Gotowe bibliografie tematyczne / Mannose

Gotowa bibliografia na temat „Mannose”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 4 maja 2024

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Artykuły w czasopismach na temat "Mannose"

1

Sampaio, Maria-Manuel, Helena Santos i Winfried Boos. "Synthesis of GDP-Mannose and Mannosylglycerate from Labeled Mannose by Genetically Engineered Escherichia coli without Loss of Specific Isotopic Enrichment". Applied and Environmental Microbiology 69, nr 1 (styczeń 2003): 233–40. http://dx.doi.org/10.1128/aem.69.1.233-240.2003.

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ABSTRACT We report the construction of an Escherichia coli mutant that harbors two compatible plasmids and that is able to synthesize labeled 2-O-α-d-mannosyl-d-glycerate from externally added labeled mannose without the loss of specific isotopic enrichment. The strain carries a deletion in the manA gene, encoding phosphomannose isomerase. This deletion prevents the formation of fructose-6-phosphate from mannose-6-phosphate after the uptake of mannose from the medium by mannose-specific enzyme II of the phosphotransferase system (PtsM). The strain also has a deletion of the cps gene cluster that prevents the synthesis of colanic acid, a mannose-containing polymer. Plasmid-encoded phosphomannomutase (cpsG) and mannose-1-phosphate guanylyltransferase (cpsB) ensure the formation of GDP-mannose. A second plasmid harbors msg, a gene from Rhodothermus marinus that encodes mannosylglycerate synthase, which catalyzes the formation of 2-O-α-d-mannosyl-d-glycerate from GDP-mannose and endogenous glycerate. The rate-limiting step in 2-O-α-d-mannosyl-d-glycerate formation is the transfer of GDP-mannose to glycerate. 2-O-α-d-mannosyl-d-glycerate can be released from cells by treatment with cold-water shock. The final product is formed in a yield exceeding 50% the initial quantity of labeled mannose, including loss during preparation and paper chromatography.
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2

White, Catherine W., i Eric S. Jacobson. "Mannosyl transfer in Cryptococcus neoformans". Canadian Journal of Microbiology 39, nr 1 (1.01.1993): 129–33. http://dx.doi.org/10.1139/m93-019.

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A particulate enzyme preparation from Cryptococcus neoformans transferred the mannosyl residue from GDP-mannose:o an acceptor consisting of a commercial preparation of methyl 3-O-α-mannopyranosyl-α-mannopyranoside (confining 10% 2-O-α-mannopyranosyl-α-mannopyranoside). The configuration of the new bond was alpha by its susceptibility to α-mannosidase; the amount of product was dependent on the concentration of enzyme, of GDP-mannose, and of acceptor. The optimal temperature and pH were 37 °C and 7.0, respectively. Manganous ion was required for activity and acetyl coenzyme A was stimulatory. Studies suggested that dolichyl phosphate intermediates were not involved in this mannose transfer. The fact that none of the several acapsular mutants tested were deficient in this mannosyltransferase suggested that this enzyme was not involved in synthesis of backbone mannan linkages in capsular polysaccharide. NMR analysis of the methylmannotriose product showed only α(1 → 2) linkages between sugar moieties. This mannosyltransferase evidently extends α(1 → 2) mannan by adding another α(1 → 2)-linked mannosyl residue. Its activity is appropriate for a role in synthesis of "high mannose" oligosaccharide moieties of glycoproteins.Key words: virulence, capsular polysaccharide, acapsular mutants, dolichol pathway, oligomannans.
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Yoshida-Moriguchi, Takako, Tobias Willer, Mary E. Anderson, David Venzke, Tamieka Whyte, Francesco Muntoni, Hane Lee, Stanley F. Nelson, Liping Yu i Kevin P. Campbell. "SGK196 Is a Glycosylation-Specific O-Mannose Kinase Required for Dystroglycan Function". Science 341, nr 6148 (8.08.2013): 896–99. http://dx.doi.org/10.1126/science.1239951.

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Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine–β3-N-acetylglucosamine–β4-(phosphate-6-)mannose] is required for dystroglycan to bind laminin-G domain–containing extracellular proteins with high affinity in muscle and brain. However, the enzymes that produce this structure have not been fully elucidated. We found that glycosyltransferase-like domain–containing 2 (GTDC2) is a protein O-linked mannose β 1,4-N-acetylglucosaminyltransferase whose product could be extended by β 1,3-N-acetylgalactosaminyltransferase2 (B3GALNT2) to form the O-mannosyl trisaccharide. Furthermore, we identified SGK196 as an atypical kinase that phosphorylated the 6-position of O-mannose, specifically after the mannose had been modified by both GTDC2 and B3GALNT2. These findings suggest how mutations in GTDC2, B3GALNT2, and SGK196 disrupt dystroglycan receptor function and lead to congenital muscular dystrophy.
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Driessen, Nicole N., Esther J. M. Stoop, Roy Ummels, Sudagur S. Gurcha, Arun K. Mishra, Gérald Larrouy-Maumus, Jérôme Nigou i in. "Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan". Microbiology 156, nr 11 (1.11.2010): 3492–502. http://dx.doi.org/10.1099/mic.0.037507-0.

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Lipoarabinomannan (LAM) is a major glycolipid in the mycobacterial cell envelope. LAM consists of a mannosylphosphatidylinositol (MPI) anchor, a mannan core and a branched arabinan domain. The termini of the arabinan branches can become substituted with one to three α(1→2)-linked mannosyl residues, the mannose cap, producing ManLAM. ManLAM has been associated with a range of different immunomodulatory properties of Mycobacterium tuberculosis during infection of the host. In some of these effects, the presence of the mannose cap on ManLAM appears to be crucial for its activity. So far, in the biosynthesis of the mannose cap on ManLAM, two enzymes have been reported to be involved: a mannosyltransferase that adds the first mannosyl residue of the mannose caps to the arabinan domain of LAM, and another mannosyltransferase that elongates the mannose cap up to three mannosyl residues. Here, we report that a third gene is involved, MMAR_2380, which is the Mycobacterium marinum orthologue of Rv1565c. MMAR_2380 encodes a predicted transmembrane acyltransferase. In M. marinum ΔMMAR_2380, the LAM arabinan domain is still intact, but the mutant LAM lacks the mannose cap. Additional effects of mutation of MMAR_2380 on LAM were observed: a higher degree of branching of both the arabinan domain and the mannan core, and a decreased incorporation of [1,2-14C]acetate into the acyl chains in mutant LAM as compared with the wild-type form. This latter effect was also observed for related lipoglycans, i.e. lipomannan (LM) and phosphatidylinositol mannosides (PIMs). Furthermore, the mutant strain showed increased aggregation in liquid cultures as compared with the wild-type strain. All phenotypic traits of M. marinum ΔMMAR_2380, the deficiency in the mannose cap on LAM and changes at the cell surface, could be reversed by complementing the mutant strain with MMAR_2380. Strikingly, membrane preparations of the mutant strain still showed enzymic activity for the arabinan mannose-capping mannosyltransferase similar to that of the wild-type strain. Although the exact function of MMAR_2380 remains unknown, we show that the protein is essential for the presence of a mannose cap on LAM.
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Yoshida-komiya, Hiromi, Daulat Ram P. Tulsiani, Toshio Hirayama i Yoshihiko Araki. "Mannose-binding molecules of rat spermatozoa and sperm–egg interaction". Zygote 7, nr 4 (listopad 1999): 335–46. http://dx.doi.org/10.1017/s096719949900074x.

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We have previously reported the occurrence and partial characterisation of an α-D-mannosidase activity on plasma membranes of rat, mouse, hamster and human spermatozoa. A soluble isoform of the rat sperm surface mannosidase was purified and polyclonal antibody raised. Since several reports have suggested that mannosyl residues on the rat, mouse and human zona pellucida may be involved in sperm-zona binding, studies were undertaken to examine the receptor-like role of mannose-binding molecules on rat spermatozoa. Sprague-Dawley rats (25–30-days old) were superovulated and eggs collected from the oviduct were treated with 0.3% hyaluronidase to remove the cumulus cells. Spermatozoa, collected from the cauda epididymis were capacitated for 5 h at 37 °C in 5% CO2 in air. The sperm–zona binding assay was performed in the presence of increasing concentrations of several sugars as well as preimmune and immune (anti-mannosidase or anti-mannose binding protein) IgG. Data from these studies show that: (1) significantly fewer sperm bound per egg in the presence of competitive inhibitors of mannosidase; (2) among the sugars examined, D-mannose was the most potent inhibitor causing 70% reduction in the number of sperm bound per egg; (3) anti-mannosidase or anti-mannose binding protein (but not preimmune) IgG showed a dose-dependent reduction in the number of sperm bound per egg; (4) anti-mannosidase IgG (but not anti-mannose binding protein IgG) showed a dose-dependent inhibition of sperm surface mannosidase activity; (5) the competitive inhibitors of mannosidase or the immune IgG had no effect on sperm motility or the sperm acrosome reaction. These results suggest that mannose-binding molecule(s) such as α-D-mannosidase or mannose-binding protein on the spermatozoa may recognise mannosyl residues on zona pellucida, and play a receptor-like role in sperm-egg interaction in the rat.
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Cao, Huan, Heather J. Wassall, Megan A. Forrester, Lindsay S. Hall, Heather M. Wilson, Jenna Shepherd, Bhinal Patel i in. "Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria". Blood 132, Supplement 1 (29.11.2018): 3642. http://dx.doi.org/10.1182/blood-2018-99-117290.

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Abstract Heterozygosity for Hemoglobin (Hb) S, sickle cell trait (SCT), affects over 40 million people and confers resistance to severe infection by Plasmodium falciparum. Homozygosity for HbS, or compound heterozygosity with certain other alleles of Hb, affects over 4 million individuals and causes sickle cell disease (SCD). Hemolytic anaemia is a prominent feature of SCD and is mainly extravascular, mediated by hepatic and splenic macrophages. No ligands for this process have been identified. As many macrophage phagocytic receptors recognise carbohydrates, we surveyed surface glycan expression by sickle cells using a panel of 8 lectins and flow cytometry. Most glycans were similar to those of healthy red blood cells (RBC), except much higher expression of terminal mannose. We investigated the structural basis for these residues using glycomic mass spectroscopy, which showed them to be N-linked high (Man5-9GlcNAc2) mannoses, a surprising conclusion as these are usually intermediates in the formation of complex glycans and not displayed on cell surfaces. High resolution microscopy revealed the mannose residues to be carried in discrete microdomains on the surfaces of sickle cells. These structures were absent on the surfaces of healthy RBC, instead being present in the membrane skeleton under the cell surface. Lectin blots and immunoprecipitation showed the mannoses to co-migrate predominantly with spectrin. We showed these mannose-bearing structures were able to stimulate phagocytosis of RBC by using a peripheral blood derived macrophage uptake assay. Sickle RBC were taken up at high rates compared to healthy RBC and this could be inhibited by congeners of mannose. We identified the importance of a cognate ligand (CD206: the mannose receptor) using blocking antibodies and knockdown of CD206 expression using siRNA. The in vivo and pathogenic relevance of mannose exposure was investigated by taking advantage of the heterogeneity of hemolysis in SCD. RBC with SCD (n=94), SCT (n=57) and healthy individuals (n=54) were assayed for mannose exposure by flow cytometry. SCT and healthy RBC showed no mannose exposure but high levels were found on HbSS RBC (p<0.0001). Co-incident inheritance of HbSS with higher HbF values and alleles encoding alpha-thalassaemia resulted in lower surface mannose values. Overall, markers of hemolysis (RBC count, haemoglobin, reticulocyte count) correlated well with mannose exposure (Spearman correlation coefficients -0.68, -0.40, 0.37; p=0.0001, 0.0032, 0.0063 respectively). Plasma LDH is a marker of intravascular hemolysis and correlated with overall hemolysis within SCD (r=-0.25, p=0.016), but not mannose exposure (r=0.14, p=0.19). Thus mannose exposure correlated only with extravascular hemolysis. Identification of a ligand pair mediating rapid clearance of sickle cells raised the possibility that they also mediate enhanced clearance of SCT RBC infected by malarial parasites. Indeed, P. falciparum cultures induced mannose expression at the pigmented trophozoite and schizont stages in infected HbAA RBCs, at levels corresponding to mild hemolysis in SCD. Mannose expression in infected HbAS RBCs was even higher, with levels corresponding to severe hemolysis in SCD. Infection with P. falciparum and selection for HbS arose only recently in human evolution, raising the question of what the physiological triggers for this mechanism are. Infection with malarial parasites causes oxidative stress. We therefore subjected healthy RBC to copper sulphate, which resulted in surface mannose exposure as well as uptake by macrophages. Oxidized SCT RBC displayed more mannose than oxidized healthy RBC. Thus, we have identified a new cell surface 'eat me' signalling mechanism that allows inspecting macrophages to engage with the rigid membrane skeleton and phagocytose the mannose displaying cell. The mechanism is stimulated by HbS: when present in high concentrations, the mechanism is activated constitutively, resulting in sickle cell anaemia. Heterozygosity for HbS is insufficient by itself to trigger mannose exposure. However, the mechanism is primed so that oxidative stress associated with infection by P. falciparum causes greater mannose display, increased parasitized cell clearance and protection against severe malaria. These findings should allow the design of inhibitors of sickle cell haemolysis and inducers of protection against malaria. Disclosures Cao: University of Aberdeen: Patents & Royalties. Barker:University of Aberdeen: Patents & Royalties. Vickers:University of Aberdeen: Patents & Royalties; GSK: Equity Ownership.
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Paurević, Marija, Martina Šrajer Gajdošik i Rosana Ribić. "Mannose Ligands for Mannose Receptor Targeting". International Journal of Molecular Sciences 25, nr 3 (23.01.2024): 1370. http://dx.doi.org/10.3390/ijms25031370.

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The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides. Furthermore, multivalent mannose presentation on the various templates like peptides, proteins, polymers, micelles, and dendrimers was proven to be a valuable approach for the selective and efficient delivery of various therapeutically active agents to MR. This review provides a detailed account of the most relevant and recent aspects of the synthesis and application of mannosylated bioactive formulations for MR-mediated delivery in treatments of cancer and other infectious diseases. It further highlights recent findings related to the necessary structural features of the mannose-containing ligands for successful binding to the MR.
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Keiser, Tracy L., Abul K. Azad, Evelina Guirado, Robert Bonacci i Larry S. Schlesinger. "Comparative Transcriptional Study of the Putative Mannose Donor Biosynthesis Genes in Virulent Mycobacterium tuberculosis and Attenuated Mycobacterium bovis BCG Strains". Infection and Immunity 79, nr 11 (6.09.2011): 4668–73. http://dx.doi.org/10.1128/iai.05635-11.

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ABSTRACTMycobacterium tuberculosiscontains mannosylated cell wall components which are important in macrophage recognition and response. The building block for the mannosyl constituents of these components is GDP-mannose, which is synthesized through a series of enzymes involved in the mannose donor biosynthesis pathway. Nothing is known about the expression levels of the genes encoding these enzymes during the course of infection. To generate transcriptional profiles for the mannose donor biosynthesis genes from virulentM. tuberculosisand attenuatedMycobacterium bovisBCG, bacteria were grown in broth culture and within human macrophages. Our results with broth-grown bacteria show that there are differences in expression of the selected genes betweenM. tuberculosisand BCG, with increased expression ofmanCinM. tuberculosisandmanAin BCG during stationary-phase growth. Results forM. tuberculosisextracted from within macrophages show thatwhiB2is highly expressed andmanBandmanCare moderately expressed during infection.Rv3256c,Rv3258c, andppm1have high expression levels early and decreased expression as the infection progresses. Results with BCG show that, as inM. tuberculosis,whiB2is highly expressed throughout infection, whereas there is either low expression or little change in expression of the remaining genes studied. Overall, our results show that there is differential regulation of expression of several genes in the mannose donor biosynthesis pathway ofM. tuberculosisand BCG grown in broth and within macrophages, raising the possibility that the level of mannose donors may vary during the course of infection and thereby impact the biosynthesis of mannose-containing cell wall molecules.
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Peng, Xuan, Jun Sun, Chris Michiels, Dirk Iserentant i Hubert Verachtert. "Decrease in Cell Surface Galactose Residues ofSchizosaccharomyces pombe Enhances Its Coflocculation with Pediococcus damnosus". Applied and Environmental Microbiology 67, nr 8 (1.08.2001): 3413–17. http://dx.doi.org/10.1128/aem.67.8.3413-3417.2001.

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ABSTRACT Pediococcus damnosus can coflocculate withSaccharomyces cerevisiae and cause beer acidification that may or may not be desired. Similar coflocculations occur with other yeasts except for Schizosaccharomyces pombe which has galactose-rich cell walls. We compared coflocculation rates ofS. pombe wild-type species TP4-1D, having a mannose-to-galactose ratio (Man:Gal) of 5 to 6 in the cell wall, with its glycosylation mutants gms1-1 (Man:Gal = 5:1) and gms1Δ (Man:Gal = 1:0). These mutants coflocculated at a much higher level (30 to 45%) than that of the wild type (5%). Coflocculation of the mutants was inhibited by exogenous mannose but not by galactose. The S. cerevisiae mnn2 mutant, with a mannan content similar to that ofgms1Δ, also showed high coflocculation (35%) and was sensitive to mannose inhibition. Coflocculation of P. damnosus and gms1Δ (or mnn2) also could be inhibited by gms1Δ mannan (with unbranched α-1,6-linked mannose residues), concanavalin A (mannose and glucose specific), or NPA lectin (specific for α-1,6-linked mannosyl units). Protease treatment of the bacterial cells completely abolished coflocculation. From these results we conclude that mannose residues on the cell surface of S. pombe serve as receptors for a P. damnosuslectin but that these receptors are shielded by galactose residues in wild-type strains. Such interactions are important in the production of Belgian acid types of beers in which mixed cultures are used to improve flavor.
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Rip, Jack W., Joyce A. Williams, Dean C. Crick, Robert T. Rymerson i Kenneth K. Carroll. "Biosynthesis of glycosylated dolichol intermediates and asparagine-linked glycoproteins during the germination of soybean seed embryos". Biochemistry and Cell Biology 67, nr 7 (1.07.1989): 377–83. http://dx.doi.org/10.1139/o89-059.

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Soybean embryos germinated in the presence of [14C]glucose or [14C]mannose incorporated considerable radioactivity into chloroform–methanol (2:1) (CM) soluble and chloroform–methanol–water (10:10:3) (CMW) soluble and insoluble components. The amount of [14C]mannosyl dolichyl phosphate in CM extracts increased over the 24 h of germination, while their [14C]glucosyl dolichyl phosphate content increased up to about 7 h. Incorporation of glucose exceeded incorporation of mannose by about fivefold. The amount of mannose- and glucose-labeled oligosaccharyl dolichyl pyrophosphates in CMW-soluble extracts increased during germination and, based on Concanavalin A Sepharose binding, never exceeded 2% of the total label incorporated into CM-soluble and CMW-soluble, and CMW-insoluble components combined. Nearly equal amounts of [14C]glucose and [14C]mannose appear in oligosaccharyl dolichyl pyrophosphates in the CMW-soluble fraction. Although the CMW-insoluble component contained the largest single amount of radioactivity from either sugar, much of it was not in protein. The protein content of embryos increased during germination, as did the incorporation of [14C]mannose into concanavalin A binding and nonbinding proteins. Microsomes isolated from nongerminated and germinated embryos contained (i) a dolichol kinase, (ii) glycosyl transferases required for the formation of oligosaccharyl dolichyl pyrophosphates, and (iii) a phosphatase which acts on dolichyl phosphate. Kinase activity doubled in 20 h, while phosphatase activity remained at the relatively high initial level. Activity of all three glycosyl transferases was highest after 2 h of germination, but decreased back to zero-time levels by 20 h. The N-acetylglucosaminyl, mannosyl, and glucosyl transferase activities were initially present in a ratio of about 1:10:40 and this ratio did not change appreciably over the period of observation.Key words: dolichol, dolichyl phosphate, glycosyl transferases, oligosaccharyl dolichyl pyrophosphate, soybean seed embryo germination.
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Rozprawy doktorskie na temat "Mannose"

1

Pallanca, Jane Emma. "The chemo-enzymic synthesis of GDP-mannose and GDP-mannose analogues". Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294003.

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JAZIRI, NOUREDDINE. "Analogues de gdp-mannose : inhibiteurs potentiels de la gdp-mannose deshydrogenase". Paris 6, 1992. http://www.theses.fr/1992PA066661.

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Cette these est consacree a la synthese de molecules analogues du gdp-mannose, substrat d'une enzyme specifique de la biosynthese des alginates chez les souches mucoides de pseudomonas aeruginosa: la gdp-mannose deshydrogenase. Dans la premiere partie de ce travail, nous avons choisi une strategie qui consiste en une protection convenable de la guanosine en vue de brancher en position 5 une chaine qui reliera le nucleoside a un derive du mannose. La seconde partie est relative a l'etude de la chimie du ribose au moyen de reactions classiques de protection en positions 1, 2 et 3 et le branchement de differentes chaines en position3 15. Dans la troisieme partie, ont ete mises au point differentes methodes d'activation de la position anomere du mannose ainsi que les conditions de condensation avec les differentes chaines en 5 du ribose. Les methodes de couplage de vorbruggen ont ete utilisees pour la condensation de la guanine et d'autres bases pyrimidiques en position 1 du ribose. La quatrieme partie relate l'ensemble des proprietes biologiques des produits obtenus
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Tailford, Louise Elizabeth. "Catalytic recognition of mannose". Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437254.

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Mba, Mintsa Léa. "Synthèse et évaluation angiogénique d'analogues du M6P". Thesis, Montpellier, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCM0028.

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L’angiogenèse, est le garant de l’intégrité vasculaire, grâce à la formation de nouveaux vaisseaux sanguins à partir des préexistants. Cette néovascularisation est régulée par des facteurs angiogéniques. Plusieurs stimuli participent au déséquilibre de la balance angiogénique, une vascularisation anormale en résulte. L’intérêt des thérapies actuelles est de restaurer une vascularisation normale, par ciblage des facteurs impliqués dans le processus angiogénique. Il fut démontré que le RM6P-CI est partie prenante dans ce mécanisme. Il a la particularité d’interagir avec plusieurs ligands, dont le M6P et ses dérivées.Il est question de savoir si le M6A, un dérivé isostère du M6P, se lie au RM6P-CI. Pour cela, le test CAM légèrement modifié, a été réapproprié pour confirmer premièrement l’activité pro-angiogénique du M6A. Deuxièmement la technique de cytométrie en flux est utilisée pour mettre en évidence l’interaction entre le M6A et le RM6P-CI
Angiogenesis is the protector of vascular integrity, through the formation of new blood vessels from pre-existing vessels. The angiogenesis is regulated by the angiogenic factors. Several stimuli are involved in the angiogenic balance’s destabilization, which produces an unusual vascularization. The interest of conventional and targeted therapies is to restore a normal vascularization, by targeting all the factors which are involved in the angiogenic process. It has been demonstrated that the CI-M6PR is involved in this mechanism. This receptor has the distinction of having more binding sites, so a variety of ligands, including the M6P and its analogs. During this study we want to know if the M6P, isostere analog of M6P, interacts with the CI-M6PR. For this, we reappropriated the assay CAM, slightly modified, to confirm at first the pro-angiogenic activity of M6A. In a second step we will use the flow cytometry technique to highlight the interaction between the M6A and CI- M6PR
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Castilla, López Javier. "Carbohydrate manipulations towards high-mannose oligosaccharides". Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/87113.

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L’objectiu d’estudi de la tesi és el desenvolupament de nous mètodes sintètics per a la l’obtenció d’oligosacàrids i tio-anàlegs mitjançant processos polimèrics d’obertura d’anell. Aquestes estructures es poden trobar en una gran varietat de productes naturals on formen part de substàncies biològicament actives. D’aquesta manera, s’han desenvolupen rutes sintètiques per l’obtenció de carbohidrats epóxidats, episulfurats, carbonatats i tiocarbonatats. Els monòmers sintetitzats han estat sotmesos a diferents reaccions d’oligomerització. Curiosament, la cerca de nous mètodes de síntesi d’epitio-carbohidrats va donar lloc al descobriment de sucres 1,3-oxazolin-2-tioderivats. Aquests nous compostos han esdevingut inhibidors altament específics de β-glucosidases amb un gran potencial contra la malaltia de Gauche. Els diferents estudis d’inhibició es troben recollits en la memòria.
The final goal of this thesis is the development of strategic methods fro the synthesis of well-defined 1,2-linked oligosaccharides and S-linked thio-analogues through different polymerization techniques. These structures form a complex group of biomolecules with an unsurpassed structural diversity, performing a variety of biological functions. In this context, the present work aimed to develop new procedures in carbohydrate chemistry, focusing in the oligomerization reactions. Thus, efficient syntheses have been studied for accessing the suitable carbohydrate based monomers (including epoxides, episulfides, carbonates and tiocarbonates). Unexpectedly, the synthesis of epithiocarbohydrates afforded carbohydrate-derived 1,3-oxazolidine-2-thiones. These compounds have proved to be quite attractive as new enzyme inhibitors for Gaucher disease. All enzyme inhibition studies can be found in the manuscript.
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6

Gazi, Umut. "The mannose receptor in macrophage biology". Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11587/.

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The Mannose receptor (MR) is a type I membrane molecule involved in both haemostasis and pathogen recognition. Its extracellular domains have broad ligand specificities: the cysteine-rich (CR) domain is involved in sulphated sugar binding, the C-type lectin-like domains (CTLDs) are responsible for the detection of sugars terminated in mannose, fucose or N-acetylglucosamine, and the fibronectin-type II (FNII) domain mediates collagen binding. Its recently discovered collagen binding ability raised the question of MR facilitating cellular adhesion which would then influence its function as an endocytic receptor in collagen-rich mammalian tissues. For this purpose, the level of MR-mediated endocytosis, and MR expression was analyzed by using bone-marrow-derived macrophages (BM-MΦ) plated on extracellular matrix (ECM) proteins including fibronectin (not a MR ligand), collagen type I or IV (MR-ligands). The results showed no difference in the level of MR-mediated endocytosis and MR expression at both mRNA and protein levels upon MΦ adhesion to collagen. This suggests that MR interaction with collagen may simply be crucial for tissue remodelling and wound healing, rather than adhesion. MR is also expressed in a soluble form (sMR) which is comprised of the extracellular region of intact cell-associated MR (cMR). Even though its precise role is not yet clear, enhanced sMR production was previously shown to help Pneumocystis carinii to evade M phagocytosis by forming a protective coat around the organism. In this work, the mechanism responsible for the fungi-induced MR-shedding was studied by treating MΦ with fungal particles in the presence and the absence of a wide-range of inhibitors. After treatment in serum-free conditions, the cell lysate and cell culture supernatants were analyzed by western blot, for cMR and sMR expression respectively. It was shown that fungi species other than P. carinii can also trigger sMR production, and that this effect mainly takes place through -glucan recognition. Using bio-active particulate -glucan, it was also demonstrated that MR cleavage upon -glucan recognition requires dectin-1-mediated signalling involving Syk, PI3K, and, partially, Raf-1 and that is mediated by a non-secreted metalloproteinase. Dectin-1-mediated MR-shedding may partially explain the contradictive data on the involvement of cMR in the development of immunity against fungi, as well as other pathogens recognised by dectin-1. The ability of pathogens to evade or activate the immune response may depend on the balance between sMR and cMR expression levels.
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Williams, Paula Mary. "Studies towards the chemo-enzymatic synthesis of carba-GDP-mannose; A mannosyl transferase donor substrate analogue". Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534664.

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Vidil, Carole. "Synthèses et évaluations biologiques de phosphonates analogues du mannose 6-phosphate, substrats potentiels du récepteur mannose 6-phosphate". Montpellier 2, 1997. http://www.theses.fr/1997MON20247.

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Le recepteur mannose 6-phosphate (rm6p) transporte les enzymes lysosomales via la reconnaissance de l'<<<>etiquette<>>> mannose 6-phosphate. Parmi ces enzymes, la cathepsine d (cath d) est impliquee dans le developpement metastatique du cancer du sein. Il a ete montre anterieurement, que la neoglycoproteine bsa(m6p)#3#0 inhibait fortement, in vitro, la migration des cellules metastatiques par blocage des rm6p. Mais la liaison p-o des phosphates est facilement hydrolysable par les phosphatases presentes dans les cellules. Afin de pallier a ce probleme nous avons synthetise deux phosphonates analogues du m6p, l'un isostere qui presente une tres bonne affinite vis-a-vis des rm6p, l'autre non isostere qui ne presente aucune affinite vis-a-vis de ces memes recepteurs. Nous avons par consequent prepare un phosphonate analogue isostere du m6p, fonctionnalise en position anomerique. Par l'intermediaire de ce bras espaceur, le residu m6pn a ete couple a la bsa. Le bioconjugue ainsi forme a vu son activite biologique testee vis-a-vis de la migration et de la proliferation cellulaire. Le meme residu m6pn a ete couple a un derive du cholesterol pour former le neoglycolipide m6pn/csa. Ce dernier a permis d'etudier les phenomenes de reconnaissance cellulaire. L'association <<<>vesicules geantes-m6pn/csa<>>> permet donc un ciblage vers des cellules exprimant le rm6p et pourrait donc constituer un outil puissant d'investigations dans le domaine de la therapie genique (ciblage de plasmide).
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Napper, Catherine E. "Functional analysis of the macrophage mannose receptor". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249560.

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Chavele, Konstantia-Marie. "The role of Mannose receptor in glomerul". Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508459.

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Książki na temat "Mannose"

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Messias-Reason, Iara De. Mannose-binding lectin in the innate immune system. Hauppauge, N.Y: Nova Science, 2009.

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W, Boldt Angelica B., red. Mannose-binding lectin in the innate immune system. Hauppauge, N.Y: Nova Science, 2009.

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Lawlor, Margaret Ann. The role of the insulin-like growth factor-II/mannose-6-phosphate receptor in embryonic development. Dublin: University College Dublin, 1998.

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Stoute, Beverly Jean. Effect of low temperature on the trafficking of 215 kD mannose-6-phosphate/IGF-II receptors in rat clone 9 hepatocytes. [New Haven: s.n.], 1990.

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Bjarnason, Bjarni. Mannorð. [Akranes]: Uppheimar, 2011.

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Smith, Adrian. Mick Mannock. London: Palgrave Macmillan UK, 2001. http://dx.doi.org/10.1057/9780230286627.

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Fiorella Mannoia. Foggia: Bastogi, 2000.

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Andrews, Elizabeth B., i Nicholas Moore, red. Mann's Pharmacovigilance. Oxford, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118820186.

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Yi, Hŏn-yŏng. Kyŏngwa mannok. Kyŏnggi-do Kwach'ŏn-si: Kuksa P'yŏnch'an Wiwŏnhoe, 2008.

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Sarang hanŭn saram mot mannasŏ koeropko miwŏ hanŭn saram mannasŏ koeropnani. Sŏul: Ŏnŏ Munhwa, 1993.

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Części książek na temat "Mannose"

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Yang, Bob, i Steve Foley. "d-Mannose". W Female Urinary Tract Infections in Clinical Practice, 49–51. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27909-7_7.

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Sharma, Vandana, i Hudson Freeze. "Mannose Phosphate Isomerase (MPI)". W Handbook of Glycosyltransferases and Related Genes, 1581–89. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54240-7_20.

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Olson, Linda J., i Nancy M. Dahms. "Mannose 6-Phosphate Receptors". W Glycoscience: Biology and Medicine, 1–10. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54836-2_62-1.

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Olson, Linda J., i Nancy M. Dahms. "Mannose 6-Phosphate Receptors". W Glycoscience: Biology and Medicine, 1037–47. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54841-6_62.

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Schomburg, Dietmar, i Dörte Stephan. "Dolichyl-phosphate-mannose phosphodiesterase". W Enzyme Handbook 15, 177–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58948-5_41.

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Gewies, Andreas, Jürgen Ruland, Alexey Kotlyarov, Matthias Gaestel, Shiri Procaccia, Rony Seger, Shin Yasuda i in. "Macrophage Mannose Receptor 2". W Encyclopedia of Signaling Molecules, 1033. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100736.

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Schomburg, Dietmar, i Dörte Stephan. "Mannose-1-phosphate guanylyltransferase". W Enzyme Handbook, 541–45. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59025-2_98.

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Schomburg, Dietmar, i Dörte Stephan. "Mannose-6-phosphate 6-reductase". W Enzyme Handbook 10, 264–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-57756-7_72.

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Schomburg, Dietmar, i Dörte Stephan. "Dolichyl-phosphate-mannose-protein mannosyltransferase". W Enzyme Handbook 12, 531–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_109.

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Ezekowitz, R. A. B. "The mannose receptor and phagocytosis". W Mononuclear Phagocytes, 208–13. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-015-8070-0_28.

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Streszczenia konferencji na temat "Mannose"

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Li, Yu, Dong-jun Kong, Fu-ping Lu, Tao Niu, Hong-hong Jia i Ke He. "Synthesis of GDP-Mannose in Recombinant Escherichia coli". W 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5517296.

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Mahdi, Lamyaa Salih, Adnan Ibrahim Mohammed i Majid Jary Mohammed. "Convenient synthesis of dipropargyl ether derivative of D-mannose". W INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS ICNAAM 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0027403.

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Scheefers, H., A. Kobus i R. Geyer. "CARBOHYDRATE COMPOSITION AND LECTIN BINDING AFFINITIES OF HUMAN PLACENTAL TISSUE FACTOR". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643737.

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Tissue factor (TF) is a widely distibuted membrane glycoprotein and the most potent trigger of bloodcoagulation. It serves as an essential cofactor for the activation of Factor IX and X by Factor Vll/VIIa.TF is a lipoprotein composed of a phospholipid portion and a glycosylated apoprotein (apo-TF). The procoagulant activity of bovine brain TF is inhibited bythe lectin Con A indicating that the carbohydrates of TF might play a functional role in its interactionwith Factor Vll/VIIa.In the present study apo-TF was purified from human placenta by repeated SDS-PAGE to a purity of 95%. The carbohydrates of apo-TF wereanalyzed by capillary gas- liquid-chromatography andmass-fragmentography. This analysis revealed that apo-TF contains about 16% (w/w) carbohydrate consistingof 50.4 mole% N-acetylglucosamine, 22.2 mole% mannose, 21.0 mole% galactose, 3.2 mole% fucose and 3.2 mole% N-acetylgalactosamine. Further information on the structure of the carbohydrate moieties of the apoTF was achieved by determining the binding affinities of the apo-TF to ten different lectins. For this purpose a semiquantitative spot lectino sorbent assaywas developed. This assay is based on the detection of peroxidase-labeled lectins after being bound to the carbohydrate moieties of apo-TF adsorbed onto a nitrocellulose membrane. Human placental apo-TF showed the strongest affinity to wheat germ agglutinin which specifically binds to N-acetylglucosamine and sialic acid residues.In contrast to bovine brain apo-TF, human placental apo-TF only weakly interacted with Con A, which is known to recognize mannosyl residues in mannose-rich, hybrid- and biantennary glycans,but not in tri- or tetraantennary oligosaccharides of the complex type. From the carbohydrate constituent analysis and from the lectin binding studies it can be concluded that human placental apo-TF carriesabout four N-linked higher branched oligosaccharide chains.
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Khare, H., V. Ratnaparkhi, V. K. Jayraman, Swapan Paruya, Samarjit Kar i Suchismita Roy. "Prediction of Mannose Binding Sites in Proteins employing SVM Classification". W INTERNATIONAL CONFERENCE ON MODELING, OPTIMIZATION, AND COMPUTING (ICMOS 20110). AIP, 2010. http://dx.doi.org/10.1063/1.3516409.

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Bischoff, S., S. Hackenberg, R. Hagen i A. Scherzad. "Antitumorwirkung von D-Mannose auf Kopf-Hals-Plattenepithelkarzinome durch Autophagie-Induktion". W Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711575.

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Yamashita, Masahiro, Miyuki Niisato, Yasushi Kawasaki i Makoto Maemondo. "Protective roles of mannose receptor in an experimental pulmonary fibrosis model". W ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa1000.

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Thomas, Wendy E., Evgeni V. Sokurenko i Viola Vogel. "How Bacteria Bind More Strongly Under Mechanical Force: The Catch-Bond FimH". W ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43680.

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We study a protein that responds to mechanical force in most striking manner. We demonstrate that Escherichia coli bacteria need shear stress to bind to certain tissues and model surfaces; they bind strongest precisely when the body tries to wash them off. We have determined that the protein responsible for this behavior is FimH, a ubiquitous adhesion protein in intestinal bacteria that mediates adhesion to host cells via the carbohydrate mannose. Although mechanical force noramlly decreases bond lifetimes, we have shown that the bond betweeen FimH and simple mono-mannose receptors is s “catch-bond” that lasts longer under shear stress. In contrast, structural variations in either FimH or the receptor cause a stronger mode of adhesion in static conditions with little or no activation under force. We derive a structural for how mechanical force switches FimH to a strong binding mode by using steered molecular dynamics simulations, and validate the predictions with subsequent site-directed mutagenesis. The physiological consequences as well as the engineering principles suggested by the structural model will be discussed.
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Fujimura, Tetsuo, Ikumi Sugiyama, Kazunori Murai, Yoji Ishida, Naoto Oku i Yasuyuki Sadzuka. "Abstract 2901: Development of mannose-polyethyleneglycol-modified liposomes for idiopathic thrombocytopenic purpura". W Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2901.

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Gregersen, S., B. Fevang, J. Kongerud, P. Aukrust, SS Froland i B. Johansen. "Serum Mannose Binding Lectin, IgA and Pulmonary Function in Common Variable Immunodeficiency." W American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6285.

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Malla, Bijaya, Jyotshna Mandal, Luigi Costa, Rudi Steffensen, Adrian Egli, Tobias Welte, Antoni Torres i in. "Mannose binding lectin -HYPDallele is associated with frequent exacerbation in COPD patients". W Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.oa2921.

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Raporty organizacyjne na temat "Mannose"

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Miyagawa, Atsushi. Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli. Peeref, czerwiec 2023. http://dx.doi.org/10.54985/peeref.2306p3746137.

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Spiegel, Yitzhak, Michael McClure, Itzhak Kahane i B. M. Zuckerman. Characterization of the Phytophagous Nematode Surface Coat to Provide New Strategies for Biocontrol. United States Department of Agriculture, listopad 1995. http://dx.doi.org/10.32747/1995.7613015.bard.

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Chemical composition and biological role of the surface coat (SC) of the root-knot nematodes, Meloidogyne spp. are described. SC proteins of M. incognita race 3 infective juveniles (J2) were characterized by electrophoresis and western blotting of extracts from radioiodine and biotin-labelled nematodes. J2 labelled with radioiodine and biotin released 125I and biotin-labelled molecules into water after 20 hours incubation, indicating that SC proteins may be loosely attached to the nematode. Antiserum to the principal protein reacted with the surface of live J2 and with surface proteins previously separated by electrophoresis. Human red blood cells (HRBC) adhered to J2 of several tylenchid nematodes over the entire nematode body. HRBC adhered also to nylon fibers coated with SC extracted from M. javanica J2; binding was Ca++/Mg++ dependent, and decreased when the nylon fibers were coated with bovine serum albumin, or pre-incubated with fucose and mannose. These experiments support a working hypothesis that RBC adhesion involves carbohydrate moieties of HRBC and carbohydrate-recognition domain(s) (CRD) distributed on the nematode surface. To our knowledge, this is the first report of a surface CRD i the phylum Nematoda. Gold-conjugated lectins and neoglycoproteins combined with silver enhancement have been used for the detection of carbohydrates and CRD, respectively, on the SC of M. javanica J2. Biotin reagents were used to trace surface proteins, specifically, on live J2. The labile and transitory nature of the SC was demonstrated by the dynamics of HRBC adherence to detergent-treated J2, J2 at different ages or fresh-hatched J2 held at various temperatures. SC recovery was demonstrated also by a SDS-PAGE profile. Monoclonal antibodies developed to a cuticular protein of M. incognita J2 gave a slight, but significant reduction in attachment of Pasteuria penetrans spores. Spore attachment as affected by several enzymes was inconsistent: alcian blue, which specifically blocks sulfyl groups, had no afffect on spore attachment. Treatment with cationized ferritin alone or catonized ferritin following monoclonal antibody caused significant decreases in spore attachment. Those results suggest a role in attachment by negatively charged groups.
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Morgan, Thomas. Homoeroticism and Thomas Mann's Death in Venice. Portland State University Library, styczeń 2000. http://dx.doi.org/10.15760/etd.6681.

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Survilla, Thomas. The isolation of an individual : Thomas Mann's Tonio Kröger. Portland State University Library, styczeń 2000. http://dx.doi.org/10.15760/etd.2898.

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Flood discharges and hydraulics near the mouths of Wolf Creek, Craig Branch, Manns Creek, Dunloup Creek, and Mill Creek in the New River Gorge National River, West Virginia. US Geological Survey, 1994. http://dx.doi.org/10.3133/wri934133.

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