. Results show a 50% inhibition in Interleukin-6 (IL-6) expression, 21% inhibition in Interleukin-8 (IL-8) . There is an observed inhibition of IL-6 expression in permeate, AH and sera treated PC-3. Additionally, the effects also extend to IL-8. The most significant results were obtained for primary oral keratinocytes treatment with the abalone sera yielding a sharp 35 fold increase in IL-8 concentration and 23 fold increase in IL-6 concentration as compared to the untreated control. To summarize: hemolymph, purified hemocyanin and hemolymph permeate targets IL-6 and IL-8 , that will potentially help HSV-1 infected and prostrate cancer patients. Whole hemolymph permeate induces highest degree of cytokine modulation in all cell types. The permeate is found to predominantly consist of hemocyanin fragments of various sizes . Therefore, broken hemocyanin fragments, rather than whole hemocyanin molecule, has greater immunomodulatory properties. HaCat cells do not fit as a model for IL-6 and IL-8 modulation studies, although targeted modulation of these cytokines are also exhibited here on hemolymph treatments.
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Bovio, Elena. "Champignons marins d'éponges marines : biodiversité, chimiodiversité et applications biotechnologiques". Thesis, Université Côte d'Azur (ComUE), 2019. http://theses.univ-cotedazur.fr/2019AZUR4009.

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L'environnement marin est doté d’une diversité fongique encore trop faiblement explorée puisqu’on estime qu’environ 10% des champignons marins ont fait l’objet d’une étude. Dans ce contexte, le projet de thèse décrit dans ce manuscrit est focalisé sur le potentiel biotechnologique des champignons marins isolés d’éponges marines. Ces champignons sont caractérisés par une importante biodiversité et chimiodiversité susceptible de conduire à de nouvelles molécules bioactives. Il s’agit d’un projet pluridisciplinaire qui joint la mycologie, la chimie, la biochimie et les biotechnologies. Il couvre la stratégie complète de découverte de nouveaux produits naturels avec l'isolement et l'identification des souches fongiques à l’extraction et l'isolement des molécules ainsi que l’évaluation des propriétés biologiques. Le manuscrit est divisé en trois parties principales : - La première partie est dédiée à l’isolement des communautés fongiques cultivables associées à quatre éponges de l’océan Atlantique et trois éponges de Méditerranée. Nous avons obtenu au total 129 taxons parmi lesquels 84,5% ont pu être identifiées jusqu’au niveau de l’espèce via une approche polyphasique basée sur des techniques morphologiques, moléculaires et phylogénétiques. Parmi ces derniers, nous avons décrit pour la première fois deux espèces : Thelebolus balaustiformis et Thelebolus spongiae. Nos travaux ont permis de souligner la spécificité des communautés fongiques hébergées par chaque éponge ce qui laisse à penser que les éponges sont capables de recruter leur propre mycobiote. - La seconde partie est consacrée à l'étude de la diversité chimique des champignons marins associés à l'éponge Grantia compressa en utilisant l'approche OSMAC (une souche – de nombreux composés). Les résultats obtenus ont révélé les difficultés à obtenir des conditions de culture optimales. De façon générale et pour tous les champignons, les milieux riches en nutriments favorisent à la fois le développement du mycélium et la production de métabolites secondaires. Parmi les champignons isolés, Eurotium chevalieri MUT 2316 produits de nombreux métabolites, comparativement aux autres champignons. Dans ce contexte, nous avons pu isoler et caractériser dix composés. - La troisième partie est dédiée à l’évaluation des propriétés biologiques (pharmacologiques et environnementales) des différentes molécules isolées. Six composés ont montré des propriétés antibactériennes notamment l'isodihydroauroglaucine qui s’est avérée active vis-à-vis de la plupart des bactéries à Gram-positif testées et pour laquelle une activité bactéricide a pu également être décelée. La dihydroauroglaucine et le physcion inhibent complètement la réplication du virus de la grippe A tandis que la neoechinuline inhibe le virus de l'herpès simplex 1. Enfin, les différentes molécules ont été évaluées pour leurs propriétés antifoulings susceptibles de rentrer dans la composition de peintures plus respectueuses de l’environnement. Les molécules inhibent à de très faibles concentrations l'adhésion et la croissance de bactéries et de microalgues impliquées dans le biofouling. Par ailleurs, la combinaison de molécules isolées d’E. chevalieri MUT 2316 inhibe la totalité des bactéries et microalgues testées. Les travaux menés ont permis de mettre en avant l’importante biodiversité et chimiodiversité de champignons marins hébergés par les éponges. Les molécules isolées d’E. chevalieri MUT 2316 sont susceptibles de valorisation dans différents domaines de recherche tels que le développement de nouveaux médicaments ou de peintures antifoulings plus respectueuses de l’environnement
Marine environment represents an untapped source of fungal diversity, where it has been estimated that about 10% of fungi have been explored until now. Due to the lack of knowledge on marine fungi and their incredible biotechnological potential, this Ph.D. thesis focuses on a highly promising group of fungi: those associated with marine sponges. These fungi are both characterized by high biodiversity and chemodiversity, being the most successful producers of new bioactive molecules. On these premises, the main goal of the research was to cover the firsts and fundamentals aspects of the natural products discovery pipeline: from the isolation and identification of fungi from sponges to the isolation of molecules and the evaluation of their biological activity. This resulted in a multidisciplinary Ph.D. project that enclosed mycology, chemistry, biochemistry and biotechnology. In a “funnel-like” perspective, using multidisciplinary experimental approaches three main parts were developed: - The first aim was to isolate the fungal communities associated with sponges using several isolation techniques to increase the number of cultivable fungi. Four and three sponges were respectively collected in the Atlantic Ocean and in the Mediterranean Sea. Overall, 129 taxa were obtained; thanks to a polyphasic approach based on morphological, molecular and phylogenetic techniques, 84.5% of them were identified at the species level. Two fungal species Thelebolus balaustiformis and Thelebolus spongiae were here first described, updating the knowledge on marine fungal diversity. This work underlined the specificity of the fungal community for each sponge, leading to think that these animals are able to recruit their own mycobiota. - The second part was based on the investigation of the chemical diversity of marine fungi associated with the sponge Grantia compressa, using the OSMAC approach (One Strain – Many Compounds). Not surprisingly, it has been difficult to define a condition that promotes both the development of the mycelium and the secondary metabolites production for all fungi; generally, rich nutrients media are the best candidates to achieve the above-mentioned results. Among the tested fungi, Eurotium chevalieri MUT 2316 produce more metabolites than any other fungus and ten pure compounds were isolated. - The third part of this Ph.D. project aimed to test the biological activity of the ten fungal molecules. Two main research fields, pharmaceutical and environmental, were chosen as potential targets. Six compounds showed antibacterial activity, with isodihydroauroglaucin active against most of the Grampositive bacteria tested also with bactericidal activity. Dihydroauroglaucin and physcion were able to completely inhibit the replication of Influenza A virus, while neoechinulin completely inhibited Herpes Simplex Virus 1. Finally, the last series of bioassays aimed to face the urgent need of environmentally friendly antifouling and highlighted several molecules already active at extremely low concentrations, inhibiting the adhesion and growth of both bacteria and microalgae. As result, a mix of few compounds produced by E. chevalieri MUT 2316 would inhibit all the bacteria and microalgae tested. In conclusion, this Ph.D. project highlighted the outstanding biodiversity and chemodiveristy of marine fungi inhabiting sponges. The molecules isolated from E. chevalieri MUT 2316 found applications in different research fields and represent promising candidates for the development of new drugs and antifouling paints
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Hagos, Selam. "Chemical Investigation of Bioactive Marine Extracts". Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7301.

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Natural products have been a fundamental source of medicinal scaffolds for decades; with sixty percent of marketed drugs. Many synthetic chemists are focused on synthesizing potent and nontoxic compounds for pharmaceutical targets, however, nature is still proving to be a source of new bioactive compounds. Produced by the host organism for defense, reproduction and communication, secondary metabolites also demonstrate promising bioactivity against human pathogens. Hence, natural product chemists continue their quest for new leads. As a continuation of these efforts, this thesis attempts to explore fungi and sponges for new chemistry, and ultimately, new drug candidates. Antarctica is largely untapped; hence herein two Antarctic sponges were chemically investigated. This resulted in isolation and characterization of two metabolites. Concurrently, chemical investigation of fungus, from Floridian mangrove species, resulted in the isolation of two structurally diverse metabolites. Further, a dereplication process was applied to MPLC fractions, which lead to the identification of known metabolites and mycotoxins. This enabled prioritization of fractions for future studies.
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Houssen, Wael E. "Chemical, biological and molecular approaches toward drug discovery from marine organisms". Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439971.

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The first chapter provides a comprehensive review on the current status of drug discovery from the sea, the hurdles encountered and the future trends.  The second chapter describes the use of biologically guided fractionation to isolate cytotoxic compounds from the marine ascidian Sigillina signifera.  The main outcome was the isolation and identification of four known compounds identified as 4-methoxy-2,2’-bipyrrole-5-carboxaldehyde, tambjamine C, tambjamine F and phenyl ethylamine.  The first three compounds were shown to be responsible for the cytotoxicity shown by the crude extract.  The third chapter describes the isolation and identification of a new 4-hydroxybenzoyl derivative from the aqueous extract of the marine hydroid Campanularia sp. using NMR-guided fractionation.  In spite of its structural resemblance to some potent histone deacetylase inhibitors, the new compound has proved to completely lack such activity.  The fourth and fifth chapters describe the use of electrophysiological techniques and Ca2+ imaging to investigate the effects of two compounds on the behaviour of different ion channels expressed on cultured DRG neurones.  The first compound, latrunculin A, was shown to alter channels behaviour through disruption of the actin cytoskeleton.  This study offers a new biological screen for compounds that act through the same mechanism of action.  The second compound, trigonelline, was shown to induce neuronal excitability in cultured DRG neurones by suppressing the outward voltage-activated potassium current.  The last chapter describes the cloning of patE gene as part of the efforts toward cloning of the gene cluster encoding the biosynthesis of the cyclic octapeptides patellamides, ascidiacyclamide and ulithiacyclamides from Prochloron didemni, the cyanobacterial symbiont of the tropical ascidian Lissoclinum patella.  The aim of the project is to get a sustainable supply of such biologically active compounds.
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Książki na temat "Marine drugs"

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Kim, Se-Kwon, red. Handbook of Anticancer Drugs from Marine Origin. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-07145-9.

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Anti-inflammatory drugs from plant and marine sources. Basel: Birkhauser, 1989.

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Shah, Muhammad Dawood, Julian Ransangan i Balu Alagar Venmathi Maran, red. Marine Biotechnology: Applications in Food, Drugs and Energy. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0624-6.

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1948-, Dierauf Leslie A., red. CRC handbook of marine mammal medicine: Health, disease, and rehabilitation. Boca Raton, Fla: CRC Press, 1990.

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Sex, drugs, and sea slime: The oceans' oddest creatures and why they matter. Chicago: University of Chicago Press, 2011.

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United States. Congress. House. Committee on Merchant Marine and Fisheries. Subcommittee on Coast Guard and Navigation. Airborne Drug Trafficking Deterrence Act: Hearing before the Subcommittee on Coast Guard and Navigation of the Committee on Merchant Marine and Fisheries, House of Representatives, One Hundred First Congress, second session, on H.R. 1343 ... H.R. 5301 ... October 2, 1990. Washington: U.S. G.P.O., 1991.

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United States. National Transportation Safety Board. Postaccident testing for alcohol and other drugs in the marine industry and the ramming of the Portland-South Portland (million dollar) Bridge at Portland, Maine, by the Liberian tankship Julie N on September 27, 1996. Washington, D.C. (490 L'Enfant Palza, S.W. Washington 20594): The Board, 1998.

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United States. Congress. House. Committee on Merchant Marine and Fisheries. Subcommittee on Coast Guard and Navigation. Coast Guard drug activities: Hearing before the Subcommittee on Coast Guard and Navigation of the Committee on Merchant Marine and Fisheries, House of Representatives, One Hundredth Congress, second session, on H.R. 4230, H.R. 4446, H.R. 4608, and 4658, bills to enforce drug laws, to curtail the flow of drugs into the United States, and promote a "drug free" America, June 15, 1988. Washington: U.S. G.P.O., 1988.

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United States. National Transportation Safety Board. Postaccident testing for alcohol and other drugs in the marine industry and the ramming of the Portland-South Portland (Million Dollar) Bridge at Portland, Maine, by the Liberian tankship Julie N on September 27, 1996: Special investigation report. Washington, D.C: National Transportation Safety Board, 1998.

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Rossoff, Irving S. Encyclopedia of clinical toxicology: A comprehensive guide and reference to the toxicology of prescription and OTC drugs, chemicals, herbals, plants, fungi, marine life, reptiles and insect venoms, food ingredients, clothing, and environmental toxins. Boca Raton: Parthenon Pub. Group, 2002.

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Części książek na temat "Marine drugs"

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Horta, André, Celso Alves, Susete Pinteus i Rui Pedrosa. "The marine origin of drugs". W Phycotoxins, 293–316. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118500354.ch13.

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Gomathi, T., Jayachandran Venkatesan i Sukumaran Anil. "Marine Biopolymers for Anticancer Drugs". W Industrial Applications of Marine Biopolymers, redaktor P. N. Sudha, 289–304. Boca Raton : CRC Press, [2017]: CRC Press, 2017. http://dx.doi.org/10.4324/9781315313535-11.

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Gomathi, T., Jayachandran Venkatesan i Sukumaran Anil. "Marine Biopolymers for Anticancer Drugs". W Industrial Applications of Marine Biopolymers, redaktor P. Sudha, 289–304. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2017. http://dx.doi.org/10.1201/9781315313535-15.

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Saeidnia, Soodabeh. "Marine-Derived Anticancer Compounds". W New Approaches to Natural Anticancer Drugs, 33–50. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14027-8_3.

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James, R. Arthur, S. Vignesh i K. Muthukumar. "Marine Drugs Development and Social Implication". W Coastal Environments: Focus on Asian Regions, 219–37. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-3002-3_15.

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Kobayashi, M. "Search for Biologically Active Substances from Marine Sponges". W Drugs from the Sea, 46–58. Basel: KARGER, 2000. http://dx.doi.org/10.1159/000062481.

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Quesada, Ana R., Beatriz Martínez-Poveda, Salvador Rodríguez-Nieto i Miguel Ángel Medina. "Marine Sponge Derived Antiangiogenic Compounds". W Handbook of Anticancer Drugs from Marine Origin, 29–58. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_3.

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Vansteelandt, Marieke, Catherine Roullier, Elodie Blanchet, Yann Guitton, Yves-François Pouchus, Nicolas Ruiz i Olivier Grovel. "Impact of Marine-DerivedPenicilliumSpecies in the Discovery of New Potential Antitumor Drugs". W Outstanding Marine Molecules, 45–84. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527681501.ch03.

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Kim, Se-Kwon, i Senthilkumar Kalimuthu. "Introduction to Anticancer Drugs from Marine Origin". W Handbook of Anticancer Drugs from Marine Origin, 1–13. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_1.

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Li, Yong-Xin, i Se-Kwon Kim. "Triterpenoids as Anticancer Drugs from Marine Sponges". W Handbook of Anticancer Drugs from Marine Origin, 15–27. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_2.

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Streszczenia konferencji na temat "Marine drugs"

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De La Calle, F. "Keynote Lecture “Marine Microbiome as Source of Innovative Drugs”". W GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1758907.

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Aravindan, Sheeja, Somasundaram T. Somasundaram, Mohan Natarajan, Terence S. Herman i Natarajan Aravindan. "Abstract 2074: Bioactive marine drugs target acquired oncogenic burden in resilient pancreatic cancer". W Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2074.

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Aravindan, Sheeja, Somasundaram T. Somasundaram, Mohan Natarajan, Terence S. Herman i Natarajan Aravindan. "Abstract 2074: Bioactive marine drugs target acquired oncogenic burden in resilient pancreatic cancer". W Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2074.

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Wewengkang, Defny S., Henki Rotinsulu, Deiske A. Sumilat, Hiroyuki Yamazaki, Syu-Ichi Kanno i Michio Namikoshi. "Evaluation on bioactivity of ascidian collected in North Sulawesi as seeds of marine-derived drugs". W THE 2ND INTERNATIONAL CONFERENCE ON NATURAL SCIENCES, MATHEMATICS, APPLICATIONS, RESEARCH, AND TECHNOLOGY (ICON-SMART 2021): Materials Science and Bioinformatics for Medical, Food, and Marine Industries. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0119405.

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Putri, Arlina Prima, Rizna Triana Dewi, Aniek Sri Handayani, Sri Harjanto i Mochamad Chalid. "Screening of proteins based on macro-algae from West Java coast in Indonesian marine as a potential anti-aging agent". W 2ND BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2017. Author(s), 2018. http://dx.doi.org/10.1063/1.5023966.

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Viallet, Pierre M., Emmanuelle Rocchi, Jean Vigo i Jean-Marie Salmon. "Multiwavelength videomicrofluorimetric method for a preliminary, fast, and inexpensive screening of the cytoxic properties of new drugs: application to some new marine peptides". W BiOS '99 International Biomedical Optics Symposium, redaktorzy Tuan Vo-Dinh, Warren S. Grundfest, David A. Benaron, Steven T. Charles, Richard D. Bucholz i Michael W. Vannier. SPIE, 1999. http://dx.doi.org/10.1117/12.351540.

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Torres, Veronica C., Sassan Hodge, Rachael Chacko, Joshua J. Levy, Louis J. Vaickus, Eunice Y. Chen, Matthew LeBoeuf i Kimberley S. Samkoe. "Whole-tissue margin evaluation for Mohs surgery using paired-agent imaging". W Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/omp.2023.om3e.4.

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Fluorescence paired-agent imaging combined with en face margin analysis can detect positive margins in low tumor-bearing (<1% tumor volume) whole tissue samples, as demonstrated in xenograft murine models.
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Rounds, Cody C., Jaron de Wit, Jasper Vonk, Floris Voskuil, Max J. H. Witjes i Kenneth M. Tichauer. "Margin status assessment using a ratio-metric angular domain fluorescent imaging approach in patients with head and neck squamous cell carcinoma". W Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/omp.2023.ow3e.3.

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Many head and neck squamous cell carcinoma surgical patients are left with residual tumor post excision surgery (inadequate margins). We present an imaging strategy capable of rapid margin status assessment to reduce overall surgical burden.
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Mann, Charlotte. "12 Opioids in palliative care: initiating drug treatment". W Marie Curie Palliative Care Research Conference. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/spcare-2019-mariecuriepalliativecare.12.

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Penny, David. "A Fallen Line of Marble Drums". W Proceedings of EVA London 2022. BCS Learning & Development, 2022. http://dx.doi.org/10.14236/ewic/eva2022.52.

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Raporty organizacyjne na temat "Marine drugs"

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Marchini, Geneviève Marthe Marie. Working paper PUEAA No. 16. The US exit from Afghanistan. Reverberation across Latin America. Universidad Nacional Autónoma de México, Programa Universitario de Estudios sobre Asia y África, 2023. http://dx.doi.org/10.22201/pueaa.001r.2023.

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In this paper, I aim to analyze which direct or indirect implications the US withdrawal from Afghanistan had for Latin America, especially in the economic sphere, an aspect less addressed. My point is that there were few direct economic effects, due to the lack of relevance of trade and investment links between Afghanistan and Latin American countries, but the consequences of the US exit reverberated through the global system and through its real and potential effects on topics of common interest. As peripheral and semi-peripheral countries, and despite the absence of international wars in the region, several Latin American countries share with Afghanistan aspects of an insertion in the global economy which includes illicit activities or activities at the margins of legality, like the production, transit and exports of drugs, or the privatization of war, or are affected by the struggles between the great powers, especially the United States and China. The paper is organized as follows: in a first section we briefly introduce the Afghan economy and show the weak links it maintains with Latin America. The second section discusses some immediate reactions to the US withdrawal in Latin America and examines one of its direct effects, related to the participation of Colombian military personnel and former soldiers in Afghanistan. The third section deals with the reverberations of the US exit on the “war on drugs,”, which involves several Latin American countries as well as Afghanistan, and the fourth section approaches the possible impacts on the international infrastructure initiatives in both regions. The last section concludes.
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