Rozprawy doktorskie na temat „Manipulation de laboratoire”
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Marbach, Nathalie. "Risques lies a la manipulation du virus de la vaccine dans les laboratoires". Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR1M099.
Pełny tekst źródłaRabaud, David. "Manipulation et interaction de micro-bulles sous champ acoustique". Phd thesis, Grenoble, 2010. http://tel.archives-ouvertes.fr/tel-00536932.
Pełny tekst źródłaGourbal, Benjamin. "Relations interspécifiques dans le modèle souris BALB/c/Taenia crassiceps. Le "comment" avant le "pourquoi" de la manipulation". Montpellier 2, 2002. http://www.theses.fr/2002MON20078.
Pełny tekst źródłaBrun, Mathieu. "Électrodes nanocomposites pour applications en microfluidique". Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00744588.
Pełny tekst źródłaRiaud, Antoine Jean-Pierre René. "Etude des potentialités offertes par la synthèse de champs d'ondes acoustiques de surface pour l'actionnement de liquides et la manipulation sans contact". Thesis, Ecole centrale de Lille, 2016. http://www.theses.fr/2016ECLI0010/document.
Pełny tekst źródłaWhen surface acoustic waves radiate in nearby fluids, they trigger two nonlinear effects: acoustic radiation pressure and acoustic streaming. These two effects find numerous applications for digital microfluidics, contactless manipulation and biological cell sorting. Nonetheless, these systems face two limitations. On the one hand, each application requires a specific acoustic wave: there is no multifunction device so far. On the other hand, search for functionalities offered by simple surface acoustic waves (plane and focused waves) has failed to provide a selective tweezers able to manipulate individual particles or cells independently of their neighbors. In the first part of this thesis, we develop two methods to synthesize complex surface acoustic wave fields. The first one employs an array of 32 interdigitated transducers controlled by the inverse filter to generate arbitrary fields on demand. The second method solves an inverse problem to design a holographic transducer to generate a predefined field. In the second part of the thesis, we use the inverse filter to (i) implement a multifunction lab on a chip and (ii) investigate the potentialities of a special type of surface acoustic waves called swirling surface waves. These waves enable a selective and contactless manipulation of microscopic objects. We conclude the thesis by integrating a holographic acoustical vortex transducer on a microscope in order to selectively manipulate biological cells without contact
Ehlert, Jannik F. "Optoelectronic characterization and modeling of external cavity semiconductor diode lasers for metrological applications". Electronic Thesis or Diss., Institut polytechnique de Paris, 2022. http://www.theses.fr/2022IPPAT013.
Pełny tekst źródłaQuantum dots have been proven to be a high performing technology for solitary laser diodes. By varying dot sizes, shapes, and by using an antireflection output facet, gain chips can be designed to emit over a large wavelength range in tunable lasers. This PhD thesis work deals with both the simulation of an external cavity laser and the experimental characterization of a quantum dot gain chip-based tunable laser. A rate equation model has been derived. The numerical simulation investigates dynamical properties like turn-on delay, gain clamping and damping rate. This work shows the integration of a quantum dot gain chip in a Littman-Metcalf laser setup. Also, a new method has been developed to spectrally resolve the gain chip’s spontaneous emission in the far-field. A wavelength referencing mechanism utilizing a Fabry- Perot etalon is laid out in detail. Finally, a prototype of a newly developed high power tunable laser without servo control has been tested for long term mode-hop free operation
Moral, Zamora Beatriz del. "Bioimpedance & dielectrophoresis instrumentation equipments for living cells manipulation and monitoring". Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/395178.
Pełny tekst źródłaEl objetivo de esta tesis es el diseño de una instrumentación capaz de manipular y caracterizar células, a fin de realizar análisis más exhaustivos de elementos biológicos y acelerar procesos de detección de patógenos para aplicaciones de diagnóstico o de control de calidad de alimentos. El dispositivo se centra en dos tipos de técnicas eléctricas para la manipulación y detección de células: La dielectroforesis (DEP) y la medición de la bioimpedancia. La DEP permite manipular material biológico por medio de campos eléctricos, aprovechando las propiedades eléctricas de la célula y el medio en que se encuentra. La manipulación es por tanto ajustable, mediante el control de estas propiedades, así como a través de la geometría de los electrodos usados, la frecuencia y el módulo de la tensión aplicada. Por otro lado, la IS permite caracterizar material biológico mediante su comportamiento eléctrico en frecuencia. La medida se realiza a través de la aplicación de una corriente alterna controlada y la monitorización del efecto sobre el tejido mediante potencial eléctrico. Los dispositivos de IS son fácilmente integrables con técnicas dielectroforéticas de manipulación, fusionando manipulación con detección. En esta tesis, la combinación de estas técnicas permite la concentración de pequeños patógenos en grandes volúmenes de muestras y su posterior detección. Para ello, se crean diversos módulos de instrumentación electrónica. Algunos, están dedicados a generar señales alternas desfasadas a frecuencias óptimas para la manipulación de patógenos (módulo DEP). Otros, combinan módulos de generación, lectura y tratamiento digital, para la monitorización del comportamiento eléctrico de células (IS). Los módulos diseñados son validados en un entorno real controlado para concentrar y detectar la bacteria Escherichia Coli en grandes volúmenes de agua. Como resultado, se obtiene una electrónica modular válida, autónoma, portátil y de bajo coste, capaz de disminuir tiempos de preparación y detección de muestras en laboratorio.
Burn, C. C. "Effects of husbandry manipulations and the laboratory environment on rat health and welfare". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433382.
Pełny tekst źródłaNg, Koon-kiu, i 吳官橋. "Using zebrafish as a model organism for the study of embryonic hematopoiesis based on chemical screening and genetic manipulation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B5071322X.
Pełny tekst źródłapublished_or_final_version
Medicine
Master
Master of Research in Medicine
Ceballo, Charpentier Sebastian Arturo. "Causal manipulations of auditory perception and learning strategies in the mouse auditory cortex". Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS058.
Pełny tekst źródłaThrough our senses, the brain receives an enormous amount of information. This information needs to be filtered in order to extract the most salient features to guide our behavior. How the brain actually generates different percepts and drives behavior, remain the two major questions in modern neuroscience. To answer these questions, novel neural engineering approaches are now employed to map, model and finally generate, artificial sensory perception with its learned or innate associated behavioral outcome. In this work, using a Go/noGo discrimination task combined with optogenetics to silence auditory cortex during ongoing behavior in mice, we have established the dispensable role of auditory cortex for simple frequency discriminations, but also its necessary role to solve a more challenging task. By the combination of different mapping techniques and light-sculpted optogenetics to activate precisely defined tonotopic fields in auditory cortex, we could elucidate the strategy that mice use to solve this hard task, revealing a delayed frequency discrimination mechanism. In parallel, observations about learning speed and sound-triggered activity in auditory cortex, led us to study their interactions and causally test the role of cortical recruitment in associative learning, revealing it as a possible neurophysiological correlate of saliency
Antonello, Andrea. "Design of a robotic arm for laboratory simulations of spacecraft proximity navigation and docking". Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426208.
Pełny tekst źródłaIl crescente numero di oggetti umani nello spazio ha posto le basi per una nuova classe di missioni orbitali per l'assistenza e la manutenzione. L'obiettivo principale di questa tesi è lo sviluppo, la costruzione e la verifica sperimentale di un manipolatore robotico per la simulazione di manovre orbitali, con particolare attenzione alla rimozione di detriti (ADR) e la manutenzione in orbita (OOS). Allo stato dell'arte, sono poche le modalità utilizzate per la riproduzione della microgravità in un ambiente non-orbitale: fra le tecniche principali, vale la pena ricordare voli parabolici, simulazioni in piscina e simulatori robotici. I voli parabolici consentono di riprodurre le condizioni orbitali abbastanza fedelmente, ma le condizioni di simulazione sono pesantemente vincolanti. Le simulazioni in piscina, d'altra parte, hanno meno costrizioni in termini di costo, ma la resistenza indotta dall'acqua influisce negativamente sulla qualità della microgravità simulata. Gli impianti robotizzati, infine, permettono di riprodurre indirettamente (cioè attraverso un adeguato sistema di controllo) la fisica della microgravità. Lo stato dell'arte sulle simulazioni robotiche 3D è oggi limitato a robot industriali, caratterizzati da notevoli costi sia in termini di hardware che di manutenzione. Questo progetto propone un'alternativa a queste strutture: attraverso algoritmi dedicati, il sistema è in grado di calcolare in tempo reale le conseguenze dei contatti tramite le opportune modifiche alla traiettoria, che vengono poi fornite al sistema di controllo "hardware in the loop" (HIL). Inoltre, il software può essere comandato per eseguire manovre attive e di "relocation": di conseguenza, il manipolatore può essere utilizzato come test-bed non solo per operazioni di manutenzione orbitale, ma anche per sistemi di controllo di assetto, fornendo una fedele simulazione in tempo reale del rispettivo comportamento in assenza di gravità. La tesi descrive la progettazione meccanica dettagliata della struttura, corroborata dalla rispettiva modellazione strutturale, e dalla verifica agli elementi finiti delle prestazioni statiche e vibrazionali. Viene successivamente presentata una strategia per la simulazione di contatti tramite il matching tra le impedenze e un controllore dedicato definisce l'insieme delle proprietà inerziali simulabili tramite la struttura. Concentrandosi sugli scenari di simulazione, viene poi presentato un innovativo approccio SLAM (simultaneous localization and mapping) che utilizza metodi stocastici per il design di traiettorie di ispezione e riconoscimento markers applicato ad un task di rendez-vous 3D. Infine, con l'obiettivo di fornire una sensor-suite capace di stimare in real-time l'assetto dell'end-effector, viene descritto un innovativo sensore di Sole miniaturizzato. Ne vengono discusse la progettazione e la fabbricazione, corroborate dalle necessarie verifiche sperimentali.
Fong, Terrence W. "Design and testing of a Stewart Platform Augmented Manipulator for space applications". Thesis, Massachusetts Institute of Technology, 1990. http://hdl.handle.net/1721.1/43002.
Pełny tekst źródłaNevřiva, Václav. "Inteligentní manipulace s laboratorními objekty pomocí robotu ABB YuMi". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-442858.
Pełny tekst źródłaChini, Jacquelyn J. "Comparing the scaffolding provided by physical and virtual manipulative for students' understanding of simple machines". Diss., Kansas State University, 2010. http://hdl.handle.net/2097/6391.
Pełny tekst źródłaDepartment of Physics
Nobel S. Rebello
Conventional wisdom has long advised that students’ learning is best supported by interaction with physical manipulative. Thus, in the physics laboratory, students typically spend their time conducting experiments with physical equipment. However, computer simulations offer a tempting alternative to traditional physical experiments. In a virtual experiment, using a computer simulation, students can gather data quickly, and measurement errors and frictional effects can be explicitly controlled. This research investigates the relative support for students’ learning offered by physical and virtual experimentation in the context of simple machines. Specifically, I have investigated students’ learning as supported by experimentation with physical and virtual manipulative from three different angles-- what do students learn, how do students learn, and what do students think about their learning. The results indicate that the virtual manipulative better supported students’ understanding of work and potential energy than the physical manipulative did. Specifically, in responding to data analysis questions, students who used the virtual manipulative before the physical manipulative were more likely to describe work as constant across different lengths of frictionless inclined planes (or pulley systems) and were more likely to adequately compare work and potential energy, whereas students who used the physical manipulative first were more likely to talk about work and potential energy separately. On the other hand, no strong support was found to indicate that the physical manipulative better supported students’ understanding of a specific concept. In addition, students’ responses to the survey questions indicate that students tend to value data from a computer simulation more than from a physical experiment. The interview analysis indicates that the virtual environment better supported the students to create new ideas than the physical environment did. These results suggest that the traditional wisdom that students learn best from physical experiments is not necessarily true. Thus, researchers should continue to investigate how to best interweave students’ experiences with physical and virtual manipulatives. In addition, it may be useful for curriculum designers and instructors to spend more of their efforts designing learning experiences that make use of virtual manipulatives.
Petersson, Malin, i Caroline Bäckström. "How does a Government Lower Primary School in India work with mathematics? - A study on how the teachers’ mathematical beliefs affect the norms operating in the classroom". Thesis, Malmö högskola, Lärarutbildningen (LUT), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-35819.
Pełny tekst źródłaFor our study, we visited a Government Lower Primary School in India to inquiry about how a school in another schooling context teaches mathematics. Our research questions were: How does an Indian Government Lower Primary School work with mathematics? What are the teachers' perceptions of the school’s teaching approach? In addition to these questions and to inquire deeper into this subject, we also investigated How do the teachers’ perceptions and method of teaching connect to Yackel and Cobb’s framework of the different kinds of norms operating in the classroom?We did a qualitative study, staying at the school for three weeks to interview teachers about their method of teaching mathematics as well as observing how they were teaching mathematics and the norms that operated in the classroom. We also gathered information about their mathematics laboratory. During our interviews and observations we came to the conclusion that the school worked with activity-based learning by using manipulative materials. All teachers as well as the principal cooperatively strived to meet the curricula objectives, with the same teaching approach. We also found that the teachers’ values and beliefs about how mathematics should be taught, affect the norms operating in the classroom.This study cannot be generalised for all schools in India or even in this area. This study is a minor study which only considered one particular school which used an interesting teaching method, activity-based learning with manipulatives.
Nilsson, Daniel. "Development of Next-Generation Optical Tweezers : The New Swiss Army Knife of Biophysical and Biomechanical Research". Thesis, Umeå universitet, Institutionen för fysik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172362.
Pełny tekst źródłaDubois, David. "Etude de la chimie de la haute et basse atmosphère de Titan : approche expérimentale". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLV049/document.
Pełny tekst źródłaTitan is the only moon in the SolarSystem to possess its own dense and gravitationallybound atmosphere, and is even larger than planetMercury. Its rocky diameter is a mere 117 km shy ofGanymede’s. If we were to scoop up a 1 cm3 sam-ple from Titan’s upper atmosphere, we would findtwo dominant molecules: molecular nitrogen N2 andmethane CH4. Should we look a bit more carefully,we would find many neutral molecules and positiveand negative ion compounds. These chemical speciesare the outcome of processes resulting from ener-getic radiation reaching Titan’s upper atmosphere,breaking apart the initial N2 and CH4. A cascadeof subsequent reactions will trigger the formationof new gas phase products more and more com-plex. Eventually, these products mainly contain-ing hydrogen, carbon and nitrogen will form largefractal aggregates composing the opaque haze en-shrouding the surface of Titan. This haze is whatgives Titan such a unique brownish hue. Most ofthe photochemically-produced volatiles will eventu-ally condense in the lower atmosphere, where theymay aggregate to form micrometer-sized icy parti-cles and clouds. During my PhD, I have focusedmy studies on (i) the gas phase reactivity of aerosolprecursors in experimental conditions analogous toTitan’s upper atmosphere (Chapters 3 & 4), and (ii)the end of life of some of the products as they con-dense in the lower and colder atmosphere (Chapter5). I used two experiments to address these respec-tive issues: the PAMPRE plasma reactor, located atLATMOS, UVSQ, Guyancourt, France, and the Ac-quabella chamber at the Jet Propulsion Laboratory,California Institute of Technology, Pasadena, USA.In this manuscript, I present my work on the neutraland positive ion reactivity in the PAMPRE plasmadischarge, as well as ice photochemistry results usinglaser irradiation in near-UV wavelengths
Pinto, Ana Catarina Pires. "Advanced Mobile Manipulation for Logistics in Hospitals or Laboratories". Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/84607.
Pełny tekst źródłaPinto, Ana Catarina Pires. "Advanced Mobile Manipulation for Logistics in Hospitals or Laboratories". Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/84607.
Pełny tekst źródła"Exclusionary manipulation of carbon permit markets: a laboratory test". MIT Joint Program on the Science and Policy of Global Change, 2002. http://hdl.handle.net/1721.1/3553.
Pełny tekst źródłaAbstract in HTML and technical report in PDF available on the Massachusetts Institute of Technology Joint Program on the Science and Policy of Global Change Website. (http://mit.edu/globalchange/www/)
Includes bibliographical references (p. 18-19).
Gomes, Erica da Cunha. "Miniature Robotic Manipulator for Remote Chemistry Laboratory". Master's thesis, 2018. https://repositorio-aberto.up.pt/handle/10216/114141.
Pełny tekst źródłaGomes, Erica da Cunha. "Miniature Robotic Manipulator for Remote Chemistry Laboratory". Dissertação, 2018. https://repositorio-aberto.up.pt/handle/10216/114141.
Pełny tekst źródłaBoyle, Alan Edmund Lawrence. "Differential effects of an early housing manipulation on cocaine-induced activity and self-administration in laboratory rats". Thesis, 1990. http://spectrum.library.concordia.ca/3019/1/MM59131.pdf.
Pełny tekst źródłaUddin, Md Momin Kamal. "Laboratory studies of in-situ redox manipulation for remediation of PCE, TCE and Cr(VI) contaminated groundwater in Atlantic Coastal Plain sediments". 2002. http://purl.galileo.usg.edu/uga%5Fetd/uddin%5Fmdmomin%5Fk%5F200212%5Fphd.
Pełny tekst źródłaDirected by Valentine A. Nzengung. Includes articles submitted to Journal of environmental quality, and Environmental toxicological chemistry. Includes bibliographical references.
Elliott, David B., Richard J. Foster, David J. Whitaker, Andy J. Scally i John G. Buckley. "Analysis of lower limb movement to determine the effect of manipulating the appearance of stairs to improve safety: a linked series of laboratory-based, repeated measures studies". 2015. http://hdl.handle.net/10454/8225.
Pełny tekst źródłaBackground: Falls on stairs are a common and dangerous problem for older people. This series of studies evaluated whether or not selected changes to the appearance of stairs could make them safer for older people to negotiate. Objectives: To determine the effect of (1) a step edge highlighter and its position and (2) an optimised horizontal–vertical (H–V) visual illusion placed on a step riser on gait safety during stair descent and ascent. Design: A series of studies using a repeated measures, laboratory-based design, investigating gait control and safety in independently mobile older people. Setting: The University of Bradford Vision and Mobility Laboratory. Participants: Fit and healthy older people aged 60 years of age or more, independently mobile, reasonably active and with normal healthy eyes and corrected vision. Interventions: A step edge highlighter in a variety of offsets from the stair edge and an optimised H–V visual illusion placed on the stair riser. The H–V illusion was provided on a staircase by horizontal step edge highlighters on the tread edges and vertical stripes on the step risers. Main outcome measures: Gait parameters that are important for safe stepping in ascent and descent, particularly toe clearance during stair ascent and heel clearance during stair descent. Results: The step edge highlighter increased the precision of heel clearance during stepping and its positioning relative to the tread edge determined the extent of heel clearance over the tread edge. Positioning the highlighter away from the tread edge, as is not uncommonly provided by friction strips, decreased heel clearance significantly and led to greater heel scuffs. Although psychophysics experiments suggested that higher spatial frequencies of the H–V illusion might provide greater toe clearance on stair ascent, gait trials showed similar increased toe clearances for all spatial frequencies. When a 12 cycle per step spatial frequency H–V illusion was used, toe clearance increases of approximately 1 cm (17.5%) occurred without any accompanying changes in other important gait parameters or stability measures. Conclusions: High-contrast tread edge highlighters present on steps and stairs and positioned flush with the edge of the tread or as near to this as possible should improve stair descent safety in older people. A H–V illusion positioned on the riser of a raised surface/walkway (e.g. kerbs) and/or the top and/or bottom of a stairway is likely to increase foot clearance over the associated step/stair edge, and appears not to lead to any decrement in postural stability. Thus, their use is likely to reduce trip risk and hence improve stair ascent safety. The effect of the step and stair modifications should be assessed in older people with visual impairment. The only other remaining assessment that could be made would be to assess fall prevalence on steps and stairs, perhaps in public buildings, with and without these modifications.
National Institute for Health Research, Public Health Research programme. PHR programme as project number 10/3009/06
Halcomb, Meredith Ellen. "Lithium effects on ethanol intake in impulsive mice". Thesis, 2013. http://hdl.handle.net/1805/3740.
Pełny tekst źródłaThe present study sought to identify the effects of chronic lithium administration on ethanol intakes in high alcohol-preferring (HAP) mice. Lithium is a well-established treatment for bipolar disorder and has demonstrated efficacy in reducing impulsivity, an endophenotype of the disease. Impulsivity is also a prominent trait of alcoholism. HAP mice display a preference for consuming substantial amounts of ethanol and exhibit abnormally high levels of impulsivity. Previous work has determined that chronic lithium exposure in HAP mice reduces their levels of impulsivity. The present study analyzed fluctuations in established intake patterns after lithium exposure and how pre-exposure to lithium would affect ethanol intake acquisition. The results showed an increase in ethanol intake and no change in preference for ethanol over water in lithium treated mice. There was an increase in overall total fluid consumption in these mice, likely resulting from polydipsic effects. There also appeared to be a potentiated lithium toxicity effect found in those mice pre-exposed to lithium. The conclusion was that lithium therapy does not decrease ethanol consumption in HAP mice.